Nucleic acid-based inhalational drugs hold great clinical promise, but development has been limited by poor transfection efficiency among other factors. We previously described a plasmid (p)DNA powder without vector (naked pDNA powder) prepared for inhalation by spray-freeze-drying and containing hyaluronic acid (HA) as an excipient that demonstrated high transfection efficiency in the lungs. In the present study, we describe modified formulations in which HA is partially replaced by hydrophobic amino acids to enhance dispersibility in air and HA molecular weight is optimized for greater transfection efficiency. In vivo experiments in mice revealed that L-phenylalanine (Phe) in combination with HA conferred higher transfection efficiency than other hydrophobic amino acids. Furthermore, both in vivo and in vitro assays demonstrated that 50 kDa HA conferred higher transfection efficiency than other molecular weights and that the naked pDNA powder composed of 73% HA (50 kDa) and 25% Phe yielded the highest transfection efficiency among powders investigated. A higher relative Phe ratio enhanced aerosol performance but yielded lower transfection efficiency. This trade-off highlights the importance of comprehensively evaluating inhalational powders for both intrinsic transfection efficiency and aerosol performance.
{"title":"Development of naked pDNA inhalation powder formulation with high transfection efficiency using hyaluronic acid and phenylalanine as excipients","authors":"Takaaki Ito , Tomoyuki Okuda , Seiko Uede , Yuki Kushi , Kohei Tahara , Hirokazu Okamoto","doi":"10.1016/j.apt.2024.104750","DOIUrl":"10.1016/j.apt.2024.104750","url":null,"abstract":"<div><div>Nucleic acid-based inhalational drugs hold great clinical promise, but development has been limited by poor transfection efficiency among other factors. We previously described a plasmid (p)DNA powder without vector (naked pDNA powder) prepared for inhalation by spray-freeze-drying and containing hyaluronic acid (HA) as an excipient that demonstrated high transfection efficiency in the lungs. In the present study, we describe modified formulations in which HA is partially replaced by hydrophobic amino acids to enhance dispersibility in air and HA molecular weight is optimized for greater transfection efficiency. <em>In vivo</em> experiments in mice revealed that L-phenylalanine (Phe) in combination with HA conferred higher transfection efficiency than other hydrophobic amino acids. Furthermore, both <em>in vivo</em> and <em>in vitro</em> assays demonstrated that 50 kDa HA conferred higher transfection efficiency than other molecular weights and that the naked pDNA powder composed of 73% HA (50 kDa) and 25% Phe yielded the highest transfection efficiency among powders investigated. A higher relative Phe ratio enhanced aerosol performance but yielded lower transfection efficiency. This trade-off highlights the importance of comprehensively evaluating inhalational powders for both intrinsic transfection efficiency and aerosol performance.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 1","pages":"Article 104750"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-29DOI: 10.1016/j.apt.2024.104746
Yuxin Xie , Jiwei Lu , Ruibiao Hu , Nailing Wang , Zhijian Wang , Zhitao Yuan , Lixia Li
Serpentine is easily muddy and has a high zero electric point of zero charge (PZC), which leads to heterogeneous coagulation with pentlandite, which seriously affects the flotation of pentlandite. To solve this problem, from the new perspective of reducing the heterogeneous coagulation of pentlandite-serpentine and dispersing them, this study explored the influence of sodium tungstate as a dispersant on the dispersion of between pentlandite and serpentine using flotation tests, zeta potential tests, scanning electron microscope-energy dispersive spectrometer (SEM-EDS) examination, molecular dynamics simulation (MS), and calculations of the extended Derjaguin-Landau-Verwey-Overbeek (EDLVO) theory. The results show that −20 μm fine serpentine seriously deteriorates the flotation of pentlandite, while adding sodium tungstate can significantly promote the flotation separation of pentlandite and serpentine. MS simulation results showed that sodium tungstate could be chemisorbed with iron ions on the surface of pentlandite and mainly physisorbed with serpentine. EDLVO theoretical calculations show that after adsorption of sodium tungstate, the interaction between the two changed from attraction to repulsion at pH less than 10, and the mutual attraction was weakened at pH more significant than 10, thus weakening the heterogeneous coagulation between pentlandite and serpentine and causing serpentine to desorb from the surface of pentlandite, thus restoring the floatability of pentlandite, which SEM-EDS also confirmed. This provides a new insight into the dispersion mechanism of sodium tungstate as the innovative dispersant that is different from other dispersants for reducing heterogeneous coagulation of pentlandite and serpentine.
