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4H silicon carbide bulk acoustic wave gyroscope with ultra-high Q-factor for on-chip inertial navigation 用于片上惯性导航的超高 Q 因子 4H 碳化硅体声波陀螺仪
Pub Date : 2024-06-25 DOI: 10.1038/s44172-024-00234-z
Zhenming Liu, Yaoyao Long, Charlotte Wehner, Haoran Wen, Farrokh Ayazi
Inertial navigation on a chip has long been constrained by the noise and stability issues of micromechanical Coriolis gyroscopes, as silicon, the dominant material for microelectromechanical system devices, has reached the physical limits of its material properties. To address these challenges, this study explores silicon carbide, specifically its monocrystalline 4H polytype, as a substrate to improve gyroscope performance due to its low phonon Akhiezer dissipation and its isotropic hexagonal crystal lattice. We report on low-noise electrostatic acoustic resonant gyroscopes with mechanical quality factors exceeding several millions, fabricated on bonded 4H silicon carbide-on-insulator wafers. These gyroscopes operate using megahertz frequency bulk acoustic wave modes for large open-loop bandwidth and are tuned electrostatically using capacitive transducers created by wafer-level deep reactive ion etching. Experimental results show these gyroscopes achieve superior performance under various conditions and demonstrate higher quality factors at increased temperatures, enabling enhanced performance in an ovenized or high-temperature stabilized configuration. Zhenming Liu and colleagues show a SiC microelectromechanical system with both high quality factor and high frequency. They demonstrate the advantage of the device over the traditional Si gyroscopes and batch-fabrication possibility.
长期以来,芯片惯性导航一直受制于微机械科里奥利陀螺仪的噪声和稳定性问题,因为微机电系统设备的主要材料硅已经达到了其材料特性的物理极限。为了应对这些挑战,本研究探索将碳化硅(特别是其单晶 4H 多晶型)作为基底,以改善陀螺仪的性能,因为碳化硅的声子阿基泽耗散较低,且具有各向同性的六边形晶格。我们报告的低噪声静电声共振陀螺仪,其机械品质因数超过几百万,是在粘结的 4H 碳化硅-绝缘体晶片上制造的。这些陀螺仪使用兆赫兹频率的体声波模式运行,具有较大的开环带宽,并通过晶圆级深反应离子蚀刻产生的电容换能器进行静电调谐。实验结果表明,这些陀螺仪在各种条件下都能实现卓越的性能,并在温度升高时表现出更高的品质因数,从而提高了烘箱或高温稳定配置的性能。Zhenming Liu 及其同事展示了一种具有高品质因数和高频率的碳化硅微机电系统。他们展示了该器件相对于传统硅陀螺仪的优势以及批量制造的可能性。
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引用次数: 0
Spinouts bring women in engineering together — here’s why 自创项目将工程领域的女性聚集在一起--原因如下
Pub Date : 2024-06-24 DOI: 10.1038/s44172-024-00228-x
Brittany Harris, Jade Cohen, Irena Tyshyna, Anna Baldycheva
This International Women in Engineering Day (INWED 2024) Communications Engineering celebrates women in innovative startups.
今年的 "国际工程界妇女日"(INWED 2024),通信工程公司为创新型初创企业中的女性举办了庆祝活动。
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引用次数: 0
5G wavelength-division-multiplexing-based bidirectional optical wireless communication system with signal remodulation employing cascaded reflective semiconductor optical amplifiers 基于 5G 波分复用的双向光无线通信系统,采用级联反射式半导体光放大器进行信号重调
Pub Date : 2024-06-22 DOI: 10.1038/s44172-024-00232-1
Hai-Han Lu, Chung-Yi Li, Xu-Hong Huang, Yu-Yao Bai, Wei-Wen Hsu, Yu-Chen Chung, Jia-Ming Lu, Kelper Okram
Compared with previous generations, fifth-generation communications can provide faster download and upload speeds and support a greater number of connected devices. Integrating fifth-generation signals with optical wireless communication systems provides promising ways to afford higher transmission rates and faster wireless connectivity. Here we report a fifth-generation wavelength-division-multiplexing-based bidirectional optical wireless communication system with signal remodulation employing cascaded reflective semiconductor optical amplifiers to effectively remove the downstream data for uplink transmission. It shows a fifth-generation wavelength-division-multiplexing-based bidirectional optical wireless communication system using four wavelengths for communication. The uplink performance is substantially enhanced by using two reflective semiconductor optical amplifiers to remove the downstream data. The system achieves an aggregate transmission rate of 36.4 Gbit/s for both downlink and uplink transmissions over a 100-m optical wireless link. This demonstrated fifth-generation wavelength-division-multiplexing-based bidirectional optical wireless communication system employing cascaded reflective semiconductor optical amplifiers holds great potential for enhancing fifth-generation advanced communication capabilities. Lu et al. demonstrated a bidirectional optical wireless communication system for 5G communications using wavelength-division multiplexing and cascaded reflective semiconductor optical amplifiers. The system achieves an aggregate rate of 36.4 Gb/s over a 100-m optical wireless link, enhancing 5G communication capabilities.
