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Multi-band ultrathin reflective metasurface for linear and circular polarization conversion in Ku, K, and Ka bands 用于 Ku、K 和 Ka 波段线性和圆极化转换的多波段超薄反射元表面
Pub Date : 2024-09-09 DOI: 10.1038/s44172-024-00266-5
Humayun Zubair Khan, Abdul Jabbar, Jalil ur Rehman Kazim, Masood Ur Rehman, Muhammad Ali Imran, Qammer H. Abbasi
Linear polarization (LP) and circular polarization (CP) holds paramount importance in Ku, K, and Ka bands for satellite based communication, and remote sensing applications. Satellite based remote sensing applications face challenges like atmospheric attenuation, noise & interference, and signal degradation. Moreover, satellite based communication application demands CP in two distinct, non-adjacent frequency bands with orthogonal polarizations at greater oblique angles, considering the unpredictable incidence angles of electromagnetic (EM) waves. Addressing these challenges, an innovative metasurface polarization converter is proposed to operate efficiently across the Ku-band (13.5–18.0 GHz), K-band (18.0–26.5 GHz), and Ka-band (26.5–38.5 GHz) frequency ranges. The converter achieves left-handed circular polarization (LHCP) in the Ku- and Ka-bands within the frequency ranges of 14.57–15.65 GHz and 27.47–33.85 GHz for y-polarized incident EM waves. Additionally, it provides right-handed circular polarization (RHCP) in the K- and Ka-bands at 17.27–23.92 GHz and 35.87–38.32 GHz for y-polarized incident EM waves. The LP conversion ratio exceeds 95% in the frequency bands of 15.97–16.85 GHz, 24.70–26.65 GHz, and 34.37–35.45 GHz for y-polarized, LHCP, and RHCP incident EM waves, respectively. The metasurface exhibits robust performance up to incidence angles of 45 degrees under oblique conditions. Experimental validation using traditional board-circuit manufacturing demonstrates close agreement between measured co- and cross-polarized reflection coefficients and simulations in the 13.5–18 GHz, and 24–38.5 GHz frequency range. Thin metasurface with a thickness of only 0.64 = 0.013λo mm, the proposed design outperforms existing studies in the literature, establishing its competitive edge in terms of structure and performance. Humayun Zubair Khan and colleagues design a thin and efficient metasurface for polarisation conversion. Their solution can operate to up to 45-degree incidence angles and is suitable for satellite communications which use separated frequency bands with orthogonal circularly polarised waves.
线性极化(LP)和圆极化(CP)在 Ku、K 和 Ka 波段的卫星通信和遥感应用中至关重要。卫星遥感应用面临着大气衰减、噪声放大器、干扰和信号衰减等挑战。此外,考虑到电磁波(EM)的入射角难以预测,卫星通信应用需要在两个不同的、不相邻的频段上以更大的斜角进行正交极化。为应对这些挑战,我们提出了一种创新的元表面极化转换器,可在 Ku 波段(13.5-18.0 GHz)、K 波段(18.0-26.5 GHz)和 Ka 波段(26.5-38.5 GHz)频率范围内高效运行。该转换器可在 14.57-15.65 GHz 和 27.47-33.85 GHz 频率范围内的 Ku 波段和 Ka 波段实现左手圆极化(LHCP),适用于 y 极化入射电磁波。此外,它还能在 K 波段和 Ka 波段的 17.27-23.92 千兆赫和 35.87-38.32 千兆赫频率范围内为 Y 偏振入射电磁波提供右旋圆极化(RHCP)。在 15.97-16.85 GHz、24.70-26.65 GHz 和 34.37-35.45 GHz 频段,对于 y 偏振、LHCP 和 RHCP 入射电磁波,LP 转换率分别超过 95%。该元表面在入射角为 45 度的倾斜条件下表现出稳定的性能。使用传统电路板制造工艺进行的实验验证表明,在 13.5-18 GHz 和 24-38.5 GHz 频率范围内,测量的同极化和跨极化反射系数与模拟结果非常接近。薄元表面的厚度仅为 0.64 = 0.013λo 毫米,所提出的设计优于文献中的现有研究,从而确立了其在结构和性能方面的竞争优势。Humayun Zubair Khan 及其同事设计了一种用于极化转换的薄而高效的元表面。他们的解决方案入射角可达 45 度,适用于使用正交圆极化波分离频带的卫星通信。
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引用次数: 0
Building-block-flow computational model for large-eddy simulation of external aerodynamic applications 用于外部空气动力应用大涡流模拟的积木流计算模型
Pub Date : 2024-09-07 DOI: 10.1038/s44172-024-00278-1
Gonzalo Arranz, Yuenong Ling, Sam Costa, Konrad Goc, Adrián Lozano-Durán
