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Moderated mediation model of subjective happiness and gender between financial strain and mental health of university students. 大学生经济压力与心理健康的主观幸福感、性别调节中介模型
IF 2.7 Pub Date : 2025-11-27 DOI: 10.1007/s44192-025-00338-8
Dare Azeez Fagbenro, Helen Foluke Olagundoye, Leepile Alfred Sehularo, Adeola Baseerat Lawal, Jackson Iheukwumere Osuh

Background: Previous findings have established a negative association between financial strain and mental health, although this kind of investigation among Nigerian university students is relatively scarce. However, the mechanism as well as the conditions among the associations have not received sufficient research attention in the literature. Therefore, this study investigated the link between financial strain and mental health as well as the mediating effect of subjective happiness in the association between financial strain and mental health among university students. The study also explored the moderated mediated role of gender in the relationship.

Methods: This cross-sectional study used self-report measures of the Mental Health Scale, Financial Strain Scale, and Subjective Happiness Scale for data collection. A total of 196 university students aged 18-29 (female = 51.5%; mean age = 21.11 ± 1.64 years) participated in the study. Data were analysed with the Pearson Product Moment Correlation (PPMC) and Hayes PROCESS macro statistical tools.

Results: A negative predictive association was linked with financial strain and mental health among university students. Further, subjective happiness was found to statistically mediate the link between financial strain and mental health. Also, gender did not have conditional indirect effect on subjective happiness on mental health through subjective happiness.

Conclusion: The study concluded that financial strain negatively linked with mental health and subjective happiness was associated with a mediation pattern between financial strain and mental health with no moderating effect in the association. Intervention policies aimed at reducing financial strain as well as student's wellbeing programs aimed at improving positive affect among university students should be tailored toward enhancing students' mental health.

背景:以往的研究结果已经建立了经济压力与心理健康之间的负相关关系,尽管在尼日利亚大学生中进行的此类调查相对较少。然而,相关文献对其作用机制及相关条件的研究还不够重视。因此,本研究旨在探讨大学生经济压力与心理健康的关系,以及主观幸福感在大学生经济压力与心理健康关系中的中介作用。研究还探讨了性别在关系中的调节中介作用。方法:本横断面研究采用心理健康量表、财务压力量表和主观幸福感量表的自我报告测量来收集数据。共有196名18-29岁的大学生参与研究,其中女性占51.5%,平均年龄为21.11±1.64岁。使用Pearson积差相关(PPMC)和Hayes PROCESS宏观统计工具对数据进行分析。结果:大学生经济压力与心理健康呈负向预测相关。此外,主观幸福感被发现在统计上调解财务压力和心理健康之间的联系。性别对主观幸福感不存在有条件的间接影响,通过主观幸福感影响心理健康。结论:财务压力与心理健康和主观幸福感呈负相关,在财务压力与心理健康之间存在中介关系,且无调节作用。旨在减轻经济压力的干预政策,以及旨在提高大学生积极影响的学生福利计划,都应该针对提高学生的心理健康而量身定制。
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引用次数: 0
Examining the role of social support in imposter phenomenon among medical students through mediation and moderation analysis of anxiety and stress. 透过焦虑与压力的中介与调节分析,检视社会支持在医学生冒名顶替现象中的作用。
IF 2.7 Pub Date : 2025-11-27 DOI: 10.1007/s44192-025-00347-7
Maryam Fatima, Manahil Qamar, Hira Irfan, Hurais Malik, Faraheem Batool, Jawaria Shahzad, Muhammad Shoaib Alam, Muhammad Usama Jamil, Alishba Jamil, Sumaira Mohiuddin, Muhammad Abdullah, Zuhair Ahmed, Abdul Rehman, Ayat Ul Karam, Usaid Malik, Khabab Abbasher Hussien Mohamed Ahmed
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引用次数: 0
Predictors of psychological distress among postpartum women at a tertiary health institution in Nigeria. 尼日利亚某三级保健机构产后妇女心理困扰的预测因素。
IF 2.7 Pub Date : 2025-11-26 DOI: 10.1007/s44192-025-00345-9
Cecilia Bukola Bello, Oyindamola Mariam Raji, Mumini Idowu Adarabioyo, Risikat Idowu Fadare, Olawale Ignatius Oni, Ayodeji Fasoro

Objective: To assess psychological distress and its predictors among postpartum women at a tertiary health institution.

