Propolis contains antioxidant compounds with antimicrobial and anti-inflammatory properties that can help control cancer progression and reduce chemotherapy side effects by influencing various biochemical pathways. Chemotherapy for ovarian cancer is associated with side effects such as nausea, vomiting, peripheral neuropathy, and anemia. It is anticipated honeybee propolis will effectively reduce these side effects
Study methods
This clinical trial involved 70 patients with epithelial ovarian cancer from Oct 2021 to Jun 2023 in Ghaem Hospital of Mashhad, Iran. The chemotherapy regimen included carboplatin and paclitaxel at standard dose, accompanied by a placebo control, while two capsules of Provex were administered daily throughout the treatment period. The incidence and severity of gastrointestinal side effects (nausea and vomiting) were evaluated using a Visual Analog Scale (VAS), along with liver function tests and blood factors before starting each course of chemotherapy and tumor marker CA-125 after three and six courses of chemotherapy.
Results
In the intervention group, the severity and frequency of nausea and vomiting significantly decreased compared to the control group (P < 0.001). No significant differences were observed in blood factors. CA-125 levels significantly decreased in both groups, indicating that propolis did not interfere with treatment.
Conclusion
Propolis reduces side effects in patients without interfering with chemotherapy. Therefore, it can be used as a supplement to enhance the quality of life for patients with epithelial ovarian cancer.
{"title":"The effect of propolis on the side effects of adjuvant chemotherapy in patients with epithelial ovarian cancer","authors":"Marjaneh Farazestanian , Nafiseh Saghafi , Elnaz Sadat Hosseini , Malihe Hasanzadeh Mofrad , Maryam Emadzadeh , Mansoureh Sadat Golmohammadi Tavalaei , Elham Dolat","doi":"10.1016/j.aimed.2026.100610","DOIUrl":"10.1016/j.aimed.2026.100610","url":null,"abstract":"<div><h3>Objective</h3><div>Propolis contains antioxidant compounds with antimicrobial and anti-inflammatory properties that can help control cancer progression and reduce chemotherapy side effects by influencing various biochemical pathways. Chemotherapy for ovarian cancer is associated with side effects such as nausea, vomiting, peripheral neuropathy, and anemia. It is anticipated honeybee propolis will effectively reduce these side effects</div></div><div><h3>Study methods</h3><div>This clinical trial involved 70 patients with epithelial ovarian cancer from Oct 2021 to Jun 2023 in Ghaem Hospital of Mashhad, Iran. The chemotherapy regimen included carboplatin and paclitaxel at standard dose, accompanied by a placebo control, while two capsules of Provex were administered daily throughout the treatment period. The incidence and severity of gastrointestinal side effects (nausea and vomiting) were evaluated using a Visual Analog Scale (VAS), along with liver function tests and blood factors before starting each course of chemotherapy and tumor marker CA-125 after three and six courses of chemotherapy.</div></div><div><h3>Results</h3><div>In the intervention group, the severity and frequency of nausea and vomiting significantly decreased compared to the control group (P < 0.001). No significant differences were observed in blood factors. CA-125 levels significantly decreased in both groups, indicating that propolis did not interfere with treatment.</div></div><div><h3>Conclusion</h3><div>Propolis reduces side effects in patients without interfering with chemotherapy. Therefore, it can be used as a supplement to enhance the quality of life for patients with epithelial ovarian cancer.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100610"},"PeriodicalIF":1.7,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-31DOI: 10.1016/j.aimed.2025.100607
Alastair C. Gray , Christine D. Luketic , Jess Coleman , Barbara Roberts
Complementary medicine (CM) appears to be thriving in New Zealand. Homeopathy is an important profession within the broader field of CM, yet there is little empirical evidence relating to homeopathy in New Zealand. In response, the aim of this study is to understand practitioner perceptions to the challenges faced in establishing and maintaining a practice, the broader systemic challenges faced by the homeopathic profession, as well as the supplementary forms of work and income undertaken by practitioners alongside their practice of homeopathy. An online survey was administered to homeopaths in New Zealand. The three biggest challenges identified were: ‘difficulty building a client base’ (11.7 %), a ‘lack of business skills and experience’ (10 %) and ‘confidence in building practice’ (8.6 %). The largest age grouping, 51–60-year-olds, found difficulties in ‘managing their confidence’, ‘applying business skills’, ‘experiencing feelings of isolation’ and identified that the ‘public of New Zealand did not understand homeopathy’. Many respondents (69 %) were engaged in homeopathy practice at least 6 h a week, with 25 % engaged in practice more than 20 h per week. Most respondents (64 %) see less than 5 clients per week. Many (66 %) of respondents reported that other work and income were required to supplement the income derived from homeopathy. Despite reporting satisfaction with their work, and readiness to practice homeopathy most homeopaths are in other employment. More than half of homeopaths in New Zealand (almost two thirds) have a second job and/or income supplementation, and this additional work can total on average 25 h per week. Practitioners perceive that they are learning on the job and require supplementary income at the same time. These two forces seem to be possibly incompatible and further examination of homeopaths’ perceptions appear warranted in order to more deeply understand the profession and practice of homeopathy in New Zealand.
