Basic purpose of this survey studies was to check awareness level about color blindness among university students. Color blindness is color vision deficiency (CVD), which occurs due to genetic disorder in specialized cell of eye. Patients suffering with color blindness are unable to differentiate between certain colors like red, green and blue. Red-green deficiency is common among all patients. A questionnaire was prepared to estimate awareness of university students about color blindness. It is concluded from this survey studies that mostly students are unaware about etiology and recent treatments of color blindness.
{"title":"Awareness about Color Blindness among University Student","authors":"","doi":"10.33140/jcei.04.01.07","DOIUrl":"https://doi.org/10.33140/jcei.04.01.07","url":null,"abstract":"Basic purpose of this survey studies was to check awareness level about color blindness among university students. Color blindness is color vision deficiency (CVD), which occurs due to genetic disorder in specialized cell of eye. Patients suffering with color blindness are unable to differentiate between certain colors like red, green and blue. Red-green deficiency is common among all patients. A questionnaire was prepared to estimate awareness of university students about color blindness. It is concluded from this survey studies that mostly students are unaware about etiology and recent treatments of color blindness.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82218317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective of the present study was to compare any relationship between normal blood pressure and body weight. Normal blood pressure is very crucial for our life. Blood pressure is important because it provides oxygen and nutrients to our tissues and organs, this pressure cause the blood to flow throughout the body via arteries. Blood pressure is developed when our heart pumps the blood on contraction with heart beats. Body weight of human is measured in kilograms. Body weight fluctuation occurs due to the water amount in our body. There are many methods to access the body weight like dual-energy X-ray absorptiometry and the percentage of muscles, fats and bones in a human body. We used an instrument known as Sphygmomanometer. We measured weight of individuals, made individual stand on the machine and kept aside all the things and accessories like mobile phone, heavy jackets and shoes. We used a spring scale to measure and weight of a body. In this project, a questionnaire was prepared and asked the subjects about their blood pressure and measured the weight.
{"title":"Relationship between Normal Blood Pressure and Body Weight","authors":"","doi":"10.33140/jcei.04.01.10","DOIUrl":"https://doi.org/10.33140/jcei.04.01.10","url":null,"abstract":"The objective of the present study was to compare any relationship between normal blood pressure and body weight. Normal blood pressure is very crucial for our life. Blood pressure is important because it provides oxygen and nutrients to our tissues and organs, this pressure cause the blood to flow throughout the body via arteries. Blood pressure is developed when our heart pumps the blood on contraction with heart beats. Body weight of human is measured in kilograms. Body weight fluctuation occurs due to the water amount in our body. There are many methods to access the body weight like dual-energy X-ray absorptiometry and the percentage of muscles, fats and bones in a human body. We used an instrument known as Sphygmomanometer. We measured weight of individuals, made individual stand on the machine and kept aside all the things and accessories like mobile phone, heavy jackets and shoes. We used a spring scale to measure and weight of a body. In this project, a questionnaire was prepared and asked the subjects about their blood pressure and measured the weight.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83308775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The target of the existing study was to relate chicken likeness with blood glucose level. Blood glucose level or blood sugar level or blood sugar level concentration is the level of the glucose existing in the blood of homo sapiens and mammals. Sum total of 100 students participate in the current research. We made a question sheet and got access to the blood sugar level of the participants. The participants were the students of Bahauddin Zakariya University, Multan, Pakistan. At the end we concluded that there is no relation between chicken likeness and blood sugar level.
