Advances in integrative medicine最新文献_第3页

Herbal remedies from Persian medicine for relieving fatigue: A systematic review 波斯医学缓解疲劳的草药疗法：系统回顾

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-16 DOI: 10.1016/j.aimed.2025.100585

Ata Amani , Bayazid Ghaderi , Mehdi Pasalar , Ali Kashkooe , Mohammad Mehdi Zarshenas , Reza Tabrizi , Thomas Rampp , Ghazaleh Heydarirad

Introduction

Fatigue is a common issue affecting individuals from diverse backgrounds, often leading to a decrease in overall health. Numerous foods, including medicinal plants, possess properties that help combat fatigue through two main mechanisms: antioxidant and anti-inflammatory effects. We aimed to explore the knowledge and potential of herbal medicines originated from Persian medicine (PM) in relieving fatigue.

Methods

This systematic review used a thorough search strategy, examining various historical Persian Medicine textbooks and electronic databases in both Persian and English. Herbal remedies that met the inclusion criteria were considered, particularly those exhibiting antioxidant and anti-inflammatory properties. Data from selected studies were extracted and thematically synthesized.

Results

A total of 49 herbal medicines were identified from Persian Medicine, showcasing varying temperaments. Among 44 articles meeting inclusion criteria, clinical trials demonstrated the effectiveness of several herbs, including Acacia arabica, Brassica rapa, Camellia sinensis, and Coffea arabica, in alleviating fatigue in humans. Additionally, Areca catechu and Phoenix dactylifera were effective in animal studies. The included articles assessed the methods and mechanisms of action for all herbal preparations, illuminating their anti-fatigue properties and the quality of supporting evidence.

Conclusions

Various herbs showed potential anti-fatigue properties in humans and animals, emphasizing the role of traditional modalities like PM. While further research is essential to validate and understand these effects, the identified herbs show potential for providing relief from fatigue.

疲劳是一个影响不同背景的人的普遍问题，经常导致整体健康状况下降。许多食物，包括药用植物，都具有通过两种主要机制来对抗疲劳的特性：抗氧化和抗炎作用。我们的目的是探索波斯医学草药在缓解疲劳方面的知识和潜力。方法本系统综述采用了全面的检索策略，检查了各种波斯医学历史教科书和波斯语和英语电子数据库。符合纳入标准的草药被考虑，特别是那些表现出抗氧化和抗炎特性的草药。从选定的研究中提取数据并按主题进行综合。结果从波斯医学中鉴定出49种中草药，表现出不同的气质。在44篇符合纳入标准的文章中，临床试验证明了几种草药的有效性，包括阿拉伯相思、油菜、茶花和阿拉比卡咖啡，可以缓解人类的疲劳。此外，槟榔和凤凰花在动物实验中也有效。纳入的文章评估了所有草药制剂的方法和作用机制，阐明了它们的抗疲劳性能和支持证据的质量。结论多种中药对人体和动物均有潜在的抗疲劳作用，强调了传统中药如PM的作用。虽然进一步的研究对验证和理解这些影响是必要的，但已确定的草药显示出缓解疲劳的潜力。

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引用次数: 0

The effect of Lapis Judaicus compared with hydrochlorothiazide on kidney stones 比较犹太青金石与氢氯噻嗪治疗肾结石的疗效

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-08 DOI: 10.1016/j.aimed.2025.100583

Elham Akbarzadeh , Mohammad Mehdi Hosseini , Zohreh Abolhassanzadeh , Ebrahim Fallahzadeh Abarghooei , Shahrokh Ezzatzadegan Jahromi , Seyed Hamed Jafari , Alireza Mohamadian , Amir Mohammad Jaladat

Introduction

More than one million referrals to the emergency department worldwide is related to kidney stones. Lapis Judaicus (LJ) as an ancient treatment of kidney stones has been described by Dioscorides, Galen, and some famaous Iranian scholars such as Ibn Sina, Razi, and Ahvazi and currently is used in the folk medicine market of Iran, Pakistan, Afghanistan, and India. Despite its popularity in some regions, few studies have evaluated its effect on renal stones. In this study, we investigated the effect of LJ in comparison with hydrochlorothiazide (HCTZ) on renal stone.

