Iranian journal of cancer prevention最新文献_第7页

Designing and Psychometric Evaluation of Adjustment to Illness Measurement Inventory for Iranian Women With Breast Cancer 伊朗乳腺癌妇女疾病量表调整的设计与心理测量学评价

Iranian journal of cancer prevention

Pub Date : 2016-08-01 DOI: 10.17795/ijcp-5461

S. Hajian, E. Mehrabi, M. Simbar, M. Houshyari, F. Zayeri, Parastoo Hajian

Background Cancer diagnosis for everybody may be perceived as crisis and breast cancer, as the most common malignancy in women, can influence their well-being and multiple aspects of their health. So understanding that how women in various contexts and communities adjust to the illness is necessary to facilitate this adjustment and improve their quality of life. Objectives The aim of this study was to: 1) identify the core components of coping strategies to adjust to the illness in Iranian women with breast cancer perspective, 2) to develop and determine psychometric properties of a native self-report instrument to assess coping behaviors and measure the degree of adjustment with the breast cancer. Methods The present exploratory mixed method study was conducted in two consecutive stages: 1) the hermeneutic phenomenological study was done to explore the life experiences of coping styles to adjust with the breast cancer using in-depth interviews with patients that lead to item generation; 2) psychometric properties (validity and reliability) of the instrument were evaluated recruiting 340 eligible women. The item pool was reduced systematically and resulted in a 49-item instrument. Results From the qualitative stage, item pool containing 78 items related to coping strategies to adjust with the breast cancer. After eliminating unwanted statements from the results, qualitative and quantitative face and content validity, the 10 factors extracted employing construct validity were: feeling of guilt, abstention-diversion, role preservation and seeking support, efforts for threat control, confronting, fear and anxiety, role wasting, maturation and growth, isolation, and fatalism. These factors accounted for the 59.1% of variance observed. The Cronbach reliability test was carried out and alpha value of 10 factors was calculated from 0.78 to 0.87 confirming all factors were internally consistent. The scale’s stability was tested using the test-retest method. Conclusions The 49-item AIMI-IBC revealed acceptable psychometric properties. This instrument provides healthcare professionals to systematically assess the coping strategies of Iranian women with breast cancer and measure the degree of adjustment with illness.

癌症诊断对每个人来说都可能被视为危机，乳腺癌作为妇女中最常见的恶性肿瘤，可以影响她们的福祉和健康的多个方面。因此，了解不同环境和社区的女性如何适应疾病对于促进这种适应和提高她们的生活质量是必要的。目的本研究的目的是:1)确定伊朗乳腺癌妇女适应疾病的应对策略的核心组成部分;2)开发和确定一个本地自我报告工具的心理测量特性，以评估应对行为和测量乳腺癌的适应程度。方法本探索性混合方法研究分两个阶段进行:1)采用解释学现象学研究，通过对乳腺癌患者的深度访谈，探讨应对方式适应乳腺癌的生活经历，并产生项目;2)招募340名符合条件的女性，对量表的心理测量特性(效度和信度)进行评估。系统地减少了项目池，并产生了49个项目的工具。结果从定性阶段开始，共有78项题库与乳腺癌的应对策略相关。在剔除结果中不需要的陈述、定性和定量的面子效度和内容效度后，采用构念效度提取的10个因素为:内疚感、回避-转移、角色保留和寻求支持、威胁控制努力、面对、恐惧和焦虑、角色浪费、成熟与成长、孤立和宿命。这些因素占观察到的方差的59.1%。进行Cronbach信度检验，计算10个因子的α值，范围为0.78 ~ 0.87，证实各因子内部一致。采用重测法对该天平的稳定性进行了测试。结论49项AIMI-IBC具有良好的心理测量特性。该工具使保健专业人员能够系统地评估伊朗乳腺癌妇女的应对策略，并衡量她们对疾病的适应程度。

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引用次数: 12

Evaluation of MAGE-1 Cancer-Testis Antigen Expression in Invasive Breast Cancer and its Correlation with Prognostic Factors 浸润性乳腺癌中MAGE-1癌睾丸抗原表达的评价及其与预后因素的相关性

