Pub Date : 2025-07-11DOI: 10.1016/j.aimed.2025.100554
Jing Zou, Rao Fu, Lixia Zhang
Objective
To evaluate the impact of the compound Wuwei ironing pack combined with the ERAS (Enhanced Recovery After Surgery) management protocol on postoperative gastrointestinal recovery in hepatocellular carcinoma patients.
Methods
A convenience sampling approach was used to recruit liver cancer patients from the hepatobiliary and pancreatic surgery ward of our hospital between June 2023 and February 2024. A total of 159 patients were randomized into three groups: (1) the control group, which received standard ERAS management; (2) the fennel ironing pack group, which used an independent fennel-based physiotherapy formula; and (3) the compound Wuwei ironing pack group, which utilized a physiotherapy pack developed by the Traditional Chinese Medicine Department. This pack contained five traditional Chinese herbs: fennel, dried tangerine peel, Fructus Aurantii Immaturus, Magnoliae Officinalis Cortex, and malt. The groups were compared based on time to first defecation, length of hospital stay, incidence of infection, and nutritional indicators.
Results
The compound Wuwei ironing pack group demonstrated significantly shorter time to first defecation and postoperative hospital stay compared to the fennel group and the control group (both P < 0.05).
Conclusion
The compound Wuwei traditional Chinese medicine ironing pack demonstrated better recovery outcomes compared to fennel physiotherapy and standard ERAS management. It reduced hospital stay, is simple to use, safe, and suitable for clinical application.
目的评价复方武味熨烫包联合ERAS （Enhanced Recovery After Surgery）管理方案对肝癌患者术后胃肠功能恢复的影响。方法采用方便抽样方法，于2023年6月至2024年2月在我院肝胆胰外科病房招募肝癌患者。159例患者随机分为3组：(1)对照组，采用ERAS标准管理；(2)茴香熨烫包组，使用独立的以茴香为基础的理疗配方；(3)复方武味熨烫包组，采用中医科研制的理疗包。这包含有五种传统中药：茴香，干陈皮，金果仁，厚朴皮和麦芽。根据首次排便时间、住院时间、感染发生率和营养指标对各组进行比较。结果复方五味熨烫包组患者首次排便时间和术后住院时间明显短于茴香组和对照组（P均为 <； 0.05）。结论复方武味中药熨烫包与茴香理疗及ERAS标准治疗相比，具有更好的康复效果。缩短住院时间，使用简单，安全，适合临床应用。
{"title":"Effects of compound Wuwei ironing pack combined with ERAS management mode on the recovery of gastrointestinal function after primary hepatocellular carcinoma surgery","authors":"Jing Zou, Rao Fu, Lixia Zhang","doi":"10.1016/j.aimed.2025.100554","DOIUrl":"10.1016/j.aimed.2025.100554","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of the compound Wuwei ironing pack combined with the ERAS (Enhanced Recovery After Surgery) management protocol on postoperative gastrointestinal recovery in hepatocellular carcinoma patients.</div></div><div><h3>Methods</h3><div>A convenience sampling approach was used to recruit liver cancer patients from the hepatobiliary and pancreatic surgery ward of our hospital between June 2023 and February 2024. A total of 159 patients were randomized into three groups: (1) the control group, which received standard ERAS management; (2) the fennel ironing pack group, which used an independent fennel-based physiotherapy formula; and (3) the compound Wuwei ironing pack group, which utilized a physiotherapy pack developed by the Traditional Chinese Medicine Department. This pack contained five traditional Chinese herbs: fennel, dried tangerine peel, Fructus Aurantii Immaturus, Magnoliae Officinalis Cortex, and malt. The groups were compared based on time to first defecation, length of hospital stay, incidence of infection, and nutritional indicators.</div></div><div><h3>Results</h3><div>The compound Wuwei ironing pack group demonstrated significantly shorter time to first defecation and postoperative hospital stay compared to the fennel group and the control group (both P < 0.05).</div></div><div><h3>Conclusion</h3><div>The compound Wuwei traditional Chinese medicine ironing pack demonstrated better recovery outcomes compared to fennel physiotherapy and standard ERAS management. It reduced hospital stay, is simple to use, safe, and suitable for clinical application.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100554"},"PeriodicalIF":1.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mitragyna speciosa Korth, commonly known as kratom, is a native medicinal plant of Southeast Asia, including Indonesia, known for its opioid-like effects. The traditional brewing of kratom has been a longstanding folk remedy, especially within the local community in Indonesia. Our study aims to evaluate the health and biochemical impacts of kratom consumption among regular users in the local community of Putussibau District, Kapuas Hulu Regency, Borneo, Indonesia.
Methods
A total of 75 participants were involved in this cross-sectional study. All surveys were carried out through face-to-face interviews to gather information on participants' sociodemographic characteristics and their history of kratom use. Clinical chemistry analysis (n = 60 participants) was then performed to assess potential alterations in the biochemical parameters of kratom users.
Results
The majority of participants perceived that kratom consumption positively influenced their overall health status. However, these perceived benefits may not consistently supported by corresponding biochemical findings. Kratom users showed an inclination towards elevated LDL and TG levels compared to the reference levels (73 % (44/60) and 58 % (35/60) of the total participants, respectively), as well as increased hs-CRP (62 % (36/60) of the total participants). Notably, individuals consuming higher doses of kratom tended to have a higher BUN levels.