Computational fluid dynamics is an essential tool for accelerating the discovery and adoption of transformative designs across multiple engineering disciplines. Despite its many successes, no single approach consistently achieves high accuracy for all flow phenomena of interest, primarily due to limitations in the modeling assumptions. Here, we introduce a closure model for wall-modeled large-eddy simulation to address this challenge. The model, referred to as the Building-block Flow Model (BFM), rests on the premise that a finite collection of simple flows encapsulates the essential missing physics necessary to predict more complex scenarios. The BFM is designed to: (1) predict multiple flow regimes, (2) unify the closure model at solid boundaries and the rest of the flow, (3) ensure consistency with numerical schemes and gridding strategies by accounting for numerical errors, (4) be directly applicable to arbitrary complex geometries, and (5) be scalable to model additional flow physics in the future. The BFM is utilized to predict key quantities in five cases, including an aircraft in landing configuration, demonstrating similar or superior capabilities compared to previous state-of-the-art models. The design of BFM opens up new opportunities for developing closure models that can accurately represent various flow physics across different scenarios. Arranz and colleagues introduce a closure model for computational fluid dynamics. Their approach is implemented using artificial neural networks. It predicts multiple flow conditions, is directly applicable to complex geometries, and ensures consistency with numerical schemes.
计算流体动力学是加速发现和采用跨多个工程学科的变革性设计的重要工具。尽管计算流体动力学取得了许多成功,但没有一种方法能始终如一地为所有相关流动现象实现高精度,这主要是由于建模假设的局限性。在此,我们介绍一种用于壁面建模大涡流模拟的闭合模型,以应对这一挑战。该模型被称为 "积木式流动模型"(BFM),其前提是有限的简单流动集合囊括了预测更复杂情况所需的基本缺失物理量。积木式水流模型旨在(1) 预测多种流动状态,(2) 统一固体边界的封闭模型和流动的其他部分,(3) 通过考虑数值误差确保与数值方案和网格策略的一致性,(4) 直接适用于任意复杂几何形状,(5) 具有可扩展性,以便在未来模拟更多的流动物理。BFM 可用于预测五种情况下的关键量,包括飞机着陆构型,与以前的先进模型相比,BFM 具有类似或更优越的能力。BFM 的设计为开发闭合模型提供了新的机遇,这些模型可以准确地表示不同情况下的各种流动物理特性。Arranz 及其同事介绍了计算流体力学的闭合模型。他们的方法是利用人工神经网络实现的。该模型可预测多种流动条件,直接适用于复杂的几何形状,并确保与数值方案的一致性。
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引用次数: 0
An experimental system for detection and localization of hemorrhage using ultra-wideband microwaves with deep learning 利用超宽带微波和深度学习检测和定位出血的实验系统
Pub Date : 2024-09-05 DOI: 10.1038/s44172-024-00259-4
Eisa Hedayati, Fatemeh Safari, George Verghese, Vito R. Ciancia, Daniel K. Sodickson, Seena Dehkharghani, Leeor Alon
Stroke is a leading cause of mortality and disability. Emergent diagnosis and intervention are critical, and predicated upon initial brain imaging; however, existing clinical imaging modalities are generally costly, immobile, and demand highly specialized operation and interpretation. Low-energy microwaves have been explored as a low-cost, small form factor, fast, and safe probe for tissue dielectric properties measurements, with both imaging and diagnostic potential. Nevertheless, challenges inherent to microwave reconstruction have impeded progress, hence conduction of microwave imaging remains an elusive scientific aim. Herein, we introduce a dedicated experimental framework comprising a robotic navigation system to translate blood-mimicking phantoms within a human head model. An 8-element ultra-wideband array of modified antipodal Vivaldi antennas was developed and driven by a two-port vector network analyzer spanning 0.6–9.0 GHz at an operating power of 1 mW. Complex scattering parameters were measured, and dielectric signatures of hemorrhage were learned using a dedicated deep neural network for prediction of hemorrhage classes and localization. An overall sensitivity and specificity for detection >0.99 was observed, with Rayleigh mean localization error of 1.65 mm. The study establishes the feasibility of a robust experimental model and deep learning solution for ultra-wideband microwave stroke detection. Eisa Hedayati, Fatemeh Safari and colleagues use an array of ultra-wideband microwave antennas to locate the haemorrhages in a human head phantom. The results of the measurements are processed by the deep neural network algorithm to classify the digital signatures for efficient detection and localization.
