In this research, we introduce an advanced methodology for the calculation of bulk light sources tailored for free-form surface design, focusing on the principle of energy conservation. This method is especially relevant for the evolving needs of micro-LED packaging, highlighting its potential in this burgeoning field. Our work includes the development of an algorithm for creating freeform-designed chip-scale package (FDCSP) components. These components seamlessly integrate LEDs and lenses, underscoring our commitment to advancing free-form surface design in chip-level packaging. By adhering to the principle of energy conservation, our approach facilitates a meticulous comparison of simulation outcomes with predefined target functions. This enables the iterative correction of discrepancies, employing layering techniques to refine the design until the simulated results closely align with our goals, as demonstrated by an appropriate difference curve. The practical application of these simulations leads to the innovative design of FDCSP devices. Notably, these devices are not just suitable for traditional applications in backlight modules but are explicitly optimized for the emerging sector of micro-LED packaging. Our successful demonstration of these FDCSP devices within backlight modules represents a significant achievement. It underscores the effectiveness of our design strategy and its expansive potential to transform micro-LED packaging solutions. This research not only contributes to the theoretical understanding of energy conservation in lighting design but also paves the way for groundbreaking applications in micro-LED and backlight module technologies.
在这项研究中,我们介绍了一种先进的方法,用于计算为自由曲面设计量身定制的体光源,重点关注能量守恒原则。这种方法与微型 LED 封装不断发展的需求特别相关,凸显了它在这一新兴领域的潜力。我们的工作包括开发一种用于创建自由形态设计芯片级封装(FDCSP)组件的算法。这些组件无缝集成了 LED 和透镜,彰显了我们在芯片级封装中推进自由形态表面设计的承诺。通过坚持能量守恒原则,我们的方法有助于将模拟结果与预定义的目标函数进行细致比较。这样就能反复修正差异,采用分层技术来完善设计,直到模拟结果与我们的目标密切吻合,正如适当的差异曲线所显示的那样。这些模拟的实际应用促成了 FDCSP 器件的创新设计。值得注意的是,这些器件不仅适用于背光模块的传统应用,还针对微型 LED 封装这一新兴领域进行了明确优化。我们在背光模块中成功演示了这些 FDCSP 器件,这是一项重大成就。它凸显了我们设计策略的有效性及其改变微型 LED 封装解决方案的巨大潜力。这项研究不仅有助于从理论上理解照明设计中的节能问题,还为微型 LED 和背光模块技术的突破性应用铺平了道路。
{"title":"Advancing LED technology: the FDCSP element's breakthrough in mini and micro-LED packaging and backlight module enhancement.","authors":"Jo-Hsiang Chen, Che-Hsuan Huang, Tzu-Yi Lee, Fang-Chung Chen, Tsung-Sheng Kao, Hao-Chung Kuo","doi":"10.1186/s11671-024-04033-5","DOIUrl":"10.1186/s11671-024-04033-5","url":null,"abstract":"<p><p>In this research, we introduce an advanced methodology for the calculation of bulk light sources tailored for free-form surface design, focusing on the principle of energy conservation. This method is especially relevant for the evolving needs of micro-LED packaging, highlighting its potential in this burgeoning field. Our work includes the development of an algorithm for creating freeform-designed chip-scale package (FDCSP) components. These components seamlessly integrate LEDs and lenses, underscoring our commitment to advancing free-form surface design in chip-level packaging. By adhering to the principle of energy conservation, our approach facilitates a meticulous comparison of simulation outcomes with predefined target functions. This enables the iterative correction of discrepancies, employing layering techniques to refine the design until the simulated results closely align with our goals, as demonstrated by an appropriate difference curve. The practical application of these simulations leads to the innovative design of FDCSP devices. Notably, these devices are not just suitable for traditional applications in backlight modules but are explicitly optimized for the emerging sector of micro-LED packaging. Our successful demonstration of these FDCSP devices within backlight modules represents a significant achievement. It underscores the effectiveness of our design strategy and its expansive potential to transform micro-LED packaging solutions. This research not only contributes to the theoretical understanding of energy conservation in lighting design but also paves the way for groundbreaking applications in micro-LED and backlight module technologies.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"94"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-27DOI: 10.1186/s11671-024-04038-0
