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Harnessing synthetic biology for energy-efficient bioinspired electronics: applications for logarithmic data converters. 利用合成生物学节能生物启发电子学:对数数据转换器的应用。
Pub Date : 2026-02-02 DOI: 10.1038/s44172-026-00589-5
Ilan Oren, Vishesh Gupta, Mouna Habib, Yizhak Shifman, Joseph Shor, Loai Danial, Ramez Daniel

Neuronal networks have driven advances in artificial intelligence, while molecular networks can provide powerful frameworks for energy-efficient information processing. Inspired by biological principles, we present a computational framework for mapping synthetic gene circuits into bio-inspired electronic architectures. In particular, we developed logarithmic Analog-to-Digital Converter (ADC), operating in current mode with a logarithmic encoding scheme, compresses an 80 dB dynamic range into three bits while consuming less than 1 µW, occupying only 0.02 mm², and operating at 4 kHz. Our bio-inspired approach achieves linear scaling of power, unlike conventional linear ADCs where power consumption increases exponentially with bit resolution, significantly improving efficiency in resource-constrained settings. Through a computational trade-off analysis, we demonstrate that logarithmic encoding maximizes spatial resource efficiency among power consumption and computational accuracy. By leveraging synthetic gene circuits as a model for efficient computation, this study provides a platform for the convergence of synthetic biology and bio-inspired electronic design.

神经网络推动了人工智能的进步,而分子网络可以为节能信息处理提供强大的框架。受生物学原理的启发,我们提出了一个计算框架,用于将合成基因电路映射到生物启发的电子结构中。特别是,我们开发了对数模数转换器(ADC),工作在电流模式下,采用对数编码方案,将80 dB动态范围压缩为3位,功耗小于1 μ W,占地面积仅为0.02 mm²,工作频率为4 kHz。我们的仿生方法实现了功率的线性缩放,不像传统的线性adc,功耗随着位分辨率呈指数级增长,显著提高了资源受限环境下的效率。通过计算权衡分析,我们证明对数编码在功耗和计算精度之间最大化空间资源效率。通过利用合成基因电路作为高效计算的模型,本研究为合成生物学和生物启发电子设计的融合提供了一个平台。
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引用次数: 0
Adaptive hierarchical learning for uncertainty-aware distributed energy resource planning. 不确定性感知分布式能源规划的自适应分层学习。
Pub Date : 2026-01-23 DOI: 10.1038/s44172-026-00591-x
Yue Xiang, Lingtao Li, Yu Lu, Alexis Pengfei Zhao, Youbo Liu, Xinying Wang, Tianjiao Pu, Chenghong Gu, Junyong Liu

The proliferation of distributed energy resources introduces multi-source uncertainties, including implicit uncertainties arising from third-party operators' partial observability of security constraints, challenging traditional distribution network planning methods dependent on model simplification and predefined scenarios. We address this gap via an adaptive hierarchical learning architecture that co-optimizes distributed energy resources location, capacity, and operational strategies data-drivenly, enabling autonomous learning of implicit constraints without full model knowledge. Our framework embeds a bi-level Stackelberg structure where Monte Carlo Tree Search autonomously generates planning schemes at the upper level, while multi-agent reinforcement learning directly learns operational policies from real-time data at the lower level under partial observability. Validation on both benchmark and large-scale practical distribution systems shows lower investment costs and faster solutions while maintaining voltage stability, demonstrating superior scalability and adaptiveness to implicit uncertainties versus scenario-based methods.

