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Validation of a reduced version of the child and youth resilience measure (CYRM-28) for public health use in Aotearoa New Zealand. 新西兰奥特罗阿公共卫生使用儿童和青年复原力测量(CYRM-28)简化版本的验证。
IF 2.7 Pub Date : 2025-12-29 DOI: 10.1007/s44192-025-00325-z
Linda Liebenberg, Jackie Sanders, Jayne Mercier

Globally, there is increasing need to address the burden of mental illness on populations, including youth, and increasing recognition of the role of social determinants on mental health. The study of resilience, as an ecological process of individual and community resource mobilisation in the face of adversity, is a promising lens through which to understand culturally and contextually relevant factors that enhance or inhibit mental wellbeing. This paper reports on a validation of a reduced, 2-factor, 17-item form of the child and youth resilience measure (CYRM-28) on a population of youth in Aotearoa (New Zealand) who were involved in multiple service systems, including child and adolescent mental health services. It builds on previous work which validated the full 28-item scale. It responds to needs articulated by researchers and service providers for a shortened version of the CYRM-28 that reduces assessment burdens on youth and clinicians. The reduced form may be helpful in mental health settings to quickly understand the resilience resources around vulnerable youth and support interventions that build on strengths and directly address areas where resources are missing.

在全球范围内,越来越需要解决包括青年在内的人口的精神疾病负担,并日益认识到社会决定因素对精神卫生的作用。弹性的研究,作为一个面对逆境的个人和社区资源动员的生态过程,是一个有希望的镜头,通过它来理解文化和背景相关的因素,增强或抑制心理健康。本文报告了在新西兰奥特罗阿(Aotearoa)参与多种服务系统(包括儿童和青少年心理健康服务)的青少年群体中,对减少的,2因素,17项形式的儿童和青少年弹性测量(CYRM-28)进行验证。它建立在先前的工作基础上,该工作验证了完整的28项量表。它响应了研究人员和服务提供者对缩短版CYRM-28的需求,减少了青年和临床医生的评估负担。简化后的表格可能有助于在心理健康环境中迅速了解脆弱青年周围的复原力资源,并支持以优势为基础的干预措施,并直接解决资源缺失的领域。
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引用次数: 0
A national study of sex and mental health considerations among provincial and territorial correctional workers in Canada. 关于加拿大省和地区惩教工作者的性和心理健康考虑的全国性研究。
IF 2.7 Pub Date : 2025-12-28 DOI: 10.1007/s44192-025-00361-9
Matthew S Johnston, Rosemary Ricciardelli, Marina Carbonell, Sahar Dorniani, Tamara L Taillieu, Seamus Keiley, Tracie O Afifi

Amongst the correctional worker population, a wide range of demographic characteristics shape mental health outcomes, organizational stigma, and treatment-seeking, including gender and/or sex differences. Yet, considerations of the relationship between gender and especially sex and mental health in correctional systems internationally remain understudied and have not been investigated on a national scale. In the current national study, we quantitatively analyze Canadian provincial and territorial correctional workers' (n = 3,740) sex correlates with other sociodemographic variables, and examine the prevalence of potentially psychologically traumatic events (PPTEs), correctional-specific PPTEs, occupational stressors, suicide-related behaviour (ideation, plan, and attempt), and several mental health disorders. Survey findings indicate statistically significant sex differences in exposure to all types of PPTEs, with the exception of captivity and life-threatening illness or injury. Males reported higher odds of being exposed to all types of PPTEs than females, with the exception of sexual assault and other unwanted or uncomfortable sexual experiences, which females had higher odds of experiencing. Statistically significant sex differences were also evident in exposure to all types of correctional-specific PPTEs, except for instances where a person died while under their supervision. Other significant relationships found are discussed and reiterate the necessity of incorporating concerns for gender and/or sex equality and balance in correctional settings into mental health training regimen, as well as highlight several areas for future research.

