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Interaction-based rapid heuristic optimization of exoskeleton assistance during walking. 行走过程中基于交互的外骨骼辅助快速启发式优化。
Pub Date : 2025-12-30 DOI: 10.1038/s44172-025-00574-4
Jianyu Chen, Weihao Yin, Jianquan Ding, Jiaqi Han, Lihai Zhang, Jianda Han, Juanjuan Zhang

Using human responses to optimize and thus personalize assistance enhances exoskeleton performance during locomotion. Current approaches lack efficiency, comfort, rapid deployability, and computation and actuation simplicity. Here we present a method that optimizes assistance within 2 min, 16 times faster than the state-of-the-art, by effectively imitating human joint moment while ensuring stability. Optimization of a unilateral ankle exoskeleton with off-board actuation produced gentler assistance (78.2% torque) while reducing muscle activity by 36.8% and metabolic cost by 20.4% than no assistance, comparable to state-of-the-art. The method was easily and effectively deployed across new gait conditions, to bilateral devices, to knee joints and also outdoors. It largely avoided the problems of existing methods with instantaneously measurable feedback, a non-aggressive tuning process, a reasonable tuning direction, and a non-parametric assistance formulation. By significantly reducing pre-research, operational, user physiological and psychological costs, this method largely elevates the accessibility level of effective, personalized and continuously tuned exoskeletons in everyday scenarios.

利用人的反应优化,从而个性化的援助,提高外骨骼在运动中的性能。目前的方法缺乏效率、舒适性、快速可部署性以及计算和驱动的简单性。在这里,我们提出了一种方法,通过有效地模仿人类关节力矩,同时确保稳定性,在2分钟内优化辅助,比最先进的方法快16倍。与无辅助相比,单侧踝关节外骨骼的优化与非辅助相比,产生了更温和的辅助(78.2%扭矩),同时减少了36.8%的肌肉活动和20.4%的代谢成本,可与最先进的技术相媲美。该方法易于有效地部署在新的步态条件下,双侧装置,膝关节和户外。它在很大程度上避免了现有方法的问题,具有即时可测量的反馈,非侵略性调谐过程,合理的调谐方向和非参数辅助公式。通过显著降低前期研究、操作、用户生理和心理成本,该方法大大提高了在日常场景中有效、个性化和持续调整外骨骼的可及性水平。
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引用次数: 0
Surpassing the diffraction limit for improved lateral resolution in adaptive optics optical coherence tomography of the living human eye. 在自适应光学中超越衍射极限以提高横向分辨率的人眼光学相干断层扫描。
Pub Date : 2025-12-29 DOI: 10.1038/s44172-025-00573-5
Andrew J Bower, Furu Zhang, Tao Liu, Joanne Li, Nancy Aguilera, Sarah Abouassali, Jonathan Krynitsky, Randy Pursley, Tom Pohida, Bartlomiej Kowalski, Rongwen Lu, Alfredo Dubra, Johnny Tam

Advances in adaptive optics optical coherence tomography (AOOCT) have facilitated the three-dimensional assessment of structural and functional properties of individual retinal cells in the living human eye. However, even with diffraction-limited AOOCT systems, some cells in the living human retina can be difficult to resolve, especially when using near-infrared wavelengths of light (~1000 nm). We demonstrate that modifying the traditional AOOCT instrument design to enable annular illumination and sub-Airy disk detection results in improved imaging resolution beyond fundamental limits imposed by diffraction. We successfully applied this approach to in vivo human retinal imaging, achieving on average 36% improvement in lateral resolution beyond conventional imaging conditions, enabling improved visualization of the foveal cone and rod photoreceptor mosaics using AOOCT. These results demonstrate an effective strategy for improving lateral resolution in point-scanning AOOCT in a manner that is compatible with new and existing instruments.

