Advances in integrative medicine最新文献_第2页

Profile of patients presenting to Australian osteopaths: Results from a national health service use survey 澳大利亚整骨治疗师的患者概况：来自全国卫生服务使用调查的结果

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-11-20 DOI: 10.1016/j.aimed.2025.100590

Brett Vaughan , Michael Fleischmann , Niklas Sinderholm Sposato , Jerry Draper-Rodi , Kesava Kovanur Sampath , Loïc Treffel , Cindy McIntyre , Chantal Morin , Lee Muddle , Oliver P. Thomson

Background and purpose

Musculoskeletal conditions are one of the most common complaints affecting the Australian population. Affected individuals often seek care from a range of health professionals including osteopaths. Osteopaths provide care for musculoskeletal conditions using manual therapy, exercise, and patient education. The current study is a secondary analysis of data from an Australian health service use survey.

Materials & methods

Respondents were asked to indicate the range of health professionals they consulted during the period February 2021 and February 2022. Additional data collected from respondents related to demographic variables, presence of chronic conditions in addition to the Personal Wellbeing Index (PWI) and Short Form 20 (SF-20). Data were descriptively analysed based on whether the respondent reported consulting with an osteopath or not.

Results

In the period February 2021-February 2022, of the 2354 respondents, 143 (6.1 %) indicated they had consulted with an osteopath. Over half of those who consulted with an osteopath identified as female (51.7 %), had private health insurance (59.4 %) and/or a healthcare card (69.9 %). No significant difference was observed between respondents who consulted with an osteopath and those who did not for PWI scores (p > 0.05). SF-20 scores were significantly lower for those who consulted with an osteopath compared with those who did not (p < 0.01).

Conclusion

This secondary analysis contributes to our understanding of the profile of patients presenting to Australian osteopaths, particularly health related quality of life and subjective wellbeing of this patient cohort.

背景和目的肌肉骨骼疾病是影响澳大利亚人口最常见的疾病之一。受影响的个人经常向包括整骨医生在内的一系列卫生专业人员寻求治疗。整骨医生通过手工治疗、锻炼和病人教育来治疗肌肉骨骼疾病。目前的研究是对澳大利亚卫生服务使用调查数据的二次分析。材料和方法受访者被要求说明他们在2021年2月至2022年2月期间咨询的卫生专业人员的范围。除了个人幸福指数（PWI）和SF-20短表之外，还从受访者那里收集了与人口统计变量、慢性病存在相关的其他数据。根据受访者是否报告咨询整骨医生，对数据进行描述性分析。结果在2021年2月至2022年2月期间，2354名受访者中，143名（6.1 %）表示曾咨询过整骨治疗师。超过一半咨询整骨医生的人（51.7 %）拥有私人医疗保险（59.4 %）和/或医疗卡（69.9% %）。在接受整骨治疗的受访者与未接受整骨治疗的受访者之间，PWI评分无显著差异（p >； 0.05）。与未咨询整骨医生的患者相比，咨询整骨医生的SF-20评分明显较低（p <； 0.01）。结论：这一次要分析有助于我们了解澳大利亚整骨治疗师患者的概况，特别是与健康相关的生活质量和该患者队列的主观幸福感。

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引用次数: 0

Investigating the effect of traditional Persian manual technique on pain and disability in patients with chronic low back pain: A randomized controlled clinical trial 研究传统波斯手法对慢性腰痛患者疼痛和残疾的影响：一项随机对照临床试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-11-17 DOI: 10.1016/j.aimed.2025.100589

Mohammad Taghi Rezaipour , Fatemeh Nejatbakhsh , Younes Roohani , Mohammad Sadegh Adel-Mehraban , Alireza Abbassian

Background and purpose

Chronic low back pain (CLBP) is a significant health issue that negatively affects quality of life. Given the high recurrence rate of CLBP and patients' reluctance to undergo invasive treatments, Persian Medicine offers a manual technique for pain management. This study aimed to evaluate the efficacy of a Persian Medicine-based manual technique to treat patients with CLBP.

Materials and methods

This randomized controlled trial was performed among 108 patients with CLBP referred to Tehran University of Medical Sciences outpatient clinic from July to December 2024. Participants were randomly assigned to two groups (using block randomization) to receive either Persian Medicine or a sham manual technique simulating the original technique. Each patient received the intervention in a single session, and pain severity and disability were assessed using the Visual Analog Scale (VAS) and the Roland-Morris Disability Questionnaire (RMDQ) at four time points. Data were analyzed using SPSS v16 software with repeated-measures ANOVA.