在教养所工作人员群体中,广泛的人口特征影响了心理健康结果、组织污名和寻求治疗,包括性别和/或性别差异。然而,国际上对惩教系统中性别,特别是性与心理健康之间关系的考虑仍未得到充分研究,尚未在全国范围内进行调查。在当前的国家研究中,我们定量分析了加拿大省和地区惩教工作者(n = 3,740)的性别与其他社会人口变量的相关性,并检查了潜在心理创伤事件(ppte)、惩教特有的ppte、职业压力源、自杀相关行为(意念、计划和企图)和几种精神健康障碍的患病率。调查结果表明,除圈养和危及生命的疾病或伤害外,所有类型的ppte暴露在统计上存在显著的性别差异。据报道,男性比女性更有可能接触到各种类型的ppte,但性侵犯和其他不想要的或不舒服的性经历除外,女性经历这些的几率更高。除了在他们的监督下死亡的情况外,在所有类型的惩教专用ppte的暴露中,统计上显著的性别差异也很明显。讨论了发现的其他重要关系,并重申了将惩教环境中的性别和/或性别平等与平衡问题纳入心理健康培训方案的必要性,并强调了未来研究的几个领域。
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引用次数: 0
Effect of hypnosis on psychological distress in female university students with premenstrual syndrome. 催眠对女大学生经前综合征心理困扰的影响。
IF 2.7 Pub Date : 2025-12-26 DOI: 10.1007/s44192-025-00355-7
Sousan Heydarpour, Fatemeh Heydarpour, Fateme Dehghan, Yousef Torabi
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引用次数: 0
How three different theories of depression converge at inflammation. 三种不同的抑郁理论是如何汇聚在炎症上的。
IF 2.7 Pub Date : 2025-12-24 DOI: 10.1007/s44192-025-00312-4
B Baumberger, L Batey, P Hashemi

Three main theories of depression have been developed: the monoamine, plasticity and inflammation theories. While each theory has been bolstered by decades of excellent scientific evidence, individually each idea falls short for developing universally effective treatments for depression. In this perspective, we present the history and development of each theory and discuss the therapies that follow each hypothesis. We provide a unique perspective by highlighting the historical evolution, clinical implications, and the nexus between the three hypotheses. We emphasise how the theories are mutually inclusive and influence one another and are smaller parts of a larger puzzle. We suggest that future therapies should involve all three: ze: monoamines, plasticity and inflammation.

