Pub Date : 2026-03-01Epub Date: 2026-03-07DOI: 10.1016/j.eimce.2026.503113
Ana Isabel Vargas Herrera , Miriam Torrecillas , Michele Hernández Cabrera , Ernesto Santana Suárez , Valentina González Pérez , Isabel de Miguel Martínez
{"title":"From chest to brain: Multiple intracranial mass lesions in an immunocompetent young man","authors":"Ana Isabel Vargas Herrera , Miriam Torrecillas , Michele Hernández Cabrera , Ernesto Santana Suárez , Valentina González Pérez , Isabel de Miguel Martínez","doi":"10.1016/j.eimce.2026.503113","DOIUrl":"10.1016/j.eimce.2026.503113","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 3","pages":"Article 503113"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-02-20DOI: 10.1016/j.eimce.2026.503066
Marta Díaz-Menéndez , Rosa De Miguel-Buckley , Fernando De la Calle-Prieto , Marta Arsuaga
{"title":"When the traveler ages: health implications of cultural programs for the elderly","authors":"Marta Díaz-Menéndez , Rosa De Miguel-Buckley , Fernando De la Calle-Prieto , Marta Arsuaga","doi":"10.1016/j.eimce.2026.503066","DOIUrl":"10.1016/j.eimce.2026.503066","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 3","pages":"Article 503066"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neisseria meningitidis as a cause of cellulitis, an uncommon presentation","authors":"Sofía Veiga Pereira, Rebeca Longueira Suárez, Antonio Moreno Flores, Martín Rubianes González","doi":"10.1016/j.eimce.2026.503062","DOIUrl":"10.1016/j.eimce.2026.503062","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 3","pages":"Article 503062"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neisseria zoodegmatis, an uncommon pathogen after a dog bite","authors":"Roberto Rilo-Antelo , Jesús Alonso-Claro , Alejandro Seoane-Estévez , Germán Bou","doi":"10.1016/j.eimce.2026.503104","DOIUrl":"10.1016/j.eimce.2026.503104","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 3","pages":"Article 503104"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-02-17DOI: 10.1016/j.eimce.2026.503052
Daniel Robles de la Osa , Cristina Sánchez del Hoyo , Claudia Pérez Urra , Lidia Hervés González , Pablo Espinel Pinedo , Carmen Beatriz Bulnes Labrador , Laura López Allúe , Elena González de Castro , Ángela Martina Montero Moretón , Fernando Santos Santamarta , Laura Pérez Citores , Javier Santos Fernández , Sergio Maestro Antolín , Bruno Antonio Moreira da Silva , Javier Barcenilla Laguna , Marta Cimavilla Román , Francisco José Rancel Medina , María Antonella Rizzo Rodríguez , Mónica Bru Arca , Jeisson Andrey Toro Santibáñez , Antonio Germán Pérez Millán
Introduction
Liver abscesses are the most common type of visceral abscess. Risk factors include diabetes mellitus, hepatobiliary diseases, liver transplantation, and proton pump inhibitor use. Diagnosis relies on imaging techniques and microbiological cultures. The aim of the study was to evaluate the clinical-epidemiological and microbiological characteristics of liver abscesses and their impact on patient prognosis.
Methods
Retrospective observational study conducted on 132 patients diagnosed with liver abscesses from 2011 to 2022 in a single hospital in Spain. Clinical, laboratory, and microbiological variables were compared, assessing mortality predictors using logistic regression and survival by treatment strategy using Cox regression.
Results
Female sex and biliary disease increase the risk of multiple liver abscesses. Liver abscess cultures are more effective for diagnosis than blood cultures. Polymicrobial blood cultures are more common in patients with a history of colorectal cancer. Early percutaneous drainage reduced hospitalization time, and broad-spectrum antibiotic therapy decreased the need for surgery. The in-hospital mortality rate was 15.1%, and was independently associated with diabetes mellitus, abscess size, and polymicrobial infection; surgery was linked to a higher mortality risk compared with drainage.