Results

Half of the patients were male, with a mean age of 46.93 years. There was no significant difference in baseline characteristics, except for age and marital status, which did not affect study outcomes. The intervention group significantly reduced pain severity (MD: −3.1, 95 %CI: −3.92 to −2.27) (P < 0.001) and improved RMDQ scores (P < 0.001) (MD: −4.72, 95 %CI: −6.52 to −2.91) with lower recurrence rate, compared to the sham group (MD: −0.3, 95 %CI: −0.92 to +0.32, and MD: −0.9, 95 %CI: −3.02 to +1.22, respectively). No adverse effects were reported.

Conclusion

The Persian Medicine manual technique may be considered a complementary treatment for patients with CLBP, providing effective pain relief and improvement in disability.

背景与目的慢性腰痛（CLBP）是影响生活质量的重要健康问题。鉴于CLBP的高复发率和患者不愿接受侵入性治疗，波斯医学提供了一种手动疼痛管理技术。本研究旨在评估波斯医学为基础的手工技术治疗CLBP患者的疗效。材料与方法本随机对照试验于2024年7月至12月在德黑兰医科大学门诊就诊的108例CLBP患者中进行。参与者被随机分配到两组（使用块随机化），接受波斯医学或模拟原始技术的假手工技术。每位患者接受一次干预，并在四个时间点使用视觉模拟量表（VAS）和Roland-Morris残疾问卷（RMDQ）评估疼痛严重程度和残疾。数据分析采用SPSS v16软件，采用重复测量方差分析。结果半数患者为男性，平均年龄46.93岁。除了年龄和婚姻状况外，基线特征没有显著差异，这对研究结果没有影响。与假手术组（MD: - 0.3, 95 %CI: - 0.92至+0.32,MD: - 0.9, 95 %CI: - 3.02至+1.22）相比，干预组显著降低了疼痛严重程度（MD: - 3.1, 95 %CI: - 3.92至- 2.27）（P <； 0.001），改善了RMDQ评分（P <； 0.001）（MD: - 4.72, 95 %CI: - 6.52至- 2.91），复发率较低。无不良反应报告。结论波斯医学手册技术可作为CLBP患者的一种辅助治疗方法，可有效缓解疼痛和改善残疾。

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引用次数: 0

Yoga for mitigating cardiovascular risk and psychological implications of overweight and obesity: Study protocol for a randomized controlled trial 瑜伽减轻心血管风险和超重和肥胖的心理影响：一项随机对照试验的研究方案

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-11-13 DOI: 10.1016/j.aimed.2025.100588

Kiriti Bhushan Ghosh , Vijaya Majumdar , Amit Kumar Singh , Apar Avinash Saoji

Background

Overweight and obesity are common risk factors for cardiovascular events. Yoga is useful in overweight, obesity, and cardiovascular diseases. However, empirical studies on yoga to mitigate cardiovascular risk factors are lacking. Therefore, the current trial aimed to evaluate the effect of yoga on cardiovascular risk in overweight and obese individuals.

Methods

A total of 110 overweight and obese participants will be randomized into yoga (n = 55) and waitlist control (n = 55) groups. Specific yoga interventions will be administered for a duration of three months. Soluble urokinase plasminogen activator receptor (suPAR) and high-sensitivity C-reactive protein (hsCRP) are the primary markers of cardiovascular risk. Secondary outcomes will include body weight, body mass index (BMI), anthropometric measures, lipid profile, and psychological measures. Data will be analysed using relevant statistical tests.

Expected outcomes

We hypothesize that yoga will attenuate cardiovascular risk in overweight and obese individuals, which may be illustrated by biomarkers such as suPAR, hsCRP, and other markers.