Conclusion
In summary, our study suggests that, in general, individuals who regularly consume brewed kratom over an extended period did not experience undesirable effects. Nevertheless, it is crucial to highlight the potential adverse effects of kratom consumption, including alterations in lipid profile, kidney function, and inflammatory response.
{"title":"Exploring the health and biochemical effects of kratom (Mitragyna speciosa) consumption within the local community of Putussibau district, Borneo, Indonesia","authors":"Mery Budiarti , Lusi Kristiana , Pramita Andarwati , Aris Yulianto , Rohmat Mujahid , Slamet Wahyono , Zulvikar Syambani Ulhaq","doi":"10.1016/j.aimed.2025.100555","DOIUrl":"10.1016/j.aimed.2025.100555","url":null,"abstract":"<div><h3>Background</h3><div><em>Mitragyna speciosa</em> Korth, commonly known as kratom, is a native medicinal plant of Southeast Asia, including Indonesia, known for its opioid-like effects. The traditional brewing of kratom has been a longstanding folk remedy, especially within the local community in Indonesia. Our study aims to evaluate the health and biochemical impacts of kratom consumption among regular users in the local community of Putussibau District, Kapuas Hulu Regency, Borneo, Indonesia.</div></div><div><h3>Methods</h3><div>A total of 75 participants were involved in this cross-sectional study. All surveys were carried out through face-to-face interviews to gather information on participants' sociodemographic characteristics and their history of kratom use. Clinical chemistry analysis (n = 60 participants) was then performed to assess potential alterations in the biochemical parameters of kratom users.</div></div><div><h3>Results</h3><div>The majority of participants perceived that kratom consumption positively influenced their overall health status. However, these perceived benefits may not consistently supported by corresponding biochemical findings. Kratom users showed an inclination towards elevated LDL and TG levels compared to the reference levels (73 % (44/60) and 58 % (35/60) of the total participants, respectively), as well as increased hs-CRP (62 % (36/60) of the total participants). Notably, individuals consuming higher doses of kratom tended to have a higher BUN levels.</div></div><div><h3>Conclusion</h3><div>In summary, our study suggests that, in general, individuals who regularly consume brewed kratom over an extended period did not experience undesirable effects. Nevertheless, it is crucial to highlight the potential adverse effects of kratom consumption, including alterations in lipid profile, kidney function, and inflammatory response.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100555"},"PeriodicalIF":1.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aims to examine the relationship between caffeine consumption and sleep quality among healthcare professionals.
Method
This cross-sectional study was conducted on 98 healthcare professionals working at Balıkesir Havran State Hospital. Participants' caffeine consumption levels were assessed using the Caffeine Consumption Frequency Questionnaire, and their sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). The data were analyzed using the SPSS 22.0 statistical software package. Descriptive statistics, student’s t-test, and linear regression analyses were performed, with a significance level set at p < 0.05.
Results
The average daily caffeine consumption among participants was found to be 279.12 ± 168.50 mg. Although the mean caffeine intake was slightly higher among females, this difference was not statistically significant. 57.1 % of the participants were evaluated as having poor sleep quality. According to the regression analysis, daily caffeine consumption was positively associated with sleep duration (p < 0.05), but no significant relationship was found with other components of sleep quality.
Conclusion
This study suggests that daily caffeine consumption among healthcare professionals may have a positive effect on sleep duration, but does not have a significant impact on overall sleep quality.
{"title":"The relationship between caffeine consumption and self-reported sleep quality among healthcare professionals","authors":"Sedat Arslan , Kevser TARI Selcuk , Kübra Betül Kirbiyik , Nuh Şerbetçi̇","doi":"10.1016/j.aimed.2025.100553","DOIUrl":"10.1016/j.aimed.2025.100553","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to examine the relationship between caffeine consumption and sleep quality among healthcare professionals.</div></div><div><h3>Method</h3><div>This cross-sectional study was conducted on 98 healthcare professionals working at Balıkesir Havran State Hospital. Participants' caffeine consumption levels were assessed using the Caffeine Consumption Frequency Questionnaire, and their sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). The data were analyzed using the SPSS 22.0 statistical software package. Descriptive statistics, student’s t-test, and linear regression analyses were performed, with a significance level set at p < 0.05.</div></div><div><h3>Results</h3><div>The average daily caffeine consumption among participants was found to be 279.12 ± 168.50 mg. Although the mean caffeine intake was slightly higher among females, this difference was not statistically significant. 57.1 % of the participants were evaluated as having poor sleep quality. According to the regression analysis, daily caffeine consumption was positively associated with sleep duration (p < 0.05), but no significant relationship was found with other components of sleep quality.</div></div><div><h3>Conclusion</h3><div>This study suggests that daily caffeine consumption among healthcare professionals may have a positive effect on sleep duration, but does not have a significant impact on overall sleep quality.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100553"},"PeriodicalIF":1.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Traditional Iranian medicine classifies individuals based on temperament (Mizaj), defined by hot-cold and dry-wet attributes, which are thought to influence health and disease susceptibility. This study investigates the relationship between temperaments and anthropometric variables, aiming to provide a quantitative, evidence-based foundation for traditional medicine. A cross-sectional study conducted with 200 healthy males aged 20–30. We recorded a number of anthropometric measurements, including height, weight, skinfold thickness, and hip (HC) and waist (WC) circumferences. Body Mass Index (BMI) and body fat index (BFI) were calculated. Participants completed a validated temperament assessment questionnaire. Participants were categorized into four groups: Warm-Dry (WD) (28 %), Warm-Wet (WW) (18 %), Cold-Dry (CD) (17.3 %), and Cold-Wet (CW) (36.7 %). Significant differences were observed in weight, BMI, BFI, waist, and hip circumferences among the groups. The CW group had the highest average weight (88.35 kg), BFI (25.1 %), BMI (27.93 kg/m²), while the WD group had the lowest weight (69.39 kg), BMI (21.13 kg/m²), BFI (14.8 %), ROC curve analysis identified pelvic circumference as the optimal predictor for cold-warm temperament classification, with a cut-off value of 99.5 cm, for dry-wet temperament, BFI was the reasonable predictor, with a cut-off of 20.10 %. The findings are consistent with traditional Iranian medicine principles, which associate warm-wet temperaments with larger body sizes and greater soft tissue mass, while cold or dry temperaments correlate with a leaner physique. These findings support the using anthropometric indices as objective measures for temperament classification, offering a scientific basis for traditional Iranian medicine and enhancing personalized health interventions.