Methods

Seventy–seven adult patients with a stable and opaque kidney stones equal or greater than 5 mm, who received no treatment for their kidney stone in the past month were recruited and randomized into three groups: A) HCTZ (12.5 mg capsules two each morning, N = 25), B) LJ+HCTZ (1gr capsules two each morning +12.5 mg HCTZ N = 27), and C) LJ (1gr capsules two each morning, N = 25) for 2 months. After the intervention (the end of 2 months), checking serum and urinary parameters and kidney ultrasound were performed and compared with pre-intervention findings.

Results

A significant decrease was found in the size of renal stones in groups B and C. LJ alone or with hydrochlorothiazide did not cause any significant change in serum and urine parameters between before and after treatment (P > 0.05).

Conclusion

The stone sizes changed significantly in two groups that received LJ, compared with HCTZ, without any significant effect on liver enzymes or renal function.

导读：全世界有超过100万的急诊患者与肾结石有关。犹太教青金石（LJ）作为一种古老的治疗肾结石的药物被迪奥斯科里德、盖伦和一些著名的伊朗学者如伊本·西纳、拉齐、阿瓦齐描述，目前在伊朗、巴基斯坦、阿富汗和印度的民间医药市场上使用。尽管它在一些地区很受欢迎，但很少有研究评估它对肾结石的影响。在这项研究中，我们研究了LJ与氢氯噻嗪（HCTZ）对肾结石的影响。MethodsSeventy-seven成人患者一个稳定的和不透明的肾结石等于或大于5 mm,他们没有得到治疗肾结石在过去一个月被召集来,随机分为三组:a) HCTZ(12.5 毫克胶囊两个每天早晨,N = 25),B) LJ + HCTZ (1 gr胶囊每天早上两个+ 12.5 毫克HCTZ N = 27),和C) LJ (1 gr胶囊两个每天早晨,N = 25)2个月。干预后（2个月结束）行血清、尿参数及肾脏超声检查，并与干预前比较。结果B组和c组患者肾结石大小均明显减小，单独使用LJ或联合使用氢氯噻嗪治疗前后血清和尿液参数无显著变化（P >； 0.05）。结论LJ组与HCTZ组相比，结石大小有明显变化，对肝酶及肾功能无明显影响。

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引用次数: 0

Comparative effects of thyme and ginger on gastrointestinal symptom relief: A randomized controlled trial 百里香和生姜对胃肠道症状缓解的比较作用：一项随机对照试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-08 DOI: 10.1016/j.aimed.2025.100584

Mohammad Rostamkhani , Masoud Etedali , Azam Malek Hoseini , Hooman Mohammad talebi

Introduction

Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder with significant impacts on quality of life. Conventional treatments offer limited relief, prompting interest in herbal remedies. This study evaluates the efficacy of ginger (Zingiber officinale) and Shirazi thyme (Zataria multiflora) in managing IBS symptoms.

Methods

This double-blind, randomized clinical trial was conducted after obtaining the ethical approval. Sixty-six IBS patients, aged 20–50, were randomly assigned to three groups: ginger (1 g/day), Shirazi thyme (20 mg twice daily), or placebo (brown sugar) for four weeks. Participants completed the Gastrointestinal Symptom Rating Scale (GSRS) before and after treatment. Randomization minimized IBS subtype bias, and identical capsules ensured blinding. Data were analyzed using SPSS v22 to assess symptom changes.

Results

A total of 66 participants (42.4 % male, mean age 35.6 years) were enrolled and evenly allocated across the three groups. A one-way ANOVA revealed a significant group effect on post-intervention GSRS scores (F (2,63) = 85.2, p < 0.001). Post hoc analyses showed that the ginger group reported significantly lower GSRS scores compared with both the control (mean difference = −12.77, p < 0.001) and thyme groups (mean difference = −8.72, p < 0.001). Additionally, the thyme group had significantly lower scores than the control (mean difference = −4.05, p = 0.036). Only the ginger group showed a significant pre–post reduction in GSRS scores (p < 0.001).

