Iranian journal of cancer prevention最新文献_第8页

Immunohistochemistry Study of P53 and C-erbB-2 Expression in Trophoblastic Tissue and Their Predictive Values in Diagnosing Malignant Progression of Simple Molar Pregnancy 滋养层组织中P53和C-erbB-2表达的免疫组化研究及其对单纯性磨牙妊娠恶性进展的预测价值

Iranian journal of cancer prevention

Pub Date : 2016-06-01 DOI: 10.17795/ijcp-4115

M. Hasanzadeh, N. Sharifi, M. Farazestanian, Seyed Saman Nazemian, Faezeh Madani Sani

Background Finding a tumor marker to predict the aggressive behavior of molar pregnancy in early stages has yet been a topic for studies. Objectives In this survey we planned to study patients with molar pregnancy to 1) assess the p53 and c-erbB-2 expression in trophoblastic tissue, 2) to study the relationship between their expression intensity and progression of a molar pregnancy to gestational trophoblastic neoplasia, and 3) to determine a cut off value for the amount of p53 and c-erbB-2 expression which might correlate with aggressive behavior of molar pregnancy. Patients and Methods In a prospective cross sectional study by using a high accuracy technique EnVision Tm system for immunohistochemistry staining of molar pregnancy samples, we evaluated p53 and c-erbB-2 expression in cytotrophoblast and syncytiotrophoblast and the correlation of their expression with progression of molar pregnancy to gestational trophoblastic neoplasia (GTN). Normal prostatic tissue and Breast cancer tissue were used as positive controls. Results We studied 28 patients with simple molar pregnancy (SMP) and 30 with GTN. Cytotrophobalst had significantly higher expression of p53 and c-erbB-2 and syncytiotrophoblast had greater expression of p53 in GTN group as compared to SMP group. The cut off values for percentage of p53 positive immunostained cytotrophoblast and syncytiotrophoblast were 5.5% and 2.5%. In c-erbB-2 positive membranous stained cytotrophoblast the cut off was 12.5%. Conclusions Our data suggests that over expression of p53 and c-erbB-2 is associated with malignant progression of molar pregnancy. We encountered that high expression of p53 and c-erbB-2 in trophoblastic cells could predict gestational trophoblastic neoplasia during the early stages.

寻找一种肿瘤标志物来预测早期磨牙妊娠的攻击行为一直是研究的课题。本研究拟对磨牙妊娠患者进行研究，目的:1)评估滋养层组织中p53和c-erbB-2的表达，2)研究其表达强度与磨牙妊娠至妊娠滋养层瘤变的关系，3)确定p53和c-erbB-2表达量的临界值，该临界值可能与磨牙妊娠的攻击行为相关。在一项前瞻性横切面研究中，我们使用高精度的EnVision Tm系统对磨牙妊娠样本进行免疫组织化学染色，评估了p53和c-erbB-2在细胞滋养细胞和合胞滋养细胞中的表达，以及它们的表达与磨牙妊娠到妊娠滋养细胞瘤(GTN)进展的相关性。正常前列腺组织和乳腺癌组织作为阳性对照。结果单纯磨牙妊娠(SMP) 28例，GTN 30例。GTN组细胞滋养层中p53和c-erbB-2的表达明显高于SMP组，合胞滋养层中p53的表达明显高于SMP组。免疫染色的细胞滋养层细胞和合胞滋养层细胞中p53阳性百分比的切断值分别为5.5%和2.5%。在c-erbB-2阳性膜染色的细胞滋养细胞中，切断率为12.5%。结论:p53和c-erbB-2的过表达与磨牙妊娠的恶性进展有关。我们发现滋养细胞中p53和c-erbB-2的高表达可以预测早期妊娠滋养细胞瘤的发生。

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引用次数: 4

CT Simulation to Evaluate of Pelvic Lymph Node Coverage in Conventional Radiotherapy Fields Based on Bone and Vessels Landmarks in Prostate Cancer Patients 基于骨和血管标志的前列腺癌患者常规放疗场盆腔淋巴结覆盖的CT模拟评估

