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Computational modelling of hollow fibre haemodialysers: current status and future directions. 中空纤维血液透析器的计算模型:现状与未来方向。
Pub Date : 2025-11-20 DOI: 10.1038/s44172-025-00526-y
Ruhit Sinha, Anne E Staples

Current in silico dialyser models remain accurate only under narrowly constrained conditions. Advances in computing power and increasing levels of interdisciplinary collaboration, however, now set the stage for more robust computational haemodialyser models. In this review, we survey existing modelling approaches-long used to guide haemodialyser design and clinical nephrology practice-identify key unresolved challenges, and propose computational strategies poised to accelerate the development of dialyser technologies that better meet the needs of kidney failure patients.

目前的硅透析器模型仅在狭窄的约束条件下保持准确。然而,计算能力的进步和跨学科合作水平的提高,现在为更强大的计算血液透析模型奠定了基础。在这篇综述中,我们调查了现有的建模方法——长期用于指导血液透析设计和临床肾脏病实践——确定了关键的未解决的挑战,并提出了计算策略,以加速透析技术的发展,更好地满足肾衰竭患者的需求。
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引用次数: 0
Degrees of uncertainty: conformal deep learning for non-invasive core body temperature prediction in extreme environments. 不确定度:适形深度学习在极端环境下的无创核心体温预测。
Pub Date : 2025-11-20 DOI: 10.1038/s44172-025-00548-6
Joel Strickland, Marco Ghisoni, Hannah Marshall, Thomas Whitehead, Bogdan Nenchev, Ben Pellegrini, Charles Phillips, Karl Tassenberg, Sarah Davey, Sandra Dorman, Joseph Sol, David Ferguson, Gareth Conduit

Accurate estimation of core body temperature (CBT) is essential for physiological monitoring, yet current non-invasive methods lack statistically calibrated uncertainty estimates required for safety-critical use. Here we introduce a conformal deep learning framework for real-time, non-invasive CBT prediction with calibrated uncertainty, demonstrated in high-risk heat-stress environments. Developed from over 140,000 physiological measurements across six operational domains, the model achieves a test error of 0.29 °C, outperforming the widely used ECTemp™ algorithm with a 12-fold improvement in calibrated probabilistic accuracy and statistically valid prediction intervals. Designed for integration with wearable devices, the system uses accessible physiological, demographic, and environmental inputs to support practical, confidence-informed monitoring. A customizable alert engine enables proactive safety interventions based on user-defined thresholds and model confidence. By combining deep learning with conformal prediction, this approach establishes a generalizable foundation for trustworthy, non-invasive physiological monitoring, demonstrated here for CBT under heat stress but applicable to broader safety-critical settings.

准确估计核心体温(CBT)对于生理监测至关重要,但目前的非侵入性方法缺乏安全关键应用所需的统计校准不确定性估计。在这里,我们引入了一个适形深度学习框架,用于实时、无创的CBT预测,具有校准的不确定性,在高风险热应激环境中得到了验证。该模型从六个操作域的140,000多个生理测量数据中开发而来,测试误差为0.29°C,优于广泛使用的ECTemp™算法,校准概率精度和统计有效预测区间提高了12倍。该系统设计用于与可穿戴设备集成,使用可访问的生理、人口统计和环境输入来支持实用的、有信心的监测。可定制的警报引擎支持基于用户定义的阈值和模型置信度的主动安全干预。通过将深度学习与适形预测相结合,这种方法为可信赖的、无创的生理监测建立了一个可推广的基础,这里展示了热应激下的CBT,但适用于更广泛的安全关键环境。
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引用次数: 0
Huge transverse Maxwell stress in ferroelectric fluids and prototyping of new ferroelectric motors. 铁电流体中的巨大横向麦克斯韦应力及新型铁电马达的原型设计。
Pub Date : 2025-11-19 DOI: 10.1038/s44172-025-00530-2
Tatsuhiro Tsukamoto, Suzushi Nishimura

Electrostatic actuators typically rely on Maxwell stress, whereas the use of transverse electrostatic force (TEF) has been overlooked because of its weakness. The discovery of polar nematic liquid crystals in 2017 changed this, enabling lower operating voltages and high output power. We here explore TEF in a ferroelectric fluid and demonstrate a ferroelectric motor based on a new driving principle. Using ferroelectric nematic liquid crystals, we show that TEF can elevate the fluid between electrodes with a gap of 2.5 mm up to more than 80 mm at only 28 V mm-1, corresponding to a stress greater than 1000 N m-2. Polarization analysis also revealed a continuous paraelectric-to-ferroelectric transition. Unlike electromagnetic motors, ferroelectric motors require no metal rotors or magnets, resulting in a lower weight and simplified device structure and eliminating the need for rare-earth materials. These results suggest that ferroelectric fluids can enhance electrostatic actuator performance and practicability.

