Advances in integrative medicine最新文献_第10页

Efficacy and safety of polyherbal formulation in the management of acne vulgaris: An open label, baseline-controlled, single center, prospective clinical trial 复方制剂治疗寻常痤疮的疗效和安全性：一项开放标签、基线对照、单中心、前瞻性临床试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-04-22 DOI: 10.1016/j.aimed.2025.100490

Kailash Chandra , Shaikh Khursheed Aalam , Anish Murtaja Alam Khan , Sanjay Londhe , Subodh P. Sirur , Mahendra Chaudhari , Yadnyesh Pandit , Asad Mueed , Rajeev Ranjan , Shashank Agarwal , Santosh Kumar Joshi

Background

Acne vulgaris, a common skin condition, presents a significant challenge in clinical management. This prospective baseline-controlled clinical trial aimed to evaluate the therapeutic efficacy and safety of SAFI syrup, an Indian traditional polyherbal formulation, for the treatment of acne vulgaris.

Materials and methods

Two hundred fifty subjects were initially enrolled and 213 excluded based on inclusion and exclusion criteria. Biochemical analysis was performed at baseline, and 3 subjects were excluded due to abnormal laboratory results. Thirty-four subjects received SAFI syrup treatment and were assessed at various time points over 90 days.

Results

The study found that SAFI syrup treatment was well-tolerated, with no statistically significant differences in safety parameters (serum ALT, AST, creatinine and BUN) between baseline and 90 days (p > 0.05). Neutrophil levels decreased significantly during treatment (p 0.04). In terms of acne grading, most patients exhibited moderate to severe acne at the beginning, but after 90 days of SAFI treatment, the majority of study subjects showed significant improvement (P < 0.001), with several achieved acne grades of 0. Leaky gut analysis revealed a substantial reduction in leaky gut scores (p 0.001), indicating improved gut health in most subjects.

Conclusion

This 90-days interventional study suggests that SAFI syrup, a polyherbal formulation, is an effective and safe option for managing acne vulgaris. The treatment resulted in significant improvements in acne grading scores, leaky gut analysis, and laboratory parameters of efficacy and safety. These findings support the use of SAFI Syrup as a viable treatment for acne vulgaris, providing a potential solution for this challenging skin condition.

寻常痤疮是一种常见的皮肤疾病，在临床治疗中提出了重大挑战。本前瞻性基线对照临床试验旨在评估SAFI糖浆治疗寻常痤疮的疗效和安全性，SAFI糖浆是一种印度传统的多草药配方。材料和方法最初纳入250名受试者，根据纳入和排除标准排除213名受试者。基线生化分析，因实验室结果异常排除3例。34名受试者接受SAFI糖浆治疗，并在90天内的不同时间点进行评估。结果研究发现，SAFI糖浆治疗耐受性良好，安全性参数（血清ALT、AST、肌酐和BUN）在基线和90天之间无统计学差异（p >； 0.05）。治疗期间中性粒细胞水平显著降低（p 0.04）。在痤疮分级方面，大多数患者在开始时表现为中度至重度痤疮，但经过90天的SAFI治疗后，大多数研究对象的痤疮均有显著改善（P <； 0.001），有几个患者的痤疮分级达到0级。漏肠分析显示，漏肠评分显著降低（p 0.001），表明大多数受试者的肠道健康得到改善。结论本90天的介入研究表明，复方SAFI糖浆治疗寻常性痤疮是一种安全有效的选择。治疗结果显著改善痤疮分级评分，漏肠分析，有效性和安全性的实验室参数。这些发现支持使用SAFI糖浆作为治疗寻常痤疮的可行方法，为这种具有挑战性的皮肤状况提供了潜在的解决方案。

{"title":"Efficacy and safety of polyherbal formulation in the management of acne vulgaris: An open label, baseline-controlled, single center, prospective clinical trial","authors":"Kailash Chandra , Shaikh Khursheed Aalam , Anish Murtaja Alam Khan , Sanjay Londhe , Subodh P. Sirur , Mahendra Chaudhari , Yadnyesh Pandit , Asad Mueed , Rajeev Ranjan , Shashank Agarwal , Santosh Kumar Joshi","doi":"10.1016/j.aimed.2025.100490","DOIUrl":"10.1016/j.aimed.2025.100490","url":null,"abstract":"<div><h3>Background</h3><div>Acne vulgaris, a common skin condition, presents a significant challenge in clinical management. This prospective baseline-controlled clinical trial aimed to evaluate the therapeutic efficacy and safety of SAFI syrup, an Indian traditional polyherbal formulation, for the treatment of acne vulgaris.</div></div><div><h3>Materials and methods</h3><div>Two hundred fifty subjects were initially enrolled and 213 excluded based on inclusion and exclusion criteria. Biochemical analysis was performed at baseline, and 3 subjects were excluded due to abnormal laboratory results. Thirty-four subjects received SAFI syrup treatment and were assessed at various time points over 90 days.</div></div><div><h3>Results</h3><div>The study found that SAFI syrup treatment was well-tolerated, with no statistically significant differences in safety parameters (serum ALT, AST, creatinine and BUN) between baseline and 90 days (p > 0.05). Neutrophil levels decreased significantly during treatment (p 0.04). In terms of acne grading, most patients exhibited moderate to severe acne at the beginning, but after 90 days of SAFI treatment, the majority of study subjects showed significant improvement (<em>P < 0.001)</em>, with several achieved acne grades of 0. Leaky gut analysis revealed a substantial reduction in leaky gut scores (p 0.001), indicating improved gut health in most subjects.</div></div><div><h3>Conclusion</h3><div>This 90-days interventional study suggests that SAFI syrup, a polyherbal formulation, is an effective and safe option for managing acne vulgaris. The treatment resulted in significant improvements in acne grading scores, leaky gut analysis, and laboratory parameters of efficacy and safety. These findings support the use of SAFI Syrup as a viable treatment for acne vulgaris, providing a potential solution for this challenging skin condition.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100490"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Artificial intelligence versus human analysis: Interpreting data in elderly fat reduction study” [Adv. Integr. Med. 12 (1) (2025) 13–18] “人工智能与人类分析：解读老年人减脂研究数据”的勘误表[综合编辑]。Med. 12 (1) (2025) 13-18]