脑卒中是导致死亡和残疾的主要原因。紧急诊断和干预至关重要,并以初步脑成像为基础;然而,现有的临床成像模式通常成本高昂、无法移动,并且需要高度专业化的操作和解释。低能量微波作为一种低成本、小尺寸、快速和安全的探针,已被用于组织介电特性测量,具有成像和诊断潜力。然而,微波重建所固有的挑战阻碍了研究的进展,因此微波成像仍然是一个难以实现的科学目标。在本文中,我们介绍了一个专用的实验框架,该框架由一个机器人导航系统组成,用于在人体头部模型中转换仿血模型。我们开发了一个 8 元超宽带阵列,该阵列由改进的反脚维瓦尔第天线组成,并由双端口矢量网络分析仪驱动,工作功率为 1 mW,频率跨度为 0.6-9.0 GHz。测量了复杂的散射参数,并使用专用的深度神经网络学习了出血的介电特征,以预测出血类别和定位。总体检测灵敏度和特异性均为 0.99,瑞利平均定位误差为 1.65 毫米。该研究证明了超宽带微波中风检测的稳健实验模型和深度学习解决方案的可行性。Eisa Hedayati、Fatemeh Safari 及其同事使用超宽带微波天线阵列定位人体头部模型中的出血点。测量结果经过深度神经网络算法处理,对数字签名进行分类,从而实现高效检测和定位。
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引用次数: 0
Localization and recognition of human action in 3D using transformers 使用变压器定位和识别三维人体动作。
Pub Date : 2024-09-03 DOI: 10.1038/s44172-024-00272-7
Jiankai Sun, Linjiang Huang, Hongsong Wang, Chuanyang Zheng, Jianing Qiu, Md Tauhidul Islam, Enze Xie, Bolei Zhou, Lei Xing, Arjun Chandrasekaran, Michael J. Black
Understanding a person’s behavior from their 3D motion sequence is a fundamental problem in computer vision with many applications. An important component of this problem is 3D action localization, which involves recognizing what actions a person is performing, and when the actions occur in the sequence. To promote the progress of the 3D action localization community, we introduce a new, challenging, and more complex benchmark dataset, BABEL-TAL (BT), for 3D action localization. Important baselines and evaluating metrics, as well as human evaluations, are carefully established on this benchmark. We also propose a strong baseline model, i.e., Localizing Actions with Transformers (LocATe), that jointly localizes and recognizes actions in a 3D sequence. The proposed LocATe shows superior performance on BABEL-TAL as well as on the large-scale PKU-MMD dataset, achieving state-of-the-art performance by using only 10% of the labeled training data. Our research could advance the development of more accurate and efficient systems for human behavior analysis, with potential applications in areas such as human-computer interaction and healthcare. Jiankai Sun, Michael J. Black and colleagues present a benchmark for human movement analysis. Their transformer-based approach, LocATe, learns to perform both temporal action localization and recognition.
