Advances in ophthalmology practice and research最新文献

{"title":"Association between glaucoma and stroke: A bidirectional mendelian randomization study","authors":"Kai Wang ,&nbsp;Xueqi Lin ,&nbsp;Siting Sheng ,&nbsp;Dan Chen ,&nbsp;Xin Liu ,&nbsp;Ke Yao","doi":"10.1016/j.aopr.2024.04.003","DOIUrl":"10.1016/j.aopr.2024.04.003","url":null,"abstract":"<div><h3>Purpose</h3><p>Observational studies have reported positive associations between glaucoma and stroke; however, controversial results exist. Importantly, the nature of the relationship remains unknown since previous studies were not designed to test causality. Therefore, we aimed to investigate the possible causal relationships between glaucoma and stroke.</p></div><div><h3>Methods</h3><p>Our two-sample Mendelian randomization (MR) encompassed multi-ethnic large-scale genome-wide association studies with more than 20000 cases and 260000 controls for glaucoma, and more than 80000 cases and 630000 controls for stroke. Individual effect estimates for each SNP were combined using the inverse-variance weighted (IVW) method. To avoid potential pleiotropic effects, we adjusted the main results by excluding genetic variants associated with metabolic factors. The weighted median and MR-Egger methods were also used for the sensitivity analysis.</p></div><div><h3>Results</h3><p>Our MR analysis revealed that glaucoma and its subtypes, including primary open-angle glaucoma and primary angle-closure glaucoma, exhibited no causal role in relation to any stroke (AS), any ischemic stroke (AIS), large-artery atherosclerotic stroke (LAS), small-vessel stroke (SVS), or cardioembolic stroke (CES) across MR analyses (all <em>P</em> ​&gt; ​0.05). The null associations remained robust even after adjusting for metabolic-related traits and were consistent in both the European and Asian populations. Furthermore, reverse MR analyses also did not indicate any significant causal effects of AS, AIS, LAS, or CES on glaucoma risk.</p></div><div><h3>Conclusions</h3><p>Evidence from our series of causal inference approaches using large-scale population-based MR analyses did not support causal effects between glaucoma and stroke. These findings suggest that the relationship of glaucoma management and stroke risk prevention should be carefully evaluated in future studies. In turn, stroke diagnosis should not be simply applied to glaucoma risk prediction.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 3","pages":"Pages 147-155"},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266737622400026X/pdfft?md5=f5822fa1d44ff49b6f4b0d75f5a86be2&pid=1-s2.0-S266737622400026X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140769104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized treatment approaches in intraocular cancer","authors":"Yating Liu ,&nbsp;Alexander C. Rokohl ,&nbsp;Yongwei Guo ,&nbsp;Ke Yao ,&nbsp;Wanlin Fan ,&nbsp;Ludwig M. Heindl","doi":"10.1016/j.aopr.2024.03.005","DOIUrl":"10.1016/j.aopr.2024.03.005","url":null,"abstract":"<div><h3>Background</h3><p>Intraocular malignant tumors represent a severe disease that threatens vision as well as life. To better extend the life of the patient, preserve visual function, and maintain ocular aesthetics, selecting the appropriate timing and methods of treatment becomes crucial.</p></div><div><h3>Main text</h3><p>With the continuous advancement of medical technology, the techniques and methods for treating intraocular malignant tumors are constantly evolving. While surgery was once considered the optimal method to prolong patient survival and prevent local recurrence, the discovery and application of various treatments such as radiotherapy, laser therapy, chemotherapy, cryotherapy, and monoclonal antibodies have led to a greater diversity of treatment options. This diversity offers more possibilities to develop personalized treatment plans, and thereby maximize patient benefit. This article reviews the various treatment methods for intraocular malignant tumors, including indications for treatment, outcomes, and potential complications.</p></div><div><h3>Conclusions</h3><p>Differentiating small intraocular malignant tumors from pigmented lesions is challenging, and ongoing monitoring with regular follow-up is required. Small to medium-sized tumors can be treated with radiotherapy combined with transpupillary thermotherapy. Depending on the tumor's distance from the optic disc, surgery with partial resection may be considered for distant tumors, while proximal tumors may require complete enucleation. Systemic chemotherapy has been widely applied to patients with retinal tumors, lymphomas, and intraocular metastatic cancers, but has limited efficacy in patients with choroidal melanoma. Antagonists of Vascular Endothelial Growth Factor (Anti-VEGF) drugs can improve patient vision and quality of life, while the efficacy of immunotherapy and molecular targeted therapy is still under research.