Iranian journal of cancer prevention

Pub Date : 2016-08-01 DOI: 10.17795/ijcp-4404

Mojtaba Rastgoosalami, B. Memar, S. Aledavood, A. Fanipakdel

Background Aberrant expression of cancer-testis antigens (CTA) in breast carcinoma tissue, and its natural expression in the testis, the tissue away from the immune system, makes them good candidates for cancer immunotherapy and vaccines designing. Objectives The aim of this study was to assess the expression of a CTA (MAGE-1) in invasive breast cancer and its correlation with prognostic factors. Methods Paraffin blocks of breast cancer tissues from 113 patients operated in 2011 - 2013 were stained for MAGE-1expression by immunohistochemistry (IHC). The associations of MAGE-1 expression with known prognostic factors were assessed by statistical analysis using SPSS 16. Results MAGE-1 expression was found in cancer cell cytoplasms of 30.1% of patients, with different degrees of intensity, (23.9% moderate and 6.2% strong). Nuclear staining turned positive in 31.8%, stratified from moderate in 26.5%to to strong in 5.3%. There was a significant association between the number of lymph nodes involved and both nuclear (P = 0.042) and cytoplasmic (P = 0.003) MAGE-1 expression. There was also a significant correlation between the nuclear expression of MAGE-1 and tumor size (P = 0.018). Cytoplasmic expression of MAGE-1 increased with increasing pathologic grade of tumors although the association was not statistically significant (P = 0.119). Conclusions CTA MAGE-1 has significant association with some prognostic factors in breast cancer and may have the role of a prognostic factor.

肿瘤睾丸抗原(CTA)在乳腺癌组织中的异常表达及其在远离免疫系统的睾丸组织中的自然表达，使其成为癌症免疫治疗和疫苗设计的良好候选者。目的本研究的目的是评估CTA (MAGE-1)在浸润性乳腺癌中的表达及其与预后因素的相关性。方法采用免疫组化(IHC)方法对2011 - 2013年113例乳腺癌患者的组织石蜡块进行mage -1表达染色。使用SPSS 16进行统计分析，评估MAGE-1表达与已知预后因素的相关性。结果30.1%的患者癌细胞细胞质中存在不同程度的MAGE-1表达，其中中度表达23.9%，强烈表达6.2%。核染色变为阳性的占31.8%，从中度(26.5%)到强烈(5.3%)分层。淋巴结受累数与细胞核(P = 0.042)和细胞质(P = 0.003) MAGE-1表达均有显著相关性。MAGE-1的核表达与肿瘤大小也有显著相关性(P = 0.018)。MAGE-1的细胞质表达随肿瘤病理分级的增加而增加，但相关性无统计学意义(P = 0.119)。结论CTA MAGE-1与乳腺癌的一些预后因素有显著相关性，可能具有预后因素的作用。

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引用次数: 8

The Relationship Between Risk Factors and Survival in Adult Acute Lymphoblastic Leukemia 成人急性淋巴细胞白血病危险因素与生存的关系

Iranian journal of cancer prevention

Pub Date : 2016-08-01 DOI: 10.17795/ijcp-5045

A. Allahyari, S. Hashemi, F. Nazemian, M. Karimi, M. Kazemi, M. Sadeghi

Background Acute lymphoblastic leukemia (ALL) is aggressive cancer, especially in adults as only 20-40% is cured with current treatment regimens. Objectives The aim of this study is to evaluate prognostic factors and their effects on survival in ALL patients in the Northeast of Iran. Methods In a descriptive and retrospective study from 2009 to 2015, 48 ALL patients referred to hematology-oncology clinic. Age, sex, fever, blood group, type of ALL and consumption of amphotericin B, forms of cytogenetic, survival in the patients, WBC, hemoglobin, and platelet were checked in the first referral for every patient. The mean follow-up was 27.3 months in which 28 patients (59.3%) died. overall survival (OS) was plotted by GraphPad Prism 5 and the Log-rank test was used for analysis of survival with risk factors. Results The mean age for all the ALL patients at diagnosis was 32.3 years (range, 15-71 years), and 81.3% were male. Of all patients, 62.5% had fever and 25% consumed amphotericin B. 1-, 2-, 3-, 4-, 5-year OS rates were 62.2%, 52.7%, 40.6%, 39.1%, 22.2%, respectively. 75%, 29.2% and 39.6% of patients had WBC < 20 × 103/μl, Hb < 7 g/dL and platelet < 30 × 103/μL, respectively. There was a significant difference in survival based on age (P = 0.000). Conclusions Based on the results, age > 35 years is the most prognostic factor in ALL patients. Also, patients who received amphotericin B had lower life expectancy because these patients were suffering from fungal infection or due to lack of response to antibacterial drugs, they have been treated with amphotericin B.