Conclusion

Ginger significantly improved IBS symptoms, while thyme had a modest effect. Ginger appears promising as a complementary treatment, whereas thyme requires further investigation.

肠易激综合征（IBS）是一种常见的胃肠道疾病，对生活质量有显著影响。传统疗法的缓解效果有限，这促使人们对草药产生了兴趣。本研究评估生姜（Zingiber officinale）和百里香（Zataria multiflora）对IBS症状的治疗效果。方法获得伦理批准后进行双盲随机临床试验。66名年龄在20 - 50岁之间的IBS患者被随机分为三组：生姜（1 g/天），Shirazi百里香（20 mg /天两次）或安慰剂（红糖），持续四周。参与者在治疗前后完成胃肠症状评定量表（GSRS）。随机化最小化了IBS亚型偏倚，相同的胶囊确保了盲法。使用SPSS v22对数据进行分析，评估症状变化。结果共入组66例，男性42.4 %，平均年龄35.6岁。单因素方差分析显示干预后GSRS评分有显著的组效应（F(2,63) = 85.2,p <； 0.001）。事后分析显示，生姜组的GSRS评分显著低于对照组（平均差异= - 12.77,p <； 0.001）和百里香组（平均差异= - 8.72,p <； 0.001）。此外，百里香组得分显著低于对照组（平均差异= - 4.05,p = 0.036）。只有生姜组在GSRS评分中表现出显著的前后降低（p <； 0.001）。结论生姜能显著改善IBS症状，而百里香效果一般。生姜作为补充疗法似乎很有希望，而百里香则需要进一步研究。

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引用次数: 0

From microbes to medals: Integrative gut microbiome interventions for athletic excellence 从微生物到奖牌：综合肠道微生物组干预运动卓越

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-08 DOI: 10.1016/j.aimed.2025.100582

Emad M. Abdallah, Ahmed Emad Mohamed, Ozwan Moatasem Hassan, Sameh Yasser Amin, Waleed Hamid Aghbash

引用次数: 0

Effect of geriatric massage in elderly patients with type 2 diabetes: A randomized controlled trial 老年按摩对老年2型糖尿病患者的疗效：一项随机对照试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-08 DOI: 10.1016/j.aimed.2025.100581

Emine Apaydın , Sevilay Hintistan

Objective

This randomized controlled trial examined the effects of geriatric massage on diabetes-related symptoms and blood parameters in older adults with type 2 diabetes. The study included 59 participants (29 in the geriatric massage group and 30 in the control group).

Methods

Data were collected using the Older Adults Information Form, the Diabetes Symptoms Checklist, and the Blood Parameters Monitoring Form. Participants in the intervention group received 30-minute geriatric massage sessions twice weekly for 12 weeks. Statistical analyses included the Shapiro–Wilk test, Mann–Whitney U test, ANOVA, Friedman test, Wilcoxon test, Chi-square test, Fisher–Freeman–Halton test, Greenhouse–Geisser correction, Bonferroni adjustment, and paired and independent t-tests.

Results

Compared with the control group, participants receiving geriatric massage showed a significant reduction in diabetes symptoms (p < 0.001), an increase in HDL cholesterol levels, and decreases in other blood parameters (p < 0.05).

Discussion

Geriatric massage may help reduce diabetes symptoms and improve selected blood parameters in older adults with type 2 diabetes.