与前几代通信技术相比,第五代通信技术可提供更快的下载和上传速度,并支持更多的连接设备。将第五代信号与光无线通信系统集成,为实现更高的传输速率和更快的无线连接提供了可行的途径。在此,我们报告了一种基于第五代波分复用技术的双向光无线通信系统,该系统采用级联反射半导体光放大器进行信号重调,以有效去除上行链路传输的下行数据。它展示了一种基于波分复用技术的第五代双向光无线通信系统,该系统使用四种波长进行通信。通过使用两个反射式半导体光放大器去除下行数据,上行链路性能得到大幅提升。该系统在 100 米长的光无线链路上实现了 36.4 Gbit/s 的下行和上行总传输速率。这一基于第五代波分复用技术的双向光无线通信系统采用了级联反射半导体光放大器,在提高第五代先进通信能力方面具有巨大潜力。Lu 等人利用波分复用和级联反射半导体光放大器展示了一种用于 5G 通信的双向光无线通信系统。该系统在 100 米长的光无线链路上实现了 36.4 Gb/s 的总速率,增强了 5G 通信能力。
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引用次数: 0
Insect-inspired breathing interfaces: investigating robustness of coating-free gas entrapping microtextured surfaces under pressure cycles 受昆虫启发的呼吸界面:研究无涂层气体夹带微纹理表面在压力循环下的稳健性
Pub Date : 2024-06-21 DOI: 10.1038/s44172-024-00231-2
Sankara Arunachalam, Muhammad Subkhi Sadullah, Himanshu Mishra
Numerous natural and engineering scenarios necessitate the entrapment of air pockets or bubbles on submerged surfaces. Current technologies for bubble entrapment rely on perfluorocarbon coatings, limiting their sustainability. Herein, we investigated the efficacy of doubly reentrant cavity architecture towards realizing gas-entrapping microtextured surfaces under static and dynamic pressure cycling. The effects of positive (>1 atm), negative (<1 atm), and positive–negative cycles on the stability the gas entrapment inside individual doubly reentrant cavities were studied across a range of pressures, ramp rates, intercycle intervals, and water-column heights. Remarkably, the fate of the trapped air under pressure cycling fell into either of the following regimes: the bubble (i) monotonically depleted (unstable), (ii) remained indefinitely stable (stable), or (iii) started growing (bubble growth). This hitherto unrealized richness of underwater bubble dynamics should guide the development of coating-free technologies and help us understand the curious lives of air-breathing aquatic and marine insects. Sankara Arunachalam and colleagues explore the effects of cyclic pressure on the fate of air trapped inside microtextured surfaces submerged in water. The findings guide the design and function of gas-entrapping microtextured surfaces and offer insights into survival strategies of underwater breathers.