静电致动器通常依赖于麦克斯韦应力,而横向静电力(TEF)的使用由于其弱点而被忽视。2017年极性向列液晶的发现改变了这一点,实现了更低的工作电压和高输出功率。我们在此探索铁电流体中的TEF,并展示一种基于新驱动原理的铁电马达。利用铁电向列液晶,我们发现TEF可以在28 V mm-1的条件下将电极间隙为2.5 mm的流体提升到80 mm以上,对应于大于1000 N m-2的应力。极化分析也揭示了一个连续的准电到铁电的转变。与电磁电机不同,铁电电机不需要金属转子或磁铁,因此重量更轻,简化了设备结构,并且消除了对稀土材料的需求。这些结果表明,铁电流体可以提高静电执行器的性能和实用性。
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引用次数: 0
Dynamic hovering for uncrewed underwater vehicles via an error-separation-based cooperative strategy. 基于误差分离的无人潜航器动态悬停协同策略。
Pub Date : 2025-11-18 DOI: 10.1038/s44172-025-00528-w
Xiaoli Luan, Shenhan Yu, Haiying Wan, Fei Liu

Uncrewed underwater vehicles(UUVs) play an indispensable role in ocean resource efficiency utilization due to their security and cost-effectiveness. However, the significant uncertainties, time-varying disturbances, and unstructured subsea environments pose challenges for UUVs in achieving precise and efficient marine missions. To address these challenges, this study introduces a novel cooperative control framework for UUVs. The proposed framework minimizes the high control efforts of sliding mode control while preserving robustness, enabling efficiency and precision for long-duration dynamic hovering missions of UUVs. Specifically, a key innovation is the development of a deviation separation strategy, which, for the first time, decouples hovering deviations into task-specific and anti-disturbance components using an influence function. This enables real-time disturbance estimation without prior knowledge enabling adaptive disturbance compensation. By cooperating between LQR and SMC, the proposed method avoids the performance conflicts commonly observed in single-controller schemes. This structure improves compensation accuracy, robustness to disturbances, and energy efficiency across various operating conditions. The results demonstrate that the proposed cooperative control strategy effectively counters current perturbations by leveraging the real-time insights from the error segregation, while concurrently executing high-precision hovering tasks with low control costs. This work advances UUVs control, offering a versatile solution for complex underwater tasks.

无人潜航器以其安全性和经济性在海洋资源高效利用中发挥着不可或缺的作用。然而,巨大的不确定性、时变干扰和非结构化海底环境对uuv实现精确、高效的海上任务构成了挑战。为了解决这些挑战,本研究引入了一种新的uuv协同控制框架。该框架最大限度地减少了滑模控制的高控制工作量,同时保持了鲁棒性,使无人潜航器长时间动态悬停任务的效率和精度得以实现。具体来说,一个关键的创新是偏差分离策略的发展,该策略首次使用影响函数将悬停偏差解耦为特定任务和抗干扰组件。这使得实时干扰估计没有先验知识,使自适应干扰补偿。该方法通过LQR和SMC的协作,避免了单控制器方案中常见的性能冲突。这种结构提高了补偿精度,对干扰的鲁棒性,以及在各种操作条件下的能源效率。结果表明,所提出的协同控制策略利用误差分离的实时洞察,有效地对抗当前扰动,同时以较低的控制成本执行高精度悬停任务。这项工作推进了uuv控制,为复杂的水下任务提供了一个通用的解决方案。
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引用次数: 0
Wireless active feedback loop for backscattering communication. 后向散射通信无线有源反馈回路。
Pub Date : 2025-11-18 DOI: 10.1038/s44172-025-00529-9
Etienne Perret

The rise of the Internet of Things (IoT) is creating new communication needs that require us to completely rethink how we design wireless interaction between potentially diverse devices, which must be increasingly environmentally friendly and agile. This article introduces a wireless communication method elegantly grounded in the principle of the RF feedback loop. Unlike traditional communication methods, this approach does not require the reader to emit any waves in the absence of a transponder. Instead, communication occurs when a self-sustaining wave spontaneously emerges as the transponder enters the reader's reading zone, forming an active feedback loop between the two devices. This novel method of transmitting RF signals creates a new paradigm in the communications field that will significantly influence modes of interaction, especially in the IoT. This method significantly decreases the emission of unnecessary RF waves and ensures complete discretion for the reader when no transponder is within range. The principle of Wireless Active Feedback Loop Communication (WAFLC) has been validated through both simulations and practical tests, showing a strong correlation between the two.

