Pub Date : 2025-08-19DOI: 10.1016/j.advnut.2025.100489
Kalhara R Menikdiwela , Margie J Lenis , Judith Storch
The importance of food and nutrients in human health and chronic disease progression has been appreciated for centuries. Crucial developments enabling understanding of the complex interactions between dietary patterns and health were made in the 20th century, owing in part to improvements in in vitro cell culture methods. Such 2-dimensional (2D) cell lines remain extensively used to study the molecular mechanisms through which nutrients regulate cellular homeostasis. Nevertheless, they do not recapitulate the in vivo environment and the complexity associated with tissues and organs, which invariably contain multiple cell types. Thus, findings from 2D cell cultures may not be directly applicable or representative of the in vivo situation. By contrast, organoids are 3D tissue structures capable of mimicking structural, functional, and multicellular features of an intact organ, and are becoming increasingly used to carry out in-depth cell and molecular level studies. In particular, the use of intestinal organoids in food and nutrition research has expanded in recent years due to the greater suitability of organoids relative to 2D cultures for investigating nutrient uptake, transport, metabolism, and host-microbiome interactions. In the present review, we summarize the emerging role and contributions of organoids, with emphasis on intestinal organoids, in nutrition research and intestinal health. We further highlight current limitations of organoid cultures and discuss potential future strategies to improve the use of organoids as a preferred model for investigations in the nutritional sciences.
{"title":"The Use of Organoid Cultures in Advancing Nutrition Research","authors":"Kalhara R Menikdiwela , Margie J Lenis , Judith Storch","doi":"10.1016/j.advnut.2025.100489","DOIUrl":"10.1016/j.advnut.2025.100489","url":null,"abstract":"<div><div>The importance of food and nutrients in human health and chronic disease progression has been appreciated for centuries. Crucial developments enabling understanding of the complex interactions between dietary patterns and health were made in the 20th century, owing in part to improvements in in vitro cell culture methods. Such 2-dimensional (2D) cell lines remain extensively used to study the molecular mechanisms through which nutrients regulate cellular homeostasis. Nevertheless, they do not recapitulate the in vivo environment and the complexity associated with tissues and organs, which invariably contain multiple cell types. Thus, findings from 2D cell cultures may not be directly applicable or representative of the in vivo situation. By contrast, organoids are 3D tissue structures capable of mimicking structural, functional, and multicellular features of an intact organ, and are becoming increasingly used to carry out in-depth cell and molecular level studies. In particular, the use of intestinal organoids in food and nutrition research has expanded in recent years due to the greater suitability of organoids relative to 2D cultures for investigating nutrient uptake, transport, metabolism, and host-microbiome interactions. In the present review, we summarize the emerging role and contributions of organoids, with emphasis on intestinal organoids, in nutrition research and intestinal health. We further highlight current limitations of organoid cultures and discuss potential future strategies to improve the use of organoids as a preferred model for investigations in the nutritional sciences.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 10","pages":"Article 100489"},"PeriodicalIF":9.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-12DOI: 10.1016/j.advnut.2025.100490
Cristal Salatas , Anja Bronnert , Robyn Lawrence , Tanith Alexander , Clare Wall , Frank H Bloomfield , Luling Lin
Limited consistent evidence exists on how diet quality before and during pregnancy influences preterm birth and low birthweight risk. This study aims to assess whether diet quality based on dietary patterns before and during pregnancy affects preterm birth and low birthweight risk. We systematically searched 3 electronic databases and 4 registries for randomized controlled trials (RCTs) and quasi-RCTs without restrictions on publication date or language until 22 November, 2024. Included RCTs evaluated dietary patterns to enhance diet quality before/during pregnancy compared with a usual diet or placebo. Results were synthesized using random-effects meta-analyses with risk ratios (RRs) and 95% confidence intervals. Study quality was assessed using the Cochrane Risk of Bias 1 tool, and certainty of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach. Twenty-nine RCTs (7367 participants) were included. Improved diet quality through dietary patterns providing the recommended macronutrient intake or high unsaturated fats before and during pregnancy reduced the incidence of low birthweight (<2500 g) (7 RCTs, 2178 participants, RR 0.53 [0.37, 0.77], low certainty of evidence) and have potential benefit for reducing preterm birth (15 RCTs, 4949 participants, RR 0.79 [0.62, 1.02], low certainty of evidence) compared with usual diet. The data available support interventions starting in the first trimester (RR 0.30 [0.11, 0.80]), lasting 4–7 mo (RR 0.52 [0.37, 0.73]), with similar effects in both high-/upper-middle-income [RR 0.44 (0.19, 10.04)] and lower-middle-income (RR 0.44 [0.31, 0.63]) populations, especially in low-risk women (RR 0.52 [0.37, 0.73]). Diets providing the recommended macronutrient intake or high in unsaturated fats significantly reduced risk of low birthweight when initiated in the first trimester and maintained for 4–7 mo, regardless of country-level socioeconomic context. Healthcare providers should consider recommending dietary patterns emphasizing whole foods and high-quality fats as part of early prenatal care.