急性淋巴细胞白血病(ALL)是一种侵袭性癌症，特别是在成人中，目前的治疗方案只有20-40%的治愈率。本研究的目的是评估伊朗东北部ALL患者的预后因素及其对生存的影响。方法对2009 - 2015年在血液学肿瘤学门诊就诊的48例ALL患者进行描述性和回顾性研究。年龄、性别、发烧、血型、ALL类型和两性霉素B的消耗、细胞遗传学形式、患者生存率、白细胞、血红蛋白和血小板在每个患者的第一次转诊时进行检查。平均随访27.3个月，其中28例(59.3%)死亡。采用GraphPad Prism 5绘制总生存率(OS)，采用Log-rank检验分析生存率与危险因素的关系。结果all患者诊断时平均年龄为32.3岁(15 ~ 71岁)，男性占81.3%。62.5%的患者有发热，25%的患者使用两性霉素b。1、2、3、4、5年总生存率分别为62.2%、52.7%、40.6%、39.1%、22.2%。WBC < 20 × 103/μl的占75%，Hb < 7 g/dL的占29.2%，血小板< 30 × 103/μl的占39.6%。不同年龄生存率差异有统计学意义(P = 0.000)。结论年龄0 ~ 35岁是影响ALL患者预后的最重要因素。此外，接受两性霉素B治疗的患者预期寿命较低，因为这些患者患有真菌感染或由于对抗菌药物缺乏反应，他们已经接受了两性霉素B治疗。

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引用次数: 5

Effects of Chrysin-PLGA-PEG Nanoparticles on Proliferation and Gene Expression of miRNAs in Gastric Cancer Cell Line 白杨素- plga - peg纳米颗粒对胃癌细胞增殖及mirna基因表达的影响

Iranian journal of cancer prevention

Pub Date : 2016-08-01 DOI: 10.17795/ijcp-4190

F. Mohammadian, A. Abhari, H. Dariushnejad, A. Nikanfar, Younes Pilehvar-Soltanahmadi, N. Zarghami

Background Recently, Chrysin, as a flavone, has revealed cancer chemo-preventive activity. The present experiment utilized the PLGA-PEG-chrysin complex, and free chrysin, to evaluation of the expression of miR-22, miR-34a and miR-126 in human gastric cell line. Objectives The purpose of this study was to examine whether nano encapsulating chrysin improves the anti-cancer effect of free chrysin on AGS human gastric cell line. Methods Properties of the chrysin encapsulated in PLGA-PEG nanoparticles were investigated by SEM, H NMR, and FTIR. The assessment of cytotoxicity on the growth of the human gastric cell line was carried out through MTT assay. After treating the cells with a prearranged amount of pure and encapsulated chrysin, RNA was extracted and the expressions of miR-22, miR-34a and miR-126 were measured by using real-time PCR. Results With regard to the amount of the chrysin loaded in PLGA-PEG nanoparticles, IC50 value was significantly decreased in nanocapsulatedchrysin, in comparison with free chrysin. This finding has been proved through the further increase of miR-22, miR-34a and miR-126 gene expression of nanocapsulatedchrysin, in comparison with free chrysin. Conclusions In this study, we revealed that the PLGA-PEG-chrysin is more effective than free chrysin in inhibiting the growth of human gastric cell line.