物联网(IoT)的兴起正在创造新的通信需求,这要求我们彻底重新思考如何设计潜在不同设备之间的无线交互,这必须越来越环保和灵活。本文介绍了一种基于射频反馈回路原理的优雅接地无线通信方法。与传统的通信方法不同,这种方法不需要阅读器在没有应答器的情况下发射任何波。相反,当应答器进入阅读器的阅读区时,一个自我维持的波自发出现,在两个设备之间形成一个主动反馈回路,通信就发生了。这种传输射频信号的新方法在通信领域创造了一个新的范例,将显著影响交互模式,特别是在物联网中。这种方法大大减少了不必要的射频波的发射,并确保了当没有应答器在范围内时,阅读器完全自由裁量权。无线有源反馈环路通信(WAFLC)的原理已经通过仿真和实际测试得到验证,两者之间存在很强的相关性。
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引用次数: 0
Cascaded guidance, state estimation, and control for depth tracking of underactuated autonomous underwater vehicles. 欠驱动自主水下航行器的级联制导、状态估计和深度跟踪控制。
Pub Date : 2025-11-14 DOI: 10.1038/s44172-025-00521-3
Yang Qu, Qin Zhang, Xianbo Xiang, Shaolong Yang, Lilong Cai

Cascaded guidance, state estimation, and control systems have been successfully implemented in autonomous underwater vehicles. However, disordered convergence sequences among subsystems fundamentally induce system oscillations and instabilities. Here, we introduce a temporal-sequencing-convergent cascaded guidance, state estimation, and control system for depth-tracking of underactuated autonomous underwater vehicles. It establishes an ordered convergence architecture: state estimation converges first with a planning window td, followed by control execution with a planning time window tc, and guidance finally converges with a planning time window tf, adhering to a temporal-sequencing-convergent criterion td < tc < tf. This architecture, validated through experiments, ensures stable and efficient depth-tracking performance owing to well-ordered convergence of subsystems. Conversely, experiments violating the temporal-sequencing-convergent criterion exhibited prominent oscillatory depth-tracking responses. Our method outperformed selected approaches, achieving a lower average depth-tracking error of 1.32 cm under sudden external disturbances. Notably, even with prominent pitch-tracking errors using a PD controller, our proposed guidance design also showcased remarkable attack-angle compensation capability, thereby maintaining precise depth-tracking performance.

级联制导、状态估计和控制系统已经在自主水下航行器中成功实现。然而,子系统之间的无序收敛序列从根本上导致了系统的振荡和不稳定。本文介绍了一种用于欠驱动自主水下航行器深度跟踪的时间序列收敛级联制导、状态估计和控制系统。建立了一种有序收敛体系结构:状态估计先用规划窗口td收敛,控制执行再用规划时间窗口tc收敛,引导最终用规划时间窗口tf收敛,并遵循时序收敛准则td < tc < tf。通过实验验证,该体系结构由于子系统的有序收敛,保证了稳定高效的深度跟踪性能。相反,违反时间序列收敛准则的实验表现出明显的振荡深度跟踪响应。我们的方法优于选择的方法,在突发外部干扰下实现了较低的平均深度跟踪误差1.32 cm。值得注意的是,即使使用PD控制器存在明显的俯仰跟踪误差,我们提出的制导设计也显示出出色的攻角补偿能力,从而保持精确的深度跟踪性能。
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引用次数: 0
MXene alloy-based metal-semiconductor contact for low-resistive field-effect transistors. 用于低阻场效应晶体管的MXene合金金属半导体触点。
Pub Date : 2025-11-13 DOI: 10.1038/s44172-025-00522-2
Saheb Bera, Deepanshu Kaushik, Hemant Kumar