在许多自然和工程应用中,都需要在水下表面夹带气穴或气泡。目前的气泡夹持技术依赖于全氟碳涂层,这限制了其可持续性。在此,我们研究了在静态和动态压力循环下,双复向腔体结构在实现气体夹持微纹理表面方面的功效。我们研究了正循环(1 个大气压)、负循环(1 个大气压)和正负循环在不同压力、斜率、循环间隔和水柱高度下对单个双复向腔内气体夹持稳定性的影响。值得注意的是,在压力循环作用下,被截留空气的命运属于以下两种情况之一:气泡(i)单调消耗(不稳定),(ii)保持无限稳定(稳定),或(iii)开始增长(气泡增长)。这种迄今为止尚未实现的丰富的水下气泡动力学应能指导无涂层技术的发展,并帮助我们了解呼吸空气的水生和海洋昆虫的奇特生活。桑卡拉-阿鲁纳恰拉姆及其同事探索了周期性压力对浸没在水中的微纹理表面内部空气命运的影响。这些发现为微纹理表面的设计和功能提供了指导,并为水下呼吸者的生存策略提供了启示。
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引用次数: 0
A gamepad-like nucleic acid testing device for rapid detection of SARS-CoV-2 via visible nested recombinase polymerase amplification 通过可见巢式重组聚合酶扩增快速检测 SARS-CoV-2 的游戏手柄式核酸检测装置
Pub Date : 2024-06-21 DOI: 10.1038/s44172-024-00229-w
Ce Liu, Baobao Lin, Guohua Yuan, Zhi Geng, Zhe Zhao, Jiacheng Wang, Jingyu Shao, Zhenqi Wang, Yang Xu, Xujuan Yang, Chang Liu, Yingmei Feng, Xin Fan, Jing Wang, Lili Ren, Yan Xiao, Conghui Wang, Guang Shen, Yi Yang, Chao Zhao, Yinqing Li, Peng Liu, Jingwei Bai
Nucleic acid tests are essential for the accurate diagnosis and control of infectious diseases. However, current assays are not easily scalable for a large population, due to the requirement of laboratory settings or special equipment. Here, we developed an integrated box for instant nucleic acid screening which fully integrates nucleic acid release, amplification, and results visualization for self-service standalone test. Importantly, the operation of the box runs on a novel gamepad-like interface, which allows deployment of the box in home settings and operation by users without any prior professional training. The performance of the box is empowered by an RNA extraction-free sample inactivation process and nested recombinase polymerase amplification chemistry and exhibits sensitivity comparable to reverse transcription-quantitative polymerase chain reaction with high specificity for severe acute respiratory syndrome coronavirus 2 RNA in a reaction time of 30 minutes directly from fresh swab sample to results. These innovations make the box a novel platform for a convenient, accurate, and deployable point-of-care testing scheme. Ce Liu, Baobao Lin and colleagues report a rapid and straightforward nucleic acid screening test requiring no professional training or formal medical setting. The device runs on a novel gamepad-like interface and fully integrates nucleic acid release, amplification, and visualization.
核酸检测对准确诊断和控制传染病至关重要。然而,由于需要实验室环境或特殊设备,目前的检测方法不容易扩展到大量人群。在此,我们开发了一种用于核酸即时筛查的集成盒,它完全集成了核酸释放、扩增和结果可视化功能,可用于自助式独立检测。重要的是,该盒子的操作是在一个类似游戏手柄的新颖界面上进行的,用户无需经过任何专业培训即可在家庭环境中部署和操作该盒子。无需提取 RNA 的样本灭活过程和巢式重组聚合酶扩增化学反应增强了该检测盒的性能,其灵敏度可与反转录定量聚合酶链反应相媲美,对严重急性呼吸系统综合征冠状病毒 2 RNA 具有高度特异性,从新鲜拭子样本到检测结果的反应时间仅需 30 分钟。这些创新使该检测盒成为一个新颖的平台,可用于方便、准确和可部署的床旁检测方案。Ce Liu、Baobao Lin 及其同事报告了一种快速、简单的核酸筛查测试,无需专业培训或正规医疗环境。该设备在一个类似游戏手柄的新颖界面上运行,完全集成了核酸释放、扩增和可视化功能。
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引用次数: 0
Automatic beam optimization method for scanning electron microscopy based on electron beam Kernel estimation 基于电子束核估计的扫描电子显微镜自动光束优化方法
Pub Date : 2024-06-20 DOI: 10.1038/s44172-024-00230-3
Yunje Cho, Junghee Cho, Jonghyeok Park, Jeonghyun Wang, Seunggyo Jeong, Jubok Lee, Yun Hwang, Jiwoong Kim, Jeongwoo Yu, Heesu Chung, Hyenok Park, Subong Shon, Taeyong Jo, Myungjun Lee, Kwangrak Kim
Scanning Electron Microscopy (SEM) leverages electron wavelengths for nanoscale imaging, necessitating precise parameter adjustments like focus, stigmator, and aperture alignment. However, traditional methods depend on skilled personnel and are time-consuming. Existing auto-focus and auto-stigmation techniques face challenges due to interdependent nature of these parameters and sample diversity. We propose a beam kernel estimation method to independently optimize SEM parameters, regardless of sample variations. Our approach untangles parameter influences, enabling concurrent optimization of focus, stigmator x, y, and aperture-align x, y. It achieves robust performance, with average errors of 1.00 μm for focus, 0.30% for stigmators, and 0.79% for aperture alignment, surpassing sharpness-based approach with its average errors of 6.42 μm for focus and 2.32% for stigmators and lacking in aperture-align capabilities. Our approach addresses SEM parameter interplay via blind deconvolution, facilitating rapid and automated optimization, thereby enhancing precision, efficiency, and applicability across scientific and industrial domains. Yunje Cho and colleagues improve the resolution of scanning electron microscopes via high-precision auto-focus and auto-stigmation. Their method operates without pre-existing knowledge about the sample.
