Advances in Nutrition最新文献_第7页

Adolescent Dietary Intake and Breast Cancer in Adulthood: A Systematic Review and Meta-analysis 青少年饮食摄入与成年期乳腺癌：一项系统综述和荟萃分析。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-08-26 DOI: 10.1016/j.advnut.2025.100503

Gladys Huiyun Lim , Ying Cong Ryan Shea Tan , Ethan Lee , Christine Kim Yan Loo , Nivetha Kumar , Mary Foong-Fong Chong , Airu Chia

Adolescence represents a key opportunity for breast cancer prevention, as the rapid proliferation of breast tissue during puberty creates a critical window of vulnerability for the development of cancerous cells. With increasing research on adolescent dietary factors and breast cancer risk, we conducted a systematic review and meta-analysis to summarize the associations between adolescent diet and risk of breast cancer in adulthood, as well as benign breast disease (BBD) and high mammographic breast density, which are markers for breast cancer. We searched Web of Science, Ovid MEDLINE, Cochrane CENTRAL, and Embase for epidemiological studies assessing dietary intakes in adolescent girls (aged 10–18 y), published through 16 October, 2024, with no language or time restrictions. Study quality was assessed using the Newcastle-Ottawa Scale, and results were pooled using random-effects models. The review included 51 studies, mostly from the United States, with the majority relying on adult recall of adolescent diet, and only 20 studies were assessed as high quality. Higher adolescent intakes of fruits and vegetables [relative risk (RR): 0.90; 95% confidence interval (CI): 0.82, 0.99; n = 3 studies], soy (RR: 0.67; 95% CI: 0.55, 0.82; n = 3), dietary fiber (RR: 0.78; 95% CI: 0.67, 0.92; n = 3), and vegetable fat (RR: 0.76; 95% CI: 0.66, 0.88; n = 2) were associated with lower risks of breast cancer in adulthood. No significant associations were observed for meat and poultry, fish, processed meat/fish, eggs, dairy, milk, grains, alcohol, total fat, animal fat, and isoflavone. Additionally, greater consumption of dietary fiber (RR: 0.64; 95% CI: 0.50, 0.82; n = 2) and vitamin D (RR: 0.77; 95% CI: 0.62, 0.95; n = 2) during adolescence was associated with lower risks of BBD, whereas no dietary associations were observed for mammographic breast density. Our findings underscore the importance of both diet and timing in breast cancer prevention. Future well-designed prospective life course studies are needed to strengthen this evidence base.

This systematic review and meta-analysis was registered with PROSPERO (CRD42024532597).

青春期是预防乳腺癌的关键时机，因为青春期乳房组织的快速增殖为癌细胞的发展创造了一个关键的脆弱性窗口。随着青少年饮食因素与乳腺癌风险的研究越来越多，我们进行了系统回顾和荟萃分析，总结青少年饮食与成年后乳腺癌风险的关系，以及乳腺癌的良性乳腺疾病（BBD）和高乳腺密度，这是乳腺癌的标志。我们检索了Web of Science， Ovid MEDLINE， Cochrane CENTRAL和Embase，以评估青春期女孩（10-18岁）饮食摄入量的流行病学研究，这些研究发表于2024年10月16日，没有语言或时间限制。使用纽卡斯尔-渥太华量表评估研究质量，并使用随机效应模型汇总结果。该综述包括51项研究，大部分来自美国，其中大多数依赖于成年人对青少年饮食的回忆，只有20项研究被评估为高质量。青少年摄入较多的水果和蔬菜（RR: 0.90; 95% CI: 0.82, 0.99; n=3项研究）、大豆（RR: 0.67; 95% CI: 0.55, 0.82; n=3）、膳食纤维（RR: 0.78; 95% CI: 0.67, 0.92; n=3）和植物脂肪（RR: 0.76; 95% CI: 0.66, 0.88; n=2）与成年后患乳腺癌的风险较低相关。肉类和家禽、鱼类、加工肉类/鱼类、蛋类、乳制品、牛奶、谷物、酒精、总脂肪、动物脂肪和异黄酮均未观察到显著相关性。此外，在青春期摄入更多的膳食纤维（RR: 0.64; 95% CI: 0.50, 0.82; n=2）和维生素D （RR: 0.77; 95% CI: 0.62, 0.95; n=2）与较低的BBD风险相关，而在乳房x光检查中没有观察到饮食与乳腺密度的关联。我们的发现强调了饮食和时间对乳腺癌预防的重要性。未来需要精心设计的前瞻性生命历程研究来加强这一证据基础。注册：该系统评价和荟萃分析在普洛斯彼罗注册（CRD42024532597）。意义声明：据我们所知，这是第一次全面回顾和量化青少年摄入各种饮食成分与成年后乳腺癌风险之间的关系。目前预防乳腺癌的饮食策略在很大程度上是由涉及成年人的研究提供的流行病学证据提供的。我们的发现为青春期饮食暴露与乳腺癌发展之间的潜在联系提供了初步的见解。我们还确定了青少年研究中的关键差距，强调需要继续开展针对形成时期的高质量研究，为未来的预防工作提供信息。