{"title":"Innovative dispersant for reducing heterogeneous coagulation of pentlandite and serpentine and new insight for their dispersion","authors":"Yuxin Xie , Jiwei Lu , Ruibiao Hu , Nailing Wang , Zhijian Wang , Zhitao Yuan , Lixia Li","doi":"10.1016/j.apt.2024.104746","DOIUrl":"10.1016/j.apt.2024.104746","url":null,"abstract":"<div><div>Serpentine is easily muddy and has a high zero electric point of zero charge (PZC), which leads to heterogeneous coagulation with pentlandite, which seriously affects the flotation of pentlandite. To solve this problem, from the new perspective of reducing the heterogeneous coagulation of pentlandite-serpentine and dispersing them, this study explored the influence of sodium tungstate as a dispersant on the dispersion of between pentlandite and serpentine using flotation tests, zeta potential tests, scanning electron microscope-energy dispersive spectrometer (SEM-EDS) examination, molecular dynamics simulation (MS), and calculations of the extended Derjaguin-Landau-Verwey-Overbeek (EDLVO) theory. The results show that −20 μm fine serpentine seriously deteriorates the flotation of pentlandite, while adding sodium tungstate can significantly promote the flotation separation of pentlandite and serpentine. MS simulation results showed that sodium tungstate could be chemisorbed with iron ions on the surface of pentlandite and mainly physisorbed with serpentine. EDLVO theoretical calculations show that after adsorption of sodium tungstate, the interaction between the two changed from attraction to repulsion at pH less than 10, and the mutual attraction was weakened at pH more significant than 10, thus weakening the heterogeneous coagulation between pentlandite and serpentine and causing serpentine to desorb from the surface of pentlandite, thus restoring the floatability of pentlandite, which SEM-EDS also confirmed. This provides a new insight into the dispersion mechanism of sodium tungstate as the innovative dispersant that is different from other dispersants for reducing heterogeneous coagulation of pentlandite and serpentine.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 1","pages":"Article 104746"},"PeriodicalIF":4.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div><div>The aim of this research is to fabricate nanocrystalline <span><math><mrow><msub><mrow><mi>C</mi><mi>u</mi></mrow><mi>x</mi></msub><msub><mrow><mi>C</mi><mi>o</mi></mrow><mrow><mn>1</mn><mo>-</mo><mi>x</mi></mrow></msub><msub><mrow><mi>F</mi><mi>e</mi></mrow><mn>2</mn></msub><msub><mi>O</mi><mn>4</mn></msub></mrow></math></span> materials, where x takes values of 0.1, 0.3, and 0.5, and to analyse how their structural, morphological, optoelectronic, vibrational, and magnetic properties change with varying levels of Cu<sup>2+</sup> doping. The preparation of copper-doped cobalt ferrite samples was conducted using the sol–gel method, with citric acid serving as a chelating agent. Powder X-ray diffraction measurements were conducted to identify the phase and structural attributes of the synthesized copper-doped cobalt ferrite. The Rietveld refinement clearly indicates the single-phase cubic structure, characterized by the Fd-3 m space group. The Debye Scherrer formula was used for the calculation of the crystallite size and it was discovered that the average crystallite size varied from ∼ 4.5 to 5.4 nm (which is less than 10 nm) as the doping concentration of Cu<sup>2+</sup> was increased. For the surface morphological studies, Field Emission Scanning Electron Microscopy (FESEM) was used, which suggest that all samples are well prepared and are spherical in nature. EDAX analysis validated the elemental composition with appropriate doping in crystalline samples of <span><math><mrow><msub><mrow><mi>C</mi><mi>u</mi></mrow><mi>x</mi></msub><msub><mrow><mi>C</mi><mi>o</mi></mrow><mrow><mn>1</mn><mo>-</mo><mi>x</mi></mrow></msub><msub><mrow><mi>F</mi><mi>e</mi></mrow><mn>2</mn></msub><msub><mi>O</mi><mn>4</mn></msub></mrow></math></span>. The existence of different chemical bonds has been verified by the Fourier Transform Infrared Rays (FTIR) Spectroscopy. The Raman spectra analysis indicated the existence of various vibrational modes within the sample, revealing the presence of four distinct Raman modes: A1g, Eg, and 2 