抑郁症的主要理论有三种:单胺理论、可塑性理论和炎症理论。虽然每一种理论都得到了几十年优秀科学证据的支持,但单独来看,每一种理论都无法开发出普遍有效的抑郁症治疗方法。从这个角度来看,我们介绍了每个理论的历史和发展,并讨论了遵循每个假设的治疗方法。我们提供了一个独特的视角,强调历史演变,临床意义,以及三个假设之间的联系。我们强调这些理论是如何相互包容和相互影响的,并且是一个更大难题的小部分。我们建议未来的治疗应该包括这三种:单胺、可塑性和炎症。
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引用次数: 0
Evaluation of the neuroprotective activity of Momordica dioica against aluminum chloride (AlCl3)-Induced alzheimer's disease in Wistar rats. 苦瓜对氯化铝(AlCl3)诱导的Wistar大鼠阿尔茨海默病神经保护作用的评价。
IF 2.7 Pub Date : 2025-12-24 DOI: 10.1007/s44192-025-00243-0
Vrushali Neve, Sayyed Saqlain, Addepalli Veeranjaneyulu, Pawan Karwa, Harshad Kapare, Ketaki Yeralkar
<p><p>Alzheimer's disease is a brain condition that slowly erodes a person's memory and cognitive abilities. It is caused by damage to brain cell, particularly in the hippocampus, a region crucial for memory. By 2050 worldwide no. of AD is going increases. Various therapeutic strategies have been explored for AD. The use of herbal products is one of the treatment regimens for AD. In this study, we examined how a herbal extract from Momordica dioica could potentially protect Wistar rats from AD caused by Aluminum chloride. Aluminum chloride (AlCl<sub>3</sub>) is widely used in preclinical studies to induce Alzheimer-like symptoms, as chronic exposure is known to promote oxidative stress, neuroinflammation, and cholinergic dysfunction-hallmarks of Alzheimer's disease pathology. A total of 86 Wistar rats were randomly assigned to nine experimental groups (n = 6-10 per group), including a normal control group and an Alzheimer's disease (AD) model group. One group treated with Donepezil (2.05 mg/kg), three groups treated with different doses of herbal extract of Momordica dioica (100, 200 and 400 mg/kg), and three groups treated with a combination of Donepezil and herbal extract of Momordica dioica (std + 100, std + 200 and std + 400 mg/kg). The aluminum chloride (17 mg/kg, p.o) was administered once daily for 7 days to induce AD. From the 8th day onward, the herbal extract of Momordica dioica was administered orally for 21 consecutive days at doses of 100, 200, and 400 mg/kg to groups 4, 5, and 6 respectively, as well as in combination with Donepezil (2.05 mg/kg) in groups 7, 8, and 9. This brought the total duration of the study to 28 days." Elevated Plus Maze and Forced Swim test was used for the behavioral assessment. After that, brain samples were collected for biochemical analysis. Herbal Extract significantly improved AlCl3-induced behavioral impairments and cognition deficits in Forced Swim Test, Elevated Plus Maze Test significantly with high dose. Then, herbal extract of Momordica dioica facilitated cholinergic activity via inhibiting acetylcholinesterase (AChE) activity. Besides, herbal extract of Momordica dioica decreased lipid peroxidation level & Nitrite level but enhanced levels of glutathione, Succinate dehydrogenase, Catalase and superoxide dismutase and results are more convincing with high dose. Histopathological analysis further confirmed reduced neuronal degeneration and better preservation of brain architecture, especially at higher doses of the herbal extract." The results suggested that herbal extract of Momordica dioica ameliorated AlCl3-induced cognitive and memory impairments, possibly through regulating AChE activity, suppressing oxidative stress. The herbal extract of Momordica dioica significantly improved behavioral impairments and cognition deficits, particularly at high doses. It facilitates cholinergic activity by inhibiting AChE activity and reduced oxidative stress. Overall, the conclusion states that the herbal ex
阿尔茨海默病是一种大脑疾病,它会慢慢侵蚀人的记忆和认知能力。它是由脑细胞受损引起的,尤其是对记忆至关重要的海马体。到2050年,世界排名第一。阿尔茨海默病的发病率正在上升。人们已经探索了各种治疗AD的策略。使用草药产品是阿尔茨海默病的治疗方案之一。在这项研究中,我们研究了苦瓜提取物如何潜在地保护Wistar大鼠免受氯化铝引起的AD。氯化铝(AlCl3)被广泛用于临床前研究,以诱导阿尔茨海默病样症状,因为已知慢性暴露会促进氧化应激、神经炎症和胆碱能功能障碍,这些都是阿尔茨海默病的病理特征。将86只Wistar大鼠随机分为9个实验组(每组n = 6 ~ 10只),分别为正常对照组和AD模型组。多奈哌齐组(2.05 mg/kg)、多奈哌齐加苦瓜提取物组(100、200、400 mg/kg)、多奈哌齐加苦瓜提取物组(std + 100、std + 200、std + 400 mg/kg)。采用氯化铝(17 mg/kg, p.o),每天1次,连续7 d诱导AD。从第8天起,4、5、6组分别以100、200、400 mg/kg的剂量口服苦瓜提取物,连续21 d; 7、8、9组分别与多奈哌齐(2.05 mg/kg)合用。这使得研究的总持续时间达到了28天。”行为学评价采用高架迷宫和强迫游泳试验。之后,采集大脑样本进行生化分析。高剂量草药提取物显著改善了alcl3诱导的强迫游泳、高程+迷宫实验中的行为障碍和认知障碍。苦参提取物通过抑制乙酰胆碱酯酶(AChE)活性促进胆碱能活性。此外,苦瓜提取物降低了脂质过氧化水平和亚硝酸盐水平,但提高了谷胱甘肽、琥珀酸脱氢酶、过氧化氢酶和超氧化物歧化酶水平,且高剂量效果更有说服力。组织病理学分析进一步证实,特别是在高剂量的草药提取物下,神经元变性减少,大脑结构得到更好的保存。”结果表明,苦瓜提取物可能通过调节乙酰胆碱酯酶活性、抑制氧化应激来改善alcl3诱导的认知和记忆障碍。苦瓜草药提取物显著改善行为障碍和认知缺陷,特别是在高剂量下。它通过抑制乙酰胆碱酯酶活性和减少氧化应激促进胆碱能活性。总之,结论表明草药提取物可以改善与AD相关的记忆障碍。
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引用次数: 0
Translation, validation and reliability of depression, anxiety, and stress 42 (DASS-42) among Herat University students. 赫拉特大学大学生抑郁、焦虑和压力42 (DASS-42)的翻译、验证和信度
IF 2.7 Pub Date : 2025-12-24 DOI: 10.1007/s44192-025-00335-x
Nasar Ahmad Shayan, Ali Rahimi, Abdul Momen Waseq, Osman Dag, Hilal Özcebe