Methods: We adopted an analytical cross-sectional design. We recruited 195 postpartum women using a purposive sampling technique. A structured paper questionnaire adapted from previous studies was used. We assessed psychological distress using the Kessler Psychological Distress Scale (K10). The predictors of psychological distress were determined using multivariable binary logistic regression. The level of significance was set at 0.05.

Results: The overall mean score was 18.96 ± 6.48 from a total obtainable score of 50 from the K10 scale. Fifty-one (26.2%) reported a high level of psychological distress. Young age (AOR = 2.132, 95% CI 1.659-5.935), a low education level (AOR = 3.362, 95% CI 1.822-4.873), multiparity (AOR = 2.431, 95% CI 1.581-7.755), previous history of abortion (AOR = 3.530, 95% CI 2.474-5.060), pre-pregnancy alcohol use (AOR = 3.167, 95% CI 1.265-7.786), and intimate partner violence (AOR = 5.493, 95% CI 3.410-7.142) were significant predictors of postpartum psychological distress.

Conclusion: Our study finds a high prevalence of psychological distress among postpartum women and recommends that targeted screening and interventions should be developed to provide support and treatment for pregnant and postpartum women identified with psychological distress.

目的:评价某三级医疗机构产后妇女的心理困扰及其预测因素。方法:采用分析性横断面设计。我们采用有目的的抽样技术招募了195名产后妇女。采用了先前研究的结构化纸质问卷。我们使用Kessler心理困扰量表(K10)评估心理困扰。采用多变量二元逻辑回归确定心理困扰的预测因素。显著性水平设为0.05。结果:K10量表总分50分,总平均得分为18.96±6.48分。51人(26.2%)报告了高度的心理困扰。年龄小(AOR = 2.132, 95% CI 1.659-5.935)、受教育程度低(AOR = 3.362, 95% CI 1.822-4.873)、多胎(AOR = 2.431, 95% CI 1.581-7.755)、流产史(AOR = 3.530, 95% CI 2.474-5.060)、孕前饮酒(AOR = 3.167, 95% CI 1.265-7.786)、亲密伴侣暴力(AOR = 5.493, 95% CI 3.41 -7.142)是产后心理困扰的重要预测因素。结论:本研究发现产后妇女心理困扰发生率较高,建议制定有针对性的筛查和干预措施,为有心理困扰的孕妇和产后妇女提供支持和治疗。
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引用次数: 0
Psychiatrists' opinions about non-medicalization of cannabis use disorder in Iran. 精神科医生对伊朗大麻使用障碍非医学化的看法。
IF 2.7 Pub Date : 2025-11-26 DOI: 10.1007/s44192-025-00326-y
Hamidreza Namazi, Mehdi Sayyah

Background: Cannabis Use Disorder (CUD) is a significant challenge in public health and treatment policy. While medicalization has facilitated greater access to treatment services, it may also lead to dependency on pharmacological treatments and increased unnecessary healthcare costs. This study aimed to explore psychiatrists' perspectives on the demedicalization of CUD.

Methods: This qualitative study employed a phenomenological approach and was conducted in Iran. Data were collected through in-depth semi-structured interviews with 16 psychiatrists experienced in the field of addiction. The qualitative data were analyzed using inductive content analysis, by the Graneheim and Lundman approach.

Results: Four main themes obtained from the interviews: "Advantages of Demedicalization", "Disadvantages of Demedicalization", "Social and Cultural Impacts", and "Policy Making and Suggested Interventions". Key perceived benefits included reducing social stigma, enhancing patient empowerment, reducing dependency on pharmacological treatments, and addressing the socio-economic and psychological roots of cannabis use. The main reported disadvantages included increasing treatment challenges and exacerbation of social damages. Regarding sociocultural effects, participants emphasized improved social interactions and changes in cultural attitudes. In terms of policy making and interventions, the psychiatrists recommended modifying legal approaches, adopting a comprehensive and multifaceted treatment model, and preventing the dangerous normalization of cannabis use.

Conclusion: The psychiatrists emphasized that the demedicalization of CUD could offer potential benefits, such as reducing social stigma and improving social acceptance, while they also highlighted some potential risks. These insights may inform future policies and practices regarding CUD.