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 3","pages":"Pages 112-119"},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000234/pdfft?md5=cd20b9dbf34570c7951965f15ad080e8&pid=1-s2.0-S2667376224000234-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140790633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global incidence and prevalence of malignant orbital tumors","authors":"Weina Zhang ,&nbsp;Alexander C. Rokohl ,&nbsp;Yongwei Guo ,&nbsp;Ke Yao ,&nbsp;Wanlin Fan ,&nbsp;Ludwig M. Heindl","doi":"10.1016/j.aopr.2024.04.002","DOIUrl":"10.1016/j.aopr.2024.04.002","url":null,"abstract":"<div><h3>Purpose</h3><p>Aims to provide an overview of the contemporary epidemiology of malignant orbital tumors by analyzing population-based incidence patterns across various regions worldwide.</p></div><div><h3>Methods</h3><p>In this article, we retrieved orbital malignancy data from the MEDLINE database and analyzed the incidence and prevalence of orbital malignancies worldwide. We performed the literature search by searching on the Mesh terms for malignant orbital tumors (\"orbital\", \"tumor\", \"lymphoma\", \"malignant\", \"cancer\", \"incidence\", and \"epidemiology\"). All included studies were published between 1993 and 2023 and were written in English.</p></div><div><h3>Results</h3><p>Ocular or ophthalmic lymphoma most frequently occurred in the orbit, with a prevalence ranging from 47% to 54%. The incidence of malignant orbital tumors was increasing in the USA (2.0 per million (1981–1993), Netherlands (0.86 (1981–1985) to 2.49 (2001–2005) per million) and South Korea (0.3–0.8 per million (1999–2016)), respectively. Ophthalmic lymphoma which includes orbit lymphoma was increasing in Canada (0.17–1.47 per million (1992–2010)), Denmark (0.86 per million (1981–1985) to 2.49 per million (2001–2005)), respectively.</p></div><div><h3>Conclusions</h3><p>The predominant primary malignant orbital tumor in adults was lymphoma. Ocular or ophthalmic lymphoma most frequently occured in the orbit. The limited data available suggested an increasing trend in the incidence of malignant orbital tumors in each country included, which were mainly attributed to the increase in lymphoma. Generally, incidence rates were found to increase with advancing age, with no difference between males and females.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 3","pages":"Pages 128-133"},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000258/pdfft?md5=a9b2f717d8d47403acbe608cea43c19a&pid=1-s2.0-S2667376224000258-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140796202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A UV-related risk analysis in ophthalmic malignancies: Increased UV exposure may cause ocular malignancies","authors":"Xiaojun Ju ,&nbsp;Alexander C. Rokohl ,&nbsp;Xueting Li ,&nbsp;Yongwei Guo ,&nbsp;Ke Yao ,&nbsp;Wanlin Fan ,&nbsp;Ludwig M. Heindl","doi":"10.1016/j.aopr.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.aopr.2024.04.001","url":null,"abstract":"<div><h3>Purpose</h3><p>To explore the role of ultraviolet radiation (UVR) in the occurrence and development of various ocular malignancies.</p></div><div><h3>Methods</h3><p>In this article, we retrieved ocular malignancy data from the Global Cancer Observatory (GCO) and performed correlation analysis with the global UV index and sunshine duration. We searched for associated studies using the following databases: Embase, Pubmed, Cochrane Library, and Google Scholar. We conducted the literature by searching the Mesh terms denoting an exposure of interest (\"UV radiation\", \"ultraviolet rays\", and \"ocular malignancies\", All studies included are published until December 30, 2023 without language restrictions.</p></div><div><h3>Results</h3><p>The mechanisms and epidemiological statistics of UVR on the onset and progression of eyelid malignancies are the most studied and clear. The role of UVR in conjunctival melanoma is similar to that in eyelid melanoma. The relationship between uveal melanoma and UVR is controversial, however, it may have at least a certain impact on its prognosis. UVR causes ocular surface squamous neoplasia by further activating HPV infection.