MXenes offer a unique platform for designing high-performance electronic devices due to their diverse properties and chemical tunability. This study focuses on engineering low-resistance metal-semiconductor contacts using MXenes for future field-effect transistor applications. Through a comprehensive approach combining first-principles calculations, transport simulations, and alloy phase engineering, we demonstrate the feasibility of achieving low-resistance contacts with high current-carrying capacity. Through first-principles calculations, we identify promising MXene heterojunctions based on lattice matching and Schottky barrier height. Notably, the Ta2CO2-Ti2CO2 contact exhibits a remarkably low Schottky barrier height. Using non-equilibrium Green's function calculations, we demonstrate high output current in this contact, indicating low resistance. Further analysis reveals the critical role of carrier density and detrimental impact of metal-induced gap states. To suppress metal-induced gap states, we propose an interfacial alloying strategy using a Ta2xTi2(1-x)CO2 solid solution, which reduces interfacial charge transfer and promotes smoother electronic coupling. This, in turn, reduces the Fermi-level pinning effect and contributes to a substantial reduction in contact resistance across the MXene interface. This study highlights the potential of MXenes as building blocks for advanced electronics and provides a pathway for engineering high-performance contacts through a combined computational and design approach.

MXenes由于其不同的特性和化学可调性,为设计高性能电子设备提供了一个独特的平台。本研究的重点是利用MXenes为未来的场效应晶体管应用设计低电阻金属半导体触点。通过结合第一性原理计算、输运模拟和合金相工程的综合方法,我们证明了实现具有高载流能力的低电阻触点的可行性。通过第一性原理计算,我们根据晶格匹配和肖特基势垒高度确定了有前途的MXene异质结。值得注意的是,Ta2CO2-Ti2CO2接触表现出非常低的肖特基势垒高度。使用非平衡格林函数计算,我们证明了该触点的高输出电流,表明低电阻。进一步分析揭示了载流子密度的关键作用和金属诱导的间隙态的不利影响。为了抑制金属诱导的间隙状态,我们提出了一种使用Ta2xTi2(1-x)CO2固溶体的界面合金化策略,该策略可以减少界面电荷转移并促进更平滑的电子耦合。这反过来又降低了费米能级的钉住效应,并有助于大幅度降低MXene界面上的接触电阻。这项研究强调了MXenes作为先进电子元件构建模块的潜力,并通过结合计算和设计方法为工程高性能触点提供了途径。
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引用次数: 0
MXene electrochemical phosphate sensors. MXene电化学磷酸盐传感器。
Pub Date : 2025-11-12 DOI: 10.1038/s44172-025-00519-x
Thiba Nagaraja, Anupma Thakur, Andrey Krayev, A Edward Robinson, Aleksandra Vojvodic, Babak Anasori, Suprem R Das

Rapid and accurate detection of molecular species with a high degree of selectivity and sensitivity constitutes the ultimate goal of designing sensors for various applications, from studying nutrients in soil-water systems to assessing physiological conditions in human health. With recent progress, two-dimensional (2D) transition metal carbides/nitrides have shown great potential for applications such as energy storage and electromagnetic interference shielding. However, the fundamental electrochemical studies and subsequent applications of MXenes for molecular sensing are still in their infancy. Here, we use 2D sheets of titanium carbide (Ti3C2Tx) MXene for electrochemical detection of phosphate, a key molecule for sustainability of life on earth, and major contributor to environmental pollution. Ti3C2Tx MXene sensors were demonstrated to be highly selective towards phosphate with a sensing range from 1 µM to 350 µM and a limit of detection (LOD) of 1.31 µM. This work lays the foundation for molecular sensing using Ti3C2Tx MXene in complex environments.

从研究土壤-水系统中的营养物质到评估人类健康的生理状况,快速、准确地检测具有高度选择性和灵敏度的分子物种构成了设计各种应用传感器的最终目标。随着近年来的进展,二维(2D)过渡金属碳化物/氮化物在储能和电磁干扰屏蔽等方面显示出巨大的应用潜力。然而,MXenes在分子传感方面的基础电化学研究和后续应用仍处于起步阶段。在这里,我们使用二维碳化钛(Ti3C2Tx) MXene薄片对磷酸盐进行电化学检测,磷酸盐是地球上生命可持续发展的关键分子,也是环境污染的主要贡献者。Ti3C2Tx MXene传感器对磷酸盐具有高度选择性,传感范围为1µM至350µM,检测限(LOD)为1.31µM。这项工作为在复杂环境中使用Ti3C2Tx MXene进行分子传感奠定了基础。
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引用次数: 0
Continuous tuning of ejector parameters via zeotropic component migration for optimising high-temperature heat pump. 通过共沸组分迁移对喷射器参数进行连续调整以优化高温热泵。
Pub Date : 2025-11-12 DOI: 10.1038/s44172-025-00518-y
Zhengyong Li, Youcai Liang, Yan Zhu, Shunchun Yao, Zhibin Yu