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-04-22 DOI: 10.1016/j.aimed.2025.100488

Mariusz Konieczny, Piotr Sporek

引用次数: 0

Development, validation, and feasibility of integrated Yoga module for Internet Gaming Disorder among adolescents 青少年网络游戏障碍综合瑜伽模块的开发、验证和可行性

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-04-17 DOI: 10.1016/j.aimed.2025.100486

Nagalakshmi S. Rao , Raghavendra Bhat , Manoj Kumar Sharma , Alaka Mani T L

Background

Internet gaming is a popular leisure activity among adolescents, but excessive use can lead to Internet Gaming Disorder (IGD). IGD has been associated with negative health outcomes, including increased stress, obesity, decreased academic performance, and mental health issues. To address this, we developed a Yoga module leveraging Yoga’s known health benefits as a potential intervention for IGD.

Methods

The study was conducted in three stages. In the first stage, the Yoga module was developed by a scientific and traditional literature review on Yoga, followed by group discussion with five Yoga experts and one psychiatrist. In the second stage, the developed module was sent to 45 Yoga experts, out of which 25 experts provided feedback. The Lawshe’s Content Validity Ratio(CVR)method was used for the content validity of the Yoga module. Stage three, feasibility study was conducted using randomized controlled trial. Thirty subjects were randomly allocated to Yoga (n = 15) and control group (n = 15). They were assessed after one month of intervention.

Results

Thirty Yoga practices (30 out of 34) with Lawshe’s Content Validity ratio ≥ 0.37 were retained (88 %) in the final Yoga Module.The pilot study demonstrated a significant difference by Independent sample t-test comparing the Yoga group and Control group in the variable WHO Quality of Life (QOL) – Social (P < 0.05) d = 0.951, Loneliness (P < 0.001), d = 2.396, Mind Wandering (P < 0.05), d = 0.839 and Parental Internet Gaming Disorder(P < 0.001), d = 3.014.

Conclusion

The present study offers a validated Yoga module for adolescents with IGD. The pilot study suggests that the module is feasible and easy to practice. To gain maximum benefits, we recommend that this module be practiced at least three times a week (40 min each session) under the supervision of a Yoga expert.

网络游戏是青少年中流行的休闲活动，但过度使用会导致网络游戏障碍（IGD）。IGD与负面健康结果有关，包括压力增加、肥胖、学习成绩下降和心理健康问题。为了解决这个问题，我们开发了一个瑜伽模块，利用瑜伽已知的健康益处作为IGD的潜在干预措施。方法本研究分三个阶段进行。在第一阶段，瑜伽模块是通过对瑜伽的科学和传统文献的回顾来开发的，然后是与五位瑜伽专家和一位精神科医生进行小组讨论。在第二阶段，开发的模块被发送给45位瑜伽专家，其中25位专家提供了反馈。瑜伽模块的内容效度采用Lawshe 's Content Validity Ratio（CVR）法。第三阶段，采用随机对照试验进行可行性研究。30名受试者随机分为瑜伽组（n = 15）和对照组（n = 15）。他们在干预一个月后接受评估。结果在最终的瑜伽模块中，保留了Lawshe内容效度≥ 0.37的30个瑜伽练习（88 %）。初步研究通过独立样本t检验比较瑜伽组和对照组在可变的WHO生活质量(QOL) -社会(P <；0.05) d = 0.951，孤独(P <；0.001), d = 2.396，走神(P <；0.05), d = 0.839，父母网络游戏障碍(P <；0.001), d = 3.014。结论本研究为青少年IGD患者提供了一个有效的瑜伽模块。初步研究表明，该模块是可行的，易于实践。为了获得最大的好处，我们建议在瑜伽专家的指导下，每周至少练习三次（每次40 分钟）。

{"title":"Development, validation, and feasibility of integrated Yoga module for Internet Gaming Disorder among adolescents","authors":"Nagalakshmi S. Rao , Raghavendra Bhat , Manoj Kumar Sharma , Alaka Mani T L","doi":"10.1016/j.aimed.2025.100486","DOIUrl":"10.1016/j.aimed.2025.100486","url":null,"abstract":"<div><h3>Background</h3><div>Internet gaming is a popular leisure activity among adolescents, but excessive use can lead to Internet Gaming Disorder (IGD). IGD has been associated with negative health outcomes, including increased stress, obesity, decreased academic performance, and mental health issues. To address this, we developed a Yoga module leveraging Yoga’s known health benefits as a potential intervention for IGD.</div></div><div><h3>Methods</h3><div>The study was conducted in three stages. In the first stage, the Yoga module was developed by a scientific and traditional literature review on Yoga, followed by group discussion with five Yoga experts and one psychiatrist. In the second stage, the developed module was sent to 45 Yoga experts, out of which 25 experts provided feedback. The Lawshe’s Content Validity Ratio(CVR)method was used for the content validity of the Yoga module. Stage three, feasibility study was conducted using randomized controlled trial. Thirty subjects were randomly allocated to Yoga (n = 15) and control group (n = 15). They were assessed after one month of intervention.</div></div><div><h3>Results</h3><div>Thirty Yoga practices (30 out of 34) with Lawshe’s Content Validity ratio ≥ 0.37 were retained (88 %) in the final Yoga Module.The pilot study demonstrated a significant difference by Independent sample t-test comparing the Yoga group and Control group in the variable WHO Quality of Life (QOL) – Social (P < 0.05) d = 0.951, Loneliness (P < 0.001), d = 2.396, Mind Wandering (P < 0.05), d = 0.839 and Parental Internet Gaming Disorder(P < 0.001), d = 3.014.</div></div><div><h3>Conclusion</h3><div>The present study offers a validated Yoga module for adolescents with IGD. The pilot study suggests that the module is feasible and easy to practice. To gain maximum benefits, we recommend that this module be practiced at least three times a week (40 min each session) under the supervision of a Yoga expert.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100486"},"PeriodicalIF":1.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal plants use by patients at a Moroccan University Hospital: A cross-sectional study 摩洛哥大学医院病人使用的药用植物：一项横断面研究