光学相干层析成像技术(AOOCT)的发展促进了对活体人眼视网膜细胞结构和功能特性的三维评估。然而,即使使用衍射有限的AOOCT系统,活体视网膜中的一些细胞也难以分辨,特别是在使用近红外波长的光(~1000 nm)时。我们证明,修改传统的AOOCT仪器设计,使其能够实现环形照明和亚airy盘检测,从而提高了成像分辨率,超出了衍射所施加的基本限制。我们成功地将这种方法应用于人体视网膜成像,在常规成像条件下平均提高36%的横向分辨率,使用AOOCT提高了中央凹锥体和视杆光感受器马赛克的可视化。这些结果证明了一种有效的策略,以一种与新仪器和现有仪器兼容的方式提高点扫描AOOCT的横向分辨率。
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引用次数: 0
A diffusion model-based image generation framework for underwater object detection. 基于扩散模型的水下目标检测图像生成框架。
Pub Date : 2025-12-29 DOI: 10.1038/s44172-025-00579-z
Yaoming Zhuang, Longyu Ma, Jiaming Liu, Yonghao Xian, Baoquan Chen, Li Li, Chengdong Wu, Wei Cui, Zhanlin Liu

Underwater object detection plays a crucial role in applications such as marine ecological monitoring and underwater rescue operations. However, challenges such as limited underwater data availability and low scene diversity hinder detection accuracy. In this paper, we propose the Underwater Layout-Guided Diffusion Framework (ULGF), a diffusion model-based framework designed to augment underwater detection datasets. Unlike conventional methods that generate underwater images by integrating in-air information, ULGF operates exclusively on a small set of underwater images and their corresponding labels, requiring no external data. We have publicly released the ULGF source code and the generated dataset for further research. Our approach enables the generation of high-fidelity, diverse, and theoretically infinite underwater images, substantially enhancing object detection performance in real-world underwater scenarios. Furthermore, we evaluate the quality of the generated underwater images, demonstrating that ULGF produces images with a smaller domain gap.

水下目标探测在海洋生态监测和水下救援等应用中起着至关重要的作用。然而,有限的水下数据可用性和低场景多样性等挑战阻碍了检测的准确性。在本文中,我们提出了水下布局引导扩散框架(ULGF),这是一个基于扩散模型的框架,旨在增强水下探测数据集。与通过整合空中信息生成水下图像的传统方法不同,ULGF只对一小组水下图像及其相应的标签进行操作,不需要外部数据。我们已经公开发布了ULGF源代码和生成的数据集,以供进一步研究。我们的方法能够生成高保真、多样化和理论上无限的水下图像,大大提高了真实水下场景中的目标检测性能。此外,我们评估了生成的水下图像的质量,证明ULGF生成的图像具有较小的域间隙。
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引用次数: 0
Fabrication of cell culture hydrogels by robotic liquid handling automation for high-throughput drug testing. 高通量药物检测用机器人液体处理自动化制备细胞培养水凝胶。
Pub Date : 2025-12-22 DOI: 10.1038/s44172-025-00575-3
Eloisa Torchia, Moises Di Sante, Bohdana Horda, Marko Mihajlovic, Julius Zimmermann, Melissa Pezzotti, Elisa Cimetta, Sylvain Gabriele, Ferdinando Auricchio, Johan Ulrik Lind, Alessandro Enrico, Francesco Silvio Pasqualini

Traditional plastic and glass culture lacks physiological relevance, undermining predictive power in drug discovery. Organoids and organs-on-chip improve biomimicry but do not scale to high-throughput screening (HTS). Even simple hydrogel coatings in HTS plates suffer from curved menisci that disrupt seeding and imaging. We present HYDRA (HYDrogels by Robotic liquid-handling Automation), an automated method to fabricate thin, planar hydrogel films directly in standard plates. Liquid-handlers dispense sub-contact volumes without wall wetting; immediate re-aspiration pins the contact line, leaving a uniform layer with controlled stiffness and thickness. Using fish gelatin hydrogel, HYDRA produces meniscus-free coatings compatible with routine 96- and 384-well workflows and plate-scale quality control. HYDRA was validated through imaging-based dose-response assays with anticancer compounds, engineered epithelial monolayers, and long-term holographic and fluorescence microscopy. It preserved pharmacological sensitivity while supporting high-content imaging on soft, biomimetic substrates, offering a practical bridge between physiological relevance and HTS scalability for early in-vitro drug testing.

