Pub Date : 2025-08-21DOI: 10.1016/j.aimed.2025.100567
Taotao Wei , Gaozhong Dai , Tianye Liu , Yaozhou Tian
Metabolic Associated Fatty Liver Disease (MAFLD) has become a main cause of chronic liver disease globally, necessitating the development of preventive and early therapeutic strategies. Traditional Chinese Medicine (TCM) plays a significant role in human metabolism, and Jiawei Xiaoyao San (JWXYS) has demonstrated notable ameliorative effects on liver stagnation and spleen deficiency-type liver disease. However, its potential mechanisms are still unclear. This study aimed to explore the therapeutic mechanism of JWXYS in treating chronic liver disease by establishing a rat model induced by a high-fat diet. The results revealed that JWXYS could reduce serum levels of total cholesterol (TC) triglycerides (TG) and aspartate aminotransferase (AST) in model rats, significantly improve the structure of liver lobule, reduce lipid deposition in hepatocytes, and reduce the abundance of harmful intestinal flora (such as Staphylococcus and Enterococcus). In addition, JWXYS improved gut microbiota imbalance, regulated bile acid and lipid metabolism, and maintained the overall health of rats. These findings provide a theoretical basis for using JWXYS to treat chronic fatty liver disease.
{"title":"Investigating the mechanism of Jiawei Xiaoyao San in treating metabolic associated fatty liver disease (MAFLD) based on the ileal microbiota-bile acid-FXR axis","authors":"Taotao Wei , Gaozhong Dai , Tianye Liu , Yaozhou Tian","doi":"10.1016/j.aimed.2025.100567","DOIUrl":"10.1016/j.aimed.2025.100567","url":null,"abstract":"<div><div>Metabolic Associated Fatty Liver Disease (MAFLD) has become a main cause of chronic liver disease globally, necessitating the development of preventive and early therapeutic strategies. Traditional Chinese Medicine (TCM) plays a significant role in human metabolism, and Jiawei Xiaoyao San (JWXYS) has demonstrated notable ameliorative effects on liver stagnation and spleen deficiency-type liver disease. However, its potential mechanisms are still unclear. This study aimed to explore the therapeutic mechanism of JWXYS in treating chronic liver disease by establishing a rat model induced by a high-fat diet. The results revealed that JWXYS could reduce serum levels of total cholesterol (TC) triglycerides (TG) and aspartate aminotransferase (AST) in model rats, significantly improve the structure of liver lobule, reduce lipid deposition in hepatocytes, and reduce the abundance of harmful intestinal flora (such as <em>Staphylococcus</em> and <em>Enterococcus</em>). In addition, JWXYS improved gut microbiota imbalance, regulated bile acid and lipid metabolism, and maintained the overall health of rats. These findings provide a theoretical basis for using JWXYS to treat chronic fatty liver disease.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100567"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-21DOI: 10.1016/j.aimed.2025.100561
Daniel Lopes , Alana C. Costa , Cícero A.C. Pereira , Helena P.G. Joaquim
Narcolepsy is a chronic neurological disorder that affects sleep-wake regulation and is characterized by excessive daytime sleepiness, sudden sleep episodes, cataplexy, sleep paralysis, and vivid hallucinations. While there is no cure, symptoms can be managed through pharmacological and non-pharmacological interventions. Emerging research, based on pre-clinical evidence, supports the use of cannabinoid therapies for managing narcolepsy symptoms. This case study reports on a 33-year-old Brazilian woman with narcolepsy who, after conventional treatments proved insufficient, benefited from cannabinoid therapy. Initially treated with modafinil and aripiprazole, her treatment regimen was adjusted to include a Cannabis sativa extract (CSE), allowing for a reduction in her other medications. After 5 months of treatment, she experienced significant improvements in daytime sleepiness, motivation, and ability to perform daily tasks. With the stabilization of her condition, her quality of life was enhanced. While conventional treatments are often effective, they may lose efficacy over time, necessitating dose adjustments or alternative therapies. Cannabinoid therapies have shown promise in managing sleep disorders and may represent a viable alternative for treating narcolepsy.
