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Detecting faulty lithium-ion cells in large-scale parallel battery packs using current distributions. 利用电流分布检测大型并联电池组中的故障锂离子电池。
Pub Date : 2026-01-21 DOI: 10.1038/s44172-025-00543-x
Pierre Lambert, Ross Drummond, Joseph P Ross, Eloise C Tredenick, David A Howey, Stephen R Duncan

One of the main concerns affecting the uptake of battery packs is safety, particularly with respect to fires caused by cell faults. Mitigating possible risks from faults requires advances in battery management systems and an understanding of the dynamics of large packs. To address this, a machine learning classifier based upon a support vector machine was developed that detects cell faults within large packs using a limited number of current sensors. To train the classifier, a modelling framework for parallel-connected packs is introduced and shown to generalise to Doyle-Fuller-Newman electrochemical models. The fault classification performance was found to be satisfactory, with an accuracy of 83% using current information from only 27% of the cells. Validation on experimental pack data is also shown. These results highlight the potential to combine mathematical modelling and machine learning to improve battery management systems and deal with the complexities of large packs.

影响电池组使用的主要问题之一是安全性,特别是电池故障引起的火灾。降低故障可能带来的风险需要电池管理系统的进步和对大型电池组动态的了解。为了解决这个问题,开发了一种基于支持向量机的机器学习分类器,该分类器使用有限数量的电流传感器检测大型包中的单元故障。为了训练分类器,引入了并行连接包的建模框架,并将其推广到多伊尔-富勒-纽曼电化学模型。发现故障分类性能令人满意,仅使用27%的单元的当前信息,准确率达到83%。并对实验包数据进行了验证。这些结果突出了将数学建模和机器学习结合起来改善电池管理系统和处理大型电池组复杂性的潜力。
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引用次数: 0
Network separation modeling and quantum computing for developing wildfire fuelbreak strategy. 基于网络分离建模和量子计算的野火断油策略研究。
Pub Date : 2026-01-19 DOI: 10.1038/s44172-026-00585-9
Samuel Dent, Kelsey Stoddard, Madison Smith, Andrew Strelzoff, Christopher Cummings, Jeffrey Cegan, Igor Linkov

Fuelbreak placement is an important consideration in fire management. Historically, strategies for placing fuelbreaks have fallen on the experience of fire managers such as by following ridgelines, and recent searches for a formal placement strategy have struggled to scale to large areas. Here we present a basic strategy utilizing equal graph partitioning and quantum computing to efficiently determine placements. By posing partitioning as a quadratic constrained binary optimization problem, D-Wave's hybrid quantum optimization tool could complete the task in seconds. Results for the examined area show two alternatives to the ridgeline method in a so-called worst-case fire scenario: one with 2.9% improvement in land separation equality while clearing 76 less acres, and another with a 12.4% improvement by clearing 19 more acres. In a selected subsection, D-Wave's hybrid solver performed faster than the SCIP solver but slower than the CPLEX solver, with the prospect for increased speed-up on larger problems. These findings demonstrate the effectiveness of equal graph partitioning for fuelbreak placement and the potential of D-Wave's hybrid solvers.

在火灾管理中,燃爆装置是一个重要的考虑因素。从历史上看,放置燃料休息的策略依赖于消防管理者的经验,比如沿着山脊线放置燃料休息,而最近对正式放置策略的研究一直难以推广到更大的区域。在这里,我们提出了一种利用相等图划分和量子计算的基本策略来有效地确定位置。D-Wave的混合量子优化工具将分区作为一个二次约束二进制优化问题,可以在几秒钟内完成任务。研究区域的结果显示,在所谓的最坏火灾情况下,山脊线法有两种替代方案:一种是在减少76英亩的同时,土地分离平等度提高2.9%;另一种是在增加19英亩的情况下,土地分离平等度提高12.4%。在选定的分段中,D-Wave的混合求解器比SCIP求解器执行得快,但比CPLEX求解器慢,在更大的问题上有望提高速度。这些发现证明了等图划分在燃料中断位置上的有效性,以及D-Wave混合求解器的潜力。
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引用次数: 0
Degradation modelling of chaotic systems via random walks in phase space. 混沌系统相空间随机游走的退化建模。
Pub Date : 2026-01-19 DOI: 10.1038/s44172-026-00587-7
Zhendan Lu, Cong Wang, Yawen Zhang, Yunxia Chen