Iranian journal of cancer prevention

Pub Date : 2016-06-01 DOI: 10.17795/ijcp-6233

Amir Shahram Yousefi Kashi, Samira Khaledi, M. Houshyari

Background Radiotherapy is the gold standard for treatment of prostrate cancer as it can cover an adequate area of tissues at risk for metastasis. Objectives We evaluated the Pelvic lymph node coverage of conventional radiotherapy fields based on bone and vessels landmarks using computed tomography (CT) simulation in patients with prostate cancer referred to Shohada-e-Tajrish hospital. Patients and Methods In this cross sectional study, 40 patients with prostate cancer at the Stage T1c to T3b were studied. Pelvic lymph nodes were contoured by using pelvic vessels as surrogate markers. The distances were measured at different points of anterior-posterior (AP) and lateral fields and distances > 5 mm or more between the contoured nodes and the field borders. Results Mean and standard deviation of the aortic bifurcation from the superior border was 4.73 ± 1.16 cm, the distance of common iliac bifurcation from the superior border was 1.11 ± 1.25 cm, the mean (SD) distance of right external iliac from the lateral border of AP field was 2.06 ± 0.48 cm and for left external iliac artery was 1.90 ± 0.56 cm. The distance of the external iliac artery from the anterior border of the lateral field was 2.30 ± 0.74 cm. The distance of the external iliac artery from pelvic rim was 0.59 ± 0.59 cm, distance of bifurcation of iliac from sacroiliac joint was 0.82 ± 1.01 cm, the size of the pelvic rim was 12.30 ± 0.64 cm, sacral width was 8.29 ± 1.01 cm, anterior promontory symphysis distance was 12.02 ± 0.92 cm and posterior promontory symphysis distance was 10.98 ± 0.73 cm. Conclusions We observed that conventional radiotherapy using CT simulation based on bone and vessels landmarks provided adequate coverage of pelvic lymph nodes in our patients with prostate cancer.

放疗是治疗前列腺癌的金标准，因为它可以覆盖有转移风险的组织的足够面积。目的:对在Shohada-e-Tajrish医院就诊的前列腺癌患者进行基于骨和血管地标的计算机断层扫描(CT)模拟，评估常规放疗场对盆腔淋巴结的覆盖。在这项横断面研究中，研究了40例T1c至T3b期前列腺癌患者。用盆腔血管作为替代标记物对盆腔淋巴结进行轮廓化。测量前后野野和侧野野不同点的距离，以及轮廓淋巴结与野野边界之间的距离bbb50 mm或更大。结果主动脉分叉距上缘的均值和标准差为4.73±1.16 cm，髂总分叉距上缘的均值和标准差为1.11±1.25 cm，右侧髂外动脉距AP野外侧缘的均值(SD)为2.06±0.48 cm，左侧髂外动脉距AP野外侧缘的均值(SD)为1.90±0.56 cm。髂外动脉距外侧野前缘距离2.30±0.74 cm。髂外动脉距骨盆缘0.59±0.59 cm，髂分叉距骶髂关节0.82±1.01 cm，骨盆缘大小12.30±0.64 cm，骶骨宽度8.29±1.01 cm，前岬联合距离12.02±0.92 cm，后岬联合距离10.98±0.73 cm。结论:我们观察到，基于骨和血管标志的CT模拟常规放疗可以充分覆盖前列腺癌患者的盆腔淋巴结。

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引用次数: 12

Lactobacilli Differentially Modulate mTOR and Wnt/ β-Catenin Pathways in Different Cancer Cell Lines 乳酸菌对不同癌细胞mTOR和Wnt/ β-Catenin通路的差异调节