背景：超重和肥胖是心血管事件的常见危险因素。瑜伽对超重、肥胖和心血管疾病都很有用。然而，关于瑜伽减轻心血管危险因素的实证研究缺乏。因此，目前的试验旨在评估瑜伽对超重和肥胖个体心血管风险的影响。方法将110名超重和肥胖参与者随机分为瑜伽组（n = 55）和候补组（n = 55）。具体的瑜伽干预将持续三个月。可溶性尿激酶纤溶酶原激活物受体（suPAR）和高敏c反应蛋白（hsCRP）是心血管危险的主要标志。次要结局包括体重、身体质量指数（BMI）、人体测量、血脂和心理测量。数据将使用相关的统计检验进行分析。预期结果：我们假设瑜伽可以降低超重和肥胖人群的心血管风险，这可以通过生物标志物如suPAR、hsCRP和其他标志物来证明。

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引用次数: 0

Extended reality in acupuncture-related research and practice: A bibliometric analysis 针灸相关研究与实践的延伸现实：文献计量学分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-22 DOI: 10.1016/j.aimed.2025.100586

Jing He

Purpose

In recent years, the application of extended reality (XR) technology in acupuncture-related research and practice has gained increasing popularity. This article aimed to conduct a bibliometric analysis in this field.

Methods

Publications between 1996 and 2024 in this field were searched in Web of Science Core Collection and Scopus. Software used for data preprocessing and analysis included Microsoft Excel, RStudio, CiteSpace, and VOSviewer.

Results

A total of 143 articles were selected. Publications in this field were increasing rapidly. The top three countries by publication volume were China, the United States and Canada. The top three most-cited countries were the United States, Belgium and China. The overall cooperation network was loose and mainly dominated by China, the United States, and the United Kingdom. The top three affiliations by publication volume were University of Toronto, Emory University, and Southern Medical University. KU Leuven had the highest total and average citations. The author with the most publications and total citations was Moseley G. The source with the most publications was Frontiers in Neurology, whereas the top cited source was Frontiers in Human Neuroscience. Hatem SM (Front Hum Neurosci, 2016) was the top cited publication with the highest average annual citation rate. The most frequent keywords included “virtual reality”, “acupuncture”, “cognitive behavioral therapy”, “stroke” and “pain”. Keyword clusters mainly focused on three aspects: neurological rehabilitation, mental health and pain management. An isolated sub-cluster existed in mental health cluster with “simulation” as its core keyword.

Conclusion

As a specialized domain, the field is expected to progress by forging a more direct integration of XR with acupuncture and a deeper convergence of basic science and clinical practice, indicating substantial progress in the future.

目的近年来，扩展现实（XR）技术在针灸相关研究和实践中的应用越来越受欢迎。本文旨在对这一领域进行文献计量分析。方法检索Web of Science Core Collection和Scopus中1996 ~ 2024年间该领域的论文。用于数据预处理和分析的软件包括Microsoft Excel、RStudio、CiteSpace和VOSviewer。结果共入选文献143篇。这一领域的出版物正在迅速增加。出版数量排名前三的国家分别是中国、美国和加拿大。被引用最多的三个国家是美国、比利时和中国。整体合作网络较为松散，以中、美、英为主。按出版数量排名前三的大学分别是多伦多大学、埃默里大学和南方医科大学。鲁汶大学的总引用量和平均引用量最高。发表文章和总被引次数最多的作者是Moseley G.发表文章最多的来源是Frontiers in Neurology，而被引次数最多的来源是Frontiers in Human Neuroscience。《Hatem SM》（Front Hum Neurosci, 2016）是被引次数最多的出版物，年平均被引率最高。最常见的关键词包括“虚拟现实”、“针灸”、“认知行为疗法”、“中风”和“疼痛”。关键词聚类主要集中在神经康复、心理健康和疼痛管理三个方面。心理健康集群中存在一个以“模拟”为核心关键词的孤立子集群。结论作为一个专业领域，该领域有望进一步发展，使其与针灸的结合更加直接，基础科学与临床实践的融合更加深入，未来将取得实质性进展。

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引用次数: 0

Prevalence of Vitamin-D deficiency and respiratory tract infections in adults: A cross-sectional study 成人维生素d缺乏和呼吸道感染的患病率：一项横断面研究

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-22 DOI: 10.1016/j.aimed.2025.100587

Karin Ried , Avni Sali

Objectives

To assess the prevalence of Vitamin-D deficiency and respiratory illnesses in Australian adults.

Methods

In a cross-sectional sample of Australian adults, serum Vitamin-D levels and frequency of cold and flu symptoms were assessed. Those with sub-optimal Vitamin-D levels (<75nmol/L) were supplied with 4000–10,000IU Vitamin-D3 daily for 3-months. Data was analyzed with ANOVA and Pearson-correlation.