扫描电子显微镜(SEM)利用电子波长进行纳米级成像,需要对聚焦、定焦器和光圈对准等参数进行精确调整。然而,传统方法依赖于技术熟练的人员,而且耗费时间。现有的自动聚焦和自动定焦技术由于这些参数的相互依赖性和样品的多样性而面临挑战。我们提出了一种光束核估计方法,可独立优化扫描电子显微镜参数,而不受样本变化的影响。该方法性能稳健,聚焦平均误差为 1.00 μm,定影平均误差为 0.30%,光圈对准平均误差为 0.79%,超过了基于锐度的方法(聚焦平均误差为 6.42 μm,定影平均误差为 2.32%,缺乏光圈对准功能)。我们的方法通过盲解卷积解决了扫描电子显微镜参数之间的相互作用,促进了快速和自动优化,从而提高了精度、效率以及在科学和工业领域的适用性。Yunje Cho 及其同事通过高精度自动聚焦和自动散焦提高了扫描电子显微镜的分辨率。他们的方法无需预先了解样品即可运行。
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引用次数: 0
A high-performance deep reservoir computer experimentally demonstrated with ion-gating reservoirs 利用离子门储层实验证明的高性能深层储层计算机
Pub Date : 2024-06-19 DOI: 10.1038/s44172-024-00227-y
Daiki Nishioka, Takashi Tsuchiya, Masataka Imura, Yasuo Koide, Tohru Higuchi, Kazuya Terabe
While physical reservoir computing is a promising way to achieve low power consumption neuromorphic computing, its computational performance is still insufficient at a practical level. One promising approach to improving its performance is deep reservoir computing, in which the component reservoirs are multi-layered. However, all of the deep-reservoir schemes reported so far have been effective only for simulation reservoirs and limited physical reservoirs, and there have been no reports of nanodevice implementations. Here, as an ionics-based neuromorphic nanodevice implementation of deep-reservoir computing, we report a demonstration of deep physical reservoir computing with maximum of four layers using an ion gating reservoir, which is a small and high-performance physical reservoir. While the previously reported deep-reservoir scheme did not improve the performance of the ion gating reservoir, our deep-ion gating reservoir achieved a normalized mean squared error of 9.08 × 10−3 on a second-order nonlinear autoregressive moving average task, which is the best performance of any physical reservoir so far reported in this task. More importantly, the device outperformed full simulation reservoir computing. The dramatic performance improvement of the ion gating reservoir with our deep-reservoir computing architecture paves the way for high-performance, large-scale, physical neural network devices. Daiki Nishioka and colleagues show a nanodevice implementation of deep reservoir computing using an ion-gating reservoir, achieving record-low error rates on a complex computational task. This device is more efficient and scalable for brain-like computing systems exploiting physical systems.