Objective: This study aimed to evaluate the validity and reliability of the Dari-translated Depression, Anxiety, and Stress Scale-42 (DASS-42) in university students in Herat, Afghanistan.

Methods: A cross-sectional study was conducted from August to November 2022 with 1000 undergraduate students at Herat University. Participants completed a self-reported Dari-translated DASS-42 questionnaire. Confirmatory Factor Analysis (CFA) was employed to assess the scale's factor structure, and internal consistency was evaluated using Cronbach's alpha. The test-retest reliability was also examined over a 2-3 week interval.

Results: The CFA results indicated a good fit for the three-factor model, with RMSEA = 0.04 and CFI = 0.919, confirming the construct validity of the scale. Internal consistency was high, with Cronbach's alpha values of 0.867, 0.831, and 0.848 for depression, anxiety, and stress, respectively. The test-retest reliability coefficients for depression, anxiety, and stress were 0.956, 0.923, and 0.951, respectively. Additionally, DASS-42 showed significant correlations with other established mental health measures, indicating good convergent validity.

Conclusion: The DASS-42 is a valid and reliable instrument for assessing depression, anxiety, and stress among university students in Herat, Brazil. This comprehensive validation addresses previous limitations and supports the use of the scale in both clinical and non-clinical settings for early detection and intervention. Future research should explore the scale's applicability in more diverse Afghan populations and incorporate longitudinal designs to validate its predictive validity further.