Iranian journal of cancer prevention

Pub Date : 2016-06-01 DOI: 10.17795/ijcp-5369

Z. Taherian-Esfahani, A. Abedin-Do, Z. Nouri, R. Mirfakhraie, S. Ghafouri-Fard, E. Motevaseli

Background Lactobacilli are a group of beneficial bacteria whose anti cancer effects have been evaluated in different cancer cell lines as well as animal models and human subjects. Such anti cancer effects can be exerted via different mechanisms such as modulation of immune response as well as inhibition of pathogens colonization. In addition, lactobacilli have direct cytotoxic effects against cancer cells which may be exerted through modulation of expression cancer related pathways. Objectives The aim of this study is to find the mechanism of anti cancer effects of two lactobacilli strains, Lactobacillus. crispatus (LC) and Lactobacillus. rhamnosus (LR). Materials and Methods We analyzed expression of some mTOR and Wnt/ β-catenin pathways genes in three cancer cell lines (HeLa, MDA-MB-231 and HT-29) following treatment with LC and LR culture supernatants. Results Of note, the expression of CCND1 as a marker of cell proliferation, survival, and angiogenesis, has been decreased following LR treatment in all cell lines. In addition, the expression of SFRP2, an antagonist of Wnt pathway, has been increased in HT-29 following LR treatment and in HeLa cells following LR and LC treatments. Furthermore, we have demonstrated the downregulation of S6K1 expression, a marker of poor prognosis, following LR treatment in HT-29 and following LR and LC treatments in MDA-MB-231 cell line. Conclusions Consequently, lactobacilli can modulate expression of mTOR and Wnt/ β-catenin pathways genes in cancer cell lines in a strain specific as well as cell type specific manner.

乳酸菌是一类有益细菌，其抗癌作用已在不同的癌细胞系、动物模型和人体中得到了评价。这种抗癌作用可以通过不同的机制发挥作用，如调节免疫反应和抑制病原体定植。此外，乳酸菌对癌细胞具有直接的细胞毒作用，可能通过调节肿瘤相关通路的表达来发挥作用。目的探讨两株乳酸菌的抗癌作用机制。crispatus (LC)和乳酸菌。喂食(LR)。材料和方法我们分析了三种癌细胞(HeLa、MDA-MB-231和HT-29)在LC和LR培养上清处理后mTOR和Wnt/ β-catenin通路部分基因的表达情况。值得注意的是，CCND1的表达作为细胞增殖、存活和血管生成的标志，在LR治疗后，在所有细胞系中都有所下降。此外，在LR处理后的HT-29以及LR和LC处理后的HeLa细胞中，Wnt通路拮抗剂SFRP2的表达增加。此外，我们已经证明，在HT-29和MDA-MB-231细胞系中，LR和LC治疗后，S6K1表达下调，这是预后不良的标志。结论乳酸菌对癌细胞mTOR和Wnt/ β-catenin通路基因的表达具有菌株特异性和细胞类型特异性。

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引用次数: 36

Stevens-Johnson Syndrome Patient Received Combination Chemotherapy Gemcitabine, Cisplatin, and 5-FU for Biliary Tract Cancer 史蒂文斯-约翰逊综合征患者接受吉西他滨、顺铂和5-FU联合化疗治疗胆道癌

Iranian journal of cancer prevention

Pub Date : 2016-06-01 DOI: 10.17795/ijcp-4211

M. Aznab, M. Khazaei

Stevens-Johnson syndrome has been an acute, usually self-limiting disease of the skin and mucous membranes. This case report has presented an evidence of the development Stevens - Johnson syndrome associated with combination chemotherapy administration of 5FU, gemcitabin and cisplatin in a patient with biliary tract cancer. Our case was a 54-year-old woman patient, a case of biliary tract cancer who has developed more severe symptoms of Stevens-Johnson syndrome. Diagnosis has confirmed by skin biopsy of an affected area .The patient has improved with supportive care, and during 25 day occurred recovery. Although Stevens-Johnson syndrome has been a rare toxicity, physicians should pay a special attention to the monitoring of biliary tract cancer patients on combination chemotherapy with 5FU, cisplatin and gemcitabin.