This trial was registered at PROSPERO as CRD42023462517.
背景：关于孕前和孕期饮食质量如何影响早产和低出生体重风险的证据有限。目的：评估基于孕前和孕期饮食模式的饮食质量是否影响早产和低出生体重风险。方法：系统检索3个电子数据库和4个注册库的随机对照试验（rct）和准rct，不限制发表日期和语言，截止日期为2024年11月22日。纳入的随机对照试验评估了与常规饮食或安慰剂相比，在怀孕前/怀孕期间提高饮食质量的饮食模式。结果采用随机效应荟萃分析，采用风险比（rr）和95%置信区间进行综合分析。采用Cochrane Risk of Bias 1工具评估研究质量，采用分级推荐评估、发展和评价（GRADE）方法评估证据的确定性。结果：纳入29项随机对照试验（7,367名受试者）。通过在怀孕前和怀孕期间提供推荐的大量营养素摄入量或高不饱和脂肪的饮食模式改善饮食质量，降低了低出生体重的发生率(结论：在妊娠早期开始并保持4-7个月的饮食中，提供推荐的大量营养素摄入量或高不饱和脂肪显著降低了低出生体重的风险，无论国家层面的社会经济背景如何。医疗保健提供者应考虑推荐强调天然食物和高质量脂肪的饮食模式，作为早期产前护理的一部分。本系统评价在PROSPERO注册为CRD42023462517。意义声明：我们的综述提供了在怀孕早期开始饮食干预的潜在重要性的证据，特别是在妊娠早期提供推荐的大量营养素摄入或高不饱和脂肪饮食，在降低不同社会经济背景下早产和低出生体重的风险方面。此外，通过探索基线风险状态如何潜在地改变干预效果，本综述提供了对影响出生结果的背景因素的更全面的理解。
{"title":"Dietary Patterns and Diet Quality before and/or during Pregnancy and How These Affect Birth Outcomes: A Systematic Review and Meta-analysis","authors":"Cristal Salatas , Anja Bronnert , Robyn Lawrence , Tanith Alexander , Clare Wall , Frank H Bloomfield , Luling Lin","doi":"10.1016/j.advnut.2025.100490","DOIUrl":"10.1016/j.advnut.2025.100490","url":null,"abstract":"<div><div>Limited consistent evidence exists on how diet quality before and during pregnancy influences preterm birth and low birthweight risk. This study aims to assess whether diet quality based on dietary patterns before and during pregnancy affects preterm birth and low birthweight risk. We systematically searched 3 electronic databases and 4 registries for randomized controlled trials (RCTs) and quasi-RCTs without restrictions on publication date or language until 22 November, 2024. Included RCTs evaluated dietary patterns to enhance diet quality before/during pregnancy compared with a usual diet or placebo. Results were synthesized using random-effects meta-analyses with risk ratios (RRs) and 95% confidence intervals. Study quality was assessed using the Cochrane Risk of Bias 1 tool, and certainty of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach. Twenty-nine RCTs (7367 participants) were included. Improved diet quality through dietary patterns providing the recommended macronutrient intake or high unsaturated fats before and during pregnancy reduced the incidence of low birthweight (<2500 g) (7 RCTs, 2178 participants, RR 0.53 [0.37, 0.77], low certainty of evidence) and have potential benefit for reducing preterm birth (15 RCTs, 4949 participants, RR 0.79 [0.62, 1.02], low certainty of evidence) compared with usual diet. The data available support interventions starting in the first trimester (RR 0.30 [0.11, 0.80]), lasting 4–7 mo (RR 0.52 [0.37, 0.73]), with similar effects in both high-/upper-middle-income [RR 0.44 (0.19, 10.04)] and lower-middle-income (RR 0.44 [0.31, 0.63]) populations, especially in low-risk women (RR 0.52 [0.37, 0.73]). Diets providing the recommended macronutrient intake or high in unsaturated fats significantly reduced risk of low birthweight when initiated in the first trimester and maintained for 4–7 mo, regardless of country-level socioeconomic context. Healthcare providers should consider recommending dietary patterns emphasizing whole foods and high-quality fats as part of early prenatal care.</div><div>This trial was registered at PROSPERO as CRD42023462517.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 10","pages":"Article 100490"},"PeriodicalIF":9.2,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.advnut.2025.100451
Emily Sklar , Rachel E Scherr , Deborah S Fetter