{"title":"Cannabis extract in treatment of narcolepsy: A case report","authors":"Daniel Lopes , Alana C. Costa , Cícero A.C. Pereira , Helena P.G. Joaquim","doi":"10.1016/j.aimed.2025.100561","DOIUrl":"10.1016/j.aimed.2025.100561","url":null,"abstract":"<div><div>Narcolepsy is a chronic neurological disorder that affects sleep-wake regulation and is characterized by excessive daytime sleepiness, sudden sleep episodes, cataplexy, sleep paralysis, and vivid hallucinations. While there is no cure, symptoms can be managed through pharmacological and non-pharmacological interventions. Emerging research, based on pre-clinical evidence, supports the use of cannabinoid therapies for managing narcolepsy symptoms. This case study reports on a 33-year-old Brazilian woman with narcolepsy who, after conventional treatments proved insufficient, benefited from cannabinoid therapy. Initially treated with modafinil and aripiprazole, her treatment regimen was adjusted to include a Cannabis sativa extract (CSE), allowing for a reduction in her other medications. After 5 months of treatment, she experienced significant improvements in daytime sleepiness, motivation, and ability to perform daily tasks. With the stabilization of her condition, her quality of life was enhanced. While conventional treatments are often effective, they may lose efficacy over time, necessitating dose adjustments or alternative therapies. Cannabinoid therapies have shown promise in managing sleep disorders and may represent a viable alternative for treating narcolepsy.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100561"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-21DOI: 10.1016/j.aimed.2025.100564
Md Manzar Alam , Mustehasan , Usama Akram , Mumtaz Ahmad , N. Zaheer Ahmed
Background
Nanotechnology is an emerging technology which is a game changer for various fields of discipline like medicine, biotechnology, material sciences, and environmental sciences. This is about controlling materials on a nanoscale, where at least one dimension is less than 100 nm (a nanometer). Such technology may lead to smart materials that can be used in construction and other fields.
Objective
To investigate the relationship between nanotechnology and Unani medicine, examining knowledge of nanoscale materials in classical Unani literature and their modern applications in nanomedicine.
Methods
This was done by a narrative review of classical Unani medical writings, and a comprehensive search of scientific databases such as Google Scholar, PubMed, ScienceDirect, and Web of Science up to October 2023. The contributions of scholars including Jābir ibn Ḥayyān (Geber), Zakariyyā Rāzī (Rhazes), Shamsuddīn Undulusī and Ḥakīm Ajmal Khān are reviewed here, particularly their observations on the maximum particle size of a drug intended for medicinal purposes. For example, nanoparticle synthesis techniques such as photolysis, co-precipitation, sol-gel, electrochemical precipitation, and green chemistry were examined due to their implications regarding present nanotechnology.
Results
This study demonstrates that ancient Unani scholars had knowledge of therapeutic potential of metal-based nanoparticles specifically through the use of Kushta (calx) and Sayyāl (dissolved metals) in their medicinal formulations. Such practices are aligned with contemporary nanotechnological principles. The review further elaborates on current approaches of nanoparticles synthesis that mirror traditional Unani methods, especially in the regard of eco-friendly approaches including chemistry green.
Conclusion
This study provides an insight into nanotech being a part of Unani medicine far earlier than modern-day practices, with Kushtasāzī (calcination) and Sayyāl being potential forerunners to modern nanotechnology. However, the adoption of modern nanotechnological techniques into the well-established Unani system leads to tremendous innovation and establishes a link between ancient wisdom and recently developed advanced therapeutic approaches.
Funding statement
This work received no specific funding from any external funding agencies. The study was performed in the Regional Research Institute of Unani Medicine, Patna, using institutional resources and facilities.
