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Phase-based computational adaptive optics enables artifact-free super-resolution microscopy. 基于相位的计算自适应光学实现无伪影的超分辨率显微镜。
Pub Date : 2026-03-09 DOI: 10.1038/s44172-026-00622-7
Atsushi Matsuda, Carlos Mario Rodriguez-Reza, Yosuke Tamada, Yamato Matsuo, Takaharu G Yamamoto, Takako Koujin, Peter M Carlton

Adaptive optics has revolutionized biological microscopy by improving resolution and signal-to-noise ratio, yet its reliance on complex hardware and phototoxic wavefront sensing limits broader adoption. Here, we introduce ∅CAO, a computational phase-based adaptive optics technique that corrects optical aberrations in three-dimensional fluorescence microscopy without requiring specialized optics or training datasets. By leveraging phase transfer functions in the frequency domain, ∅CAO enables robust post-acquisition correction across diverse imaging modalities, including wide-field and structured illumination microscopy. Our method achieves substantial improvements in image fidelity, supports subregional aberration correction, and maintains performance under noisy conditions. Demonstrated on a range of biological specimens, including Caenorhabditis elegans and plant tissues, ∅CAO offers a scalable and accessible solution for high-resolution biological imaging, facilitating the broad deployment of adaptive optics approaches across the life sciences.

自适应光学通过提高分辨率和信噪比彻底改变了生物显微镜,但它对复杂硬件和光毒性波前传感的依赖限制了其广泛采用。在这里,我们介绍∅CAO,一种基于计算相位的自适应光学技术,校正三维荧光显微镜中的光学像差,而不需要专门的光学或训练数据集。通过利用频域中的相传递函数,∅CAO能够跨各种成像方式进行稳健的采集后校正,包括宽视场和结构照明显微镜。我们的方法大大提高了图像保真度,支持分区域像差校正,并在噪声条件下保持性能。∅CAO在一系列生物标本上进行了演示,包括秀丽隐杆线虫和植物组织,∅CAO为高分辨率生物成像提供了可扩展和可访问的解决方案,促进了自适应光学方法在生命科学中的广泛部署。
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引用次数: 0
A concentric tube catheter for endoluminal interventions, steered and imaged via magnetic resonance imaging. 一种用于腔内干预的同心管导管,通过磁共振成像引导和成像。
Pub Date : 2026-03-09 DOI: 10.1038/s44172-026-00636-1
Peter Lloyd, Nikita Murasovs, Yael L May, Alistair Bacchetti, Benjamin Calmé, Joshua Davy, Vittorio Francescon, James H Chandler, Erica Dall'Armellina, Jurgen E Schneider, Pietro Valdastri

Two major challenges associated with robotic catheterization are, firstly, the provision of controllable degrees of freedom (DoFs) and, secondly, accessing feedback on the shape and pose of the catheter. Miniaturizable active steering can be achieved through magnetic actuation, and Magnetic Resonance Imaging (MRI) provides high definition, radiation-free 3D imaging that can be utilized for shape-sensing. Here, we propose a structurally adaptable Coaxial Sleeve Magnetic Actuator (CoSMA), with deformation energy provided by the background field of the MRI scanner. Our approach combines the magnetic actuation principle of the easy axis of alignment with the mechanical principles of concentric tube designs. This concept allows for a materially flexible (E=O(1MPa)), and therefore risk reduced, multi-DoF catheter. We demonstrate the CoSMA, constructed of three coaxial components with respective outer diameters of 4 mm, 1.5 mm and 0.4 mm, in an aortic arch phantom navigation within the bore of a pre-clinical MRI scanner.