传统的塑料和玻璃文化缺乏生理学相关性,削弱了药物发现的预测能力。类器官和芯片上的器官改善了仿生学,但不能扩展到高通量筛选(HTS)。即使是简单的水凝胶涂层在高温超导板遭受弯曲半月板,破坏播种和成像。我们提出HYDRA(机器人液体处理自动化的水凝胶),一种直接在标准板上制造薄的平面水凝胶膜的自动化方法。液体处理机分配无壁润湿的亚接触体积;立即再抽吸固定接触线,留下硬度和厚度可控的均匀层。HYDRA使用鱼明胶水凝胶生产无半月板涂层,与常规96井和384井的工作流程和板级质量控制兼容。HYDRA通过抗癌化合物、工程上皮单层、长期全息和荧光显微镜进行基于成像的剂量反应试验验证。它保留了药理学敏感性,同时支持在柔软的仿生基质上进行高含量成像,为早期体外药物测试提供了生理相关性和HTS可扩展性之间的实用桥梁。
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引用次数: 0
Body-resonance: transmission line-like wireless links enabling high-speed wearable communication. 体共振:类似传输线的无线链路,实现高速可穿戴通信。
Pub Date : 2025-12-20 DOI: 10.1038/s44172-025-00533-z
Samyadip Sarkar, Qi Huang, Sarthak Antal, Mayukh Nath, Shreyas Sen

Seamless interaction between humans and Artificial Intelligence-empowered, battery-operated, miniaturized devices is reshaping wearable technology by forming an anthropomorphic artificial nervous system that demands high-speed, low-power connectivity. Besides being radiative, radio frequency links suffer absorption losses in non-line-of-sight scenarios and consume more than tens of milliwatts of power. Electro-quasistatic human body communication provides non-radiative links with  ~100X better energy efficiency and  ~30X superior signal confinement over radio wave-based wireless. However, it is limited by  ~60-70 dB path loss, limited bandwidth, and data rates ≤30 Mbps, insufficient for applications such as High definition streaming, and distributed computing at wearable sensor nodes. To overcome these challenges, we propose Body-Resonance Human Body Communication, which leverages the human body's transmission-line behavior in the near-intermediate field to enhance channel capacity by up to 30X. It achieves approximately 20 dB higher channel gain and a wider bandwidth compared to electro-quasistatic regime, supporting data rates of hundreds of Mbps. Experimental results validate low-loss (~40-50 dB), wideband body channels that are more than 10X less leaky than antenna-based wireless links. Body Resonance can potentially open up the possibilities of immersive augmented/virtual reality and cooperative on-body computing by enabling energy-efficient, high-speed wearable networks across healthcare, defense, and consumer electronics.

人类与人工智能驱动、电池驱动的小型化设备之间的无缝交互正在重塑可穿戴技术,因为它形成了一种需要高速、低功耗连接的拟人化人工神经系统。除了辐射外,射频链路在非视距情况下还会遭受吸收损失,并消耗超过数十毫瓦的功率。与基于无线电波的无线通信相比,准静电人体通信提供了约100倍更好的能量效率和约30倍优越的信号约束的非辐射链路。然而,它受限于~60- 70db的路径损耗、有限的带宽和≤30mbps的数据速率,不足以满足高清晰度流和可穿戴传感器节点的分布式计算等应用。为了克服这些挑战,我们提出了人体共振人体通信,它利用人体在近中频场中的传输在线行为将信道容量提高了30倍。与准静电系统相比,它实现了大约20 dB的高信道增益和更宽的带宽,支持数百Mbps的数据速率。实验结果验证了低损耗(~40-50 dB)、宽带体信道比基于天线的无线链路泄漏少10倍以上。通过在医疗保健、国防和消费电子产品中实现节能、高速可穿戴网络,身体共振可以潜在地开辟沉浸式增强/虚拟现实和协作式身体计算的可能性。
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引用次数: 0
Sub-THz communication systems: pushing the capabilities of silicon. 次太赫兹通信系统:推动硅的能力。
Pub Date : 2025-12-17 DOI: 10.1038/s44172-025-00545-9
James Gruber, Hamad Alotaibi, Amirata Tabatabavakili, Lili Chen, Hamidreza Aghasi, S M Hossein Naghavi, Ehsan Afshari