</p></div><div><h3>Conclusions</h3><p>UVR is a decisive risk factor for ocular malignancies, but the incidence of ultraviolet-induced tumors is also affected by many other factors. A correct and comprehensive understanding of the mechanisms of UVR in the pathogenesis of ocular malignant tumors can provide patients with more effective and selective immune regulation strategies.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 2","pages":"Pages 98-105"},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000246/pdfft?md5=39c7b132d984605dc2a43b0ddb236370&pid=1-s2.0-S2667376224000246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular surface heat flux density as a biomarker related to diabetic retinopathy (pilot study)","authors":"Lukyan Anatychuk,&nbsp;Roman Kobylianskyi,&nbsp;Oleg Zadorozhnyy,&nbsp;Taras Kustryn,&nbsp;Illia Nasinnyk,&nbsp;Andrii Korol,&nbsp;Nataliya Pasyechnikova","doi":"10.1016/j.aopr.2024.03.004","DOIUrl":"10.1016/j.aopr.2024.03.004","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 3","pages":"Pages 107-111"},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000222/pdfft?md5=7e188c5719d9efdc0f7049755f5dbaae&pid=1-s2.0-S2667376224000222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of smartphone technology and artificial intelligence for advanced ophthalmic care: A systematic review","authors":"Kai Jin ,&nbsp;Yingyu Li ,&nbsp;Hongkang Wu ,&nbsp;Yih Chung Tham ,&nbsp;Victor Koh ,&nbsp;Yitian Zhao ,&nbsp;Ryo Kawasaki ,&nbsp;Andrzej Grzybowski ,&nbsp;Juan Ye","doi":"10.1016/j.aopr.2024.03.003","DOIUrl":"10.1016/j.aopr.2024.03.003","url":null,"abstract":"<div><h3>Background</h3><p>The convergence of smartphone technology and artificial intelligence (AI) has revolutionized the landscape of ophthalmic care, offering unprecedented opportunities for diagnosis, monitoring, and management of ocular conditions. Nevertheless, there is a lack of systematic studies on discussing the integration of smartphone and AI in this field.</p></div><div><h3>Main text</h3><p>This review includes 52 studies, and explores the integration of smartphones and AI in ophthalmology, delineating its collective impact on screening methodologies, disease detection, telemedicine initiatives, and patient management. The collective findings from the curated studies indicate promising performance of the smartphone-based AI screening for various ocular diseases which encompass major retinal diseases, glaucoma, cataract, visual impairment in children and ocular surface diseases. Moreover, the utilization of smartphone-based imaging modalities, coupled with AI algorithms, is able to provide timely, efficient and cost-effective screening for ocular pathologies. This modality can also facilitate patient self-monitoring, remote patient monitoring and enhancing accessibility to eye care services, particularly in underserved regions. Challenges involving data privacy, algorithm validation, regulatory frameworks and issues of trust are still need to be addressed. Furthermore, evaluation on real-world implementation is imperative as well, and real-world prospective studies are currently lacking.</p></div><div><h3>Conclusions</h3><p>Smartphone ocular imaging merged with AI enables earlier, precise diagnoses, personalized treatments, and enhanced service accessibility in eye care. Collaboration is crucial to navigate ethical and data security challenges while responsibly leveraging these innovations, promising a potential revolution in care access and global eye health equity.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 3","pages":"Pages 120-127"},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000210/pdfft?md5=15dd74fd99010c9b70eb60504d51094d&pid=1-s2.0-S2667376224000210-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of sentiment and word frequency analysis of physician review sites to evaluate refractive surgery care","authors":"Victoria Vought ,&nbsp;Rita Vought ,&nbsp;Andrew S. Lee ,&nbsp;Irene Zhou ,&nbsp;Mansi Garneni ,&nbsp;Steven A. Greenstein","doi":"10.1016/j.aopr.2024.03.002","DOIUrl":"10.1016/j.aopr.2024.03.002","url":null,"abstract":"<div><h3>Background</h3><p>Online physician reviews increase transparency in health care, helping patients make informed decisions about their provider. Language processing techniques can quantify this data and allow providers to better understand patients' experiences, perspectives, and priorities. The objective of this study was to assess patient satisfaction and understand the aspects of care that are valued by patients seeking refractive care using sentiment and word frequency analysis.