从一个人的三维运动序列中了解其行为是计算机视觉中的一个基本问题,应用广泛。这个问题的一个重要组成部分是三维动作定位,它涉及识别一个人正在做什么动作,以及这些动作在序列中出现的时间。为了促进三维动作定位领域的进步,我们为三维动作定位引入了一个全新的、具有挑战性的、更复杂的基准数据集 BABEL-TAL (BT)。我们在此基准上精心建立了重要的基准和评估指标,并进行了人工评估。我们还提出了一个强大的基线模型,即用变换器定位动作(LocATe),它能在三维序列中联合定位和识别动作。所提出的 LocATe 在 BABEL-TAL 和大规模 PKU-MMD 数据集上都表现出了卓越的性能,仅使用了 10% 的标注训练数据就达到了最先进的性能。我们的研究可以推动更准确、更高效的人类行为分析系统的开发,并有望应用于人机交互和医疗保健等领域。
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引用次数: 0
Multidisciplinary approaches in electronic nicotine delivery systems pulmonary toxicology: emergence of living and non-living bioinspired engineered systems 电子尼古丁输送系统肺毒理学的多学科方法:生物和非生物生物启发工程系统的出现。
Pub Date : 2024-09-03 DOI: 10.1038/s44172-024-00276-3
Kambez H. Benam
Technology-based platforms offer crucial support for regulatory agencies in overseeing tobacco products to enhance public health protection. The use of electronic nicotine delivery systems (ENDS), such as electronic cigarettes, has surged exponentially over the past decade. However, the understanding of the impact of ENDS on lung health remains incomplete due to scarcity of physiologically relevant technologies for evaluating their toxicity. This review examines the societal and public health impacts of ENDS, prevalent preclinical approaches in pulmonary space, and the application of emerging Organ-on-Chip technologies and bioinspired robotics for assessing ENDS respiratory toxicity. It highlights challenges in ENDS inhalation toxicology and the value of multidisciplinary bioengineering approaches for generating reliable, human-relevant regulatory data at an accelerated pace. Kambez Benam reviews preclinical approaches to assess lung health impacts of e-cigarettes, highlighting limitations of current strategies in capturing 3D lung architecture and inhalation mechanics. The review article emphasizes the promise of Organs-on-Chips and Bioinspired Robotics.
基于技术的平台为监管机构监督烟草产品以加强公众健康保护提供了重要支持。过去十年来,电子尼古丁输送系统(ENDS)(如电子香烟)的使用量激增。然而,由于缺乏评估其毒性的生理学相关技术,人们对 ENDS 对肺部健康的影响的了解仍不全面。这篇综述探讨了 ENDS 对社会和公共健康的影响、肺部空间流行的临床前方法,以及新兴芯片器官技术和生物启发机器人技术在评估 ENDS 呼吸系统毒性方面的应用。报告强调了ENDS吸入毒理学面临的挑战,以及多学科生物工程方法在加速生成可靠、与人类相关的监管数据方面的价值。
{"title":"Multidisciplinary approaches in electronic nicotine delivery systems pulmonary toxicology: emergence of living and non-living bioinspired engineered systems","authors":"Kambez H. Benam","doi":"10.1038/s44172-024-00276-3","DOIUrl":"10.1038/s44172-024-00276-3","url":null,"abstract":"Technology-based platforms offer crucial support for regulatory agencies in overseeing tobacco products to enhance public health protection. The use of electronic nicotine delivery systems (ENDS), such as electronic cigarettes, has surged exponentially over the past decade. However, the understanding of the impact of ENDS on lung health remains incomplete due to scarcity of physiologically relevant technologies for evaluating their toxicity. This review examines the societal and public health impacts of ENDS, prevalent preclinical approaches in pulmonary space, and the application of emerging Organ-on-Chip technologies and bioinspired robotics for assessing ENDS respiratory toxicity. It highlights challenges in ENDS inhalation toxicology and the value of multidisciplinary bioengineering approaches for generating reliable, human-relevant regulatory data at an accelerated pace. Kambez Benam reviews preclinical approaches to assess lung health impacts of e-cigarettes, highlighting limitations of current strategies in capturing 3D lung architecture and inhalation mechanics. The review article emphasizes the promise of Organs-on-Chips and Bioinspired Robotics.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large area kidney imaging for pre-transplant evaluation using real-time robotic optical coherence tomography 使用实时机器人光学相干断层扫描进行移植前评估的大面积肾脏成像。