背景近年来，黄菊花素作为一种黄酮类化合物被发现具有肿瘤化学预防作用。本实验利用PLGA-PEG-chrysin复合物和游离chrysin来评价miR-22、miR-34a和miR-126在人胃细胞系中的表达。目的研究纳米包封金菊素是否能提高游离金菊素对AGS人胃癌细胞的抗癌作用。方法采用扫描电镜(SEM)、核磁共振(H NMR)、红外光谱(FTIR)等方法对聚乙二醇-聚乙二醇纳米颗粒包裹的杨菊素进行表征。采用MTT法对人胃细胞株生长进行了细胞毒性评价。用预先安排好的纯包膜的菊花素处理细胞后，提取RNA，用实时荧光定量PCR检测miR-22、miR-34a和miR-126的表达。结果在PLGA-PEG纳米颗粒的负载量下，纳米胶囊的IC50值与游离的相比显著降低。这一发现已经通过纳米胶囊化的白菊花素的miR-22, miR-34a和miR-126基因表达的进一步增加与游离白菊花素相比得到证实。结论在本研究中，我们发现PLGA-PEG-chrysin对人胃细胞系生长的抑制作用优于游离的chrysin。

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引用次数: 66

A Rare Presentation of Primary Nasopharyngeal Carcinoma (NPC) in Mediastinum 原发性鼻咽癌在纵隔的罕见表现

Iranian journal of cancer prevention

Pub Date : 2016-06-15 DOI: 10.17795/ijcp-4277

A. Fathi, F. Amani, M. Davoodi, S. Bahadoram, M. Bahadoram

Introduction Nasopharyngeal carcinoma among the children has been rare accounting for only 1% of all pediatric malignancies. Both genetic and environmental factors have contributed to the development of nasopharyngeal carcinoma. Among the children there was a higher rate of undifferentiated histology. The mean age of nasopharyngeal carcinoma diagnosis has been 11 years old age; and the most common site was nasopharynx. Palpable lymphadenopathy, dysphasia and neural defect were common associated signs. Case Presentation A 15-year-old boy has presented with a mass that located near by the heart in the left side of mediastinum with invasion to anterior mediastinum from two years ago. In biopsy, nasopharyngeal carcinoma, non-keratinizing type, has diagnosed while there was no involvement of nasopharyngeal region. Patient has treated by 70 Gy (2.0 Gy/fraction) radiotherapy plus concomitant chemotherapy with base of docetaxel. But the mass had no regression. Then, the patient has treated with Cisplatin 100 mg/m2 IV on days 1, 22, and 43 with radiation, then cisplatin 80 mg/m2 IV on day 1 plus fluorouracil (5-FU) 1000 mg/m2/day by continuous IV infusion on days 1 - 4 every 4wk for 3 cycles and after remission interferon beta has added to treatment for 6 months duration as a maintenance therapy. After 1 year follow up; the patient was in complete remission. In the course of therapy, only hypothyroidism has occurred. Conclusions Nasopharyngeal carcinoma in childhood, without nasopharyngeal involvement, initially could be detected in other sites such as pericardium. Also good results could be respected by cisplatin and 5-fluorouracil based neoadjuvant chemotherapy before radiotherapy plus interferon beta as a maintenance therapy in childhood aggressive nasopharyngeal carcinoma.

鼻咽癌在儿童中很少见，仅占所有儿童恶性肿瘤的1%。遗传和环境因素都是鼻咽癌发生的重要因素。在儿童中，未分化的组织学比例较高。鼻咽癌确诊的平均年龄为11岁;最常见的部位是鼻咽部。可触及的淋巴结病变、吞咽不良和神经缺损是常见的相关征象。病例介绍:一名15岁的男孩，两年前出现了位于心脏附近左侧纵隔的肿块，并侵犯了前纵隔。活检证实鼻咽癌为非角化型，未累及鼻咽区。患者接受70 Gy (2.0 Gy/分)放疗加多西紫杉醇基础化疗。但质量没有下降。然后，患者在第1、22、43天给予顺铂100mg /m2 IV放疗，第1天给予顺铂80mg /m2 IV加氟尿嘧啶(5-FU) 1000mg /m2/天连续静脉输注，第1 - 4天每4周持续静脉输注，持续3个周期，缓解后在治疗中加入干扰素β 6个月作为维持治疗。随访1年后;病人病情完全缓解。在治疗过程中，仅发生甲状腺功能减退。结论儿童鼻咽癌不累及鼻咽部，可在心包等其他部位发现。儿童侵袭性鼻咽癌放疗前以顺铂和5-氟尿嘧啶为基础的新辅助化疗加干扰素维持治疗也可获得良好的效果。

