Alcohol (Hanover, York County, Pa.)最新文献_第5页

The gut-brain axis in individuals with alcohol use disorder: An exploratory study of associations among clinical symptoms, brain morphometry, and the gut microbiome 酒精使用障碍患者的肠脑轴：临床症状、大脑形态测量和肠道微生物组之间关联的探索性研究

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-22 DOI: 10.1111/acer.15346

Katherine A. Maki, Gwenyth R. Wallen, Thomaz F. S. Bastiaanssen, Li-Yueh Hsu, Michael E. Valencia, Vijay A. Ramchandani, Melanie L. Schwandt, Nancy Diazgranados, John F. Cryan, Reza Momenan, Jennifer J. Barb

Background

Alcohol use disorder (AUD) is commonly associated with distressing psychological symptoms. Pathologic changes associated with AUD have been described in both the gut microbiome and brain, but the mechanisms underlying gut-brain signaling in individuals with AUD are unknown. This study examined associations among the gut microbiome, brain morphometry, and clinical symptoms in treatment-seeking individuals with AUD.

Methods

We performed a secondary analysis of data collected during inpatient treatment for AUD in subjects who provided gut microbiome samples and had structural brain magnetic resonance imaging (MRI; n = 16). Shotgun metagenomics sequencing was performed, and the morphometry of brain regions of interest was calculated. Clinical symptom severity was quantified using validated instruments. Gut-brain modules (GBMs) used to infer neuroactive signaling potential from the gut microbiome were generated in addition to microbiome features (e.g., alpha diversity and bacterial taxa abundance). Bivariate correlations were performed between MRI and clinical features, microbiome and clinical features, and MRI and microbiome features.

Results

Amygdala volume was significantly associated with alpha diversity and the abundance of several bacteria including taxa classified to Blautia, Ruminococcus, Bacteroides, and Phocaeicola. There were moderate associations between amygdala volume and GBMs, including butyrate synthesis I, glutamate synthesis I, and GABA synthesis I & II, but these relationships were not significant after false discovery rate (FDR) correction. Other bacterial taxa with shared associations to MRI features and clinical symptoms included Escherichia coli and Prevotella copri.

Conclusions

We identified gut microbiome features associated with MRI morphometry and AUD-associated symptom severity. Given the small sample size and bivariate associations performed, these results require confirmation in larger samples and controls to provide meaningful clinical inferences. Nevertheless, these results will inform targeted future research on the role of the gut microbiome in gut-brain communication and how signaling may be altered in patients with AUD.

酒精使用障碍（AUD）通常伴有令人痛苦的心理症状。与 AUD 相关的病理变化已在肠道微生物组和大脑中有所描述，但 AUD 患者的肠道-大脑信号转导机制尚不清楚。本研究考察了寻求治疗的 AUD 患者的肠道微生物组、大脑形态测量和临床症状之间的关联。

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引用次数: 0

Blockade of thromboxane A2 signaling attenuates ethanol-induced myocardial inflammatory response in mice 阻断血栓素 A2 信号传导可减轻乙醇诱发的小鼠心肌炎性反应

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-21 DOI: 10.1111/acer.15391

Weilun Ai, Carol A. Casey, Paras Kumar Mishra, Yazen Alnouti, Sohel Daria, Viswanathan Saraswathi

Background

Alcohol-associated cardiomyopathy (ACM) is a cardiac muscle disease characterized by inflammation and oxidative stress. Thromboxane-prostanoid receptor (TP-R) plays an important role in the pathogenesis of cardiovascular disease. Herein, we hypothesize that TP-R mediates alcohol-induced early cardiac injury.

Methods

Eight-week-old male C57BL/6 wild-type mice were fed a chronic ethanol (ET) or control diet (CON) for 10 days followed by a single binge of ethanol or maltose-dextrin through oral gavage. A cohort of ethanol-fed mice received SQ 29,548 (SQ), a TP-R antagonist. RNA sequencing, real-time PCR, and western blot analysis were performed on left ventricle to investigate alterations in genes and/or proteins mediating oxidative stress, inflammation, and cardiac remodeling. Sirius Red staining was performed to measure myocardial fibrosis.