{"title":"Anthropometric indices correlates of temperament (Mizaj) in traditional medicine: A cross-sectional study of Iranian males","authors":"Soheil Ashouri , Mohammad Mahdi Ahmadian-Attari , Malihe Farid , Hamid Shamsi Baghbanan , Simin Mahakizadeh","doi":"10.1016/j.aimed.2025.100536","DOIUrl":"10.1016/j.aimed.2025.100536","url":null,"abstract":"<div><div>Traditional Iranian medicine classifies individuals based on temperament (Mizaj), defined by hot-cold and dry-wet attributes, which are thought to influence health and disease susceptibility. This study investigates the relationship between temperaments and anthropometric variables, aiming to provide a quantitative, evidence-based foundation for traditional medicine. A cross-sectional study conducted with 200 healthy males aged 20–30. We recorded a number of anthropometric measurements, including height, weight, skinfold thickness, and hip (HC) and waist (WC) circumferences. Body Mass Index (BMI) and body fat index (BFI) were calculated. Participants completed a validated temperament assessment questionnaire. Participants were categorized into four groups: Warm-Dry (WD) (28 %), Warm-Wet (WW) (18 %), Cold-Dry (CD) (17.3 %), and Cold-Wet (CW) (36.7 %). Significant differences were observed in weight, BMI, BFI, waist, and hip circumferences among the groups. The CW group had the highest average weight (88.35 kg), BFI (25.1 %), BMI (27.93 kg/m²), while the WD group had the lowest weight (69.39 kg), BMI (21.13 kg/m²), BFI (14.8 %), ROC curve analysis identified pelvic circumference as the optimal predictor for cold-warm temperament classification, with a cut-off value of 99.5 cm, for dry-wet temperament, BFI was the reasonable predictor, with a cut-off of 20.10 %. The findings are consistent with traditional Iranian medicine principles, which associate warm-wet temperaments with larger body sizes and greater soft tissue mass, while cold or dry temperaments correlate with a leaner physique. These findings support the using anthropometric indices as objective measures for temperament classification, offering a scientific basis for traditional Iranian medicine and enhancing personalized health interventions.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100536"},"PeriodicalIF":1.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sexually Transmitted Disease (STDs) remain a significant global health issue, particularly affecting women due to biological and sociocultural factors. Traditional medicine has been widely used in the management of sexually transmitted disease due to its accessibility, affordability and cultural acceptance. However, it has several limitations that challenge its efficacy and reliability due to absence of rigorous scientific validation and clinical trials. The study was undertaken to explore the integration of traditional medicine with modern approaches to STD management. The purpose of the review to bridge the gap in knowledge between traditional medicinal practices and modern interventions through a comparative analysis. It also aims to address the gaps in healthcare access, particularly in underprivileged regions where economic constraints limit the availability of conventional allopathic treatments.
Methods
The study employed systematic literature review methodology to explore the application of traditional medicine in STD management. Databases such as Pub Med, Google scholar, science direct, web of science was searched from up to January 2024. Search terms included “traditional medicine, “STDs”, “medicinal plants” and specific plant names (eg: Neem, Echinea, Aloe vera). A total of 381 articles were initially retrieved and duplicates were removed. Inclusion criteria focused on studies providing in-vitro and in-vivo data for STD treatment, cultural applications and integration with modern medicine. Relevant were extracted using a structural database, capturing the plant species, active compounds, mechanisms of action and therapeutic outcomes. Cross referencing with WHO and national databases ensured the inclusion of the latest prevalence and management.
Results
The findings suggest practice of traditional medicines including the use of specific plants and holistic approaches offers valuable benefits in the management of STDs and enhancing overall wellbeing. The integration of traditional medicine with modern health practices provides a comprehensive approach that addresses not only the physical aspects of health but also the emotional and social dimension. The limitations of the findings presented in the review primarily stem from the limited number of clinical trials included. Such studies primarily elucidate theoretical mechanisms of action and biological pathways. However, these results cannot be directly extrapolated to clinical outcomes or therapeutic benefits in human populations, highlighting the need for caution when interpreting the transitional potential of these findings.