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引用次数: 0

The Use of Organoid Cultures in Advancing Nutrition Research 类器官培养在促进营养研究中的应用。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-08-19 DOI: 10.1016/j.advnut.2025.100489

Kalhara R Menikdiwela , Margie J Lenis , Judith Storch

The importance of food and nutrients in human health and chronic disease progression has been appreciated for centuries. Crucial developments enabling understanding of the complex interactions between dietary patterns and health were made in the 20th century, owing in part to improvements in in vitro cell culture methods. Such 2-dimensional (2D) cell lines remain extensively used to study the molecular mechanisms through which nutrients regulate cellular homeostasis. Nevertheless, they do not recapitulate the in vivo environment and the complexity associated with tissues and organs, which invariably contain multiple cell types. Thus, findings from 2D cell cultures may not be directly applicable or representative of the in vivo situation. By contrast, organoids are 3D tissue structures capable of mimicking structural, functional, and multicellular features of an intact organ, and are becoming increasingly used to carry out in-depth cell and molecular level studies. In particular, the use of intestinal organoids in food and nutrition research has expanded in recent years due to the greater suitability of organoids relative to 2D cultures for investigating nutrient uptake, transport, metabolism, and host-microbiome interactions. In the present review, we summarize the emerging role and contributions of organoids, with emphasis on intestinal organoids, in nutrition research and intestinal health. We further highlight current limitations of organoid cultures and discuss potential future strategies to improve the use of organoids as a preferred model for investigations in the nutritional sciences.

几个世纪以来，人们一直认识到食物和营养素对人类健康和慢性疾病进展的重要性。由于体外细胞培养方法的改进，20世纪取得了重大进展，使人们能够了解饮食模式与健康之间的复杂相互作用。这种二维（2D）细胞系仍然广泛用于研究营养物质调节细胞稳态的分子机制。然而，它们并不能概括体内环境，以及与组织和器官相关的复杂性，这些组织和器官总是包含多种细胞类型。因此，2D细胞培养的结果可能不直接适用或不代表体内情况。相比之下，类器官是三维（3D）组织结构，能够模仿完整器官的结构、功能和多细胞特征，并且越来越多地用于进行深入的细胞和分子水平研究。特别是，近年来，肠道类器官在食品和营养研究中的应用正在扩大，因为类器官相对于二维培养物更适合研究营养摄取、运输、代谢和宿主-微生物组相互作用。本文综述了类器官在营养研究和肠道健康中的作用和贡献，重点介绍了肠道类器官。我们进一步强调了目前类器官培养的局限性，并讨论了潜在的未来策略，以改善类器官作为营养科学研究的首选模型的使用。

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引用次数: 0

Dietary Patterns and Diet Quality before and/or during Pregnancy and How These Affect Birth Outcomes: A Systematic Review and Meta-analysis 怀孕前和/或怀孕期间的饮食模式和饮食质量以及它们如何影响分娩结果：一项系统回顾和荟萃分析。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-08-12 DOI: 10.1016/j.advnut.2025.100490

Cristal Salatas , Anja Bronnert , Robyn Lawrence , Tanith Alexander , Clare Wall , Frank H Bloomfield , Luling Lin