目的探讨老年按摩对老年2型糖尿病患者糖尿病相关症状和血液参数的影响。该研究包括59名参与者（老年按摩组29名，对照组30名）。方法采用《老年人信息表》、《糖尿病症状表》和《血液参数监测表》进行资料收集。干预组的参与者每周接受两次30分钟的老年按摩，持续12周。统计分析包括Shapiro-Wilk检验、Mann-Whitney U检验、方差分析、Friedman检验、Wilcoxon检验、卡方检验、Fisher-Freeman-Halton检验、Greenhouse-Geisser校正、Bonferroni调整、配对和独立t检验。结果与对照组相比，接受老年按摩的参与者糖尿病症状明显减轻（p <； 0.001），高密度脂蛋白胆固醇水平升高，其他血液参数降低（p <； 0.05）。老年按摩可以帮助老年2型糖尿病患者减轻糖尿病症状并改善选定的血液参数。

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引用次数: 0

Ethnobotanical survey and anthelmintic activity of Origanum compactum and Trigonella foenum graecum extracts against Ascaris 土茯苓和葫芦巴提取物对蛔虫的民族植物学调查及驱虫活性

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-10-02 DOI: 10.1016/j.aimed.2025.100580

Sana Chaoua , Samia Boussaa , Zuhair Dardona , Ali Boumezzough , Mohamed Hafidi

Helminthiasis remains a ubiquitous parasitic disease worldwide, affecting a substantial proportion of the global population. However, the growing problem of anthelmintic resistance, combined with the high cost and limited accessibility of conventional pharmaceuticals, has intensified the search for plant-based alternatives in parasite control strategies. An ethnobotanical survey was carried out to identify medicinal plants used for treating diarrhea and parasitic infections in Morocco. Informed by ethnobotanical evidence, Origanum compactum (oregano) and Trigonella foenum-graecum (fenugreek) were selected for an in vitro assessment of their anthelmintic properties. The efficacy of their ethanolic extracts was systematically evaluated against Ascaris eggs across graded concentrations (1.25, 2.5, 5, and 10 mg/mL). Furthermore, distilled water and albendazole were employed as negative and positive controls, respectively. In addition, acute toxicity assays and comprehensive phytochemical screening were performed for plant extracts. The statistical significance of the observed anthelmintic activity was subsequently evaluated using analysis of variance (ANOVA test). The results revealed that the ethanolic extracts of O. compactum and T. foenum-graecum were non-toxic in acute oral toxicity assays, with LD₅₀ values exceeding 5 g/kg. At a concentration of 10 mg/mL, both extracts exhibited pronounced ovicidal activity against Ascaris eggs, achieving mortality rates of 97.73 % and 100 %, respectively. These findings indicate that the aerial parts of both species possess substantial anthelmintic potential, likely attributable to the bioactive secondary metabolites detected through phytochemical screening.

蛔虫病仍然是世界范围内普遍存在的一种寄生虫病，影响着全球很大一部分人口。然而，越来越严重的驱虫抗药性问题，加上传统药物的高成本和有限的可及性，已经加强了在寄生虫控制战略中寻找基于植物的替代品。开展了民族植物学调查，以确定摩洛哥用于治疗腹泻和寄生虫感染的药用植物。根据民族植物学证据，选择牛至（Origanum compactum）和葫芦巴（Trigonella foenum-graecum）进行体外驱虫特性评估。系统评估了不同浓度（1.25、2.5、5和10 mg/mL）的乙醇提取物对蛔虫卵的作用。以蒸馏水和阿苯达唑分别作为阴性对照和阳性对照。此外，还对植物提取物进行了急性毒性试验和综合植物化学筛选。随后使用方差分析（ANOVA检验）评估观察到的驱虫虫活性的统计显著性。结果表明，O. compactuum和T. foenum-graecum的乙醇提取物在急性口服毒性试验中无毒，LD₅0值超过5 g/kg。在浓度为10 mg/mL时，两种提取物对蛔虫卵均表现出明显的杀卵活性，死亡率分别为97.73% %和100% %。这些发现表明，这两个物种的地上部分具有很大的驱虫潜力，可能是由于通过植物化学筛选检测到的生物活性次生代谢物。

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引用次数: 0

Clinical study on the correlation between syndrome types and Traditional Chinese Medicine constitution in 409 cases of female infertility 409例女性不孕症证型与中医体质相关性的临床研究

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-22 DOI: 10.1016/j.aimed.2025.100579

Gao Zhuwei , Miao Xiaoling , Hu Yixiao , Yu Jiannan , Feng Jiaxing , Liu Yang , Wu Xiaoke

Objective

This research aims to investigate the patterns and interconnections between infertility syndrome classifications and Traditional Chinese Medicine (TCM) constitutional profiles.