背景:大麻使用障碍(CUD)是公共卫生和治疗政策中的一个重大挑战。虽然医疗化促进了更多获得治疗服务的机会,但它也可能导致对药物治疗的依赖,并增加不必要的医疗费用。本研究旨在探讨精神病学家对CUD去医学化的看法。方法:本定性研究采用现象学方法,并在伊朗进行。数据是通过与16位在成瘾领域有经验的精神病学家进行深入的半结构化访谈收集的。定性数据采用Graneheim和Lundman方法进行归纳内容分析。结果:从访谈中获得四个主要主题:“去医疗化的优势”、“去医疗化的劣势”、“社会和文化影响”以及“政策制定和建议干预”。可感知的主要益处包括减少社会耻辱感、增强患者权能、减少对药物治疗的依赖,以及解决大麻使用的社会经济和心理根源。报告的主要缺点包括治疗挑战增加和社会损害加剧。关于社会文化影响,与会者强调社会互动的改善和文化态度的改变。在政策制定和干预方面,精神科医生建议修改法律途径,采用全面和多方面的治疗模式,防止大麻使用正常化的危险。结论:精神科医生强调CUD的去医学化可以提供潜在的好处,如减少社会耻辱感和提高社会接受度,但他们也强调了一些潜在的风险。这些见解可以为未来关于CUD的政策和实践提供信息。
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引用次数: 0
Depression and associated factors among patients with common eye diseases at the University of Gondar Comprehensive and Specialized Hospital Northwest Ethiopia. 埃塞俄比亚西北部贡达尔大学综合专科医院常见眼病患者的抑郁及相关因素
IF 2.7 Pub Date : 2025-11-25 DOI: 10.1007/s44192-025-00320-4
Marye Asfaw, Tilahun Kassew, Senait Tadele, Setegn Fentahun, Fantahun Andualem

Background: Depression is a common mental illness that negatively affects quality of life and is often comorbid with chronic medical conditions. Limited evidence exists on its burden among patients with eye diseases. This study aimed to assess the prevalence of depression in patients with eye diseases and explore contributing factors, highlighting the link between depression and ocular conditions.

Methods: An institutional-based cross-sectional study was conducted from March 24 to April 24, 2023, at the Tertiary Eye Clinic of the University of Gondar Comprehensive and Specialized Hospital. A systematic random sample of 561 participants was recruited, and 557 completed the survey (99.3% response rate). Depression was measured using the Patient Health Questionnaire-9. Bivariate and multivariable logistic regression analyses were performed, with statistical significance set at p < 0.05.

Result: The prevalence of depression was 44.3% (95% CI: 40.3-48.5%). Factors significantly associated with depression included being widowed, poor social support, severe visual impairment, treatment duration > 4 years, diabetes mellitus, and current alcohol use.

Conclusion: Depression was highly prevalent among patients with eye diseases in this setting. Routine screening and psychosocial support should be integrated into ophthalmic care to improve patient outcomes.

背景:抑郁症是一种常见的精神疾病,对生活质量产生负面影响,通常与慢性疾病合并症。有关其在眼病患者中的负担的证据有限。本研究旨在评估眼部疾病患者抑郁症的患病率,并探讨影响因素,强调抑郁症与眼部疾病之间的联系。方法:于2023年3月24日至4月24日在贡达尔大学综合专科医院第三眼科门诊进行了一项以机构为基础的横断面研究。系统随机抽样561人,完成调查557人,回复率99.3%。抑郁症采用患者健康问卷-9进行测量。结果:抑郁症患病率为44.3% (95% CI: 40.3 ~ 48.5%)。与抑郁症显著相关的因素包括丧偶、缺乏社会支持、严重的视力损害、治疗持续时间40 ~ 40年、糖尿病和当前饮酒。结论:该地区眼病患者抑郁发生率较高。常规筛查和社会心理支持应纳入眼科护理,以改善患者的预后。
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引用次数: 0
Usability evaluation of a mobile mental health app for depression and anxiety self-care in Ethiopia. 埃塞俄比亚用于抑郁和焦虑自我护理的移动心理健康应用程序的可用性评估。
IF 2.7 Pub Date : 2025-11-25 DOI: 10.1007/s44192-025-00315-1
Yonas Deressa Guracho, Susan J Thomas, Khin Than Win

Introduction: Mobile mental health apps provide a potential solution by offering tailored access to resources for mental health education, self-assessment, and self-care. However, mental health apps designed for the Ethiopian setting are scarce; therefore, this study assesses the usability and user experience of a locally adapted app addressing depression and anxiety.