Results

RNA-sequencing analysis of myocardium from CON and ET groups identified 142 genes that were significantly altered between the two groups. In particular, the gene expression of thioredoxin-interacting protein (TXNIP), a component of NLR family pyrin domain containing 3 (NLRP3) signaling, which mediates oxidative stress and inflammatory response, was upregulated in response to ethanol exposure. The myocardial protein levels of TP-R and thromboxane A2 synthase were increased upon alcohol exposure. Ethanol increased the levels of 4-hydroxynonenal, a marker of oxidative stress, with a concomitant increase in the protein levels of TXNIP and NLRP3, and administration of SQ attenuated these effects. Additionally, ethanol increased the protein levels of pro-inflammatory mediators, including tumor necrosis factor alpha and the NLRP3 downstream product, secretory interleukin 1 beta, and SQ blunted these effects. Finally, the Sirius red staining of the myocardium revealed an increase in collagen deposition in ethanol-fed mice which was attenuated by TP-R antagonism.

Conclusion

This study demonstrates that ethanol promotes the NLRP3 signaling pathway within the myocardium, leading to a pro-inflammatory milieu that potentially initiates early myocardial remodeling, and TP-R antagonism attenuates this effect.

酒精相关心肌病（ACM）是一种以炎症和氧化应激为特征的心肌疾病。血栓素-类固醇受体（TP-R）在心血管疾病的发病机制中发挥着重要作用。在此，我们假设 TP-R 介导了酒精诱发的早期心脏损伤。

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引用次数: 0

Rare and common variants associated with alcohol consumption identify a conserved molecular network 与饮酒有关的罕见和常见变异确定了一个保守的分子网络

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-21 DOI: 10.1111/acer.15399

Brittany S. Leger, John J. Meredith, Trey Ideker, Sandra Sanchez-Roige, Abraham A. Palmer

Background

Genome-wide association studies (GWAS) have identified hundreds of common variants associated with alcohol consumption. In contrast, genetic studies of alcohol consumption that use rare variants are still in their early stages. No prior studies of alcohol consumption have examined whether common and rare variants implicate the same genes and molecular networks, leaving open the possibility that the two approaches might identify distinct biology.

Methods

To address this knowledge gap, we used publicly available alcohol consumption GWAS summary statistics (GSCAN, N = 666,978) and whole exome sequencing data (Genebass, N = 393,099) to identify a set of common and rare variants for alcohol consumption. We used gene-based analysis to implicate genes from common and rare variant analyses, which we then propagated onto a shared molecular network using a network colocalization procedure.

Results

Gene-based analysis of each dataset implicated 294 (common variants) and 35 (rare variants) genes, including ethanol metabolizing genes ADH1B and ADH1C, which were identified by both analyses, and ANKRD12, GIGYF1, KIF21B, and STK31, which were identified in only the rare variant analysis, but have been associated with other neuropsychiatric traits. Network colocalization revealed significant network overlap between the genes identified via common and rare variants. The shared network identified gene families that function in alcohol metabolism, including ADH, ALDH, CYP, and UGT. Seventy-one of the genes in the shared network were previously implicated in neuropsychiatric or substance use disorders but not alcohol-related behaviors (e.g. EXOC2, EPM2A, and CACNG4). Differential gene expression analysis showed enrichment in the liver and several brain regions.

Conclusions

Genes implicated by network colocalization identify shared biology relevant to alcohol consumption, which also underlie neuropsychiatric traits and substance use disorders that are comorbid with alcohol use, providing a more holistic understanding of two disparate sources of genetic information.