T2g. Further, the Photoluminescence spectroscopy (PL) was utilized to explore the luminescent properties of the synthesized sample. The optical characteristics was studied using UV–Visible spectroscopy and it was observed that with an increase in the Cu<sup>2+</sup> concentration, the band gap decreased from 2.466 eV to 2.299 eV. X-ray photoelectron spectroscopy (XPS) was used to analyse the chemical states of the elements present in <span><math><mrow><msub><mrow><mi>C</mi><mi>u</mi></mrow><mi>x</mi></msub><msub><mrow><mi>C</mi><mi>o</mi></mrow><mrow><mn>1</mn><mo>-</mo><mi>x</mi></mrow></msub><msub><mrow><mi>F</mi><mi>e</mi></mrow><mn>2</mn></msub><msub><mi>O</mi><mn>4</mn></msub></mrow></math></span> nanoparticles. Furthermore, the magnetic characteristics of the synthesized copper-doped cobalt nanoferrites were examined using a Vibrating Sample Magnetometer (VSM). The hysteresis curves demonstrated low coercivity (H<sub>c</sub>
{"title":"Comprehensive analysis of Cu-doped CoFe2O4 nanocrystals: Structural, morphological, optoelectronic, and magnetic properties","authors":"Anchal , Sarita , Narendra Jakhar , P.A. Alvi , B.L. Choudhary","doi":"10.1016/j.apt.2024.104748","DOIUrl":"10.1016/j.apt.2024.104748","url":null,"abstract":"<div><div>The aim of this research is to fabricate nanocrystalline <span><math><mrow><msub><mrow><mi>C</mi><mi>u</mi></mrow><mi>x</mi></msub><msub><mrow><mi>C</mi><mi>o</mi></mrow><mrow><mn>1</mn><mo>-</mo><mi>x</mi></mrow></msub><msub><mrow><mi>F</mi><mi>e</mi></mrow><mn>2</mn></msub><msub><mi>O</mi><mn>4</mn></msub></mrow></math></span> materials, where x takes values of 0.1, 0.3, and 0.5, and to analyse how their structural, morphological, optoelectronic, vibrational, and magnetic properties change with varying levels of Cu<sup>2+</sup> doping. The preparation of copper-doped cobalt ferrite samples was conducted using the sol–gel method, with citric acid serving as a chelating agent. Powder X-ray diffraction measurements were conducted to identify the phase and structural attributes of the synthesized copper-doped cobalt ferrite. The Rietveld refinement clearly indicates the single-phase cubic structure, characterized by the Fd-3 m space group. The Debye Scherrer formula was used for the calculation of the crystallite size and it was discovered that the average crystallite size varied from ∼ 4.5 to 5.4 nm (which is less than 10 nm) as the doping concentration of Cu<sup>2+</sup> was increased. For the surface morphological studies, Field Emission Scanning Electron Microscopy (FESEM) was used, which suggest that all samples are well prepared and are spherical in nature. EDAX analysis validated the elemental composition with appropriate doping in crystalline samples of <span><math><mrow><msub><mrow><mi>C</mi><mi>u</mi></mrow><mi>x</mi></msub><msub><mrow><mi>C</mi><mi>o</mi></mrow><mrow><mn>1</mn><mo>-</mo><mi>x</mi></mrow></msub><msub><mrow><mi>F</mi><mi>e</mi></mrow><mn>2</mn></msub><msub><mi>O</mi><mn>4</mn></msub></mrow></math></span>. The existence of different chemical bonds has been verified by the Fourier Transform Infrared Rays (FTIR) Spectroscopy. The Raman spectra analysis indicated the existence of various vibrational modes within the sample, revealing the presence of four distinct Raman modes: A1g, Eg, and 2 T2g. Further, the Photoluminescence spectroscopy (PL) was utilized to explore the luminescent properties of the synthesized sample. The optical characteristics was studied using UV–Visible spectroscopy and it was observed that with an increase in the Cu<sup>2+</sup> concentration, the band gap decreased from 2.466 eV to 2.299 eV. X-ray photoelectron spectroscopy (XPS) was used to analyse the chemical states of the elements present in <span><math><mrow><msub><mrow><mi>C</mi><mi>u</mi></mrow><mi>x</mi></msub><msub><mrow><mi>C</mi><mi>o</mi></mrow><mrow><mn>1</mn><mo>-</mo><mi>x</mi></mrow></msub><msub><mrow><mi>F</mi><mi>e</mi></mrow><mn>2</mn></msub><msub><mi>O</mi><mn>4</mn></msub></mrow></math></span> nanoparticles. Furthermore, the magnetic characteristics of the synthesized copper-doped cobalt nanoferrites were examined using a Vibrating Sample Magnetometer (VSM). The hysteresis curves demonstrated low coercivity (H<sub>c</sub>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 1","pages":"Article 104748"},"PeriodicalIF":4.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-29DOI: 10.1016/j.apt.2024.104744
