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The use of lens anterior capsule disc for corneal endothelium protection during femtosecond laser-assisted cataract surgery in eyes with low endothelial cell density 在飞秒激光辅助白内障手术中使用晶状体前囊盘保护低内皮细胞密度眼的角膜内皮
Pub Date : 2024-02-28 DOI: 10.1016/j.aopr.2024.02.002
Nina Asrini Noor, Johan Hutauruk, Tjahjono D. Gondhowiardjo
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引用次数: 0
Efficacy of 3% diquafosol combined with azelastine hydrochloride in allergic conjunctivitis patients with dry eye 3% 地卡夫索联合盐酸阿司匹林对过敏性结膜炎干眼症患者的疗效
Pub Date : 2024-02-10 DOI: 10.1016/j.aopr.2024.01.006
Lin Lin , Yirui Zhu , Kelan Yuan, Yujie Mou, Hanhe Zhao, Yayin Wu, Xiuming Jin
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引用次数: 0
Evaluating for unrecognized deficits in perimetry associated with functional upper eyelid malposition 评估与功能性上眼睑位置不正有关的未识别的视力缺陷
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.007
Linyan Wang , Davin C. Ashraf , Michael Deiner , Oluwatobi O. Idowu , Seanna R. Grob , Bryan J. Winn , M Reza Vagefi , Robert C. Kersten

Objective

To investigate whether functional upper eyelid malposition is associated with unrecognized deficits in automated perimetry among glaucoma patients by examining patients undergoing eyelid surgery who had not been identified as requiring eyelid taping during glaucoma field testing.

Methods

In this retrospective pre-post study, an automated database search followed by manual chart review was used to identify eligible patients from January 2012 to March 2020. Included patients had reliable visual field testing within two years before and after functional upper blepharoplasty or ptosis repair and no comorbid ocular diagnoses. As part of routine practice, glaucoma visual field technicians taped patients with pupil-obstructing eyelid malposition; taped examinations were excluded from analysis. Clinical and demographic characteristics, mean deviation, and pattern standard deviation were evaluated within a two year period before and after eyelid surgery.

Results

The final analysis included 60 eyes of 38 patients. Change in visual field parameters after eyelid surgery did not reach statistical significance in crude or adjusted analyses. Among patients with ptosis, the margin reflex distance-1 was not associated with change in mean deviation after surgery (Pearson R2 ​= ​0.0061; P ​= ​0.700). Five of 17 eyes excluded from analysis due to unreliable pre-operative visual fields demonstrated substantial improvement after surgery.

Conclusions

Functional upper eyelid malposition does not appear to cause spurious visual field abnormalities among glaucoma patients with reliable visual fields who were determined not to require eyelid taping at the time of their visual fields. Unreliable visual fields could be a sign of eyelid interference in this population.

目的通过对接受眼睑手术但在青光眼视野测试中未被确认为需要眼睑粘贴的患者进行检查,研究功能性上眼睑位置不正是否与青光眼患者未被发现的自动周边测量缺陷有关。方法在这项事后回顾性研究中,通过自动数据库搜索和人工病历审查来确定 2012 年 1 月至 2020 年 3 月期间符合条件的患者。所纳入的患者在功能性上睑成形术或上睑下垂修复术前后两年内均接受过可靠的视野测试,且无合并眼部诊断。作为常规做法的一部分,青光眼视野技术人员会对瞳孔阻塞性眼睑错位患者进行录音;录音检查不纳入分析。对眼睑手术前后两年内的临床和人口统计学特征、平均偏差和模式标准偏差进行了评估。在粗略分析和调整分析中,双眼皮手术后视野参数的变化均未达到统计学意义。在上睑下垂患者中,边缘反射距离-1与术后平均偏差的变化无关(Pearson R2 = 0.0061;P = 0.700)。在因术前视野不可靠而被排除在分析之外的 17 只眼睛中,有 5 只在术后得到了实质性的改善。结论在视野可靠且在视野检查时被确定不需要眼睑粘贴的青光眼患者中,功能性上眼睑位置不正似乎不会导致假性视野异常。不可靠的视野可能是眼睑干扰这一人群的信号。
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引用次数: 0
Efficacy of 3% diquafosol combined with azelastine hydrochloride in allergic conjunctivitis patients with dry eye 3% 地卡夫索联合盐酸阿司匹林对过敏性结膜炎干眼症患者的疗效
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.006
Lin Lin, Yirui Zhu, Kelan Yuan, Yujie Mou, Hanhe Zhao, Yaying Wu, Xiuming Jin
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引用次数: 0
A two-year longitudinal observational study of the peripapillary microvasculature in pediatric type 1 diabetes mellitus patients without visual impairment or diabetic retinopathy 对无视力障碍或糖尿病视网膜病变的儿童 1 型糖尿病患者毛细血管周围进行为期两年的纵向观察研究
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.001
Lipu Cui, Chenhao Yang, Haidong Zou
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引用次数: 0
TOC 技术选择委员会
Pub Date : 2024-02-01 DOI: 10.1016/S2667-3762(24)00015-5
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引用次数: 0
Response to letter to the editor regarding "Is relying on RNFL specific enough to identify any changes in the CNS?" 回复致编辑的信,内容涉及 "依靠 RNFL 的特异性是否足以识别中枢神经系统的任何变化?
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.003
Hanfei Wu , Haishuang Lin , Mengting Ruan, Huanjie Fang, Nannan Dong, Tiewei Wang, Feifei Yu, Jiawei Zhao
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引用次数: 0
Recent progress of nanomedicine in managing dry eye disease 纳米医学在治疗干眼症方面的最新进展
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.008
Zeen Lv , Su Li , Guixiang Zeng , Ke Yao , Haijie Han