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-04-17 DOI: 10.1016/j.aimed.2025.100487

El Mahdi Razzok , Hassane Mekhfi , Naima Abda , Asmae Lekfif , Najib Dahbi , Yassamine Bentata

Background

The use of medicinal plants is widespread in traditional medicines worldwide, including in Morocco, where their use depends on cultural, economic, and geographical factors. This study aims to evaluate the frequency of use of medicinal plants among patients hospitalized at the University Hospital Center of Oujda and to identify the factors associated with it, as well as to examine the impact of the COVID-19 pandemic on this use.

Methods

A cross-sectional study, conducted from April 2022 to February 2023, was conducted in the cardiology, nephrology, internal medicine, neurology, oncology, and visceral surgery departments of the Mohammed VI University Hospital Center in Oujda. All adult patients (> 18 years old), of both genders, who consented to participate in the study were included.

Results

307 patients were collected. The mean age of our patients was 52 ± 16 years, 57 % were female. 75.9 % of patients had already used medicinal plants and 46.5 % reported having consumed more during the COVID-19 pandemic. Digestive diseases, respiratory diseases, and cancer were among the main pathologies treated with these plants. The three main plants consumed were oregano in 54.7 % of cases, rosemary in 26.4 % of cases, and eucalyptus in 26.38 % of cases. The majority of patients (68.7 %) reported an improvement in their health status after consuming the plants, while 8.2 % of them had side effects, mainly gastrointestinal disorders. The consumption of plants was significantly associated with gender (p = 0.001), origin (p = 0.001) hospitalization department (p = 0.008) and history of cancer (p = 0.026).

Conclusion

This study highlights the importance of the use of medicinal plants in Morocco, especially during the COVID-19 pandemic, and emphasizes the need to act on the associated factors and to raise awareness among the population about their potential side effects.

药用植物的使用在世界各地的传统药物中很普遍，包括在摩洛哥，它们的使用取决于文化、经济和地理因素。本研究旨在评估在Oujda大学医院中心住院的患者使用药用植物的频率，并确定与之相关的因素，并研究COVID-19大流行对这种使用的影响。方法横断面研究于2022年4月至2023年2月在Oujda穆罕默德六世大学医院中心的心脏科、肾病科、内科、神经内科、肿瘤科和内脏外科进行。所有成年患者(>；18岁)，包括同意参加研究的男女。结果共收集患者307例。患者平均年龄52岁 ± 16岁，女性占57 %。75.9% %的患者已经使用过药用植物，46.5 %的患者报告在COVID-19大流行期间使用了更多的药用植物。消化系统疾病、呼吸系统疾病和癌症是用这些植物治疗的主要疾病。食用的三种主要植物是牛至（54.7% %）、迷迭香（26.4% %）和桉树（26.38% %）。大多数患者（68.7% %）报告说，食用这些植物后，他们的健康状况有所改善，而8.2% %的患者出现副作用，主要是胃肠道疾病。植物食用量与性别（p = 0.001）、产地（p = 0.001）、住院科室（p = 0.008）和癌症史（p = 0.026）显著相关。本研究强调了摩洛哥使用药用植物的重要性，特别是在2019冠状病毒病大流行期间，并强调需要针对相关因素采取行动，并提高民众对其潜在副作用的认识。

{"title":"Medicinal plants use by patients at a Moroccan University Hospital: A cross-sectional study","authors":"El Mahdi Razzok , Hassane Mekhfi , Naima Abda , Asmae Lekfif , Najib Dahbi , Yassamine Bentata","doi":"10.1016/j.aimed.2025.100487","DOIUrl":"10.1016/j.aimed.2025.100487","url":null,"abstract":"<div><h3>Background</h3><div>The use of medicinal plants is widespread in traditional medicines worldwide, including in Morocco, where their use depends on cultural, economic, and geographical factors. This study aims to evaluate the frequency of use of medicinal plants among patients hospitalized at the University Hospital Center of Oujda and to identify the factors associated with it, as well as to examine the impact of the COVID-19 pandemic on this use.</div></div><div><h3>Methods</h3><div>A cross-sectional study, conducted from April 2022 to February 2023, was conducted in the cardiology, nephrology, internal medicine, neurology, oncology, and visceral surgery departments of the Mohammed VI University Hospital Center in Oujda. All adult patients (> 18 years old), of both genders, who consented to participate in the study were included.</div></div><div><h3>Results</h3><div>307 patients were collected. The mean age of our patients was 52 ± 16 years, 57 % were female. 75.9 % of patients had already used medicinal plants and 46.5 % reported having consumed more during the COVID-19 pandemic. Digestive diseases, respiratory diseases, and cancer were among the main pathologies treated with these plants. The three main plants consumed were oregano in 54.7 % of cases, rosemary in 26.4 % of cases, and eucalyptus in 26.38 % of cases. The majority of patients (68.7 %) reported an improvement in their health status after consuming the plants, while 8.2 % of them had side effects, mainly gastrointestinal disorders. The consumption of plants was significantly associated with gender (p = 0.001), origin (p = 0.001) hospitalization department (p = 0.008) and history of cancer (p = 0.026).</div></div><div><h3>Conclusion</h3><div>This study highlights the importance of the use of medicinal plants in Morocco, especially during the COVID-19 pandemic, and emphasizes the need to act on the associated factors and to raise awareness among the population about their potential side effects.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100487"},"PeriodicalIF":1.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Glycyrrhiza glabra on peptic ulcer disease: A systematic review and meta-analysis 甘草对消化性溃疡疾病的疗效：系统回顾和荟萃分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-04-16 DOI: 10.1016/j.aimed.2025.100485

