Advances in integrative medicine最新文献_第4页

Safety and efficacy of colchicine in Covid-19 treatment: Systematic review and meta-analysis 秋水仙碱治疗Covid-19的安全性和有效性：系统评价和荟萃分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-10 DOI: 10.1016/j.aimed.2025.100571

Ahmed Hosney Nada , Ismail A. Ibrahim , Nada Khalid Asar , Abdulrahman Qenawy , Mariam M. Mohammed , Mohamed Wagdy , Heidi Sherif Farouk

Background

Colchicine is an anti-inflammatory drug used for the treatment of gout and other autoinflammatory conditions. Several trials reported promising results of the efficacy of colchicine in Covid-19 due to its anti-inflammatory properties. However, applying these results to clinical settings remains the subject of ongoing research.

Methods

We performed a systematic review and meta-analysis on the efficacy and safety of colchicine in the treatment of Covid-19. PubMed, Cochrane Library, Web of Science, and Scopus were searched for relevant studies. The primary outcomes were 28-day mortality, invasive mechanical ventilation, non-invasive mechanical ventilation, and ICU admissions. The risk ratio was used to compare effectiveness between the two groups. Subgroup analysis was done for C-reactive protein and duration of hospitalization.

Results

17 randomized controlled trials with a total of 25478 patients were included. The overall Risk ratio didn’t favor any of the two groups in terms of 28-day mortality (RR = 1.03, 95 % CI [0.93:1.15], P = 0.58), non-invasive mechanical ventilation (RR = 0.81, 95 % CI [0.44:1.48], P = 0.49), ICU admission (RR = 0.89, 95 % CI [0.56:1.41], P = 0.62).

The overall mean difference (MD) did not show statistical significance between both groups in terms of C- reactive protein (CRP) (mg/dl) (MD = −1.21, 95 % CI [-2.42:0.01], P = 0.05), lactate dehydrogenase (LDH) (U/L) (MD = 50.95, 95 % CI [-92.07: 193.98], Ferritin (ng/ml) (MD = 128.08, 95 % CI [51.97:204.18], P = 0.001), ICU length of stay (MD = −0.09, 95 % CI [-0.34:0.15], P = 0.45) and duration of hospitalization (MD = −0.41, 95 % CI [-1.56:0.73], P = 0.48).

Conclusion

In Covid-19 treatment, colchicine didn’t result in significant benefits in terms of clinical outcomes. More large-scale randomized clinical trials with standardized dosages and long-term follow-up are needed for further investigation into the colchicine effect.

背景：秋水仙碱是一种抗炎药物，用于治疗痛风和其他自身炎症。由于秋水仙碱的抗炎特性，一些试验报告了秋水仙碱对Covid-19的疗效有希望的结果。然而，将这些结果应用于临床环境仍然是正在进行的研究的主题。方法对秋水仙碱治疗新冠肺炎的疗效和安全性进行系统评价和meta分析。检索PubMed、Cochrane Library、Web of Science和Scopus等相关研究。主要结局为28天死亡率、有创机械通气、无创机械通气和ICU入院情况。风险比用于比较两组间的疗效。对c反应蛋白和住院时间进行亚组分析。结果纳入17项随机对照试验，共纳入25478例患者。整体的风险比不支持任何两组28天的死亡率(RR = 1.03, 95 % CI [0.93:1.15], P = 0.58),非侵入性机械通气(RR = 0.81, 95 % CI [0.44:1.48], P = 0.49),入住ICU (RR = 0.89, 95 % CI [0.56:1.41], P = 0.62)。总体平均差(MD)两组之间没有统计学意义的C -反应蛋白(CRP) (mg / dl) (MD =−1.21,95 % CI [-2.42:0.01], P = 0.05),乳酸脱氢酶(LDH) (U / L) (MD = 50.95, 95 % CI(-92.07: 193.98),铁蛋白(ng / ml) (MD = 128.08, 95 % CI [51.97:204.18], P = 0.001),ICU滞留时间(MD =−0.09,95 % CI [-0.34:0.15], P = 0.45),住院时间(MD =−0.41,95 % CI [-1.56:0.73], P = 0.48)。结论秋水仙碱在新冠肺炎治疗中的临床效果不明显。为了进一步研究秋水仙碱的作用，需要更多标准化剂量的大规模随机临床试验和长期随访。