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引用次数: 1

Anti-Proliferative Activity of λ-Carrageenan Through the Induction of Apoptosis in Human Breast Cancer Cells λ-卡拉胶通过诱导人乳腺癌细胞凋亡的抗增殖活性

Iranian journal of cancer prevention

Pub Date : 2016-06-15 DOI: 10.17795/ijcp-3836

Marie Jazzara, A. Ghannam, Chadi Soukkarieh, Hossam Murad

Background Sulfated Polysaccharides (SPs) possess spectrum of pharmacological and therapeutic properties that could attributed to their origins variation, chemical structures and biological activities. Various studies have shown the impact of SPs on proliferation in different cancer cell lines. Objectives In this study, we have evaluated the biological effects of λ-carrageenan, a highly SP, extracted from the red seaweed Laurencia papillosa, on MDA-MB-231 cancer cell line. Materials and Methods MDA-MB-231 cells have treated with λ-carrageenan, the viability and apoptosis have assessed by the appropriate florescent probes on flow cytometer. The expression levels of mRNA of apoptotic genes have detected by real-time PCR analysis. Results Our results have indicated that the signaling pathway of λ-carrageenan inhibited the proliferation of MDA-MB-231 cells by up-regulating the pro-apoptotic genes caspase-8, caspase-9, caspase-3 which have been resulting the increased levels of active caspase-3 protein. Furthermore, This SP had that capacity to disrupt the mitochondrial function by altering the bax/bcl-2 ratio of expression which has considered an important element in apoptosis induction. Conclusions The presented results have signposted that λ-carrageenan was a promising bioactive polymer which could be a potential candidate in preventing or treating breast cancer.

硫酸酸化多糖(SPs)具有广泛的药理和治疗特性，这可能归因于其来源、变异、化学结构和生物活性。各种研究表明，SPs对不同癌细胞系的增殖有影响。目的研究从紫菜中提取的高SP含量的λ-卡拉胶对MDA-MB-231癌细胞的生物学作用。材料与方法用λ-卡拉胶处理MDA-MB-231细胞，在流式细胞仪上采用合适的荧光探针检测细胞活力和凋亡情况。实时荧光定量PCR检测凋亡基因mRNA表达水平。结果λ-卡拉胶信号通路通过上调促凋亡基因caspase-8、caspase-9、caspase-3抑制MDA-MB-231细胞的增殖，从而导致caspase-3活性蛋白水平升高。此外，该SP具有通过改变bax/bcl-2表达比例来破坏线粒体功能的能力，而bax/bcl-2表达比例被认为是诱导凋亡的重要因素。结论λ-卡拉胶是一种很有前途的生物活性聚合物，可能是预防或治疗乳腺癌的潜在候选物。

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引用次数: 18

Psychological Predictors of Prostate Cancer Screening Behaviors Among Men Over 50 Years of Age in Hamadan: Perceived Threat and Efficacy. 哈马丹 50 岁以上男性前列腺癌筛查行为的心理预测因素：感受到的威胁和有效性。

Iranian journal of cancer prevention

Pub Date : 2016-06-14 eCollection Date: 2016-08-01 DOI: 10.17795/ijcp-4144

Majid Barati, Mohammad Ali Amirzargar, Saeed Bashirian, Vahid Kafami, Amir Abbas Mousali, Babak Moeini

Background: Prostate cancer is the fourth most common cancer worldwide and is the second most lethal cancer.

Objectives: The aim of this study was to investigate psychological predictors of prostate cancer screening behaviors among men over 50 years of age in Hamadan.

Materials and methods: This cross-sectional study was carried out on 200 men over 50 years of age in Hamadan, west of Iran. Participants were recruited with a cluster sampling method. The subjects completed a self-administered questionnaire including demographic characteristics, prostate cancer screening behaviors and psychological factors related to prostate cancer. Data was analyzed by SPSS-18 using chi-square, fisher exact test, and logestic regression.

Results: According to the results, 8.5 and 7.5 percent of participants reported history of digital rectal exam and prostate-specific antigen test, respectively. Also, the subjects reported 18.5%, 49.3% and 50.3% of receivable scores of knowledge, perceived threat, and perceived efficacy of prostate cancer screening behaviors, respectively. There was a significant association between prostate cancer screening behaviors and age groups (P < 0.05).