{"title":"Tensions, challenges, risks and opportunities in the current and future delivery of homeopathy in New Zealand: A survey of practitioner perceptions","authors":"Alastair C. Gray , Christine D. Luketic , Jess Coleman , Barbara Roberts","doi":"10.1016/j.aimed.2025.100607","DOIUrl":"10.1016/j.aimed.2025.100607","url":null,"abstract":"<div><div>Complementary medicine (CM) appears to be thriving in New Zealand. Homeopathy is an important profession within the broader field of CM, yet there is little empirical evidence relating to homeopathy in New Zealand. In response, the aim of this study is to understand practitioner perceptions to the challenges faced in establishing and maintaining a practice, the broader systemic challenges faced by the homeopathic profession, as well as the supplementary forms of work and income undertaken by practitioners alongside their practice of homeopathy. An online survey was administered to homeopaths in New Zealand. The three biggest challenges identified were: ‘difficulty building a client base’ (11.7 %), a ‘lack of business skills and experience’ (10 %) and ‘confidence in building practice’ (8.6 %). The largest age grouping, 51–60-year-olds, found difficulties in ‘managing their confidence’, ‘applying business skills’, ‘experiencing feelings of isolation’ and identified that the ‘public of New Zealand did not understand homeopathy’. Many respondents (69 %) were engaged in homeopathy practice at least 6 h a week, with 25 % engaged in practice more than 20 h per week. Most respondents (64 %) see less than 5 clients per week. Many (66 %) of respondents reported that other work and income were required to supplement the income derived from homeopathy. Despite reporting satisfaction with their work, and readiness to practice homeopathy most homeopaths are in other employment. More than half of homeopaths in New Zealand (almost two thirds) have a second job and/or income supplementation, and this additional work can total on average 25 h per week. Practitioners perceive that they are learning on the job and require supplementary income at the same time. These two forces seem to be possibly incompatible and further examination of homeopaths’ perceptions appear warranted in order to more deeply understand the profession and practice of homeopathy in New Zealand.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100607"},"PeriodicalIF":1.7,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23DOI: 10.1016/j.aimed.2025.100605
Andressa Bressan Pedroso , Aline Josiane Waclawovsky , Eduarda Bitencourt dos Santos , Felipe Barreto Schuch , Gabriele Ferreira da Silva da Costa , Diego Chemello , Patrícia Chagas
Background and purpose
non-pharmacological therapies have been used as part of the treatment of insomnia. Laying on of Hands (LH) is an Integrative and Complementary Health Practice that involves the transfer of vital energy through touch and encompasses techniques such as Reiki and Therapeutic Touch (TT). The effects of LH on anxiety, depression, and stress have been studied through systematic reviews; however, to the best of our knowledge, the effect on sleep quality has not been systematically summarized. This study aimed to evaluate the effect of LH on the sleep quality of adults and elderly.
Methods
This is a systematic review of randomized clinical trials, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Clinical trials with adult and elderly population evaluating the effects of LH on sleep quality and related domains were included. The results of individual studies were analyzed qualitatively and the risk of bias was assessed using Rob2 tool.
Results
18,585 articles were found, and 9 were eligible for systematic review. The studies used different LH techniques, and were conducted in diverse populations. The results are mixed, with most studies suggest favorable effects of LH on sleep quality. However, these findings are based on studies with high or moderate risk of bias.
Conclusion
most studies found significant effects of LH on sleep quality; however, the lack of possibility of running a meta-analysis and the high risk of bias of the included studies requires caution when interpreting the findings of this study.