Silicon-based technologies have been researched extensively over the past few decades, but one ongoing problem has been bringing these technologies into the sub-THz regime. For wireless communications, these bands exhibit potential for massive improvements to bandwidth, data rates, etc., but overcoming the limits of operating frequency to allow devices to enter the sub-THz regime has proven challenging when designing working systems. Despite this, researchers have been developing novel ways to construct transceiver systems above 200 GHz. In this article, we showcase interesting designs that push the envelope towards more powerful, faster, and more useful silicon-based transceiver systems. We discuss transmitter systems grouped by modulation schemes as well as incoherent and coherent receiver systems. This allows us to point out the specific difficulties seen throughout these works and describe the direction needed to improve these systems. Finally, we discuss the future direction and application of silicon-based wireless communication systems as they move towards sub-THz regions.

在过去的几十年里,人们对硅基技术进行了广泛的研究,但一个持续存在的问题是如何将这些技术引入亚太赫兹区域。对于无线通信,这些频段在带宽、数据速率等方面具有巨大的改进潜力,但在设计工作系统时,克服工作频率的限制以允许设备进入亚太赫兹频段已被证明是具有挑战性的。尽管如此,研究人员一直在开发新的方法来构建200 GHz以上的收发器系统。在本文中,我们展示了一些有趣的设计,这些设计推动了更强大、更快、更有用的硅基收发器系统的发展。我们讨论了按调制方案分组的发射系统,以及非相干和相干接收系统。这使我们能够指出在这些工作中看到的具体困难,并描述改进这些系统所需的方向。最后,我们讨论了硅基无线通信系统向亚太赫兹区域移动的未来方向和应用。
{"title":"Sub-THz communication systems: pushing the capabilities of silicon.","authors":"James Gruber, Hamad Alotaibi, Amirata Tabatabavakili, Lili Chen, Hamidreza Aghasi, S M Hossein Naghavi, Ehsan Afshari","doi":"10.1038/s44172-025-00545-9","DOIUrl":"10.1038/s44172-025-00545-9","url":null,"abstract":"<p><p>Silicon-based technologies have been researched extensively over the past few decades, but one ongoing problem has been bringing these technologies into the sub-THz regime. For wireless communications, these bands exhibit potential for massive improvements to bandwidth, data rates, etc., but overcoming the limits of operating frequency to allow devices to enter the sub-THz regime has proven challenging when designing working systems. Despite this, researchers have been developing novel ways to construct transceiver systems above 200 GHz. In this article, we showcase interesting designs that push the envelope towards more powerful, faster, and more useful silicon-based transceiver systems. We discuss transmitter systems grouped by modulation schemes as well as incoherent and coherent receiver systems. This allows us to point out the specific difficulties seen throughout these works and describe the direction needed to improve these systems. Finally, we discuss the future direction and application of silicon-based wireless communication systems as they move towards sub-THz regions.</p>","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":" ","pages":"213"},"PeriodicalIF":0.0,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12717078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced deep-learning model for temporal-dependent prediction of dynamic behavior of AC losses in superconducting propulsion motors for hydrogen-powered cryo-electric aircraft. 氢动力低温电动飞机超导推进电机交流损耗动态行为随时间变化预测的先进深度学习模型。
Pub Date : 2025-12-17 DOI: 10.1038/s44172-025-00554-8
Shahin Alipour Bonab, Frederick Berg, Wenjuan Song, Alexandre Colle, Mohammad Yazdani-Asrami