Results

A total of 199 adults aged 57 ± 15 years participated in the study. A third (34 %) had optimal Vitamin-D levels at baseline, 42 % were insufficient (<75nmol/L), 19 % deficient (<50nmol/L) and 5 % severely-deficient (<25nmol/L). About half (56 %) had regularly taken Vitamin-D supplements (1000–5000IU/day) prior to the study.

The prevalence of respiratory illnesses was slightly higher (70 %, mean=3-per-year) in the severely-deficient-group compared to other Vitamin-D-groups (50 %, mean 2.5 ± 2).

Overall, the frequency of respiratory illnesses tended to be lower with higher Vitamin-D levels (group 3: r = -0.285; p = 0.009).

A total of 66 participants (50 %) with sub-optimal Vitamin-D levels (n = 131) completed Vitamin-D3 supplementation. After 3-months, no participants were Vitamin-D deficient, only 15 % remained insufficient, while 85 % reached optimal Vitamin-D levels (mean 97 ± 4nmol/L).

Conclusion

Optimal Vitamin-D levels are correlated with the prevention of respiratory illnesses, and can be achieved with Vitamin-D supplementation within 3-months.

Implications for public health

A large proportion of Australians are Vitamin-D deficient/insufficient. Vitamin-D supplementation is key to alleviate Vitamin-D deficiency and support Vitamin-D’s role in the prevention of acute respiratory infections via the innate and adaptive immune system.

目的评估澳大利亚成年人维生素d缺乏症和呼吸系统疾病的患病率。方法对澳大利亚成年人的横断面样本进行血清维生素d水平和感冒和流感症状频率的评估。维生素d水平低于最佳水平（75nmol/L）的人每天服用4000-10,000IU维生素d3，持续3个月。数据分析采用方差分析和pearson相关分析。结果共有199名年龄为57岁 ± 15岁的成年人参与研究。三分之一（34 %）在基线时维生素d水平最佳，42 %维生素d不足（<75nmol/L）， 19 %维生素d不足（<50nmol/L）， 5 %严重缺乏（<25nmol/L）。大约一半（56% %）在研究前定期服用维生素d补充剂（1000-5000IU /天）。与其他维生素d组（50 %，平均2.5 ± 2）相比，严重缺乏维生素d组的呼吸系统疾病患病率略高（70 %，平均每年3例）。总体而言，维生素d水平越高，呼吸道疾病的发病率越低（第三组：r = -0.285;p = 0.009）。共有66名维生素d水平低于最佳水平的参与者（50 %）（n = 131）完成了维生素d3补充。3个月后，没有参与者维生素d缺乏，只有15 %仍然不足，而85 %达到最佳维生素d水平（平均97 ±4nmol/L）。结论最佳维生素d水平与呼吸道疾病的预防相关，在3个月内补充维生素d即可达到最佳水平。对公众健康的影响很大一部分澳大利亚人维生素d缺乏/不足。补充维生素d是缓解维生素d缺乏症和支持维生素d在通过先天和适应性免疫系统预防急性呼吸道感染中的作用的关键。

{"title":"Prevalence of Vitamin-D deficiency and respiratory tract infections in adults: A cross-sectional study","authors":"Karin Ried , Avni Sali","doi":"10.1016/j.aimed.2025.100587","DOIUrl":"10.1016/j.aimed.2025.100587","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the prevalence of Vitamin-D deficiency and respiratory illnesses in Australian adults.</div></div><div><h3>Methods</h3><div>In a cross-sectional sample of Australian adults, serum Vitamin-D levels and frequency of cold and flu symptoms were assessed. Those with sub-optimal Vitamin-D levels (<75nmol/L) were supplied with 4000–10,000IU Vitamin-D3 daily for 3-months. Data was analyzed with ANOVA and Pearson-correlation.</div></div><div><h3>Results</h3><div>A total of 199 adults aged 57 ± 15 years participated in the study. A third (34 %) had optimal Vitamin-D levels at baseline, 42 % were insufficient (<75nmol/L), 19 % deficient (<50nmol/L) and 5 % severely-deficient (<25nmol/L). About half (56 %) had regularly taken Vitamin-D supplements (1000–5000IU/day) prior to the study.</div><div>The prevalence of respiratory illnesses was slightly higher (70 %, mean=3-per-year) in the severely-deficient-group compared to other Vitamin-D-groups (50 %, mean 2.5 ± 2).</div><div>Overall, the frequency of respiratory illnesses tended to be lower with higher Vitamin-D levels (group 3: r = -0.285; p = 0.009).</div><div>A total of 66 participants (50 %) with sub-optimal Vitamin-D levels (n = 131) completed Vitamin-D3 supplementation. After 3-months, no participants were Vitamin-D deficient, only 15 % remained insufficient, while 85 % reached optimal Vitamin-D levels (mean 97 ± 4nmol/L).</div></div><div><h3>Conclusion</h3><div>Optimal Vitamin-D levels are correlated with the prevention of respiratory illnesses, and can be achieved with Vitamin-D supplementation within 3-months.</div></div><div><h3>Implications for public health</h3><div>A large proportion of Australians are Vitamin-D deficient/insufficient. Vitamin-D supplementation is key to alleviate Vitamin-D deficiency and support Vitamin-D’s role in the prevention of acute respiratory infections via the innate and adaptive immune system.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100587"},"PeriodicalIF":1.7,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbal remedies from Persian medicine for relieving fatigue: A systematic review 波斯医学缓解疲劳的草药疗法：系统回顾