{"title":"Effect of the laying on of hands techniques on sleep quality: A systematic review","authors":"Andressa Bressan Pedroso , Aline Josiane Waclawovsky , Eduarda Bitencourt dos Santos , Felipe Barreto Schuch , Gabriele Ferreira da Silva da Costa , Diego Chemello , Patrícia Chagas","doi":"10.1016/j.aimed.2025.100605","DOIUrl":"10.1016/j.aimed.2025.100605","url":null,"abstract":"<div><h3>Background and purpose</h3><div>non-pharmacological therapies have been used as part of the treatment of insomnia. Laying on of Hands (LH) is an Integrative and Complementary Health Practice that involves the transfer of vital energy through touch and encompasses techniques such as Reiki and Therapeutic Touch (TT). The effects of LH on anxiety, depression, and stress have been studied through systematic reviews; however, to the best of our knowledge, the effect on sleep quality has not been systematically summarized. This study aimed to evaluate the effect of LH on the sleep quality of adults and elderly.</div></div><div><h3>Methods</h3><div>This is a systematic review of randomized clinical trials, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Clinical trials with adult and elderly population evaluating the effects of LH on sleep quality and related domains were included. The results of individual studies were analyzed qualitatively and the risk of bias was assessed using Rob2 tool.</div></div><div><h3>Results</h3><div>18,585 articles were found, and 9 were eligible for systematic review. The studies used different LH techniques, and were conducted in diverse populations. The results are mixed, with most studies suggest favorable effects of LH on sleep quality. However, these findings are based on studies with high or moderate risk of bias.</div></div><div><h3>Conclusion</h3><div>most studies found significant effects of LH on sleep quality; however, the lack of possibility of running a meta-analysis and the high risk of bias of the included studies requires caution when interpreting the findings of this study.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100605"},"PeriodicalIF":1.7,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iron nanoparticles (FeNPs) synthesized using the homeopathic medicine Thuja occidentalis mother tincture represent a promising candidate in nanomedicine due to their broad therapeutic potential. This study focuses on the characterization and biological evaluation of these nanoparticles synthesized through a green route.
Methods
Iron nanoparticles (FeNPs) were prepared using a green synthesis approach with Thuja occidentalis mother tincture as the reducing and stabilizing agent. The nanoparticles were characterized by Ultraviolet–Visible (UV–Vis) spectroscopy, Dynamic Light Scattering (DLS) analysis, Fourier Transform Infrared (FT–IR) spectroscopy, Scanning Electron Microscopy with Energy Dispersive X–ray (SEM–EDX) analysis, X–ray Diffraction (XRD), and Thermogravimetric Analysis (TGA).
Results
The anticancer activity of Thuja occidentalis-functionalized iron nanoparticles (TIONPs) was evaluated against AGS gastric cancer cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, revealing a dose-dependent cytotoxic effect. Antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, while anti-inflammatory potential was assessed via the albumin denaturation assay. Both tests demonstrated significant efficacy of the nanoparticles.
Conclusion
The findings indicate that Thuja occidentalis-functionalized iron nanoparticles (TIONPs) effectively target cancer cells, scavenge free radicals, and inhibit protein denaturation. The synthesis of iron nanoparticles (FeNPs) using Thuja occidentalis mother tincture is a sustainable and eco-friendly strategy, providing an avenue for developing safe nanomaterials with diverse biomedical applications.
{"title":"Bioinspired organometallic synthesis of iron nanoparticles using Thuja occidentalis: Anticancer, antioxidant and anti-inflammatory properties","authors":"Chandana Yesudas , Uma Maheshwari , Krishnan Raguvaran , Murni Handayani , Rajeshwari-Srinivasan Kaarmukhilnilavan , Illakkiam Devaraj , Murugesan Mohana Keerthi , Sri Sudewi , Akhtar Rasool","doi":"10.1016/j.aimed.2025.100608","DOIUrl":"10.1016/j.aimed.2025.100608","url":null,"abstract":"<div><h3>Background</h3><div>Iron nanoparticles (FeNPs) synthesized using the homeopathic medicine <em>Thuja occidentalis</em> mother tincture represent a promising candidate in nanomedicine due to their broad therapeutic potential. This study focuses on the characterization and biological evaluation of these nanoparticles synthesized through a green route.</div></div><div><h3>Methods</h3><div>Iron nanoparticles (FeNPs) were prepared using a green synthesis approach with Thuja occidentalis mother tincture as the reducing and stabilizing agent. The nanoparticles were characterized by Ultraviolet–Visible (UV–Vis) spectroscopy, Dynamic Light Scattering (DLS) analysis, Fourier Transform Infrared (FT–IR) spectroscopy, Scanning Electron Microscopy with Energy Dispersive X–ray (SEM–EDX) analysis, X–ray Diffraction (XRD), and Thermogravimetric Analysis (TGA).</div></div><div><h3>Results</h3><div>The anticancer activity of <em>Thuja occidentalis</em>-functionalized iron nanoparticles (TIONPs) was evaluated against AGS gastric cancer cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, revealing a dose-dependent cytotoxic effect. Antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, while anti-inflammatory potential was assessed via the albumin denaturation assay. Both tests demonstrated significant efficacy of the nanoparticles.</div></div><div><h3>Conclusion</h3><div>The findings indicate that <em>Thuja occidentalis</em>-functionalized iron nanoparticles (TIONPs) effectively target cancer cells, scavenge free radicals, and inhibit protein denaturation. The synthesis of iron nanoparticles (FeNPs) using Thuja occidentalis mother tincture is a sustainable and eco-friendly strategy, providing an avenue for developing safe nanomaterials with diverse biomedical applications.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100608"},"PeriodicalIF":1.7,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.aimed.2025.100604
Y. Rosy Ayda , Abinaya Suresh , M. Alkousar Taz , MaheshKumar Kuppysamy
Intervertebral disc bulge (IVDB) is a prevalent spinal condition that significantly affects quality of life, yet current diagnostic methods can be expensive and not always easily accessible. This study explores the potential of pupil flattening as an iridological marker for IVDB. A case-control study was conducted with 60 IVDB patients and 60 healthy controls. High-resolution iris images were analyzed for pupil flattening, revealing a markedly higher prevalence in IVDB patients (88.3 % in the right iris, 81.7 % in the left iris) compared to controls (15 % in the right iris, 10 % in the left iris). ROC analysis demonstrated strong diagnostic accuracy, with AUC values of 0.79 for males (95 % CI: 0.60–0.98) and 0.88 (95 % CI: 0.78–0.99) for females. Sensitivity and specificity were particularly high in females, at 80 % and 97.62 %, respectively. These findings indicate that pupil flattening could serve as a non-invasive, cost-effective diagnostic tool for IVDB, offering a potential complement to existing diagnostic approaches.
