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Staged modulation using synergistic alkaline biochar-ferrate enhances medium-chain fatty acid production from waste activated sludge. 利用协同碱性生物炭-高铁酸盐分阶段调节提高了废活性污泥中链脂肪酸的产量。
Pub Date : 2025-12-04 DOI: 10.1038/s44172-025-00558-4
Yufen Wang, Ya Ji, Xiaofeng Luo, Tingting Zhu, Bing-Jie Ni, Yiwen Liu

Medium-chain fatty acids (MCFAs) are carbon-neutral alternative to petroleum-derived chemicals, offering sustainable valorization for waste activated sludge. Current bioproduction systems, however, face a critical dual bottleneck stemming from complex sludge matrices and inefficient carbon flux regulation. Here, we develop a stage-optimized modulation strategy employing alkaline biochar (AlkBC)-ferrate to sequentially enhance sludge solubilization and targeted MCFA-producing fermentation. Maximum MCFA production reaches 10495.0 mg chemical oxygen demand L-1, 20.6-, 15.2- and 2.3-fold higher than the control, AlkBC-alone and ferrate-alone groups, respectively. Mechanistically, AlkBC initiates ferrate activation to produce metastable Fe(IV)/Fe(V) intermediates via physical adsorption, electron donation, and oxygen-functionalized coordination. High-valent Fe species oxidation coupled with AlkBC-elevated alkalinity efficiently disrupts sludge polymerized structure and drives bioconversion of released organics. Simultaneously, AlkBC is structurally reconfigured due to ferrate oxidation with surface-loaded Fe₂O3 as active component, substantially enhancing chain elongation. Furthermore, AlkBC-ferrate enriches key functional bacteria while suppressing methanogens, steering carbon flux towards MCFA production.

中链脂肪酸(MCFAs)是石油衍生化学品的碳中性替代品,可为废弃活性污泥提供可持续增值。然而,目前的生物生产系统面临着一个关键的双重瓶颈,源于复杂的污泥基质和低效的碳通量调节。在这里,我们开发了一种阶段优化的调节策略,使用碱性生物炭(AlkBC)-高铁酸盐依次增强污泥的增溶性和靶向mcfa生产发酵。最大MCFA产量达到10495.0 mg化学需氧量l - 1,20.6 -, 15.2-和2.3倍分别高于对照组,单独alkbc组和单独高铁酸盐组。机制上,AlkBC启动高铁酸盐活化,通过物理吸附、电子捐赠和氧功能化配位产生亚稳的Fe(IV)/Fe(V)中间体。高价铁氧化与alkbc升高的碱度相结合,有效地破坏了污泥的聚合结构,并推动了释放的有机物的生物转化。同时,由于高铁酸盐氧化,表面负载的Fe₂O3作为活性成分,AlkBC的结构被重新配置,大大提高了链的延伸率。此外,alkbc -高铁酸盐丰富了关键的功能细菌,同时抑制了产甲烷菌,将碳通量转向MCFA的生产。
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引用次数: 0
Exploring five types of beam shaping using tiled-aperture coherent beam combining. 探索了五种利用平铺孔径相干光束组合进行光束整形的方法。
Pub Date : 2025-12-02 DOI: 10.1038/s44172-025-00562-8
Yunhui Xie, James A Grant-Jacob, Matthew Praeger, Michalis N Zervas, Ben Mills

Coherent Beam Combination (CBC) presents a promising solution to circumvent the power-scaling limitations of High-Power Fiber Lasers (HPFLs) by spatially combining the outputs of multiple independently pumped fibres. This parallel pumping configuration allows each fibre to operate below the critical threshold that would otherwise lead to instability, whilst their combined output exceeds the maximum power achievable from a stably operating HPFL. In this work, we demonstrate that manipulating the relative phases between fibre outputs extends the capabilities of CBC to approximate the phase profiles of optical elements such as spherical lenses, axicon lenses, and spiral phase plates, enabling versatile beam focus shaping and steering. We further show that the combined beam focus, whether coherently combined or shaped into a bespoke profile (e.g. Bessel-like, orbital angular momentum), can be steered and rotated in three-dimensional space through phase-only control. These results are experimentally validated through spatial light modulation to simulate collimated fibre outputs with controllable relative phases. Our findings advance CBC systems beyond mere power scaling, offering pathways for highly versatile beam shaping and steering, with implications for next-generation multifunctional optical power delivery systems.