Background

Dry eye disease (DED) is a commonly reported ocular complaint that has garnered significant attention in recent research. The global occurrence of DED ranges from 5% to 50%, impacting a substantial proportion of individuals worldwide with increasing frequency. Although topical administration remains the mainstream drug delivery method for ocular diseases, it suffers from drawbacks such as low bioavailability, rapid drug metabolism, and frequent administration requirements. Fortunately, the advancements in nanomedicine offer effective solutions to address the aforementioned issues and provide significant assistance in the treatment of DED.

Main text

DED is considered a multifactorial disease of the ocular surface and tear film, in which the integrity of tear film function and structure plays a crucial role in maintaining the homeostasis of the ocular surface. The conventional treatment for DED involves the utilization of artificial tear products, cyclosporin, corticosteroids, mucin secretagogues, and nonsteroidal anti-inflammatory drugs. Furthermore, nanomedicine is presently a significant field of study, with numerous clinical trials underway for various nanotherapeutics including nanoemulsions, nanosuspensions, liposomes, and micelles. Notably, some of these innovative nanoformulations have already received FDA approval as novel remedies for DED, and the advancement of nanomedicine is poised to offer enhanced prospects to solve the shortcomings of existing treatments for DED partially.

Conclusions

This article provides an overview of the latest advancements in nanomedicine for DED treatment, while the field of DED treatment is expected to witness a remarkable breakthrough shortly with the development of nanomedicine, bringing promising prospects for patients worldwide suffering conditions.

背景干眼症(DED)是一种常见的眼部疾病,在最近的研究中备受关注。DED 的全球发病率从 5%到 50%不等,影响着全球很大一部分人,而且发病频率越来越高。虽然局部用药仍是眼部疾病的主流给药方法,但它存在生物利用度低、药物代谢快和给药要求频繁等缺点。正文DED被认为是眼表和泪膜的一种多因素疾病,其中泪膜功能和结构的完整性在维持眼表平衡方面起着至关重要的作用。DED 的传统治疗方法包括使用人工泪液产品、环孢素、皮质类固醇、粘蛋白促泌剂和非甾体抗炎药。此外,纳米医学目前也是一个重要的研究领域,各种纳米治疗药物(包括纳米乳剂、纳米悬浮剂、脂质体和胶束)的大量临床试验正在进行中。值得注意的是,其中一些创新型纳米制剂已获得美国食品及药物管理局(FDA)批准,可作为治疗 DED 的新型疗法,纳米医学的发展有望为部分解决现有 DED 治疗方法的不足之处提供更广阔的前景。结论 本文概述了纳米医学在 DED 治疗方面的最新进展,随着纳米医学的发展,DED 治疗领域有望在短期内取得重大突破,为全球 DED 患者带来光明前景。
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引用次数: 0
Reply to the letter to the editor regarding “Is relying on RNFL specific enough to identify any changes in the CNS?” 回复致编辑的信,内容涉及 "依靠 RNFL 的特异性是否足以识别中枢神经系统的任何变化?
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.003
Hanfei Wu, Haishuang Lin, Mengting Ruan, Huanjie Fang, Nannan Dong, Tiewei Wang, Feifei Yu, Jiawei Zhao
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引用次数: 0
Evaluating for unrecognized deficits in perimetry associated with functional upper eyelid malposition 评估与功能性上眼睑位置不正有关的未识别的视力缺陷
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.007
Linyan Wang, Davin C. Ashraf, Michael Deiner, Oluwatobi O. Idowu, Seanna R. Grob, Bryan J. Winn, M. Vagefi, Robert C. Kersten
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引用次数: 0
期刊
Advances in ophthalmology practice and research
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