{"title":"Pupil flattening as a diagnostic marker for intervertebral disc bulge: An iridology-based approach","authors":"Y. Rosy Ayda , Abinaya Suresh , M. Alkousar Taz , MaheshKumar Kuppysamy","doi":"10.1016/j.aimed.2025.100604","DOIUrl":"10.1016/j.aimed.2025.100604","url":null,"abstract":"<div><div>Intervertebral disc bulge (IVDB) is a prevalent spinal condition that significantly affects quality of life, yet current diagnostic methods can be expensive and not always easily accessible. This study explores the potential of pupil flattening as an iridological marker for IVDB. A case-control study was conducted with 60 IVDB patients and 60 healthy controls. High-resolution iris images were analyzed for pupil flattening, revealing a markedly higher prevalence in IVDB patients (88.3 % in the right iris, 81.7 % in the left iris) compared to controls (15 % in the right iris, 10 % in the left iris). ROC analysis demonstrated strong diagnostic accuracy, with AUC values of 0.79 for males (95 % CI: 0.60–0.98) and 0.88 (95 % CI: 0.78–0.99) for females. Sensitivity and specificity were particularly high in females, at 80 % and 97.62 %, respectively. These findings indicate that pupil flattening could serve as a non-invasive, cost-effective diagnostic tool for IVDB, offering a potential complement to existing diagnostic approaches.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100604"},"PeriodicalIF":1.7,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145836871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.aimed.2025.100606
Dibyendu Mandal , Soumyadeep Maity , Sudeshna Sardar , Abhijit Rana , Srijana Panda , Soma Pramanick , Subhranil Saha
Background
Needle punctures during hematology practicals can induce discomfort, anxiety, and diminished cooperation. Homeopathic literature indicates Hypericum perforatum for puncture wounds and neuropathic pain. This trial aimed to evaluate the efficacy of Hypericum perforatum 200CH in preventing and treating fingertip puncture site pain and tenderness compared with placebo.
Methods
An exploratory, double-blind, randomized (2:1), placebo-controlled study was conducted with 90 undergraduate students during hematology practical classes. Participants were randomly allocated to the Hypericum perforatum 200CH group (n = 60) or the placebo group (n = 30). Three doses were administered: the night before, thirty minutes earlier, and immediately after the puncture. Standardized fingertip punctures were performed once using sterile lancets and pricking guns, with the instrument calibrated to 0.5 to ensure procedural uniformity. The primary outcome was the time until total relief of pain and tenderness. The secondary outcome measure was the intensity of pain and tenderness, evaluated using a pain visual analog scale (VAS; 0–100 mm), measured until the 4th day.
Results
Kaplan-Meier analysis indicated a significantly shorter median time to achieve complete pain resolution in the Hypericum perforatum 200CH group (10 h versus 14 h; log-rank test, p < 0.001). Tenderness scores exhibited no significant differences between the groups (p = 0.475). The group difference in the pain VAS score was statistically significant, favoring the Hypericum perforatum group compared to placebo (p < 0.001). No adverse events were recorded.
Conclusion
A significantly faster resolution of pain was achieved in the Hypericum perforatum 200CH group compared with placebo; however, no impact on tenderness was noted.