相干光束组合(CBC)通过在空间上组合多个独立泵浦光纤的输出,为克服高功率光纤激光器(HPFLs)的功率缩放限制提供了一种很有前途的解决方案。这种并联泵浦配置允许每根光纤在低于临界阈值的情况下运行,否则将导致不稳定,而它们的联合输出超过了稳定运行的HPFL所能达到的最大功率。在这项工作中,我们证明了操纵光纤输出之间的相对相位扩展了CBC的能力,以近似光学元件(如球面透镜、轴透镜和螺旋相位板)的相位轮廓,从而实现了多用途的光束焦点塑造和转向。我们进一步表明,无论是相干组合还是形成定制轮廓(例如贝塞尔,轨道角动量),组合光束焦点都可以通过仅相位控制在三维空间中进行操纵和旋转。通过空间光调制模拟具有可控相对相位的准直光纤输出,实验验证了这些结果。我们的研究结果使CBC系统超越了单纯的功率缩放,为高度通用的光束整形和转向提供了途径,对下一代多功能光功率传输系统具有重要意义。
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引用次数: 0
Field-effect detected magnetic resonance of nitrogen-vacancy centers in diamond based on all-carbon Schottky contacts. 基于全碳肖特基触点的场效应检测了金刚石中氮空位中心的磁共振。
Pub Date : 2025-12-02 DOI: 10.1038/s44172-025-00541-z
Xuan Phuc Le, Ludovic Mayer, Simone Magaletti, Martin Schmidt, Jean-François Roch, Thierry Debuisschert

The nitrogen-vacancy (NV) center is a defect in diamond whose spin state can be read optically by exploiting its photoluminescence or electrically by exploiting its charge generation rate under illumination, both of which being spin-dependent. The latter method offers numerous opportunities in terms of integration and performance compared to conventional optical readout. Here, we investigate the physical properties of a graphitic-diamond-graphitic structure under illumination. We show how, for a type IIa diamond material, electron-hole pairs generated by an ensemble of NV centers lead to a p-type material upon illumination, making this all-carbon structure equivalent to two back-to-back Schottky diodes. We analyze how the reverse current flowing upon illumination changes as a function of bias voltage and radiofrequency-induced excitation of the NV ensemble spin resonances. Furthermore, we demonstrate how an additional field effect arising from the illumination scheme affects the reverse current, resulting in a photoelectrical signal that can exceed the optical signal under the same illumination conditions.

氮空位(NV)中心是金刚石中的一个缺陷,其自旋状态可以利用其光致发光进行光学读取,也可以利用其在光照下的电荷产生速率进行电学读取,两者都与自旋有关。与传统的光学读出相比,后一种方法在集成和性能方面提供了许多机会。在这里,我们研究了在光照下石墨-金刚石-石墨结构的物理性质。我们展示了,对于IIa型金刚石材料,由NV中心集合产生的电子-空穴对如何在照明下导致p型材料,使这种全碳结构相当于两个背靠背的肖特基二极管。我们分析了照射后的反向电流随偏置电压和NV系综自旋共振的射频激发的变化情况。此外,我们还演示了由照明方案产生的附加场效应如何影响反向电流,从而导致在相同照明条件下光电信号可以超过光信号。
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引用次数: 0
Towards clinical magnetic particle imaging: safety measurements of medical implants in a human cadaver model. 临床磁颗粒成像:人体尸体模型中医用植入物的安全性测量。
Pub Date : 2025-12-01 DOI: 10.1038/s44172-025-00561-9
Franz Wegner, Thomas Friedrich, Patrick Naoki Elfers, Florian Kleefeldt, Dominik Peter, Philipp Gruschwitz, Teresa Reichl, Johanna Günther, Thomas Kampf, Martin A Rückert, Volker C Behr, Thorsten M Buzug, Roman Kloeckner, Jörg Barkhausen, Thorsten A Bley, Patrick Vogel, Viktor Hartung