史蒂文斯-约翰逊综合征是一种急性的，通常是自限性的皮肤和粘膜疾病。本病例报告提出了一个胆道癌患者联合化疗给予5FU、吉西他滨和顺铂相关的史蒂文斯-约翰逊综合征的证据。我们的病例是一名54岁的女性患者，她是胆道癌患者，并发了更严重的史蒂文斯-约翰逊综合征。经患处皮肤活检确诊。患者在支持性护理下病情好转，25天内恢复。虽然史蒂文斯-约翰逊综合征是一种罕见的毒性，但医生应特别注意5FU、顺铂和吉西他滨联合化疗的胆道肿瘤患者的监测。

引用次数: 3

Rhabdomyosarcoma of Cervix: A Case Report 子宫颈横纹肌肉瘤1例报告

Iranian journal of cancer prevention

Pub Date : 2016-06-01 DOI: 10.17795/ijcp-4383

M. Hosseini, T. Ashrafganjoei, A. Sourati, Morteza Tabatabeifar, Mahdiss Mohamadianamiri

Introduction Rhabdomyosarcoma has known as a highly malignant soft tissue sarcoma. It has been the most common soft tissue sarcoma in childhood, accounting for about 3 to 4 % of all cases of childhood cancer. Rhabdomyosarcoma was rare in adults, accounting for 3% of all soft-tissue sarcomas. embryonal rhabdomyosarcoma of female genital tract including uterine cervix in an adult was rare. Case Presentation This study has reported a 33-year-old woman presented with abnormal vaginal discharge. Gynecologic examination revealed a cervical mass with grape- like feature protruding into vagina with posterior- superior vaginal wall involvement. Biopsy has performed and pathologic examination was consistent with embryonal botryoid type rhabdomyosarcoma. She has undergone the staging work up measurements including thoracic computed tomography (CT) scan, abdominopelvic magnetic resonance imaging (MRI), bone scan and bone marrow examination. In exception of abdominopelvic MRI, with 2 suspicious pelvic lymph nodes in addition of cervical mass, all others were normal. Radical hysterectomy with lymph node debulking and ovarian preservation has performed. Final results have shown embryonal botryoid type rhabdomyosarcoma of cervix. ovaries, endometrium, parametrium, and follopian tubes were unremarkable. Pelvic lymph nodes pathology and intraabdominal fluid cytology were negative for malignancy. Lymphovascular invasion was identified. She has advised for adjuvant chemotherapy. Conclusions This case has reminded that embryonal rhabdomyosarcoma could occur in uncommon site and older female. Longer follow up of these cases has required due to lack of survival data for embryonal rhabdomyosarcoma of this site and age group.

横纹肌肉瘤是一种高度恶性的软组织肉瘤。它是儿童时期最常见的软组织肉瘤，约占所有儿童癌症病例的3%至4%。横纹肌肉瘤在成人中很少见，占所有软组织肉瘤的3%。摘要胚胎性横纹肌肉瘤发生于女性生殖道，包括子宫颈，实属罕见。本研究报告了一位33岁的女性表现为阴道分泌物异常。妇科检查发现一葡萄样宫颈肿块，突出于阴道内，并累及阴道后上壁。活检和病理检查符合胚胎性骨样横纹肌肉瘤。她接受了分期工作的测量，包括胸部计算机断层扫描(CT)，腹部骨盆磁共振成像(MRI)，骨骼扫描和骨髓检查。除腹部骨盆MRI发现2个可疑盆腔淋巴结及宫颈肿块外，其余均正常。根治性子宫切除术伴淋巴结肿大和卵巢保存。最后的结果显示子宫颈胚胎性骨样横纹肌肉瘤。卵巢、子宫内膜、子宫参数和输卵管未见明显变化。盆腔淋巴结病理及腹内液细胞学均为阴性。发现淋巴血管浸润。她被建议进行辅助化疗。结论本病例提示胚胎性横纹肌肉瘤可发生于罕见部位和老年女性。由于缺乏该部位和年龄组的胚胎横纹肌肉瘤的生存数据，需要对这些病例进行更长的随访。

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引用次数: 6

The Prognostic Value of Age, Sex, and Subsite in Cutaneous Head and Neck Melanoma: A Clinical Review of Recent Literature 皮肤头颈部黑色素瘤的年龄、性别和亚位的预后价值:近期文献的临床回顾