与机器人导尿相关的两个主要挑战是,首先,提供可控自由度(dof),其次,获取导管形状和姿态的反馈。小型化的主动转向可以通过磁驱动实现,而磁共振成像(MRI)提供高清、无辐射的3D成像,可用于形状感应。本文提出了一种结构自适应的同轴套筒磁致动器(CoSMA),其变形能量由MRI扫描仪的背景场提供。我们的方法结合了易于对准轴的磁致动原理和同心管设计的机械原理。该概念允许材料柔性(E= 0 (1MPa)),因此风险降低,多自由度导管。我们展示了CoSMA,由三个同轴组件组成,外径分别为4mm, 1.5 mm和0.4 mm,在临床前MRI扫描仪内的主动脉弓幻影导航中。
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引用次数: 0
Transmissive metasurface with 3.5-μm-thick liquid crystals for subterahertz-wave dynamic beamforming. 3.5 μm厚液晶透射超表面用于亚太赫兹波动态波束形成。
Pub Date : 2026-03-09 DOI: 10.1038/s44172-026-00635-2
Daisuke Kitayama, Hibiki Kagami, Adam Pander, Yuto Hama, Hiroyuki Takahashi

Propagation control is essential for the practical use of subterahertz waves. Liquid crystal (LC) metasurfaces, which can be easily fabricated using display manufacturing technologies, can achieve the large aperture required for controlling propagation channels. Here we propose a dual-linear polarization unit cell that incorporates an LC layer with a thickness that can be determined independently of cell scaling, and that can be designed over a broad frequency range from microwave to subterahertz. Our prototype transmissive metasurface includes a 3.5-μm-thick LC layer and comprises 47,524 cells with a cell size below λ/8, and exhibits an insertion loss of 2.5 dB with a 3-dB bandwidth of 10%. We experimentally demonstrate two-dimensional beam steering up to 30 degrees and variable focusing through amplitude modulation of the aperture in the 115-GHz band. We anticipate that the development of metasurfaces with display-grade LC thickness will promote the industrial use of subterahertz bands in next-generation mobile communications.

传播控制对亚太赫兹波的实际应用至关重要。液晶(LC)超表面可以实现控制传播通道所需的大孔径,利用显示制造技术可以很容易地制造出来。在这里,我们提出了一种双线偏振单元电池,它包含一个厚度可以独立于电池缩放确定的LC层,并且可以在从微波到次太赫兹的宽频率范围内设计。我们的原型透射超表面包括一个3.5 μm厚的LC层,包含47,524个尺寸小于λ/8的单元,插入损耗为2.5 dB, 3db带宽为10%。我们通过实验证明了在115-GHz波段,通过孔径的振幅调制,可以实现30度的二维光束转向和可变聚焦。我们预计,具有显示级LC厚度的超表面的发展将促进次太赫兹频段在下一代移动通信中的工业应用。
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引用次数: 0
Pilot and testbed facilities: when the lab scale may not be enough. 试点和试验台设施:当实验室规模可能不够时。
Pub Date : 2026-03-07 DOI: 10.1038/s44172-026-00596-6
Jakob Kjøbsted Huusom, Helena Junicke, Joanna Morgan, Justin Searle, Darina Blagoeva, Thomas Malkow, Aurelien Pitois, Andreas Pfrang
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引用次数: 0
Percutaneous nephrostomy guidance by a convolutional-neural-network-based optical coherence tomography endoscope. 基于卷积神经网络的光学相干断层内窥镜引导经皮肾造口术。
Pub Date : 2026-03-06 DOI: 10.1038/s44172-026-00613-8
Chen Wang, Paul Calle, Feng Yan, Qinghao Zhang, Kar-Ming Fung, Zhongxin Yu, Sean G Duguay, William B Vanlandingham, Nathan A Bradley, Sanjay G Patel, Bradon Nave, Clint Hostetler, Ashley Milam, Chongle Pan, Qinggong Tang

Percutaneous nephrostomy is widely used in kidney access surgeries. Despite its prevalence in urological interventions, it presents two operational challenges: 1) precise needle placement into the renal pelvis; and 2) avoiding hemorrhage from blood vessel rupture. In this study, we developed an endoscopic optical coherence tomography probe for needle navigation. We conducted experiments on thirty-one human kidneys for two aspects: 1) tissue recognition, and 2) blood vessel detection. Experimental results indicated that renal tissues including cortex, medulla, calyx, sinus fat, and pelvis could be effectively distinguished through structural optical coherence tomography imaging, and renal blood flow could be detected through the Doppler function. Deep learning methods were utilized to automate recognition procedures. For tissue classification, an Inception model was used, achieving a recognition accuracy of 99.6%. For blood vessel detection, an nnU-net model was applied, exhibiting an intersection over union value of 0.8917 for blood vessel and 0.9916 for background.

