Pub Date : 2025-12-01DOI: 10.1016/j.eimce.2025.05.001
Mercedes García-Gasalla , Sophia Pinecki Socias , Pablo A. Fraile , Victoria Fernández-Baca , Aroa Villoslada , Antonio Adrover , Sandra Gregorio , Marta González-Moreno , Alfredo Pinheiro Martins , Alexander Zidouh , Gemma Mut , Meritxell Gavaldà , Melchor Riera , Luisa Martín Pena , Javier Murillas Angoiti
Introduction
Q fever (QF) is a zoonotic infection caused by Coxiella burnetii. Previous studies suggest that the incidence in the island of Majorca may be high. The objective was to know the epidemiological, clinical, diagnostic, and therapeutic characteristics of acute QF (AQF) on the island of Majorca during the years 2017–2022.
Methods
Retrospective analysis of a series of cases of AQF diagnosed in 3 out 4 hospitals of the Health Service of the island of Majorca. AQF was considered if a clinically compatible syndrome was present with one of the following serological criteria: confirmed AQF if IgG seroconversion phase II, very possible if only IgG ≥1/128 is available in addition to a positive IgM, and AQF possible if IgG≥ 1/512 with negative IgM or if IgM positive with negative IgG in a single serological determination.
Results
223 cases of AQF were diagnosed, of which 102 (45.7%) were confirmed, 84 (37.7%) very probable and 37 (16.6%) probable AQF. Prolonged febrile syndrome was the most frequent clinical diagnosis (107, 48.0%), followed by pneumonia with/without pleural effusion (49, 21.9%), acute hepatitis (38, 17.0%), pericarditis and/or myocarditis (6, 2.6%). Three patients developed endocarditis (one in the acute phase, two others during follow-up). The median number of cases per year was 34 (p25–p75: 31.7–40.25). AQF-related mortality was 1.8% (4 patients).
Conclusion
AQF is a preventable and little recognized zoonosis, causing significant morbidity and mortality in Majorca.
{"title":"Acute Q fever in Majorca island 2017–2022. An underestimated problem","authors":"Mercedes García-Gasalla , Sophia Pinecki Socias , Pablo A. Fraile , Victoria Fernández-Baca , Aroa Villoslada , Antonio Adrover , Sandra Gregorio , Marta González-Moreno , Alfredo Pinheiro Martins , Alexander Zidouh , Gemma Mut , Meritxell Gavaldà , Melchor Riera , Luisa Martín Pena , Javier Murillas Angoiti","doi":"10.1016/j.eimce.2025.05.001","DOIUrl":"10.1016/j.eimce.2025.05.001","url":null,"abstract":"<div><h3>Introduction</h3><div><span>Q fever (QF) is a zoonotic infection caused by </span><span><em>Coxiella burnetii</em></span>. Previous studies suggest that the incidence in the island of Majorca may be high. The objective was to know the epidemiological, clinical, diagnostic, and therapeutic characteristics of acute QF (AQF) on the island of Majorca during the years 2017–2022.</div></div><div><h3>Methods</h3><div>Retrospective analysis of a series of cases of AQF diagnosed in 3 out 4 hospitals of the Health Service of the island of Majorca. AQF was considered if a clinically compatible syndrome was present with one of the following serological criteria: confirmed AQF if IgG seroconversion phase II, very possible if only IgG ≥1/128 is available in addition to a positive IgM, and AQF possible if IgG≥ 1/512 with negative IgM or if IgM positive with negative IgG in a single serological determination.</div></div><div><h3>Results</h3><div><span>223 cases of AQF were diagnosed, of which 102 (45.7%) were confirmed, 84 (37.7%) very probable and 37 (16.6%) probable AQF. Prolonged febrile syndrome was the most frequent clinical diagnosis (107, 48.0%), followed by pneumonia with/without pleural effusion<span> (49, 21.9%), acute hepatitis (38, 17.0%), pericarditis and/or </span></span>myocarditis<span> (6, 2.6%). Three patients developed endocarditis (one in the acute phase, two others during follow-up). The median number of cases per year was 34 (p25–p75: 31.7–40.25). AQF-related mortality was 1.8% (4 patients).</span></div></div><div><h3>Conclusion</h3><div>AQF is a preventable and little recognized zoonosis, causing significant morbidity and mortality in Majorca.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 10","pages":"Pages 639-644"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.eimce.2025.09.011
Cristina Jiménez-Arroyo , Natalia Molinero , Rosa del Campo , Susana Delgado , M. Victoria Moreno-Arribas