全基因组关联研究（GWAS）已经发现了数百个与酒精消费有关的常见变体。相比之下，利用罕见变异进行的酒精消费基因研究仍处于早期阶段。此前没有任何关于酒精消费的研究探讨过常见变异和罕见变异是否涉及相同的基因和分子网络，因此这两种方法有可能发现不同的生物学特性。

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引用次数: 0

Prevalence of fetal alcohol spectrum disorder in foster care: A scoping review 寄养家庭中胎儿酒精谱系障碍的患病率：范围界定审查

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-20 DOI: 10.1111/acer.15394

Bailey Engesether, Mercedes Hoffner, Erika Johnson, Marilyn G. Klug, Svetlana Popova, Larry Burd

The prevalence of fetal alcohol spectrum disorder (FASD) has been reported to be disproportionately high among children in foster care compared with the general population. However, updated prevalence estimates of infants and children with FASD in foster care or the prevalence of placement of children with FASD in foster care make this unclear. This study examines two questions. Firstly, what is the prevalence of FASD among infants and children in foster care? Secondly, what is the likelihood of placement in foster care for infants and children with FASD? This review was designed using PRISMA-SCR and JBI scoping review guidelines. Three databases were searched for the period June 2012 to June 2023: PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Google Scholar for all countries. Overall prevalence estimates were calculated using a complementary log–log link model along with 95% confidence intervals. Firstly, the estimated prevalence of FASD among infants and children in foster care was 18.8%. Secondly, among children diagnosed with FASD 30.5% are placed into foster care, reflecting greatly increased risk of placement of infants and children with FASD in foster care. We conclude that routine screening for FASD is needed to improve the identification of infants and children with FASD. Increased attention is also needed on developing strategies for FASD prevention. Recognition that nearly one of every three children with FASD will enter foster care demonstrates the need for increased funding, enhanced training and greater availability of services for families and children impacted by FASD.

据报道，与普通人群相比，寄养儿童中胎儿酒精谱系障碍（FASD）的患病率高得不成比例。然而，关于寄养机构中患有 FASD 的婴儿和儿童的最新患病率估计或将患有 FASD 的儿童安置在寄养机构中的患病率还不清楚。本研究探讨了两个问题。首先，FASD 在寄养婴幼儿中的流行率是多少？其次，患有 FASD 的婴幼儿被寄养的可能性有多大？本综述的设计采用了 PRISMA-SCR 和 JBI 范围综述指南。检索了 2012 年 6 月至 2023 年 6 月期间的三个数据库：PubMed、Cumulative Index to Nursing and Allied Health Literature (CINAHL) 和 Google Scholar。采用互补对数-对数联系模型计算总体患病率估计值以及 95% 的置信区间。首先，寄养婴幼儿的 FASD 患病率估计为 18.8%。其次，在被诊断出患有 FASD 的儿童中，有 30.5% 被送往寄养机构，这反映出患有 FASD 的婴幼儿被送往寄养机构的风险大大增加。我们的结论是，需要对 FASD 进行常规筛查，以更好地识别患有 FASD 的婴幼儿。此外，还需要加强对制定 FASD 预防策略的关注。我们认识到，每三个患有 FASD 的儿童中就有一个会进入寄养家庭，这表明我们需要增加资金投入，加强培训，为受 FASD 影响的家庭和儿童提供更多的服务。

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引用次数: 0

Effects of early social isolation and adolescent single prolonged stress on anxiety-like behaviors and voluntary ethanol consumption in female Long Evans rats 早期社会隔离和青春期单次长期应激对雌性长伊文大鼠焦虑样行为和自愿乙醇消耗的影响

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-20 DOI: 10.1111/acer.15397

Stacy R. Pitcairn, Olivia A. Ortelli, Jeffrey L. Weiner

Background

Exposure to stress during childhood and adolescence is a risk factor for alcohol use disorder (AUD) and comorbid conditions, including posttraumatic stress disorder (PTSD). We previously established an adolescent social isolation (SI) model that leads to the emergence of a wide range of behavioral risk factors for AUD, including increased anxiety-like behavior, locomotor activity, and ethanol consumption in male and female rats. Here, we sought to test the hypothesis that SI may increase vulnerability to single prolonged stress (SPS), a rodent model of PTSD.