Superconducting motors offer high power density, compactness, and efficiency for hydrogen-powered cryo-electric aircraft, but AC operation in cryogenic temperatures produces thermal losses that must be estimated accurately and rapidly at the design stage to optimize efficiency, minimize cryogenic heat load, and maximize specific power density. Traditional modeling approaches fall short-Finite-element is too slow/costly for system-level models, analytical models and look-up tables lack accuracy/flexibility, and earlier intelligent models gave only cycle-averaged (static) losses. Here we demonstrate AI can rapidly and accurately predict dynamic AC losses for superconducting propulsion motors. Using a large dataset of motor configurations, our AI-driven approach both predicts cycle-averaged and time-dependent morphology of instantaneous AC loss waveforms across various operating conditions and generalizes to unseen designs. Integrated into system-level model-based design, these AI-surrogate models enable rapid model trials, compliance checks, and the discovery of integration issues within simulated environments before propulsion motor deployment. Our deep learning-based model achieves a prediction time of less than 9 ms with a 99.97% accuracy (R2), making it suitable for system-level modeling of electric powertrains in hydrogen-powered cryo-electric aircraft. Furthermore, we benchmarked 14 AI and 2 mathematical fitting techniques for estimating average AC losses, providing comparative performance analysis. The results highlight that AI-based surrogate models enable high-accuracy, low-latency loss predictions to achieve optimal performance in superconducting propulsion motors in aircraft powertrain design.

超导电机为氢动力低温电动飞机提供了高功率密度、紧凑性和效率,但在低温下交流运行会产生热损失,必须在设计阶段准确快速地估计热损失,以优化效率、最小化低温热负荷和最大化比功率密度。传统的建模方法不足——对于系统级模型来说,有限元过于缓慢/昂贵,分析模型和查找表缺乏准确性/灵活性,而早期的智能模型只给出周期平均(静态)损失。在这里,我们证明了人工智能可以快速准确地预测超导推进电机的动态交流损耗。使用大量的电机配置数据集,我们的人工智能驱动方法既可以预测各种操作条件下瞬时交流损耗波形的周期平均和时间相关形态,也可以推广到未见过的设计中。这些人工智能代理模型集成到基于系统级模型的设计中,可以实现快速模型试验、合规性检查,并在推进电机部署之前在模拟环境中发现集成问题。我们基于深度学习的模型实现了小于9 ms的预测时间和99.97%的准确率(R2),使其适用于氢动力低温电动飞机电动动力系统的系统级建模。此外,我们对14种人工智能和2种数学拟合技术进行了基准测试,以估计平均交流损耗,并提供了比较性能分析。研究结果表明,基于人工智能的替代模型能够实现高精度、低延迟的损耗预测,从而在飞机动力总成设计中的超导推进电机中实现最佳性能。
{"title":"Advanced deep-learning model for temporal-dependent prediction of dynamic behavior of AC losses in superconducting propulsion motors for hydrogen-powered cryo-electric aircraft.","authors":"Shahin Alipour Bonab, Frederick Berg, Wenjuan Song, Alexandre Colle, Mohammad Yazdani-Asrami","doi":"10.1038/s44172-025-00554-8","DOIUrl":"10.1038/s44172-025-00554-8","url":null,"abstract":"<p><p>Superconducting motors offer high power density, compactness, and efficiency for hydrogen-powered cryo-electric aircraft, but AC operation in cryogenic temperatures produces thermal losses that must be estimated accurately and rapidly at the design stage to optimize efficiency, minimize cryogenic heat load, and maximize specific power density. Traditional modeling approaches fall short-Finite-element is too slow/costly for system-level models, analytical models and look-up tables lack accuracy/flexibility, and earlier intelligent models gave only cycle-averaged (static) losses. Here we demonstrate AI can rapidly and accurately predict dynamic AC losses for superconducting propulsion motors. Using a large dataset of motor configurations, our AI-driven approach both predicts cycle-averaged and time-dependent morphology of instantaneous AC loss waveforms across various operating conditions and generalizes to unseen designs. Integrated into system-level model-based design, these AI-surrogate models enable rapid model trials, compliance checks, and the discovery of integration issues within simulated environments before propulsion motor deployment. Our deep learning-based model achieves a prediction time of less than 9 ms with a 99.97% accuracy (R<sup>2</sup>), making it suitable for system-level modeling of electric powertrains in hydrogen-powered cryo-electric aircraft. Furthermore, we benchmarked 14 AI and 2 mathematical fitting techniques for estimating average AC losses, providing comparative performance analysis. The results highlight that AI-based surrogate models enable high-accuracy, low-latency loss predictions to achieve optimal performance in superconducting propulsion motors in aircraft powertrain design.</p>","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":" ","pages":"221"},"PeriodicalIF":0.0,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12738581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-fidelity hierarchical modeling of lithium-ion batteries: a cross-scale electrochemical-mechanical framework. 锂离子电池的高保真分层建模:跨尺度电化学-机械框架。
Pub Date : 2025-12-16 DOI: 10.1038/s44172-025-00567-3
Xiaoyu Li, Shen Zhao, Chiton Gwan, Zhenpo Wang, Shuqiang Jiao, Yanli Zhu