背景：血液学实习中针刺可引起不适、焦虑和减少合作。顺势疗法文献表明贯叶连翘用于穿刺伤口和神经性疼痛。本试验旨在比较贯叶连翘200CH与安慰剂对指尖穿刺部位疼痛和压痛的预防和治疗效果。方法采用探索性、双盲、随机（2:1）、安慰剂对照的方法，对90名血液学实训本科生进行研究。参与者被随机分配到贯叶连体200CH组（n = 60）或安慰剂组（n = 30）。注射三次：前一晚、前三十分钟和穿刺后。标准化指尖穿刺一次，使用无菌枪和穿刺枪，仪器校准至0.5，确保操作均匀。主要观察指标是疼痛和压痛完全缓解的时间。次要结果测量是疼痛和压痛的强度，使用疼痛视觉模拟量表（VAS; 0-100 mm）评估，测量至第4天。结果kaplan - meier分析显示，贯叶连片200CH组实现完全疼痛缓解的中位时间显著缩短（10 h vs 14 h； log-rank检验，p <； 0.001）。压痛评分组间差异无统计学意义（p = 0.475）。疼痛VAS评分组间差异有统计学意义，贯叶连翘组优于安慰剂组（p <； 0.001）。无不良事件记录。结论贯叶连翘200CH组疼痛缓解明显快于安慰剂组；然而，没有注意到对压痛的影响。
{"title":"An exploratory, randomized, placebo-controlled, double-blind trial of Hypericum perforatum 200CH in preventing and treating fingertip puncture site pain and tenderness","authors":"Dibyendu Mandal , Soumyadeep Maity , Sudeshna Sardar , Abhijit Rana , Srijana Panda , Soma Pramanick , Subhranil Saha","doi":"10.1016/j.aimed.2025.100606","DOIUrl":"10.1016/j.aimed.2025.100606","url":null,"abstract":"<div><h3>Background</h3><div>Needle punctures during hematology practicals can induce discomfort, anxiety, and diminished cooperation. Homeopathic literature indicates <em>Hypericum perforatum</em> for puncture wounds and neuropathic pain. This trial aimed to evaluate the efficacy of <em>Hypericum perforatum</em> 200CH in preventing and treating fingertip puncture site pain and tenderness compared with placebo.</div></div><div><h3>Methods</h3><div>An exploratory, double-blind, randomized (2:1), placebo-controlled study was conducted with 90 undergraduate students during hematology practical classes. Participants were randomly allocated to the <em>Hypericum perforatum</em> 200CH group (<em>n = 60</em>) or the placebo group (<em>n</em> = 30). Three doses were administered: the night before, thirty minutes earlier, and immediately after the puncture. Standardized fingertip punctures were performed once using sterile lancets and pricking guns, with the instrument calibrated to 0.5 to ensure procedural uniformity. The primary outcome was the time until total relief of pain and tenderness. The secondary outcome measure was the intensity of pain and tenderness, evaluated using a pain visual analog scale (VAS; 0–100 mm), measured until the 4th day.</div></div><div><h3>Results</h3><div>Kaplan-Meier analysis indicated a significantly shorter median time to achieve complete pain resolution in the <em>Hypericum perforatum</em> 200CH group (10 h versus 14 h; log-rank test, <em>p</em> < 0.001). Tenderness scores exhibited no significant differences between the groups (<em>p</em> = 0.475). The group difference in the pain VAS score was statistically significant, favoring the <em>Hypericum perforatum</em> group compared to placebo (<em>p</em> < 0.001). No adverse events were recorded.</div></div><div><h3>Conclusion</h3><div>A significantly faster resolution of pain was achieved in the <em>Hypericum perforatum</em> 200CH group compared with placebo; however, no impact on tenderness was noted.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100606"},"PeriodicalIF":1.7,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadi Pariksha (Pulse Diagnosis) is a well-known diagnostic method in Ayurveda where physicians assess a patient's pathological and physiological status through tridosha analysis. The diagnostic procedure is subjective, and there is a need to understand it better.
Objective
This study quantifies the perceptions and challenges of Ayurvedic physicians in performing Nadi Pariksha and its implications for treating diseases.
Materials and methods
The sample for this study comprised 91 Ayurvedic physicians from various regions of India. They were interviewed and asked to complete a series of questionnaires that focused on their difficulties in performing Nadi Pariksha. Hypothesis formulation, validation, and testing were carried out using statistical methods.
Results
A two-sample Mann-Whitney statistical method was used to infer physicians’ perceptions of various hypotheses. The judgements of Ayurvedic physicians with varying experience levels disagreed with the hypothesis of longer diagnostic time (p-value=0.003). However, they reached a consensus on the hypotheses relating to quantification (p-value = 0.609), learning curve (p-value = 0.355), and subjectivity (p-value=0.161).
Conclusions
The study suggests a need for objective characterization of the arterial pulse in concluding a diagnosis. Standardizing diagnostic approaches may enhance accuracy. Technology-based research would make Ayurveda more evidence-based. Moreover, there is a need for a diagnostic tool or assistive device for less experienced physicians to accelerate their learning and gain confidence in concluding a diagnosis more accurately and quickly. This can reduce the likelihood of incorrect diagnoses and unnecessary treatments, significantly enhancing patient outcomes and the overall efficiency of Ayurveda healthcare.