Elham Zaeif Khorasani , Tahereh Amirian , Ebrahim Nasiri Formi , Fatemeh Mahjoub , Masoumeh Sadeghi

Introduction

Peptic ulcer is a common gastrointestinal disorder, marked by lesions in the mucosal lining of the stomach and duodenum. Due to the limitations of conventional treatments, herbal medicines have gained wide popularity for treating digestive conditions. The current study aims to conduct a systematic review and meta-analysis to assess the effects of licorice on peptic ulcers.

Methods

A comprehensive search was performed in online databases, including PubMed, Web of Science, Scopus, Cochrane, and Embase, covering publications up to 7 August 2024, using relevant keywords. Ultimately, 9 studies, comprising a total of 618 participants, had the eligibility criteria. In the statistical analysis, binary data were analyzed using odds ratios (OR) with 95 % confidence intervals (CIs). To evaluate statistical heterogeneity across studies, the I2 statistic was calculated.

Results

These studies reported clinical improvement in peptic ulcer symptoms (stomach and duodenal ulcers) and radiographic and endoscopic evidence of complete healing lesion or reduction in size. Some of them demonstrated licorice’s positive effects on ulcer healing, while others found no significant difference compared to placebo. The pooled odds ratio for clinical symptom improvement in pain was calculated to be 0.52 (95 % CI: 0.42–1.45), and for complete ulcer healing, it was 0.60 (95 % CI: 0.24–1.43), indicating that these findings were not statistically significant.

Conclusions

While the intervention demonstrated a trend toward improved clinical symptoms and healing in peptic ulcers compared to placebo, the lack of statistical significance and the observed heterogeneity highlight the need for further research to clarify these effects

消化性溃疡是一种常见的胃肠道疾病，以胃和十二指肠粘膜损伤为特征。由于传统治疗方法的局限性，草药在治疗消化系统疾病方面得到了广泛的普及。本研究旨在通过系统回顾和荟萃分析来评估甘草对消化性溃疡的影响。方法综合检索PubMed、Web of Science、Scopus、Cochrane、Embase等数据库，检索截止到2024年8月7日的出版物，并使用相关关键词进行检索。最终，共有618名参与者的9项研究符合资格标准。在统计分析中，二元数据采用比值比（OR）进行分析，比值比为95 %置信区间（ci）。为了评估研究间的统计异质性，计算I2统计量。结果这些研究报告了消化性溃疡症状（胃和十二指肠溃疡）的临床改善，以及x线和内镜下病变完全愈合或缩小的证据。其中一些研究表明，甘草对溃疡愈合有积极作用，而另一些研究发现，与安慰剂相比，甘草没有显著差异。计算疼痛临床症状改善的合并优势比为0.52(95 % CI: 0.42-1.45)，溃疡完全愈合的合并优势比为0.60(95 % CI: 0.24-1.43)，表明这些发现无统计学意义。结论：虽然与安慰剂相比，干预显示出改善消化性溃疡临床症状和愈合的趋势，但缺乏统计学意义和观察到的异质性突出表明需要进一步研究来阐明这些效果

{"title":"Efficacy of Glycyrrhiza glabra on peptic ulcer disease: A systematic review and meta-analysis","authors":"Elham Zaeif Khorasani , Tahereh Amirian , Ebrahim Nasiri Formi , Fatemeh Mahjoub , Masoumeh Sadeghi","doi":"10.1016/j.aimed.2025.100485","DOIUrl":"10.1016/j.aimed.2025.100485","url":null,"abstract":"<div><h3>Introduction</h3><div>Peptic ulcer is a common gastrointestinal disorder, marked by lesions in the mucosal lining of the stomach and duodenum. Due to the limitations of conventional treatments, herbal medicines have gained wide popularity for treating digestive conditions. The current study aims to conduct a systematic review and meta-analysis to assess the effects of licorice on peptic ulcers.</div></div><div><h3>Methods</h3><div>A comprehensive search was performed in online databases, including PubMed, Web of Science, Scopus, Cochrane, and Embase, covering publications up to 7 August 2024, using relevant keywords. Ultimately, 9 studies, comprising a total of 618 participants, had the eligibility criteria. In the statistical analysis, binary data were analyzed using odds ratios (OR) with 95 % confidence intervals (CIs). To evaluate statistical heterogeneity across studies, the I2 statistic was calculated.</div></div><div><h3>Results</h3><div>These studies reported clinical improvement in peptic ulcer symptoms (stomach and duodenal ulcers) and radiographic and endoscopic evidence of complete healing lesion or reduction in size. Some of them demonstrated licorice’s positive effects on ulcer healing, while others found no significant difference compared to placebo. The pooled odds ratio for clinical symptom improvement in pain was calculated to be 0.52 (95 % CI: 0.42–1.45), and for complete ulcer healing, it was 0.60 (95 % CI: 0.24–1.43), indicating that these findings were not statistically significant.</div></div><div><h3>Conclusions</h3><div>While the intervention demonstrated a trend toward improved clinical symptoms and healing in peptic ulcers compared to placebo, the lack of statistical significance and the observed heterogeneity highlight the need for further research to clarify these effects</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100485"},"PeriodicalIF":1.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Shuneez (Nigella sativa) as galactogogue on mothers complaining of insufficient breast milk: A single-blind clinical trial 催乳剂对母乳不足母亲的影响：一项单盲临床试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-04-11 DOI: 10.1016/j.aimed.2025.100481