纳米技术是一项新兴技术，它改变了医学、生物技术、材料科学和环境科学等各个学科领域的游戏规则。这是关于在纳米尺度上控制材料，其中至少有一个维度小于100 nm（纳米）。这种技术可能会产生可用于建筑和其他领域的智能材料。目的探讨纳米技术与纳米医学的关系，考察经典文献中纳米材料的知识及其在纳米医学中的现代应用。方法通过对经典乌干达医学著作的叙述性回顾，以及对谷歌Scholar、PubMed、ScienceDirect和Web of Science等科学数据库的全面搜索，完成了这项研究，截止到2023年10月。本文回顾了Jābir ibn Ḥayyān （Geber）、zakariyyi Rāzī （Rhazes）、shamsudd n undulusi和Ḥakīm Ajmal Khān等学者的贡献，特别是他们对用于医疗目的的药物的最大粒径的观察。例如，纳米粒子合成技术，如光解、共沉淀、溶胶-凝胶、电化学沉淀和绿色化学，由于它们对当前纳米技术的影响而被研究。结果本研究表明，古代Unani学者通过在其药物配方中使用Kushta （calx）和Sayyāl（溶解金属），了解了金属基纳米颗粒的治疗潜力。这些实践与当代纳米技术原理是一致的。综述进一步阐述了目前反映传统Unani方法的纳米颗粒合成方法，特别是在包括化学绿色在内的生态友好方法方面。结论该研究提供了纳米技术作为Unani医学的一部分的见解，其时间远早于现代实践，Kushtasāzī（煅烧）和Sayyāl是现代纳米技术的潜在先驱。然而，将现代纳米技术应用到完善的Unani系统中导致了巨大的创新，并在古代智慧和最近开发的先进治疗方法之间建立了联系。本工作未获得任何外部资助机构的具体资助。这项研究是在巴特那的乌纳尼医学区域研究所进行的，利用了机构的资源和设施。
{"title":"Nanotechnology in the Unani system of medicine: A comprehensive review and hypothesis","authors":"Md Manzar Alam , Mustehasan , Usama Akram , Mumtaz Ahmad , N. Zaheer Ahmed","doi":"10.1016/j.aimed.2025.100564","DOIUrl":"10.1016/j.aimed.2025.100564","url":null,"abstract":"<div><h3>Background</h3><div>Nanotechnology is an emerging technology which is a game changer for various fields of discipline like<!--> <!-->medicine, biotechnology, material sciences, and environmental sciences. This is about controlling materials on a nanoscale,<!--> <!-->where at least one dimension is less than 100 nm (a nanometer). Such technology may lead to smart materials that can be used in construction and other fields.</div></div><div><h3>Objective</h3><div>To investigate the relationship between nanotechnology and Unani medicine, examining knowledge of nanoscale<!--> <!-->materials in classical Unani literature and their modern applications in nanomedicine.</div></div><div><h3>Methods</h3><div>This was done by a narrative review of classical Unani medical<!--> <!-->writings, and a comprehensive search of scientific databases such as Google Scholar, PubMed, ScienceDirect, and Web of Science up to October 2023. The contributions of scholars including <em>Jābir<!--> <!-->ibn Ḥayyān</em> (Geber), <em>Zakariyyā Rāzī</em> (Rhazes), <em>Shamsuddīn Undulusī</em> and <em>Ḥakīm Ajmal Khān</em> are reviewed here, particularly their observations on the maximum particle size of a drug intended for medicinal purposes. For example, nanoparticle synthesis techniques such as photolysis, co-precipitation, sol-gel, electrochemical precipitation, and green<!--> <!-->chemistry were examined due to their implications regarding present nanotechnology.</div></div><div><h3>Results</h3><div>This study demonstrates that ancient Unani scholars had knowledge of therapeutic potential of metal-based nanoparticles specifically through the use of <em>Kushta</em> (calx) and<!--> <em>Sayyāl</em> (dissolved metals) in their medicinal formulations. Such practices are aligned with contemporary<!--> <!-->nanotechnological principles. The review further elaborates on current approaches of nanoparticles synthesis that mirror traditional Unani methods, especially in the regard of eco-friendly approaches including chemistry<!--> <!-->green.</div></div><div><h3>Conclusion</h3><div>This study provides<!--> <!-->an insight into nanotech being a part of Unani medicine far earlier than modern-day practices, with <em>Kushtasāzī</em> (calcination) and <em>Sayyāl</em> being potential forerunners to modern nanotechnology. However, the adoption of<!--> <!-->modern nanotechnological techniques into the well-established Unani system leads to tremendous innovation and establishes a link between ancient wisdom and recently developed advanced therapeutic approaches.</div></div><div><h3>Funding statement</h3><div>This work received no specific funding from any external funding agencies. The study was performed in the Regional Research Institute of Unani Medicine, Patna, using institutional resources and facilities.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100564"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Post-traumatic stress disorder (PTSD) is a growing concern worldwide. The increasing incidence of PTSD, compounded by the social stigma associated with it, often prevents individuals from seeking professional help. The objective of this study was to develop, validate, and test the feasibility of Tele-Yoga Module (TYM) for managing PTSD, within a community setting in India.