{"title":"Association of Chicken Likeness with Blood Glucose Level","authors":"M. Qadir, S. Batool","doi":"10.33140/jcei.04.01.14","DOIUrl":"https://doi.org/10.33140/jcei.04.01.14","url":null,"abstract":"The target of the existing study was to relate chicken likeness with blood glucose level. Blood glucose level or blood sugar level or blood sugar level concentration is the level of the glucose existing in the blood of homo sapiens and mammals. Sum total of 100 students participate in the current research. We made a question sheet and got access to the blood sugar level of the participants. The participants were the students of Bahauddin Zakariya University, Multan, Pakistan. At the end we concluded that there is no relation between chicken likeness and blood sugar level.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83514124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Goal and the intension of the recent course were to show the connectivity between the blood pressure and ladyfinger likeness. Blood pressure or BP is the pressure exerted on the walls of the blood vessels when the blood circulates. Blood pressure is measured by the device called sphygmomanometer. The normal range of the blood pressure is 80mmHg to 120mmHg. The first is the diastolic blood pressure and the later is systolic blood pressure. Ladyfinger is the green vegetable which helps in controlling the blood pressure. During the sampling, we made a Performa about the connectivity of blood pressure and ladyfinger likeness. Gross of 188 colleagues were involved in this Performa study to which we questioned about their blood pressure. These colleagues are the undergraduate students of Bahauddin Zakariya University. It was concluded that the males who like ladyfinger have higher blood pressure and the females who dislike ladyfinger also have the high blood pressure.
{"title":"Interlink Between the Blood Pressure and Ladyfinger Likeness","authors":"","doi":"10.33140/jcei.04.01.06","DOIUrl":"https://doi.org/10.33140/jcei.04.01.06","url":null,"abstract":"Goal and the intension of the recent course were to show the connectivity between the blood pressure and ladyfinger likeness. Blood pressure or BP is the pressure exerted on the walls of the blood vessels when the blood circulates. Blood pressure is measured by the device called sphygmomanometer. The normal range of the blood pressure is 80mmHg to 120mmHg. The first is the diastolic blood pressure and the later is systolic blood pressure. Ladyfinger is the green vegetable which helps in controlling the blood pressure. During the sampling, we made a Performa about the connectivity of blood pressure and ladyfinger likeness. Gross of 188 colleagues were involved in this Performa study to which we questioned about their blood pressure. These colleagues are the undergraduate students of Bahauddin Zakariya University. It was concluded that the males who like ladyfinger have higher blood pressure and the females who dislike ladyfinger also have the high blood pressure.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83385848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective of present project “Bitter Gourd relish and Pulse Rate Relationship” was to investigate the normal pulse rate of subjects and relate with likeliness of bitter gourd. Subjects that took part in this project were 219 in number. Pulse rate is a means of physical examination of patient’s body and diagnosing the problem. Pulse rate is the beats (blood pumping to body) of heart in a minute. The status (regular, fast, low, strong) of pulse indicated the physical state of subject. Bitter gourd, a vegetable enrich in phytonutrient, anti-oxidants, dietary fiber and vitamin C, also disliked by subjects because of its bitterness. A protocol was followed to find a relationship for pulse rate measurement and questionnaire. Assistance of every subject helped in survey completion. Results were obtained by t-Test and relationship was observed that helped in doing conclusion. P-value was nonsignificant which meant no relation between bitter gourd and pulse rate measurement.
{"title":"Bitter Gourd relish and Pulse Rate Relationship","authors":"","doi":"10.33140/jcei.04.01.11","DOIUrl":"https://doi.org/10.33140/jcei.04.01.11","url":null,"abstract":"The objective of present project “Bitter Gourd relish and Pulse Rate Relationship” was to investigate the normal pulse rate of subjects and relate with likeliness of bitter gourd. Subjects that took part in this project were 219 in number. Pulse rate is a means of physical examination of patient’s body and diagnosing the problem. Pulse rate is the beats (blood pumping to body) of heart in a minute. The status (regular, fast, low, strong) of pulse indicated the physical state of subject. Bitter gourd, a vegetable enrich in phytonutrient, anti-oxidants, dietary fiber and vitamin C, also disliked by subjects because of its bitterness. A protocol was followed to find a relationship for pulse rate measurement and questionnaire. Assistance of every subject helped in survey completion. Results were obtained by t-Test and relationship was observed that helped in doing conclusion. P-value was nonsignificant which meant no relation between bitter gourd and pulse rate measurement.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77613650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective of present study was to see the effect of nicotine addiction on pulse rate. Nicotine can cause cardiovascular diseases and it also affect pulse rate by increasing its speed. So it was concluded that the docents who are addicted to tea have higher pulse rate and who are not addicted to tea they have normal or slow pulse rate.