Samreen Khan , M. Anas , Diwan Israr Khan , Deeba Khanam

Despite the fact that exclusive breastfeeding has many health advantages for both mother and baby, only a small percentage of mothers actually adhere to this ideal practise leaving majority of infants without access to it. Most mothers (roughly 30–80 %) who stop exclusive breastfeeding for the first half year of baby's life complain about insufficient milk production. Therefore, this study was conducted on 100 mothers enrolled from Obstetrics and Paediatrics OPD of dept. of Amraze-Niswan wa Atfal Ajmal Khan Tibbiya College and Maternity Ward of Jawahar Lal Nehru Medical College, AMU, Aligarh from March 2021 to September 2022 on mothers complaining of insufficient breast milk secretion having child not more than a month in the absence of any systemic disease to the mother and her baby.The effect of the test drug on maternal serum prolactin and neonatal anthropometric measures (weight, length and head circumference) was significant with P < 0.0001. Furthermore, it did not exert any adverse effect on maternal Hb, ALT, AST, ALP and S. creatinine (‘P’values 0.9178, 0.3146, 0.2242, 0.3282, 0.7320 respectively) and found safe on the above parameters.Therefore, it has been concluded from the study that the test drug (Nigella sativa) was effective and safe in enhancing breast milk secretion.

尽管纯母乳喂养对母亲和婴儿的健康都有许多好处，但只有一小部分母亲真正坚持这种理想的做法，使大多数婴儿无法获得母乳喂养。在婴儿生命的前半年停止纯母乳喂养的大多数母亲（大约30 - 80% %）抱怨产奶量不足。因此，本研究于2021年3月至2022年9月对来自Amraze-Niswan wa Atfal Ajmal Khan Tibbiya学院产科和儿科OPD和Jawahar Lal Nehru医学院产科病房的100名母亲进行了研究，这些母亲抱怨母乳分泌不足不超过一个月，母亲和婴儿没有任何全身性疾病。试验药物对产妇血清催乳素及新生儿体重、身长、头围的影响有统计学意义，P值为 <； 0.0001。对孕妇Hb、ALT、AST、ALP和S.肌酐均无不良影响（P值分别为0.9178、0.3146、0.2242、0.3282、0.7320），对上述参数均安全。因此，本研究认为试验药物黑草（Nigella sativa）对促进母乳分泌是安全有效的。

{"title":"The effect of Shuneez (Nigella sativa) as galactogogue on mothers complaining of insufficient breast milk: A single-blind clinical trial","authors":"Samreen Khan , M. Anas , Diwan Israr Khan , Deeba Khanam","doi":"10.1016/j.aimed.2025.100481","DOIUrl":"10.1016/j.aimed.2025.100481","url":null,"abstract":"<div><div>Despite the fact that exclusive breastfeeding has many health advantages for both mother and baby, only a small percentage of mothers actually adhere to this ideal practise leaving majority of infants without access to it. Most mothers (roughly 30–80 %) who stop exclusive breastfeeding for the first half year of baby's life complain about insufficient milk production. Therefore, this study was conducted on 100 mothers enrolled from Obstetrics and Paediatrics OPD of dept. of Amraze-Niswan wa Atfal Ajmal Khan Tibbiya College and Maternity Ward of Jawahar Lal Nehru Medical College, AMU, Aligarh from March 2021 to September 2022 on mothers complaining of insufficient breast milk secretion having child not more than a month in the absence of any systemic disease to the mother and her baby.The effect of the test drug on maternal serum prolactin and neonatal anthropometric measures (weight, length and head circumference) was significant with P < 0.0001. Furthermore, it did not exert any adverse effect on maternal Hb, ALT, AST, ALP and S. creatinine (‘P’values 0.9178, 0.3146, 0.2242, 0.3282, 0.7320 respectively) and found safe on the above parameters.Therefore, it has been concluded from the study that the test drug <em>(Nigella sativa</em>) was effective and safe in enhancing breast milk secretion.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 2","pages":"Article 100481"},"PeriodicalIF":1.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yoga versus transdiagnostic cognitive behavioural therapy for emotional disorders in community-dwelling adults: Study protocol for a non-inferiority randomised controlled trial 瑜伽与跨诊断认知行为疗法治疗社区成人情绪障碍：一项非劣效性随机对照试验的研究方案

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-04-02 DOI: 10.1016/j.aimed.2025.100484

Danielle C. Mathersul , Jean M. Byrne , Joyce J.Y. Lau , Robert M. Schütze , Yvonne C. Learmonth , Hakuei Fujiyama , Kristin Naragon-Gainey , Peter M. McEvoy , Peter J. Bayley