Ana Carolina Costa Santos, Gabriela Carvalho Batista, Rafaela Cavalcante Cerqueira, Mariana Gonçalves Lisboa, Joberth Lee Correa, Tamiris Sabrina Rodrigues, Murillo Néia Thomaz da Silva, Vinícius Prado Bittar, Serena Mares Malta, Natalia Carine Lima Dos Santos, Foued Salmen Espindola, Ana Maria Bonetti, Carlos Ueira-Vieira
This study explores the green synthesis of silver nanoparticles (AgNPs) using a methanolic extract of fermented pollen from Tetragonisca angustula, a species of stingless bees. The AgNPs exhibit spherical morphology, low charge values, and suspension stability, with their unique composition attributed to elements from the pollen extract. Antioxidant assays show comparable activity between the pollen extract and AgNPs, emphasizing the retention of antioxidant effects. The synthesized AgNPs demonstrate antimicrobial activity against multidrug-resistant bacteria, highlighting their potential in combating bacterial resistance. The AgNPs exhibit no toxic effects on Drosophila melanogaster and even enhance the hatching rate of eggs. The study underscores the innovative use of stingless bee pollen extract in green synthesis, offering insights into the varied applications of AgNPs in biomedicine.
{"title":"Green synthesis of silver nanoparticle using pollen extract from Tetragonisca angustula a stingless bee.","authors":"Ana Carolina Costa Santos, Gabriela Carvalho Batista, Rafaela Cavalcante Cerqueira, Mariana Gonçalves Lisboa, Joberth Lee Correa, Tamiris Sabrina Rodrigues, Murillo Néia Thomaz da Silva, Vinícius Prado Bittar, Serena Mares Malta, Natalia Carine Lima Dos Santos, Foued Salmen Espindola, Ana Maria Bonetti, Carlos Ueira-Vieira","doi":"10.1186/s11671-024-04038-0","DOIUrl":"10.1186/s11671-024-04038-0","url":null,"abstract":"<p><p>This study explores the green synthesis of silver nanoparticles (AgNPs) using a methanolic extract of fermented pollen from Tetragonisca angustula, a species of stingless bees. The AgNPs exhibit spherical morphology, low charge values, and suspension stability, with their unique composition attributed to elements from the pollen extract. Antioxidant assays show comparable activity between the pollen extract and AgNPs, emphasizing the retention of antioxidant effects. The synthesized AgNPs demonstrate antimicrobial activity against multidrug-resistant bacteria, highlighting their potential in combating bacterial resistance. The AgNPs exhibit no toxic effects on Drosophila melanogaster and even enhance the hatching rate of eggs. The study underscores the innovative use of stingless bee pollen extract in green synthesis, offering insights into the varied applications of AgNPs in biomedicine.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"92"},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-27DOI: 10.1186/s11671-024-04034-4
Hafiz Muhammad Akhtar, Muhammad Latif, Mahtab Ahmad Khan, M Abdullah, Taj Muhammad Khan
In this paper, smart integration of cold dielectric barrier discharge (DBD) plasma in various geometrical arrangements with laser ablation at atmospheric pressure for nanomaterial was described. A composite Co:ZnO target was ablated in an airflow by a nanosecond (ns) laser (wavelength: 1064 nm, pulse duration: 30 ns) using fluence of 5 J-cm-2 at a repetition rate of 10 Hz. The nanomaterial produced under vertical and oblique plasma streams, surface discharge and gas flow, were compared. Utilization surface discharge markedly improved the material adhesion by altering surface intrinsic behavior, inducing anticipated surface energy activation, chemical changes, and the formation of a densely packed solid structure. Under all conditions, the material consistently retained its crystalline nature, elemental composition, and ultraviolet emission characteristics. These preliminary findings hold promise for additional research, suggesting avenues for making complex materials in a flexible environment. Such new advancements could facilitate applications in the biomedical, catalysis, pharmaceutical, and surgical device domains.