As the temperature lift increases, heat pump performance declines due to rising throttling losses in expansion valves. Ejectors present a promising alternative, enabling power recovery from the throttling process. However, fixed-geometry ejectors suffer performance degradation under off-design conditions. Here we propose leveraging the component migration characteristics of zeotropic refrigerants to continuously adjust critical ejector parameters by modulating the quality. This approach enables optimal performance across varying conditions without mechanical modifications. A vapor-injection heat pump cycle incorporating a component-adjustable ejector with three tunable parameters is developed. The concept of equivalent ejector efficiency was introduced, and the adjustment capability of typical high-temperature refrigerant mixtures was investigated, such as mixtures of butane (R600) and synthetic refrigerants (R245fa). Results show that, at a nominal heating capacity of 100 kW, R600/R245fa achieves a lower adjustable limit of -5%, compared to -2% for R1224yd(Z)/R1233zd(E) (synthetic refrigerant mixtures). These findings demonstrate the feasibility of efficient operation of fixed-geometry ejectors under variable conditions. The proposed system and regulation strategy offer a promising design alternative for industrial high-temperature heat pump applications.

随着温度提升的增加,由于膨胀阀节流损失的增加,热泵性能下降。喷射器是一种很有前途的替代方案,可以从节流过程中回收功率。然而,在非设计条件下,固定几何喷射器的性能会下降。在此,我们建议利用共沸制冷剂的组分迁移特性,通过调节质量来连续调整关键喷射器参数。这种方法可以在不同的条件下实现最佳性能,而无需进行机械修改。研制了一种具有三个可调参数的组件可调喷射器的蒸汽喷射热泵循环。引入了等效喷射器效率的概念,研究了丁烷(R600)与合成制冷剂(R245fa)混合等典型高温制冷剂的调节能力。结果表明,在100kw的标称供热能力下,R600/R245fa的可调限值为-5%,而R1224yd(Z)/R1233zd(E)(合成制冷剂混合物)的可调限值为-2%。这些发现证明了固定几何喷射器在可变条件下高效工作的可行性。所提出的系统和调节策略为工业高温热泵应用提供了一个有前途的设计方案。
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引用次数: 0
Enabling multirotor UAVs to perch, land and detach with standard propeller guards. 使多旋翼无人机能够停泊,着陆和分离与标准螺旋桨保护。
Pub Date : 2025-11-11 DOI: 10.1038/s44172-025-00514-2
Yuying Zou, Haotian Li, Yunfan Ren, Fanze Kong, Wei Xu, Yihang Li, Yixi Cai, Fu Zhang

The widespread adoption of multirotor uncrewed aerial vehicles (UAVs) is hindered by limited flight time and degraded stability to wind disturbances. Perching, inspired by birds, offers a solution by saving energy and maintaining stability. However, current perching methods often rely on heavy mechanisms, have limitations on surface materials, and obstruct vision sensors. In this study, we propose a process to enable multirotors to perch, land, and detach, all with standard propeller guards. This approach eliminates additional mechanisms, avoids sensor interference, and significantly reduces energy consumption by leveraging the ceiling effect. In over 150 perching and detaching tests with various surface orientations and materials, the approach achieved a 100% success rate and saved 25% - 100% energy consumption compared to hovering. It also improved positioning accuracy by 50 times under strong winds by ensuring stable environmental contact. We demonstrated in real-world environments, showcasing the autonomous perching and detaching ability using only onboard sensing and computation.

多旋翼无人飞行器(uav)的广泛采用受到飞行时间有限和对风扰动稳定性下降的阻碍。栖息的灵感来自鸟类,提供了一种既节约能源又保持稳定的解决方案。然而,目前的栖息方法往往依赖于重型机械,对表面材料有限制,并且阻碍视觉传感器。在这项研究中,我们提出了一个过程,使多旋翼悬停,着陆和分离,所有与标准螺旋桨保护。这种方法消除了额外的机制,避免了传感器干扰,并通过利用天花板效应显著降低了能耗。在150多次不同表面取向和材料的悬停和分离测试中,该方法取得了100%的成功率,与悬停相比节省了25% - 100%的能耗。它还通过确保稳定的环境接触,将强风下的定位精度提高了50倍。我们在现实环境中进行了演示,展示了仅使用车载传感和计算的自主停泊和分离能力。
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引用次数: 0
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Communications engineering
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