{"title":"Perceptions of Ayurvedic physicians on Nadi Pariksha in traditional Indian medicine – A pan India study and quantitative analysis","authors":"Saurav Kumar , Apakrita Tayade , Prabhat Kumar , Vinayak Tayade , Sanjay Chhajed , Ravi Bhallamudi","doi":"10.1016/j.aimed.2025.100603","DOIUrl":"10.1016/j.aimed.2025.100603","url":null,"abstract":"<div><h3>Background</h3><div>Nadi Pariksha (Pulse Diagnosis) is a well-known diagnostic method in Ayurveda where physicians assess a patient's pathological and physiological status through <em>tridosha</em> analysis. The diagnostic procedure is subjective, and there is a need to understand it better.</div></div><div><h3>Objective</h3><div>This study quantifies the perceptions and challenges of Ayurvedic physicians in performing Nadi Pariksha and its implications for treating diseases.</div></div><div><h3>Materials and methods</h3><div>The sample for this study comprised 91 Ayurvedic physicians from various regions of India. They were interviewed and asked to complete a series of questionnaires that focused on their difficulties in performing Nadi Pariksha. Hypothesis formulation, validation, and testing were carried out using statistical methods.</div></div><div><h3>Results</h3><div>A two-sample Mann-Whitney statistical method was used to infer physicians’ perceptions of various hypotheses. The judgements of Ayurvedic physicians with varying experience levels disagreed with the hypothesis of longer diagnostic time (p-value=0.003). However, they reached a consensus on the hypotheses relating to quantification (p-value = 0.609), learning curve (p-value = 0.355), and subjectivity (p-value=0.161).</div></div><div><h3>Conclusions</h3><div>The study suggests a need for objective characterization of the arterial pulse in concluding a diagnosis. Standardizing diagnostic approaches may enhance accuracy. Technology-based research would make Ayurveda more evidence-based. Moreover, there is a need for a diagnostic tool or assistive device for less experienced physicians to accelerate their learning and gain confidence in concluding a diagnosis more accurately and quickly. This can reduce the likelihood of incorrect diagnoses and unnecessary treatments, significantly enhancing patient outcomes and the overall efficiency of Ayurveda healthcare.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100603"},"PeriodicalIF":1.7,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.aimed.2025.100602
Laura Fetterplace , Nicole Peel , Janette Young
Background
The demand for Animal Assisted Activities s (AAA) is increasing, as is the research on these interactions. Extensive human-centric evidence on the health benefits of AAA to human clients exists. However, research into both handler and dog experiences has been limited representation, it is essential to include these perspectives to add value to this field, ensuring ethical and evidence-based practices in working partnerships.
Aims
The purpose of this pilot study was to comprehensively explore the perspectives and experiences of dogs and handlers engaged in AAA utilizing a multispecies approach.
Methods
This study was informed by a multispecies ethnographic approach. In this two stage dual source research, data were collected via seven semi-structured interviews with AAA handlers and three observations of their dogs during AAA sessions. Interview data was analysed thematically, and observations are presented as narrative descriptions.
Findings
Five key themes emerged: dogs as a working resource; dogs shaping therapy; animal welfare prioritized; putting others first (human motivations); putting others first (influence of the animal) with a hierarchy presented of dogs being the primary consideration, followed by clients, then the handler. Observations of the dogs indicated a more human-centric hierarchy in AAA sessions with canine team members indications of caution not always identified or responded to. Other observations indicated simple techniques that can increase the agency of canine team members in AAA.
Conclusions
Even in the presence of genuinely held concerns for animal consent and welfare, handlers’ human-centric altruistic motivations may impact their dogs’ agency and control in AAA. Animals involved in AAA should be given more choice in interactions to improve their wellbeing. Human and animal beings are inseparable in AAA and other animal-inclusive, human focused activities, future research needs to increasingly seek to include the animal perspective when investigating this field.