Objective: To determine the usability of a newly developed 'Mental Health Solution App' among individuals with depression and anxiety in Ethiopia.

Methods: A convergent mixed-methods design was used to evaluate the usability and user experience of a culturally adapted version of the 'Mental Health Solution App' in Ethiopia. The study was conducted at Tibebe Ghion Specialized Hospital, and Amanuel Mental Specialized Hospital from January 10 to February 20, 2025. The quantitative strand involved a cross-sectional survey using the Amharic version of the Mobile App Usability Questionnaire (MAUQ) (n = 370). The qualitative strand comprised in-depth interviews (n = 20) analyzed via reflexive thematic analysis, guided by Braun and Clarke's six-step framework. This design enabled triangulation of usability metrics with user narratives, offering a comprehensive understanding of app functionality, engagement, and contextual relevance.

Results: The survey involved 370 participants. Of these, 158 suffered from major depressive disorders, while 212 suffered from anxiety disorders. Usability testing of the Amharic 'Mental Health Solution App' showed high satisfaction, a mean score above 6.18 on a 7-point scale across ease of use (6.18 to 6.43), interface satisfaction (6.38-6.60), and usefulness (6.31-6.71). Four themes were identified (user experience, feature liking, benefit, and suggestions).

Conclusion: The Mental Health Solution App's usability in terms of ease of use, interface satisfaction, and usefulness was deemed very good. Mood tracking and crisis support were the app's most preferred features. However, it can be challenging to navigate emergency first aid during moments of distress. The findings indicate that a customized app designed for Ethiopian culture and language could help individuals suffering from depression and anxiety within an educated, urban cohort receiving mental health care in Ethiopia.

Clinical trial number: Not applicable (it is an app usability test).

导读:移动心理健康应用程序提供了一种潜在的解决方案,通过提供量身定制的访问资源进行心理健康教育、自我评估和自我保健。然而,为埃塞俄比亚环境设计的心理健康应用程序很少;因此,本研究评估了一款针对抑郁和焦虑的本地应用程序的可用性和用户体验。目的:确定埃塞俄比亚新开发的“心理健康解决方案应用程序”在抑郁症和焦虑症患者中的可用性。方法:采用融合混合方法设计来评估埃塞俄比亚“心理健康解决方案应用程序”的文化适应版本的可用性和用户体验。该研究于2025年1月10日至2月20日在Tibebe Ghion专科医院和Amanuel精神专科医院进行。定量链包括使用阿姆哈拉语版本的手机应用可用性问卷(MAUQ)进行横断面调查(n = 370)。定性链包括深度访谈(n = 20),在Braun和Clarke的六步框架的指导下,通过反思性主题分析进行分析。这种设计能够将可用性指标与用户叙述进行三角测量,提供对应用功能、用户粘性和上下文相关性的全面理解。结果:该调查涉及370名参与者。其中,158人患有重度抑郁症,212人患有焦虑症。阿姆哈拉语“心理健康解决方案应用程序”的可用性测试显示出很高的满意度,在易用性(6.18至6.43)、界面满意度(6.38至6.60)和实用性(6.31至6.71)的7分制中,平均得分超过6.18分。确定了四个主题(用户体验、特性喜好、好处和建议)。结论:心理健康解决方案App的易用性、界面满意度和实用性均较好。情绪追踪和危机支持是这款应用最受欢迎的功能。然而,在遇险时刻进行紧急急救可能是一项挑战。研究结果表明,为埃塞俄比亚文化和语言设计的定制应用程序可以帮助受过教育的埃塞俄比亚城市人群中患有抑郁症和焦虑症的人接受精神卫生保健。临床试验号:不适用(这是一个应用可用性测试)。
{"title":"Usability evaluation of a mobile mental health app for depression and anxiety self-care in Ethiopia.","authors":"Yonas Deressa Guracho, Susan J Thomas, Khin Than Win","doi":"10.1007/s44192-025-00315-1","DOIUrl":"10.1007/s44192-025-00315-1","url":null,"abstract":"<p><strong>Introduction: </strong>Mobile mental health apps provide a potential solution by offering tailored access to resources for mental health education, self-assessment, and self-care. However, mental health apps designed for the Ethiopian setting are scarce; therefore, this study assesses the usability and user experience of a locally adapted app addressing depression and anxiety.</p><p><strong>Objective: </strong>To determine the usability of a newly developed 'Mental Health Solution App' among individuals with depression and anxiety in Ethiopia.</p><p><strong>Methods: </strong>A convergent mixed-methods design was used to evaluate the usability and user experience of a culturally adapted version of the 'Mental Health Solution App' in Ethiopia. The study was conducted at Tibebe Ghion Specialized Hospital, and Amanuel Mental Specialized Hospital from January 10 to February 20, 2025. The quantitative strand involved a cross-sectional survey using the Amharic version of the Mobile App Usability Questionnaire (MAUQ) (n = 370). The qualitative strand comprised in-depth interviews (n = 20) analyzed via reflexive thematic analysis, guided by Braun and Clarke's six-step framework. This design enabled triangulation of usability metrics with user narratives, offering a comprehensive understanding of app functionality, engagement, and contextual relevance.</p><p><strong>Results: </strong>The survey involved 370 participants. Of these, 158 suffered from major depressive disorders, while 212 suffered from anxiety disorders. Usability testing of the Amharic 'Mental Health Solution App' showed high satisfaction, a mean score above 6.18 on a 7-point scale across ease of use (6.18 to 6.43), interface satisfaction (6.38-6.60), and usefulness (6.31-6.71). Four themes were identified (user experience, feature liking, benefit, and suggestions).</p><p><strong>Conclusion: </strong>The Mental Health Solution App's usability in terms of ease of use, interface satisfaction, and usefulness was deemed very good. Mood tracking and crisis support were the app's most preferred features. However, it can be challenging to navigate emergency first aid during moments of distress. The findings indicate that a customized app designed for Ethiopian culture and language could help individuals suffering from depression and anxiety within an educated, urban cohort receiving mental health care in Ethiopia.</p><p><strong>Clinical trial number: </strong>Not applicable (it is an app usability test).</p>","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":"205"},"PeriodicalIF":2.7,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12748418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lived experiences of adolescents and young adults receiving inpatient psychiatric care. 青少年和年轻人接受住院精神病治疗的生活经历。
IF 2.7 Pub Date : 2025-11-25 DOI: 10.1007/s44192-025-00279-2
Aaron Nwedu, Jude Ominyi, David Agom