Food insecurity (FI) remains a significant crisis in the United States, disproportionately affecting college students at nearly 4 times the national household average. There are a multitude of competing factors that affect food security (FS) in college, thus making it difficult to design effective interventions. This scoping review aimed to provide a comprehensive overview of recent research exploring the diverse factors that impact FS among college students. Using the Social Cognitive Theory as a guiding framework, this review aimed to identify key influences on FI, address gaps in the literature, and highlight effective interventions that can enhance FS among this vulnerable population. This review highlights how personal/cognitive factors, behaviors, and environmental components shape college students’ experiences with FI. There is a need for targeted interventions, resources, and policy changes that can help address FS-related challenges effectively in higher education.
{"title":"Navigating Food Insecurity in Higher Education: Using the Social Cognitive Theory to Identify Key Influences and Effective Interventions","authors":"Emily Sklar , Rachel E Scherr , Deborah S Fetter","doi":"10.1016/j.advnut.2025.100451","DOIUrl":"10.1016/j.advnut.2025.100451","url":null,"abstract":"<div><div>Food insecurity (FI) remains a significant crisis in the United States, disproportionately affecting college students at nearly 4 times the national household average. There are a multitude of competing factors that affect food security (FS) in college, thus making it difficult to design effective interventions. This scoping review aimed to provide a comprehensive overview of recent research exploring the diverse factors that impact FS among college students. Using the Social Cognitive Theory as a guiding framework, this review aimed to identify key influences on FI, address gaps in the literature, and highlight effective interventions that can enhance FS among this vulnerable population. This review highlights how personal/cognitive factors, behaviors, and environmental components shape college students’ experiences with FI. There is a need for targeted interventions, resources, and policy changes that can help address FS-related challenges effectively in higher education.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 8","pages":"Article 100451"},"PeriodicalIF":9.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.advnut.2025.100467
Magali Rios-Leyvraz, Jason Montez
Currently, the amount and types of animal-source foods that might be part of a healthy diet remain unclear. This scoping review was commissioned by the WHO for the development of a new guideline on optimal intake of animal-source foods and aimed to collect and describe the evidence available on animal-source foods and health outcomes. A systematic search of Embase, Medline, and PubMed, complemented with a search of recent nutrition guidelines, was conducted to identify systematic, scoping, and umbrella reviews published between 2019 and 2024. Reviews of prospective observational and interventional studies with participants ≥2 y from the general population, including pregnant women, assessing the effects of animal-source foods (red meat, poultry, fish, eggs, dairy) and as comparators selected protein-rich plant-source foods on any health outcome were included. Using a mining approach, prospective observational and interventional primary studies identified in the reviews were extracted. Research availability and gaps were depicted using evidence maps. From the 7458 records identified, a total of 652 reviews were included, encompassing 1626 eligible publications from 488 unique cohorts in 65 countries and 480 eligible publications from 387 unique trials in 37 countries. Single health outcomes were grouped together into 29 groups. The most often researched outcome groups were cancer, cardiovascular diseases, diabetes, body weight and composition, and all-cause mortality. Evidence gaps were identified in older adults, children, and pregnant women, in food-insecure settings, in Sub-Saharan Africa, Central and South East Asia. This scoping review offers a comprehensive overview of existing evidence on animal-source foods and health outcomes and identifies key research gaps to support the development of new nutrition guidelines.