经皮肾造口术广泛应用于肾脏通路手术。尽管它在泌尿外科干预中很流行,但它提出了两个操作挑战:1)精确地将针插入肾盂;2)避免血管破裂出血。在这项研究中,我们开发了一种用于针导航的内窥镜光学相干断层扫描探针。我们在31个人体肾脏上进行了两个方面的实验:1)组织识别,2)血管检测。实验结果表明,结构光学相干断层成像可有效区分肾皮质、髓质、花萼、窦脂肪、骨盆等肾组织,多普勒功能可检测肾血流。利用深度学习方法实现识别过程的自动化。对于组织分类,使用Inception模型,识别准确率达到99.6%。对于血管检测,采用nnU-net模型,血管的交叉union值为0.8917,背景的交叉union值为0.9916。
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引用次数: 0
A wireless power transfer system for leadless endovascular electrocorticography. 一种用于无铅血管内皮质电成像的无线电力传输系统。
Pub Date : 2026-03-06 DOI: 10.1038/s44172-026-00617-4
Zhangyu Xu, Nhan Duy Truong, Arman Ahnood, Armin Nikpour, Omid Kavehei

Wireless power transfer (WPT) for stent-based neuroprosthetic devices, such as endovascular electrocorticography (endoECoG) systems, is typically constrained by the need for long lead wires to subcutaneous chest implants. This study presents a method for delivering power directly to an unmodified medical stent. The proposed system employs a subcutaneous relay that converts inductive coupling to capacitive coupling, thereby improving power transfer efficiency, reducing invasiveness, and mitigating instability in skin-contact capacitance. Experimental validation using skin, bone, and vessel tissues, combined with finite element simulations, demonstrated over 45 mW of delivered power, sufficient for endoECoG and biosignal sensing. The proposed system achieved 7.26% DC-to-DC efficiency, the highest reported for stent-based implants without custom stents or auxiliary transceivers. Measured results closely matched simulations, validating the experiment results. Safety assessments, including specific absorption rate and thermal analysis, confirmed compliance with regulatory limits. While the experimental results indicate robust performance, further theoretical analysis is required to establish a complete mechanistic understanding of the underlying coupling processes. The proposed architecture enables efficient, safe, and fully wireless power delivery to endovascular implants without requiring close skin contact, supporting long-term implantation, enhancing patient comfort, and facilitating future clinical translation.

无线电力传输(WPT)用于基于支架的神经假体装置,如血管内皮质电成像(endoECoG)系统,通常受到需要长引线到皮下胸部植入物的限制。本研究提出了一种直接向未经修饰的医用支架输送能量的方法。该系统采用皮下继电器,将电感耦合转换为电容耦合,从而提高功率传输效率,减少侵入性,并减轻皮肤接触电容的不稳定性。利用皮肤、骨骼和血管组织进行的实验验证,结合有限元模拟,证明了超过45兆瓦的输出功率,足以用于endoECoG和生物信号传感。该系统实现了7.26%的dc - dc效率,是无定制支架或辅助收发器的支架植入物中最高的。测量结果与模拟结果吻合较好,验证了实验结果。安全评估,包括特定吸收率和热分析,确认符合法规限制。虽然实验结果显示了稳健的性能,但需要进一步的理论分析来建立对潜在耦合过程的完整机制理解。该架构可实现高效、安全、完全无线的血管内植入物供电,无需与皮肤密切接触,支持长期植入,提高患者舒适度,并促进未来的临床转化。
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引用次数: 0
3D-printed concrete with in-process embedded fiber-reinforced polymer grid reinforcement. 3d打印混凝土与在过程中嵌入纤维增强聚合物网格增强。
Pub Date : 2026-03-05 DOI: 10.1038/s44172-026-00628-1
Hou-Qi Sun, Shan-Shan Xie, Jun-Jie Zeng, Yan Zhuge