Discussion
The review highlights the importance of combine approach of traditional medicine with modern clinical practices to create an inclusive and culturally sensitive approach to STD management and female health. The signi
性传播疾病（std）仍然是一个重大的全球健康问题，由于生物和社会文化因素，尤其影响妇女。传统医学因其可及性、可负担性和文化接受性而广泛应用于性传播疾病的治疗。然而，由于缺乏严格的科学验证和临床试验，它有一些局限性，挑战其有效性和可靠性。本研究旨在探讨传统医学与现代性病管理方法的结合。本综述的目的是通过比较分析弥合传统医学实践与现代干预措施之间的知识差距。它还旨在解决在获得保健服务方面的差距，特别是在经济限制限制常规对抗疗法的提供的贫困地区。方法采用系统文献复习法，探讨传统医学在性病治疗中的应用。从2024年1月开始，检索了Pub Med、b谷歌scholar、science direct、web of science等数据库。搜索词包括“传统医学”、“性传播疾病”、“药用植物”和特定植物名称（例如：印度楝树、中国、芦荟）。最初共检索了381篇文章，并删除了重复的文章。纳入标准侧重于为性病治疗、文化应用和与现代医学结合提供体外和体内数据的研究。相关提取使用结构数据库，捕获植物种类，活性化合物，作用机制和治疗结果。与世卫组织和国家数据库交叉对照，确保纳入最新的流行和管理情况。研究结果表明，传统药物的实践，包括使用特定植物和整体方法，在性传播疾病的管理和提高整体健康方面提供了宝贵的好处。传统医学与现代保健做法的结合提供了一种全面的方法，不仅处理健康的身体方面，而且处理情感和社会方面。本综述中发现的局限性主要源于纳入的临床试验数量有限。这些研究主要阐明了作用的理论机制和生物学途径。然而，这些结果不能直接外推到人类的临床结果或治疗益处，强调在解释这些发现的过渡潜力时需要谨慎。这篇综述强调了将传统医学方法与现代临床实践相结合的重要性，以创造一种包容和文化敏感的方法来管理性病和女性健康。安全的性行为、定期检查和性病预防教育以及传统医学的重要性被强调为促进整体福祉的综合战略的一部分。
{"title":"Exploring the role of traditional medicine in complementary management for sexually transmitted diseases (STDs)","authors":"Amit Anand , Santhepete Nanjundiah. Manjula , Mruthunjaya Kenganora , Subhajit Mandal , Himanshu Sharma , Rashmi Pathak","doi":"10.1016/j.aimed.2025.100531","DOIUrl":"10.1016/j.aimed.2025.100531","url":null,"abstract":"<div><h3>Background</h3><div>Sexually Transmitted Disease (STDs) remain a significant global health issue, particularly affecting women due to biological and sociocultural factors. Traditional medicine has been widely used in the management of sexually transmitted disease due to its accessibility, affordability and cultural acceptance. However, it has several limitations that challenge its efficacy and reliability due to absence of rigorous scientific validation and clinical trials. The study was undertaken to explore the integration of traditional medicine with modern approaches to STD management. The purpose of the review to bridge the gap in knowledge between traditional medicinal practices and modern interventions through a comparative analysis. It also aims to address the gaps in healthcare access, particularly in underprivileged regions where economic constraints limit the availability of conventional allopathic treatments.</div></div><div><h3>Methods</h3><div>The study employed systematic literature review methodology to explore the application of traditional medicine in STD management. Databases such as Pub Med, Google scholar, science direct, web of science was searched from up to January 2024. Search terms included “traditional medicine, “STDs”, “medicinal plants” and specific plant names (eg: Neem, Echinea, <em>Aloe vera</em>). A total of 381 articles were initially retrieved and duplicates were removed. Inclusion criteria focused on studies providing <em>in-vitro</em> and <em>in-vivo</em> data for STD treatment, cultural applications and integration with modern medicine. Relevant were extracted using a structural database, capturing the plant species, active compounds, mechanisms of action and therapeutic outcomes. Cross referencing with WHO and national databases ensured the inclusion of the latest prevalence and management.</div></div><div><h3>Results</h3><div>The findings suggest practice of traditional medicines including the use of specific plants and holistic approaches offers valuable benefits in the management of STDs and enhancing overall wellbeing. The integration of traditional medicine with modern health practices provides a comprehensive approach that addresses not only the physical aspects of health but also the emotional and social dimension. The limitations of the findings presented in the review primarily stem from the limited number of clinical trials included. Such studies primarily elucidate theoretical mechanisms of action and biological pathways. However, these results cannot be directly extrapolated to clinical outcomes or therapeutic benefits in human populations, highlighting the need for caution when interpreting the transitional potential of these findings.</div></div><div><h3>Discussion</h3><div>The review highlights the importance of combine approach of traditional medicine with modern clinical practices to create an inclusive and culturally sensitive approach to STD management and female health. The signi","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100531"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-26DOI: 10.1016/j.aimed.2025.100535
Hamisi Yunus Nchimbi
Introduction
This study explored the integration of traditional knowledge and contemporary science in the ethnopharmacology of Calotropis procera in the Kongwa District, Dodoma region in Tanzania.
Method
A cross-sectional design combining qualitative interviews with 110 respondents from Lenjulu and Majawanga villages, alongside laboratory analyses, was employed. These included preliminary phytochemical screening, GC–MS complemented by LC-MS, and in vitro antimicrobial assays using the microdilution method in 96-well microtiter plates.