Conclusions: The results showed that providing analytical studies in this field helps to surface the hidden aspects of this context and the health care providers and administrators will hopefully consider them in planning for identification of psychological factors, such as barriers and facilitators factors.

背景：前列腺癌是全球第四大常见癌症，也是第二大致命癌症：前列腺癌是全球第四大常见癌症，也是第二大致命癌症：本研究旨在调查哈马丹 50 岁以上男性前列腺癌筛查行为的心理预测因素：这项横断面研究以伊朗西部哈马丹市 200 名 50 岁以上男性为对象。研究采用集群抽样法招募受试者。受试者填写了一份自填问卷，内容包括人口统计学特征、前列腺癌筛查行为以及与前列腺癌相关的心理因素。数据使用 SPSS-18 进行分析，采用的方法包括卡方检验、渔夫精确检验和对数回归：结果显示，分别有 8.5% 和 7.5% 的受试者报告了数字直肠指检和前列腺特异性抗原检测史。此外，受试者在前列腺癌筛查行为的知识、感知威胁和感知效果方面的得分分别为 18.5%、49.3% 和 50.3%。前列腺癌筛查行为与年龄组之间存在明显关联（P < 0.05）：研究结果表明，在这一领域开展分析研究有助于揭示这一背景下的隐性问题，希望医疗服务提供者和管理者在规划识别心理因素（如障碍和促进因素）时考虑到这些因素。

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引用次数: 0

The Role of Psychological Hardiness and Marital Satisfaction in Predicting Posttraumatic Growth in a Sample of Women With Breast Cancer in Isfahan 心理适应度和婚姻满意度在预测伊斯法罕乳腺癌妇女创伤后成长中的作用

Iranian journal of cancer prevention

Pub Date : 2016-06-14 DOI: 10.17795/ijcp-4080

A. Aflakseir, S. Nowroozi, J. Mollazadeh, M. Goodarzi

Background Posttraumatic growth (PTG) refers to positive psychological change experienced as a result of the struggle with highly challenging life circumstances. PTG in cancer survivors is related to several psychosocial factors such as psychological hardiness and marital satisfaction. Objectives The purpose of this study was to examine the prediction of posttraumatic growth based on psychological hardiness and marital satisfaction. Patients and Methods A total of 120 women with breast cancer were recruited from several hospitals in Isfahan using convenience sampling. Participants completed the research questionnaires including the posttraumatic growth inventory (PTGI), the Ahvaz psychological hardiness scale and the Enrich’s marital satisfaction scale (EMS). Statistical analysis including means, standard deviation, Pearson’s correlation and multiple regression analysis were carried out using SPSS software (version 16). Results Results indicated that the majority of patients with cancer experienced posttraumatic growth. Findings also showed that psychological hardiness, marital satisfaction and longer time since diagnosis of cancer significantly predicted posttraumatic growth. Conclusions This study highlights the significant role of psychological hardiness and marital support in personal growth of breast cancer survivors.

创伤后成长(PTG)指的是由于与极具挑战性的生活环境作斗争而经历的积极的心理变化。癌症幸存者的PTG与心理适应力、婚姻满意度等心理因素有关。目的探讨心理适应度和婚姻满意度对创伤后成长的预测。患者与方法采用方便抽样方法，从伊斯法罕多家医院招募120名乳腺癌患者。研究对象完成创伤后成长量表(PTGI)、阿瓦兹心理适应度量表(Ahvaz psychological hardy scale)和富氏婚姻满意度量表(Enrich’s marriage satisfaction scale)。统计分析采用SPSS软件(version 16)进行，包括均值、标准差、Pearson相关和多元回归分析。结果绝大多数癌症患者均经历创伤后生长。研究结果还显示，心理韧性、婚姻满意度和癌症诊断后较长的时间对创伤后生长有显著的预测作用。结论心理韧性和婚姻支持对乳腺癌幸存者的个人成长有重要影响。

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引用次数: 25

Adenosine Deaminase Activity in Chronic Lymphocytic Leukemia and Healthy Subjects. 慢性淋巴细胞白血病和健康受试者的腺苷脱氨酶活性

Iranian journal of cancer prevention

Pub Date : 2016-06-13 eCollection Date: 2016-06-01 DOI: 10.17795/ijcp-5069

Bayazid Ghaderi, Sabrieh Amini, Farzad Maroofi, Chiya Jalali, Mitra Javanmardi, Daem Roshani, Mohammad Abdi

Background: B cell chronic lymphocytic leukemia is one of the most frequent hematologic malignancies in the world. Cellular surface CD markers and serum Beta-2-microglobulin may be used as a prognostic tool in CLL patients.