Methods
The TYM was developed and validated following the procedure presented in the protocol study [1]. The feasibility of the module was then tested in a 12-week study with sixty participants diagnosed with PTSD as per DSM-V criteria. Participants were split evenly between the TYM and a treatment-as-usual (TAU) group. We measured variables such as PTSD symptoms, social functioning, resilience, anxiety, depression, and yoga-based personality traits.
Results
Participants in the TYM group showed significant improvements in PTSD symptoms, anxiety, and depression, compared to the TAU group (p < 0.001 for all). No significant between-group differences were observed in resilience and psycho-social functions (p = 0.11). The feasibility aspects of the TYM have been discussed under seven dimensions, including safety and acceptability. These findings suggest that the TYM can serve as a potentially useful add-on intervention in managing PTSD. This study contributes to the emerging field of tele-yoga and highlights the importance of culturally and contextually adapted mental health interventions. Such approaches are crucial for addressing the global burden of PTSD.
{"title":"Development, validation, and feasibility testing of Tele-Yoga Module for PTSD","authors":"Naresh Katla , Judu Ilavarasu , Ramesh Mavathur , Hemant Bhargav , Bharath Holla , Vinod Kumar , Atmika Y. Ramsahaye , Arun Thulasi , Syed Zaeem Haider Zaidi","doi":"10.1016/j.aimed.2025.100562","DOIUrl":"10.1016/j.aimed.2025.100562","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-traumatic stress disorder (PTSD) is a growing concern worldwide. The increasing incidence of PTSD, compounded by the social stigma associated with it, often prevents individuals from seeking professional help. The objective of this study was to develop, validate, and test the feasibility of Tele-Yoga Module (TYM) for managing PTSD, within a community setting in India.</div></div><div><h3>Methods</h3><div>The TYM was developed and validated following the procedure presented in the protocol study <span><span>[1]</span></span>. The feasibility of the module was then tested in a 12-week study with sixty participants diagnosed with PTSD as per DSM-V criteria. Participants were split evenly between the TYM and a treatment-as-usual (TAU) group. We measured variables such as PTSD symptoms, social functioning, resilience, anxiety, depression, and yoga-based personality traits.</div></div><div><h3>Results</h3><div>Participants in the TYM group showed significant improvements in PTSD symptoms, anxiety, and depression, compared to the TAU group (<em>p</em> < 0.001 for all). No significant between-group differences were observed in resilience and psycho-social functions (<em>p</em> = 0.11). The feasibility aspects of the TYM have been discussed under seven dimensions, including safety and acceptability. These findings suggest that the TYM can serve as a potentially useful add-on intervention in managing PTSD. This study contributes to the emerging field of tele-yoga and highlights the importance of culturally and contextually adapted mental health interventions. Such approaches are crucial for addressing the global burden of PTSD.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100562"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Numerous studies have demonstrated that a significant number of individuals experience weight regain following bariatric surgery. To sustain long-term weight loss outcomes, it is imperative to assist patients in adopting and maintaining healthy lifestyle changes. Implementing cognitive interventions aimed at enhancing self-management behaviors is crucial in supporting patients' efforts to sustain weight loss post-surgery.