Cognitive behavioural therapy (CBT) is the first-line non-pharmacological intervention for the most prevalent and co-occurring mental health conditions (anxiety, major depressive, posttraumatic stress, and alcohol use disorders). However, CBT response rates are variable and access is limited by cost, availability, and up-take. Yoga demonstrates efficacy for these conditions and may be more accessible than CBT. However, to better refine personalised healthcare and ensure maximum generalisability to “real-world” presentations, we need methodologically robust randomised controlled trials (RCTs) that compare yoga to appropriate controls, monitor mental health co-occurrences, and examine biomarkers and mechanisms of action alongside outcomes. We present the study protocol for an ongoing, experimenter-masked, parallel-group, non-inferiority design RCT to evaluate the efficacy of 10-week yoga (novel intervention) versus 10-week transdiagnostic CBT (the Unified Protocol; evidence-based active control) for co-occurring anxiety, major depressive, posttraumatic stress, or alcohol use disorders among community-dwelling Australian adults (aged ≥18 years). The protocol is approved by Murdoch University Human Research Ethics Committee. The primary outcome measure is the Kessler Psychological Distress Scale (weeks 0, 11, 23, 35) and power analyses determined a minimum of 67 participants per group are required to assess non-inferiority. Secondary outcomes include a clinician-administered interview, self-reported symptoms, and functional outcomes. Sleep and emotion regulation self-report measures (including ecological momentary assessment) and physiological biomarkers (actigraphy, heart rate variability) will be tested as potential moderators and mediators of outcome. Experimenter-masked analyses will use both intent-to-treat and per-protocol approaches.

Findings

will inform evidence-based formal recommendations and policy regarding the implementation of yoga into healthcare and may advance precision medicine.

认知行为疗法（CBT）是最普遍和同时发生的精神健康状况（焦虑、重度抑郁、创伤后应激和酒精使用障碍）的一线非药物干预手段。然而，CBT的响应率是可变的，并且受成本、可用性和使用率的限制。瑜伽证明了对这些疾病的疗效，可能比认知行为疗法更容易获得。然而，为了更好地完善个性化医疗保健，并确保最大限度地推广到“现实世界”的演示，我们需要方法学上可靠的随机对照试验（rct），将瑜伽与适当的对照进行比较，监测心理健康的共同发生情况，并检查生物标志物和作用机制以及结果。我们提出了一项正在进行的、实验者隐藏的、平行组、非劣效性设计的随机对照试验的研究方案，以评估10周瑜伽（新干预）与10周跨诊断CBT(统一方案；循证主动控制)在澳大利亚社区居住成年人（年龄≥18岁）中共同发生的焦虑、重度抑郁、创伤后应激或酒精使用障碍。本协议经莫道克大学人类研究伦理委员会批准。主要结果测量是Kessler心理困扰量表（第0、11、23、35周），功率分析确定每组至少需要67名参与者来评估非劣效性。次要结局包括临床医生的访谈、自我报告的症状和功能结局。睡眠和情绪调节自我报告测量（包括生态瞬间评估）和生理生物标志物（活动记录仪，心率变异性）将作为结果的潜在调节和中介进行测试。实验者屏蔽分析将使用意向治疗和协议处理两种方法。研究结果将为在医疗保健中实施瑜伽的循证正式建议和政策提供信息，并可能推动精准医学的发展。

{"title":"Yoga versus transdiagnostic cognitive behavioural therapy for emotional disorders in community-dwelling adults: Study protocol for a non-inferiority randomised controlled trial","authors":"Danielle C. Mathersul , Jean M. Byrne , Joyce J.Y. Lau , Robert M. Schütze , Yvonne C. Learmonth , Hakuei Fujiyama , Kristin Naragon-Gainey , Peter M. McEvoy , Peter J. Bayley","doi":"10.1016/j.aimed.2025.100484","DOIUrl":"10.1016/j.aimed.2025.100484","url":null,"abstract":"<div><div>Cognitive behavioural therapy (CBT) is the first-line non-pharmacological intervention for the most prevalent and co-occurring mental health conditions (anxiety, major depressive, posttraumatic stress, and alcohol use disorders). However, CBT response rates are variable and access is limited by cost, availability, and up-take. Yoga demonstrates efficacy for these conditions and may be more accessible than CBT. However, to better refine personalised healthcare and ensure maximum generalisability to “real-world” presentations, we need methodologically robust randomised controlled trials (RCTs) that compare yoga to appropriate controls, monitor mental health co-occurrences, and examine biomarkers and mechanisms of action alongside outcomes. We present the study protocol for an ongoing, experimenter-masked, parallel-group, non-inferiority design RCT to evaluate the efficacy of 10-week yoga (novel intervention) versus 10-week transdiagnostic CBT (the <em>Unified Protocol</em>; evidence-based active control) for co-occurring anxiety, major depressive, posttraumatic stress, or alcohol use disorders among community-dwelling Australian adults (aged ≥18 years). The protocol is approved by Murdoch University Human Research Ethics Committee. The primary outcome measure is the Kessler Psychological Distress Scale (weeks 0, 11, 23, 35) and power analyses determined a minimum of 67 participants per group are required to assess non-inferiority. Secondary outcomes include a clinician-administered interview, self-reported symptoms, and functional outcomes. Sleep and emotion regulation self-report measures (including ecological momentary assessment) and physiological biomarkers (actigraphy, heart rate variability) will be tested as potential moderators and mediators of outcome. Experimenter-masked analyses will use both intent-to-treat and per-protocol approaches.</div></div><div><h3>Findings</h3><div>will inform evidence-based formal recommendations and policy regarding the implementation of yoga into healthcare and may advance precision medicine.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100484"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation, and clinical efficacy of Zataria multiflora Boiss. capsules in mild to moderate Alzheimer disease: A double-blind randomized trial 何首乌的配方及临床疗效观察。胶囊治疗轻至中度阿尔茨海默病：一项双盲随机试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-03-31 DOI: 10.1016/j.aimed.2025.100483

Mehdi Ansari , Kosar Sargazi-Moghadam , Haleh Tajadini , Mohadese Kamali , Hoda Kamali , Tania Dehesh , Reyhane Shojaei , Fariba Sharififar

Objective

Alzheimer’s disease (AD), the leading cause of dementia, is a major contributor to disability among older adults, and effective treatments remain a significant challenge. Recent studies suggest that Zataria multiflora has antioxidant, anticholinesterase, and memory-enhancing capabilities. This study investigates the potential of edible plant capsules derived from Z. multiflora to reduce clinical symptoms in patients with mild to moderate AD.