Metagenomics has decisively advanced the study of the gut microbiome, enabling a better understanding of its importance for human health. Metataxonomics, based on the sequencing of the 16S rRNA gene, provides taxonomic profiles of prokaryotes, while shotgun metagenomics allows a comprehensive characterization of all DNA present in a sample. With adequate sequencing depth, the latter increases taxonomic resolution to the strain level and provides detailed information on the functional potential of the microbiota. However, the lack of standardization in sample collection and processing, sequencing technologies, and data management limits the comparability of results and their implementation in clinical laboratories. This review offers a practical and updated framework on metagenomic methodologies, data analysis, and the application of artificial intelligence tools, highlighting advances and best practices to facilitate the integration of functional microbiome analysis into clinical practice and to overcome current challenges.
{"title":"Human gut microbiome study through metagenomics: Recent advances and challenges for clinical implementation","authors":"Cristina Jiménez-Arroyo , Natalia Molinero , Rosa del Campo , Susana Delgado , M. Victoria Moreno-Arribas","doi":"10.1016/j.eimce.2025.09.011","DOIUrl":"10.1016/j.eimce.2025.09.011","url":null,"abstract":"<div><div>Metagenomics has decisively advanced the study of the gut microbiome, enabling a better understanding of its importance for human health. Metataxonomics, based on the sequencing of the 16S rRNA gene, provides taxonomic profiles of prokaryotes, while shotgun metagenomics allows a comprehensive characterization of all DNA present in a sample. With adequate sequencing depth, the latter increases taxonomic resolution to the strain level and provides detailed information on the functional potential of the microbiota. However, the lack of standardization in sample collection and processing, sequencing technologies, and data management limits the comparability of results and their implementation in clinical laboratories. This review offers a practical and updated framework on metagenomic methodologies, data analysis, and the application of artificial intelligence tools, highlighting advances and best practices to facilitate the integration of functional microbiome analysis into clinical practice and to overcome current challenges.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 10","pages":"Pages 698-708"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.eimce.2025.06.002
Francisco Javier Membrillo de Novales , Alfonso J. Rodriguez-Morales , Adriana Sucari , Nancy Virginia Sandoval Paiz , Ivan Arturo Rodríguez Sabogal , Wendy Moncada Navas , Susana Lloveras , Gustavo Lopardo , Virgilio Lezcano , Alexis M. Holguin , Inés Cerón , Rosa Abreu , Míriam J. Álvarez-Martínez , on behalf of the Latin American Alliance of Infectious Diseases and Clinical Microbiology (ALEIMC)
{"title":"One year of the Latin American Alliance in Infectious Diseases and Clinical Microbiology: achievements and future challenges","authors":"Francisco Javier Membrillo de Novales , Alfonso J. Rodriguez-Morales , Adriana Sucari , Nancy Virginia Sandoval Paiz , Ivan Arturo Rodríguez Sabogal , Wendy Moncada Navas , Susana Lloveras , Gustavo Lopardo , Virgilio Lezcano , Alexis M. Holguin , Inés Cerón , Rosa Abreu , Míriam J. Álvarez-Martínez , on behalf of the Latin American Alliance of Infectious Diseases and Clinical Microbiology (ALEIMC)","doi":"10.1016/j.eimce.2025.06.002","DOIUrl":"10.1016/j.eimce.2025.06.002","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 9","pages":"Pages 550-551"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.eimce.2025.09.008
José María Serrano Romero , Antonio Sampedro Padilla , José Pablo Mazuelas Teatino , Javier Rodríguez-Granger , Juan Antonio Reguera , Fernando Cobo , José María Navarro Marí
Introduction
Rubella is a generally mild viral infection, but it carries the risk of potentially severe complications, especially during pregnancy. Immunity to rubella is determined using commercial chemiluminescent immunoassays, calibrated with international standards. Despite this, discrepancies have been observed in the results obtained by different methods.