Feng Zhang, Ghislain Bournival, Seher Ata
Low-quality water is frequently used in coal preparation plants to conserve freshwater resources and lower operational costs. In the present work, a series of laboratory filtration experiments and subsequent μCT imaging of the filter cakes were conducted to link the effect of water quality on filtration performance and cake structure. Filtration experiments were carried out with three selected variables, including the slurry pH, salt concentration, which are the most important parameters of water quality, and the flocculant dosage. Filtration flowrate and cake moisture, the two most critical parameters, while examining filtration performance, were evaluated based on the filtration results. The slurry pH, salt concentration, and flocculant dosage were all found to significantly impact the flowrate, while the cake moisture was mainly affected by flocculant and salt concentration. These observed interactions were correlated with the results from filter cake µCT imaging. An increase in either salt concentration or the flocculant dosage was observed, which can cause a change in the pore structure of the cake, altering porosity, pore size, and specific surface area within the cake. Such changes in the pore structure resulted in changes in the specific cake resistance and the available water adsorption area, ultimately leading to changes in flowrate and moisture retention.
{"title":"The effects of water quality on the filtration performance of coal flotation product","authors":"Feng Zhang, Ghislain Bournival, Seher Ata","doi":"10.1016/j.apt.2024.104744","DOIUrl":"10.1016/j.apt.2024.104744","url":null,"abstract":"<div><div>Low-quality water is frequently used in coal preparation plants to conserve freshwater resources and lower operational costs. In the present work, a series of laboratory filtration experiments and subsequent <em>μ</em>CT imaging of the filter cakes were conducted to link the effect of water quality on filtration performance and cake structure. Filtration experiments were carried out with three selected variables, including the slurry pH, salt concentration, which are the most important parameters of water quality, and the flocculant dosage. Filtration flowrate and cake moisture, the two most critical parameters, while examining filtration performance, were evaluated based on the filtration results. The slurry pH, salt concentration, and flocculant dosage were all found to significantly impact the flowrate, while the cake moisture was mainly affected by flocculant and salt concentration. These observed interactions were correlated with the results from filter cake <em>µ</em>CT imaging. An increase in either salt concentration or the flocculant dosage was observed, which can cause a change in the pore structure of the cake, altering porosity, pore size, and specific surface area within the cake. Such changes in the pore structure resulted in changes in the specific cake resistance and the available water adsorption area, ultimately leading to changes in flowrate and moisture retention.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 1","pages":"Article 104744"},"PeriodicalIF":4.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-28DOI: 10.1016/j.apt.2024.104749
Lucia Baldino, Sonia Sarnelli, Ida Palazzo, Mariarosa Scognamiglio, Ernesto Reverchon
In this work, cannabidiol (CBD) nanoparticles contained in polyvinylpyrrolidone (PVP) microparticles (nano-in-micro system) were produced by supercritical CO2 assisted atomization (SAA) with the aim of improving CBD bioavailability. The experiments were performed by changing the total concentration of solute PVP + CBD and CBD/PVP mass ratio (R) to understand the effect of these parameters on CBD nanoparticle mean size, measured by a dynamic light scattering operating in a periodic manner. Nanoparticles as small as 33 nm were obtained, protected in PVP microparticles. CBD release tests were carried out to verify the increase in the solubilization rate of CBD nanoparticles: pure CBD powder was completely dissolved in about 240 min; whereas CBD 55 nm nanoparticles were completely released in 20 min.