Methods

A randomized, double-blind, placebo-controlled clinical trial was conducted in a Kerman nursing home between November 2019 and February 2020. Herbal capsules were formulated using a standardized extract of Z. multiflora with rigorous quality control. Seventy-two eligible participants (over 50 years old) were randomly assigned to either the intervention or placebo groups using randomized replacement blocks. The intervention group received 600 mg of the herbal capsules three times daily, while the placebo group received an identical placebo, both for 8 weeks. The primary outcomes were memory improvements, measured using Clinical Dementia Rating (CDR) and Mini-Mental State Examination (MMSE) scores at baseline, week 4, and week 8. Data was analyzed using SPSS version 23 with independent t-tests, chi-square, and Fisher’s exact tests for group comparisons. A significance level of p < 0.05 was used.

Results

Both groups showed statistically significant changes in mean CDR and MMSE scores from baseline to week 4, week 8, and also from week 4 to week 8. However, the intervention group had significantly greater improvements than the placebo group. A significant time-group interaction was observed in both CDR and MMSE assessments.

Conclusion

Despite the relatively short intervention period, which warrants further longer-term studies, the observed improvements in CDR and MMSE scores suggest that Z. multiflora may be a promising adjunctive treatment for individuals with AD. These findings support further research into the therapeutic potential of Z. multiflora in this context.

阿尔茨海默病（AD）是痴呆症的主要病因，也是老年人残疾的主要原因，有效的治疗仍然是一个重大挑战。最近的研究表明，何首乌具有抗氧化、抗胆碱酯酶和增强记忆的能力。本研究探讨了从何根草中提取的可食用植物胶囊对减轻轻至中度AD患者临床症状的潜力。方法于2019年11月至2020年2月在克尔曼养老院进行随机、双盲、安慰剂对照临床试验。中药胶囊的配方采用标准的何首乌提取物，并进行严格的质量控制。72名符合条件的参与者（50岁以上）被随机分配到干预组或安慰剂组，使用随机替代块。干预组每天三次服用600 毫克的草药胶囊，而安慰剂组则服用相同的安慰剂，疗程均为8周。主要结果是记忆改善，在基线、第4周和第8周使用临床痴呆评分（CDR）和迷你精神状态检查（MMSE）评分进行测量。数据分析使用SPSS 23版，采用独立t检验、卡方检验和Fisher精确检验进行组间比较。采用p <； 0.05的显著性水平。结果两组患者的平均CDR和MMSE评分从基线到第4周、第8周以及从第4周到第8周均有统计学意义的变化。然而，干预组明显比安慰剂组有更大的改善。在CDR和MMSE评估中观察到显著的时间组相互作用。结论：尽管干预期相对较短，需要进一步的长期研究，但观察到的CDR和MMSE评分的改善表明，多菌根可能是一种有希望的AD患者辅助治疗方法。这些发现支持在此背景下进一步研究多菌根的治疗潜力。

{"title":"Formulation, and clinical efficacy of Zataria multiflora Boiss. capsules in mild to moderate Alzheimer disease: A double-blind randomized trial","authors":"Mehdi Ansari , Kosar Sargazi-Moghadam , Haleh Tajadini , Mohadese Kamali , Hoda Kamali , Tania Dehesh , Reyhane Shojaei , Fariba Sharififar","doi":"10.1016/j.aimed.2025.100483","DOIUrl":"10.1016/j.aimed.2025.100483","url":null,"abstract":"<div><h3>Objective</h3><div>Alzheimer’s disease (AD), the leading cause of dementia, is a major contributor to disability among older adults, and effective treatments remain a significant challenge. Recent studies suggest that <em>Zataria multiflora</em> has antioxidant, anticholinesterase, and memory-enhancing capabilities. This study investigates the potential of edible plant capsules derived from <em>Z. multiflora</em> to reduce clinical symptoms in patients with mild to moderate AD.</div></div><div><h3>Methods</h3><div>A randomized, double-blind, placebo-controlled clinical trial was conducted in a Kerman nursing home between November 2019 and February 2020. Herbal capsules were formulated using a standardized extract of <em>Z. multiflora</em> with rigorous quality control. Seventy-two eligible participants (over 50 years old) were randomly assigned to either the intervention or placebo groups using randomized replacement blocks. The intervention group received 600 mg of the herbal capsules three times daily, while the placebo group received an identical placebo, both for 8 weeks. The primary outcomes were memory improvements, measured using Clinical Dementia Rating (CDR) and Mini-Mental State Examination (MMSE) scores at baseline, week 4, and week 8. Data was analyzed using SPSS version 23 with independent t-tests, chi-square, and Fisher’s exact tests for group comparisons. A significance level of p < 0.05 was used.</div></div><div><h3>Results</h3><div>Both groups showed statistically significant changes in mean CDR and MMSE scores from baseline to week 4, week 8, and also from week 4 to week 8. However, the intervention group had significantly greater improvements than the placebo group. A significant time-group interaction was observed in both CDR and MMSE assessments.</div></div><div><h3>Conclusion</h3><div>Despite the relatively short intervention period, which warrants further longer-term studies, the observed improvements in CDR and MMSE scores suggest that <em>Z. multiflora</em> may be a promising adjunctive treatment for individuals with AD. These findings support further research into the therapeutic potential of <em>Z. multiflora</em> in this context.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100483"},"PeriodicalIF":1.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardization of herbal medicine use: A global imperative for safety, efficacy, and public health 草药使用标准化：安全性、有效性和公共卫生的全球当务之急