{"title":"Optimal Intake of Animal-Source Foods: A Scoping Review to Inform a New WHO Guideline","authors":"Magali Rios-Leyvraz, Jason Montez","doi":"10.1016/j.advnut.2025.100467","DOIUrl":"10.1016/j.advnut.2025.100467","url":null,"abstract":"<div><div>Currently, the amount and types of animal-source foods that might be part of a healthy diet remain unclear. This scoping review was commissioned by the WHO for the development of a new guideline on optimal intake of animal-source foods and aimed to collect and describe the evidence available on animal-source foods and health outcomes. A systematic search of Embase, Medline, and PubMed, complemented with a search of recent nutrition guidelines, was conducted to identify systematic, scoping, and umbrella reviews published between 2019 and 2024. Reviews of prospective observational and interventional studies with participants ≥2 y from the general population, including pregnant women, assessing the effects of animal-source foods (red meat, poultry, fish, eggs, dairy) and as comparators selected protein-rich plant-source foods on any health outcome were included. Using a mining approach, prospective observational and interventional primary studies identified in the reviews were extracted. Research availability and gaps were depicted using evidence maps. From the 7458 records identified, a total of 652 reviews were included, encompassing 1626 eligible publications from 488 unique cohorts in 65 countries and 480 eligible publications from 387 unique trials in 37 countries. Single health outcomes were grouped together into 29 groups. The most often researched outcome groups were cancer, cardiovascular diseases, diabetes, body weight and composition, and all-cause mortality. Evidence gaps were identified in older adults, children, and pregnant women, in food-insecure settings, in Sub-Saharan Africa, Central and South East Asia. This scoping review offers a comprehensive overview of existing evidence on animal-source foods and health outcomes and identifies key research gaps to support the development of new nutrition guidelines.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 8","pages":"Article 100467"},"PeriodicalIF":9.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.advnut.2025.100479
David Taylor Hendrixson , Ashleen Lee , Eliza Kleban , Kevin B Stephenson , Aminata S Koroma , Mark J Manary
Undernutrition in pregnancy remains a substantial problem worldwide, disproportionately affecting females living in low- and middle-income countries where food insecurity and limited access to high-quality nutrition exacerbate maternal and fetal health risks. Undernutrition during this critical time in the lifecycle can have adverse effects on both the pregnant female and her offspring. Despite the widespread recognition of this issue, current international guidelines provide insufficient direction on optimal nutritional management strategies. Most clinical trial evidence has yielded inconclusive results. This perspective synthesizes evidence on current management strategies in addressing macronutrient and micronutrient deficiencies in pregnancy. Additionally, we examine the critical role of inflammation in moderating the effectiveness of nutritional interventions and discuss emerging strategies that integrate infection control with nutrition to optimize maternal and neonatal outcomes. Given the limitations of existing management strategies, there is an urgent need for more comprehensive, evidence-based guidelines to improve pregnancy outcomes for undernourished females worldwide.