The absence of effective reinforcement has hindered the widespread use of 3D-printed concrete. In this study, we propose an innovative in-process embedding technology that enables the simultaneous printing of concrete and flexible fiber-reinforced polymer grids. We investigate the performance of grids as reinforcement in 3D-printed concrete through pull-out and splitting tensile tests to assess the bonding properties between the grids and concrete. Additionally, three-point bending tests were conducted to evaluate the impact of grids on the flexural performance of 3D-printed concrete plates. Test results show that the load-bearing capacity and deflection of 3D-printed concrete plates reinforced with grids increased by approximately 41% and 552%, respectively. However, the voids and reduced contact area caused by the simultaneous printing of the grids weakened the bonding between adjacent concrete layers. Overall, the findings confirm the feasibility of the proposed in-process embedding technology and demonstrate its protential to advance 3D-printed concrete structures through the effective integration of in-processfiber-reinforced polymer reinforcement.

缺乏有效的钢筋阻碍了3d打印混凝土的广泛使用。在这项研究中,我们提出了一种创新的过程嵌入技术,可以同时打印混凝土和柔性纤维增强聚合物网格。我们通过拉出和劈裂拉伸试验来研究网格作为3d打印混凝土中的钢筋的性能,以评估网格和混凝土之间的粘合性能。此外,还进行了三点弯曲试验,以评估网格对3d打印混凝土板抗弯性能的影响。试验结果表明,3d打印加筋混凝土板的承载力和挠度分别提高了约41%和552%。然而,同时打印网格造成的空洞和减少的接触面积削弱了相邻混凝土层之间的结合。总体而言,研究结果证实了所提出的过程中嵌入技术的可行性,并展示了其通过有效集成过程中纤维增强聚合物增强来推进3d打印混凝土结构的潜力。
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引用次数: 0
Non-contact electroelastic modulation of conventional media leveraging two-way electromagnetic induction. 利用双向电磁感应的传统介质的非接触电弹性调制。
Pub Date : 2026-03-05 DOI: 10.1038/s44172-026-00630-7
Joshua Dupont, Richard Christenson, Jiong Tang

This research reports the synthesis of a wave altering non-contact design. Resonators enable vibration and wave modulation, but typically require mechanical attachments that modify host properties and limit retrofit. Inspired by remote field technologies, we introduce a tunable non-contact resonator that traps propagating wavefronts and suppresses targeted modes in elastic structures. Eddy-current interactions provide remote, bidirectional coupling between structural vibrations and coil voltage. Analog impedance converters tune the shunt impedance, establishing LC-resonance at select frequencies while compensating for dissipative loss. In this manner, local resonance is induced on electrically conductive media, facilitating tunable dispersion and modal suppression. Intrinsic host properties are preserved, facilitating non-intrusive elastodynamic control for in-service retrofit, delicate structures, and challenging environments. Analytical modeling predicts underlying electromagnetics and structural dynamics, informing electrical tunings while highlighting functional dependencies. Experiments demonstrate tunable suppression and wave-blocking, unveiling constraints and improvement paths. The results establish a foundation for adaptive, non-contact elastic metamaterials.

本研究报告了一种改变波的非接触设计的合成。谐振器可以实现振动和波调制,但通常需要机械附件来修改主机属性并限制改造。受远程场技术的启发,我们引入了一种可调谐的非接触式谐振器,可以捕获传播波前并抑制弹性结构中的目标模式。涡流相互作用在结构振动和线圈电压之间提供远程双向耦合。模拟阻抗转换器调整分流阻抗,在补偿耗散损耗的同时,在选定频率建立lc谐振。通过这种方式,在导电介质上诱导局部共振,促进可调色散和模态抑制。保留了宿主的固有特性,为在役改造、精细结构和具有挑战性的环境提供了非侵入式弹性动力学控制。分析建模预测潜在的电磁和结构动力学,在强调功能依赖的同时通知电气调谐。实验证明了可调的抑制和阻波,揭示了约束条件和改进途径。研究结果为自适应非接触弹性超材料的研究奠定了基础。
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引用次数: 0
Magnetic field control with dual robotic tunable magnetic end effectors. 双机器人可调谐磁末端执行器的磁场控制。
Pub Date : 2026-03-04 DOI: 10.1038/s44172-026-00629-0
Kiana Abolfathi, Jiacheng Zhu, James H Chandler, Keyoumars Ashkan, Pietro Valdastri, Hongsoo Choi, Xiaojun Zhai, Ali Kafash Hoshiar