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引用次数: 0

Dynamics of traditional healthcare knowledge transmission and practice in rural nigeria: A case study of Egbejila community 尼日利亚农村传统保健知识传播和实践的动态：以Egbejila社区为例

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-10 DOI: 10.1016/j.aimed.2025.100578

Ahmed Ahmed Olaitan , Asmawi Ibrahim , Mohd Syaiful Nizam Bin Abu Hassan

This research study examines the dynamics of traditional healthcare knowledge transmission and practice in Egbejila, a rural community in Nigeria. Traditional healthcare knowledge is deeply embedded in cultural heritage and remains essential for sustaining traditional healthcare practices across generations. Through a qualitative research approach, the collection of primary data involved interviews and focus group discussions. Besides, secondary sources were gathered to complement the primary data. The study comprised twenty-five (25) informants. The collected data were analysed using a qualitative data analysis software package known as NVivo. Findings from the study revealed that traditional practitioners in the Egbejila community established that they acquired their traditional healthcare knowledge from various sources, which significantly contributed to their specialization. The findings also shed light on the participants' knowledge regarding the aetiology of illness, common illnesses, and diagnostic methods employed by traditional healthcare practitioners in the study community. Based on the findings, it is recommended that there is a need for better healthcare knowledge acquisition; the government should establish a modality for formal sandwich training or a traditional healthcare institute that accommodates formal teaching and advanced apprenticeship, drawing inspiration from other countries.

本研究考察了尼日利亚农村社区Egbejila传统卫生保健知识传播和实践的动态。传统医疗保健知识深深植根于文化遗产中，对于几代人维持传统医疗保健实践仍然至关重要。通过定性研究方法，主要数据的收集涉及访谈和焦点小组讨论。此外，还收集了二手资料来补充原始数据。这项研究包括25名被调查者。使用定性数据分析软件包NVivo对收集的数据进行分析。研究结果表明，Egbejila社区的传统从业人员证实，他们从各种来源获得传统保健知识，这对他们的专业化有很大贡献。研究结果还揭示了参与者对疾病的病因、常见疾病和研究社区中传统医疗从业人员使用的诊断方法的了解。根据研究结果，建议有必要更好地获取医疗保健知识；政府应借鉴其他国家的经验，建立一种正规的三明治式培训模式，或建立一所兼有正规教学和高级学徒的传统医疗机构。

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引用次数: 0

Prolotherapy for the treatment of sacroiliac joint instability in patients with Ehlers-Danlos syndrome 前驱疗法治疗ehers - danlos综合征患者骶髂关节不稳

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-10 DOI: 10.1016/j.aimed.2025.100577

Philip Montana , Hung M. Le , Jeffrey Lo , Olivia Elie , Danielle L. Cook , Sealy Hambright , Pierre d’Hemecourt

Aim

To evaluate patient response and efficacy of prolotherapy in managing sacroiliac joint (SIJ) instability and pain in patients with Ehlers-Danlos syndrome (EDS).

Methods

A retrospective cohort study on patients aged 13–55 years diagnosed with EDS who received prolotherapy for SIJ instability. Patient demographics, treatment characteristics, and clinical outcomes were assessed by phone follow-up. The visual analog scale (VAS) and Oswestry Low Back Disability (ODI) were utilized to measure pain and disability respectively pre- and post-intervention. Spearman correlation was used to determine correlations between injection number and VAS/ODI scores.

Results

Ten patients were included (median age 32 years). 60 % (6/10) had Polidocanol, 30 % (3/10) had sodium tetradecyl sulfate, and one person (10 %) had PRP. The median number of injections was 2 (range, 1–3). Median follow-up was 9 months (IQR, 6–11) after their injection(s). Median VAS score at follow-up was 2 (IQR, 0–4, p = 0.008). There was no significant correlation between the number of injections and VAS (r = 0.29; p = 0.42) or ODI scores (r = 0.21; p = 0.56). Median ODI score was 13 (IQR, 0–24) and 70 % (7/10) of the cohort resided in the “minimal disability” group. Compared to before treatment, 90 % reported moderate to significant improvement in exercise ability and activities of daily living while 100 % showed moderate to significant improvement in movement apprehension.