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-16 DOI: 10.1016/j.aimed.2025.100585

Ata Amani , Bayazid Ghaderi , Mehdi Pasalar , Ali Kashkooe , Mohammad Mehdi Zarshenas , Reza Tabrizi , Thomas Rampp , Ghazaleh Heydarirad

Introduction

Fatigue is a common issue affecting individuals from diverse backgrounds, often leading to a decrease in overall health. Numerous foods, including medicinal plants, possess properties that help combat fatigue through two main mechanisms: antioxidant and anti-inflammatory effects. We aimed to explore the knowledge and potential of herbal medicines originated from Persian medicine (PM) in relieving fatigue.

Methods

This systematic review used a thorough search strategy, examining various historical Persian Medicine textbooks and electronic databases in both Persian and English. Herbal remedies that met the inclusion criteria were considered, particularly those exhibiting antioxidant and anti-inflammatory properties. Data from selected studies were extracted and thematically synthesized.

Results

A total of 49 herbal medicines were identified from Persian Medicine, showcasing varying temperaments. Among 44 articles meeting inclusion criteria, clinical trials demonstrated the effectiveness of several herbs, including Acacia arabica, Brassica rapa, Camellia sinensis, and Coffea arabica, in alleviating fatigue in humans. Additionally, Areca catechu and Phoenix dactylifera were effective in animal studies. The included articles assessed the methods and mechanisms of action for all herbal preparations, illuminating their anti-fatigue properties and the quality of supporting evidence.

Conclusions

Various herbs showed potential anti-fatigue properties in humans and animals, emphasizing the role of traditional modalities like PM. While further research is essential to validate and understand these effects, the identified herbs show potential for providing relief from fatigue.

疲劳是一个影响不同背景的人的普遍问题，经常导致整体健康状况下降。许多食物，包括药用植物，都具有通过两种主要机制来对抗疲劳的特性：抗氧化和抗炎作用。我们的目的是探索波斯医学草药在缓解疲劳方面的知识和潜力。方法本系统综述采用了全面的检索策略，检查了各种波斯医学历史教科书和波斯语和英语电子数据库。符合纳入标准的草药被考虑，特别是那些表现出抗氧化和抗炎特性的草药。从选定的研究中提取数据并按主题进行综合。结果从波斯医学中鉴定出49种中草药，表现出不同的气质。在44篇符合纳入标准的文章中，临床试验证明了几种草药的有效性，包括阿拉伯相思、油菜、茶花和阿拉比卡咖啡，可以缓解人类的疲劳。此外，槟榔和凤凰花在动物实验中也有效。纳入的文章评估了所有草药制剂的方法和作用机制，阐明了它们的抗疲劳性能和支持证据的质量。结论多种中药对人体和动物均有潜在的抗疲劳作用，强调了传统中药如PM的作用。虽然进一步的研究对验证和理解这些影响是必要的，但已确定的草药显示出缓解疲劳的潜力。

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引用次数: 0

The effect of Lapis Judaicus compared with hydrochlorothiazide on kidney stones 比较犹太青金石与氢氯噻嗪治疗肾结石的疗效

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-08 DOI: 10.1016/j.aimed.2025.100583

Elham Akbarzadeh , Mohammad Mehdi Hosseini , Zohreh Abolhassanzadeh , Ebrahim Fallahzadeh Abarghooei , Shahrokh Ezzatzadegan Jahromi , Seyed Hamed Jafari , Alireza Mohamadian , Amir Mohammad Jaladat

Introduction

More than one million referrals to the emergency department worldwide is related to kidney stones. Lapis Judaicus (LJ) as an ancient treatment of kidney stones has been described by Dioscorides, Galen, and some famaous Iranian scholars such as Ibn Sina, Razi, and Ahvazi and currently is used in the folk medicine market of Iran, Pakistan, Afghanistan, and India. Despite its popularity in some regions, few studies have evaluated its effect on renal stones. In this study, we investigated the effect of LJ in comparison with hydrochlorothiazide (HCTZ) on renal stone.