{"title":"Smart integration of cold plasma stream and surface discharge with ns laser ablation for composite nanomaterial.","authors":"Hafiz Muhammad Akhtar, Muhammad Latif, Mahtab Ahmad Khan, M Abdullah, Taj Muhammad Khan","doi":"10.1186/s11671-024-04034-4","DOIUrl":"10.1186/s11671-024-04034-4","url":null,"abstract":"<p><p>In this paper, smart integration of cold dielectric barrier discharge (DBD) plasma in various geometrical arrangements with laser ablation at atmospheric pressure for nanomaterial was described. A composite Co:ZnO target was ablated in an airflow by a nanosecond (ns) laser (wavelength: 1064 nm, pulse duration: 30 ns) using fluence of 5 J-cm<sup>-2</sup> at a repetition rate of 10 Hz. The nanomaterial produced under vertical and oblique plasma streams, surface discharge and gas flow, were compared. Utilization surface discharge markedly improved the material adhesion by altering surface intrinsic behavior, inducing anticipated surface energy activation, chemical changes, and the formation of a densely packed solid structure. Under all conditions, the material consistently retained its crystalline nature, elemental composition, and ultraviolet emission characteristics. These preliminary findings hold promise for additional research, suggesting avenues for making complex materials in a flexible environment. Such new advancements could facilitate applications in the biomedical, catalysis, pharmaceutical, and surgical device domains.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"93"},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-21DOI: 10.1186/s11671-024-04020-w
Haochen Zhu, Anthony Szymczyk, Aziz Ghoufi
Nanofiltration (NF) and reverse osmosis (RO) processes are physical separation technologies used to remove contaminants from liquid streams by employing dense polymer-based membranes with nanometric voids that confine fluids at the nanoscale. At this level, physical properties such as solvent and solute permeabilities are intricately linked to molecular interactions. Initially, numerous studies focused on developing macroscopic transport models to gain insights into separation properties at the nanometer scale. However, continuum-based models have limitations in nanoconfined situations that can be overcome by force field molecular simulations. Continuum-based models heavily rely on bulk properties, often neglecting critical factors like liquid structuring, pore geometry, and molecular/chemical specifics. Molecular/mesoscale simulations, while encompassing these details, often face limitations in time and spatial scales. Therefore, achieving a comprehensive understanding of transport requires a synergistic integration of both approaches through a multiscale approach that effectively combines and merges both scales. This review aims to provide a comprehensive overview of the state-of-the-art in multiscale modeling of transport through NF/RO membranes, spanning from the nanoscale to continuum media.
{"title":"Multiscale modelling of transport in polymer-based reverse-osmosis/nanofiltration membranes: present and future.","authors":"Haochen Zhu, Anthony Szymczyk, Aziz Ghoufi","doi":"10.1186/s11671-024-04020-w","DOIUrl":"10.1186/s11671-024-04020-w","url":null,"abstract":"<p><p>Nanofiltration (NF) and reverse osmosis (RO) processes are physical separation technologies used to remove contaminants from liquid streams by employing dense polymer-based membranes with nanometric voids that confine fluids at the nanoscale. At this level, physical properties such as solvent and solute permeabilities are intricately linked to molecular interactions. Initially, numerous studies focused on developing macroscopic transport models to gain insights into separation properties at the nanometer scale. However, continuum-based models have limitations in nanoconfined situations that can be overcome by force field molecular simulations. Continuum-based models heavily rely on bulk properties, often neglecting critical factors like liquid structuring, pore geometry, and molecular/chemical specifics. Molecular/mesoscale simulations, while encompassing these details, often face limitations in time and spatial scales. Therefore, achieving a comprehensive understanding of transport requires a synergistic integration of both approaches through a multiscale approach that effectively combines and merges both scales. This review aims to provide a comprehensive overview of the state-of-the-art in multiscale modeling of transport through NF/RO membranes, spanning from the nanoscale to continuum media.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"91"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-20DOI: 10.1186/s11671-024-04030-8
Fan Yang, Xuyang Wang, Xianlai Song, Weilin Yang
Nano-switch structures are important control elements in nanoelectromechanical systems and have potential applications in future nanodevices. This paper analyzes the effects of surface effects, geometric nonlinearity, electrostatic forces, and intermolecular forces on the nonlinear bending behavior and adhesion stability of nano-switches. Based on the Von Karman geometric nonlinearity theory, four types of boundary conditions for the nano-switch structure were specifically calculated. The results show that surface effects have a significant impact on the nonlinear bending and adhesion stability of nano-switches. Surface effects increase the adhesion voltage of the nano-switch and decrease its adhesion displacement, and as the size of the nano-switch structure increases, the impact of surface effects decreases. A comparative analysis of the linear theory and the nonlinear theory results shows that the adhesion voltage predicted by the linear theory is smaller than that predicted by the nonlinear theory. The effect of geometric nonlinearity increases as the size of the nano-switch structure increases, as the distance between the electrodes increases, and as the aspect ratio of the nano-switch structure increases. These findings provide theoretical support and reference for the design and use of future nanodevices and nanoelectromechanical systems.