Background: Adolescents and young adults in low-and middle-income countries (LMICs), face multiple barriers to accessing quality mental health care, shaped by cultural expectations, systemic gaps, and widespread stigma. In Nigeria, little is known about how these factors intersect within psychiatric inpatient settings. This study explored the lived experiences of adolescents and young adults receiving inpatient psychiatric care to inform more culturally responsive, family-engaged, and psychologically supportive models of care.

Methods: Using an Interpretative Phenomenological Approach, we conducted in-depth semi-structured interviews with 28 participants aged 13 to 28 years, all receiving care at a public psychiatric hospital in South-Eastern Nigeria. Participants were purposively sampled and represented a range of diagnostic categories. The hospital, serving a diverse catchment area, reflects a hybrid system of biomedical and traditional models of care. Interviews were conducted over nine months and analysed through iterative, reflexive engagement, supported by member checking to enhance credibility and contextual grounding.

Results: Participants described a range of emotionally charged experiences, with stigma emerging as a major theme. Several reported social withdrawal, strained family dynamics, and shifts in how they were perceived by others. Relationships with peers in hospital varied, offering both connection and tension. Personal coping strategies, such as prayer, art, music, and peer dialogue were commonly described. Despite these efforts, many expressed a desire for consistent psychological support and greater engagement from staff. Hospital environments were viewed as both protective and limiting, with concerns raised about overcrowding, lack of privacy, and emotional neglect.

Conclusion: While the findings cannot be generalised, they offer important insights into the mental health journeys of young people within a Nigerian inpatient setting. Participants called for greater emotional and relational support, staff communication, and culturally sensitive care. These perspectives highlight areas for further research and service improvement in youth mental health provision across similar contexts.