虽然物理水库计算是实现低功耗神经形态计算的一种有前途的方法,但其计算性能在实用层面上仍然不足。提高其性能的一个有前途的方法是深层水库计算,在这种方法中,水库的组成部分是多层的。然而,迄今为止报道的所有深层水库方案都只对模拟水库和有限的物理水库有效,还没有纳米设备实现的报道。在此,作为基于离子技术的神经形态纳米设备的深层存储计算实施方案,我们报告了利用离子门存储库(一种小型高性能物理存储库)实现最多四层深层物理存储计算的演示。虽然之前报道的深层水库方案没有提高离子门控水库的性能,但我们的深层离子门控水库在二阶非线性自回归移动平均任务中实现了 9.08 × 10-3 的归一化均方误差,这是迄今为止报道的物理水库在该任务中的最佳性能。更重要的是,该设备的性能优于全仿真水库计算。采用我们的深度水库计算架构的离子门控水库的性能大幅提高,为高性能、大规模物理神经网络设备铺平了道路。Daiki Nishioka 及其同事展示了利用离子门水库实现深度水库计算的纳米设备,在复杂的计算任务中实现了创纪录的低错误率。对于利用物理系统的类脑计算系统来说,这种设备效率更高、可扩展性更强。
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引用次数: 0
Implementation of binarized neural networks immune to device variation and voltage drop employing resistive random access memory bridges and capacitive neurons 利用电阻式随机存取存储器桥和电容神经元实现不受器件变化和压降影响的二值化神经网络
Pub Date : 2024-06-18 DOI: 10.1038/s44172-024-00226-z
Mona Ezzadeen, Atreya Majumdar, Olivier Valorge, Niccolo Castellani, Valentin Gherman, Guillaume Regis, Bastien Giraud, Jean-Philippe Noel, Valentina Meli, Marc Bocquet, Francois Andrieu, Damien Querlioz, Jean-Michel Portal
Resistive Random Access Memories (ReRAM) arrays provides a promising basement to deploy neural network accelerators based on near or in memory computing. However most popular accelerators rely on Ohm’s and Kirchhoff’s laws to achieve multiply and accumulate, and thus are prone to ReRAM variability and voltage drop in the memory array, and thus need sophisticated readout circuits. Here we propose a robust binary neural network, based on fully differential capacitive neurons and ReRAM synapses, used in a resistive bridge fashion. We fabricated a network layer with up to 23 inputs that we extrapolated to large numbers of inputs through simulation. Defining proper programming and reading conditions, we demonstrate the high resilience of this solution with a minimal accuracy drop, compared to a software baseline, on image classification tasks. Moreover, our solution can achieve a peak energy efficiency, comparable with the state of the art, when projected to a 22 nanometer technology. Mona Ezzadeen and co-authors demonstrate a compute-in memory cell with a low consumed power per operation. In silicon implementation with 23 inputs is successfully used to solve benchmarking tasks of digit recognition.
电阻式随机存取存储器(ReRAM)阵列为部署基于近内存或内存计算的神经网络加速器提供了一个前景广阔的基础。然而,大多数流行的加速器都依赖于欧姆定律和基尔霍夫定律来实现乘法和累加,因此很容易受到 ReRAM 变异和存储器阵列压降的影响,因此需要复杂的读出电路。在此,我们提出了一种基于全差分电容神经元和 ReRAM 突触的稳健二元神经网络,以电阻桥方式使用。我们制作了一个具有多达 23 个输入的网络层,并通过模拟推断出大量输入。通过定义适当的编程和读取条件,我们证明了该解决方案的高弹性,与软件基线相比,它在图像分类任务中的准确率下降幅度极小。此外,当投射到 22 纳米技术上时,我们的解决方案可以达到峰值能效,与最先进的技术不相上下。Mona Ezzadeen 及其合著者展示了一种每次操作功耗较低的内存计算单元。在硅片中实现了 23 个输入,成功地解决了数字识别的基准任务。
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引用次数: 0
Can holographic optical storage displace Hard Disk Drives? 全息光存储能否取代硬盘驱动器?
Pub Date : 2024-06-18 DOI: 10.1038/s44172-024-00225-0
Jiaqi Chu, Nathanaël Cheriere, Grace Brennan, Mengyang Yang, Greg O’Shea, Jannes Gladrow, Douglas J. Kelly, Giorgio Maltese, Alan Sanders, Dushyanth Narayanan, Benn Thomsen, Antony Rowstron
Cloud data workloads require both high capacity at low cost and high access rates. Hard Disk Drives are the dominant media in this application as they are low cost, however, Hard Disk Drive technology is seeing declining access rates and a slowdown in capacity scaling. Holographic data storage could disrupt Hard Disk Drives in the cloud since it may offer both high capacity and access rates. However, a challenge with rewritable holographic media is the data durability due to erasure. Here we present a media and workload aware energy optimization framework and show that erasure can be managed. We investigated the optimal Fe concentrations in iron-doped lithium niobate with experimental results supporting a stretched-exponential erasure model. We achieved a record number of reads, and surpassed the previous record for density. Our approach provides an objective assessment the feasibility of such storage technology given component parameters and material properties. Chu and colleagues explore holographic data storage as a replacement for hard disk drives, introducing an energy optimization framework for Fe concentrations in iron-doped lithium niobate. Their approach results in a record-breaking performance in both read and density.