Accurately predicting long-term degradation in chaotic systems remains a fundamental challenge due to their sensitive dependence on initial conditions and non-periodic dynamics. Conventional numerical models, which rely on fine time-step integration, are computationally demanding and prone to cumulative errors. Here we present a phase-space random walk framework for degradation modeling in chaotic systems. The approach characterizes local degradation velocity distributions through short-time averaging and reconstructs the long-term evolution as stochastic transitions across phase-space regions. Validation on chaotic electronic and mechanical systems demonstrates that the method improves computational efficiency by over two orders of magnitude while maintaining prediction errors below five percent. The analysis further reveals that chaotic systems experience transitions among dynamic regimes with varying degrees of chaos during degradation. This framework provides an efficient and generalizable way to modeling complex degradation processes, offering a other insights into the reliability design of electronic, mechanical, and mechatronic systems.

由于混沌系统对初始条件和非周期动力学的敏感依赖,准确预测混沌系统的长期退化仍然是一个根本性的挑战。传统的数值模型依赖于精细的时间步长积分,计算量大,容易产生累积误差。本文提出了一种用于混沌系统退化建模的相空间随机漫步框架。该方法通过短时平均表征局部退化速度分布,并将长期演化重构为跨相空间区域的随机转变。对混沌电子和机械系统的验证表明,该方法将计算效率提高了两个数量级以上,同时将预测误差保持在5%以下。进一步分析表明,混沌系统在退化过程中会经历不同混沌程度的动态状态之间的过渡。该框架为复杂退化过程的建模提供了一种有效且可推广的方法,为电子、机械和机电一体化系统的可靠性设计提供了另一种见解。
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引用次数: 0
Multi-contrast magnetic particle imaging for tomographic pH monitoring using stimuli-responsive hydrogels. 利用刺激响应水凝胶进行层析pH监测的多对比磁颗粒成像。
Pub Date : 2026-01-17 DOI: 10.1038/s44172-026-00586-8
Bruno Kluwe, Justin Ackers, Matthias Graeser, Anna C Bakenecker

Magnetic particle imaging (MPI) is a tomographic imaging technique which determines the spatial distribution of magnetic nanoparticles (MNPs). Multi-contrast MPI provides the ability to detect environmental conditions of MNPs, such as temperature or viscosity. One parameter that has not been investigated but shows high potential for medical diagnosis is the pH value, as it is an indicator of inflamed or tumorous tissue. In this work, we present an approach to resolve the pH value using multi-contrast MPI. Our proof-of-concept is based on a stimuli-responsive, magnetic hydrogel that exhibits reversible swelling in response to a pH change. The pH contrast is generated indirectly via the pH-responsive hydrogel swelling modulating the signal of embedded MNPs. Magnetic particle spectrometry measurements show that the hydrogels' magnetic response correlates with the pH value, which could provide a new way of contactless pH monitoring. Finally, the feasibility of resolving different pH values in a multi-contrast MPI image is demonstrated.

磁颗粒成像(MPI)是一种确定磁性纳米颗粒(MNPs)空间分布的层析成像技术。多重对比MPI提供了检测MNPs环境条件的能力,例如温度或粘度。一个尚未研究但具有很高医学诊断潜力的参数是pH值,因为它是炎症或肿瘤组织的指标。在这项工作中,我们提出了一种使用多对比度MPI来解决pH值的方法。我们的概念验证是基于一种刺激响应的磁性水凝胶,它在pH值变化时表现出可逆的肿胀。pH对比是通过pH响应水凝胶膨胀调节嵌入MNPs的信号间接产生的。磁粉谱测量结果表明,水凝胶的磁响应与pH值相关,为非接触式pH监测提供了一种新的方法。最后,验证了在多对比度MPI图像中分辨不同pH值的可行性。
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引用次数: 0
DeBCR: a sparsity-efficient framework for image enhancement through a deep-learning-based solution to inverse problems. DeBCR:通过基于深度学习的逆问题解决方案,用于图像增强的稀疏高效框架。
Pub Date : 2026-01-12 DOI: 10.1038/s44172-025-00582-4
Rui Li, Artsemi Yushkevich, Xiaofeng Chu, Mikhail Kudryashev, Artur Yakimovich

Computational image enhancement for microscopy facilitates cutting-edge biological discovery. While promising, the commonly used deep learning methods are computationally expensive owing to the use of general-purpose architectures, which are inefficient for microscopy data. Here, we propose a sparsity-efficient neural network for image enhancement as a deep representation learning solution to inverse problems in imaging. To maximize accessibility, we developed a framework named DeBCR, consisting of a modular Python library and a user-friendly point-and-click DeBCR plugin for Napari, a popular bioimage analysis tool. We provide a detailed protocol for using the DeBCR as a library and a plugin, including data preparation, training, and inference. We compare the image restoration performance of DeBCR to ten current state-of-the-art models over four publicly available datasets spanning crucial modalities in advanced light microscopy. DeBCR demonstrates more robust performance in denoising and deconvolution tasks across all assessed microscopy modalities while requiring notably fewer parameters than existing models.