Magnetic manipulation is increasingly used in medical applications for its potential in remote control. However, precise magnetic field generation in large workspaces remains challenging. This paper introduces an adaptive robotic end effector, the tunable magnetic end effector (TME), capable of generating spatially controllable magnetic fields. By integrating permanent magnets, the TME enables accurate magnetic control for wireless manipulation of miniaturized medical devices. Compared to standard switchable permanent magnets, TME offers enhanced field control suited for delicate operations. Finite element (FEM) simulations and experiments confirm reliable ON/OFF field switching, showing a 7.2% average error. Key design parameters (magnet size, material, and arrangement) were optimized via simulation. An artificial neural network (ANN), trained on spatial, rotational, and magnetic data, enables adaptive control. Proof-of-concept demos include steering millimeter-scale magnetic carriers, shaping magnetic soft robots, and directing magnetic nanoparticle swarms. The dual-TME configuration further expands the effective manipulation workspace and enables dynamic switching of magnetic field directions across different regions, thereby enhancing the system's applicability.

磁操纵因其在远程控制方面的潜力而越来越多地应用于医疗领域。然而,在大型工作空间中精确地产生磁场仍然具有挑战性。介绍了一种能够产生空间可控磁场的自适应机器人末端执行器——可调谐磁末端执行器(TME)。通过集成永磁体,TME可以对微型医疗设备进行精确的磁控制。与标准的可切换永磁体相比,TME提供了适合精细操作的增强磁场控制。有限元仿真和实验验证了该开关的可靠性,平均误差为7.2%。通过仿真优化了关键设计参数(磁体尺寸、材料和排列)。人工神经网络(ANN),训练空间,旋转和磁数据,使自适应控制。概念验证演示包括操纵毫米级磁性载体,塑造磁性软机器人,以及引导磁性纳米粒子群。双tme结构进一步扩展了有效操作工作空间,实现了不同区域磁场方向的动态切换,增强了系统的适用性。
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引用次数: 0
X-ray fluorescence spectroscopy for rapid identification of cathode chemistry in lithium-ion battery recycling. 锂离子电池回收过程中阴极化学的x射线荧光光谱快速鉴定。
Pub Date : 2026-03-02 DOI: 10.1038/s44172-026-00618-3
Feihong Ren, Vladimir Vidal, Andréa Campos, Florence Vacandio, Bernard Angeletti, Isabelle Giffard, Perrine Chaurand, Daniel Borschneck, Suanto Syahputra, Jérôme Rose, Ismael Saadoune, Clément Levard

Efficient identification of cathode chemistry in end-of-life lithium-ion batteries is essential for enabling effective battery recycling. Current approaches often rely on battery disassembly or time-consuming testing, limiting their practical use at scale. Here we report a rapid classification strategy based on X-ray fluorescence spectroscopy combined with statistical analysis. A reference dataset was established from high-quality elemental spectra collected from more than 100 end-of-life lithium-ion batteries. Statistical grouping was used to define cathode categories, which were validated by selective disassembly and complementary chemical analysis. The trained classification model was then applied to newly acquired spectra collected within seconds per battery, enabling fast identification without additional disassembly. The approach achieves high prediction accuracy across the studied dataset and demonstrates the feasibility of rapid cathode identification for battery recycling applications.

有效识别报废锂离子电池的阴极化学是实现电池有效回收的关键。目前的方法通常依赖于电池拆卸或耗时的测试,限制了它们的大规模实际应用。本文报道了一种基于x射线荧光光谱与统计分析相结合的快速分类策略。从100多个报废锂离子电池中收集的高质量元素光谱建立了参考数据集。采用统计分组法确定阴极分类,并通过选择性拆解和互补化学分析进行验证。然后将训练好的分类模型应用于在每个电池几秒钟内收集的新获得的光谱,从而实现快速识别,而无需额外的拆卸。该方法在研究数据集上实现了较高的预测精度,并证明了电池回收应用中快速阴极识别的可行性。
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引用次数: 0
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Communications engineering
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