{"title":"Treatment of Undernutrition in Pregnancy Requires Adequate Food and Inflammation Control","authors":"David Taylor Hendrixson , Ashleen Lee , Eliza Kleban , Kevin B Stephenson , Aminata S Koroma , Mark J Manary","doi":"10.1016/j.advnut.2025.100479","DOIUrl":"10.1016/j.advnut.2025.100479","url":null,"abstract":"<div><div>Undernutrition in pregnancy remains a substantial problem worldwide, disproportionately affecting females living in low- and middle-income countries where food insecurity and limited access to high-quality nutrition exacerbate maternal and fetal health risks. Undernutrition during this critical time in the lifecycle can have adverse effects on both the pregnant female and her offspring. Despite the widespread recognition of this issue, current international guidelines provide insufficient direction on optimal nutritional management strategies. Most clinical trial evidence has yielded inconclusive results. This perspective synthesizes evidence on current management strategies in addressing macronutrient and micronutrient deficiencies in pregnancy. Additionally, we examine the critical role of inflammation in moderating the effectiveness of nutritional interventions and discuss emerging strategies that integrate infection control with nutrition to optimize maternal and neonatal outcomes. Given the limitations of existing management strategies, there is an urgent need for more comprehensive, evidence-based guidelines to improve pregnancy outcomes for undernourished females worldwide.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 8","pages":"Article 100479"},"PeriodicalIF":9.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.advnut.2025.100480
Sakiko Shiratori , MG Dilini Abeysekara
This study aimed to understand the role of mathematical programming in the development of food-based dietary recommendations (FBRs) in sub-Saharan Africa (SSA), identify current limitations, and highlight opportunities for advancing evidence-based dietary interventions. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews, a systematic search from January 2000 to May 2024 identified 97 relevant studies. Among these, 30 studies spanning 12 SSA countries (of 48 countries and territories in SSA) met the inclusion criteria. The reviewed studies leveraged linear programming (LP) or extensions of LP (i.e., linear goal programming) to formulate FBRs by optimizing current dietary patterns to meet nutritional needs and gaps (n = 24), developing nutritionally and regionally optimized and cost-minimized food baskets (n = 4), and describing the use of LP as a method for designing population-specific food-based dietary guidelines (n = 2). The primary goal of the reviewed studies is to develop nutritionally adequate and economically affordable food patterns, rather than to address multiple chronic nutrition-related conditions simultaneously, reflecting the distinct priorities of diet modeling in low-resource settings compared with those of resource-rich contexts. The formulated FBRs and optimized diets are often defined for specific demographic groups, with a limited geographic scope reflecting regional priorities. Diets can be optimized both nutritionally and economically by prioritizing locally available food groups and items; however, in some cases, additional supplementation and or inclusion of rarely consumed nutrient-dense foods may be necessary. Mathematical optimization, particularly LP, is a valuable tool for addressing dietary challenges and developing evidence-based, context-specific FBRs. Its use is facilitated by the availability of user-friendly software. However, its successful application requires high-quality input data, consideration of behavioral and practical aspects, and interdisciplinary collaboration. High-quality input data and incorporating sociocultural contexts are critical for leveraging mathematical optimization to inform inclusive and effective dietary recommendations in SSA.
{"title":"Relevance of Mathematical Optimization as a Tool for Diet Modeling in the Development of Food-Based Dietary Recommendations in Sub-Saharan Africa: A Scoping Review","authors":"Sakiko Shiratori , MG Dilini Abeysekara","doi":"10.1016/j.advnut.2025.100480","DOIUrl":"10.1016/j.advnut.2025.100480","url":null,"abstract":"<div><div>This study aimed to understand the role of mathematical programming in the development of food-based dietary recommendations (FBRs) in sub-Saharan Africa (SSA), identify current limitations, and highlight opportunities for advancing evidence-based dietary interventions. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews, a systematic search from January 2000 to May 2024 identified 97 relevant studies. Among these, 30 studies spanning 12 SSA countries (of 48 countries and territories in SSA) met the inclusion criteria. The reviewed studies leveraged linear programming (LP) or extensions of LP (i.e., linear goal programming) to formulate FBRs by optimizing current dietary patterns to meet nutritional needs and gaps (<em>n</em> = 24), developing nutritionally and regionally optimized and cost-minimized food baskets (<em>n</em> = 4), and describing the use of LP as a method for designing population-specific food-based dietary guidelines (<em>n</em> = 2). The primary goal of the reviewed studies is to develop nutritionally adequate and economically affordable food patterns, rather than to address multiple chronic nutrition-related conditions simultaneously, reflecting the distinct priorities of diet modeling in low-resource settings compared with those of resource-rich contexts. The formulated FBRs and optimized diets are often defined for specific demographic groups, with a limited geographic scope reflecting regional priorities. Diets can be optimized both nutritionally and economically by prioritizing locally available food groups and items; however, in some cases, additional supplementation and or inclusion of rarely consumed nutrient-dense foods may be necessary. Mathematical optimization, particularly LP, is a valuable tool for addressing dietary challenges and developing evidence-based, context-specific FBRs. Its use is facilitated by the availability of user-friendly software. However, its successful application requires high-quality input data, consideration of behavioral and practical aspects, and interdisciplinary collaboration. High-quality input data and incorporating sociocultural contexts are critical for leveraging mathematical optimization to inform inclusive and effective dietary recommendations in SSA.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 8","pages":"Article 100480"},"PeriodicalIF":9.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.advnut.2025.100466
Lukas Schwingshackl , Sabrina Schlesinger
{"title":"Current Evidence on Optimal Intake of Animal-Source Foods and Health Status","authors":"Lukas Schwingshackl , Sabrina Schlesinger","doi":"10.1016/j.advnut.2025.100466","DOIUrl":"10.1016/j.advnut.2025.100466","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 8","pages":"Article 100466"},"PeriodicalIF":9.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-28DOI: 10.1016/j.advnut.2025.100486
Keeva NM Loughlin , Pol Grootswagers , Guido Camps , Lisette CPGM de Groot
Predictive algorithm-based biomarkers of aging (BoA), such as aging clocks, are increasingly applied within human nutrition research. Despite great promise of these BoA, validation efforts and guidelines for implementation are lagging behind the vast and growing number of available biomarkers, complicating their use and introducing variance across studies. Therefore, in the current perspective paper, we provide practical insights and an initial set of recommendations for consistent future implementation of BoA within nutrition research based on current knowledge, both on a general level and within different research scenarios. We critically reflect on existing observational and experimental nutrition research, and outline the potential application of BoA in identifying at-risk groups, exploring heterogeneity underlying aging and nutritional effects, and personalized approaches. This work aims to support nutritional researchers in making informed decisions on contextually appropriate biomarkers and provides directions for future nutritional research involving BoA, because, despite much needed advancements, we consider BoA exciting and promising tools in nutrition research.
{"title":"Perspective: Biomarkers of Aging in Human Nutrition Research—A Focus on Applications, Challenges, and Opportunities","authors":"Keeva NM Loughlin , Pol Grootswagers , Guido Camps , Lisette CPGM de Groot","doi":"10.1016/j.advnut.2025.100486","DOIUrl":"10.1016/j.advnut.2025.100486","url":null,"abstract":"<div><div>Predictive algorithm-based biomarkers of aging (BoA), such as aging clocks, are increasingly applied within human nutrition research. Despite great promise of these BoA, validation efforts and guidelines for implementation are lagging behind the vast and growing number of available biomarkers, complicating their use and introducing variance across studies. Therefore, in the current perspective paper, we provide practical insights and an initial set of recommendations for consistent future implementation of BoA within nutrition research based on current knowledge, both on a general level and within different research scenarios. We critically reflect on existing observational and experimental nutrition research, and outline the potential application of BoA in identifying at-risk groups, exploring heterogeneity underlying aging and nutritional effects, and personalized approaches. This work aims to support nutritional researchers in making informed decisions on contextually appropriate biomarkers and provides directions for future nutritional research involving BoA, because, despite much needed advancements, we consider BoA exciting and promising tools in nutrition research.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 9","pages":"Article 100486"},"PeriodicalIF":9.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-19DOI: 10.1016/j.advnut.2025.100483
Armando Peña , Zoe Barnsfather , Alison M Miller , Ashley Alvarado , Deanna Reinoso , Melissa Klitzman , Ann Marie Neeley , Ana Maria Linares , Katherine Harkov , Tess Phillips , Amanda Santiago , Christine Spencer , Fernanda Betti , Julie A Patterson , Ines Casanova , Karla Baquerizo , Kiran Snow , Angelica Maria Mays , Shannon Lopez , Courtnie Leeper , Richard J Holden