Methods

Seventy–seven adult patients with a stable and opaque kidney stones equal or greater than 5 mm, who received no treatment for their kidney stone in the past month were recruited and randomized into three groups: A) HCTZ (12.5 mg capsules two each morning, N = 25), B) LJ+HCTZ (1gr capsules two each morning +12.5 mg HCTZ N = 27), and C) LJ (1gr capsules two each morning, N = 25) for 2 months. After the intervention (the end of 2 months), checking serum and urinary parameters and kidney ultrasound were performed and compared with pre-intervention findings.

Results

A significant decrease was found in the size of renal stones in groups B and C. LJ alone or with hydrochlorothiazide did not cause any significant change in serum and urine parameters between before and after treatment (P > 0.05).

Conclusion

The stone sizes changed significantly in two groups that received LJ, compared with HCTZ, without any significant effect on liver enzymes or renal function.

导读：全世界有超过100万的急诊患者与肾结石有关。犹太教青金石（LJ）作为一种古老的治疗肾结石的药物被迪奥斯科里德、盖伦和一些著名的伊朗学者如伊本·西纳、拉齐、阿瓦齐描述，目前在伊朗、巴基斯坦、阿富汗和印度的民间医药市场上使用。尽管它在一些地区很受欢迎，但很少有研究评估它对肾结石的影响。在这项研究中，我们研究了LJ与氢氯噻嗪（HCTZ）对肾结石的影响。MethodsSeventy-seven成人患者一个稳定的和不透明的肾结石等于或大于5 mm,他们没有得到治疗肾结石在过去一个月被召集来,随机分为三组:a) HCTZ(12.5 毫克胶囊两个每天早晨,N = 25),B) LJ + HCTZ (1 gr胶囊每天早上两个+ 12.5 毫克HCTZ N = 27),和C) LJ (1 gr胶囊两个每天早晨,N = 25)2个月。干预后（2个月结束）行血清、尿参数及肾脏超声检查，并与干预前比较。结果B组和c组患者肾结石大小均明显减小，单独使用LJ或联合使用氢氯噻嗪治疗前后血清和尿液参数无显著变化（P >； 0.05）。结论LJ组与HCTZ组相比，结石大小有明显变化，对肝酶及肾功能无明显影响。

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引用次数: 0

Comparative effects of thyme and ginger on gastrointestinal symptom relief: A randomized controlled trial 百里香和生姜对胃肠道症状缓解的比较作用：一项随机对照试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-08 DOI: 10.1016/j.aimed.2025.100584

Mohammad Rostamkhani , Masoud Etedali , Azam Malek Hoseini , Hooman Mohammad talebi

Introduction

Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder with significant impacts on quality of life. Conventional treatments offer limited relief, prompting interest in herbal remedies. This study evaluates the efficacy of ginger (Zingiber officinale) and Shirazi thyme (Zataria multiflora) in managing IBS symptoms.

Methods

This double-blind, randomized clinical trial was conducted after obtaining the ethical approval. Sixty-six IBS patients, aged 20–50, were randomly assigned to three groups: ginger (1 g/day), Shirazi thyme (20 mg twice daily), or placebo (brown sugar) for four weeks. Participants completed the Gastrointestinal Symptom Rating Scale (GSRS) before and after treatment. Randomization minimized IBS subtype bias, and identical capsules ensured blinding. Data were analyzed using SPSS v22 to assess symptom changes.

Results

A total of 66 participants (42.4 % male, mean age 35.6 years) were enrolled and evenly allocated across the three groups. A one-way ANOVA revealed a significant group effect on post-intervention GSRS scores (F (2,63) = 85.2, p < 0.001). Post hoc analyses showed that the ginger group reported significantly lower GSRS scores compared with both the control (mean difference = −12.77, p < 0.001) and thyme groups (mean difference = −8.72, p < 0.001). Additionally, the thyme group had significantly lower scores than the control (mean difference = −4.05, p = 0.036). Only the ginger group showed a significant pre–post reduction in GSRS scores (p < 0.001).