Methods

A retrospective analysis was conducted to categorize cases that fulfilled the eligibility criteria, followed by an examination of the statistical outcomes.

Results

The findings revealed that among the 409 infertility cases, the most prevalent TCM syndrome was Kidney Deficiency Syndrome, with 242 cases (59.2 %); Balanced Constitution accounted for 118 cases (28.9 %), while Yang Deficiency Constitution was the most common among the Biased Constitutions, with 86 cases (21 %). The influencing factors included BMI, disease duration, age, and ovarian factors. Yang Deficiency Constitution (64 cases) was more frequent in the high-incidence Kidney Deficiency Syndrome.

Conclusion

Kidney Deficiency Syndrome was the most common TCM syndrome in female infertility, and Yang Deficiency Constitution was more prevalent among Biased Constitutions.

目的探讨不孕不育综合征分型与中医体质特征的关系及其规律。方法采用回顾性分析对符合入选标准的病例进行分类，并对统计结果进行检验。结果409例不孕症患者中，以肾虚证最为常见，共242例（59.2% %）；平衡型体质118例（28.9 %），偏倚型体质中阳虚型体质最多，有86例（21 %）。影响因素包括BMI、病程、年龄和卵巢因素。阳虚体质以高发肾虚证多见（64例）。结论肾虚证是女性不孕症最常见的中医证候，偏颇体质以阳虚体质多见。

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引用次数: 0

An investigation into the sensitivity and specificity of iridology for detecting abnormalities in the female reproductive system: A cross-sectional observational study 虹膜学检测女性生殖系统异常的敏感性和特异性研究：一项横断面观察研究

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-13 DOI: 10.1016/j.aimed.2025.100572

A. Aishwarya , A. Mooventhan , R. Arunthathi , L. Nivethitha , N. Manavalan

Background

Iridology is an assessment technique that involves examining the iris to identify potential pathological disorders. Despite being practiced for centuries, the effectiveness of iris diagnosis as a diagnostic tool remains controversial, primarily due to limited empirical evidence supporting its claims. Thus, there is a critical need for scientific studies to provide evidence regarding the efficacy of iridology assessment. This study aimed to determine the sensitivity and specificity of iridology assessment in detecting abnormalities in the female reproductive system.

Materials and methods

This cross-sectional observational study included 100 female participants. All participants underwent an iris examination, a clinical assessment, and ultrasonography. The results from these investigations were compared, and sensitivity and specificity rates were calculated using standard formulas.

Results

The study found that iridology assessment demonstrated a sensitivity of 92 % and a specificity of 56 % in detecting abnormalities within the female reproductive system.

Conclusion

The findings suggest that iridology assessment may serve as a potentially useful complementary tool for detecting abnormalities in the female reproductive system. However, further research is essential to confirm the effectiveness of this method and to explore its potential benefits and limitations in gynecological diagnosis. Continued scientific investigation is crucial to establish the role of iridology assessment in enhancing gynecological healthcare.

背景：虹膜学是一种评估技术，包括检查虹膜以识别潜在的病理疾病。尽管已经实践了几个世纪，虹膜诊断作为诊断工具的有效性仍然存在争议，主要是由于有限的经验证据支持其主张。因此，迫切需要进行科学研究，为虹膜学评估的有效性提供证据。本研究旨在确定虹膜学评估在检测女性生殖系统异常中的敏感性和特异性。材料与方法本研究包括100名女性参与者。所有的参与者都接受了虹膜检查、临床评估和超声检查。比较这些调查的结果，并使用标准公式计算敏感性和特异性。结果虹膜学检测女性生殖系统异常的灵敏度为92 %，特异性为56 %。结论虹膜学评估可作为女性生殖系统异常检测的辅助工具。然而，需要进一步的研究来证实这种方法的有效性，并探讨其在妇科诊断中的潜在益处和局限性。持续的科学调查对于确立虹膜学评估在加强妇科保健中的作用至关重要。