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-03-28 DOI: 10.1016/j.aimed.2025.100482

Emad M. Abdallah, Wael E. Abdalla, Alaa M.M. Sadeek

引用次数: 0

Investigating the effects of applying low acoustic frequencies on the pain from venous and arterial blood sampling: A clinical trial study 研究应用低频率对静脉和动脉采血疼痛的影响：一项临床试验研究

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-03-28 DOI: 10.1016/j.aimed.2025.100480

Saeed Mohammadi , Ebrahim Ezzati , Rooghaye Mahooti , Fatemeh Kavyannejad , Mohammad Sadegh Paran , Rasoul Kavyannejad

Background

The pain of the blood sampling process is an unpleasant and common experience in the treatment process. Stimulation the thalamus structure and corticothalamic pathways with at specific frequencies could play a role in modulating pain perception. The aim of this study was to investigate the use low acoustic frequencies in reducing pain during arterial and venous blood sampling.

Material and Methods

In a triple-blinded clinical trial study, 300 patients in each process were randomly divided into control and intervention groups. Patients in the intervention groups received sound frequencies of 10–200 Hz with an intensity of 50 dB during the procedures. Pain intensity, heart rate changes, number of attempts for successful sampling, and time required for each procedure were measured. Data were analyzed using Prism 10 software.

Results

Pain levels were significantly lower in the intervention groups with increasing sound frequencies in both procedures (P < 0.05). The duration of blood sampling procedures was significantly shorter with increasing sound frequency (P < 0.05), but no difference was observed in the frequency of sampling attempts (P > 0.05). By increasing the sound frequency, the intensity of tachycardia significantly decreased following the blood sampling process (P < 0.05), especially at higher frequencies.

Conclusion

Applying low sound frequencies effectively could reduce acute pain and its consequences resulting from an invasive process. Sound frequencies appear to play a role in modulating pain pathways in the central nervous system.

Implications for Clinical Practice

The study findings suggest that sound frequency ranges as a non-pharmacological analgesia intervention can be used to reduce pain and discomfort following a variety of blood sampling procedures, which performed by nurses.

采血过程中的疼痛是治疗过程中令人不愉快且常见的经历。以特定频率刺激丘脑结构和皮质丘脑通路可能在调节痛觉中起作用。本研究的目的是探讨在动脉和静脉血取样时使用低声波来减轻疼痛。材料与方法采用三盲临床试验研究，每个过程300例患者随机分为对照组和干预组。干预组患者在手术过程中接受的声音频率为10-200 Hz，强度为50 dB。测量疼痛强度、心率变化、成功取样的尝试次数和每个过程所需的时间。数据分析采用Prism 10软件。结果两种手术中随着声音频率的增加，干预组的西班牙水平均显著降低（P <； 0.05）。随着声音频率的增加，血液采样过程的持续时间显著缩短（P <； 0.05），但在采样尝试的频率上没有观察到差异（P <； 0.05）。通过增加声音频率，在采血过程中心动过速的强度显著降低（P <； 0.05），特别是在较高的频率。结论低频率应用能有效减轻创伤过程中急性疼痛及其后果。声音频率似乎在调节中枢神经系统的疼痛通路中起作用。对临床实践的启示研究结果表明，声音频率范围作为一种非药物镇痛干预措施，可用于减轻由护士执行的各种血液采样程序后的疼痛和不适。

{"title":"Investigating the effects of applying low acoustic frequencies on the pain from venous and arterial blood sampling: A clinical trial study","authors":"Saeed Mohammadi , Ebrahim Ezzati , Rooghaye Mahooti , Fatemeh Kavyannejad , Mohammad Sadegh Paran , Rasoul Kavyannejad","doi":"10.1016/j.aimed.2025.100480","DOIUrl":"10.1016/j.aimed.2025.100480","url":null,"abstract":"<div><h3>Background</h3><div>The pain of the blood sampling process is an unpleasant and common experience in the treatment process. Stimulation the thalamus structure and corticothalamic pathways with at specific frequencies could play a role in modulating pain perception. The aim of this study was to investigate the use low acoustic frequencies in reducing pain during arterial and venous blood sampling.</div></div><div><h3>Material and Methods</h3><div>In a triple-blinded clinical trial study, 300 patients in each process were randomly divided into control and intervention groups. Patients in the intervention groups received sound frequencies of 10–200 Hz with an intensity of 50 dB during the procedures. Pain intensity, heart rate changes, number of attempts for successful sampling, and time required for each procedure were measured. Data were analyzed using Prism 10 software.</div></div><div><h3>Results</h3><div>Pain levels were significantly lower in the intervention groups with increasing sound frequencies in both procedures (P < 0.05). The duration of blood sampling procedures was significantly shorter with increasing sound frequency (P < 0.05), but no difference was observed in the frequency of sampling attempts (P > 0.05). By increasing the sound frequency, the intensity of tachycardia significantly decreased following the blood sampling process (P < 0.05), especially at higher frequencies.</div></div><div><h3>Conclusion</h3><div>Applying low sound frequencies effectively could reduce acute pain and its consequences resulting from an invasive process. Sound frequencies appear to play a role in modulating pain pathways in the central nervous system.</div></div><div><h3>Implications for Clinical Practice</h3><div>The study findings suggest that sound frequency ranges as a non-pharmacological analgesia intervention can be used to reduce pain and discomfort following a variety of blood sampling procedures, which performed by nurses.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100480"},"PeriodicalIF":1.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0