Magnetic Particle Imaging (MPI) is a preclinical imaging modality with potential for future clinical usage. The radiation-free guidance of endovascular interventions with MPI is especially promising. Here, we present a safety study on the heating of metallic medical implants during MPI measurements under realistic conditions in an extracorporeally-perfused cadaver model. The measurements were conducted by fiberoptic thermometers and showed no detectable heating of the tested endovascular devices in the cadaver model. A temperature increase of no more than 0.11 K was observed on the surface of the investigated proximal femoral nail. The in vitro testing of orthopedic prostheses (knee and hip) revealed a slight heating effect of 0.45 K. The dependence of heating on the applied excitation frequency was measured. Overall, the tested repertoire of implants did not heat by a clinically-relevant amount in a human-sized MPI-scanner under realistic conditions, indicating their safe usage in future clinical applications.

磁颗粒成像(MPI)是一种具有临床应用潜力的临床前成像技术。利用MPI进行血管内介入治疗的无辐射指导尤其有前景。在此,我们提出了一项在体外灌注尸体模型的现实条件下,在MPI测量期间金属医学植入物加热的安全性研究。测量是通过光纤温度计进行的,在尸体模型中没有检测到被测血管内装置的加热。观察到所研究的股骨近端钉表面温度升高不超过0.11 K。骨科假体(膝关节和髋关节)的体外测试显示轻微的加热效应为0.45 K。测量了加热与外加激励频率的关系。总的来说,在现实条件下,在人体大小的mpi扫描仪中,所测试的植入物没有被临床相关的量加热,这表明它们在未来的临床应用中是安全的。
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引用次数: 0
OpenDosimeter: Open hardware personal X-ray dosimeter. OpenDosimeter:开放式硬件个人x射线剂量计。
Pub Date : 2025-12-01 DOI: 10.1038/s44172-025-00540-0
Norah Ger, Alice Ku, Jasmyn Lopez, N Robert Bennett, Jia Wang, Grace Ateka, Enoch Anyenda, Matthias Rosezky, Pamela Kilavi, Adam S Wang, Kian Shaker

Radiation workers need accurate monitoring of X-ray exposure, but existing solutions are either inaccessible, expensive, or provide delayed feedback. We present OpenDosimeter ( www.opendosimeter.org ), an open hardware solution for real-time personal X-ray dose monitoring. Using a scintillator-based X-ray sensor on a custom board powered by a Raspberry Pi Pico, OpenDosimeter provides real-time feedback (1 Hz), data logging (10 hours), and battery-powered operation. A core innovation is that we calibrate the device using 241Am found in ionization smoke detectors. Specifically, we use the γ-emissions to spectrally calibrate the dosimeter, then calculate the effective dose from X-ray exposure using the scintillator absorption efficiency and energy-to-dose coefficients derived from public tabulated data. We demonstrate that this transparent approach enables dose rate readings with linear response between 0.1-1000 μSv/h at  ± 25% accuracy, tested for energies up to 120 keV. The maximum dose rate readings are limited by pile-up effects when approaching count rate saturation (~77,000 counts per second at  ~13 μs average pulse-processing time). The total cost for making an OpenDosimeter is <$100, which, combined with its open design, enables cost-effective local reproducibility on a global scale. This paper complements the open-source documentation by explaining the underlying technology, algorithms, and areas for future improvement.