Conclusions

Prolotherapy may be a promising treatment option for SIJ instability in patients with EDS. It significantly reduced pain and improved functional outcomes. Further prospective studies with larger sample sizes are needed to confirm these findings and to optimize treatment protocols.

目的评价前驱疗法治疗ehers - danlos综合征（EDS）患者骶髂关节（SIJ）不稳定及疼痛的疗效和反应。方法回顾性队列研究13-55岁诊断为EDS并接受前驱治疗的SIJ不稳定患者。通过电话随访评估患者人口统计学、治疗特征和临床结果。采用视觉模拟量表（VAS）和Oswestry腰背功能障碍量表（ODI）分别测量干预前和干预后的疼痛和功能障碍。采用Spearman相关法确定注射次数与VAS/ODI评分的相关性。结果纳入患者10例（中位年龄32岁）。聚多醇60 %(6/10)，硫酸十四烷基钠30 % (3/10)，PRP 1人（10 %）。注射次数中位数为2次（范围1-3）。注射后中位随访时间为9个月（IQR, 6-11）。随访时VAS评分中位数为2 （IQR, 0-4, p = 0.008）。注射次数与VAS （r = 0.29;p = 0.42）或ODI评分（r = 0.21;p = 0.56）无显著相关性。ODI得分中位数为13 (IQR, 0-24), 70% %（7/10）的队列处于“轻度残疾”组。与治疗前相比，90% %的患者报告在运动能力和日常生活活动方面有中度到显著的改善，而100% %的患者在运动恐惧方面有中度到显著的改善。结论前驱治疗可能是治疗EDS患者SIJ不稳定的一种有希望的治疗方法。它显著减轻了疼痛并改善了功能预后。需要进一步的更大样本量的前瞻性研究来证实这些发现并优化治疗方案。

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引用次数: 0

Arnebia euchroma root ointment for post-hemorrhoidectomy wound care: A randomized controlled trial 紫草软膏用于痔疮切除术后伤口护理：一项随机对照试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-10 DOI: 10.1016/j.aimed.2025.100576

Ehsan Memarbashi , Ebrahim Nasiri-Formi , Mohammad Etezadpour , Seyed Jalal Hosseinimehr

Introduction

Hemorrhoidectomy is a common surgical procedure for hemorrhoids, but postoperative complications can significantly affect recovery quality. This study investigates the effect of Arnebia euchroma root ointment on wound healing and related complications in patients undergoing hemorrhoidectomy.

Methods

In this randomized controlled trial, patients who underwent hemorrhoidectomy were assigned to receive either Arnebia euchroma root ointment or a placebo. The primary outcomes measured included the rate of wound healing and the incidence of postoperative complications, such as fear of defecation, over a specified follow-up period.

Results

The application of Arnebia euchroma root ointment demonstrated a significant improvement in wound healing compared to the placebo group. Additionally, the incidence of complications such as pain, bleeding, and infection was notably lower in the treatment group. The mean score of fear of defecation in the control group was 6.86 ± 2.1, and the intervention group was 4.67 ± 1.4.( P < 0.001). Wound healing in the intervention group was better than in the control group, with a relative risk (RR) of 1.40.( P < 0.001).

Conclusion

Arnebia euchroma root ointment may be an effective adjunctive treatment for enhancing wound healing and reducing complications following Hemorrhoidectomy. The positive effects of this ointment are likely attributed to its antibacterial and anti-inflammatory properties, as well as its ability to enhance blood supply to the surgical area.

Take-home massage

The use of Arnebia euchroma root ointment in post-hemorrhoidectomy wound care has demonstrated significant improvement in wound healing and reduction of postoperative complications. This ointment effectively reduces pain, bleeding, and infection, serving as a valuable adjunctive treatment for enhancing wound recovery and decreasing the fear of defecation. Its antibacterial and anti-inflammatory properties, along with improved blood supply to the surgical site, are key factors contributing to its efficacy. These findings suggest that Arnebia euchroma root ointment is a promising option for improving outcomes following hemorrhoidectomy.