</p></div><div><h3>Methods</h3><p>Written reviews and Star ratings for members of the Refractive Surgery Alliance Society practicing in the United States were collected from Healthgrades, a popular physician rating website. Surgeons with at least one written review were included in the study. Reviews were scored from -1 (most negative) to +1 (most positive) using Valence Aware Dictionary sEntiment Reasoner (VADER). Reviews were stratified by demographic characteristics, namely gender, region, and years in practice. Word frequency analysis was applied to find the most common words and phrases.</p></div><div><h3>Results</h3><p>A total of 254 specialists and 3104 reviews were analyzed, with an average of 4.4/5 stars and mean 48 ratings each. Most physicians had positive reviews (96%, average VADER ​= ​0.69). Younger physicians (&lt;20 years since residency) had significantly higher Stars rating than senior peers (&gt;20 years) (<em>P</em> ​&lt; ​0.001). A similar trend was observed in VADER score (0.71 vs 0.69), although not statistically significant (<em>P</em> ​= ​0.06). No statistical differences were observed between Stars rating and VADER score by gender (<em>P</em> ​= ​0.66, <em>P</em> ​= ​0.83) or by geographical region (<em>P</em> ​= ​0.74, <em>P</em> ​= ​0.07). \"Staff\" (n ​= ​1269), \"professional\" (n ​= ​631), \"office\" (n ​= ​523), \"questions\" (n ​= ​424), and \"friendly\" (n ​= ​386) were frequently used in reviews, along with phrases such as \"the staff\" (n ​= ​273) and \"my questions\" (n ​= ​174). \"Surgery\" (n ​= ​719), \"staff\" (n ​= ​576), \"procedure\" (n ​= ​251), \"experience\" (n ​= ​243), and \"professional\" (n ​= ​240) were the most common words in positive reviews, while \"surgery\" (n ​= ​147), \"office\" (n ​= ​86), \"staff\" (n ​= ​54), \"time\" (n ​= ​47), and \"insurance\" (n ​= ​28) were the most commonly used in negative reviews.</p></div><div><h3>Conclusions</h3><p>Both the average Stars and VADER sentiment score suggest a high satisfaction among refractive patients. Word frequency analysis revealed that patients value non-clinical aspects of care, including interactions with staff, insurance coverage, and wait-times, suggesting that improving non-clinical factors could enhance patient satisfaction with refractive surgery.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 2","pages":"Pages 78-83"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000209/pdfft?md5=ea23a98b746597512a461225a39e3053&pid=1-s2.0-S2667376224000209-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140084149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life measurements in children and adolescents with refractive errors: A scoping review","authors":"Wei Wu ,&nbsp;Lisha Yi ,&nbsp;Kai Zhang ,&nbsp;Zipei Chen ,&nbsp;Caiping Shi ,&nbsp;Chen Chen ,&nbsp;Yilu Cai ,&nbsp;Lidan Hu ,&nbsp;Xiangjun Chen","doi":"10.1016/j.aopr.2024.03.001","DOIUrl":"10.1016/j.aopr.2024.03.001","url":null,"abstract":"<div><h3>Background</h3><p>Refractive errors, particularly myopia, are the leading visual disorders worldwide, significantly affecting the quality of life (QOL) even after correction. This scoping review focuses on health-related quality of life (HRQOL) measurements for children and adolescents with refractive errors.</p></div><div><h3>Main text</h3><p>We explored generic and disease-specific HRQOL tools, examining their content, psychometric properties, and the impact of various interventions on QOL. Two English databases—PubMed, Embase, and one Chinese database, CNKI, were searched for relevant studies published from January 2001 to October 2023. Inclusion criteria encompassed studies using standardized instruments to assess the QOL of children aged 0–18 with refractive errors. The review compares prevalent HRQOL measurements, analyzes children's refractive error assessments, and discusses intervention effects on patient QOL.</p></div><div><h3>Conclusions</h3><p>The study underlines the necessity of developing disease-specific QOL instruments for very young children and serves as a practical guide for researchers in this field. The findings advocate for a targeted approach in HRQOL assessment among the pediatric population, identifying critical gaps in current methodologies.