辐射工作人员需要精确监测x射线照射情况,但现有的解决方案要么难以获得,要么价格昂贵,要么提供延迟的反馈。我们提出了OpenDosimeter (www.opendosimeter.org),这是一种用于实时个人x射线剂量监测的开放式硬件解决方案。OpenDosimeter采用基于闪烁体的x射线传感器,安装在由Raspberry Pi Pico驱动的定制板上,提供实时反馈(1hz)、数据记录(10小时)和电池供电。一个核心创新是我们使用电离烟雾探测器中的241Am来校准设备。具体来说,我们使用γ辐射光谱校准剂量计,然后使用闪烁体吸收效率和从公开表格数据中得出的能量-剂量系数计算x射线照射的有效剂量。我们证明,这种透明的方法可以在±25%的精度下实现0.1-1000 μSv/h的线性响应剂量率读数,测试能量高达120 keV。当接近计数率饱和时,最大剂量率读数受到堆积效应的限制(在~13 μs的平均脉冲处理时间下每秒~77,000个计数)。制作一个开放剂量计的总成本是
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引用次数: 0
Shape-morphable origami electromagnetic waveguides. 可变形折纸电磁波导。
Pub Date : 2025-12-01 DOI: 10.1038/s44172-025-00539-7
Nikhil Ashok, Sangwoo Suk, Sven G Bilén, Xin Ning

Electromagnetic waveguides are widely used in spacecraft, naval, electrical, and communication systems for transferring microwave energy. Conventional designs are typically rigid and bulky, offering little shape adaptability. This limits their use in confined spaces or systems requiring compact storage and high adaptability. Here we report highly shape-morphable origami electromagnetic waveguides that fold, deploy, and change shape. Inspired by origami folding techniques, including shopping bags and bellows designs, these waveguides demonstrate low-loss, robust microwave energy transmission in numerical and experimental studies. Results demonstrate that highly shape-morphable electromagnetic waveguides may effectively replace rigid counterparts including straight, twisted, and bent waveguides. This research employs a combined analytical and experimental framework to study the kinematics and mechanics of key geometries, particularly rectangular straight and twist bellows designs, offering rigorous structural design guidance. Engineering advancements and fundamental studies in this work lay the foundation for future adaptive microwave energy delivery waveguides.

电磁波导广泛应用于航天器、舰船、电气和通信系统中,用于传输微波能量。传统的设计通常是刚性和笨重的,提供很少的形状适应性。这限制了它们在密闭空间或需要紧凑存储和高适应性的系统中的使用。在这里,我们报告高度形状可变形的折纸电磁波导折叠,部署和改变形状。受折纸折叠技术的启发,包括购物袋和风箱设计,这些波导在数值和实验研究中展示了低损耗,强大的微波能量传输。结果表明,高度可变形的电磁波导可以有效地取代刚性波导,包括直波导、扭曲波导和弯曲波导。本研究采用分析与实验相结合的框架研究关键几何形状的运动学和力学,特别是矩形直波纹管和扭转波纹管的设计,为结构设计提供严格的指导。本工作的工程进展和基础研究为未来的自适应微波能量传输波导奠定了基础。
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引用次数: 0
Efficient air purification using porous ceramic-based bubble-enhanced filtration system. 高效空气净化采用多孔陶瓷基气泡增强过滤系统。
Pub Date : 2025-11-29 DOI: 10.1038/s44172-025-00559-3
Junkai Ren, Ran Gao, Angui Li, Thomas Olofsson, Bingye Song, Ao Tian, Yingying Wang, Yibu Gao, Ying Zhang, Changqing Yang

Conventional dry filtration materials present a high initial efficiency but suffer from poor regenerability and limited functionality. Conversely, liquid-based purification strategies leverage the high capture potential of gas-liquid interfaces, but face challenges such as insufficient material strength, complex fabrication, and difficulties in large-scale application. Here, we proposed a porous ceramic-based bubble-enhanced filtration system (PCBEFS). The proposed system employs tunable porous ceramics as bubble generators in the water medium, thereby enabling highly efficient wet removal of particulate matter, while simultaneously providing air humidification, formaldehyde removal, and antibacterial functions. Furthermore, we established an empirical mathematical model linking pore structure, bubble characteristics, and removal performance, which elucidates the structure-activity relationship and presents insights into the capture mechanism jointly governed by porous ceramics and gas-liquid interfaces. PCBEFS addresses the limitations of the existing liquid-based purification systems and contributes substantially to multifunctional indoor air pollution control with strong engineering potential.