分布式能源的激增引入了多源不确定性,其中包括第三方运营商对安全约束的部分可观察性带来的隐性不确定性,这对传统的依赖于模型简化和预定义场景的配电网规划方法提出了挑战。我们通过自适应分层学习架构来解决这一差距,该架构以数据驱动的方式共同优化分布式能源资源的位置、容量和运营策略,从而在没有完整模型知识的情况下实现隐式约束的自主学习。我们的框架嵌入了一个双层Stackelberg结构,其中蒙特卡罗树搜索在上层自主生成规划方案,而多智能体强化学习在部分可观察性下直接从底层的实时数据中学习操作策略。在基准和大规模实际配电系统上的验证表明,在保持电压稳定的同时,投资成本更低,解决方案更快,与基于场景的方法相比,展示了卓越的可扩展性和对隐含不确定性的适应性。
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引用次数: 0
Cyber metasurface system for electromagnetic field closed-loop sensing and manipulation. 面向电磁场闭环传感与操纵的网络超表面系统。
Pub Date : 2026-01-23 DOI: 10.1038/s44172-026-00593-9
Xingqi Xuan, Bincai Wu, Yuqi Chen, Wangjie Cen, Yulin Zhou, Shilie Zheng, Xiaonan Hui, Xianmin Zhang

Intelligent metasurfaces, capable of shaping the electromagnetic field, have been extensively investigated in diverse scenarios, including beamforming, wireless communication, and electromagnetic imaging. Adaptable metasurface control is essential for their applications in practical communications engineering. Here we present a cyber-managed metasurface system to enhance the convenience of metasurface sub-array management, which integrates radio frequency energy harvesting with star-topology hybrid networks. By employing digitized phase-shifted transmission lines as tunable elements, the system not only enables electromagnetic manipulation and sensing capabilities but also achieves ultra-low power consumption. Each metasurface sub-array consists of 2 × 2 units, serving as a network node for data transmission and the sharing of harvested energy. Additionally, these metasurface sub-arrays, designed to resemble LEGO blocks, can be combined into various configurations, enabling flexible electromagnetic manipulation. The cyber-managed metasurface can be seamlessly integrated into wireless communication systems and passive wireless sensing networks, thereby providing versatility across diverse applications.

智能超表面,能够塑造电磁场,已经在各种场景中得到了广泛的研究,包括波束成形,无线通信和电磁成像。自适应超表面控制是其在实际通信工程中应用的必要条件。为了提高元表面子阵列管理的便利性,我们提出了一种网络管理的元表面系统,该系统将射频能量收集与星拓扑混合网络相结合。通过采用数字化相移传输线作为可调谐元件,系统不仅实现了电磁操纵和传感能力,而且实现了超低功耗。每个元表面子阵列由2 × 2单元组成,作为数据传输和能量共享的网络节点。此外,这些设计成类似乐高积木的超表面子阵列可以组合成各种配置,实现灵活的电磁操作。网络管理的超表面可以无缝集成到无线通信系统和无源无线传感网络中,从而提供跨各种应用的多功能性。
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引用次数: 0
Pilot full-scale demonstration of a prototype table-top neutron resonance transmission analysis system for nuclear material detection. 用于核材料探测的台式中子共振透射分析系统原型的中试全尺寸演示。
Pub Date : 2026-01-23 DOI: 10.1038/s44172-025-00564-6
Cebastien Joel Guembou Shouop, Harufumi Tsuchiya

Neutron Resonance Transmission Analysis (NRTA) is a highly sensitive, non-destructive technique for nuclear material characterisation, but its application has been limited by its reliance on large, fixed, and costly installations. Here, we present a compact mobile NRTA system utilising a small 252Cf spontaneous neutron source, designated as a prototype "table-top NRTA system", to analyse nuclear materials, offering a mobile and cost-effective alternative to accelerators or deuterium-tritium generators. The pilot system, measuring 130 cm × 50 cm × 50 cm with a 42 cm flight path, enables time-of-flight measurements on nuclear material samples. The system's performance was demonstrated through NRTA measurements of simulated samples, including indium, hafnium, and cadmium metal plates. The experimental transmission spectra were compared with theoretical predictions using the PHITS Monte Carlo simulation and the JENDL-5 nuclear data library, enabling isotope identification below 5 eV. The obtained results underscore the system's potential as a complementary tool for nuclear security and safeguards verification, particularly in scenarios where access to large accelerator or reactor facilities is impractical, and where mobility, compactness, and cost-effectiveness are prioritised over throughput.