显微镜的计算图像增强促进了前沿的生物学发现。虽然很有前途,但常用的深度学习方法由于使用通用架构而计算成本很高,这对于显微镜数据来说效率低下。在这里,我们提出了一种用于图像增强的稀疏高效神经网络,作为成像中逆问题的深度表示学习解决方案。为了最大限度地提高可访问性,我们开发了一个名为DeBCR的框架,它由一个模块化的Python库和一个用户友好的指向和点击DeBCR插件组成,用于Napari(一个流行的生物图像分析工具)。我们提供了使用DeBCR作为库和插件的详细协议,包括数据准备、训练和推理。我们将DeBCR的图像恢复性能与四个公开可用的数据集上的十个当前最先进的模型进行比较,这些数据集跨越了先进光学显微镜的关键模式。在所有评估的显微镜模式中,DeBCR在去噪和反褶积任务中表现出更强大的性能,同时需要的参数明显少于现有模型。
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引用次数: 0
Microengineering of the capillary interface of midbrain dopaminergic neurons to study Parkinson's disease vascular alterations. 中脑多巴胺能神经元毛细血管界面的微工程研究帕金森病血管改变。
Pub Date : 2026-01-10 DOI: 10.1038/s44172-025-00581-5
Anika Alim, Yoongyeong Baek, Myungwoon Lee, Jungwook Paek

Parkinson's Disease (PD) involves not only α-synuclein pathology in dopaminergic neurons but also vascular impairments that remain underexplored due to limitations of traditional in vitro models. Here we present a microengineered 3D neurovascular midbrain model that reconstructs the capillary interface of substantia nigra dopaminergic neurons. In our proof-of-concept demonstration, we successfully recapitulated neuronal pathology in PD, including α-synuclein aggregation, inflammatory responses, and progressive neuronal degeneration, by exposing our model to specially generated PD-associated α-synuclein preformed-fibrils. Importantly, this engineering approach also enables the investigation of progressive vascular abnormalities in PD, such as endothelial dysfunction, barrier disruption, vascular regression, and the resulting impairment of blood flow. Our PD model establishes a tractable platform for investigating the multifaceted nature of the disease and understanding the complex interplay between neurodegeneration and vascular pathology, offering a unique tool for developing innovative therapeutic strategies that address both the neuronal and vascular components of PD pathology.

帕金森氏病(PD)不仅涉及多巴胺能神经元的α-突触核蛋白病理,而且由于传统体外模型的局限性,血管损伤尚未得到充分的研究。在这里,我们提出了一个微工程的三维神经血管中脑模型,重建黑质多巴胺能神经元的毛细血管界面。在我们的概念验证演示中,我们通过将我们的模型暴露于特殊生成的PD相关α-突触核蛋白预先形成的原纤维中,成功地再现了PD的神经病理学,包括α-突触核蛋白聚集、炎症反应和进行性神经元变性。重要的是,这种工程方法还可以研究PD的进行性血管异常,如内皮功能障碍、屏障破坏、血管退化以及由此导致的血流障碍。我们的PD模型为研究疾病的多面性和理解神经变性和血管病理之间的复杂相互作用建立了一个易于处理的平台,为开发创新的治疗策略提供了一个独特的工具,可以解决PD病理的神经元和血管成分。
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引用次数: 0
Accelerating CEST MRI through complementary undersampling and multi-offset transformer reconstruction. 通过互补欠采样和多偏置变压器重建加速CEST MRI。
Pub Date : 2026-01-10 DOI: 10.1038/s44172-025-00580-6
Huabing Liu, Zilin Chen, Lok Hin Law, Yang Liu, Ziyan Wang, Jiawen Wang, Yi Zhang, Dinggang Shen, Jianpan Huang, Kannie Wai Yan Chan