Pub Date : 2024-09-02 DOI: 10.1038/s44172-024-00264-7
Xihan Ma, Mousa Moradi, Xiaoyu Ma, Qinggong Tang, Moshe Levi, Yu Chen, Haichong K. Zhang
Optical coherence tomography (OCT) can be used to image microstructures of human kidneys. However, current OCT probes exhibit inadequate field-of-view, leading to potentially biased kidney assessment. Here we present a robotic OCT system where the probe is integrated to a robot manipulator, enabling wider area (covers an area of 106.39 mm by 37.70 mm) spatially-resolved imaging. Our system comprehensively scans the kidney surface at the optimal altitude with preoperative path planning and OCT image-based feedback control scheme. It further parameterizes and visualizes microstructures of large area. We verified the system positioning accuracy on a phantom as 0.0762 ± 0.0727 mm and showed the clinical feasibility by scanning ex vivo kidneys. The parameterization reveals vasculatures beneath the kidney surface. Quantification on the proximal convoluted tubule of a human kidney yields clinical-relevant information. The system promises to assess kidney viability for transplantation after collecting a vast amount of whole-organ parameterization and patient outcomes data. Xihan Ma and colleagues expand the field-of-view for optical coherence tomography using a robotic manipulator to control the probe. They achieve high position precision in ex vivo demonstration.
光学相干断层扫描(OCT)可用于成像人体肾脏的微观结构。然而,目前的 OCT 探头视场不足,导致对肾脏的评估可能存在偏差。在这里,我们展示了一种机器人 OCT 系统,该系统将探头集成到机器人操纵器上,实现了更大面积(覆盖面积 106.39 毫米 x 37.70 毫米)的空间分辨成像。我们的系统通过术前路径规划和基于 OCT 图像的反馈控制方案,以最佳高度全面扫描肾脏表面。它还能进一步参数化和可视化大面积的微观结构。我们在模型上验证了系统的定位精度为 0.0762 ± 0.0727 毫米,并通过扫描体外肾脏证明了其临床可行性。参数化显示了肾脏表面下的血管。对人体肾脏近端曲小管的定量分析产生了与临床相关的信息。该系统有望在收集大量全器官参数化数据和患者预后数据后,评估肾脏在移植手术中的存活能力。
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引用次数: 0
Achieving precise multiparameter measurements with distributed optical fiber sensor using wavelength diversity and deep neural networks 利用波长分集和深度神经网络实现分布式光纤传感器的多参数精确测量
Pub Date : 2024-08-31 DOI: 10.1038/s44172-024-00274-5
Nageswara Lalam, Sandeep Bukka, Hari Bhatta, Michael Buric, Paul Ohodnicki, Ruishu Wright
The development of advanced distributed optical fiber sensing systems that are capable of performing accurate and spatially resolved multiparameter measurements is of great interest to a wide range of scientific and industrial applications. Here, we propose and experimentally demonstrate a wavelength diversity based advanced distributed optical fiber sensor system to accomplish multiparameter sensing while greatly enhancing measurement accuracy. A suite of deep neural network (DNN) algorithms are developed and verified for data denoising, rapid Brillouin frequency shift estimation, and vibration data event classification. As a proof-of-concept, we demonstrate the effectiveness of the proposed advanced wavelength diversity distributed fiber sensor system assisted by DNN for simultaneous, independent measurements of static strain, temperature, and acoustic vibrations over a 25 km long sensing fiber at 3 m spatial resolution. These results suggest the potential for an intelligent multiparameter monitoring system with enhanced performance in advanced structural health monitoring applications. Nageswara Lalam and colleagues demonstrate a multiparameter distributed optical fibre sensing. They employ the wavelength multiplexing technique in Brillouin and Rayleigh scattering with the deep neural networks and achieve an improved performance of strain, temperature and vibration detection.