Limited consistent evidence exists on how diet quality before and during pregnancy influences preterm birth and low birthweight risk. This study aims to assess whether diet quality based on dietary patterns before and during pregnancy affects preterm birth and low birthweight risk. We systematically searched 3 electronic databases and 4 registries for randomized controlled trials (RCTs) and quasi-RCTs without restrictions on publication date or language until 22 November, 2024. Included RCTs evaluated dietary patterns to enhance diet quality before/during pregnancy compared with a usual diet or placebo. Results were synthesized using random-effects meta-analyses with risk ratios (RRs) and 95% confidence intervals. Study quality was assessed using the Cochrane Risk of Bias 1 tool, and certainty of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach. Twenty-nine RCTs (7367 participants) were included. Improved diet quality through dietary patterns providing the recommended macronutrient intake or high unsaturated fats before and during pregnancy reduced the incidence of low birthweight (<2500 g) (7 RCTs, 2178 participants, RR 0.53 [0.37, 0.77], low certainty of evidence) and have potential benefit for reducing preterm birth (15 RCTs, 4949 participants, RR 0.79 [0.62, 1.02], low certainty of evidence) compared with usual diet. The data available support interventions starting in the first trimester (RR 0.30 [0.11, 0.80]), lasting 4–7 mo (RR 0.52 [0.37, 0.73]), with similar effects in both high-/upper-middle-income [RR 0.44 (0.19, 10.04)] and lower-middle-income (RR 0.44 [0.31, 0.63]) populations, especially in low-risk women (RR 0.52 [0.37, 0.73]). Diets providing the recommended macronutrient intake or high in unsaturated fats significantly reduced risk of low birthweight when initiated in the first trimester and maintained for 4–7 mo, regardless of country-level socioeconomic context. Healthcare providers should consider recommending dietary patterns emphasizing whole foods and high-quality fats as part of early prenatal care.

This trial was registered at PROSPERO as CRD42023462517.

背景：关于孕前和孕期饮食质量如何影响早产和低出生体重风险的证据有限。目的：评估基于孕前和孕期饮食模式的饮食质量是否影响早产和低出生体重风险。方法：系统检索3个电子数据库和4个注册库的随机对照试验（rct）和准rct，不限制发表日期和语言，截止日期为2024年11月22日。纳入的随机对照试验评估了与常规饮食或安慰剂相比，在怀孕前/怀孕期间提高饮食质量的饮食模式。结果采用随机效应荟萃分析，采用风险比（rr）和95%置信区间进行综合分析。采用Cochrane Risk of Bias 1工具评估研究质量，采用分级推荐评估、发展和评价（GRADE）方法评估证据的确定性。结果：纳入29项随机对照试验（7,367名受试者）。通过在怀孕前和怀孕期间提供推荐的大量营养素摄入量或高不饱和脂肪的饮食模式改善饮食质量，降低了低出生体重的发生率(结论：在妊娠早期开始并保持4-7个月的饮食中，提供推荐的大量营养素摄入量或高不饱和脂肪显著降低了低出生体重的风险，无论国家层面的社会经济背景如何。医疗保健提供者应考虑推荐强调天然食物和高质量脂肪的饮食模式，作为早期产前护理的一部分。本系统评价在PROSPERO注册为CRD42023462517。意义声明：我们的综述提供了在怀孕早期开始饮食干预的潜在重要性的证据，特别是在妊娠早期提供推荐的大量营养素摄入或高不饱和脂肪饮食，在降低不同社会经济背景下早产和低出生体重的风险方面。此外，通过探索基线风险状态如何潜在地改变干预效果，本综述提供了对影响出生结果的背景因素的更全面的理解。

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引用次数: 0

Navigating Food Insecurity in Higher Education: Using the Social Cognitive Theory to Identify Key Influences and Effective Interventions 在高等教育中导航粮食不安全：使用社会认知理论来确定关键影响和有效干预措施。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-08-01 DOI: 10.1016/j.advnut.2025.100451

Emily Sklar , Rachel E Scherr , Deborah S Fetter

Food insecurity (FI) remains a significant crisis in the United States, disproportionately affecting college students at nearly 4 times the national household average. There are a multitude of competing factors that affect food security (FS) in college, thus making it difficult to design effective interventions. This scoping review aimed to provide a comprehensive overview of recent research exploring the diverse factors that impact FS among college students. Using the Social Cognitive Theory as a guiding framework, this review aimed to identify key influences on FI, address gaps in the literature, and highlight effective interventions that can enhance FS among this vulnerable population. This review highlights how personal/cognitive factors, behaviors, and environmental components shape college students’ experiences with FI. There is a need for targeted interventions, resources, and policy changes that can help address FS-related challenges effectively in higher education.