背景:低收入和中等收入国家(LMICs)的青少年和青壮年在获得高质量精神卫生保健方面面临多重障碍,这些障碍是由文化期望、系统性差距和普遍的耻辱感造成的。在尼日利亚,人们对这些因素如何在精神病住院环境中相互影响知之甚少。本研究探讨了青少年和年轻人接受住院精神病治疗的生活经历,以提供更多文化响应,家庭参与和心理支持的护理模式。方法:采用解释现象学方法,我们对28名年龄在13至28岁之间的参与者进行了深入的半结构化访谈,这些参与者都在尼日利亚东南部的一家公立精神病院接受治疗。参与者被有意取样,并代表了一系列的诊断类别。该医院服务于一个多样化的集水区,反映了生物医学和传统护理模式的混合系统。访谈进行了九个多月,并通过反复的、反身性的参与进行分析,并辅以成员核查,以提高可信度和背景基础。结果:参与者描述了一系列充满情绪的经历,其中耻辱感是一个主要主题。一些人报告了社交退缩,家庭关系紧张,以及他人对他们的看法发生了变化。在医院里与同伴的关系各不相同,既有联系,也有紧张。个人应对策略,如祈祷、艺术、音乐和同伴对话,通常被描述。尽管作出了这些努力,但许多人表示希望得到一贯的心理支持和工作人员更多的参与。医院环境被视为既保护又限制,人们对过度拥挤、缺乏隐私和情感忽视提出了担忧。结论:虽然这些发现不能一概推广,但它们为尼日利亚住院环境中年轻人的心理健康之旅提供了重要的见解。与会者呼吁加强情感和关系方面的支持,加强工作人员的沟通,以及对文化敏感的护理。这些观点强调了在类似背景下进一步研究和改善青少年心理健康服务的领域。
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引用次数: 0
An overview of oxytocin integrative mechanisms in autism spectrum disorder. 自闭症谱系障碍中催产素整合机制综述。
IF 2.7 Pub Date : 2025-11-25 DOI: 10.1007/s44192-025-00331-1
Nand Lal, Bin Song, Chi Zhang, Wadee Abdullah Al-Shehari, Sadia Jabeen, Niaz Ahmed, Wadhah Hassan Edrees, Radheshyam Gupta, Samiullah Soomro, Feiyun Cui, Eglal Ahmed Qasem

Autism Spectrum Disorder (ASD) is a multifaceted neurodevelopmental condition characterized by impairments in social interaction, communication, and repetitive behaviors. Its etiology involves a complex interplay of genetic, environmental, and neurobiological factors. The oxytocin (OT) system, central to social behavior and emotional regulation, has emerged as a key area of interest in ASD research. This review synthesizes current evidence, highlighting that dysregulation of OT and its receptor (OTR) signaling, often characterized by lower baseline OT levels and altered OTR expression due to genetic and epigenetic factors, contributes to the social and behavioral deficits observed in ASD. While aberrant OT/OTR signaling presents a potential target for therapeutic intervention, the narrative has evolved beyond simple peptide replacement. Critical analysis reveals that intranasal OT administration, as a standalone treatment, yields inconsistent results due to its non-specific delivery and inability to address core circuit-level dysfunctions established during neurodevelopment. Promising future avenues include the development of selective OTR agonists, epigenetic modulation to correct OTR expression, and the use of OT as a targeted adjunct to enhance behavioral therapy efficacy. This paper provides a comprehensive and critical overview of the integrative mechanisms linking OT/OTR signaling to ASD, evaluates the therapeutic potential of correcting this pathway, and emphasizes the necessity for personalized, biomarker-driven approaches to improve social cognition and neural connectivity in individuals with ASD.

自闭症谱系障碍(ASD)是一种多方面的神经发育疾病,其特征是社会互动、沟通和重复行为的障碍。其病因涉及遗传、环境和神经生物学因素的复杂相互作用。催产素(OT)系统是社会行为和情绪调节的核心,已成为ASD研究的一个关键领域。这篇综述综合了目前的证据,强调了OT及其受体(OTR)信号的失调,通常以较低的基线OT水平和由于遗传和表观遗传因素导致的OTR表达改变为特征,是ASD中观察到的社会和行为缺陷的原因。虽然异常的OT/OTR信号为治疗干预提供了潜在的目标,但其叙事已经超越了简单的肽替代。关键分析表明,鼻内OT作为一种独立的治疗方法,由于其非特异性递送和无法解决神经发育过程中建立的核心回路水平的功能障碍,产生了不一致的结果。有希望的未来途径包括选择性OTR激动剂的开发,表观遗传调节来纠正OTR表达,以及使用OT作为靶向辅助来提高行为治疗的疗效。本文对连接OT/OTR信号与ASD的综合机制进行了全面和批判性的概述,评估了纠正这一途径的治疗潜力,并强调了个性化、生物标志物驱动的方法改善ASD患者社会认知和神经连通性的必要性。
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引用次数: 0
Diabetes distress among adults with type 2 diabetes mellitus in the North of West Bank-Palestine. 西岸-巴勒斯坦北部成人2型糖尿病患者的糖尿病困扰
IF 2.7 Pub Date : 2025-11-25 DOI: 10.1007/s44192-025-00304-4
Ibrahim Ghoul, Mohammed F Hayek, Yousef Ahwal, Shahd Abdalghani, Yazeed Abo Baker, Malak Abed Aljwad, Eman Alshawish, Mohamed Kbalan, Abdullah Abdullah, Nizar B Said, Aidah Alkaissi, Murad Jkhlab