传统的干式过滤材料初始效率高,但可再生性差,功能有限。相反,基于液体的净化策略利用了气液界面的高捕获潜力,但面临着材料强度不足、制造复杂和大规模应用困难等挑战。在此,我们提出了一种多孔陶瓷基气泡增强过滤系统(PCBEFS)。该系统采用可调多孔陶瓷作为水介质中的气泡发生器,从而实现高效的湿法去除颗粒物,同时提供空气加湿、甲醛去除和抗菌功能。此外,我们建立了连接孔隙结构、气泡特征和去除性能的经验数学模型,阐明了结构-活性关系,并对多孔陶瓷和气液界面共同控制的捕获机制提出了见解。PCBEFS解决了现有液体净化系统的局限性,对多功能室内空气污染控制有很大的贡献,具有很强的工程潜力。
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引用次数: 0
Single photon event-driven 3D imaging. 单光子事件驱动的三维成像。
Pub Date : 2025-11-29 DOI: 10.1038/s44172-025-00555-7
Alex Vicente Sola, Matthias Aquilina, Paul Kirkland, Ashley Lyons

Event-based imaging is at the forefront of high-speed sensing applications due to the low latency of asynchronous detection and low data volume. Conventionally, events used in this form of sensing correspond to changes in intensity on the microsecond scale, this inherently makes the approach incompatible with scenarios where single photon detection is required such as single photon Light Detection and Ranging (LiDAR), and low-light-level imaging. Here we propose a new imaging modality which is driven instead by events generated from the detection of individual photons. We use a form of single-pixel imaging in which information from a 3-Dimensional scene is encoded entirely in the time-of-arrival of the photons such that each detected photon can be used to update an estimation of all transverse positions simultaneously. The image reconstruction is performed by a Spiking Convolutional Neural Network (SCNN) which has a natural complementarity with single photon detection that allows the scheme to run fully asynchronously and be driven by the detection of each individual photon. Our approach for processing LiDAR information asynchronously, driven by each detected photon, has the potential for minimal latency 3D imaging and sensing even in weak light conditions with applications in high speed target detection and robotics.

由于异步检测的低延迟和低数据量,基于事件的成像处于高速传感应用的前沿。通常,在这种形式的传感中使用的事件对应于微秒尺度上的强度变化,这本质上使得该方法与需要单光子探测的场景不兼容,例如单光子光探测和测距(LiDAR),以及微光成像。在这里,我们提出了一种新的成像模式,它是由单个光子探测产生的事件驱动的。我们使用一种单像素成像形式,其中来自三维场景的信息完全在光子到达时间内编码,这样每个检测到的光子可以用来同时更新所有横向位置的估计。图像重建由一个脉冲卷积神经网络(SCNN)执行,该网络与单光子检测具有天然的互补性,允许该方案完全异步运行,并由每个单个光子的检测驱动。我们异步处理激光雷达信息的方法,由每个检测到的光子驱动,即使在弱光条件下,也有可能实现最小延迟的3D成像和传感,并应用于高速目标检测和机器人技术。
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引用次数: 0
Reliable and efficient transcranial magnetic stimulation-electroencephalography (TMS-EEG) using ultra-thin active electrodes. 使用超薄有源电极可靠高效的经颅磁刺激-脑电图(TMS-EEG)。
Pub Date : 2025-11-28 DOI: 10.1038/s44172-025-00538-8
Johannes Gruenwald, Leonhard Schreiner, Sebastian Sieghartsleitner, Alexandru Buzamat, Giovanni Lombardi, Antonio Calzone, Marco Fummo, Slobodan Tanackovic, Marian-Silviu Poboroniuc, Rossella Spataro, Agnese Zazio, Marta Bortoletto, Christoph Guger