{"title":"Audit to See the Effect of Nicotine Addiction on Pulse Rate","authors":"M. Qadir, Hina Batool","doi":"10.33140/jcei.04.01.04","DOIUrl":"https://doi.org/10.33140/jcei.04.01.04","url":null,"abstract":"Objective of present study was to see the effect of nicotine addiction on pulse rate. Nicotine can cause cardiovascular diseases and it also affect pulse rate by increasing its speed. So it was concluded that the docents who are addicted to tea have higher pulse rate and who are not addicted to tea they have normal or slow pulse rate.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83171835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article aims to analyze pathogenetic mechanisms of autoimmune diseases development including disorders of both cellular and humoral immunity. The standard drug therapy with corticosteroids and cytostatic leads to a number of side effects such as lipid metabolism disorders (Kushing-syndrome), arterial hypertension, diabetes, and osteoporosis each of which is to be additionally treated. Chimeric monoclonal antibodies (rituximab, natalizumab, etc.) can also cause complications. Therefore apheresis therapy with removal of autoantibodies, circulating immune complexes and other pathological metabolites is pathogenetically justified. However, the greatest effect is reached by means of extracorporeal immunopharmacotherapy when, besides antibodies removal by means of plasmapheresis one performs selection of lymphocytes and their temporary incubation with corticosteroids and cytostatics, which are then returned to the patient. Such targeted immunosuppression is much more effective then “pulse therapy” with minimum negative consequences for the body. At the same time a supporting drug therapy can be carried out with half smaller doses.
{"title":"Extracorporeal Immunopharmacotherapy of Autoimmune Diseases","authors":"","doi":"10.33140/jcei.04.01.08","DOIUrl":"https://doi.org/10.33140/jcei.04.01.08","url":null,"abstract":"The article aims to analyze pathogenetic mechanisms of autoimmune diseases development including disorders of both cellular and humoral immunity. The standard drug therapy with corticosteroids and cytostatic leads to a number of side effects such as lipid metabolism disorders (Kushing-syndrome), arterial hypertension, diabetes, and osteoporosis each of which is to be additionally treated. Chimeric monoclonal antibodies (rituximab, natalizumab, etc.) can also cause complications. Therefore apheresis therapy with removal of autoantibodies, circulating immune complexes and other pathological metabolites is pathogenetically justified. However, the greatest effect is reached by means of extracorporeal immunopharmacotherapy when, besides antibodies removal by means of plasmapheresis one performs selection of lymphocytes and their temporary incubation with corticosteroids and cytostatics, which are then returned to the patient. Such targeted immunosuppression is much more effective then “pulse therapy” with minimum negative consequences for the body. At the same time a supporting drug therapy can be carried out with half smaller doses.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74824226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wheezing in infancy and childhood is a common condition; however it is not a single disorder and can be due to causes other than asthma. Wheezing is a musical, expiratory sound due to narrowing and hyper responsiveness of the intra-thoracic and extra thoracic airways. Not all wheezing is asthma. Wheezing-associated respiratory illnesses in children are often described as asthma; however while most children with asthma show symptoms of wheezing. Wheezing, coughing and breathlessness are common in young children, and can all be symptoms of conditions other than asthma. Bronchiolitis refers to a first episode of wheezing, with respiratory distress triggered by a viral infection. Episodic wheezing refers to discrete episodes of wheezing without intermittent symptoms. Unremitting wheezing refers to distinct episodes of wheezing with intermittent symptoms, such as coughing or wheezing at night or in response to exercise, crying, laughter, mist, or cold air. Environmental conditions that increase the rate of bacterial and viral infections are risk factors for transient wheezing, but its