摘要痔切除术是治疗痔疮的常用手术方法，但术后并发症严重影响恢复质量。本研究探讨紫草软膏对痔疮切除术患者创面愈合及相关并发症的影响。方法：在这项随机对照试验中，接受痔疮切除术的患者被分配接受紫草软膏或安慰剂。测量的主要结果包括伤口愈合率和术后并发症的发生率，如害怕排便，在指定的随访期间。结果与安慰剂组相比，应用紫草软膏对伤口愈合有显著改善。此外，治疗组疼痛、出血、感染等并发症的发生率明显降低。对照组怕便平均得分为6.86 ± 2.1，干预组平均得分为4.67 ± 1.4。(P & lt; 0.001)。干预组创面愈合优于对照组，相对危险度（RR）为1.40。(P & lt; 0.001)。结论紫草软膏是一种促进痔切除术后创面愈合和减少并发症的有效辅助治疗方法。这种软膏的积极作用可能归功于它的抗菌和抗炎特性，以及它增强手术区域血液供应的能力。带回家按摩在痔疮切除术后伤口护理中使用紫草软膏在伤口愈合和减少术后并发症方面表现出显著的改善。这种软膏有效地减少疼痛、出血和感染，作为一种有价值的辅助治疗，促进伤口恢复和减少排便的恐惧。它的抗菌和抗炎特性，以及改善手术部位的血液供应，是促进其疗效的关键因素。这些研究结果表明，赤藓根软膏是改善痔疮切除术后预后的有希望的选择。

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引用次数: 0

Complementary and alternative medicine use among pediatric cancer patients: A cross-sectional study from a large healthcare system in Saudi Arabia 补充和替代药物在儿童癌症患者中的使用：来自沙特阿拉伯大型医疗保健系统的横断面研究

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-10 DOI: 10.1016/j.aimed.2025.100575

Mohammad Alkaiyat , Reem Al Sudairy , Reem Abdel Lateef , Abdul Rahman Jazieh

Complementary and alternative medicine (CAM) is commonly used among patients with cancer, with most studies focusing on its use in adults. However, only a few studies have specifically focused on pediatric patients with cancer, with no studies reported in the Gulf area. This study investigated the prevalence and pattern of CAM use among pediatric patients with cancer in Saudi Arabia. In this descriptive cross-sectional study, a validated questionnaire was used to collect data from 211 caregivers of pediatric patients with cancer who received care at the pediatric oncology department at King Abdulaziz Medical City. The prevalence of CAM use was 90 % (95 % CI = 85 %–93 %). The most prominent category of CAM used was alternative (nondietary) treatment (184; 87.2 %), which included reading the Quran (165; 86.8 %) and use of olive oil as a lotion (91; 47.6 %). In contrast, complementary (dietary) treatment was less prevalent (60; 28.4 %). The most common complementary treatments were drinking Zamzam water (59; 31.1 %) and consuming honey (37; 19.5 %). Among the caregivers who used CAM for their children and reported improvements, most of them (49; 81 %) attributed this improvement to CAM and standard medical treatment, whereas only six (5.2 %) attributed it to CAM alone. A few number of children received risky CAM products (camel urine with milk, traditional cautery). Most caregivers did not discuss the use of CAM with their children’s oncologists. CAM use was prevalent among pediatric patients with cancer, with no significant associations with demographic or disease characteristics.

补充和替代医学（CAM）通常用于癌症患者，大多数研究集中在成人中使用。然而，只有少数研究专门针对患有癌症的儿科患者，在海湾地区没有研究报告。本研究调查了沙特阿拉伯儿童癌症患者中CAM的患病率和使用模式。在这项描述性横断面研究中，采用一份有效的问卷收集了211名在阿卜杜勒阿齐兹国王医疗城儿科肿瘤科接受治疗的儿科癌症患者的护理人员的数据。CAM的使用率为90 %（95 % CI = 85 % -93 %）。使用的最突出的CAM类别是替代（非饮食）治疗（184;87.2 %），其中包括阅读古兰经（165;86.8 %）和使用橄榄油作为洗剂（91;47.6 %）。相比之下，补充（膳食）治疗较少流行（60;28.4 %）。最常见的补充治疗是饮用Zamzam水（59%;31.1% %）和食用蜂蜜（37%;19.5% %）。在为孩子使用CAM并报告有所改善的护理人员中，大多数人（49;81 %）将这种改善归功于CAM和标准医疗，而只有6人（5.2 %）将其归功于单独的CAM。少数儿童接受了危险的CAM产品（骆驼尿加奶、传统烧灼）。大多数护理人员没有与他们孩子的肿瘤学家讨论CAM的使用。儿童癌症患者普遍使用辅助治疗，与人口统计学或疾病特征无显著关联。