Transcranial magnetic stimulation combined with electroencephalography enables direct assessment of cortical excitability and connectivity via stimulation-evoked responses. While passive electrodes remain the gold standard, they require extensive preparation and are sensitive to contact quality, whereas active electrodes are easier to use but limited by increased height and larger decay artifacts. Here we introduce an ultra-thin active electrode system combined with hardware- and software-based artifact suppression. We collected electroencephalographic data from 10 healthy adults in Austria in 2024, recording brain responses with both active and passive electrodes during stimulation of the left primary motor cortex. We analyzed early and late responses for similarity and amplitude variability and found high consistency between electrode types, with stable waveforms after 20-30 trials. Response amplitudes did not differ significantly between electrode types. These findings demonstrate that active electrode systems can provide reliable and efficient recordings, supporting their broader use in stimulation-electroencephalography research.

经颅磁刺激结合脑电图可以通过刺激诱发反应直接评估皮层的兴奋性和连通性。虽然无源电极仍然是金标准,但它们需要大量的准备,并且对接触质量敏感,而有源电极更容易使用,但受到高度增加和更大的衰减伪影的限制。本文介绍了一种结合硬件和软件抑制伪影的超薄有源电极系统。我们于2024年在奥地利收集了10名健康成年人的脑电图数据,记录了在刺激左初级运动皮层时大脑的主动和被动电极反应。我们分析了早期和晚期响应的相似性和幅度可变性,发现电极类型之间具有高度一致性,经过20-30次试验后波形稳定。不同电极类型的反应幅度无显著差异。这些发现表明,有源电极系统可以提供可靠和有效的记录,支持其在刺激脑电图研究中的广泛应用。
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引用次数: 0
Object detection as an aid for locating the prostate in surface-based abdominal ultrasound images. 在基于表面的腹部超声图像中,目标检测作为定位前列腺的辅助。
Pub Date : 2025-11-28 DOI: 10.1038/s44172-025-00550-y
Rory D Bennett, Tristan Barrett, Vincent J Gnanapragasam, Zion Tsz Ho Tse

Automatic object detection is increasingly used in the medical field to enhance clinical workflows before, during, and after diagnosis of various conditions. One example is prostate detection and prostate volume estimation, which can aid in triaging patients for prostate cancer through risk-stratification using prostate-specific antigen density. In this paper, a baseline prostate detection framework is presented, highlighting that current state-of-the-art object detection models can detect the prostate in difficult to interpret surface-based ultrasound images. A 5-fold cross-validation study returned intersection-over-union, precision, recall, F1, and average-precision values above 0.7 with real-time capabilities possible. Additionally, a simple size calculation based on the detection results showed high correlation with ground truth measurements, with Pearson Correlation Coefficients ranging from 0.55 to 0.84 for prostate volume estimates. These findings will contribute to the development of a real-time prostate detection and size estimation platform for prostate cancer risk-stratification to reduce unnecessary biopsy rates in healthcare systems.

自动目标检测越来越多地应用于医疗领域,以增强各种疾病诊断之前,期间和之后的临床工作流程。一个例子是前列腺检测和前列腺体积估计,它可以通过使用前列腺特异性抗原密度进行风险分层来帮助诊断前列腺癌患者。本文提出了一个基线前列腺检测框架,强调当前最先进的目标检测模型可以在难以解释的基于表面的超声图像中检测前列腺。一项5倍交叉验证研究返回的交叉-超联合、精度、召回率、F1和平均精度值都在0.7以上,并且可能具有实时功能。此外,基于检测结果的简单大小计算显示与基础真值测量高度相关,前列腺体积估计值的Pearson相关系数范围为0.55至0.84。这些发现将有助于开发前列腺癌风险分层的实时前列腺检测和大小估计平台,以减少医疗保健系统中不必要的活检率。
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引用次数: 0
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Communications engineering
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