Objectives: In the present study we introduce serum adenosine deaminase as a diagnostic marker in CLL.

Materials and methods: Blood samples were collected from B-CLL and healthy subjects. White blood cell, red blood cell and platelet count and blood Erythrocyte sedimentation rate was recorded and serum Beta-2-microglobulin, Lactate dehydrogenase and total ADA enzyme activity were determined.

Results: Serum ADA activity was significantly higher in patients group than that of controls. ADA had a significant and direct correlation with B2M, WBC, LDH and ESR. However, there was not any relation between ADA and the stages of disease. Diagnostic cut-off, sensitivity and specificity of the serum ADA test were 27.97 U/L, 91% and 94%, respectively.

Conclusions: A higher ADA activity in patients group and its correlation with CLL markers were seen in our study. High diagnostic value of serum ADA in our study suggests that it might be considered as a useful screening tool among the other markers in CLL.

背景：B细胞慢性淋巴细胞白血病是世界上最常见的血液系统恶性肿瘤之一。细胞表面CD标记物和血清β-2-微球蛋白可作为CLL患者的预后工具：在本研究中，我们将血清腺苷脱氨酶作为 CLL 的诊断指标：采集B-CLL和健康受试者的血样。记录白细胞、红细胞、血小板计数和红细胞沉降率，测定血清β-2-微球蛋白、乳酸脱氢酶和总 ADA 酶活性：结果：患者组的血清 ADA 活性明显高于对照组。ADA 与 B2M、WBC、LDH 和 ESR 有明显的直接相关性。但 ADA 与疾病的分期没有任何关系。血清 ADA 检测的诊断临界值、敏感性和特异性分别为 27.97 U/L、91% 和 94%：我们的研究发现，患者组的 ADA 活性较高，且与 CLL 标志物相关。在我们的研究中，血清 ADA 具有很高的诊断价值，这表明它可被视为 CLL 其他标志物中的一种有用的筛查工具。

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引用次数: 0

Central Nervous System Toxoplasmosis in Relapsed Hodgkin's Lymphoma: A Case Report. 复发霍奇金淋巴瘤中的中枢神经系统弓形虫病：病例报告。

Iranian journal of cancer prevention

Pub Date : 2016-06-11 eCollection Date: 2016-08-01 DOI: 10.17795/ijcp-5810

Hassan Abolghasemi, Ehsan Shahverdi, Ramezan Jafari, Fardin Dolatimehr, Azam Khandani

Introduction: Patients with immunosuppression have an increased incidence of toxoplasmosis characterized by involvement of the central nervous system. Only a few cases of toxoplasmosis associated with immunosuppressive agents have been reported. Such cases have been reported in immune suppressed patients outside the Iran, but a search of the literature has not revealed any previous reports from this country.

Case presentation: We described a 17- year -old male, a known case of Hodgkin's lymphoma with the diagnosis of central nervous system (CNS) toxoplasmosis.

Conclusions: As a conclusion, CNS toxoplasmosis should be considered in the differential diagnosis of immunosuppressed patients who present with neurological manifestations.

导言：免疫抑制患者弓形虫病的发病率增加，其特点是中枢神经系统受累。与免疫抑制剂相关的弓形虫病病例仅有少数报道。伊朗以外的国家也曾报道过免疫抑制患者感染弓形虫病的病例，但在文献检索中没有发现任何来自伊朗的报道：病例介绍：我们描述了一名 17 岁的男性患者，他患有霍奇金淋巴瘤，被诊断为中枢神经系统（CNS）弓形虫病：结论：中枢神经系统弓形虫病应在出现神经系统表现的免疫抑制患者的鉴别诊断中予以考虑。

引用次数: 0