Methods
This study evaluates the performance of two chemiluminescent immunoassays (CLIAs) (Alinity i® Rubella IgG and Atellica IM® Rubella IgG) in determining rubella immunity in patient sera with low levels of anti-rubella virus (RV) IgG, using immunoblot (IB) as the reference method.
Results
101 sera were analyzed, with 72 (71.3%) classified by IB as positive and 28 (27.7%) as negative. Both assays showed 100% specificity, with sensitivity ranging from 15% for Alinity i® to 66% for Atellica IM®. The concordance between IB and CLIA Atellica was 75% when equivocal results were considered negative and 95% when considered positive, whereas for CLIA Alinity, it was 39% and 66%, respectively.
Conclusions
The evaluated CLIA showed discrepancies in determining rubella immunity, highlight inadequate standardisation in the quantification of specific IgG, which could lead to errors in patient management, incorrect classification of immune status, and unnecessary revaccinations in this patient population.
{"title":"Performance of two chemiluminescent assays in determining rubella IgG in sera with low levels of specific IgG","authors":"José María Serrano Romero , Antonio Sampedro Padilla , José Pablo Mazuelas Teatino , Javier Rodríguez-Granger , Juan Antonio Reguera , Fernando Cobo , José María Navarro Marí","doi":"10.1016/j.eimce.2025.09.008","DOIUrl":"10.1016/j.eimce.2025.09.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Rubella is a generally mild viral infection, but it carries the risk of potentially severe complications, especially during pregnancy. Immunity to rubella is determined using commercial chemiluminescent immunoassays, calibrated with international standards. Despite this, discrepancies have been observed in the results obtained by different methods.</div></div><div><h3>Methods</h3><div>This study evaluates the performance of two chemiluminescent immunoassays (CLIAs) (Alinity i® Rubella IgG and Atellica IM® Rubella IgG) in determining rubella immunity in patient sera with low levels of anti-rubella virus (RV) IgG, using immunoblot (IB) as the reference method.</div></div><div><h3>Results</h3><div>101 sera were analyzed, with 72 (71.3%) classified by IB as positive and 28 (27.7%) as negative. Both assays showed 100% specificity, with sensitivity ranging from 15% for Alinity i® to 66% for Atellica IM®. The concordance between IB and CLIA Atellica was 75% when equivocal results were considered negative and 95% when considered positive, whereas for CLIA Alinity, it was 39% and 66%, respectively.</div></div><div><h3>Conclusions</h3><div>The evaluated CLIA showed discrepancies in determining rubella immunity, highlight inadequate standardisation in the quantification of specific IgG, which could lead to errors in patient management, incorrect classification of immune status, and unnecessary revaccinations in this patient population.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 9","pages":"Pages 596-599"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.eimce.2025.01.011
Marta Arsuaga Vicente , Guillermo Ruiz-Carrascoso , Fernando De la Calle-Prieto , Javier Sotillo Gallego , Rosa De Miguel-Buckley , Mar Lago Nuñez , Daniel Mesado Martinez , Marta Díaz Menéndez
Introduction
Schistosomiasis is a neglected tropical disease endemic in 78 countries worldwide. The acute phase, commonly referred to as Katayama fever, is more frequently observed in travelers than in migrants. Despite significant progress in understanding its pathology, many aspects of this disease remain unclear, posing challenges to timely diagnosis and management.