Increasing exclusive breastfeeding among Latino populations has the potential to reduce health disparities. There is a need for a multilevel and multidomain framework of exclusive breastfeeding determinants. This study aimed to co-create an exclusive breastfeeding determinants framework among Latino populations and map this framework using the current literature. Our community coalition convened in working groups to adapt a multilevel and multidomain determinants framework with 20 cells (4 levels × 5 domains) for exclusive breastfeeding among Latino populations. We documented all referenced determinants in working groups, and 2 independent raters deductively and inductively analyzed these specific determinants into themes by cell (level domain). An integrated scoping review mapped the determinants addressed in the literature of exclusive breastfeeding interventions among Latinos in the United States onto the framework cells. Two independent raters transcribed intervention descriptions verbatim and deductively analyzed the text using our list of determinants as the codebook. Inductive analysis allowed for emerging determinants. We mapped determinants that were addressed by theme. A total of 111 specific determinants were referenced in working groups that were categorized into 53 determinant themes. Most studies addressed Individual-level determinants at each domain (n = 11–16 studies) except for Built Environment (n = 3). At the Interpersonal level, Behavior (n = 11) and Health Care System (n = 16) domains were predominantly addressed. At the Community level, Built Environment (n = 14) and Health Care System (n = 15) domains were addressed. Most studies at the Societal level addressed the Health Care System domain but none addressed Biological, Behavior, or Built Environment domains. Extension of care, culturally relevant care, knowledge and skills, mother–infant bonding, and practitioner–dyad relationship were referenced the most of all 56 themes (n ≥ 13 each). Increasing exclusive breastfeeding among Latinos is a multifaceted challenge. Innovative areas for future work include Biological and Sociocultural domains beyond the Individual level as well as most domains at the Societal level.
{"title":"Co-creating and Mapping an Exclusive Breastfeeding Framework among Latino Populations in the United States: An Integrated Framework Adaptation Process and Scoping Review","authors":"Armando Peña , Zoe Barnsfather , Alison M Miller , Ashley Alvarado , Deanna Reinoso , Melissa Klitzman , Ann Marie Neeley , Ana Maria Linares , Katherine Harkov , Tess Phillips , Amanda Santiago , Christine Spencer , Fernanda Betti , Julie A Patterson , Ines Casanova , Karla Baquerizo , Kiran Snow , Angelica Maria Mays , Shannon Lopez , Courtnie Leeper , Richard J Holden","doi":"10.1016/j.advnut.2025.100483","DOIUrl":"10.1016/j.advnut.2025.100483","url":null,"abstract":"<div><div>Increasing exclusive breastfeeding among Latino populations has the potential to reduce health disparities. There is a need for a multilevel and multidomain framework of exclusive breastfeeding determinants. This study aimed to co-create an exclusive breastfeeding determinants framework among Latino populations and map this framework using the current literature. Our community coalition convened in working groups to adapt a multilevel and multidomain determinants framework with 20 cells (4 levels × 5 domains) for exclusive breastfeeding among Latino populations. We documented all referenced determinants in working groups, and 2 independent raters deductively and inductively analyzed these specific determinants into themes by cell (level domain). An integrated scoping review mapped the determinants addressed in the literature of exclusive breastfeeding interventions among Latinos in the United States onto the framework cells. Two independent raters transcribed intervention descriptions verbatim and deductively analyzed the text using our list of determinants as the codebook. Inductive analysis allowed for emerging determinants. We mapped determinants that were addressed by theme. A total of 111 specific determinants were referenced in working groups that were categorized into 53 determinant themes. Most studies addressed Individual-level determinants at each domain (<em>n</em> = 11–16 studies) except for Built Environment (<em>n</em> = 3). At the Interpersonal level, Behavior (<em>n</em> = 11) and Health Care System (<em>n =</em> 16) domains were predominantly addressed. At the Community level, Built Environment (<em>n =</em> 14) and Health Care System (<em>n =</em> 15) domains were addressed. Most studies at the Societal level addressed the Health Care System domain but none addressed Biological, Behavior, or Built Environment domains. Extension of care, culturally relevant care, knowledge and skills, mother–infant bonding, and practitioner–dyad relationship were referenced the most of all 56 themes (<em>n ≥</em> 13 each). Increasing exclusive breastfeeding among Latinos is a multifaceted challenge. Innovative areas for future work include Biological and Sociocultural domains beyond the Individual level as well as most domains at the Societal level.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 9","pages":"Article 100483"},"PeriodicalIF":9.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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