Results
Ethnobotanical data revealed that traditional knowledge of C. procera is predominantly held by older community members, with 41.8 % of respondents above 55 years, and is transmitted mainly through intergenerational transfer, apprenticeships, and gender-specific roles. Phytochemical screening confirmed the presence of key bioactive compounds such as phenols, flavonoids, alkaloids, tannins, saponins, terpenoids, and steroids, validating its traditional use in treating ailments. The chemical profiling of C. procera using LC-MS and GC-MS revealed several dominant bioactive compounds across multiple pharmacological classes. For example, LC-MS analysis identified amino acids L-Tyrosine (12.73 %) and L-Isoleucine (8.92 %) and a flavonoid Quercetin (9.65 %), indicating their abundance and potential biological significance. GC-MS results highlighted a sesquiterpene Caryophyllene (8.12 %), a diterpene Neophytadiene (4.92 %) and a triterpenoid Squalene (3.56 %), all are known for anti-inflammatory and antimicrobial activities. These findings underscore the phytochemical richness and therapeutic potential of C. procera. In vitro antimicrobial assays revealed pronounced antibacterial efficacy of the C. procera, with B.subtilis exhibiting the highest susceptibility (MIC: 7.03 mg/L), followed by S.typhi (MIC: 14.06 mg/L), E.coli (MIC: 28.13 mg/L), and S.aureus (MIC: 56.25 mg/L). The observed activity is attributed to the presence of bioactive phytochemical constituents, underscoring the plant’s ethnopharmacological relevance as a promising source of natural antibacterial compounds.
Conclusion
These findings support the therapeutic potential of C. procera and underscore the critical need to preserve traditional medical knowledge for future healthcare applications.
Take-home message
Preserving the traditional knowledge of C. procera in Kongwa District is essential for future pharmaceutical and medical breakthroughs, as scientific validation has confirmed its strong antibacterial properties.
{"title":"Ethnopharmacology of Calotropis procera: Traditional knowledge and scientific insights from Dodoma Region, Tanzania","authors":"Hamisi Yunus Nchimbi","doi":"10.1016/j.aimed.2025.100535","DOIUrl":"10.1016/j.aimed.2025.100535","url":null,"abstract":"<div><h3>Introduction</h3><div>This study explored the integration of traditional knowledge and contemporary science in the ethnopharmacology of <em>Calotropis procera</em> in the Kongwa District, Dodoma region in Tanzania.</div></div><div><h3>Method</h3><div>A cross-sectional design combining qualitative interviews with 110 respondents from Lenjulu and Majawanga villages, alongside laboratory analyses, was employed. These included preliminary phytochemical screening, GC–MS complemented by LC-MS, and in vitro antimicrobial assays using the microdilution method in 96-well microtiter plates.</div></div><div><h3>Results</h3><div>Ethnobotanical data revealed that traditional knowledge of <em>C. procera</em> is predominantly held by older community members, with 41.8 % of respondents above 55 years, and is transmitted mainly through intergenerational transfer, apprenticeships, and gender-specific roles. Phytochemical screening confirmed the presence of key bioactive compounds such as phenols, flavonoids, alkaloids, tannins, saponins, terpenoids, and steroids, validating its traditional use in treating ailments. The chemical profiling of <em>C. procera</em> using LC-MS and GC-MS revealed several dominant bioactive compounds across multiple pharmacological classes. For example, LC-MS analysis identified amino acids L-Tyrosine (12.73 %) and L-Isoleucine (8.92 %) and a flavonoid Quercetin (9.65 %), indicating their abundance and potential biological significance. GC-MS results highlighted a sesquiterpene Caryophyllene (8.12 %)<strong>,</strong> a diterpene Neophytadiene (4.92 %) and a triterpenoid Squalene (3.56 %), all are known for anti-inflammatory and antimicrobial activities. These findings underscore the phytochemical richness and therapeutic potential of <em>C. procera</em>. In vitro antimicrobial assays revealed pronounced antibacterial efficacy of the <em>C. procera</em>, with B.subtilis exhibiting the highest susceptibility (MIC: 7.03 mg/L), followed by S.typhi (MIC: 14.06 mg/L), E.coli (MIC: 28.13 mg/L), and S.aureus (MIC: 56.25 mg/L). The observed activity is attributed to the presence of bioactive phytochemical constituents, underscoring the plant’s ethnopharmacological relevance as a promising source of natural antibacterial compounds.</div></div><div><h3>Conclusion</h3><div>These findings support the therapeutic potential of <em>C. procera and underscore the critical need to preserve traditional medical knowledge for future healthcare applications.</em></div></div><div><h3>Take-home message</h3><div>Preserving the traditional knowledge of <em>C. procera</em> in Kongwa District is essential for future pharmaceutical and medical breakthroughs, as scientific validation has confirmed its strong antibacterial properties.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100535"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-26DOI: 10.1016/j.aimed.2025.100533
Bhargav Sarma K , Vaishali Vasant Dolas , Vijay Nema
Introduction
Host-directed therapies (HDTs) for tuberculosis are being investigated. By regulating host cell factors, especially in conditions like Drug-resistant tuberculosis, the increasing burden of Anti-Microbial Resistance (AMR) can be reduced. The role of homoeopathic drugs or CAM (complementary and alternative medicine) drugs in regulating host-directed mechanisms is largely unknown. The primary objective of this scoping review is to identify the host-directed mechanisms of homoeopathic drugs in relation to Mycobacterium tuberculosis pathophysiology. The second objective is to understand whether these host-directed mechanisms can be useful for treating sensitive and drug-resistant tuberculosis.