Methods
This observational retrospective study was conducted at the National Referral Unit for Imported Tropical Diseases, located at Hospital La Paz-Carlos III in Madrid, Spain. The study included a total of 14 members of a dance and percussion ensemble that traveled to the Republic of Guinea from March 3 to March 18, 2023. Patients with confirmed or probable schistosomiasis were included in the analysis.
Results
Twelve patients had suspected acute schistosomiasis. Of these, 78.5% were female. The predominant clinical manifestations included fever (91.6%), eosinophilia (100%), acute diarrhea (91.6%), and abdominal pain (83.3%). All patients reported a history of freshwater exposure in Guinea. Schistosoma serology was positive in all cases, and stool samples from five patients revealed the presence of Schistosoma mansoni eggs. Acute symptoms were managed with corticosteroids, leading to clinical improvement in all cases. Thereafter, all patients were treated with praziquantel at a dose of 40 mg/kg/day, administered in two separate doses four weeks apart.
Conclusion
Freshwater exposure in tropical regions is the primary risk factor for acquiring schistosomiasis. Early diagnosis and treatment during the acute phase are crucial to prevent complications and long-term sequelae.
{"title":"Outbreak of Schistosomiasis mansoni in a Spanish dance and percussion ensemble acquired in the Republic of Guinea","authors":"Marta Arsuaga Vicente , Guillermo Ruiz-Carrascoso , Fernando De la Calle-Prieto , Javier Sotillo Gallego , Rosa De Miguel-Buckley , Mar Lago Nuñez , Daniel Mesado Martinez , Marta Díaz Menéndez","doi":"10.1016/j.eimce.2025.01.011","DOIUrl":"10.1016/j.eimce.2025.01.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Schistosomiasis is a neglected tropical disease endemic in 78 countries worldwide. The acute phase, commonly referred to as Katayama fever, is more frequently observed in travelers than in migrants. Despite significant progress in understanding its pathology, many aspects of this disease remain unclear, posing challenges to timely diagnosis and management.</div></div><div><h3>Methods</h3><div>This observational retrospective study was conducted at the National Referral Unit for Imported Tropical Diseases, located at Hospital La Paz-Carlos III in Madrid, Spain. The study included a total of 14 members of a dance and percussion ensemble that traveled to the Republic of Guinea from March 3 to March 18, 2023. Patients with confirmed or probable schistosomiasis were included in the analysis.</div></div><div><h3>Results</h3><div>Twelve patients had suspected acute schistosomiasis. Of these, 78.5% were female. The predominant clinical manifestations included fever (91.6%), eosinophilia (100%), acute diarrhea (91.6%), and abdominal pain (83.3%). All patients reported a history of freshwater exposure in Guinea. Schistosoma serology was positive in all cases, and stool samples from five patients revealed the presence of <em>Schistosoma mansoni</em><span> eggs. Acute symptoms were managed with corticosteroids, leading to clinical improvement in all cases. Thereafter, all patients were treated with praziquantel at a dose of 40</span> <!-->mg/kg/day, administered in two separate doses four weeks apart.</div></div><div><h3>Conclusion</h3><div>Freshwater exposure in tropical regions is the primary risk factor for acquiring schistosomiasis. Early diagnosis and treatment during the acute phase are crucial to prevent complications and long-term sequelae.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 9","pages":"Pages 571-576"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.eimce.2025.02.016
Marta Santos , Jesica Martín Carmona , Anais Corma-Gómez , Margarita Pérez-García , Carmen Martín-Sierra , Pilar Rincón-Mayo , Juan Antonio Pineda , Luis Miguel Real , Juan Macías
Introduction
The WHO proposed to achieve hepatitis B virus (HBV) elimination by 2030, but this goal is very difficult to attain. People living with HIV (PLWH) may represent a subset where microelimination can be reached sooner. This study aimed to assess the incidence of HBV infections and changes in the prevalence of active HBV infection among PLWH in Spain.