先进的分布式光纤传感系统能够进行精确的空间分辨多参数测量,其开发对广泛的科学和工业应用具有重大意义。在此,我们提出并通过实验演示了一种基于波长分集的先进分布式光纤传感系统,该系统可实现多参数传感,同时大大提高测量精度。我们开发并验证了一套深度神经网络(DNN)算法,用于数据去噪、快速布里渊频移估计和振动数据事件分类。作为概念验证,我们展示了拟议的先进波长分集分布式光纤传感器系统在 DNN 辅助下,以 3 米的空间分辨率在 25 千米长的传感光纤上同时独立测量静态应变、温度和声学振动的有效性。这些结果表明,在先进的结构健康监测应用中,智能多参数监测系统具有提高性能的潜力。Nageswara Lalam 及其同事展示了多参数分布式光纤传感。他们将布里渊和瑞利散射中的波长复用技术与深度神经网络相结合,提高了应变、温度和振动检测的性能。
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引用次数: 0
Computer numerical control knitting of high-resolution mosquito bite blocking textiles 电脑数控编织高分辨率蚊虫叮咬阻断纺织品。
Pub Date : 2024-08-27 DOI: 10.1038/s44172-024-00268-3
Bryan Holt, Kyle Oswalt, Alexa England, Richard Murphy, Isabella Owens, Micaela Finney, Natalie Wong, Sushil Adhikari, James McCann, John Beckmann
Mosquitoes and other biting arthropods transmit diseases worldwide, causing over 700,000 deaths each year, and costing about 3 billion USD annually for Aedes species alone. Insect vectored diseases also pose a considerable threat to agricultural animals. While clothing could provide a simple solution to vector-borne diseases, modern textiles do not effectively block mosquito bites. Here we have designed three micro-resolution knitted structures, with five adjustable parameters that can block mosquito bites. These designs, which exhibit significant bite reduction were integrated into a computer numerical control knitting robot for mass production of bite-blocking garments with minimal human labor. We then quantified the comfort of blocking garments. Our knits enable individuals to protect themselves from insects amidst their day-to-day activities without impacting the environment. Bryan Holt, Kyle Oswalt and colleagues design the mosquito bite-proof knitting pattern. Their approach can be implemented in programmable knitting robots for mass production.
蚊子和其他叮咬性节肢动物在全球传播疾病,每年造成 70 多万人死亡,仅伊蚊一项每年就造成约 30 亿美元的损失。昆虫传播的疾病也对农业动物构成相当大的威胁。虽然衣物可以为病媒传播疾病提供简单的解决方案,但现代纺织品并不能有效阻挡蚊虫叮咬。在这里,我们设计了三种微分辨率针织结构,具有五个可调参数,可以阻挡蚊虫叮咬。我们将这些能显著减少蚊虫叮咬的设计集成到电脑数控针织机器人中,以最少的人力批量生产阻挡蚊虫叮咬的服装。然后,我们对挡蚊衣的舒适度进行了量化。我们的针织品能让人们在日常活动中保护自己免受昆虫叮咬,同时又不会对环境造成影响。
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引用次数: 0
Low frequency ultrasound elicits broad cortical responses inhibited by ketamine in mice 低频超声在小鼠大脑皮层引起的广泛反应受到氯胺酮的抑制。
Pub Date : 2024-08-27 DOI: 10.1038/s44172-024-00269-2
Linli Shi, Christina Mastracchio, Ilyas Saytashev, Meijun Ye
The neuromodulatory effects of >250 kHz ultrasound have been well-demonstrated, but the impact of lower-frequency ultrasound, which can transmit better through air and the skull, on the brain is unclear. This study investigates the biological impact of 40 kHz pulsed ultrasound on the brain using calcium imaging and electrophysiology in mice. Our findings reveal burst duration-dependent neural responses in somatosensory and auditory cortices, resembling responses to 12 kHz audible tone, in vivo. In vitro brain slice experiments show no neural responses to 300 kPa 40 kHz ultrasound, implying indirect network effects. Ketamine fully blocks neural responses to ultrasound in both cortices but only partially affects 12 kHz audible tone responses in the somatosensory cortex and has no impact on auditory cortex 12 kHz responses. This suggests that low-frequency ultrasound’s cortical effects rely heavily on NMDA receptors and may involve mechanisms beyond indirect auditory cortex activation. This research uncovers potential low-frequency ultrasound effects and mechanisms in the brain, offering a path for future neuromodulation. Dr Ye and colleagues investigate the biological impact low-frequency ultrasound pulses can have on the cortex of mice. They observe pulse duration dependent neural responses and find that ketamine can block parameter-dependent brain responses at certain frequencies.