relationship to asthma remains unclear. Children with frequent simple colds and other common childhood infections in infancy are less likely to develop persistent wheezing in later childhood. Many preschool children with viral induced wheezing will outgrow these symptoms, and do not have asthma. Generally, asthma is identified by the presence of cough, wheeze and breathing difficulty, together with features of atopy (or a family history of atopy or asthma) and impaired lung function evidenced by spirometry. It is important to explain to parents/ carers that wheezing in an infant or preschooler does not mean the child will have asthma or allergies by primary school age. In preschool-aged children with recurrent wheeze (e.g. four or more episodes per year), consider using the Asthma Predictive Index, to estimate whether children are likely to have asthma during primary school years. Asthma Prediction Index has some major criteria and minor criteria. Major criteria are diagnosis of asthma in one or both parent, Diagnosis of atopic dermatitis during the first 3 yr. of life, Sensitization against >1 allergen, Minor criteria- Milk, egg, or peanut sensitization. Associated with respiratory infections, Eosinophilia >4%. In the first 3 years of life if anyone who have 1 major criteria or 2 minor criteria is present in one episode, the possibility of asthma in 6-13 years is 59% but 2 episodes possibility is 77%. Investigation -Chest X-Ray, spirometry, CT scan of Chest and Fiberoptic Bronchoscope. It is usually not necessary if history of “classic” asthma or, patient response to salbutamol and or steroid; then only spirometry should be done. But need other investigation when Chronic cough (>1 month), recurrent pneumonia, persistent signs or symptoms are seen despite therapy. Bronchomalacia, esophageal dilatation, foreign body aspiration, vocal cord dysfunction, viral pneumonia alle
{"title":"Wheezing in Childhood- not Always Asthma -Review","authors":"Atiar Rahman, Nafisa Rahman","doi":"10.33140/jcei.04.01.05","DOIUrl":"https://doi.org/10.33140/jcei.04.01.05","url":null,"abstract":"Wheezing in infancy and childhood is a common condition; however it is not a single disorder and can be due to causes other than asthma. Wheezing is a musical, expiratory sound due to narrowing and hyper responsiveness of the intra-thoracic and extra thoracic airways. Not all wheezing is asthma. Wheezing-associated respiratory illnesses in children are often described as asthma; however while most children with asthma show symptoms of wheezing. Wheezing, coughing and breathlessness are common in young children, and can all be symptoms of conditions other than asthma. Bronchiolitis refers to a first episode of wheezing, with respiratory distress triggered by a viral infection. Episodic wheezing refers to discrete episodes of wheezing without intermittent symptoms. Unremitting wheezing refers to distinct episodes of wheezing with intermittent symptoms, such as coughing or wheezing at night or in response to exercise, crying, laughter, mist, or cold air. Environmental conditions that increase the rate of bacterial and viral infections are risk factors for transient wheezing, but its relationship to asthma remains unclear. Children with frequent simple colds and other common childhood infections in infancy are less likely to develop persistent wheezing in later childhood. Many preschool children with viral induced wheezing will outgrow these symptoms, and do not have asthma. Generally, asthma is identified by the presence of cough, wheeze and breathing difficulty, together with features of atopy (or a family history of atopy or asthma) and impaired lung function evidenced by spirometry. It is important to explain to parents/ carers that wheezing in an infant or preschooler does not mean the child will have asthma or allergies by primary school age. In preschool-aged children with recurrent wheeze (e.g. four or more episodes per year), consider using the Asthma Predictive Index, to estimate whether children are likely to have asthma during primary school years. Asthma Prediction Index has some major criteria and minor criteria. Major criteria are diagnosis of asthma in one or both parent, Diagnosis of atopic dermatitis during the first 3 yr. of life, Sensitization against >1 allergen, Minor criteria- Milk, egg, or