Iranian journal of cancer prevention

Pub Date : 2016-06-01 DOI: 10.17795/ijcp-5079

Sameep P. Kadakia, D. Chan, Moustafa W Mourad, Y. Ducic

Context Cutaneous head and neck melanoma is a challenging disease owing to its aggressive nature and often times advanced stage at presentation. Age, sex, and subsite are three prognostic indicators which can be determined prior to treatment or testing, and can allow the practitioner to counsel the patient before initiating therapy. Evidence Acquisition A PubMed search was conducted utilizing various terms relating to the subject matter. Articles over the past 25 years were analyzed and appropriately selected for review. Results It appears that patients older than 65 have a decreased overall 5 year survival compared to their younger counterparts. Male patients have poorer prognosis compared to female patients as noted by the decreased overall survival, decreased disease specific survival, and shorter time to distant metastasis. Scalp subsite was most uniformly accepted as having the worst prognosis in the head and neck, and may even serve as an independent prognostic indicator. Conclusions Advanced age, male sex, and scalp subsite all portend poor prognosis in patients with cutaneous head and neck melanoma.

皮肤头颈部黑色素瘤是一种具有挑战性的疾病，因为它具有侵袭性，并且经常在发病时处于晚期。年龄、性别和亚部位是三个预后指标，可以在治疗或检测前确定，并允许医生在开始治疗前向患者提供咨询。利用与主题相关的各种术语进行PubMed搜索。对过去25年的文章进行分析，并适当选择进行审查。结果65岁以上的患者与年轻患者相比，总体5年生存率降低。与女性患者相比，男性患者的预后较差，表现为总生存期降低，疾病特异性生存期降低，远端转移时间缩短。头皮亚位点被普遍认为是头颈部预后最差的亚位点，甚至可以作为一个独立的预后指标。结论老年、男性、头皮亚位均预示皮肤头颈部黑色素瘤患者预后不良。

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引用次数: 12

Cancer Screening, Effective or Harmful? 癌症筛查有效还是有害?

Iranian journal of cancer prevention

Pub Date : 2016-06-01 DOI: 10.17795/ijcp-7616

Mohammad Esmaeil Akbari

Once a widely accepted notion, mammography screening is now called into doubt, in some cases rendered unjustifiable, by studies in developed countries. In spite of the fact that screening cannot prove to be effective may seem meaningless at the first glance, in practice, the procedures and strategies are to be reconstructed. In Iran, for instance, 40% of diagnosed breast cancer in women are locally developed or metastatic. The main issues for screening such cancers are primary tumor size, axillary nodal status down staging strategy, and screening programs. In fact, by cancer early detection we will be needless of the high technology of the developed world, while we lack the infrastructure and resources to use the technology appropriately to achieve adequate coverage of the population. In our previous studies, we found that tumor size and nodal status are the most frequent symptoms for referring to clinics, also we concluded that screening mammography in many countries would not be beneficial. Although effective in the first round for detection of about 53% of the cancer cases, provided the equipment is readily available throughout the country, it is far less efficient in the second and third rounds which spells an ineffective strategy. Therefore, a shift in strategies seems essential for health decision makers especially in countries including Iran.

乳房x光检查曾经是一种被广泛接受的观念，现在却受到了发达国家研究的质疑，在某些情况下被认为是不合理的。尽管乍一看，筛检不能证明是有效的，似乎毫无意义，但在实践中，程序和策略是要重建的。例如，在伊朗，确诊的女性乳腺癌中有40%是局部发展或转移的。筛查此类癌症的主要问题是原发肿瘤大小、腋窝淋巴结状态、分期策略和筛查方案。事实上，通过癌症的早期检测，我们将不需要发达国家的高科技，而我们缺乏基础设施和资源，无法适当地使用这些技术来实现人口的充分覆盖。在我们之前的研究中，我们发现肿瘤大小和淋巴结状态是就诊最常见的症状，我们也得出结论，在许多国家筛查乳房x光检查并没有好处。虽然在第一轮检测中对约53%的癌症病例有效，但如果设备在全国各地都能随时获得，它在第二轮和第三轮的效率要低得多，这意味着一种无效的战略。因此，战略的转变似乎对卫生决策者至关重要，特别是在包括伊朗在内的国家。

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引用次数: 0

Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and Obesity 瘦素和瘦素受体的遗传变异与结直肠癌和肥胖的易感性