Chemical exchange saturation transfer (CEST) is a promising magnetic resonance imaging (MRI) technique that provides molecular-level information in vivo. To obtain this unique contrast, repeated acquisition at multiple frequency offsets is needed, resulting a long scanning time. In this study, we propose a hybrid strategy at k-space and image domain to accelerate CEST MRI to facilitate its wider application. In k-space, we developed a complementary undersampling strategy which enforces adjacent frequency offsets by acquiring different subregions of k-space. Both Cartesian and spiral k-space trajectories were applied to validate its effectiveness. In the image domain, we developed a multi-offset transformer reconstruction network that uses complementary information from adjacent frequency offsets to improve reconstruction performance. Additionally, we introduced a data consistency layer to preserve undersampled k-space and a differentiable coil combination layer to leverage multi-coil information. The proposed method was evaluated on rodent brain and multi-coil human brain CEST images from both pre-clinical and clinical 3 T MRI scanners. Compared to fully-sampled images, our method outperforms a number of state-of-the-art CEST MRI reconstruction methods in both accuracy and image fidelity. CEST maps, including amide proton transfer (APT) and relayed nuclear Overhauser enhancement (rNOE), were calculated. The results also showed close agreement with fully-sampled ones.

化学交换饱和转移(CEST)是一种很有前途的磁共振成像(MRI)技术,可以提供体内分子水平的信息。为了获得这种独特的对比度,需要在多个频率偏移处重复采集,从而导致较长的扫描时间。在本研究中,我们提出了k空间和图像域的混合策略来加速CEST MRI,以促进其更广泛的应用。在k空间中,我们开发了一种互补的欠采样策略,通过获取k空间的不同子区域来强制相邻的频率偏移。应用了笛卡尔和螺旋k空间轨迹来验证其有效性。在图像域,我们开发了一个多偏置变压器重建网络,利用相邻频率偏移的互补信息来提高重建性能。此外,我们引入了一个数据一致性层来保护欠采样k空间,并引入了一个可微线圈组合层来利用多线圈信息。在临床前和临床3t MRI扫描仪上对啮齿动物大脑和多线圈人脑CEST图像进行了评估。与全采样图像相比,我们的方法在准确性和图像保真度方面优于许多最先进的CEST MRI重建方法。计算CEST图,包括酰胺质子转移(APT)和中继核Overhauser增强(rNOE)。结果也显示与完全抽样的结果非常一致。
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引用次数: 0
Enhancing energy capture: single- and dual-chamber oscillating water column devices under converging waves. 增强能量捕获:汇聚波下的单室和双室振荡水柱装置。
Pub Date : 2026-01-10 DOI: 10.1038/s44172-026-00584-w
Yu Zhou, Zhigao Wang, Jing Geng

A parabolic coast or wall concentrates incoming waves at its focal point, creating a high‑energy zone ideal for enhanced capture. Yet, how to efficiently harvest this concentrated energy remains unclear. Here we propose designs of single- and dual-chamber Oscillating Water Column (OWC) chambers for enhancing wave energy capture. A time‑domain higher‑order boundary element method, grounded in nonlinear potential flow theory, is coupled with a nonlinear pneumatic model-calibrated via geometric scaling, dual‑chamber coupling, and focused‑wave boundary tests-to simulate OWC performance. Under parabolic focusing, a bimodal resonance yields peak power absorption up to 17 times that of an isolated device, and a leeward perforation design boosts the single‑chamber capture ratio to 25 times baseline. A dual‑chamber configuration with an added semicircular chamber further elevates total absorbed energy and widens the effective bandwidth. This work provides practical design guidance for efficient wave-energy devices operating in focused-wave environments.

抛物线海岸或墙壁将入射波集中在其焦点上,形成一个高能量区,非常适合增强捕获。然而,如何有效地收集这种集中的能源仍不清楚。在这里,我们提出了单室和双室振荡水柱(OWC)室的设计,以提高波浪能捕获。基于非线性势流理论的时域高阶边界元方法与非线性气动模型相结合,通过几何缩放、双腔耦合和聚焦波边界测试进行校准,以模拟OWC性能。在抛物线聚焦下,双峰共振产生的峰值功率吸收是隔离装置的17倍,背风射孔设计将单室捕获比提高到基线的25倍。双腔室结构加上一个半圆形腔室,进一步提高了总吸收能量,并拓宽了有效带宽。这项工作为在聚焦波环境中工作的高效波能装置提供了实用的设计指导。
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引用次数: 0
Reasoning-agent-driven process simulation, optimization, carbon accounting and decarbonization of distillation. 推理-代理驱动的过程模拟,优化,碳核算和蒸馏脱碳。
Pub Date : 2026-01-08 DOI: 10.1038/s44172-025-00583-3
Sihan Tan, Xiaochi Zhou, Hai Zhou, Zhimian Hao, Yihang Xie, Liwei Cao, Guofei Shen, Yunhu Gao, Qun Shen, Wei Wei