食品不安全仍然是美国的一个重大危机，对大学生的影响是全国家庭平均水平的近四倍。影响大学食品安全的因素有很多，因此很难设计有效的干预措施。本文旨在对影响大学生食品安全的各种因素的最新研究进行全面概述。本综述以社会认知理论为指导框架，旨在确定粮食不安全的主要影响因素，解决文献中的空白，并强调可以增强弱势群体粮食安全的有效干预措施。这篇综述强调了个人/认知因素、行为和环境因素如何影响大学生的粮食不安全经历。需要有针对性的干预措施、资源和政策变革，以帮助有效解决高等教育中与粮食安全相关的挑战。

引用次数: 0

A Theory-Informed Review of Food Insecurity in Higher Education: Determinants, Gaps, and Policy Implications 高等教育中粮食不安全的理论综述：决定因素、差距和政策影响。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-08-01 DOI: 10.1016/j.advnut.2025.100462

Hiwot Abebe Haileslassie

引用次数: 0

Optimal Intake of Animal-Source Foods: A Scoping Review to Inform a New WHO Guideline 动物源性食品的最佳摄入量：为世卫组织新指南提供信息的范围审查。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-08-01 DOI: 10.1016/j.advnut.2025.100467

Magali Rios-Leyvraz, Jason Montez

Currently, the amount and types of animal-source foods that might be part of a healthy diet remain unclear. This scoping review was commissioned by the WHO for the development of a new guideline on optimal intake of animal-source foods and aimed to collect and describe the evidence available on animal-source foods and health outcomes. A systematic search of Embase, Medline, and PubMed, complemented with a search of recent nutrition guidelines, was conducted to identify systematic, scoping, and umbrella reviews published between 2019 and 2024. Reviews of prospective observational and interventional studies with participants ≥2 y from the general population, including pregnant women, assessing the effects of animal-source foods (red meat, poultry, fish, eggs, dairy) and as comparators selected protein-rich plant-source foods on any health outcome were included. Using a mining approach, prospective observational and interventional primary studies identified in the reviews were extracted. Research availability and gaps were depicted using evidence maps. From the 7458 records identified, a total of 652 reviews were included, encompassing 1626 eligible publications from 488 unique cohorts in 65 countries and 480 eligible publications from 387 unique trials in 37 countries. Single health outcomes were grouped together into 29 groups. The most often researched outcome groups were cancer, cardiovascular diseases, diabetes, body weight and composition, and all-cause mortality. Evidence gaps were identified in older adults, children, and pregnant women, in food-insecure settings, in Sub-Saharan Africa, Central and South East Asia. This scoping review offers a comprehensive overview of existing evidence on animal-source foods and health outcomes and identifies key research gaps to support the development of new nutrition guidelines.

背景：目前，可能成为健康饮食一部分的动物源食品的数量和类型仍不清楚。这项工作是世卫组织委托开展的，目的是制定一项关于动物源性食品最佳摄入量的新指南。目的：本综述旨在收集和描述动物源性食品和健康结果的现有证据。方法：对Embase、Medline和PubMed进行系统检索，并对近期的营养指南进行检索，以确定2019年至2024年间发表的系统性、范围和总括性综述。纳入前瞻性观察性和干预性研究的综述，这些研究的参与者年龄≥2岁，来自普通人群，包括孕妇，评估动物源食品（肉、禽、鱼、蛋、乳制品）的影响，并作为比较，选择富含蛋白质的植物源食品对任何健康结果的影响。采用挖掘方法，提取了综述中确定的前瞻性观察性和干预性初步研究。利用证据图描述了研究的可用性和差距。结果：从确定的7458条记录中，共纳入652篇综述，包括来自65个国家的488个独特队列的1626篇符合条件的出版物，以及来自37个国家的387个独特试验的480篇符合条件的出版物。单一健康结果被分为29组。最常被研究的结果组是癌症、心血管疾病、糖尿病、体重和成分，以及全因死亡率。在撒哈拉以南非洲、中亚和东南亚，粮食不安全地区的老年人、儿童和孕妇中发现了证据缺口。结论：这项范围审查对动物源食品和健康结果的现有证据进行了全面概述，并确定了关键的研究差距，以支持制定新的营养指南。重要性声明：尽管人们对健康和可持续饮食中动物源食品的最佳摄入量越来越感兴趣和争论，但据我们所知，没有系统的综述总结了所有动物源食品和无限健康结果的可用证据。通过这一范围综述，我们在证据差距图的帮助下，综合了所有动物源性食品和所有健康结果的所有可获得的关于该主题的所有综述，这些综述可用于制定基于食物的营养指南。