频率大于 250 千赫的超声波对神经的调节作用已得到充分证实,但频率较低的超声波能更好地穿过空气和头骨,其对大脑的影响尚不清楚。本研究利用钙成像和小鼠电生理学研究了 40 千赫脉冲超声对大脑的生物影响。我们的研究结果表明,在躯体感觉皮层和听觉皮层中,爆发持续时间依赖性神经反应与体内 12 千赫可听音调的反应相似。体外脑片实验显示,300 kPa 40 kHz 超声波不会引起神经反应,这意味着存在间接网络效应。氯胺酮能完全阻断两个皮层对超声波的神经反应,但只能部分影响躯体感觉皮层对 12 kHz 可听音的反应,对听觉皮层的 12 kHz 反应没有影响。这表明,低频超声对大脑皮层的影响主要依赖于 NMDA 受体,可能涉及间接激活听觉皮层以外的机制。这项研究揭示了低频超声在大脑中的潜在效应和机制,为未来的神经调控提供了一条途径。
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引用次数: 0
Manifold-based approach for neural network robustness analysis 基于 Manifold 的神经网络鲁棒性分析方法
Pub Date : 2024-08-24 DOI: 10.1038/s44172-024-00263-8
Ali Sekmen, Bahadir Bilgin
It is important to understand the mathematical foundations of neural networks and to include robustness in model evaluation. Here, we introduce algorithms based on manifold curvature estimation to assess neural network robustness. These algorithms rely solely on training data and do not require regular or adversarial test data. Initially, a metric is proposed to measure the curvature of discrete data manifolds by introducing weighted angles concept between subspaces. Following this, a robustness measure is introduced that is independent of network architecture or model parameters. Lastly, two additional methods are introduced, utilizing curvature estimation of special manifolds formed by using gradient vectors between output and input network layers, alongside manifold curvature estimation. A comprehensive evaluation is provided on multiple network models using the CIFAR-10 dataset. Manifold geometry-based robustness analysis may lead to the development of not only accurate but also robust neural network models. Bahadir Bilgin and Ali Sekmen build the framework for examining the post-training robustness of the neural network. Their method estimates the data curvature on the output layer and does not require knowledge of the black-box topology.
了解神经网络的数学基础并将鲁棒性纳入模型评估非常重要。在此,我们介绍基于流形曲率估计的算法,用于评估神经网络的鲁棒性。这些算法仅依赖于训练数据,不需要常规或对抗性测试数据。首先,通过引入子空间之间的加权角度概念,提出了一种度量离散数据流形曲率的方法。随后,引入了一种与网络架构或模型参数无关的鲁棒性测量方法。最后,除了流形曲率估算外,还介绍了另外两种方法,即利用输出和输入网络层之间的梯度向量形成的特殊流形的曲率估算。利用 CIFAR-10 数据集对多个网络模型进行了综合评估。基于流形几何的鲁棒性分析不仅能开发出准确的神经网络模型,还能开发出鲁棒性神经网络模型。Bahadir Bilgin 和 Ali Sekmen 建立了检查神经网络训练后鲁棒性的框架。他们的方法可以估计输出层的数据曲率,而且不需要黑盒拓扑知识。
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引用次数: 0
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Communications engineering
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