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引用次数: 0

Managing iron overload through dietary modification: A case report 通过饮食调整控制铁超载：一例报告

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-09-02 DOI: 10.1016/j.aimed.2025.100570

Alireza Asghari, Babak Daneshfard, Maryam Golzar

Iron homeostasis is crucial for maintaining optimal health, as both iron deficiency and iron overload can result in significant clinical complications. This case report explores the therapeutic potential of dietary modification in managing iron overload through an individualized, temperament-based nutritional approach. A 35-year-old female presented with symptoms of hair loss and increased blood viscosity, with laboratory findings indicating elevated serum iron levels (48.7 µmol/L) and a high transferrin saturation (0.85). A tailored dietary intervention was initiated, focusing on reducing the intake of warming, desiccating foods and incorporating more hydrating and moistening dietary elements, including increased fluid intake and specific herbal teas. After one month, follow-up assessments revealed normalized serum iron levels (22.3 µmol/L), improved hemorheological parameters, and notable improvement in hair shedding, which coincided with the dietary changes. This case underscores the potential of personalized dietary strategies, grounded in traditional concepts of food temperament, as a non-pharmacological approach to correcting metabolic imbalances associated with iron overload. Future studies are recommended to investigate the efficacy of these dietary strategies.

铁体内平衡对维持最佳健康至关重要，因为铁缺乏和铁超载都可能导致显著的临床并发症。本病例报告探讨了饮食调整的治疗潜力，通过个性化的、基于气质的营养方法来管理铁超载。一名35岁女性出现脱发和血液黏度增加的症状，实验室结果显示血清铁水平升高（48.7 µmol/L）和高转铁蛋白饱和度（0.85）。一项量身定制的饮食干预措施开始实施，重点是减少温暖、干燥食物的摄入，并加入更多的补水和保湿饮食元素，包括增加液体摄入量和特定的草药茶。一个月后，随访评估显示血清铁水平正常化（22.3 µmol/L），血液流变学参数改善，脱发明显改善，这与饮食改变相吻合。这个案例强调了基于传统食物气质概念的个性化饮食策略的潜力，作为一种非药物方法来纠正与铁过载相关的代谢失衡。未来的研究建议调查这些饮食策略的功效。

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引用次数: 0

An analysis of predictors of conventional and complementary healthcare use in Yorkshire 在约克郡的传统和补充保健使用的预测因素分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-08-26 DOI: 10.1016/j.aimed.2025.100566

Felicity Astin , Elizabeth Goyder , Richard Cooper , John Stephenson , Farideh A. Javid

Background

Well-recognised trends in types of services used by patients exist within health service utilisation. One increasing area is complementary and alternative medicine (CAM); considered distinct from the use of health professionals working in conventional medicine. Little is known about the contribution of CAM and whether people using CAM with multiple comorbidities make correspondingly less use of conventional health services.

Aims

1) To describe self-reported visits to conventional health professionals and CAM practitioners, and to identify predictors of such visits; 2) To quantify the effect of demographic, health-related and CAM service take-up factors on contact with health services delivered by conventional health professionals.

Methods

Data from 70,836 participants in the Yorkshire Health Study, a large-scale population-based cohort study, was analysed descriptively and inferentially to test for associations between variables.

Results

3.5 % of the cohort reported accessing CAM services in the previous three months. Level of contact with conventional health professionals was higher in those accessing practitioner-led CAM services (incidence rate ratio [IRR]=1.28; p < 0.001.) Female gender, older age and increased incidence of mental and physical health conditions were also positively associated with the outcome.

Conclusions

Self-reported utilisation of CAM services was low but there were several predictors of recent CAM use based on demographic and health conditions which may be of help in understanding conventional and CAM healthcare utilisation.