Iranian journal of cancer prevention

Pub Date : 2016-06-01 DOI: 10.17795/ijcp-7013

T. Mahmoudi, H. Farahani, H. Nobakht, R. Dabiri, M. Zali

Background Colorectal cancer (CRC) is the second most commonly diagnosed cancer and the fourth leading cause of cancer-related mortality around the world. Objectives With regard to the role of obesity in colorectal cancer (CRC) and the role of leptin in obesity, we investigated whether leptin (LEP) and leptin receptor (LEPR) gene variants are associated with CRC risk. Patients and Methods We evaluated LEP (rs7799039) and LEPR (rs1137101) gene variants by using PCR-RFLP method in 261 cases with CRC and 339 controls. Results No significant difference was found for rs7799039 and rs1137101gene variants between the cases with CRC and controls. However, the LEPR rs1137101 “GG” genotype compared with “AA” genotype and “AA + AG” genotype was associated with increased risks for obesity, and the differences remained significant after adjustment for confounding factors including age, sex, smoking status, and NSAID use (P = 0.015; OR = 2.42, 95%CI = 1.19 - 4.93 and P = 0.016; OR = 2.28, 95%CI = 1.17 - 4.48, respectively). In addition, the LEPR “G” allele compared with the “A” allele was associated with an increased risk for obesity (P = 0.024; OR = 1.44, 95%CI = 1.05 - 1.98). Conclusions Consistent with most previous studies, our findings found no association between LEP (rs7799039) and LEPR (rs1137101) gene variants and CRC risk. However, the LEPR rs1137101 “GG” genotype compared with the “AA” genotype and “AA+AG” genotype was associated with a 2.42-fold and a 2.28-fold increased risk for obesity, respectively.

结直肠癌(CRC)是世界上第二大最常诊断的癌症，也是第四大癌症相关死亡原因。针对肥胖在结直肠癌(CRC)中的作用以及瘦素在肥胖中的作用，我们研究了瘦素(LEP)和瘦素受体(LEPR)基因变异是否与结直肠癌风险相关。采用PCR-RFLP方法对261例结直肠癌患者和339例对照组的LEP (rs7799039)和LEPR (rs1137101)基因变异进行了分析。结果CRC患者与对照组rs7799039和rs1137101基因变异无显著性差异。然而，与“AA”基因型和“AA + AG”基因型相比，LEPR rs1137101“GG”基因型与肥胖风险增加相关，在校正了年龄、性别、吸烟状况和使用非甾体抗炎药等混杂因素后，差异仍然显著(P = 0.015;OR = 2.42, 95%CI = 1.19 ~ 4.93, P = 0.016;OR = 2.28, 95%CI = 1.17 ~ 4.48)。此外，与“A”等位基因相比，LEPR“G”等位基因与肥胖风险增加相关(P = 0.024;Or = 1.44, 95%ci = 1.05 - 1.98)。结论与大多数先前的研究一致，我们的研究发现LEP (rs7799039)和LEPR (rs1137101)基因变异与结直肠癌风险之间没有关联。然而，与“AA”基因型和“AA+AG”基因型相比，LEPR rs1137101“GG”基因型与肥胖风险分别增加2.42倍和2.28倍相关。

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引用次数: 14

Cancer Screening, Effective or Harmful? 癌症筛查有效还是有害?