Methods

Female Long Evans rats (n = 8/group) were either single-housed or group-housed (GH) (4/cage) on postnatal day 21. One week later, rats underwent testing in the open field test (OFT), elevated plus-maze (EPM), and successive alleys test (SAT). Following initial behavioral testing, a subset of SI/GH rats were exposed to SPS. All rats were then tested on the novelty-suppressed feeding test (NSFT) followed by fear conditioning and home cage two-bottle choice to assess ethanol consumption.

Results

SI significantly increased activity in the OFT and anxiety-like behavior on the SAT, but not the EPM. While SI and SPS alone had no effect on the NSFT, exposure to both stressors significantly increased approach latency. Complex effects of stress history were observed across a 3-day fear conditioning paradigm and no group differences were observed with home cage ethanol consumption, regardless of prior ethanol exposure.

Conclusions

The results from this study provide novel evidence that SI interacts with SPS in female rats to influence behavior in assays of unconditioned anxiety-like behavior (NSFT) and conditioned fear. Surprisingly, stress exposure had no effect on home cage ethanol consumption. Ultimately, these models provide useful avenues to examine the interaction between stressful experiences, alcohol exposure, biological sex, and the neurobiological adaptations underlying potential risk factors for psychiatric conditions.

童年和青少年时期的压力暴露是酒精使用障碍（AUD）和包括创伤后应激障碍（PTSD）在内的合并症的风险因素。我们之前建立了一个青少年社会隔离（SI）模型，该模型会导致出现一系列罹患酒精中毒性精神障碍（AUD）的行为风险因素，包括雄性和雌性大鼠焦虑样行为、运动活动和乙醇消耗的增加。在这里，我们试图验证一个假设，即 SI 可能会增加对单次长期应激（SPS）的脆弱性，这是一种创伤后应激障碍的啮齿动物模型。

{"title":"Effects of early social isolation and adolescent single prolonged stress on anxiety-like behaviors and voluntary ethanol consumption in female Long Evans rats","authors":"Stacy R. Pitcairn, Olivia A. Ortelli, Jeffrey L. Weiner","doi":"10.1111/acer.15397","DOIUrl":"10.1111/acer.15397","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Exposure to stress during childhood and adolescence is a risk factor for alcohol use disorder (AUD) and comorbid conditions, including posttraumatic stress disorder (PTSD). We previously established an adolescent social isolation (SI) model that leads to the emergence of a wide range of behavioral risk factors for AUD, including increased anxiety-like behavior, locomotor activity, and ethanol consumption in male and female rats. Here, we sought to test the hypothesis that SI may increase vulnerability to single prolonged stress (SPS), a rodent model of PTSD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Female Long Evans rats (<i>n</i> = 8/group) were either single-housed or group-housed (GH) (4/cage) on postnatal day 21. One week later, rats underwent testing in the open field test (OFT), elevated plus-maze (EPM), and successive alleys test (SAT). Following initial behavioral testing, a subset of SI/GH rats were exposed to SPS. All rats were then tested on the novelty-suppressed feeding test (NSFT) followed by fear conditioning and home cage two-bottle choice to assess ethanol consumption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SI significantly increased activity in the OFT and anxiety-like behavior on the SAT, but not the EPM. While SI and SPS alone had no effect on the NSFT, exposure to both stressors significantly increased approach latency. Complex effects of stress history were observed across a 3-day fear conditioning paradigm and no group differences were observed with home cage ethanol consumption, regardless of prior ethanol exposure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results from this study provide novel evidence that SI interacts with SPS in female rats to influence behavior in assays of unconditioned anxiety-like behavior (NSFT) and conditioned fear. Surprisingly, stress exposure had no effect on home cage ethanol consumption. Ultimately, these models provide useful avenues to examine the interaction between stressful experiences, alcohol exposure, biological sex, and the neurobiological adaptations underlying potential risk factors for psychiatric conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141501975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial and ethnic disparities in receipt of specialty treatment across risk profiles of adults with heavy alcohol use 不同风险特征的重度酗酒成年人在接受专业治疗方面的种族和民族差异。