目的:本研究旨在评估DASS-42抑郁、焦虑和压力量表(DASS-42)在阿富汗赫拉特市大学生中的效度和信度。方法:于2022年8月至11月对赫拉特大学1000名本科生进行横断面研究。参与者完成了一份自我报告的达利语翻译DASS-42问卷。采用验证性因子分析(Confirmatory Factor Analysis, CFA)评估量表的因子结构,并采用Cronbach’s alpha评估量表的内部一致性。测试-重测的信度也在2-3周的间隔内进行了检查。结果:CFA结果表明三因素模型拟合良好,RMSEA = 0.04, CFI = 0.919,证实了量表的结构效度。内部一致性高,抑郁、焦虑和压力的Cronbach’s alpha值分别为0.867、0.831和0.848。抑郁、焦虑、应激的重测信度系数分别为0.956、0.923、0.951。此外,DASS-42与其他已建立的心理健康测量具有显著相关性,表明具有良好的收敛效度。结论:DASS-42量表是巴西赫拉特市大学生抑郁、焦虑和压力评估的有效、可靠的工具。这项全面的验证解决了以前的局限性,并支持在临床和非临床环境中使用该量表进行早期检测和干预。未来的研究应该探索量表在更多样化的阿富汗人口中的适用性,并结合纵向设计来进一步验证其预测有效性。
{"title":"Translation, validation and reliability of depression, anxiety, and stress 42 (DASS-42) among Herat University students.","authors":"Nasar Ahmad Shayan, Ali Rahimi, Abdul Momen Waseq, Osman Dag, Hilal Özcebe","doi":"10.1007/s44192-025-00335-x","DOIUrl":"10.1007/s44192-025-00335-x","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the validity and reliability of the Dari-translated Depression, Anxiety, and Stress Scale-42 (DASS-42) in university students in Herat, Afghanistan.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from August to November 2022 with 1000 undergraduate students at Herat University. Participants completed a self-reported Dari-translated DASS-42 questionnaire. Confirmatory Factor Analysis (CFA) was employed to assess the scale's factor structure, and internal consistency was evaluated using Cronbach's alpha. The test-retest reliability was also examined over a 2-3 week interval.</p><p><strong>Results: </strong>The CFA results indicated a good fit for the three-factor model, with RMSEA = 0.04 and CFI = 0.919, confirming the construct validity of the scale. Internal consistency was high, with Cronbach's alpha values of 0.867, 0.831, and 0.848 for depression, anxiety, and stress, respectively. The test-retest reliability coefficients for depression, anxiety, and stress were 0.956, 0.923, and 0.951, respectively. Additionally, DASS-42 showed significant correlations with other established mental health measures, indicating good convergent validity.</p><p><strong>Conclusion: </strong>The DASS-42 is a valid and reliable instrument for assessing depression, anxiety, and stress among university students in Herat, Brazil. This comprehensive validation addresses previous limitations and supports the use of the scale in both clinical and non-clinical settings for early detection and intervention. Future research should explore the scale's applicability in more diverse Afghan populations and incorporate longitudinal designs to validate its predictive validity further.</p>","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":"5 1","pages":"199"},"PeriodicalIF":2.7,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12738504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pilot randomized controlled trial to evaluate the efficacy of transitional care interventions to improve mental health outcomes using a continuity of care approach for individuals with severe mental illness. 一项试点随机对照试验,旨在评估过渡性护理干预措施对重度精神疾病患者使用连续性护理方法改善精神健康结果的有效性。
IF 2.7 Pub Date : 2025-12-22 DOI: 10.1007/s44192-025-00329-9
Irasangappa Mudakavi, Sreevani Rentala, Naresh Nebhinani
{"title":"A pilot randomized controlled trial to evaluate the efficacy of transitional care interventions to improve mental health outcomes using a continuity of care approach for individuals with severe mental illness.","authors":"Irasangappa Mudakavi, Sreevani Rentala, Naresh Nebhinani","doi":"10.1007/s44192-025-00329-9","DOIUrl":"10.1007/s44192-025-00329-9","url":null,"abstract":"","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":"5 1","pages":"196"},"PeriodicalIF":2.7,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12722612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and correlates of onychophagia among Egyptian medical students: a cross-sectional study. 埃及医学生中onychophagia的患病率及其相关因素:一项横断面研究。
IF 2.7 Pub Date : 2025-12-21 DOI: 10.1007/s44192-025-00327-x
Asmaa Mohammad Ahmad Mohammad, Rabab Ahmed Abd El-Hai Hammad, Noha M Elghazally

Background: Onychophagia, or chronic nail biting, is a common body-focused repetitive behaviour often associated with psychological stress, anxiety, and perfectionism. Medical students may be at increased risk due to sustained mental and emotional pressures.

Objectives: To assess the prevalence of onychophagia, identify associated risk factors, and examine the relationship between perceived stress levels and the frequency or severity of nail biting among medical students at Tanta University in Egypt.

Methods: A cross-sectional study was conducted among 330 undergraduate students using a structured self-administered questionnaire comprising sociodemographic data, onychophagia-related items, and the Perceived Stress Scale (PSS).

Results: 57.3% of the students were actively practicing onychophagia, and it was reported more often among males (63.5%) than females (36.5%), but the difference was not statistically significant (p = 0.134). Among participants with onychophagia (n = 189), 18 (9.5%) were smokers, 63 (33.3%) reported a positive family history, and 30 (15.9%) reported fear of public spaces. These factors were significantly associated with nail-biting behaviour (p < 0.01 for all). No significant difference in Perceived Stress Scale scores was observed between students with and without onychophagia, and stress severity was not associated with the frequency or duration of nail-biting episodes.