Materials and methods
This paper outlines a protocol for a randomized controlled trial with two arms. The sample will consist of 100 patients who have undergone bariatric surgery and are part of the Tehran Obesity Treatment Study. The participants will be randomly assigned to either the intervention group or the control group. The intervention group will receive an educational intervention based on the health action process approach for a duration of eight weeks. The inclusion criteria for this study are patients who have undergone bariatric surgery at least one year prior to the study. All primary and secondary outcomes will be measured at two different time points: baseline and four months after the completion of the intervention, for each participant.
Conclusion
The results of this study offer valuable insights into the advantages of theory-based educational interventions in improving outcomes of bariatric surgery. These findings present an opportunity for health planners, practitioners, nurses specializing in bariatric surgery care, policy makers, and patients to utilize an effective intervention in the field.
{"title":"Effect of an intervention grounded in the health action process approach on obesity surgery outcomes among bariatric surgery patients after one year: A randomized-controlled trial protocol","authors":"Elham Shakibazadeh, Maryam Maghsoodlo, Mehdi Yaseri, Zeinab Mokhtari, Maryam Barzin, Yahya Salimi","doi":"10.1016/j.aimed.2025.100565","DOIUrl":"10.1016/j.aimed.2025.100565","url":null,"abstract":"<div><h3>Background</h3><div>Numerous studies have demonstrated that a significant number of individuals experience weight regain following bariatric surgery. To sustain long-term weight loss outcomes, it is imperative to assist patients in adopting and maintaining healthy lifestyle changes. Implementing cognitive interventions aimed at enhancing self-management behaviors is crucial in supporting patients' efforts to sustain weight loss post-surgery.</div></div><div><h3>Materials and methods</h3><div>This paper outlines a protocol for a randomized controlled trial with two arms. The sample will consist of 100 patients who have undergone bariatric surgery and are part of the Tehran Obesity Treatment Study. The participants will be randomly assigned to either the intervention group or the control group. The intervention group will receive an educational intervention based on the health action process approach for a duration of eight weeks. The inclusion criteria for this study are patients who have undergone bariatric surgery at least one year prior to the study. All primary and secondary outcomes will be measured at two different time points: baseline and four months after the completion of the intervention, for each participant.</div></div><div><h3>Conclusion</h3><div>The results of this study offer valuable insights into the advantages of theory-based educational interventions in improving outcomes of bariatric surgery. These findings present an opportunity for health planners, practitioners, nurses specializing in bariatric surgery care, policy makers, and patients to utilize an effective intervention in the field.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100565"},"PeriodicalIF":1.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-25DOI: 10.1016/j.aimed.2025.100559
Eliza Mara das Chagas Paiva , Caroline de Castro Moura , Natália da Silva Martins Fonseca , Ana Cláudia Mesquita Garcia
Objective
Auricular acupuncture (AA) is a promising intervention for managing chemotherapy-induced nausea and vomiting (CINV). However, most randomized clinical trials (RCTs) have methodological limitations and a significant risk of bias, making the evidence inconclusive. This pilot study aimed to assess the feasibility of an AA protocol for controlling CINV in adult cancer patients.
Methods
This was a pilot study of a parallel, two-arm, blinded RCT with a 1:1 allocation ratio. Participants were randomized into two study arms: the AA group, which received true auricular acupuncture, or the sham AA group. The evaluated outcomes included preliminary evaluation of the effectiveness of the intervention for the occurrence of CINV, adverse effects of the intervention and study feasibility.
Results
Among the participants assessed for eligibility, 50 patients were randomized into the study arms, with 70 % of final evaluations completed. Thirty-five participants completed the study between January and July 2023. No serious adverse events occurred. A significant difference was observed between the AA and sham groups regarding nausea after the last chemotherapy session at follow-up (p = 0.005), suggesting a potential benefit of the intervention.
Conclusion
This pilot study demonstrated the feasibility of conducting an RCT on AA for CINV control, highlighting challenges in recruitment and adherence. Preliminary findings suggest that AA is safe and generally associated with few adverse events, which were transient and mild in intensity. These findings reinforce the need for a definitive RCT to confirm efficacy and support the integration of AA into clinical practice.