Methods
Our scoping review was drafted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) extension for scoping reviews. The following databases were searched to identify potentially relevant papers: PUBMED, COCHRANE, AYUSH RESEARCH PORTAL, and Google SCHOLAR. Forty-eight papers were screened by two people independently with blinding using Rayyan.
Results
The number of papers identified from databases and registers was 82. Only 15 papers were included in the final selection, while others were excluded because they did not meet the criteria for homoeopathy, host-directed mechanisms, and drug-resistant tuberculosis.
Discussion
To be considered host-directed, a homoeopathic drug action must act through the following mechanisms: regulation of adaptive immune responses, innate immune responses, cell death targets, and metabolism regulation. If we analyse the studies taken for review, we may find that some homoeopathic drugs regulate cytokines, matrix metalloproteinases (MMPs), Phosphofructokinase and other mechanisms. These experiments demonstrate that homoeopathic drugs act through host-directed mechanisms, but there is a lack of research papers on sensitive and drug-resistant tuberculosis.
Conclusion
So this concludes that in this review we were able to achieve only one objective which is the action of homoeopathic drugs through the host-directed mechanism, further research with In Vitro or In Vivo models can help us to complete our second objective.
目前正在研究针对结核病的宿主导向疗法（HDTs）。通过调节宿主细胞因子，特别是在耐药结核病等情况下，可以减少抗微生物药物耐药性（AMR）日益增加的负担。顺势疗法药物或CAM（补充和替代药物）药物在调节宿主导向机制中的作用在很大程度上是未知的。本综述的主要目的是确定与结核分枝杆菌病理生理相关的顺势疗法药物的宿主定向机制。第二个目标是了解这些宿主导向机制是否可用于治疗敏感和耐药结核病。方法采用PRISMA（优选报告项目用于系统评价和荟萃分析）扩展进行范围评价。检索了以下数据库以确定可能相关的论文：PUBMED、COCHRANE、AYUSH RESEARCH PORTAL和谷歌SCHOLAR。48篇论文由两个人独立使用Rayyan进行盲法筛选。结果从数据库和注册库中检索到的论文数量为82篇。最终入选的论文只有15篇，其他论文因不符合顺势疗法、宿主导向机制和耐药结核病的标准而被排除。为了被认为是宿主导向的，顺势疗法药物的作用必须通过以下机制起作用：调节适应性免疫反应、先天免疫反应、细胞死亡靶点和代谢调节。如果我们对已有的研究进行分析，我们可能会发现一些顺势疗法药物调节细胞因子、基质金属蛋白酶（MMPs）、磷酸果糖激酶等机制。这些实验表明，顺势疗法药物通过宿主导向机制起作用，但缺乏关于敏感和耐药结核病的研究论文。综上所述，在本综述中我们只能达到顺势疗法药物通过宿主作用机制的一个目标，进一步的体外或体内模型研究可以帮助我们完成第二个目标。
{"title":"A scoping review exploring the role of homoeopathic drugs as a host directed therapy in the management of drug-resistant tuberculosis","authors":"Bhargav Sarma K , Vaishali Vasant Dolas , Vijay Nema","doi":"10.1016/j.aimed.2025.100533","DOIUrl":"10.1016/j.aimed.2025.100533","url":null,"abstract":"<div><h3>Introduction</h3><div>Host-directed therapies (HDTs) for tuberculosis are being investigated. By regulating host cell factors, especially in conditions like Drug-resistant tuberculosis, the increasing burden of Anti-Microbial Resistance (AMR) can be reduced. The role of homoeopathic drugs or CAM (complementary and alternative medicine) drugs in regulating host-directed mechanisms is largely unknown. The primary objective of this scoping review is to identify the host-directed mechanisms of homoeopathic drugs in relation to Mycobacterium tuberculosis pathophysiology. The second objective is to understand whether these host-directed mechanisms can be useful for treating sensitive and drug-resistant tuberculosis.</div></div><div><h3>Methods</h3><div>Our scoping review was drafted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) extension for scoping reviews. The following databases were searched to identify potentially relevant papers: PUBMED, COCHRANE, AYUSH RESEARCH PORTAL, and Google SCHOLAR. Forty-eight papers were screened by two people independently with blinding using Rayyan.</div></div><div><h3>Results</h3><div>The number of papers identified from databases and registers was 82. Only 15 papers were included in the final selection, while others were excluded because they did not meet the criteria for homoeopathy, host-directed mechanisms, and drug-resistant tuberculosis.</div></div><div><h3>Discussion</h3><div>To be considered host-directed, a homoeopathic drug action must act through the following mechanisms: regulation of adaptive immune responses, innate immune responses, cell death targets, and metabolism regulation. If we analyse the studies taken for review, we may find that some homoeopathic drugs regulate cytokines, matrix metalloproteinases (MMPs), Phosphofructokinase and other mechanisms. These experiments demonstrate that homoeopathic drugs act through host-directed mechanisms, but there is a lack of research papers on sensitive and drug-resistant tuberculosis.</div></div><div><h3>Conclusion</h3><div>So this concludes that in this review we were able to achieve only one objective which is the action of homoeopathic drugs through the host-directed mechanism, further research with In Vitro or In Vivo models can help us to complete our second objective.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100533"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-25DOI: 10.1016/j.aimed.2025.100532
Javier Fernández-Sánchez , Daniel Trujillo-Colmena , Daniel Collado-Mateo , Juan Luis Leon-Llamas , Ana Myriam Lavín-Pérez , Miriam Lorenzo-González
Art therapies have emerged as a cost-effective global resource for promoting wellbeing, and quality of life and for reducing mental health problems through mind-body connection and creative expression. The aim was to systematically review the current evidence about the benefits of dance and theater-based interventions on the life satisfaction of participants. Furthermore, this study is aimed to synthesize and meta-analyze the results of the previously published randomized controlled trials. Thus, to identify the articles, a systematic search was conducted in PubMed (Medline) and Web of Science. The inclusion criteria included: being a randomized controlled trial, evaluating the effects of dance or drama interventions and providing pre-post data showing the effects on life satisfaction. A total of 12 articles were included in the Systematic Review, with 8 of them being included in the meta-analysis. Meta-analysis results showed that dance and drama interventions are effective (p = 0.01) in increasing the satisfaction with life of participants with different ages and conditions. In conclusion, dance and theater-based interventions are two forms of art therapies that may be useful to enhance the life satisfaction of people. Furthermore, further studies are needed to make stronger evidence-based recommendations or comparisons to other types of physical activity.