Conclusion: Onychophagia was common among medical students and was significantly associated with smoking, positive family history, and fear of public spaces. Behavioural interventions are recommended among university students.

背景:咬甲癖,或慢性咬指甲,是一种常见的以身体为中心的重复性行为,通常与心理压力、焦虑和完美主义有关。由于持续的精神和情绪压力,医学生可能面临更高的风险。目的:评估埃及坦塔大学医学生咬指甲症的患病率,确定相关危险因素,并检查感知压力水平与咬指甲频率或严重程度之间的关系。方法:对330名大学生进行横断面研究,采用结构化的自填问卷,包括社会人口学数据、恐惧症相关项目和感知压力量表(PSS)。结果:57.3%的学生积极练习食手症,其中男生(63.5%)多于女生(36.5%),但差异无统计学意义(p = 0.134)。在189名恐食症患者中,18名(9.5%)是吸烟者,63名(33.3%)报告有阳性家族史,30名(15.9%)报告害怕公共场所。这些因素与咬指甲行为显著相关(p结论:咬指甲癖在医学生中很常见,与吸烟、阳性家族史和公共场所恐惧显著相关。行为干预被推荐给大学生。
{"title":"Prevalence and correlates of onychophagia among Egyptian medical students: a cross-sectional study.","authors":"Asmaa Mohammad Ahmad Mohammad, Rabab Ahmed Abd El-Hai Hammad, Noha M Elghazally","doi":"10.1007/s44192-025-00327-x","DOIUrl":"10.1007/s44192-025-00327-x","url":null,"abstract":"<p><strong>Background: </strong>Onychophagia, or chronic nail biting, is a common body-focused repetitive behaviour often associated with psychological stress, anxiety, and perfectionism. Medical students may be at increased risk due to sustained mental and emotional pressures.</p><p><strong>Objectives: </strong>To assess the prevalence of onychophagia, identify associated risk factors, and examine the relationship between perceived stress levels and the frequency or severity of nail biting among medical students at Tanta University in Egypt.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 330 undergraduate students using a structured self-administered questionnaire comprising sociodemographic data, onychophagia-related items, and the Perceived Stress Scale (PSS).</p><p><strong>Results: </strong>57.3% of the students were actively practicing onychophagia, and it was reported more often among males (63.5%) than females (36.5%), but the difference was not statistically significant (p = 0.134). Among participants with onychophagia (n = 189), 18 (9.5%) were smokers, 63 (33.3%) reported a positive family history, and 30 (15.9%) reported fear of public spaces. These factors were significantly associated with nail-biting behaviour (p < 0.01 for all). No significant difference in Perceived Stress Scale scores was observed between students with and without onychophagia, and stress severity was not associated with the frequency or duration of nail-biting episodes.</p><p><strong>Conclusion: </strong>Onychophagia was common among medical students and was significantly associated with smoking, positive family history, and fear of public spaces. Behavioural interventions are recommended among university students.</p>","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":"195"},"PeriodicalIF":2.7,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12719362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of body dysmorphic disorder, gender differences and association with body mass index among medical students in Pakistan. 巴基斯坦医学生身体畸形障碍的患病率、性别差异及其与体重指数的关系
IF 2.7 Pub Date : 2025-12-20 DOI: 10.1007/s44192-025-00343-x
Mohammad Abdullah Hameed, Taneer Abbas, Muhammad Muneeb Warriach, Natasha Nadeem, Ambreen Tauseef, Mohsin Ali Syed
{"title":"Prevalence of body dysmorphic disorder, gender differences and association with body mass index among medical students in Pakistan.","authors":"Mohammad Abdullah Hameed, Taneer Abbas, Muhammad Muneeb Warriach, Natasha Nadeem, Ambreen Tauseef, Mohsin Ali Syed","doi":"10.1007/s44192-025-00343-x","DOIUrl":"10.1007/s44192-025-00343-x","url":null,"abstract":"","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":"13"},"PeriodicalIF":2.7,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phthalate exposure and its impact on mental health risk in the elderly Thai population. 邻苯二甲酸盐暴露及其对泰国老年人心理健康风险的影响
IF 2.7 Pub Date : 2025-12-19 DOI: 10.1007/s44192-025-00314-2
Orawan Kaewboonchoo, Maruth Bhrasartsuwan, Kraichat Tantrakarnapa, Chatchai Ekpanyaskul