Trial registration
This study is registered in the Brazilian Registry of Clinical Trials (ReBEC): RBR-5rp37x8.
{"title":"Auricular acupuncture for chemotherapy-induced nausea and vomiting: A pilot study of a blinded randomized clinical trial","authors":"Eliza Mara das Chagas Paiva , Caroline de Castro Moura , Natália da Silva Martins Fonseca , Ana Cláudia Mesquita Garcia","doi":"10.1016/j.aimed.2025.100559","DOIUrl":"10.1016/j.aimed.2025.100559","url":null,"abstract":"<div><h3>Objective</h3><div>Auricular acupuncture (AA) is a promising intervention for managing chemotherapy-induced nausea and vomiting (CINV). However, most randomized clinical trials (RCTs) have methodological limitations and a significant risk of bias, making the evidence inconclusive. This pilot study aimed to assess the feasibility of an AA protocol for controlling CINV in adult cancer patients.</div></div><div><h3>Methods</h3><div>This was a pilot study of a parallel, two-arm, blinded RCT with a 1:1 allocation ratio. Participants were randomized into two study arms: the AA group, which received true auricular acupuncture, or the sham AA group. The evaluated outcomes included preliminary evaluation of the effectiveness of the intervention for the occurrence of CINV, adverse effects of the intervention and study feasibility.</div></div><div><h3>Results</h3><div>Among the participants assessed for eligibility, 50 patients were randomized into the study arms, with 70 % of final evaluations completed. Thirty-five participants completed the study between January and July 2023. No serious adverse events occurred. A significant difference was observed between the AA and sham groups regarding nausea after the last chemotherapy session at follow-up (p = 0.005), suggesting a potential benefit of the intervention.</div></div><div><h3>Conclusion</h3><div>This pilot study demonstrated the feasibility of conducting an RCT on AA for CINV control, highlighting challenges in recruitment and adherence. Preliminary findings suggest that AA is safe and generally associated with few adverse events, which were transient and mild in intensity. These findings reinforce the need for a definitive RCT to confirm efficacy and support the integration of AA into clinical practice.</div></div><div><h3>Trial registration</h3><div>This study is registered in the Brazilian Registry of Clinical Trials (ReBEC): RBR-5rp37x8.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100559"},"PeriodicalIF":1.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-24DOI: 10.1016/j.aimed.2025.100557
Marianna E. Kapsetaki
Background
Career success can be influenced by many factors. Could these include name characteristics?
Methods
In this study, online sources were used to collect biographical information and bibliometrics of all consultant paediatric surgeons working in the United Kingdom (N = 192). Excel formulas and online name analysis tools were used to collect many forename and surname characteristics.
Results
Shorter forenames were associated with having graduated from a top university for their medical degree, having a higher academic age and h-index, and more citations. Those who graduated from a non-top university for their medical degree had a longer number of consequent consonants in their surname. The number of consonant sequences in the first name was higher in those currently affiliated with a top university. A higher consonant-to-vowel ratio was found in paediatric surgeons who a) are currently affiliated with a non-top university (this was found only for the forename), b) had graduated from a top university for their medical degree or started publishing early following medical school graduation (these were found only for the surname). Those with an initial plosive in the forename had more first author publications, whereas those with an initial plosive in the surname were more likely to have graduated from a non-top university for their PhD. Paediatric surgeons with more popular names were more likely to have obtained their medical degree from the United Kingdom.
Conclusion
This study revealed that associations exist between certain name characteristics of consultant paediatric surgeons in the United Kingdom and their career success.