Mechanical stress during the cycling process notably impacts the performance of lithium-ion batteries (LIBs), making it crucial to accurately monitor stress generation and propagation during battery operation. Traditional electrochemical-mechanical models are limited to the particle and electrode scales, and their parameter identification relies solely on voltage. Here, a multi-scale electrochemical-mechanical-thermal modelling framework with non-destructive parameter identification capabilities is proposed. This numerical model couples electrochemical reactions with thermal effects and links particle-scale strain to electrode-scale displacement. Diffusion-induced stress (DIS) is selected as a key indicator, combined with voltage, to analyze the sensitivity of 23 parameters. A voltage-strain multi-objective parameter identification strategy based on the Pareto front is employed to determine the key parameters. The framework demonstrates high fidelity, with the mean absolute percentage error for voltage and strain predictions below 1% and 3.6%, respectively. This work enables high-fidelity simulation of multi-physics behavior, provides an effective method for calibrating key parameters, and holds potential for establishing a reliable digital twin of LIBs.

循环过程中的机械应力会显著影响锂离子电池的性能,因此准确监测电池运行过程中的应力产生和传播至关重要。传统的电化学力学模型仅限于颗粒和电极尺度,其参数识别仅依赖于电压。本文提出了一种具有非破坏性参数识别能力的多尺度电化学-力学-热建模框架。该数值模型将电化学反应与热效应耦合,并将颗粒级应变与电极级位移联系起来。选择扩散诱发应力(diffusion induced stress, DIS)作为关键指标,结合电压对23个参数的灵敏度进行分析。采用基于Pareto前的电压应变多目标参数辨识策略确定关键参数。该框架具有较高的保真度,电压和应变预测的平均绝对百分比误差分别低于1%和3.6%。这项工作实现了多物理场行为的高保真仿真,提供了校准关键参数的有效方法,并具有建立可靠的lib数字孪生的潜力。
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引用次数: 0
How task-relevant vibratory feedback from an active exoskeleton can lead to ergonomic postures. 来自活动外骨骼的与任务相关的振动反馈如何导致符合人体工程学的姿势。
Pub Date : 2025-12-15 DOI: 10.1038/s44172-025-00552-w
Waldez Gomes, Lucas Quesada, Bastien Berret, Nicolas Vignais, Dorian Verdel

In the past decades, active exoskeletons have been dedicated to reducing human effort, in particular to assist workers in occupational environments. However, this approach does not promote the learning of more ergonomic postures by workers, which is critical for the long-term prevention of musculoskeletal disorders. Alternatively, we propose the use of exoskeletons as biofeedback systems, generating task-relevant perturbations guiding users towards ergonomic postures. To test this approach, participants performed reach-to-hold movements towards a redundant target, allowing multiple final postures. We then introduced vibrations with posture-dependent intensity, generating a sensorimotor disturbance that canceled out either above or below each participant's nominal preferred posture. Interestingly, participants adapted to minimize the vibrations, whether it increased or decreased the gravity efforts, and retained the novel posture when it induced lower effort. Finally, all participants significantly reduced effort post-exposure. This work demonstrates the feasibility of using exoskeletons as biofeedback systems to improve posture, paving the path for applications in musculoskeletal disorders prevention.