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-19 DOI: 10.1111/acer.15401

Vanessa A. Palzes, Felicia W. Chi, Constance Weisner, Andrea H. Kline-Simon, Derek D. Satre, Stacy Sterling

Background

Variation in specialty treatment utilization for alcohol use disorder (AUD) by patient subgroups is poorly understood. This study examined whether and how patient risk profiles predict receipt of specialty treatment and whether there are disparities by race and ethnicity.

Methods

This cohort study included 206,956 adults with heavy alcohol use (that which exceeded National Institute on Alcohol Abuse and Alcoholism guidelines) between June 1, 2013 and December 31, 2014, using electronic health record data from Kaiser Permanente Northern California. Five risk profiles (characterized by daily or weekly heavy drinking and level of health risks) were identified in latent class analysis. Logistic regression models were fit to examine associations between risk profiles, race, ethnicity, and receipt of specialty treatment (including addiction medicine, psychiatry, or integrated behavioral health visits, and AUD pharmacotherapy), adjusting for other patient characteristics. Variation in the association between risk profiles and receipt of specialty treatment by race/ethnicity was also examined.

Results

Overall, 4.0% of patients received specialty treatment. Latino/Hispanic and Asian/Pacific Islander patients had lower odds of receiving specialty treatment than White patients (adjusted odds ratio [aOR] [95% CI] = 0.80 [0.75, 0.85], and 0.64 [0.59, 0.70], respectively). The substance use disorder and mental health disorder (SUD/MH) risk profile had the highest odds of receiving specialty treatment (10.46 [9.65, 11.34]). Associations between risk profiles and receipt of specialty treatment significantly differed by race/ethnicity. Black patients in the SUD/MH risk profile, and Hispanic/Latino patients in the risk profile with heavy daily drinking and more health risks, had lower odds of receiving specialty treatment than their White counterparts (adjusted ratio of odds ratios [aROR] [95% CI] = 0.69 [0.50, 0.94], and 0.79 [0.67, 0.92], respectively).

Conclusions

This study provides new insights into racial/ethnic disparities in specialty treatment utilization for alcohol problems. Findings may help inform strategies for tailoring interventions to address heavy alcohol use.

背景：人们对患者亚群在酒精使用障碍（AUD）专科治疗利用率方面的差异知之甚少。本研究探讨了患者的风险特征是否以及如何预测接受专科治疗的情况，以及是否存在种族和民族差异：这项队列研究纳入了 2013 年 6 月 1 日至 2014 年 12 月 31 日期间大量饮酒（超过美国国家酒精滥用和酒精中毒研究所指南的饮酒量）的 206956 名成人，研究使用的是北加州凯泽医疗机构的电子健康记录数据。通过潜类分析确定了五种风险特征（以每日或每周大量饮酒和健康风险水平为特征）。在对其他患者特征进行调整后，拟合了逻辑回归模型，以检验风险特征、种族、民族和接受专科治疗（包括成瘾医学、精神病学或综合行为健康就诊以及 AUD 药物治疗）之间的关联。此外，还研究了不同种族/族裔的风险特征与接受专科治疗之间的关联差异：结果：总体而言，4.0% 的患者接受了专科治疗。拉丁裔/西班牙裔和亚太裔患者接受专科治疗的几率低于白人患者（调整后的几率比 [aOR] [95% CI] 分别为 0.80 [0.75, 0.85] 和 0.64 [0.59, 0.70]）。药物使用障碍和精神健康障碍（SUD/MH）风险特征接受专科治疗的几率最高（10.46 [9.65, 11.34]）。不同种族/族裔的风险特征与接受专科治疗之间的关系存在显著差异。属于 SUD/MH 风险特征的黑人患者，以及属于每日大量饮酒且健康风险较高风险特征的西班牙裔/拉丁美洲裔患者，接受专科治疗的几率低于白人患者（调整后的几率比 [aROR] [95% CI] = 0.69 [0.50, 0.94] 和 0.79 [0.67, 0.92]）：本研究为了解酗酒问题专科治疗利用率的种族/民族差异提供了新的视角。研究结果可能有助于为制定干预策略提供依据，以解决酗酒问题。