Background: Diabetes distress, the emotional burden and stress related to managing type 2 diabetes mellitus, has been linked to poor self-management and adverse health outcomes. In Palestine, particularly in the North of West Bank, adults with type 2 diabetes mellitus face unique social and economic challenges that may exacerbate diabetes distress, impacting their ability to maintain effective diabetes management. Addressing diabetes distress is crucial for improving health outcomes and quality of life in this population, yet research on its prevalence and associated factors in the North of West Bank is limited. This study aimed to assess the prevalence of diabetes distress and identify its associated demographic, socioeconomic, and clinical factors among adults with type 2 diabetes mellitus in the North of West Bank, Palestine.

Methodology: A cross-sectional study was conducted with 404 adults diagnosed with type 2 diabetes mellitus in various healthcare centers across the North of West Bank. Participants completed the Diabetes Distress Scale-17 and a sociodemographic questionnaire, and additional clinical data such as HbA1c levels. Descriptive and inferential statistics were employed to identify associations between diabetes distress and demographic, socioeconomic, and clinical factors, with a focus on assessing the impact of these variables on distress levels.

Results: Of the 423 eligible individuals approached, 404 participants were included in the final analysis (response rate: 95.5%). The median age was 55 years (IQR: 49-63), with a nearly equal gender distribution. Poor glycemic control (HbA1c > 6.4%) was observed in 76.0% of participants, and 74.3% reported one or more comorbidities. High and moderate levels of diabetic distress were reported by 29.0% and 25.2% of participants, respectively, with emotional and regimen-related distress being the most prevalent domains. Significant factors associated with higher distress included comorbidities, smoking, urban residence, unemployment, living with family, and residence in Nablus. Multinomial logistic regression revealed that absence of comorbidities, younger age, living alone, and non-urban residence were protective factors against high distress (p < .05). The model explained 20.1% of the variance in distress levels (Nagelkerke R² = 0.201).

Conclusion: Diabetes distress is common among adults with type 2 diabetes and is significantly influenced by clinical, sociodemographic, and lifestyle factors. Routine screening and targeted psychosocial interventions are essential, especially for high-risk groups, to improve both psychological well-being and diabetes outcomes.