背景：在卫生服务利用方面，患者使用的服务类型存在公认的趋势。一个日益增长的领域是补充和替代医学（CAM）；被认为不同于使用从事传统医学工作的卫生专业人员。人们对辅助生殖疗法的作用知之甚少，也不清楚患有多种合并症的辅助生殖疗法患者是否相应减少了对传统卫生服务的使用。目的1)描述自我报告的常规卫生专业人员和辅助医学从业人员的就诊情况，并确定此类就诊的预测因素；2)量化人口统计学、健康相关和辅助医学服务接受因素对接触传统卫生专业人员提供的卫生服务的影响。方法对约克郡健康研究70,836名参与者的数据进行描述性和推断性分析，以检验变量之间的相关性。结果3.5 %的队列报告在过去三个月内使用CAM服务。在接受医生主导的CAM服务的人群中，与传统卫生专业人员接触的水平较高（发病率比[IRR]=1.28; p <； 0.001）。女性性别、年龄较大以及精神和身体健康状况发生率增加也与结果呈正相关。结论自我报告的CAM服务利用率较低，但基于人口统计学和健康状况的近期CAM使用的几个预测指标可能有助于了解常规和CAM医疗保健的利用情况。

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引用次数: 0

A new era in global health: It’s time to act on the promise of integrative medicine 全球卫生的新时代：现在是实现中西医结合承诺的时候了

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-08-25 DOI: 10.1016/j.aimed.2025.100569

Susan Arentz

引用次数: 0

Development and validation of a yoga program for patients with hirayama disease, and feasibility testing through a case series 针对平山病患者的瑜伽项目的开发和验证，以及通过一系列病例的可行性测试

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-08-23 DOI: 10.1016/j.aimed.2025.100563

Vinod Kumar , Nishitha Jasti , Nupur Pruthi , Pooja More , Karthik Mallina , Kankan Gulati , Hemant Bhargav , Shivarama Varambally , Atchayaram Nalini

Background

Hirayama Disease (HD), a rare flexion-induced myelopathy, is typically managed with cervical collar therapy, surgery, and lifestyle modifications. Yoga-based interventions have shown promise in managing neurological disorders such as multiple sclerosis and cervical radiculopathy. Given the pathophysiology of HD, we hypothesized yoga could benefit HD patients, especially those awaiting surgery or contraindicated for it. However, literature search revealed that no standardized yoga protocol for HD currently exists.

Objectives

This study aimed to develop and validate a yoga module for HD and test its feasibility in patients.

Methods

A tailored yoga program was developed by two yoga therapy experts and a neurosurgery consultant. The module was validated by 10 yoga experts and 5 neurologists/neurosurgeons. It was implemented in 20 HD patients to evaluate safety and feasibility. Outcomes included the Visual Analog Scale (VAS) for pain, Client Satisfaction Questionnaire (CSQ-8), hand grip strength (via dynamometer), and a Yoga Performance Assessment (YPA) scale, measured at baseline and after 3 months of practice.

Results

A specific yoga module was finalized for HD patients, designed for those awaiting surgery, unwilling to undergo it, or in the static phase of the disease. The program was found safe and feasible in both online and offline formats. Participants learned and independently practiced the module after 20 supervised sessions and reported a high level of satisfaction. Significant improvements were observed at 3 months in hand grip strength, tremors, and hand fatigue.

Conclusion

The validated yoga module offers a complementary approach to HD management, benefiting patients awaiting or unable to undergo surgery. The findings suggest yoga can address both functional and symptomatic aspects of the disease, providing a safe and effective intervention.

hirayama病（HD）是一种罕见的屈曲性脊髓病，通常通过颈套治疗、手术和生活方式改变来治疗。瑜伽为基础的干预已显示出在管理神经系统疾病，如多发性硬化症和颈椎病的希望。考虑到HD的病理生理学，我们假设瑜伽可以使HD患者受益，特别是那些等待手术或有手术禁忌的患者。然而，文献检索显示，目前尚无针对HD的标准化瑜伽方案。本研究旨在开发和验证针对HD的瑜伽模块，并测试其在患者中的可行性。方法由两名瑜伽治疗专家和一名神经外科顾问制定了量身定制的瑜伽课程。该模块由10名瑜伽专家和5名神经学家/神经外科医生验证。该方法在20例HD患者中实施，以评估其安全性和可行性。结果包括疼痛的视觉模拟量表（VAS）、客户满意度问卷（CSQ-8）、手部握力（通过测力仪）和瑜伽表现评估（YPA）量表，分别在基线和练习3个月后测量。结果为HD患者设计了一个特定的瑜伽模块，该模块专为等待手术、不愿接受手术或处于疾病静态阶段的患者设计。该方案被认为是安全可行的在线和离线格式。参与者在20次有监督的课程后学习并独立练习了该模块，并报告了很高的满意度。3个月时观察到手部握力、震颤和手部疲劳的显著改善。经过验证的瑜伽模块为HD治疗提供了一种补充方法，使等待或无法接受手术的患者受益。研究结果表明，瑜伽可以解决这种疾病的功能和症状方面，提供了一种安全有效的干预措施。