{"title":"Racial and ethnic disparities in receipt of specialty treatment across risk profiles of adults with heavy alcohol use","authors":"Vanessa A. Palzes, Felicia W. Chi, Constance Weisner, Andrea H. Kline-Simon, Derek D. Satre, Stacy Sterling","doi":"10.1111/acer.15401","DOIUrl":"10.1111/acer.15401","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Variation in specialty treatment utilization for alcohol use disorder (AUD) by patient subgroups is poorly understood. This study examined whether and how patient risk profiles predict receipt of specialty treatment and whether there are disparities by race and ethnicity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cohort study included 206,956 adults with heavy alcohol use (that which exceeded National Institute on Alcohol Abuse and Alcoholism guidelines) between June 1, 2013 and December 31, 2014, using electronic health record data from Kaiser Permanente Northern California. Five risk profiles (characterized by daily or weekly heavy drinking and level of health risks) were identified in latent class analysis. Logistic regression models were fit to examine associations between risk profiles, race, ethnicity, and receipt of specialty treatment (including addiction medicine, psychiatry, or integrated behavioral health visits, and AUD pharmacotherapy), adjusting for other patient characteristics. Variation in the association between risk profiles and receipt of specialty treatment by race/ethnicity was also examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 4.0% of patients received specialty treatment. Latino/Hispanic and Asian/Pacific Islander patients had lower odds of receiving specialty treatment than White patients (adjusted odds ratio [aOR] [95% CI] = 0.80 [0.75, 0.85], and 0.64 [0.59, 0.70], respectively). The substance use disorder and mental health disorder (SUD/MH) risk profile had the highest odds of receiving specialty treatment (10.46 [9.65, 11.34]). Associations between risk profiles and receipt of specialty treatment significantly differed by race/ethnicity. Black patients in the SUD/MH risk profile, and Hispanic/Latino patients in the risk profile with heavy daily drinking and more health risks, had lower odds of receiving specialty treatment than their White counterparts (adjusted ratio of odds ratios [aROR] [95% CI] = 0.69 [0.50, 0.94], and 0.79 [0.67, 0.92], respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides new insights into racial/ethnic disparities in specialty treatment utilization for alcohol problems. Findings may help inform strategies for tailoring interventions to address heavy alcohol use.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol sipping patterns, personality, and psychopathology in Children: Moderating effects of dorsal anterior cingulate cortex (dACC) activation 儿童饮酒模式、人格和心理病理学：背侧前扣带回皮层（dACC）激活的调节作用。

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-18 DOI: 10.1111/acer.15393

Ana Ferariu, Hansoo Chang, Alexei Taylor, Fengqing Zhang

Background

Alcohol, the most consumed drug in the United States, is associated with various psychological disorders and abnormal personality traits. Despite extensive research on adolescent alcohol consumption, the impact of early alcohol sipping patterns on changes in personality and mental health over time remains unclear. There is also limited information on the latent trajectory of early alcohol sipping, beginning as young as 9–10 years old. The dorsal anterior cingulate cortex (dACC) is crucial for cognitive control and response inhibition. However, the role of the dACC remains unclear in the relationship between early alcohol sipping and mental health outcomes and personality traits over time.

Methods

Utilizing the large data from the Adolescent Brain Cognitive Development study (N = 11,686, 52% males, 52% white, mean [SD] age 119 [7.5] months, 9807 unique families, 22 sites), we aim to comprehensively examine the longitudinal impact of early alcohol sipping patterns on psychopathological measures and personality traits in adolescents, filling crucial gaps in the literature.