{"title":"The experiences of providing animal-assisted activities s: A multispecies ethnographic study","authors":"Laura Fetterplace , Nicole Peel , Janette Young","doi":"10.1016/j.aimed.2025.100602","DOIUrl":"10.1016/j.aimed.2025.100602","url":null,"abstract":"<div><h3>Background</h3><div>The demand for Animal Assisted Activities s (AAA) is increasing, as is the research on these interactions. Extensive human-centric evidence on the health benefits of AAA to human clients exists. However, research into both handler and dog experiences has been limited representation, it is essential to include these perspectives to add value to this field, ensuring ethical and evidence-based practices in working partnerships.</div></div><div><h3>Aims</h3><div>The purpose of this pilot study was to comprehensively explore the perspectives and experiences of dogs and handlers engaged in AAA utilizing a multispecies approach.</div></div><div><h3>Methods</h3><div>This study was informed by a multispecies ethnographic approach. In this two stage dual source research, data were collected via seven semi-structured interviews with AAA handlers and three observations of their dogs during AAA sessions. Interview data was analysed thematically, and observations are presented as narrative descriptions.</div></div><div><h3>Findings</h3><div>Five key themes emerged: dogs as a working resource; dogs shaping therapy; animal welfare prioritized; putting others first (human motivations); putting others first (influence of the animal) with a hierarchy presented of dogs being the primary consideration, followed by clients, then the handler. Observations of the dogs indicated a more human-centric hierarchy in AAA sessions with canine team members indications of caution not always identified or responded to. Other observations indicated simple techniques that can increase the agency of canine team members in AAA.</div></div><div><h3>Conclusions</h3><div>Even in the presence of genuinely held concerns for animal consent and welfare, handlers’ human-centric altruistic motivations may impact their dogs’ agency and control in AAA. Animals involved in AAA should be given more choice in interactions to improve their wellbeing. Human and animal beings are inseparable in AAA and other animal-inclusive, human focused activities, future research needs to increasingly seek to include the animal perspective when investigating this field.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100602"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aims to implement and evaluate the Stress Management and Resiliency Training (SMART) program, considering the significant negative effects of stress on individual health, particularly among mothers.
Materials and methods
This quasi-experimental study followed a pre/post-test design and was conducted in 2023 with 50 mothers receiving services from healthcare centers in Yazd, Iran. The SMART program was delivered over eight weekly sessions, each lasting 60–90 min. Data collection utilized Cohen's Perceived Stress Scale and the Connor-Davidson Resilience Questionnaire before and after the training. Upon program completion, participants also completed an Acceptability and Feasibility Scale questionnaire. Data were analyzed using t-tests and ANOVA in SPSS software.
Results
The average age of participants was 39.68 ± 9.10 years. Most were housewives (88 %) and held bachelor's degrees (36 %). After the intervention, resilience scores significantly increased (mean difference =-3.64, SD = 5.10, Cohen’s d = 0.71, p = 0.0001), while perceived stress scores significantly decreased (mean difference = 4.82, SD = 5.56, Cohen’s d = 0.87, p = 0.0001). These findings suggest that the SMART program was effective in reducing stress and enhancing resilience among mothers. Moreover, demographic variables such as age, education level, and number of children were found to influence the effectiveness of the intervention. Results from the Acceptability and Feasibility Scale further indicated that the program was well-received and feasible for implementation in this population.
Conclusion
The findings of this study demonstrate that the SMART program is an effective approach for enhancing resilience and reducing stress among mothers. However, the small, homogeneous sample and absence of a control group limit the generalizability and causal interpretation of the results. Further studies with diverse samples and long-term follow-up are recommended.
{"title":"Stress Management and Resiliency Training (SMART) program among mothers receiving services from health care centers: A pilot study","authors":"Fahimeh Dehghani , Seyed Saeed Mazloomy Mahmoudabad , Reza Aghazadeh , Nahid Ardian , Deepak Palival","doi":"10.1016/j.aimed.2025.100601","DOIUrl":"10.1016/j.aimed.2025.100601","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to implement and evaluate the Stress Management and Resiliency Training (SMART) program, considering the significant negative effects of stress on individual health, particularly among mothers.</div></div><div><h3>Materials and methods</h3><div>This quasi-experimental study followed a pre/post-test design and was conducted in 2023 with 50 mothers receiving services from healthcare centers in Yazd, Iran. The SMART program was delivered over eight weekly sessions, each lasting 60–90 min. Data collection utilized Cohen's Perceived Stress Scale and the Connor-Davidson Resilience Questionnaire before and after the training. Upon program completion, participants also completed an Acceptability and Feasibility Scale questionnaire. Data were analyzed using t-tests and ANOVA in SPSS software.</div></div><div><h3>Results</h3><div>The average age of participants was 39.68 ± 9.10 years. Most were housewives (88 %) and held bachelor's degrees (36 %). After the intervention, resilience scores significantly increased (mean difference =-3.64, SD = 5.10, Cohen’s d = 0.71, p = 0.0001), while perceived stress scores significantly decreased (mean difference = 4.82, SD = 5.56, Cohen’s d = 0.87, p = 0.0001). These findings suggest that the SMART program was effective in reducing stress and enhancing resilience among mothers. Moreover, demographic variables such as age, education level, and number of children were found to influence the effectiveness of the intervention. Results from the Acceptability and Feasibility Scale further indicated that the program was well-received and feasible for implementation in this population.</div></div><div><h3>Conclusion</h3><div>The findings of this study demonstrate that the SMART program is an effective approach for enhancing resilience and reducing stress among mothers. However, the small, homogeneous sample and absence of a control group limit the generalizability and causal interpretation of the results. Further studies with diverse samples and long-term follow-up are recommended.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100601"},"PeriodicalIF":1.7,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.aimed.2025.100592
Anaheed Shirazi , Niloofar Radgoudarzi , Hyun-Chung Kim , Marta Patterson , Shahrzad Bazargan-Hejazi , Matthew S. Herbert , Desiree Shapiro , Flora Wong , Lisa T. Eyler
Objectives
The role of self-compassion (SC) in improving wellness in healthcare communities and its association with emotional intelligence (EI) has been highlighted by previous studies. Despite the prominence of emotions in psychiatric encounters, research on SC training on EI and wellness among psychiatry residents is limited. This preliminary, hypothesis-generating study aimed to explore the feasibility, acceptability, and trends for potential effects of a tailored Mindful Self-Compassion (MSC) program for psychiatry residents, to guide future larger-scale trials.