在过去的几十年里,活性外骨骼一直致力于减少人类的劳动,特别是在职业环境中帮助工人。然而,这种方法并不能促进工人学习更符合人体工程学的姿势,这对于长期预防肌肉骨骼疾病至关重要。或者,我们建议使用外骨骼作为生物反馈系统,产生与任务相关的扰动,指导用户采取符合人体工程学的姿势。为了测试这种方法,参与者对一个多余的目标进行了手握动作,允许多种最终姿势。然后,我们引入了与姿势相关的振动强度,产生了一种感觉运动干扰,这种干扰会抵消每个参与者的名义上的首选姿势。有趣的是,参与者适应最小化振动,无论是增加还是减少重力的努力,并保持新的姿势,当它引起较低的努力。最后,所有参与者在暴露后都显著减少了努力。这项工作证明了使用外骨骼作为生物反馈系统来改善姿势的可行性,为预防肌肉骨骼疾病的应用铺平了道路。
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引用次数: 0
Reinforced optical cage systems enable drift-free single-molecule localization microscopy. 增强光学笼系统使无漂移的单分子定位显微镜。
Pub Date : 2025-12-15 DOI: 10.1038/s44172-025-00566-4
Hao Qiu, Matthew C Tang, Selene K Roberts, Guoli Li, Rong Su, Marisa L Martin-Fernandez, David T Clarke, Shugang Liu, Xiaojie Liu, Lin Wang

Single-molecule localization microscopy achieves nanometer-scale resolution but is compromised by sample drift during image acquisition. Here we present reinforced optical cage systems, a novel approach that eliminates drift at its mechanical source rather than correcting it through complex image post-processing or fiducial markers. Reinforced optical cage systems employ perforated optomechanical components interconnected by tungsten-steel rods in a design proven by mechanical stability simulations. Our bench-top microscope, built with reinforced optical cage systems, demonstrated exceptional three-dimensional stability, with mean cumulative lateral drift of approximately 5 nanometers over 2 h in widefield fluorescence microscopy and 11-16 nanometers over 15 min in single-molecule localization microscopy, free from measurable axial drift. This development allows super-resolution microscopy to reach its full resolution without the necessity of sample drift correction, offering a straightforward, cost-effective, low-maintenance, and readily accessible solution to high-performance super-resolution microscopy. By addressing the fundamental issue of mechanical instability, reinforced optical cage systems enable improved precision instrumentation for the broader scientific and engineering community.

单分子定位显微镜达到纳米级分辨率,但在图像采集过程中受到样品漂移的影响。在这里,我们提出了增强光学笼系统,这是一种新的方法,可以消除其机械源的漂移,而不是通过复杂的图像后处理或基准标记来纠正它。增强型光学笼系统采用由钨钢棒连接的穿孔光学机械部件,其设计经过机械稳定性模拟验证。我们的台式显微镜,采用强化光学笼系统,显示出卓越的三维稳定性,在宽视场荧光显微镜下,平均累积横向漂移约为5纳米/ 2小时,在单分子定位显微镜下,平均累积横向漂移约为11-16纳米/ 15分钟,没有可测量的轴向漂移。这一发展允许超分辨率显微镜达到其全分辨率,而无需样品漂移校正,为高性能超分辨率显微镜提供直接,经济高效,低维护和易于访问的解决方案。通过解决机械不稳定的基本问题,增强光学笼系统可以为更广泛的科学和工程界提供改进的精密仪器。
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引用次数: 0
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