Results

We identified three latent alcohol sipping groups, each demonstrating distinct personality traits and depression score trajectories. Bilateral dACC activation during the stop-signal task moderated the effect of early alcohol sipping on personality and depression over time. Additionally, bidirectional effects were observed between alcohol sipping and personality traits.

Conclusions

This study provides insights into the impact of early alcohol consumption on adolescent development. The key finding of our analysis is that poor response inhibition at baseline, along with increased alcohol sipping behaviors may accelerate the changes in personality traits and depression scores over time as individuals transition from childhood into adolescence.

背景：酒精是美国消费最多的药物，与各种心理障碍和异常人格特征有关。尽管对青少年饮酒进行了广泛的研究，但早期饮酒模式对人格和心理健康随时间推移而变化的影响仍不清楚。关于早期饮酒的潜在轨迹（从 9-10 岁开始）的信息也很有限。背侧前扣带回皮层（dACC）对认知控制和反应抑制至关重要。然而，随着时间的推移，早期饮酒与心理健康结果和人格特质之间的关系中，扣带回皮层的作用仍不明确：利用青少年大脑认知发展研究（N = 11,686, 52% 男性，52% 白人，平均 [SD] 年龄 119 [7.5] 个月，9807 个独特家庭，22 个研究地点）的大量数据，我们旨在全面研究早期饮酒模式对青少年心理病理测量和人格特质的纵向影响，填补文献中的重要空白：我们发现了三个潜在的饮酒群体，每个群体都表现出不同的人格特质和抑郁评分轨迹。在停止信号任务中的双侧dACC激活调节了早期饮酒对人格和抑郁的影响。此外，还观察到饮酒与人格特质之间的双向影响：本研究为早期饮酒对青少年成长的影响提供了见解。我们分析的主要发现是，随着个体从童年进入青春期，基线反应抑制能力差以及饮酒行为的增加可能会加速人格特质和抑郁评分的变化。

{"title":"Alcohol sipping patterns, personality, and psychopathology in Children: Moderating effects of dorsal anterior cingulate cortex (dACC) activation","authors":"Ana Ferariu, Hansoo Chang, Alexei Taylor, Fengqing Zhang","doi":"10.1111/acer.15393","DOIUrl":"10.1111/acer.15393","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol, the most consumed drug in the United States, is associated with various psychological disorders and abnormal personality traits. Despite extensive research on adolescent alcohol consumption, the impact of early alcohol sipping patterns on changes in personality and mental health over time remains unclear. There is also limited information on the latent trajectory of early alcohol sipping, beginning as young as 9–10 years old. The dorsal anterior cingulate cortex (dACC) is crucial for cognitive control and response inhibition. However, the role of the dACC remains unclear in the relationship between early alcohol sipping and mental health outcomes and personality traits over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Utilizing the large data from the Adolescent Brain Cognitive Development study (<i>N</i> = 11,686, 52% males, 52% white, mean [SD] age 119 [7.5] months, 9807 unique families, 22 sites), we aim to comprehensively examine the longitudinal impact of early alcohol sipping patterns on psychopathological measures and personality traits in adolescents, filling crucial gaps in the literature.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified three latent alcohol sipping groups, each demonstrating distinct personality traits and depression score trajectories. Bilateral dACC activation during the stop-signal task moderated the effect of early alcohol sipping on personality and depression over time. Additionally, bidirectional effects were observed between alcohol sipping and personality traits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides insights into the impact of early alcohol consumption on adolescent development. The key finding of our analysis is that poor response inhibition at baseline, along with increased alcohol sipping behaviors may accelerate the changes in personality traits and depression scores over time as individuals transition from childhood into adolescence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The need for persistent and expansive efforts to advance diversity in alcohol research 需要坚持不懈地开展广泛努力，促进酒精研究的多样性。

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-18 DOI: 10.1111/acer.15390

Amelia E. Talley

引用次数: 0

An incentive-based text-messaging intervention to reduce maternal alcohol use during pregnancy and lactation in South Africa (MaRISA study): Findings from a single-arm pilot study 在南非开展基于激励的短信干预，以减少孕期和哺乳期产妇饮酒（MaRISA 研究）：单臂试点研究结果。