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引用次数: 0

Ledum palustre 200cH in preventing injection site pain and tenderness following COVID-19 vaccination: Interim results of a double-blind, randomized, placebo-controlled trial 棕榈叶Ledum palustre 200cH预防COVID-19疫苗接种后注射部位疼痛和压痛：一项双盲、随机、安慰剂对照试验的中期结果

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-11 DOI: 10.1016/j.aimed.2025.100574

Subhranil Saha , Abhijit Rana , Aritra Roy Chowdhury , Satyajit Naskar , Pulakendu Bhattacharya , Subhasish Ganguly , Sangita Saha , Amitava Paul , Shyamal Kumar Mukherjee

Background

The COVID-19 vaccine frequently results in cutaneous side effects, such as redness and swelling, near the injection site. This trial was carried out to determine whether Ledum palustre 200cH is more effective than a placebo at preventing injection site pain and tenderness after the COVID-19 vaccination.

Methods

This one-month, double-blind, randomized, placebo-controlled, parallel-arm clinical trial was conducted at the vaccination department of a homeopathic hospital in West Bengal, India. Despite the desired sample size being projected at 218, only 122 participants could be enrolled because of the abrupt termination of the COVID-19 immunization campaign in India. Interventions were Ledum palustre 200cH (n = 61) or placebos with the same appearance (n = 61). The main outcome measure was the degree of pain and tenderness at the injection site was measured on days 1, 2, 3, 5, and 7, then once a week for a month, using a 0–100 mm visual analog scale (VAS).

Results

The trial was terminated prematurely. The Kaplan-Meier survival distributions revealed that the time to resolution of pain was statistically significantly earlier in the verum group (median: 2 days, 95 % confidence interval (CI) 1.7–2.3) than placebo (median: 3 days, 95 % CI 2.6–3.4); Mantel-Cox log-rank test: χ₁² = 21.632, p < 0.001. Similar trends were revealed by earlier resolution of tenderness favoring verum (median: 2 days, 95 % CI 1.7–2.3) against placebo (median: 3 days, 95 % CI 2.5–3.4); Mantel-Cox log-rank test: χ₁² = 20.172, p < 0.001.

Conclusion

Ledum palustre 200cH produced significantly better effects than placebos by earlier resolution of pain and tenderness in injection sites following COVID-19 vaccination; however, these results should be interpreted with caution because the trial was underpowered. Conclusive and robust trials should be undertaken to validate the findings.

Trial registration

CTRI/2022/10/046839; UTN: U1111-1284-2437.

背景：COVID-19疫苗经常导致注射部位附近的皮肤副作用，如红肿。本试验旨在确定Ledum palustre 200cH在预防COVID-19疫苗接种后注射部位疼痛和压痛方面是否比安慰剂更有效。方法在印度西孟加拉邦一家顺势疗法医院疫苗部进行为期一个月的双盲、随机、安慰剂对照、平行对照临床试验。尽管预期样本量为218人，但由于印度的COVID-19免疫运动突然终止，只能招募122名参与者。干预措施为Ledum palustre 200cH （n = 61）或具有相同外观的安慰剂（n = 61）。主要结果测量是注射部位的疼痛和压痛程度，于第1、2、3、5和7天测量，然后每周一次，持续一个月，使用0-100 mm视觉模拟量表（VAS）。结果试验提前终止。Kaplan-Meier生存分布显示，verum组疼痛缓解时间（中位数：2天，95% %置信区间（CI） 1.7-2.3）显著早于安慰剂组（中位数：3天，95% % CI 2.6-3.4）；Mantel-Cox log-rank检验：χ12 = 21.632,p <； 0.001。与安慰剂（中位数：3天，95% % CI 2.5-3.4）相比，早期缓解的压痛倾向于verum（中位数：2天，95% % CI 1.7-2.3）也显示了类似的趋势；Mantel-Cox log-rank检验：χ12 = 20.172,p <； 0.001。结论palustre 200cH对新冠肺炎疫苗接种后注射部位疼痛和压痛的早期缓解效果明显优于安慰剂；然而，这些结果应该谨慎解释，因为试验的动力不足。应该进行结论性和强有力的试验来验证这些发现。审判registrationCTRI / 2022/10/046839;UTN: u1111 - 1284 - 2437。