Conclusions
Liver abscess cultures are crucial for guiding antibiotic therapy, particularly given the high prevalence of polymicrobial infections. Mortality is linked to specific comorbidities and microbial findings. Early drainage and broad-spectrum antibiotics improve clinical outcomes.
{"title":"Liver abscesses: Clinical-epidemiological, microbiological characteristics and mortality predictors","authors":"Daniel Robles de la Osa , Cristina Sánchez del Hoyo , Claudia Pérez Urra , Lidia Hervés González , Pablo Espinel Pinedo , Carmen Beatriz Bulnes Labrador , Laura López Allúe , Elena González de Castro , Ángela Martina Montero Moretón , Fernando Santos Santamarta , Laura Pérez Citores , Javier Santos Fernández , Sergio Maestro Antolín , Bruno Antonio Moreira da Silva , Javier Barcenilla Laguna , Marta Cimavilla Román , Francisco José Rancel Medina , María Antonella Rizzo Rodríguez , Mónica Bru Arca , Jeisson Andrey Toro Santibáñez , Antonio Germán Pérez Millán","doi":"10.1016/j.eimce.2026.503052","DOIUrl":"10.1016/j.eimce.2026.503052","url":null,"abstract":"<div><h3>Introduction</h3><div>Liver abscesses are the most common type of visceral abscess. Risk factors include diabetes mellitus, hepatobiliary diseases, liver transplantation, and proton pump inhibitor use. Diagnosis relies on imaging techniques and microbiological cultures. The aim of the study was to evaluate the clinical-epidemiological and microbiological characteristics of liver abscesses and their impact on patient prognosis.</div></div><div><h3>Methods</h3><div>Retrospective observational study conducted on 132 patients diagnosed with liver abscesses from 2011 to 2022 in a single hospital in Spain. Clinical, laboratory, and microbiological variables were compared, assessing mortality predictors using logistic regression and survival by treatment strategy using Cox regression.</div></div><div><h3>Results</h3><div>Female sex and biliary disease increase the risk of multiple liver abscesses. Liver abscess cultures are more effective for diagnosis than blood cultures. Polymicrobial blood cultures are more common in patients with a history of colorectal cancer. Early percutaneous drainage reduced hospitalization time, and broad-spectrum antibiotic therapy decreased the need for surgery. The in-hospital mortality rate was 15.1%, and was independently associated with diabetes mellitus, abscess size, and polymicrobial infection; surgery was linked to a higher mortality risk compared with drainage.</div></div><div><h3>Conclusions</h3><div>Liver abscess cultures are crucial for guiding antibiotic therapy, particularly given the high prevalence of polymicrobial infections. Mortality is linked to specific comorbidities and microbial findings. Early drainage and broad-spectrum antibiotics improve clinical outcomes.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 3","pages":"Article 503052"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-03-07DOI: 10.1016/j.eimce.2026.503099
Lucía Platero , María del Mar Arcos , Gemma Carrión , Luz Martín-Carbonero
{"title":"Acute hepatitis A in a person living with HIV previously vaccinated with immune response","authors":"Lucía Platero , María del Mar Arcos , Gemma Carrión , Luz Martín-Carbonero","doi":"10.1016/j.eimce.2026.503099","DOIUrl":"10.1016/j.eimce.2026.503099","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 3","pages":"Article 503099"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-02-20DOI: 10.1016/j.eimce.2026.503060
Maialen Larrea Ayo , Iker Alonso González , Regino Rodríguez Álvarez , Maider Zuriarrain Alonso , Clara Lejarraga Cañas , Begoña Vilar Achabal
Introduction
Resistance to β-lactams has risen globally among Bacteroides species. Consequently, delafloxacin has emerged as a therapeutic alternative against these microorganisms. The main objective of this study is to analyse the MIC of delafloxacin in Bacteroides spp. isolates and compare it with commonly used anaerobic antimicrobial agents.
Method
The susceptibility of delafloxacin and other anaerobic antibiotics was assessed in 370 isolates of the genus Bacteroides and MIC50 and MIC90 values were determined for all antibiotics.