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引用次数: 0

Treatment of Undernutrition in Pregnancy Requires Adequate Food and Inflammation Control 观点：治疗妊娠期营养不良需要充足的食物和控制炎症。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-08-01 DOI: 10.1016/j.advnut.2025.100479

David Taylor Hendrixson , Ashleen Lee , Eliza Kleban , Kevin B Stephenson , Aminata S Koroma , Mark J Manary

Undernutrition in pregnancy remains a substantial problem worldwide, disproportionately affecting females living in low- and middle-income countries where food insecurity and limited access to high-quality nutrition exacerbate maternal and fetal health risks. Undernutrition during this critical time in the lifecycle can have adverse effects on both the pregnant female and her offspring. Despite the widespread recognition of this issue, current international guidelines provide insufficient direction on optimal nutritional management strategies. Most clinical trial evidence has yielded inconclusive results. This perspective synthesizes evidence on current management strategies in addressing macronutrient and micronutrient deficiencies in pregnancy. Additionally, we examine the critical role of inflammation in moderating the effectiveness of nutritional interventions and discuss emerging strategies that integrate infection control with nutrition to optimize maternal and neonatal outcomes. Given the limitations of existing management strategies, there is an urgent need for more comprehensive, evidence-based guidelines to improve pregnancy outcomes for undernourished females worldwide.

孕期营养不足仍然是世界范围内的一个重大问题，对生活在低收入和中等收入国家的妇女的影响尤为严重，在这些国家，粮食不安全和获得高质量营养的机会有限加剧了孕产妇和胎儿健康风险。在生命周期的这一关键时期营养不良会对孕妇和她的后代产生不利影响。尽管人们普遍认识到这一问题，但目前的国际指导方针在最佳营养管理策略方面提供的指导不足。大多数临床试验证据都产生了不确定的结果。这一观点综合了目前处理妊娠期宏量营养素和微量营养素缺乏的管理策略的证据。此外，我们研究了炎症在调节营养干预有效性中的关键作用，并讨论了将感染控制与营养相结合以优化孕产妇和新生儿结局的新兴策略。鉴于现有管理策略的局限性，迫切需要制定更全面、基于证据的指南，以改善全世界营养不良妇女的妊娠结局。意义声明：该观点提供了证据，表明妊娠期营养不良仍然是全球的一个重要问题，目前的管理策略仍然不足。基于这些发现，该观点敦促进一步研究和国际支持，以确定管理这一严重疾病的最佳策略。

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引用次数: 0

Relevance of Mathematical Optimization as a Tool for Diet Modeling in the Development of Food-Based Dietary Recommendations in Sub-Saharan Africa: A Scoping Review 数学优化在撒哈拉以南非洲以食物为基础的饮食建议发展中作为饮食建模工具的相关性：范围审查。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-08-01 DOI: 10.1016/j.advnut.2025.100480

Sakiko Shiratori , MG Dilini Abeysekara

This study aimed to understand the role of mathematical programming in the development of food-based dietary recommendations (FBRs) in sub-Saharan Africa (SSA), identify current limitations, and highlight opportunities for advancing evidence-based dietary interventions. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews, a systematic search from January 2000 to May 2024 identified 97 relevant studies. Among these, 30 studies spanning 12 SSA countries (of 48 countries and territories in SSA) met the inclusion criteria. The reviewed studies leveraged linear programming (LP) or extensions of LP (i.e., linear goal programming) to formulate FBRs by optimizing current dietary patterns to meet nutritional needs and gaps (n = 24), developing nutritionally and regionally optimized and cost-minimized food baskets (n = 4), and describing the use of LP as a method for designing population-specific food-based dietary guidelines (n = 2). The primary goal of the reviewed studies is to develop nutritionally adequate and economically affordable food patterns, rather than to address multiple chronic nutrition-related conditions simultaneously, reflecting the distinct priorities of diet modeling in low-resource settings compared with those of resource-rich contexts. The formulated FBRs and optimized diets are often defined for specific demographic groups, with a limited geographic scope reflecting regional priorities. Diets can be optimized both nutritionally and economically by prioritizing locally available food groups and items; however, in some cases, additional supplementation and or inclusion of rarely consumed nutrient-dense foods may be necessary. Mathematical optimization, particularly LP, is a valuable tool for addressing dietary challenges and developing evidence-based, context-specific FBRs. Its use is facilitated by the availability of user-friendly software. However, its successful application requires high-quality input data, consideration of behavioral and practical aspects, and interdisciplinary collaboration. High-quality input data and incorporating sociocultural contexts are critical for leveraging mathematical optimization to inform inclusive and effective dietary recommendations in SSA.