中子共振透射分析(NRTA)是一种高灵敏度、非破坏性的核材料表征技术,但其应用受到大型、固定和昂贵装置的限制。在这里,我们提出了一个紧凑的移动NRTA系统,利用一个小的252Cf自发中子源,被指定为原型“桌面NRTA系统”,分析核材料,提供了一个移动和经济有效的替代加速器或氘-氚发生器。该先导系统尺寸为130厘米× 50厘米× 50厘米,飞行路径为42厘米,可对核材料样品进行飞行时间测量。该系统的性能通过NRTA测量模拟样品,包括铟,铪和镉金属板证明。利用PHITS蒙特卡罗模拟和JENDL-5核数据库将实验透射谱与理论预测进行了比较,实现了5 eV以下的同位素鉴定。获得的结果强调了该系统作为核安全和保障核查的补充工具的潜力,特别是在使用大型加速器或反应堆设施不切实际的情况下,以及机动性、紧凑性和成本效益优先于吞吐量的情况下。
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引用次数: 0
Battery management systems for vehicle electrification. 汽车电气化电池管理系统。
Pub Date : 2026-01-21 DOI: 10.1038/s44172-025-00572-6
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引用次数: 0
Detecting faulty lithium-ion cells in large-scale parallel battery packs using current distributions. 利用电流分布检测大型并联电池组中的故障锂离子电池。
Pub Date : 2026-01-21 DOI: 10.1038/s44172-025-00543-x
Pierre Lambert, Ross Drummond, Joseph P Ross, Eloise C Tredenick, David A Howey, Stephen R Duncan

One of the main concerns affecting the uptake of battery packs is safety, particularly with respect to fires caused by cell faults. Mitigating possible risks from faults requires advances in battery management systems and an understanding of the dynamics of large packs. To address this, a machine learning classifier based upon a support vector machine was developed that detects cell faults within large packs using a limited number of current sensors. To train the classifier, a modelling framework for parallel-connected packs is introduced and shown to generalise to Doyle-Fuller-Newman electrochemical models. The fault classification performance was found to be satisfactory, with an accuracy of 83% using current information from only 27% of the cells. Validation on experimental pack data is also shown. These results highlight the potential to combine mathematical modelling and machine learning to improve battery management systems and deal with the complexities of large packs.

影响电池组使用的主要问题之一是安全性,特别是电池故障引起的火灾。降低故障可能带来的风险需要电池管理系统的进步和对大型电池组动态的了解。为了解决这个问题,开发了一种基于支持向量机的机器学习分类器,该分类器使用有限数量的电流传感器检测大型包中的单元故障。为了训练分类器,引入了并行连接包的建模框架,并将其推广到多伊尔-富勒-纽曼电化学模型。发现故障分类性能令人满意,仅使用27%的单元的当前信息,准确率达到83%。并对实验包数据进行了验证。这些结果突出了将数学建模和机器学习结合起来改善电池管理系统和处理大型电池组复杂性的潜力。
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引用次数: 0
Network separation modeling and quantum computing for developing wildfire fuelbreak strategy. 基于网络分离建模和量子计算的野火断油策略研究。
Pub Date : 2026-01-19 DOI: 10.1038/s44172-026-00585-9
Samuel Dent, Kelsey Stoddard, Madison Smith, Andrew Strelzoff, Christopher Cummings, Jeffrey Cegan, Igor Linkov

Fuelbreak placement is an important consideration in fire management. Historically, strategies for placing fuelbreaks have fallen on the experience of fire managers such as by following ridgelines, and recent searches for a formal placement strategy have struggled to scale to large areas. Here we present a basic strategy utilizing equal graph partitioning and quantum computing to efficiently determine placements. By posing partitioning as a quadratic constrained binary optimization problem, D-Wave's hybrid quantum optimization tool could complete the task in seconds. Results for the examined area show two alternatives to the ridgeline method in a so-called worst-case fire scenario: one with 2.9% improvement in land separation equality while clearing 76 less acres, and another with a 12.4% improvement by clearing 19 more acres. In a selected subsection, D-Wave's hybrid solver performed faster than the SCIP solver but slower than the CPLEX solver, with the prospect for increased speed-up on larger problems. These findings demonstrate the effectiveness of equal graph partitioning for fuelbreak placement and the potential of D-Wave's hybrid solvers.