{"title":"Production of cannabidiol nanoparticles loaded in polyvinylpyrrolidone microparticles by supercritical CO2 assisted atomization and dissolution enhancement effect","authors":"Lucia Baldino, Sonia Sarnelli, Ida Palazzo, Mariarosa Scognamiglio, Ernesto Reverchon","doi":"10.1016/j.apt.2024.104749","DOIUrl":"10.1016/j.apt.2024.104749","url":null,"abstract":"<div><div>In this work, cannabidiol (CBD) nanoparticles contained in polyvinylpyrrolidone (PVP) microparticles (nano-in-micro system) were produced by supercritical CO<sub>2</sub> assisted atomization (SAA) with the aim of improving CBD bioavailability. The experiments were performed by changing the total concentration of solute PVP + CBD and CBD/PVP mass ratio (R) to understand the effect of these parameters on CBD nanoparticle mean size, measured by a dynamic light scattering operating in a periodic manner. Nanoparticles as small as 33 nm were obtained, protected in PVP microparticles. CBD release tests were carried out to verify the increase in the solubilization rate of CBD nanoparticles: pure CBD powder was completely dissolved in about 240 min; whereas CBD 55 nm nanoparticles were completely released in 20 min.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 1","pages":"Article 104749"},"PeriodicalIF":4.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-26DOI: 10.1016/j.apt.2024.104745
Zankrut D. Vyas , Amit Sen , Abhishek Shetty , Gerardo Callegari , Fernando J. Muzzio , Sonia M. Razavi
Understanding bulk powder flow properties is crucial in pharmaceutical manufacturing to prevent material handling issues and ensure consistent product quality. Cohesion, a key factor influencing powder flow, is typically evaluated indirectly through methods such as the angle of repose and shear cell testing. This investigation explores the Warren Spring cohesion test, less common in the pharmaceutical industry, that directly measures powder cohesion. The test determines powder shear strength by rotating a paddle with vanes in a pre-compacted powder bed and applying torque without normal stress on the shear plane. The resulting Warren Spring cohesion strength, , was normalized by the conditioned bulk density, showing a strong linear correlation with the penetration force of the paddle. The slope of this relationship allows for a direct comparison of cohesion across materials. Notably, the was unaffected by pre-compaction stresses, demonstrating the consistency of this method. By controlling the penetration force, a simpler and faster method for testing cohesion across different powders was established. The correlation between the Warren Spring tester and the Brookfield powder flow tester was confirmed, highlighting the advantages of quicker assessments with the Warren Spring cohesion test, despite the shear cell’s greater sensitivity in certain situations.
了解散装粉末的流动特性对于制药业防止材料处理问题和确保产品质量稳定至关重要。内聚力是影响粉末流动的一个关键因素，通常通过休止角和剪切池测试等方法进行间接评估。本研究探讨了在制药行业不太常见的 Warren Spring 内聚力测试，该测试可直接测量粉末的内聚力。该试验通过在预压实的粉末床中旋转带叶片的桨叶，并在剪切面上施加不带法向应力的扭矩来确定粉末的剪切强度。得出的沃伦弹簧内聚强度（SWSC）按条件松密度归一化，显示出与桨的穿透力有很强的线性关系。通过这种关系的斜率可以直接比较不同材料的内聚力。值得注意的是，SWSC 不受压实前应力的影响，证明了这种方法的一致性。通过控制穿透力，建立了一种更简单、更快速的方法来测试不同粉末的内聚力。沃伦弹簧测试仪和布鲁克菲尔德粉末流动测试仪之间的相关性得到了证实，突出了沃伦弹簧内聚力测试更快评估的优势，尽管在某些情况下剪切池的灵敏度更高。
{"title":"Exploring pharmaceutical powder cohesion through the Warren Spring cohesion test","authors":"Zankrut D. Vyas , Amit Sen , Abhishek Shetty , Gerardo Callegari , Fernando J. Muzzio , Sonia M. Razavi","doi":"10.1016/j.apt.2024.104745","DOIUrl":"10.1016/j.apt.2024.104745","url":null,"abstract":"<div><div>Understanding bulk powder flow properties is crucial in pharmaceutical manufacturing to prevent material handling issues and ensure consistent product quality. Cohesion, a key factor influencing powder flow, is typically evaluated indirectly through methods such as the angle of repose and shear cell testing. This investigation explores the Warren Spring cohesion test, less common in the pharmaceutical industry, that directly measures powder cohesion. The test determines powder shear strength by rotating a paddle with vanes in a pre-compacted powder bed and<!