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引用次数: 0

Effect of selected acupuncture points on lung functions and inflammatory markers in patients with asthma – An interventional study 选择穴位对哮喘患者肺功能和炎症标志物的影响——一项介入性研究

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-10 DOI: 10.1016/j.aimed.2025.100573

S. Sasikumar , Thanalakshmi Jagadeesan , Arbind Kumar Choudhary , Sundareswaran Loganathan , V. Venugopal , K. Bincy , Maheshkumar Kuppusamy

Background

Acupuncture is commonly utilized as an alternative method for managing bronchial asthma and has the added benefit of being cost-effective while improving the quality of life. Although previous studies have demonstrated the effectiveness of acupuncture in treating patients with bronchial asthma, there is a lack of evidence regarding its impact on inflammatory markers associated with the condition. Therefore, the purpose of this study was to assess the effects of acupuncture treatment on pulmonary function and blood inflammatory markers in patients diagnosed with bronchial asthma.

Methods

n this particular study, a group of 15 patients diagnosed with mild or moderate bronchial asthma were included. These patients underwent acupuncture treatment sessions lasting 20 min each, once a day, for a duration of one month. Before and after the treatment period, patients' pulmonary functions and inflammatory markers were estimated.

Results

The results of the study revealed significant improvements in pulmonary function parameters following acupuncture treatment in patients with asthma. Specifically, there was a notable increase in Forced Vital Capacity (FVC) and the ratio of Forced Expiratory Volume in one second (FEV1) to FVC. Additionally, acupuncture was associated with increased levels of Interleukin-10 (IL-10) and Dehydroepiandrosterone sulfate (DHEA-S), which is a sulphated metabolite of dehydroepiandrosterone. Also, there was a significant decrease in levels of Tumor Necrosis Factor-alpha (TNF-α), cortisol, and salivary alpha amylase (sAA).

Conclusion

These findings suggest that acupuncture treatment in patients with asthma may lead to improvements in pulmonary function and modulation of inflammatory markers. The increase in IL-10 and DHEA-S, along with the decrease in TNF-α, cortisol, and sAA, may indicate a potential anti-inflammatory effect of acupuncture in asthma management.

背景：针灸通常被用作治疗支气管哮喘的一种替代方法，并且在提高生活质量的同时具有成本效益。虽然以前的研究已经证明了针灸治疗支气管哮喘患者的有效性，但缺乏关于针灸对哮喘相关炎症标志物影响的证据。因此，本研究的目的是评估针灸治疗对支气管哮喘患者肺功能和血液炎症标志物的影响。方法本研究纳入15例轻中度支气管哮喘患者。这些患者接受针灸治疗，每次20 分钟，每天一次，持续一个月。治疗前后分别评估患者肺功能和炎症指标。结果针灸治疗后哮喘患者肺功能指标有明显改善。具体而言，用力肺活量（FVC）和用力呼气量（FEV1）与FVC的比值显著增加。此外，针灸与白细胞介素-10 （IL-10）和硫酸脱氢表雄酮（DHEA-S）水平升高有关，后者是脱氢表雄酮的硫酸代谢物。此外，肿瘤坏死因子-α (TNF-α)、皮质醇和唾液α淀粉酶（sAA）水平也显著降低。结论针刺治疗哮喘患者可改善肺功能，调节炎症标志物。IL-10和DHEA-S的升高，以及TNF-α、皮质醇和sAA的降低，可能表明针灸在哮喘治疗中具有潜在的抗炎作用。

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