peanut sensitization. Associated with respiratory infections, Eosinophilia >4%. In the first 3 years of life if anyone who have 1 major criteria or 2 minor criteria is present in one episode, the possibility of asthma in 6-13 years is 59% but 2 episodes possibility is 77%. Investigation -Chest X-Ray, spirometry, CT scan of Chest and Fiberoptic Bronchoscope. It is usually not necessary if history of “classic” asthma or, patient response to salbutamol and or steroid; then only spirometry should be done. But need other investigation when Chronic cough (>1 month), recurrent pneumonia, persistent signs or symptoms are seen despite therapy. Bronchomalacia, esophageal dilatation, foreign body aspiration, vocal cord dysfunction, viral pneumonia alle","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78078392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood sugar level is actually the estimation of the total glucose sugar content in the one’s blood. Insulin and Glucagon are the two key hormones responsible for maintaining homeostasis which sustain blood glucose level. Hypoglycemia and Hyperglycemia are the two conditions associated with blood sugar level. In case of hypoglycemia, blood glucose level falls below the normal level of glucose in the blood while hyperglycemia is the condition of elevated blood glucose level than the normal range. Different tests are available to test the blood glucose level of an individual. The central objective of this project was to assess the inter-connection between one’s being suriphobic and their blood sugar level at fasting. Phobia is a word associated with the condition of extreme fear from a series of specified events. Suriphobia or mice fear is the term used for those individuals who extremely fear from mice, rats, rodents etc. This study was a questionnaire based project to assess the fact that if there is any inter-connection between people’s being suriphobic and their blood glucose level at fasting. For this purpose blood sugar level of the sample population was calculated using Glucometer. Statistical Analysis point towards the significant results if this study as the calculated p-value was exact of the standard p¬-value which is p ≤ 0.05. Therefore, the fact that there is a significant relation between individual’s being Suriphobe and their Blood Glucose Level at fasting is proved.
{"title":"Assessment of Inter-Connection between Suriphobia and Individual’s Blood Glucose Level: A Questionnaire Centred Project","authors":"Ghalia Batool Alvi, M. Qadir, Baber Ali","doi":"10.33140/jcei.04.01.09","DOIUrl":"https://doi.org/10.33140/jcei.04.01.09","url":null,"abstract":"Blood sugar level is actually the estimation of the total glucose sugar content in the one’s blood. Insulin and Glucagon are the two key hormones responsible for maintaining homeostasis which sustain blood glucose level. Hypoglycemia and Hyperglycemia are the two conditions associated with blood sugar level. In case of hypoglycemia, blood glucose level falls below the normal level of glucose in the blood while hyperglycemia is the condition of elevated blood glucose level than the normal range. Different tests are available to test the blood glucose level of an individual. The central objective of this project was to assess the inter-connection between one’s being suriphobic and their blood sugar level at fasting. Phobia is a word associated with the condition of extreme fear from a series of specified events. Suriphobia or mice fear is the term used for those individuals who extremely fear from mice, rats, rodents etc. This study was a questionnaire based project to assess the fact that if there is any inter-connection between people’s being suriphobic and their blood glucose level at fasting. For this purpose blood sugar level of the sample population was calculated using Glucometer. Statistical Analysis point towards the significant results if this study as the calculated p-value was exact of the standard p¬-value which is p ≤ 0.05. Therefore, the fact that there is a significant relation between individual’s being Suriphobe and their Blood Glucose Level at fasting is proved.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83881634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Tchouangueu, L. B. Mabeku, A. Lissom, Loveline N. Ngu, S. B. Tchuandom, J. Tchadji, L. Djukouo, C. S. S. Ngane, Alfred A Ngoh, Herve F. Ouambo, Georgia Ambada, Anna Gutiérrez, C. Esimone, Chae Gyu Park, A. B. Waffo, G. Nchinda