Phthalates, ubiquitous environmental contaminants, are widely used in daily life. Although their adverse health effects across developmental stages have been well-documented, their impact on elderly populations remains unexplored. This study investigated the association between phthalate exposure and mental health issues (depression, anxiety, and stress). A community-based cross-sectional study was conducted among 688 individuals aged ≥ 60 years in Thailand. Phthalate exposure was assessed using five urinary phthalate metabolites: mono(2-ethylhexyl) phthalate (MEHP), monoisobutyl phthalate, mono-n-butyl phthalate (MnBP), monoethyl phthalate, and monomethyl phthalate. Mental health status was evaluated using the Depression Anxiety Stress Scales (DASS-21), a self-administered questionnaire that assesses depression, anxiety, and stress, along with demographic data. Binary logistic regression adjusted for potential confounders was used to analyze associations with mental health risks. The detection rates for the phthalate metabolites ranged between 31.83 and 96.08%, with MEHP being most frequently detected. Depression emerged as the most prevalent mental health condition. Among healthy participants, those in the highest tertile of urinary MEHP and MnBP levels exhibited significantly increased odds of anxiety, with adjusted odds ratios 3.13 (95% CI 1.37-7.12) and 2.28 (95% CI 1.03-5.06), respectively. Both metabolites exhibited a dose-response relationship (p-for-trend = 0.002 and 0.034, respectively). The number needed to harm was 5.66 for MEHP and 8.09 for MnBP. Associations were not observed in individuals with underlying chronic diseases. Furthermore, no association with depression or stress was observed. In conclusion, exposure to both high- and low-molecular-weight phthalates was associated with an increased risk of anxiety among healthy older adults. However, causal inferences were not confirmed owing to the study design. Longitudinal research is warranted to clarify the underlying mechanisms and inform mental health surveillance for older individuals.

邻苯二甲酸盐是一种普遍存在的环境污染物,在日常生活中被广泛使用。尽管它们在整个发育阶段对健康的不利影响已得到充分记录,但它们对老年人的影响仍未得到探索。本研究调查了邻苯二甲酸酯暴露与心理健康问题(抑郁、焦虑和压力)之间的关系。一项以社区为基础的横断面研究对泰国688名年龄≥60岁的个体进行了研究。使用五种尿邻苯二甲酸酯代谢物:邻苯二甲酸单(2-乙基己基)酯(MEHP)、邻苯二甲酸单异丁酯、邻苯二甲酸单正丁酯(MnBP)、邻苯二甲酸单乙酯和邻苯二甲酸单甲基酯来评估邻苯二甲酸暴露。使用抑郁焦虑压力量表(DASS-21)评估心理健康状况,这是一份自我管理的问卷,评估抑郁、焦虑和压力,以及人口统计数据。采用校正潜在混杂因素的二元逻辑回归分析与心理健康风险的关联。邻苯二甲酸酯代谢物检出率为31.83 ~ 96.08%,以MEHP检出率最高。抑郁症成为最普遍的心理健康状况。在健康参与者中,尿MEHP和MnBP水平最高的参与者表现出显著增加的焦虑几率,调整后的优势比分别为3.13 (95% CI 1.37-7.12)和2.28 (95% CI 1.03-5.06)。两种代谢物均表现出剂量-反应关系(p-for-trend分别= 0.002和0.034)。MEHP和MnBP需要伤害的数量分别为5.66和8.09。在有潜在慢性疾病的个体中未观察到相关。此外,没有观察到与抑郁或压力有关。总之,暴露于高分子量和低分子量邻苯二甲酸盐与健康老年人焦虑风险增加有关。然而,由于研究设计的原因,因果关系尚未得到证实。有必要进行纵向研究,以阐明潜在的机制,并为老年人的心理健康监测提供信息。
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引用次数: 0
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