纳米开关结构是纳米机电系统中的重要控制元件,在未来的纳米设备中具有潜在的应用价值。本文分析了表面效应、几何非线性、静电力和分子间力对纳米开关非线性弯曲行为和粘附稳定性的影响。基于 Von Karman 几何非线性理论,具体计算了纳米开关结构的四种边界条件。结果表明,表面效应对纳米开关的非线性弯曲和粘附稳定性有显著影响。随着纳米开关结构尺寸的增大,表面效应的影响减小。对线性理论和非线性理论结果的对比分析表明,线性理论预测的粘附电压小于非线性理论预测的粘附电压。几何非线性的影响随着纳米开关结构尺寸的增大、电极间距的增大以及纳米开关结构纵横比的增大而增大。这些发现为未来纳米器件和纳米机电系统的设计和使用提供了理论支持和参考。
{"title":"Analysis of nonlinear bending behavior of nano-switches considering surface effects.","authors":"Fan Yang, Xuyang Wang, Xianlai Song, Weilin Yang","doi":"10.1186/s11671-024-04030-8","DOIUrl":"10.1186/s11671-024-04030-8","url":null,"abstract":"<p><p>Nano-switch structures are important control elements in nanoelectromechanical systems and have potential applications in future nanodevices. This paper analyzes the effects of surface effects, geometric nonlinearity, electrostatic forces, and intermolecular forces on the nonlinear bending behavior and adhesion stability of nano-switches. Based on the Von Karman geometric nonlinearity theory, four types of boundary conditions for the nano-switch structure were specifically calculated. The results show that surface effects have a significant impact on the nonlinear bending and adhesion stability of nano-switches. Surface effects increase the adhesion voltage of the nano-switch and decrease its adhesion displacement, and as the size of the nano-switch structure increases, the impact of surface effects decreases. A comparative analysis of the linear theory and the nonlinear theory results shows that the adhesion voltage predicted by the linear theory is smaller than that predicted by the nonlinear theory. The effect of geometric nonlinearity increases as the size of the nano-switch structure increases, as the distance between the electrodes increases, and as the aspect ratio of the nano-switch structure increases. These findings provide theoretical support and reference for the design and use of future nanodevices and nanoelectromechanical systems.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"90"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.1186/s11671-024-03990-1
Yuanpeng Xiong, Bo Wu, Yuanzhi Lin, Mingwen Zhang, Jintian Chen
In this study, a simple route for the synthesis of hierarchical W18O49 assembled by nanowires is reported. The morphologies and formation of W18O49 single-crystal could be controlled by changing the concentration of WCl6-ethanol solution. This synthesis strategy has the advantages that the hierarchical W18O49 microspheres could be economic synthesized at 180 °C without adding additives. Furthermore, efficient optical absorption properties in ultraviolet, visible and near-infrared region were obtained for the hierarchical W18O49 microspheres comparing with nanowires. These results will further promote the research of tungsten-based oxide nanomaterials.