背景:糖尿病困扰,与2型糖尿病管理相关的情绪负担和压力,与不良的自我管理和不良的健康结果有关。在巴勒斯坦,特别是在西岸北部,患有2型糖尿病的成年人面临着独特的社会和经济挑战,这些挑战可能加剧糖尿病的痛苦,影响他们维持有效糖尿病管理的能力。解决糖尿病困扰对于改善这一人群的健康结果和生活质量至关重要,但对西岸北部地区糖尿病患病率和相关因素的研究有限。本研究旨在评估巴勒斯坦西岸北部成人2型糖尿病患者糖尿病窘迫的患病率,并确定其相关的人口统计学、社会经济和临床因素。方法:对西岸北部各医疗中心诊断为2型糖尿病的404名成年人进行了横断面研究。参与者完成了糖尿病困扰量表-17和社会人口调查问卷,以及额外的临床数据,如HbA1c水平。采用描述性和推断性统计来确定糖尿病痛苦与人口统计学、社会经济和临床因素之间的关联,重点评估这些变量对痛苦水平的影响。结果:在423名符合条件的个体中,404名参与者被纳入最终分析(应答率:95.5%)。中位年龄为55岁(IQR: 49-63),性别分布几乎相等。76.0%的参与者血糖控制不良(HbA1c bb0 6.4%), 74.3%的参与者报告了一种或多种合并症。分别有29.0%和25.2%的参与者报告了高水平和中等水平的糖尿病痛苦,其中情绪和方案相关的痛苦是最普遍的领域。与高痛苦相关的重要因素包括合并症、吸烟、城市居住、失业、与家人同住以及居住在纳布卢斯。多项logistic回归分析显示,无合并症、年龄小、独居和非城市居住是2型糖尿病患者高焦虑的保护因素(p)。结论:糖尿病焦虑在2型糖尿病成人患者中普遍存在,并受临床、社会人口学和生活方式等因素的显著影响。常规筛查和有针对性的社会心理干预对于改善心理健康和糖尿病结局至关重要,特别是对高危人群而言。
{"title":"Diabetes distress among adults with type 2 diabetes mellitus in the North of West Bank-Palestine.","authors":"Ibrahim Ghoul, Mohammed F Hayek, Yousef Ahwal, Shahd Abdalghani, Yazeed Abo Baker, Malak Abed Aljwad, Eman Alshawish, Mohamed Kbalan, Abdullah Abdullah, Nizar B Said, Aidah Alkaissi, Murad Jkhlab","doi":"10.1007/s44192-025-00304-4","DOIUrl":"10.1007/s44192-025-00304-4","url":null,"abstract":"<p><strong>Background: </strong>Diabetes distress, the emotional burden and stress related to managing type 2 diabetes mellitus, has been linked to poor self-management and adverse health outcomes. In Palestine, particularly in the North of West Bank, adults with type 2 diabetes mellitus face unique social and economic challenges that may exacerbate diabetes distress, impacting their ability to maintain effective diabetes management. Addressing diabetes distress is crucial for improving health outcomes and quality of life in this population, yet research on its prevalence and associated factors in the North of West Bank is limited. This study aimed to assess the prevalence of diabetes distress and identify its associated demographic, socioeconomic, and clinical factors among adults with type 2 diabetes mellitus in the North of West Bank, Palestine.</p><p><strong>Methodology: </strong>A cross-sectional study was conducted with 404 adults diagnosed with type 2 diabetes mellitus in various healthcare centers across the North of West Bank. Participants completed the Diabetes Distress Scale-17 and a sociodemographic questionnaire, and additional clinical data such as HbA1c levels. Descriptive and inferential statistics were employed to identify associations between diabetes distress and demographic, socioeconomic, and clinical factors, with a focus on assessing the impact of these variables on distress levels.</p><p><strong>Results: </strong>Of the 423 eligible individuals approached, 404 participants were included in the final analysis (response rate: 95.5%). The median age was 55 years (IQR: 49-63), with a nearly equal gender distribution. Poor glycemic control (HbA1c > 6.4%) was observed in 76.0% of participants, and 74.3% reported one or more comorbidities. High and moderate levels of diabetic distress were reported by 29.0% and 25.2% of participants, respectively, with emotional and regimen-related distress being the most prevalent domains. Significant factors associated with higher distress included comorbidities, smoking, urban residence, unemployment, living with family, and residence in Nablus. Multinomial logistic regression revealed that absence of comorbidities, younger age, living alone, and non-urban residence were protective factors against high distress (p < .05). The model explained 20.1% of the variance in distress levels (Nagelkerke R² = 0.201).</p><p><strong>Conclusion: </strong>Diabetes distress is common among adults with type 2 diabetes and is significantly influenced by clinical, sociodemographic, and lifestyle factors. Routine screening and targeted psychosocial interventions are essential, especially for high-risk groups, to improve both psychological well-being and diabetes outcomes.</p>","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":"1"},"PeriodicalIF":2.7,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12764720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross-sectional study of the association between pain and depression in patients with brachial plexopathy. 臂丛病患者疼痛与抑郁关系的横断面研究。
IF 2.7 Pub Date : 2025-11-24 DOI: 10.1007/s44192-025-00322-2
Erik Michael Tito-Huaraqui, Larissa Silveira-Machado, Salomon Huancahuire-Vega, David R Soriano-Moreno
{"title":"Cross-sectional study of the association between pain and depression in patients with brachial plexopathy.","authors":"Erik Michael Tito-Huaraqui, Larissa Silveira-Machado, Salomon Huancahuire-Vega, David R Soriano-Moreno","doi":"10.1007/s44192-025-00322-2","DOIUrl":"10.1007/s44192-025-00322-2","url":null,"abstract":"","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":"5 1","pages":"183"},"PeriodicalIF":2.7,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12644275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145589959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Discover mental health
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