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引用次数: 0

Therapeutic efficacy and safety of Polypodium vulgare L. in psychosomatic and behavioural symptoms and health-related quality of life in premenstrual women: A randomized placebo-controlled study 紫参对经前妇女心身、行为症状和健康相关生活质量的疗效和安全性：一项随机安慰剂对照研究

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2025-08-22 DOI: 10.1016/j.aimed.2025.100560

Marhaba Khanam , Arshiya Sultana , Taseen Banu

Background and objectives

Premenstrual syndrome (PMS) significantly affects the quality of life and disrupts personal and social relationships among women of reproductive age. This study aimed to evaluate the efficacy and safety of Polypodium vulgare L. (Bisfayej) in alleviating PMS symptoms and improving health-related quality of life (HRQoL) in affected women.

Methods

Sixty women diagnosed with PMS were randomly assigned to receive either two capsules of P. vulgare (1000 mg) or a placebo. The treatment was administered twice daily for three menstrual cycles, starting from day 16 of the cycle until day 5 of the following cycle. The primary outcomes were changes in symptom severity, measured by the Premenstrual Syndrome Scale (PMSS), and symptom duration, recorded using a premenstrual tracker sheet. The secondary outcome was assessed using the EQ-5D-5L (EuroQol 5-Dimensions 5-Levels) health questionnaire. Data were analyzed using both parametric and non-parametric tests at a 5 % significance level.

Results

Following the intervention, the P. vulgare group showed a significant reduction in PMS symptom severity and duration, along with an improvement in EQ-5D-5L scores, compared to the placebo group (p < 0.001). The mean reduction in PMSS scores from baseline to the end of the third treatment cycle was 44.23 (95 % CI: 39.81–48.65) in the treatment group and 24.7 (95 % CI: 21.43–27.96) in the placebo group, indicating a statistically significant difference (p < 0.001). No adverse effects were reported in either group.

Discussion

The findings suggest that P. vulgare is both effective and safe in reducing the severity and duration of PMS symptoms while enhancing HRQoL. The therapeutic effects may be attributed to its anti-inflammatory and antioxidant properties, as well as its potential to modulate serotonin levels. These results support the potential of P. vulgare as a promising treatment option for women suffering from PMS.

Conclusion

P. vulgare was more efficacious than the placebo in reducing PMS and improving the woman’s HRQoL.

背景与目的经前综合征（PMS）严重影响育龄妇女的生活质量，扰乱个人和社会关系。本研究旨在评价茯苓多糖（Bisfayej）缓解经前症候症状和改善健康相关生活质量（HRQoL）的有效性和安全性。方法60名确诊为经前综合症的妇女被随机分配接受两粒普通假单抗胶囊（1000 mg）或安慰剂。从月经周期的第16天到下一个月经周期的第5天，每天两次给予治疗，持续三个月经周期。主要结果是症状严重程度的变化，由经前综合征量表（PMSS）测量，以及症状持续时间的变化，使用经前跟踪表记录。次要结局采用EQ-5D-5L （EuroQol 5-Dimensions 5-Levels）健康问卷进行评估。使用参数检验和非参数检验对数据进行分析，显著性水平为5 %。结果干预后，与安慰剂组相比，p . vulgare组经前症候群症状严重程度和持续时间显著降低，EQ-5D-5L评分显著改善（p <； 0.001）。从基线到第三个治疗周期结束时，治疗组PMSS评分平均下降44.23(95 % CI: 39.81-48.65)，安慰剂组平均下降24.7(95 % CI: 21.43-27.96)，差异有统计学意义（p <； 0.001）。两组均无不良反应报告。本研究结果提示，在降低经前症候群症状的严重程度和持续时间，同时提高HRQoL方面，缬草既有效又安全。这种治疗效果可能归因于它的抗炎和抗氧化特性，以及它调节血清素水平的潜力。这些结果支持了普通假单胞菌作为治疗经前综合症女性的一种有希望的选择。vulgare在减少经前综合症和改善女性HRQoL方面比安慰剂更有效。

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