{"title":"Do name characteristics influence the career success of UK paediatric surgeons?","authors":"Marianna E. Kapsetaki","doi":"10.1016/j.aimed.2025.100557","DOIUrl":"10.1016/j.aimed.2025.100557","url":null,"abstract":"<div><h3>Background</h3><div>Career success can be influenced by many factors. Could these include name characteristics?</div></div><div><h3>Methods</h3><div>In this study, online sources were used to collect biographical information and bibliometrics of all consultant paediatric surgeons working in the United Kingdom (N = 192). Excel formulas and online name analysis tools were used to collect many forename and surname characteristics.</div></div><div><h3>Results</h3><div>Shorter forenames were associated with having graduated from a top university for their medical degree, having a higher academic age and h-index, and more citations. Those who graduated from a non-top university for their medical degree had a longer number of consequent consonants in their surname. The number of consonant sequences in the first name was higher in those currently affiliated with a top university. A higher consonant-to-vowel ratio was found in paediatric surgeons who a) are currently affiliated with a non-top university (this was found only for the forename), b) had graduated from a top university for their medical degree or started publishing early following medical school graduation (these were found only for the surname). Those with an initial plosive in the forename had more first author publications, whereas those with an initial plosive in the surname were more likely to have graduated from a non-top university for their PhD. Paediatric surgeons with more popular names were more likely to have obtained their medical degree from the United Kingdom.</div></div><div><h3>Conclusion</h3><div>This study revealed that associations exist between certain name characteristics of consultant paediatric surgeons in the United Kingdom and their career success.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100557"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-23DOI: 10.1016/j.aimed.2025.100558
Deeksha P. Shetty , Neetinakumar J Patil , G. Shyamala , Vijetha Shenoy Belle , K. Annapoorna , R. Vani Lakshmi , Hemant Bhargav , Rajeshkrishna Bhandary , Anice George
Aim
This study aims to evaluate the effectiveness of a six-month yoga intervention in managing primary dysmenorrhea and its associated symptoms—including menstrual pain, psychological well-being (depression, anxiety, and stress), sleep quality, and overall quality of life—in young women.
Methods
A longitudinal study was conducted with 20 women aged 18–25 years diagnosed with primary dysmenorrhea. Participants were randomly assigned to either an intervention group practising yoga or a control group engaging in moderate walking. The yoga intervention was conducted for six months, with sessions held five days a week. Pain intensity (VAS), psychological outcomes (DASS-21), sleep quality (PSQI), and quality of life (WHOQOL) were assessed at baseline, 3 months, and 6 months. Statistical analyses included repeated measures ANOVA to assess changes over time and between-group differences.
Results
Significant improvements were observed in the intervention group compared to the control group. Pain scores were significantly lower in the yoga group at 3 months (Mean Difference = 2.30, p = 0.020) and 6 months (Mean Difference = 2.80, p < 0.001). Psychological outcomes also improved, with reductions in depression (p < 0.001), anxiety (p < 0.001), and stress (p = 0.002). Sleep quality showed moderate improvements, but between-group differences were not statistically significant. Quality of life improved over time, particularly in the intervention group (p = 0.024).
Conclusion
This study highlights the potential benefits of yoga as a non-pharmacological intervention for primary dysmenorrhea. Regular yoga practice significantly reduces pain, improves mental well-being, and enhances overall quality of life. These findings support the integration of yoga into holistic treatment approaches for menstrual health management.
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Pub Date : 2025-07-15DOI: 10.1016/j.aimed.2025.100556
Poovitha Shruthi Paramashiva , Suresh Sukumar , Dilip Shettigar , Rajagopal Kadavigere , Abhimanyu Pradhan , Nitika C. Panakkal , Winniecia Dkhar , K. Vaishali , Baskaran Chandrasekaran , Hari Prakash Palaniswamy , Sneha Ravichandran , Sathya Sabina Muthu , Koustubh Kamath , Haris Jose Felix , Anam Shazli , Leena R. David
Background
Sedentary behaviour negatively impacts vascular function, increasing cardiovascular risk. While yoga and conventional exercise are proposed to counteract these effects, their relative efficacy remains unclear.
Objective
This review aims to compare the effects of yoga and conventional exercise interventions on ultrasound-measured vascular function in sedentary individuals.