Iranian journal of cancer prevention

Pub Date : 2016-04-27 eCollection Date: 2016-04-01 DOI: 10.17795/ijcp-6633

Mohammad Esmaeil Akbari

Cancer screening is a signal protocol created by health manpower to save lives due to prevention of cancer establishment or early detection with better prognosis. During the recent decade, some doubt have been casted and fact have risen to inhibit classic screening and introduce same new procedure instead of them. The most popular cancer in screening procedures is breast cancer. Obviously, mammography screening has saved many lives and has changed the clinical feature from locally advance to early stages. Comparing the trends of clinical staging of breast cancer before and after national screening program has confirmed this idea.In addition, recently, many researches have focused on the harm of mammography screening for example, the 2016, 352: bmj h 6967 reported that the harms of mammography screening outweigh its benefits. The member of cancer who died from breast cancer and other malignancies are not significantly different but the number of false diagnosis, harmful treatment, and the member of over treatment from non-progressive malignancies are significantly higher in the screening group. Here, I try to say something different about the benefits or harms of screening. Sometimes the definition of screening and its goal should be changed, for example in developing countries some kind of screening for breast cancer maybe efficient which are different from well- known mammography screening. In Iran about 40% of breast cancer cases are locally advanced as metastatic. Many of these cases are related to primary tumor size. Changing the community knowledge and health crew expertise will change this feature, and early stages with easier treatments and better prognosis will appear. Of course the subject of time will remain a challenging issue. We will discuss more in the next issue.

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引用次数: 3

The Islamic Perspective of Spiritual Intervention Effectiveness on Bio-Psychological Health Displayed by Gene Expression in Breast Cancer Patients. 从基因表达看伊斯兰教对乳腺癌患者生物心理健康的精神干预效果

Iranian journal of cancer prevention

Pub Date : 2016-04-27 eCollection Date: 2016-04-01 DOI: 10.17795/ijcp-6360

Leili Hosseini, Farah Lotfi Kashani, Somayeh Akbari, Mohammad Esmaeil Akbari, Saeedeh Sarafraz Mehr

Background: During the last two decades, there have been spiritual/religious interventions in cancer patients to prevent or treat a range of physical problems, including managing chronic pain, coping with the disease, boosting hope and mental health. Although societies are of different faiths and belief systems, what they all share is spirituality.

Objectives: Upon this we put forward the hypothesis of changes in gene receptor expressions as a result of spiritual intervention for the first time in the world.

Materials and methods: In this study, the spiritual intervention was conducted on 57 volunteer females with early breast cancer involvement. Blood samples were collected prior to and after the spiritual intervention to analyze the changes in dopamine gene receptor expressions as the main site of effect. In order to administer the spiritual intervention backed by Quran, Islam and international standards, issues, with emphasis on peace, human growth and perfection, accepting God as an eternal source of power and kindness to build trust and reduce stress, were selected. They included prayer, patience, reliance, self-sacrifice and forgiveness, altruism and kindness, remission and repentance, thankfulness, zikr (mantra), meditation, and death concept.

Results: Obtained results from peripheral blood mononuclear cell samples analyzed by real time-PCR showed significant reduction in dopamine gene receptor (DRD1-5) expressions in comparison with those of pre-test scores and the control group.

Conclusions: Spiritual intervention based on Islamic principals can bring back mental health, increase hope and quality of life and eventually change dopamine gene receptor expressions resulting in reduction of cell proliferation, thus better prevention and management in breast cancer patients compared to other forms of treatment.

背景:在过去的二十年中，对癌症患者进行了精神/宗教干预，以预防或治疗一系列身体问题，包括控制慢性疼痛，应对疾病，增强希望和心理健康。虽然社会有不同的信仰和信仰体系，但他们都有共同的灵性。目的:在此基础上，我们在世界上首次提出了精神干预导致基因受体表达变化的假说。材料与方法:本研究对57名参与早期乳腺癌的女性志愿者进行精神干预。在精神干预前后采集血液样本，分析多巴胺基因受体表达的变化作为主要影响部位。为了管理《古兰经》、伊斯兰教和国际标准所支持的精神干预，我们选择了一些问题，强调和平、人类的成长和完善，接受上帝是永恒的力量和仁慈的源泉，以建立信任和减轻压力。它们包括祈祷、耐心、依赖、自我牺牲和宽恕、利他主义和善良、宽恕和忏悔、感恩、zikr(咒语)、冥想和死亡概念。结果:real - time-PCR检测外周血单个核细胞样本结果显示，与前测组和对照组相比，多巴胺基因受体(DRD1-5)表达明显降低。结论:基于伊斯兰教义的精神干预可以使乳腺癌患者恢复心理健康，增加希望和生活质量，最终改变多巴胺基因受体表达，减少细胞增殖，从而比其他形式的治疗更好地预防和管理乳腺癌患者。

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引用次数: 23