在火灾管理中,燃爆装置是一个重要的考虑因素。从历史上看,放置燃料休息的策略依赖于消防管理者的经验,比如沿着山脊线放置燃料休息,而最近对正式放置策略的研究一直难以推广到更大的区域。在这里,我们提出了一种利用相等图划分和量子计算的基本策略来有效地确定位置。D-Wave的混合量子优化工具将分区作为一个二次约束二进制优化问题,可以在几秒钟内完成任务。研究区域的结果显示,在所谓的最坏火灾情况下,山脊线法有两种替代方案:一种是在减少76英亩的同时,土地分离平等度提高2.9%;另一种是在增加19英亩的情况下,土地分离平等度提高12.4%。在选定的分段中,D-Wave的混合求解器比SCIP求解器执行得快,但比CPLEX求解器慢,在更大的问题上有望提高速度。这些发现证明了等图划分在燃料中断位置上的有效性,以及D-Wave混合求解器的潜力。
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引用次数: 0
Degradation modelling of chaotic systems via random walks in phase space. 混沌系统相空间随机游走的退化建模。
Pub Date : 2026-01-19 DOI: 10.1038/s44172-026-00587-7
Zhendan Lu, Cong Wang, Yawen Zhang, Yunxia Chen

Accurately predicting long-term degradation in chaotic systems remains a fundamental challenge due to their sensitive dependence on initial conditions and non-periodic dynamics. Conventional numerical models, which rely on fine time-step integration, are computationally demanding and prone to cumulative errors. Here we present a phase-space random walk framework for degradation modeling in chaotic systems. The approach characterizes local degradation velocity distributions through short-time averaging and reconstructs the long-term evolution as stochastic transitions across phase-space regions. Validation on chaotic electronic and mechanical systems demonstrates that the method improves computational efficiency by over two orders of magnitude while maintaining prediction errors below five percent. The analysis further reveals that chaotic systems experience transitions among dynamic regimes with varying degrees of chaos during degradation. This framework provides an efficient and generalizable way to modeling complex degradation processes, offering a other insights into the reliability design of electronic, mechanical, and mechatronic systems.

由于混沌系统对初始条件和非周期动力学的敏感依赖,准确预测混沌系统的长期退化仍然是一个根本性的挑战。传统的数值模型依赖于精细的时间步长积分,计算量大,容易产生累积误差。本文提出了一种用于混沌系统退化建模的相空间随机漫步框架。该方法通过短时平均表征局部退化速度分布,并将长期演化重构为跨相空间区域的随机转变。对混沌电子和机械系统的验证表明,该方法将计算效率提高了两个数量级以上,同时将预测误差保持在5%以下。进一步分析表明,混沌系统在退化过程中会经历不同混沌程度的动态状态之间的过渡。该框架为复杂退化过程的建模提供了一种有效且可推广的方法,为电子、机械和机电一体化系统的可靠性设计提供了另一种见解。
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引用次数: 0
Multi-contrast magnetic particle imaging for tomographic pH monitoring using stimuli-responsive hydrogels. 利用刺激响应水凝胶进行层析pH监测的多对比磁颗粒成像。
Pub Date : 2026-01-17 DOI: 10.1038/s44172-026-00586-8
Bruno Kluwe, Justin Ackers, Matthias Graeser, Anna C Bakenecker