Distillation is the most energy-consuming unit operation of the chemical industry, however, its decarbonization strategy necessitates laborious manual process simulation, optimization and carbon emission accounting. Here we established a reasoning agent consisting of a large language model (LLM) and an extensive tool set to automate learning material collection, process simulation, optimization and carbon emission accounting of a representative methanol and ethanol distillation case study. Then the agent automatically constructed a heat pump-assisted distillation process to save energy. The impact of three energy supply scenarios on the carbon emissions of distillation, namely, coal, natural gas and renewables, was evaluated. Combining the heat pump-assisted process and renewables could substantially reduce the carbon emission by 98% compared with the coal-based traditional distillation process. This study explored using reasoning agents to automate carbon emission and decarbonization intervention quantification, and facilitated high-resolution carbon emission models of the industry.

精馏是化工行业最耗能的单元操作,其脱碳策略需要人工模拟、优化和碳排放核算。在这里,我们建立了一个推理代理,由一个大型语言模型(LLM)和一个广泛的工具集组成,用于自动化学习材料收集、过程模拟、优化和碳排放核算,以代表甲醇和乙醇蒸馏案例研究。然后,该药剂自动构建了热泵辅助蒸馏过程,以节省能源。评估了煤炭、天然气和可再生能源三种能源供应情景对蒸馏过程碳排放的影响。将热泵辅助工艺与可再生能源相结合,与以煤为基础的传统蒸馏工艺相比,可以大幅减少98%的碳排放。本研究探索利用推理智能体实现碳排放和脱碳干预量化自动化,为行业高分辨率碳排放模型的建立提供便利。
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引用次数: 0
Human-led truck platooning with lane-changing capability for more efficient logistics: a framework and implementation. 具有变道能力的人工驾驶卡车队列,以提高物流效率:框架和实施。
Pub Date : 2026-01-07 DOI: 10.1038/s44172-025-00578-0
Jia Hu, Yongwei Feng, Mingyue Lei, Yiming Zhang, Haoran Wang, Xianhong Zhang, Zhijun Fu, Jie Lai

Truck platooning promises to enhance the efficiency of logistics, but commercial operation is hampered by safety and economic concerns. Human-lead truck platooning can mitigate these challenges by leveraging a human driver's expertise. However, existing human-lead truck platooning is limited to longitudinal control and lacks the lane-changing capability, which restricts logistical efficiency. To address this, we build upon previous research to propose a human-lead truck platooning method with lane-changing capability. The platoon leader is controlled by a skilled human driver, who is responsible for leading the following automated trucks. The human-lead platoon is enabled to cruise, lane-change, and obstacle avoidance, leveraging the driver's expertise to mitigate safety risks in long-tail scenarios. Drivers of the following trucks are not needed, reducing labor costs. The proposed method has been implemented in commercial operations at the world's largest port, Shanghai Yangshan Port, achieving an annual transport volume of 200,000 Twenty-foot Equivalent Units. It highlights a route for large-scale truck platooning implementation, potentially reshaping freight-transport operations.

卡车车队有望提高物流效率,但商业运营受到安全和经济问题的阻碍。通过利用人类驾驶员的专业知识,人类领导的卡车队列可以缓解这些挑战。然而,现有的人工引导卡车队列仅限于纵向控制,缺乏变道能力,限制了物流效率。为了解决这个问题,我们在先前研究的基础上提出了一种具有变道能力的人类引导卡车队列方法。排长由一名熟练的人类司机控制,他负责领导下面的自动卡车。人类领导的车队能够巡航、变道和避障,利用驾驶员的专业知识来降低长尾场景中的安全风险。不需要以下卡车的司机,降低了人工成本。该方法已在世界最大港口上海洋山港的商业运营中实施,年运输量达到20万20英尺当量单位。它为大规模卡车车队的实施提供了一条途径,可能会重塑货运业务。
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引用次数: 0
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Communications engineering
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