Methods
A prospective cohort study, including all PLWH attending a university hospital in Southern Spain from January 2011 to December 2022, was conducted. Serum HBV markers (HBsAg, anti-HBs, anti-HBc) were tested at baseline and at least yearly afterwards. Incident cases were identified by anti-HBc seroconversion.
Results
Nine hundred and eighty PLWH were included. At the beginning of the study, 26 (2.7% [95% CI: 1.7–3.8%]) tested positive for HBsAg, 428 (43.7% [95% CI: 42.8–49.4%]) for anti-HBc and 386 (39.4% [95% CI: 39.8–46.3%]) for anti-HBs. After a median (Q1–Q3) follow-up of 115 (35–143) months, two new infections were documented, yielding an incidence rate of 2.24 (95% CI: 0.27–8.1)/100,000 person-years. The prevalence of active HBV infection declined from 3.4% [95% CI: 2.0–5.0%] in 2011 to 2% [95% CI: 1.0–3.0%] in 2022 (p for linear trend = 0.027). At the end of the study, 167 (24%) PLWH still were susceptible to HBV.
Conclusions
The incidence of HBV infection among PLWH in Spain is close to the WHO target. The prevalence of active HBV infection has decreased substantially during the last 12 years. These data suggest that micro-elimination of HBV/HIV infection is on the track in Spain.
{"title":"Progression towards microelimination of hepatitis B virus infection among people living with HIV in Spain","authors":"Marta Santos , Jesica Martín Carmona , Anais Corma-Gómez , Margarita Pérez-García , Carmen Martín-Sierra , Pilar Rincón-Mayo , Juan Antonio Pineda , Luis Miguel Real , Juan Macías","doi":"10.1016/j.eimce.2025.02.016","DOIUrl":"10.1016/j.eimce.2025.02.016","url":null,"abstract":"<div><h3>Introduction</h3><div>The WHO proposed to achieve hepatitis B virus (HBV) elimination by 2030, but this goal is very difficult to attain. People living with HIV (PLWH) may represent a subset where microelimination can be reached sooner. This study aimed to assess the incidence of HBV infections and changes in the prevalence of active HBV infection among PLWH in Spain.</div></div><div><h3>Methods</h3><div>A prospective cohort study, including all PLWH attending a university hospital in Southern Spain from January 2011 to December 2022, was conducted. Serum HBV markers (HBsAg, anti-HBs, anti-HBc) were tested at baseline and at least yearly afterwards. Incident cases were identified by anti-HBc seroconversion.</div></div><div><h3>Results</h3><div>Nine hundred and eighty PLWH were included. At the beginning of the study, 26 (2.7% [95% CI: 1.7–3.8%]) tested positive for HBsAg, 428 (43.7% [95% CI: 42.8–49.4%]) for anti-HBc and 386 (39.4% [95% CI: 39.8–46.3%]) for anti-HBs. After a median (Q1–Q3) follow-up of 115 (35–143) months, two new infections were documented, yielding an incidence rate of 2.24 (95% CI: 0.27–8.1)/100,000 person-years. The prevalence of active HBV infection declined from 3.4% [95% CI: 2.0–5.0%] in 2011 to 2% [95% CI: 1.0–3.0%] in 2022 (<em>p</em> for linear trend<!--> <!-->=<!--> <!-->0.027). At the end of the study, 167 (24%) PLWH still were susceptible to HBV.</div></div><div><h3>Conclusions</h3><div>The incidence of HBV infection among PLWH in Spain is close to the WHO target. The prevalence of active HBV infection has decreased substantially during the last 12 years. These data suggest that micro-elimination of HBV/HIV infection is on the track in Spain.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 9","pages":"Pages 577-584"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.eimce.2025.05.010
Itziar Diego-Yagüe , Antonio Ramos-Martinez , Jorge Calderón-Parra
{"title":"More on endocarditis risk scores in gram positive bacteremias: Caveats to their implantation in clinical practice","authors":"Itziar Diego-Yagüe , Antonio Ramos-Martinez , Jorge Calderón-Parra","doi":"10.1016/j.eimce.2025.05.010","DOIUrl":"10.1016/j.eimce.2025.05.010","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 9","pages":"Pages 547-549"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.eimce.2025.06.007
Begoña Fachal Bugarín, Lucía Ramos Merino, Joaquín Manuel Serrano Arreba, Alicia Alonso Álvarez, Ramón María Fernández Varela, Berta Pernas Souto, Laura Gutiérrez Fernández, María Dolores Sousa Regueiro, Enrique Míguez Rey, Efrén Sánchez Vidal
Introduction
Most infections caused by Listeria monocytogenes occur in individuals with predisposing conditions, such as advanced age or the use of immunosuppressive therapies, and primarily manifest as bacteremia or meningoencephalitis. Osteoarticular infections are uncommon and typically affect joint prostheses, with late-onset infections following surgery. Treatment in these cases should include antibiotic therapy along with a surgical strategy, which generally involves the removal of the affected prosthesis.