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-17 DOI: 10.1111/acer.15392

Yukiko Washio, Lesley-Ann Erasmus-Claassen, Shantae N. Taylor, Zugui Zhang, Felicia A. Browne, Bronwyn Myers, Wendee M. Wechsberg, Charles D. H. Parry, Petal Petersen Williams

Background

South Africa has the highest rate of fetal alcohol spectrum disorders (FASD) globally. As with alcohol use during pregnancy, alcohol consumption while breastfeeding adversely impacts infant development. We pilot tested an incentive-based text-messaging intervention to reduce alcohol use during pregnancy and lactation in South Africa.

Methods

A single-arm pilot trial was conducted over 3 months in healthcare facilities in Cape Town, South Africa. Pregnant and breastfeeding participants tested positive for recent alcohol use by urinalysis. The three-month intervention had two components, contingency management of alcohol abstinence confirmed by urinalysis twice weekly and weekly health-related text messaging from an evidence-based brief intervention. We collected twice weekly urine samples for measurement of ethyl glucuronide (EtG), an alcohol biomarker, and measures of self-reported alcohol and drug use, violence exposure, and mental health at six weeks and three months post-enrollment.

Results

Sixty participants were enrolled, of whom 31 were pregnant and 29 lactating. The number of days with four or more drinks in the past month decreased from 9 days at baseline, on average, to 1–3 days (p-value range: 0.144–0.010) at follow-up timepoints. There were statistically significant increases in the proportions of participants with alcohol-negative urine tests (p < 0.001). The percentages of participants breastfeeding while using alcohol decreased from baseline to the end of 3 months in the overall sample and among those enrolled postpartum, though these were not significant (p-value range: 0.255–0.147). Maternal depression scores also decreased among participants enrolled postpartum (p = 0.054). Emotional abuse by the main partner, but neither physical nor sexual abuse, significantly decreased at both follow-ups in the overall sample (p = 0.032) and among participants enrolled while pregnant (p = 0.015).

Conclusions

This study is among the first to pilot test an incentive-based text-messaging intervention for maternal alcohol use and other outcomes such as depression and violence exposure. Further testing is warranted in a well-powered, randomized controlled trial.

背景介绍南非是全球胎儿酒精谱系障碍（FASD）发病率最高的国家。与孕期饮酒一样，哺乳期饮酒也会对婴儿发育产生不利影响。我们在南非试点测试了一种基于激励的短信干预措施，以减少孕期和哺乳期饮酒：方法：我们在南非开普敦的医疗机构进行了为期 3 个月的单臂试点试验。参加试验的孕妇和哺乳期妇女经尿检发现近期曾饮酒。为期三个月的干预包括两个部分：每周两次通过尿液分析确认戒酒的应急管理，以及每周一次通过循证简短干预发送与健康相关的短信。我们每周收集两次尿样，以测定酒精生物标志物乙基葡萄糖醛酸（EtG），并在入组后六周和三个月时对自我报告的酒精和药物使用情况、暴力暴露和心理健康进行测量：共有 60 名参与者参加，其中 31 人为孕妇，29 人为哺乳期妇女。过去一个月中饮酒四次或四次以上的天数从基线时的平均 9 天减少到随访时的 1-3 天（P 值范围：0.144-0.010）。尿检结果为酒精阴性的参与者比例有了统计学意义上的明显增加（P 结论）：本研究是首批针对孕产妇饮酒及其他结果（如抑郁和暴力暴露）的激励性短信干预进行试点测试的研究之一。有必要在一项有充分证据支持的随机对照试验中进行进一步测试。

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引用次数: 0

Articles of Public Interest 公益文章。

Alcohol (Hanover, York County, Pa.)

Pub Date : 2024-06-14 DOI: 10.1111/acer.15388

引用次数: 0