Method
A waitlist-control study assessing the feasibility, acceptability, and effects of Mindful SC training tailored for psychiatry residents. Preliminary effects were assessed by Santa Clara Brief Compassion Scale, Neff’s Self-Compassion Scale–Short-form, Trait Emotional Intelligence Questionnaire–Short-form, Mini Z Burnout Survey, Very Brief Quality of Life Enjoyment and Satisfaction Questionnaire, Perceived Stress Scale, Inclusion of Other in the Self Scale, and Freiburg Mindfulness Inventory. Non-parametric tests compared changes across cohorts and pre-post intervention. Qualitative data, interest, and attendance rates were explored to assess program acceptability and feasibility.
Results
Of 18 participants, 12 completed the study. It was likely (mean = 4.00 out of 5, 5 being highly likely) for participants to incorporate empathy and compassion into their daily lives. Only 1 participant attended all 6 sessions. Conflicts with work schedules were reported as the main barriers. The intervention cohort showed a higher increase in EI (P = 0.003) and SC (P = 0.010) from pre- to post-intervention vs the waitlist group.
Conclusions
Preliminary results suggest that mindful-self compassion training for psychiatry residents may improve their EI and SC and is acceptable and highly recommended by those who participated in the intervention. To improve attendance rates, allocating protected time within the curricula should be considered.
{"title":"A preliminary study of acceptability, feasibility and effects of a mindful self-compassion intervention on emotional intelligence and wellbeing among psychiatry residents","authors":"Anaheed Shirazi , Niloofar Radgoudarzi , Hyun-Chung Kim , Marta Patterson , Shahrzad Bazargan-Hejazi , Matthew S. Herbert , Desiree Shapiro , Flora Wong , Lisa T. Eyler","doi":"10.1016/j.aimed.2025.100592","DOIUrl":"10.1016/j.aimed.2025.100592","url":null,"abstract":"<div><h3>Objectives</h3><div>The role of self-compassion (SC) in improving wellness in healthcare communities and its association with emotional intelligence (EI) has been highlighted by previous studies. Despite the prominence of emotions in psychiatric encounters, research on SC training on EI and wellness among psychiatry residents is limited. This preliminary, hypothesis-generating study aimed to explore the feasibility, acceptability, and trends for potential effects of a tailored Mindful Self-Compassion (MSC) program for psychiatry residents, to guide future larger-scale trials.</div></div><div><h3>Method</h3><div>A waitlist-control study assessing the feasibility, acceptability, and effects of Mindful SC training tailored for psychiatry residents. Preliminary effects were assessed by Santa Clara Brief Compassion Scale, Neff’s Self-Compassion Scale–Short-form, Trait Emotional Intelligence Questionnaire–Short-form, Mini Z Burnout Survey, Very Brief Quality of Life Enjoyment and Satisfaction Questionnaire, Perceived Stress Scale, Inclusion of Other in the Self Scale, and Freiburg Mindfulness Inventory. Non-parametric tests compared changes across cohorts and pre-post intervention. Qualitative data, interest, and attendance rates were explored to assess program acceptability and feasibility.</div></div><div><h3>Results</h3><div>Of 18 participants, 12 completed the study. It was likely (mean = 4.00 out of 5, 5 being highly likely) for participants to incorporate empathy and compassion into their daily lives. Only 1 participant attended all 6 sessions. Conflicts with work schedules were reported as the main barriers. The intervention cohort showed a higher increase in EI (P = 0.003) and SC (P = 0.010) from pre- to post-intervention vs the waitlist group.</div></div><div><h3>Conclusions</h3><div>Preliminary results suggest that mindful-self compassion training for psychiatry residents may improve their EI and SC and is acceptable and highly recommended by those who participated in the intervention. To improve attendance rates, allocating protected time within the curricula should be considered.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 1","pages":"Article 100592"},"PeriodicalIF":1.7,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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