Conclusion

Ginger significantly improved IBS symptoms, while thyme had a modest effect. Ginger appears promising as a complementary treatment, whereas thyme requires further investigation.

肠易激综合征（IBS）是一种常见的胃肠道疾病，对生活质量有显著影响。传统疗法的缓解效果有限，这促使人们对草药产生了兴趣。本研究评估生姜（Zingiber officinale）和百里香（Zataria multiflora）对IBS症状的治疗效果。方法获得伦理批准后进行双盲随机临床试验。66名年龄在20 - 50岁之间的IBS患者被随机分为三组：生姜（1 g/天），Shirazi百里香（20 mg /天两次）或安慰剂（红糖），持续四周。参与者在治疗前后完成胃肠症状评定量表（GSRS）。随机化最小化了IBS亚型偏倚，相同的胶囊确保了盲法。使用SPSS v22对数据进行分析，评估症状变化。结果共入组66例，男性42.4 %，平均年龄35.6岁。单因素方差分析显示干预后GSRS评分有显著的组效应（F(2,63) = 85.2,p <； 0.001）。事后分析显示，生姜组的GSRS评分显著低于对照组（平均差异= - 12.77,p <； 0.001）和百里香组（平均差异= - 8.72,p <； 0.001）。此外，百里香组得分显著低于对照组（平均差异= - 4.05,p = 0.036）。只有生姜组在GSRS评分中表现出显著的前后降低（p <； 0.001）。结论生姜能显著改善IBS症状，而百里香效果一般。生姜作为补充疗法似乎很有希望，而百里香则需要进一步研究。

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引用次数: 0

From microbes to medals: Integrative gut microbiome interventions for athletic excellence 从微生物到奖牌：综合肠道微生物组干预运动卓越

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-08 DOI: 10.1016/j.aimed.2025.100582

Emad M. Abdallah, Ahmed Emad Mohamed, Ozwan Moatasem Hassan, Sameh Yasser Amin, Waleed Hamid Aghbash

引用次数: 0

Effect of geriatric massage in elderly patients with type 2 diabetes: A randomized controlled trial 老年按摩对老年2型糖尿病患者的疗效：一项随机对照试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-08 DOI: 10.1016/j.aimed.2025.100581

Emine Apaydın , Sevilay Hintistan

Objective

This randomized controlled trial examined the effects of geriatric massage on diabetes-related symptoms and blood parameters in older adults with type 2 diabetes. The study included 59 participants (29 in the geriatric massage group and 30 in the control group).

Methods

Data were collected using the Older Adults Information Form, the Diabetes Symptoms Checklist, and the Blood Parameters Monitoring Form. Participants in the intervention group received 30-minute geriatric massage sessions twice weekly for 12 weeks. Statistical analyses included the Shapiro–Wilk test, Mann–Whitney U test, ANOVA, Friedman test, Wilcoxon test, Chi-square test, Fisher–Freeman–Halton test, Greenhouse–Geisser correction, Bonferroni adjustment, and paired and independent t-tests.

Results

Compared with the control group, participants receiving geriatric massage showed a significant reduction in diabetes symptoms (p < 0.001), an increase in HDL cholesterol levels, and decreases in other blood parameters (p < 0.05).

Discussion

Geriatric massage may help reduce diabetes symptoms and improve selected blood parameters in older adults with type 2 diabetes.

目的探讨老年按摩对老年2型糖尿病患者糖尿病相关症状和血液参数的影响。该研究包括59名参与者（老年按摩组29名，对照组30名）。方法采用《老年人信息表》、《糖尿病症状表》和《血液参数监测表》进行资料收集。干预组的参与者每周接受两次30分钟的老年按摩，持续12周。统计分析包括Shapiro-Wilk检验、Mann-Whitney U检验、方差分析、Friedman检验、Wilcoxon检验、卡方检验、Fisher-Freeman-Halton检验、Greenhouse-Geisser校正、Bonferroni调整、配对和独立t检验。结果与对照组相比，接受老年按摩的参与者糖尿病症状明显减轻（p <； 0.001），高密度脂蛋白胆固醇水平升高，其他血液参数降低（p <； 0.05）。老年按摩可以帮助老年2型糖尿病患者减轻糖尿病症状并改善选定的血液参数。

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