Magnetic particle imaging (MPI) is a tomographic imaging technique which determines the spatial distribution of magnetic nanoparticles (MNPs). Multi-contrast MPI provides the ability to detect environmental conditions of MNPs, such as temperature or viscosity. One parameter that has not been investigated but shows high potential for medical diagnosis is the pH value, as it is an indicator of inflamed or tumorous tissue. In this work, we present an approach to resolve the pH value using multi-contrast MPI. Our proof-of-concept is based on a stimuli-responsive, magnetic hydrogel that exhibits reversible swelling in response to a pH change. The pH contrast is generated indirectly via the pH-responsive hydrogel swelling modulating the signal of embedded MNPs. Magnetic particle spectrometry measurements show that the hydrogels' magnetic response correlates with the pH value, which could provide a new way of contactless pH monitoring. Finally, the feasibility of resolving different pH values in a multi-contrast MPI image is demonstrated.

磁颗粒成像(MPI)是一种确定磁性纳米颗粒(MNPs)空间分布的层析成像技术。多重对比MPI提供了检测MNPs环境条件的能力,例如温度或粘度。一个尚未研究但具有很高医学诊断潜力的参数是pH值,因为它是炎症或肿瘤组织的指标。在这项工作中,我们提出了一种使用多对比度MPI来解决pH值的方法。我们的概念验证是基于一种刺激响应的磁性水凝胶,它在pH值变化时表现出可逆的肿胀。pH对比是通过pH响应水凝胶膨胀调节嵌入MNPs的信号间接产生的。磁粉谱测量结果表明,水凝胶的磁响应与pH值相关,为非接触式pH监测提供了一种新的方法。最后,验证了在多对比度MPI图像中分辨不同pH值的可行性。
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引用次数: 0
DeBCR: a sparsity-efficient framework for image enhancement through a deep-learning-based solution to inverse problems. DeBCR:通过基于深度学习的逆问题解决方案,用于图像增强的稀疏高效框架。
Pub Date : 2026-01-12 DOI: 10.1038/s44172-025-00582-4
Rui Li, Artsemi Yushkevich, Xiaofeng Chu, Mikhail Kudryashev, Artur Yakimovich

Computational image enhancement for microscopy facilitates cutting-edge biological discovery. While promising, the commonly used deep learning methods are computationally expensive owing to the use of general-purpose architectures, which are inefficient for microscopy data. Here, we propose a sparsity-efficient neural network for image enhancement as a deep representation learning solution to inverse problems in imaging. To maximize accessibility, we developed a framework named DeBCR, consisting of a modular Python library and a user-friendly point-and-click DeBCR plugin for Napari, a popular bioimage analysis tool. We provide a detailed protocol for using the DeBCR as a library and a plugin, including data preparation, training, and inference. We compare the image restoration performance of DeBCR to ten current state-of-the-art models over four publicly available datasets spanning crucial modalities in advanced light microscopy. DeBCR demonstrates more robust performance in denoising and deconvolution tasks across all assessed microscopy modalities while requiring notably fewer parameters than existing models.

显微镜的计算图像增强促进了前沿的生物学发现。虽然很有前途,但常用的深度学习方法由于使用通用架构而计算成本很高,这对于显微镜数据来说效率低下。在这里,我们提出了一种用于图像增强的稀疏高效神经网络,作为成像中逆问题的深度表示学习解决方案。为了最大限度地提高可访问性,我们开发了一个名为DeBCR的框架,它由一个模块化的Python库和一个用户友好的指向和点击DeBCR插件组成,用于Napari(一个流行的生物图像分析工具)。我们提供了使用DeBCR作为库和插件的详细协议,包括数据准备、训练和推理。我们将DeBCR的图像恢复性能与四个公开可用的数据集上的十个当前最先进的模型进行比较,这些数据集跨越了先进光学显微镜的关键模式。在所有评估的显微镜模式中,DeBCR在去噪和反褶积任务中表现出更强大的性能,同时需要的参数明显少于现有模型。
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引用次数: 0
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Communications engineering
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