云数据工作负载需要低成本的大容量和高访问率。硬盘驱动器是这种应用中的主流媒体,因为它们成本低,但是,硬盘驱动器技术的访问率正在下降,容量扩展也在放缓。全息数据存储可能会颠覆云计算中的硬盘驱动器,因为它可能同时提供高容量和高访问率。然而,可重写全息介质面临的一个挑战是擦除导致的数据耐久性问题。在此,我们提出了一个介质和工作负载感知能量优化框架,并证明擦除是可以管理的。我们研究了掺铁铌酸锂中的最佳铁浓度,实验结果支持拉伸-指数擦除模型。我们实现了创纪录的读取次数,并超越了之前的密度记录。我们的方法客观地评估了在元件参数和材料特性条件下这种存储技术的可行性。Chu 及其同事探索了全息数据存储作为硬盘驱动器替代品的可能性,并引入了掺铁铌酸锂中铁浓度的能量优化框架。他们的方法在读取和密度方面都取得了破纪录的性能。
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引用次数: 0
Defective flow space limits the scaling up of turbulence bioreactors for platelet generation 流动空间的缺陷限制了用于生成血小板的湍流生物反应器的规模扩大
Pub Date : 2024-06-17 DOI: 10.1038/s44172-024-00219-y
Haruki Okamoto, Kosuke Fujio, Sou Nakamura, Yasuo Harada, Hideki Hayashi, Natsumi Higashi, Atsushi Ninomiya, Ryota Tanaka, Naoshi Sugimoto, Naoya Takayama, Atsushi Kaneda, Akira Sawaguchi, Yoshikazu Kato, Koji Eto
To complement donor-dependent platelets supplies, we previously developed an ex vivo manufacturing system using induced pluripotent stem cell (iPSC)-derived expandable immortalized megakaryocyte progenitor cell lines (imMKCLs), and a turbulent flow bioreactor to generate iPSC-derived platelets products (iPSC-PLTs). However, the tank size of the bioreactor was limited to 10 L. Here we examined the feasibility of scaling up to 50 L with reciprocal motion by two impellers. Under optimized turbulence parameters corresponding to 10 L bioreactor, 50 L bioreactor elicited iPSC-PLTs with intact in vivo hemostatic function but with less production efficiency. This insufficiency was caused by increased defective turbulent flow space. A computer simulation proposed that designing 50 L turbulent flow bioreactor with three impellers or a new bioreactor with a modified rotating impeller and unique structure reduces this space. These findings indicate that large-scale iPSC-PLTs manufacturing from cultured imMKCLs requires optimization of the tank structure in addition to optimal turbulent energy and shear stress. Haruki Okamoto and colleagues demonstrate that tank structure is crucial for large-scale platelet production from cultured immortalized megakaryocyte progenitor cell lines, due to the increase in defective turbulent flow space. These insights could guide the development of new bioreactors with improved production efficiency.
为了补充依赖供体的血小板供应,我们之前开发了一种体外制造系统,利用诱导多能干细胞(iPSC)衍生的可扩增永生巨核祖细胞系(imMKCLs)和湍流生物反应器生成 iPSC 衍生的血小板产品(iPSC-PLTs)。然而,生物反应器的水箱容量仅限于 10 L。在此,我们研究了利用两个叶轮的往复运动将容积扩大到 50 L 的可行性。在对应 10 升生物反应器的优化湍流参数下,50 升生物反应器诱导出的 iPSC-PLTs 具有完整的体内止血功能,但生产效率较低。这种不足是由于湍流空间缺陷增加造成的。计算机模拟提出,设计具有三个叶轮的 50 升湍流生物反应器或具有改良旋转叶轮和独特结构的新型生物反应器可减少这一空间。这些发现表明,利用培养的 imMKCLs 大规模制造 iPSC-PLTs 除了需要优化湍流能和剪切应力外,还需要优化水槽结构。Haruki Okamoto 及其同事证明,由于缺陷湍流空间的增加,水槽结构对于从培养的永生巨核祖细胞系大规模生产血小板至关重要。这些见解可以指导开发新的生物反应器,提高生产效率。
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引用次数: 0
期刊
Communications engineering
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