Methods
Two cases of prosthetic joint infection caused by L. monocytogenes are presented, along with a narrative review of the English and Spanish literature via PubMed up to December 2024.
Results
To the best of our knowledge, 52 cases of prosthetic joint infection caused by L. monocytogenes have been reported since 2000. All patients had predisposing conditions, with advanced age being the most common (mean age of 71 years). Most cases were late infections following surgery. Combined treatment (antibiotic therapy and surgery) was used in two-thirds of cases. The prognosis was favorable in almost all instances.
Discussion
It is important to consider L. monocytogenes in the etiological diagnosis of prosthetic joint infections, especially in elderly or immunocompromised patients. While the most used antibiotics have been ampicillin and cotrimoxazole, oxazolidinones could serve as an oral alternative for the treatment of these infections.
{"title":"Listeria monocytogenes prosthetic joint infection: Two clinical cases and a review of the literature","authors":"Begoña Fachal Bugarín, Lucía Ramos Merino, Joaquín Manuel Serrano Arreba, Alicia Alonso Álvarez, Ramón María Fernández Varela, Berta Pernas Souto, Laura Gutiérrez Fernández, María Dolores Sousa Regueiro, Enrique Míguez Rey, Efrén Sánchez Vidal","doi":"10.1016/j.eimce.2025.06.007","DOIUrl":"10.1016/j.eimce.2025.06.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Most infections caused by <span><span>Listeria monocytogenes</span></span><span><span> occur in individuals with predisposing conditions, such as advanced age or the use of immunosuppressive therapies, and primarily manifest as </span>bacteremia<span> or meningoencephalitis. Osteoarticular infections are uncommon and typically affect joint prostheses, with late-onset infections following surgery. Treatment in these cases should include antibiotic therapy along with a surgical strategy, which generally involves the removal of the affected prosthesis.</span></span></div></div><div><h3>Methods</h3><div>Two cases of prosthetic joint infection caused by <em>L. monocytogenes</em> are presented, along with a narrative review of the English and Spanish literature via PubMed up to December 2024.</div></div><div><h3>Results</h3><div>To the best of our knowledge, 52 cases of prosthetic joint infection caused by <em>L. monocytogenes</em> have been reported since 2000. All patients had predisposing conditions, with advanced age being the most common (mean age of 71 years). Most cases were late infections following surgery. Combined treatment (antibiotic therapy and surgery) was used in two-thirds of cases. The prognosis was favorable in almost all instances.</div></div><div><h3>Discussion</h3><div>It is important to consider <em>L. monocytogenes</em><span><span><span> in the etiological diagnosis of prosthetic joint infections, especially in elderly or immunocompromised patients. While the most used antibiotics have been </span>ampicillin<span> and cotrimoxazole, </span></span>oxazolidinones could serve as an oral alternative for the treatment of these infections.</span></div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 9","pages":"Pages 591-595"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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