艺术疗法已经成为一种具有成本效益的全球资源，通过身心联系和创造性表达来促进健康和生活质量，并减少心理健康问题。目的是系统地回顾当前的证据，证明舞蹈和戏剧干预对参与者生活满意度的好处。此外，本研究旨在综合和荟萃分析之前发表的随机对照试验的结果。因此，为了识别这些文章，我们在PubMed （Medline）和Web of Science中进行了系统的搜索。纳入标准包括：随机对照试验，评估舞蹈或戏剧干预的效果，并提供显示对生活满意度影响的前后数据。系统评价共纳入12篇文章，其中8篇纳入meta分析。meta分析结果显示，舞蹈和戏剧干预在提高不同年龄和条件的参与者的生活满意度方面是有效的（p = 0.01）。总之，舞蹈和戏剧干预是两种形式的艺术疗法，可能有助于提高人们的生活满意度。此外，需要进一步的研究来提出更有力的基于证据的建议或与其他类型的身体活动进行比较。
{"title":"Effects of art therapy interventions on satisfaction with life: A systematic review and meta-analysis","authors":"Javier Fernández-Sánchez , Daniel Trujillo-Colmena , Daniel Collado-Mateo , Juan Luis Leon-Llamas , Ana Myriam Lavín-Pérez , Miriam Lorenzo-González","doi":"10.1016/j.aimed.2025.100532","DOIUrl":"10.1016/j.aimed.2025.100532","url":null,"abstract":"<div><div>Art therapies have emerged as a cost-effective global resource for promoting wellbeing, and quality of life and for reducing mental health problems through mind-body connection and creative expression. The aim was to systematically review the current evidence about the benefits of dance and theater-based interventions on the life satisfaction of participants. Furthermore, this study is aimed to synthesize and meta-analyze the results of the previously published randomized controlled trials. Thus, to identify the articles, a systematic search was conducted in PubMed (Medline) and Web of Science. The inclusion criteria included: being a randomized controlled trial, evaluating the effects of dance or drama interventions and providing pre-post data showing the effects on life satisfaction. A total of 12 articles were included in the Systematic Review, with 8 of them being included in the meta-analysis. Meta-analysis results showed that dance and drama interventions are effective (p = 0.01) in increasing the satisfaction with life of participants with different ages and conditions. In conclusion, dance and theater-based interventions are two forms of art therapies that may be useful to enhance the life satisfaction of people. Furthermore, further studies are needed to make stronger evidence-based recommendations or comparisons to other types of physical activity.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100532"},"PeriodicalIF":1.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-24DOI: 10.1016/j.aimed.2025.100534
Zeliha Buyukbayram Genc , Seyhan Citlik Saritas
Background
Hypertension is one of the most common cardiovascular diseases.
Purpose
This study was conducted to examine the attitudes of patients diagnosed with hypertension toward holistic complementary and alternative medicine.
Method
This descriptive and cross-sectional study was carried out with 230 adult patients diagnosed with hypertension who applied to the internal medicine and cardiology outpatient clinics of a Training and Research Hospital. Data were collected using the Personal Information Form and the Attitude Scale towards Holistic Complementary and Alternative Medicine. Data were analyzed with descriptive statistics, independent groups t-test, Kruskal-Wallis, and ANOVA tests. In addition, the Dunn-Bonferroni test was used to determine the difference between groups.
Results
The study revealed that the mean age of the patients was 54.36 ± 13.09, while 59.1 % were women, 81.3 % were married, 27.4 % were literate, and 61.3 % were unemployed. Also, it was observed that 41.3 % of the patients were diagnosed with hypertension between 1 and 5 years, 58.7 % had no other chronic illnesses, and 60.0 % had a family hypertension history. Additionally, 77.0 % of the patients used CAM, 24.9 % got information from the Internet/media via CAM, 27.1 % used CAM in addition to medical treatment, 56.5 % found CAM methods safe, 38.4 % used herbal agents, 76.3 % It has been determined that ten of them benefit from the use of CAM. The patients’ total mean score participating in the study in HCAMQ was 28.80 ± 6.73.
Conclusion
It was determined that the patients' attitudes toward CAM were positive and moderate. Additionally, the findings disclosed that the education level of the patients affected their use of CAM, their benefit from CAM, and their attitudes towards CAM.