本研究旨在了解数学规划在撒哈拉以南非洲（SSA）基于食物的饮食建议（FBRs）发展中的作用，确定当前的局限性，并强调推进循证饮食干预的机会。根据PRISMA扩展范围审查（PRISMA- scr），从2000年1月到2024年5月的系统检索确定了97项相关研究。其中，来自12个SSA国家（在SSA的48个国家和地区中）的30项研究符合纳入标准。所回顾的研究利用线性规划（LP）或线性目标规划的扩展（即线性目标规划），通过优化当前的饮食模式以满足营养需求和差距（n=24），开发营养和区域优化和成本最小化的食物篮子（n=4），以及将LP作为设计特定人群的基于食物的饮食指南的方法（n=2）来制定fbr。所审查的研究的主要目标是开发营养充足且经济上负担得起的食物模式，而不是同时解决多种慢性营养相关疾病，这反映了与资源丰富环境相比，低资源环境中饮食建模的独特优先事项。制定的fbr和优化的饮食通常是针对特定的人口群体确定的，地理范围有限，反映了区域优先事项。通过优先考虑当地可获得的食物种类和项目，可以在营养和经济上优化饮食；然而，在某些情况下，可能需要额外补充或包含很少食用的营养密集食物。数学优化，特别是LP，是解决饮食挑战和开发基于证据的、具体情况的fbr的宝贵工具。用户友好软件的可用性促进了它的使用。然而，它的成功应用需要高质量的输入数据，考虑行为和实践方面，以及跨学科的合作。高质量的输入数据和融入社会文化背景对于利用数学优化为SSA提供包容和有效的饮食建议至关重要。

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引用次数: 0

Current Evidence on Optimal Intake of Animal-Source Foods and Health Status 目前关于动物源性食品最佳摄入量和健康状况的证据。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-08-01 DOI: 10.1016/j.advnut.2025.100466

Lukas Schwingshackl , Sabrina Schlesinger

引用次数: 0

Perspective: Biomarkers of Aging in Human Nutrition Research—A Focus on Applications, Challenges, and Opportunities 展望：生物标志物在人类营养研究中的应用、挑战和机遇。

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition

Pub Date : 2025-07-28 DOI: 10.1016/j.advnut.2025.100486

Keeva NM Loughlin , Pol Grootswagers , Guido Camps , Lisette CPGM de Groot

Predictive algorithm-based biomarkers of aging (BoA), such as aging clocks, are increasingly applied within human nutrition research. Despite great promise of these BoA, validation efforts and guidelines for implementation are lagging behind the vast and growing number of available biomarkers, complicating their use and introducing variance across studies. Therefore, in the current perspective paper, we provide practical insights and an initial set of recommendations for consistent future implementation of BoA within nutrition research based on current knowledge, both on a general level and within different research scenarios. We critically reflect on existing observational and experimental nutrition research, and outline the potential application of BoA in identifying at-risk groups, exploring heterogeneity underlying aging and nutritional effects, and personalized approaches. This work aims to support nutritional researchers in making informed decisions on contextually appropriate biomarkers and provides directions for future nutritional research involving BoA, because, despite much needed advancements, we consider BoA exciting and promising tools in nutrition research.

基于预测算法的衰老生物标志物（BoA），如衰老时钟，越来越多地应用于人类营养研究。尽管这些BoA有很大的前景，但验证工作和实施指南落后于大量和不断增长的可用生物标志物，使它们的使用复杂化，并在研究中引入了差异。因此，在当前的前瞻性文章中，我们根据现有的知识，在一般水平和不同的研究方案中，为营养研究中一致的未来实施BoA提供了实用的见解和初步建议。我们批判性地反思了现有的观察性和实验性营养研究，并概述了BoA在识别高危人群、探索衰老和营养效应的异质性以及个性化方法方面的潜在应用。这项工作旨在支持营养研究人员在适当的生物标志物上做出明智的决定，并为未来涉及BoA的营养研究提供方向，因为尽管还需要很多进展，我们认为BoA是营养研究中令人兴奋和有前途的工具。

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引用次数: 0