--> <!-->applying torque without normal stress on the shear plane. The resulting Warren Spring cohesion strength, <span><math><mrow><msub><mi>S</mi><mrow><mi>WSC</mi></mrow></msub></mrow></math></span>, was normalized by the conditioned bulk density, showing a strong linear correlation with the penetration force of the paddle. The slope of this relationship allows for a<!--> <!-->direct comparison of cohesion across materials. Notably, the <span><math><mrow><msub><mi>S</mi><mrow><mi>WSC</mi></mrow></msub></mrow></math></span> was unaffected by pre-compaction stresses, demonstrating the consistency of this method. By controlling the penetration force, a simpler and faster method for testing cohesion across different powders was established. The correlation between the Warren Spring tester and the Brookfield powder flow tester was confirmed, highlighting the advantages of quicker assessments with the Warren Spring cohesion test, despite the shear cell’s greater sensitivity in certain situations.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-26DOI: 10.1016/j.apt.2024.104729
Tae-hyung Kim , Bora Ye , Myeung-jin Lee , Bora Jeong , Miyeon Yoo , Inkyung Cho , Aran Song , Heesoo Lee , Hong-Dae Kim
Binder jet additive manufacturing produces three-dimensional shapes by jetting a binder or activator onto a powder bed. For successful production of 3D-printed green body, it is crucial that the rheological properties of the powder are suitable for binder jetting. In this study, the addition of a small amount of hydrophilic nanosized silica fume controlled the flowability and wettability, enabling precise control of the rheological properties of the powder for binder jetting. Calcium aluminate cement (CAC) powder was introduced to the powder bed as a binder, and 97 % deionized water was used as an activator to manufacture a CAC-based ceramic green body (CT-G). CT-G underwent CO2 curing in a pressure reactor at 99.9 % CO2, 4 bar pressure, and > 60 % relative humidity, and at 25 ℃ for 2, 12, 24, 48, and 72 h (CT-xC). The CT-24C sample showed significantly improved mechanical properties after a short period of CO2 curing of 24 h, and successfully immobilizing 12 wt% CO2 within the CAC-based material matrix. This study presents an easily implementable method for rheological control of ceramic powder to achieve successful binder jetting.
{"title":"Rheology control of CO2 curable ceramic powder for binder jetting","authors":"Tae-hyung Kim , Bora Ye , Myeung-jin Lee , Bora Jeong , Miyeon Yoo , Inkyung Cho , Aran Song , Heesoo Lee , Hong-Dae Kim","doi":"10.1016/j.apt.2024.104729","DOIUrl":"10.1016/j.apt.2024.104729","url":null,"abstract":"<div><div>Binder jet additive manufacturing produces three-dimensional shapes by jetting a binder or activator onto a powder bed. For successful production of 3D-printed green body, it is crucial that the rheological properties of the powder are suitable for binder jetting. In this study, the addition of a small amount of hydrophilic nanosized silica fume controlled the flowability and wettability, enabling precise control of the rheological properties of the powder for binder jetting. Calcium aluminate cement (CAC) powder was introduced to the powder bed as a binder, and 97 % deionized water was used as an activator to manufacture a CAC-based ceramic green body (CT-G). CT-G underwent CO<sub>2</sub> curing in a pressure reactor at 99.9 % CO<sub>2</sub>, 4 bar pressure, and > 60 % relative humidity, and at 25 ℃ for 2, 12, 24, 48, and 72 h (CT-xC). The CT-24C sample showed significantly improved mechanical properties after a short period of CO<sub>2</sub> curing of 24 h, and successfully immobilizing 12 wt% CO<sub>2</sub> within the CAC-based material matrix. This study presents an easily implementable method for rheological control of ceramic powder to achieve successful binder jetting.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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