Results
In Bacteroides spp. and the Bacteroides fragilis sensu stricto group the MIC50 values for delafloxacin were lower than those of other antibiotics, except for tigecycline and metronidazole.
Conclusion
Given the potent in vitro anaerobic activity and its broad spectrum, delafloxacin may represent a favourable alternative in the treatment of mixed bacterial infections, particularly those involving multidrug-resistant strains.
{"title":"Delafloxacin's in vitro activity against bacteroides and its potential place in therapy","authors":"Maialen Larrea Ayo , Iker Alonso González , Regino Rodríguez Álvarez , Maider Zuriarrain Alonso , Clara Lejarraga Cañas , Begoña Vilar Achabal","doi":"10.1016/j.eimce.2026.503060","DOIUrl":"10.1016/j.eimce.2026.503060","url":null,"abstract":"<div><h3>Introduction</h3><div>Resistance to β-lactams has risen globally among Bacteroides species. Consequently, delafloxacin has emerged as a therapeutic alternative against these microorganisms. The main objective of this study is to analyse the MIC of delafloxacin in <em>Bacteroides</em> spp. isolates and compare it with commonly used anaerobic antimicrobial agents.</div></div><div><h3>Method</h3><div>The susceptibility of delafloxacin and other anaerobic antibiotics was assessed in 370 isolates of the genus <em>Bacteroides</em> and MIC<sub>50</sub> and MIC<sub>90</sub> values were determined for all antibiotics.</div></div><div><h3>Results</h3><div>In <em>Bacteroides</em> spp. and the <em>Bacteroides fragilis</em> sensu stricto group the MIC<sub>50</sub> values for delafloxacin were lower than those of other antibiotics, except for tigecycline and metronidazole.</div></div><div><h3>Conclusion</h3><div>Given the potent <em>in vitro</em> anaerobic activity and its broad spectrum, delafloxacin may represent a favourable alternative in the treatment of mixed bacterial infections, particularly those involving multidrug-resistant strains.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 3","pages":"Article 503060"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-03-07DOI: 10.1016/j.eimce.2026.503109
Nury Alejandra de León , Neri Alejandro Álvarez-Villalobos , Gloria M. González , Rogelio de J. Treviño-Rangel , Alexandra M. Montoya
Fusarium spp. has increased in relevance due to its resistance, high mortality, increasing incidence, and low preventability. The scarce treatment options compelled the development of antifungals with novel mechanisms of action. We conducted a systematic review to report on novel compounds and their activity on Fusarium spp. We searched for terms related to novel antifungals against Fusarium across multiple databases, up to February 2024. From 622 articles, only 15 articles met the eligibility criteria. The antifungals reported were manogepix (10), olorofim (3), ibrexafungerp (1), and MGCD290 (1), evaluated against 480 Fusarium isolates. Manogepix MIC/MECs had broad ranges for most Fusarium species, with notable exceptions like F. solani (MEC: ≤0.12 μg/mL) and F. fujikuroi (MEC: ≤0.25 μg/mL). Olorofim could be a good candidate for fusariosis treatment based on in vitro activity. Ibrexafungerp and MGCD290 did not show good activity as monotherapy. Further work on applications and development of new treatments against the resistant Fusarium species is essential.