{"title":"Investigation of attitudes of hypertension patients toward holistic complementary and alternative medicine","authors":"Zeliha Buyukbayram Genc , Seyhan Citlik Saritas","doi":"10.1016/j.aimed.2025.100534","DOIUrl":"10.1016/j.aimed.2025.100534","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is one of the most common cardiovascular diseases.</div></div><div><h3>Purpose</h3><div>This study was conducted to examine the attitudes of patients diagnosed with hypertension toward holistic complementary and alternative medicine.</div></div><div><h3>Method</h3><div>This descriptive and cross-sectional study was carried out with 230 adult patients diagnosed with hypertension who applied to the internal medicine and cardiology outpatient clinics of a Training and Research Hospital. Data were collected using the Personal Information Form and the Attitude Scale towards Holistic Complementary and Alternative Medicine. Data were analyzed with descriptive statistics, independent groups t-test, Kruskal-Wallis, and ANOVA tests. In addition, the Dunn-Bonferroni test was used to determine the difference between groups.</div></div><div><h3>Results</h3><div>The study revealed that the mean age of the patients was 54.36 ± 13.09, while 59.1 % were women, 81.3 % were married, 27.4 % were literate, and 61.3 % were unemployed. Also, it was observed that 41.3 % of the patients were diagnosed with hypertension between 1 and 5 years, 58.7 % had no other chronic illnesses, and 60.0 % had a family hypertension history. Additionally, 77.0 % of the patients used CAM, 24.9 % got information from the Internet/media via CAM, 27.1 % used CAM in addition to medical treatment, 56.5 % found CAM methods safe, 38.4 % used herbal agents, 76.3 % It has been determined that ten of them benefit from the use of CAM. The patients’ total mean score participating in the study in HCAMQ was 28.80 ± 6.73.</div></div><div><h3>Conclusion</h3><div>It was determined that the patients' attitudes toward CAM were positive and moderate. Additionally, the findings disclosed that the education level of the patients affected their use of CAM, their benefit from CAM, and their attitudes towards CAM.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100534"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-24DOI: 10.1016/j.aimed.2025.100529
Hrishikesh Khude , Pravin Shende
Artificial Intelligence (AI) analyzes complex medical data records using Machine learning (ML), Natural Language Processing (NLP), and Deep Learning (DL) algorithms. These algorithms assist physicians in the optimization of therapeutic decisions that allow for the integration and interpretation of individual biological data, including genomics, proteomics, and transcriptomics. By identifying complex patterns in these data records, AI-driven systems facilitate the development of personalized treatment strategies that align with individual patient profiles. Furthermore, AI enhances pharmacovigilance by predicting potential drug interactions and conducting in-silico toxicity risk assessments through advanced molecular composition analysis. Moreover, AI accelerates the drug discovery process by screening and identifying novel drugs, thereby facilitating the development of targeted treatment. AI empowers physicians to prescribe medications, perform real-time formulary checks, and recommend therapeutic equivalent, economically viable alternatives to patient-specific factors. AI-driven clinical decision support systems (CDSS) further assist physicians in improving drug compliance and optimizing population health strategies by identifying pharmacologically cost-effective therapies. Additionally, AI enhances real-time clinical decision-making by improving diagnostic precision, refining therapeutic choices, and patient outcomes. The evolution of AI technologies offers immense potential for seamless integration into healthcare systems despite challenges such as data bias, limited model interpretability, and regulatory complexities. This integration revolutionizes personalized medicines, accelerates the drug discovery process, and improves the safety, efficacy, and cost-effectiveness of drug therapy. In summary, AI plays a significant role in modern medicine, promoting data-based clinical decisions and enhancing the overall quality and efficiency of healthcare delivery.
{"title":"AI-driven clinical decision support systems: Revolutionizing medication selection and personalized drug therapy","authors":"Hrishikesh Khude , Pravin Shende","doi":"10.1016/j.aimed.2025.100529","DOIUrl":"10.1016/j.aimed.2025.100529","url":null,"abstract":"<div><div>Artificial Intelligence (AI) analyzes complex medical data records using Machine learning (ML), Natural Language Processing (NLP), and Deep Learning (DL) algorithms. These algorithms assist physicians in the optimization of therapeutic decisions that allow for the integration and interpretation of individual biological data, including genomics, proteomics, and transcriptomics. By identifying complex patterns in these data records, AI-driven systems facilitate the development of personalized treatment strategies that align with individual patient profiles. Furthermore, AI enhances pharmacovigilance by predicting potential drug interactions and conducting in-silico toxicity risk assessments through advanced molecular composition analysis. Moreover, AI accelerates the drug discovery process by screening and identifying novel drugs, thereby facilitating the development of targeted treatment. AI empowers physicians to prescribe medications, perform real-time formulary checks, and recommend therapeutic equivalent, economically viable alternatives to patient-specific factors. AI-driven clinical decision support systems (CDSS) further assist physicians in improving drug compliance and optimizing population health strategies by identifying pharmacologically cost-effective therapies. Additionally, AI enhances real-time clinical decision-making by improving diagnostic precision, refining therapeutic choices, and patient outcomes. The evolution of AI technologies offers immense potential for seamless integration into healthcare systems despite challenges such as data bias, limited model interpretability, and regulatory complexities. This integration revolutionizes personalized medicines, accelerates the drug discovery process, and improves the safety, efficacy, and cost-effectiveness of drug therapy. In summary, AI plays a significant role in modern medicine, promoting data-based clinical decisions and enhancing the overall quality and efficiency of healthcare delivery.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100529"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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