Methods
A systematic search of PubMed, Scopus, and Web of Science was conducted (last updated February 15, 2025), including randomized controlled trials (RCTs), crossover trials, and non-randomized studies comparing yoga and exercise interventions in sedentary adults. Studies assessing vascular function using ultrasound techniques (e.g., flow-mediated dilation [FMD], pulse wave velocity [PWV]) were included. The review followed PRISMA guidelines and was registered in PROSPERO (CRD420250655130).
Results
Ten studies met the inclusion criteria. Yoga interventions showed mixed results, with some improvement in endothelial function in older adults but inconsistent effects on arterial stiffness. Exercise interventions consistently improved FMD and reduced arterial stiffness. However, micro-breaks during prolonged sitting yielded limited benefits. Most studies had small sample sizes and short durations, affecting generalizability.
Conclusion
Exercise interventions consistently improve vascular function more than yoga among sedentary individuals. Yoga may benefit older populations but lacks
久坐行为会对血管功能产生负面影响，增加心血管风险。虽然人们建议瑜伽和传统运动来抵消这些影响，但它们的相对功效尚不清楚。目的本综述旨在比较瑜伽和常规运动干预对久坐人群超声测量血管功能的影响。方法系统检索PubMed、Scopus和Web of Science（最近更新于2025年2月15日），包括随机对照试验（rct）、交叉试验和非随机研究，比较瑜伽和运动干预对久坐成年人的影响。包括使用超声技术评估血管功能的研究（例如，血流介导的扩张[FMD]，脉冲波速度[PWV]）。该审查遵循PRISMA指南，并在PROSPERO注册（CRD420250655130）。结果10项研究符合纳入标准。瑜伽干预的结果好坏参半，老年人的内皮功能有所改善，但对动脉僵硬的影响不一致。运动干预持续改善FMD和减少动脉僵硬。然而，在长时间坐着的时候，微休息带来的好处有限。大多数研究样本量小，持续时间短，影响了普遍性。结论运动干预对久坐人群血管功能的改善效果优于瑜伽。瑜伽可能对老年人有益，但缺乏益处
{"title":"Comparing the effects of yoga and exercise on vascular function: A systematic review","authors":"Poovitha Shruthi Paramashiva , Suresh Sukumar , Dilip Shettigar , Rajagopal Kadavigere , Abhimanyu Pradhan , Nitika C. Panakkal , Winniecia Dkhar , K. Vaishali , Baskaran Chandrasekaran , Hari Prakash Palaniswamy , Sneha Ravichandran , Sathya Sabina Muthu , Koustubh Kamath , Haris Jose Felix , Anam Shazli , Leena R. David","doi":"10.1016/j.aimed.2025.100556","DOIUrl":"10.1016/j.aimed.2025.100556","url":null,"abstract":"<div><h3>Background</h3><div>Sedentary behaviour negatively impacts vascular function, increasing cardiovascular risk. While yoga and conventional exercise are proposed to counteract these effects, their relative efficacy remains unclear.</div></div><div><h3>Objective</h3><div>This review aims to compare the effects of yoga and conventional exercise interventions on ultrasound-measured vascular function in sedentary individuals.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Scopus, and Web of Science was conducted (last updated February 15, 2025), including randomized controlled trials (RCTs), crossover trials, and non-randomized studies comparing yoga and exercise interventions in sedentary adults. Studies assessing vascular function using ultrasound techniques (e.g., flow-mediated dilation [FMD], pulse wave velocity [PWV]) were included. The review followed PRISMA guidelines and was registered in PROSPERO (CRD420250655130).</div></div><div><h3>Results</h3><div>Ten studies met the inclusion criteria. Yoga interventions showed mixed results, with some improvement in endothelial function in older adults but inconsistent effects on arterial stiffness. Exercise interventions consistently improved FMD and reduced arterial stiffness. However, micro-breaks during prolonged sitting yielded limited benefits. Most studies had small sample sizes and short durations, affecting generalizability.</div></div><div><h3>Conclusion</h3><div>Exercise interventions consistently improve vascular function more than yoga among sedentary individuals. Yoga may benefit older populations but lacks</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100556"},"PeriodicalIF":1.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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