The use of antiretroviral (ARV) has been one of the most effective means of preventing vertical transmission of the human immunodeficiency virus (HIV) to exposed children born of HIV infected mothers. Nevertheless, responses to childhood vaccination against Hepatitis B virus (HBV) infections remain suboptimal in HIV exposed uninfected children irrespective of maternal ARV prophylaxis. In a cross-sectional study we have assessed the impact of in-utero exposure to ARV on paediatric HBV vaccination. Anti-HBV surface antigen specific antibodies (anti-HBs abs) were measured in plasma specimens from 44 healthy children unexposed to both HIV and ARV (HU), 25 HIV-exposed uninfected children naïve to intrauterine exposure to ARV (HEU.AR - ), 29 ARV and HIV-exposed uninfected children during pregnancy (HEU.ARV +), 50 children vertically infected with HIV but naïve to intrauterine exposure to ARV (HEI.ARV - ) and 22 children vertically infected with HIV with in utero exposure to ARV (HEI.ARV +). The protective seroconversion rate after childhood HBV vaccination (anti-HBs ≥10 mUI/ml) among HEU.ARV + children (58%) was significantly lower relative to both HEU.ARVc - (100%, P=0.0010) and the healthy unexposed children (92 %, P=0.0069). Similarly, HEI.ARV + children also had significantly lower anti-HBs IgM antibody responses when compared to both HU (p=0.0003) and HEI.ARV - (0.0001) children respectively. Thus in-utero exposure to ARV probably contributes in reducing HBV vaccine antibody response rate in both HIV exposed uninfected and vertically infected children after childhood vaccination. Nevertheless, the overall impact of ARV was to improve anti-HBs IgG responses in HIV infected children suggesting a possible role in immune reconstitution leading to improved IgG antibody responses.
{"title":"Antibody Responses Specific to Hepatitis B Virus Vaccine in Children Exposed InUtero to Antiretroviral Therapy","authors":"T. Tchouangueu, L. B. Mabeku, A. Lissom, Loveline N. Ngu, S. B. Tchuandom, J. Tchadji, L. Djukouo, C. S. S. Ngane, Alfred A Ngoh, Herve F. Ouambo, Georgia Ambada, Anna Gutiérrez, C. Esimone, Chae Gyu Park, A. B. Waffo, G. Nchinda","doi":"10.33140/jcei.04.04.01","DOIUrl":"https://doi.org/10.33140/jcei.04.04.01","url":null,"abstract":"The use of antiretroviral (ARV) has been one of the most effective means of preventing vertical transmission of the human immunodeficiency virus (HIV) to exposed children born of HIV infected mothers. Nevertheless, responses to childhood vaccination against Hepatitis B virus (HBV) infections remain suboptimal in HIV exposed uninfected children irrespective of maternal ARV prophylaxis. In a cross-sectional study we have assessed the impact of in-utero exposure to ARV on paediatric HBV vaccination. Anti-HBV surface antigen specific antibodies (anti-HBs abs) were measured in plasma specimens from 44 healthy children unexposed to both HIV and ARV (HU), 25 HIV-exposed uninfected children naïve to intrauterine exposure to ARV (HEU.AR - ), 29 ARV and HIV-exposed uninfected children during pregnancy (HEU.ARV +), 50 children vertically infected with HIV but naïve to intrauterine exposure to ARV (HEI.ARV - ) and 22 children vertically infected with HIV with in utero exposure to ARV (HEI.ARV +). The protective seroconversion rate after childhood HBV vaccination (anti-HBs ≥10 mUI/ml) among HEU.ARV + children (58%) was significantly lower relative to both HEU.ARVc - (100%, P=0.0010) and the healthy unexposed children (92 %, P=0.0069). Similarly, HEI.ARV + children also had significantly lower anti-HBs IgM antibody responses when compared to both HU (p=0.0003) and HEI.ARV - (0.0001) children respectively. Thus in-utero exposure to ARV probably contributes in reducing HBV vaccine antibody response rate in both HIV exposed uninfected and vertically infected children after childhood vaccination. Nevertheless, the overall impact of ARV was to improve anti-HBs IgG responses in HIV infected children suggesting a possible role in immune reconstitution leading to improved IgG antibody responses.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82238565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}