{"title":"Facile synthesis of hierarchical W<sub>18</sub>O<sub>49</sub> microspheres by solvothermal method and their optical absorption properties.","authors":"Yuanpeng Xiong, Bo Wu, Yuanzhi Lin, Mingwen Zhang, Jintian Chen","doi":"10.1186/s11671-024-03990-1","DOIUrl":"10.1186/s11671-024-03990-1","url":null,"abstract":"<p><p>In this study, a simple route for the synthesis of hierarchical W<sub>18</sub>O<sub>49</sub> assembled by nanowires is reported. The morphologies and formation of W<sub>18</sub>O<sub>49</sub> single-crystal could be controlled by changing the concentration of WCl<sub>6</sub>-ethanol solution. This synthesis strategy has the advantages that the hierarchical W<sub>18</sub>O<sub>49</sub> microspheres could be economic synthesized at 180 °C without adding additives. Furthermore, efficient optical absorption properties in ultraviolet, visible and near-infrared region were obtained for the hierarchical W<sub>18</sub>O<sub>49</sub> microspheres comparing with nanowires. These results will further promote the research of tungsten-based oxide nanomaterials.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"89"},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-16DOI: 10.1186/s11671-024-03971-4
Wei Li, Xing Liu, Yifan Wang, Lu Peng, Xin Jin, Zhaohui Jiang, Zengge Guo, Jie Chen, Wenyu Wang
With the popularity of smart terminals, wearable electronic devices have shown great market prospects, especially high-sensitivity pressure sensors, which can monitor micro-stimuli and high-precision dynamic external stimuli, and will have an important impact on future functional development. Compressible flexible sensors have attracted wide attention due to their simple sensing mechanism and the advantages of light weight and convenience. Sensors with high sensitivity are very sensitive to pressure and can detect resistance/current changes under pressure, which has been widely studied. On this basis, this review focuses on analyzing the performance impact of device structure design strategies on high sensitivity pressure sensors. The design of structures can be divided into interface microstructures and three-dimensional framework structures. The preparation methods of various structures are introduced in detail, and the current research status and future development challenges are summarized.
{"title":"Research on high sensitivity piezoresistive sensor based on structural design.","authors":"Wei Li, Xing Liu, Yifan Wang, Lu Peng, Xin Jin, Zhaohui Jiang, Zengge Guo, Jie Chen, Wenyu Wang","doi":"10.1186/s11671-024-03971-4","DOIUrl":"10.1186/s11671-024-03971-4","url":null,"abstract":"<p><p>With the popularity of smart terminals, wearable electronic devices have shown great market prospects, especially high-sensitivity pressure sensors, which can monitor micro-stimuli and high-precision dynamic external stimuli, and will have an important impact on future functional development. Compressible flexible sensors have attracted wide attention due to their simple sensing mechanism and the advantages of light weight and convenience. Sensors with high sensitivity are very sensitive to pressure and can detect resistance/current changes under pressure, which has been widely studied. On this basis, this review focuses on analyzing the performance impact of device structure design strategies on high sensitivity pressure sensors. The design of structures can be divided into interface microstructures and three-dimensional framework structures. The preparation methods of various structures are introduced in detail, and the current research status and future development challenges are summarized.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"88"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-09DOI: 10.1186/s11671-024-04007-7
J Nandhini, E Karthikeyan, S Rajeshkumar
Biomedical nanocomposites, which are an upcoming breed of mischievous materials, have ushered in a new dimension in the healthcare sector. Incorporating these materials tends to boost features this component already possesses and give might to things these components could not withstand alone. The biopolymer, which carries the nanoparticles, can simultaneously improve the composite's stiffness and biological characteristics, and vice versa. This increases the options of the composite and the number of times it can be used. The bio-nanocomposites and nanoparticles enable the ecocompatibility of the medicine in their biodegradability, and they, in this way, have ecological sustainability. The outcome is the improved properties of medicine and its associated positive impact on the environment. They have broad applications in antimicrobial agents, drug carriers, tissue regeneration, wound care, dentistry, bioimaging, and bone filler, among others. The dissertation on the elements of bio-nanocomposites emphasizes production techniques, their diverse applications in medicine, match-up issues, and future-boasting prospects in the bio-nanocomposites field. Through the utilization of such materials, scientists can develop more suitable for the environment and healthy biomedical solutions, and world healthcare in this way improves as well.