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 2","pages":"Pages 84-94"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000192/pdfft?md5=1487260258181248186dbd591ed76281&pid=1-s2.0-S2667376224000192-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140269867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized treatment concepts in extraocular cancer","authors":"Sitong Ju ,&nbsp;Alexander C. Rokohl ,&nbsp;Yongwei Guo ,&nbsp;Ke Yao ,&nbsp;Wanlin Fan ,&nbsp;Ludwig M. Heindl","doi":"10.1016/j.aopr.2024.02.003","DOIUrl":"10.1016/j.aopr.2024.02.003","url":null,"abstract":"<div><h3>Background</h3><p>The periocular skin is neoplasms-prone to various benign and malignant. Periocular malignancies are more aggressive and challenging to cure and repair than those in other skin areas. In recent decades, immunotherapy has significantly advanced oncology, allowing the autoimmune system to target and destroy malignant cells. Skin malignancies, especially periocular tumors, are particularly sensitive to immunotherapy. This technique has dramatically impacted the successful treatment of challenging tumors.</p></div><div><h3>Main text</h3><p>Extraocular cancers, including eyelid (basal cell carcinoma, squamous cell carcinoma, melanoma, merkel cell carcinoma), conjunctival tumors (conjunctival melanoma, ocular surface squamous neoplasia) and other rare tumors, are unique and challenging clinical situations. Several genetic alterations associated with the pathogenesis of these diseases have been identified, and molecular mechanism are essential for the development of the immunotherapy agents, such as Hedgehog pathway inhibitors (vismodegib and sonidegib) for basal cell carcinoma, BRAF/MEK inhibitors (vemurafenib, dabrafenib, and encorafenib) for melanoma, and immune checkpoint inhibitors (Avelumab, pembrolizumab) for Merkel cell carcinoma.</p></div><div><h3>Conclusions</h3><p>The optimal treatment for periocular skin cancer depends on the type and size of the tumor and whether it involves orbital and adnexal structures. Adjuvant and neoadjuvant therapy with chemotherapy-targeted therapies and immune checkpoint inhibitors should be considered based on tumor type, tumor molecular profile, expected response rate, and candidacy for systemic treatment.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 2","pages":"Pages 69-77"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000118/pdfft?md5=edb4a670137034508a3c47340bef9273&pid=1-s2.0-S2667376224000118-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140082944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges","authors":"Yifei Niu ,&nbsp;Junfeng Ji ,&nbsp;Ke Yao ,&nbsp;Qiuli Fu","doi":"10.1016/j.aopr.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.aopr.2024.02.001","url":null,"abstract":"<div><h3>Background</h3><p>Degenerate eye disorders, such as glaucoma, cataracts and age-related macular degeneration (AMD), are prevalent causes of blindness and visual impairment worldwide. Other eye disorders, including limbal stem cell deficiency (LSCD), dry eye diseases (DED), and retinitis pigmentosa (RP), result in symptoms such as ocular discomfort and impaired visual function, significantly impacting quality of life. Traditional therapies are limited, primarily focus on delaying disease progression, while emerging stem cell therapy directly targets ocular tissues, aiming to restore ocular function by reconstructing ocular tissue.</p></div><div><h3>Main text</h3><p>The utilization of stem cells for the treatment of diverse degenerative ocular diseases is becoming increasingly significant, owing to the regenerative and malleable properties of stem cells and their functional cells. Currently, stem cell therapy for ophthalmopathy involves various cell types, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and retinal progenitor cells (RPCs). In the current article, we will review the current progress regarding the utilization of stem cells for the regeneration of ocular tissue covering key eye tissues from the cornea to the retina. These therapies aim to address the loss of functional cells, restore damaged ocular tissue and or in a paracrine-mediated manner. We also provide an overview of the ocular disorders that stem cell therapy is targeting, as well as the difficulties and opportunities in this field.</p></div><div><h3>Conclusions</h3><p>Stem cells can not only promote tissue regeneration but also release exosomes to mitigate inflammation and provide neuroprotection, making stem cell therapy emerge as a promising approach for treating a wide range of eye disorders through multiple mechanisms.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 2","pages":"Pages 52-64"},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266737622400009X/pdfft?md5=05a06b3fd055e75a8b44dbdd244049e6&pid=1-s2.0-S266737622400009X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}