{"title":"Novel antifungal compounds against Fusarium spp: A systematic review","authors":"Nury Alejandra de León , Neri Alejandro Álvarez-Villalobos , Gloria M. González , Rogelio de J. Treviño-Rangel , Alexandra M. Montoya","doi":"10.1016/j.eimce.2026.503109","DOIUrl":"10.1016/j.eimce.2026.503109","url":null,"abstract":"<div><div><em>Fusarium</em> spp. has increased in relevance due to its resistance, high mortality, increasing incidence, and low preventability. The scarce treatment options compelled the development of antifungals with novel mechanisms of action. We conducted a systematic review to report on novel compounds and their activity on <em>Fusarium</em> spp. We searched for terms related to novel antifungals against <em>Fusarium</em> across multiple databases, up to February 2024. From 622 articles, only 15 articles met the eligibility criteria. The antifungals reported were manogepix (10), olorofim (3), ibrexafungerp (1), and MGCD290 (1), evaluated against 480 <em>Fusarium</em> isolates. Manogepix MIC/MECs had broad ranges for most <em>Fusarium</em> species, with notable exceptions like <em>F. solani</em> (MEC: ≤0.12<!--> <!-->μg/mL) and <em>F. fujikuroi</em> (MEC: ≤0.25<!--> <!-->μg/mL). Olorofim could be a good candidate for fusariosis treatment based on <em>in vitro</em> activity. Ibrexafungerp and MGCD290 did not show good activity as monotherapy. Further work on applications and development of new treatments against the resistant <em>Fusarium</em> species is essential.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 3","pages":"Article 503109"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-03-07DOI: 10.1016/j.eimce.2026.503045
Diego Viasus , Jordi Carratalà
{"title":"When the masks came off: The resurgence of invasive pneumococcal disease and the road ahead","authors":"Diego Viasus , Jordi Carratalà","doi":"10.1016/j.eimce.2026.503045","DOIUrl":"10.1016/j.eimce.2026.503045","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 3","pages":"Article 503045"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-16DOI: 10.1016/j.eimce.2026.503063
Amaia Cuñado, Iratxe Ocerin, Josune Mendiola, Maitane Arrastia, Luis Piñeiro
Introduction: The incidence of Chlamydia trachomatis (CT) infection has increased in recent years, especially in young women, and can have significant consequences for their sexual and reproductive health.
Methods: Between February/2017-June/2017, screening for CT infection was offered to women aged 18-35 years who attended the Midwife/Gynecology clinic at Mendaro Hospital (Gipuzkoa), and it was extended between September/2017-February/2021 in those aged 18-25. After providing consent, a clinical-epidemiological survey was completed and a genital sample was obtained. CT was detected using a commercial PCR technique.
Results: A total of 558 women were studied: 412 aged 18-25 years and 146 aged 26-35 years. The prevalence of infection was 7.3% (95%CI 5.4-9.9%), 9.0% in those aged ≤25 years and 2.7% in those older than 25 (p = 0.013). The prevalence was higher in symptomatic women, with more sexual partners, and inconsistent condom use.
Conclusion: The high prevalence of CT infection in women aged ≤25 years indicates the need to implement screening strategies to prevent the consequences of infection and its transmission.
{"title":"Opportunistic screening and early diagnosis of Chlamydia trachomatis infection in sexually active women in a rural area of the Basque Country.","authors":"Amaia Cuñado, Iratxe Ocerin, Josune Mendiola, Maitane Arrastia, Luis Piñeiro","doi":"10.1016/j.eimce.2026.503063","DOIUrl":"https://doi.org/10.1016/j.eimce.2026.503063","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of Chlamydia trachomatis (CT) infection has increased in recent years, especially in young women, and can have significant consequences for their sexual and reproductive health.</p><p><strong>Methods: </strong>Between February/2017-June/2017, screening for CT infection was offered to women aged 18-35 years who attended the Midwife/Gynecology clinic at Mendaro Hospital (Gipuzkoa), and it was extended between September/2017-February/2021 in those aged 18-25. After providing consent, a clinical-epidemiological survey was completed and a genital sample was obtained. CT was detected using a commercial PCR technique.</p><p><strong>Results: </strong>A total of 558 women were studied: 412 aged 18-25 years and 146 aged 26-35 years. The prevalence of infection was 7.3% (95%CI 5.4-9.9%), 9.0% in those aged ≤25 years and 2.7% in those older than 25 (p = 0.013). The prevalence was higher in symptomatic women, with more sexual partners, and inconsistent condom use.</p><p><strong>Conclusion: </strong>The high prevalence of CT infection in women aged ≤25 years indicates the need to implement screening strategies to prevent the consequences of infection and its transmission.</p>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":" ","pages":"503063"},"PeriodicalIF":0.0,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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