{"title":"Eco-friendly bio-nanocomposites: pioneering sustainable biomedical advancements in engineering.","authors":"J Nandhini, E Karthikeyan, S Rajeshkumar","doi":"10.1186/s11671-024-04007-7","DOIUrl":"10.1186/s11671-024-04007-7","url":null,"abstract":"<p><p>Biomedical nanocomposites, which are an upcoming breed of mischievous materials, have ushered in a new dimension in the healthcare sector. Incorporating these materials tends to boost features this component already possesses and give might to things these components could not withstand alone. The biopolymer, which carries the nanoparticles, can simultaneously improve the composite's stiffness and biological characteristics, and vice versa. This increases the options of the composite and the number of times it can be used. The bio-nanocomposites and nanoparticles enable the ecocompatibility of the medicine in their biodegradability, and they, in this way, have ecological sustainability. The outcome is the improved properties of medicine and its associated positive impact on the environment. They have broad applications in antimicrobial agents, drug carriers, tissue regeneration, wound care, dentistry, bioimaging, and bone filler, among others. The dissertation on the elements of bio-nanocomposites emphasizes production techniques, their diverse applications in medicine, match-up issues, and future-boasting prospects in the bio-nanocomposites field. Through the utilization of such materials, scientists can develop more suitable for the environment and healthy biomedical solutions, and world healthcare in this way improves as well.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"86"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11082105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-09DOI: 10.1186/s11671-024-04029-1
Chiara Schirripa Spagnolo, Stefano Luin
Temporal resolution is a key parameter in the observation of dynamic processes, as in the case of single molecules motions visualized in real time in two-dimensions by wide field (fluorescence) microscopy, but a systematic investigation of its effects in all the single particle tracking analysis steps is still lacking. Here we present tools to quantify its impact on the estimation of diffusivity and of its distribution using one of the most popular tracking software for biological applications on simulated data and movies. We found important shifts and different widths for diffusivity distributions, depending on the interplay of temporal sampling conditions with various parameters, such as simulated diffusivity, density of spots, signal-to-noise ratio, lengths of trajectories, and kind of boundaries in the simulation. We examined conditions starting from the ones of experiments on the fluorescently labelled receptor p75NTR, a relatively fast-diffusing membrane receptor (diffusivity around 0.5-1 µm2/s), visualized by TIRF microscopy on the basal membrane of living cells. From the analysis of the simulations, we identified the best conditions in cases similar to these ones; considering also the experiments, we could confirm a range of values of temporal resolution suitable for obtaining reliable diffusivity results. The procedure we present can be exploited in different single particle/molecule tracking applications to find an optimal temporal resolution.
{"title":"Impact of temporal resolution in single particle tracking analysis.","authors":"Chiara Schirripa Spagnolo, Stefano Luin","doi":"10.1186/s11671-024-04029-1","DOIUrl":"10.1186/s11671-024-04029-1","url":null,"abstract":"<p><p>Temporal resolution is a key parameter in the observation of dynamic processes, as in the case of single molecules motions visualized in real time in two-dimensions by wide field (fluorescence) microscopy, but a systematic investigation of its effects in all the single particle tracking analysis steps is still lacking. Here we present tools to quantify its impact on the estimation of diffusivity and of its distribution using one of the most popular tracking software for biological applications on simulated data and movies. We found important shifts and different widths for diffusivity distributions, depending on the interplay of temporal sampling conditions with various parameters, such as simulated diffusivity, density of spots, signal-to-noise ratio, lengths of trajectories, and kind of boundaries in the simulation. We examined conditions starting from the ones of experiments on the fluorescently labelled receptor p75<sup>NTR</sup>, a relatively fast-diffusing membrane receptor (diffusivity around 0.5-1 µm<sup>2</sup>/s), visualized by TIRF microscopy on the basal membrane of living cells. From the analysis of the simulations, we identified the best conditions in cases similar to these ones; considering also the experiments, we could confirm a range of values of temporal resolution suitable for obtaining reliable diffusivity results. The procedure we present can be exploited in different single particle/molecule tracking applications to find an optimal temporal resolution.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"87"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11082114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-09DOI: 10.1186/s11671-024-04031-7
Donghyuk Kim, Hyunjung Kim
Among the various anti-cancer treatments, photothermal therapy (PTT) is gaining traction as it is a non-invasive treatment. PTT is a treatment technique involving the use of a laser to raise the temperature of the target tumor until it dies. In this study, the effects of PTT under various conditions of squamous cell carcinoma (SCC) occurring in the skin were numerically analyzed and optimized. Gold nanoparticles (AuNPs) with different radii were injected into the center of the SCC. Subsequently, the diffusion behavior of the AuNPs was analyzed to calculate the distribution area of the AuNPs that changed over time. Furthermore, at each elapsed time point after injection, the temperature distribution in the tissue was calculated, as treatment was performed using varying laser intensities. The diffusion coefficient of AuNPs was calculated using the Stokes-Einstein equation, and diffusion behavior of AuNPs in biological tissues was analyzed using the convection-diffusion equation. Additionally, temperature distribution was analyzed using the Pennes bioheat equation. The effect of PTT under each condition was quantitatively analyzed using apoptotic variables. As a result, As the radius of AuNPs increased, the optimal treatment start time was derived as 2 h, 8 h, 8 h, and 12 h, respectively, and the laser intensity at that time was derived as 0.44 W, 0.46 W, 0.42 W, and 0.42 W, respectively. The study findings will provide reference for the optimization of the efficacy of PTT.
在各种抗癌疗法中,光热疗法(PTT)由于是一种非侵入性疗法而日益受到重视。光热疗法是一种利用激光提高目标肿瘤温度直至其死亡的治疗技术。本研究对发生在皮肤上的鳞状细胞癌(SCC)在不同条件下的 PTT 效果进行了数值分析和优化。将不同半径的金纳米粒子(AuNPs)注入鳞状细胞癌中心。随后,分析了 AuNPs 的扩散行为,以计算随时间变化的 AuNPs 分布面积。此外,在注射后的每个时间点,由于使用了不同强度的激光进行治疗,因此还计算了组织中的温度分布。利用斯托克斯-爱因斯坦方程计算了 AuNPs 的扩散系数,并利用对流扩散方程分析了 AuNPs 在生物组织中的扩散行为。此外,还利用 Pennes 生物热方程分析了温度分布。利用细胞凋亡变量定量分析了 PTT 在各种条件下的影响。结果表明,随着 AuNPs 半径的增加,最佳治疗开始时间分别为 2 h、8 h、8 h 和 12 h,此时的激光强度分别为 0.44 W、0.46 W、0.42 W 和 0.42 W。研究结果将为优化 PTT 的疗效提供参考。
{"title":"Effect of radius-dependent diffusion behavior of various gold nanoparticles on photothermal therapy.","authors":"Donghyuk Kim, Hyunjung Kim","doi":"10.1186/s11671-024-04031-7","DOIUrl":"10.1186/s11671-024-04031-7","url":null,"abstract":"<p><p>Among the various anti-cancer treatments, photothermal therapy (PTT) is gaining traction as it is a non-invasive treatment. PTT is a treatment technique involving the use of a laser to raise the temperature of the target tumor until it dies. In this study, the effects of PTT under various conditions of squamous cell carcinoma (SCC) occurring in the skin were numerically analyzed and optimized. Gold nanoparticles (AuNPs) with different radii were injected into the center of the SCC. Subsequently, the diffusion behavior of the AuNPs was analyzed to calculate the distribution area of the AuNPs that changed over time. Furthermore, at each elapsed time point after injection, the temperature distribution in the tissue was calculated, as treatment was performed using varying laser intensities. The diffusion coefficient of AuNPs was calculated using the Stokes-Einstein equation, and diffusion behavior of AuNPs in biological tissues was analyzed using the convection-diffusion equation. Additionally, temperature distribution was analyzed using the Pennes bioheat equation. The effect of PTT under each condition was quantitatively analyzed using apoptotic variables. As a result, As the radius of AuNPs increased, the optimal treatment start time was derived as 2 h, 8 h, 8 h, and 12 h, respectively, and the laser intensity at that time was derived as 0.44 W, 0.46 W, 0.42 W, and 0.42 W, respectively. The study findings will provide reference for the optimization of the efficacy of PTT.</p>","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"84"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11082121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}