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Effect of a pharmacy-driven rapid bacteremia response program on outcomes in adult patients with extended-spectrum beta-lactamase bacteremia: A retrospective, quasi-experimental study
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-12-14 DOI: 10.1002/jac5.2063
Elena A. Swingler Pharm.D., MBA, Madison Clark Pharm.D., Sarah E. Moore Pharm.D., Matthew Song Pharm.D., Jamison Montes de Oca Pharm.D., Stephen Furmanek MPH, M.S., Thomas Chandler MPH, Ashley M. Wilde Pharm.D.

Introduction

Rapid diagnostic technology can improve patient outcomes, particularly when combined with Antimicrobial Stewardship Program (ASP) intervention. Bacteremic patients due to drug-resistant organisms are most likely to benefit from rapid diagnostic technologies as they are more likely to be prescribed inadequate empiric therapy. The purpose of this study was to analyze the impact of a pharmacy-driven Rapid Bacteremia Response Program (RBRP) on the process and clinical outcomes of patients with bacteremia due to an extended-spectrum beta-lactamase (ESBL)-producing organism.

Methods

A retrospective, quasi-experimental study was conducted at a large healthcare system. The RBRP was implemented in 2017 to expedite antimicrobial therapy for bacteremia based on Gram stain and Verigene® system (Luminex Corp, Austin, TX, USA) results. Adults hospitalized with ESBL bacteremia were evaluated pre-intervention and post-intervention (utilizing the RBRP). The primary outcome was time to active therapy. Secondary outcomes included in-hospital and 30-day mortality, length of hospital and intensive care unit (ICU) stay, and factors associated with mortality.

Results

A total of 200 patients were included: 100 patients in the pre-intervention and 100 patients in the post-intervention group. The post-intervention group resulted in 6.4 h faster time to active therapy from blood culture collection (median 22.8 h pre-intervention vs. 16.4 h post-intervention, p = 0.001). No statistical difference was identified for the length of hospital or ICU stay and in-hospital or 30-day mortality between groups. Multivariable analysis identified age, male sex, quick Pitt bacteremia score, and hospital-acquired infection to be significantly associated with 30-day mortality.

Conclusion

The pharmacy-driven RBRP resulted in decreased time to active therapy for patients with ESBL bacteremia.

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引用次数: 0
Medication therapy management: The evolution of clinical pharmacy services in U.S. Community-Based Pharmacy Practice—An opinion of the community-based practice and research network of the American College of Clinical Pharmacy 药物治疗管理:美国社区药学实践中临床药学服务的演变——对美国临床药学学院社区实践与研究网络的看法
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-12-11 DOI: 10.1002/jac5.2047
Emily Eddy Pharm.D., MSLD, Jordan Marie Ballou Pharm.D., Jessica B. Finke Pharm.D., Wesley Nuffer Pharm.D., Carmela Avena – Woods Pharm.D., Veronica T. Bandy Pharm.D., M.S., William Doucette Ph.D., Kendall Guthrie Pharm.D., Randy McDonough Pharm.D., Margie E. Snyder Pharm.D., MPH, FCCP, Jason Varin Pharm.D.

Pharmacists in all settings are continually expanding their roles and responsibilities and advocating for the profession. Pharmacists, as medication experts, are trained to identify and resolve medication therapy problems. The act of providing clinical pharmacist expertise is not tied to a specific practice setting, but rather is the mindset in which a pharmacist approaches patient-centered practice. In community-based pharmacy settings, pharmacists have been providing clinical services for years through Medication Therapy Management (MTM) and other enhanced services which prioritize quality care. This manuscript will outline the history of the pharmacist's role in managing patients utilizing MTM, present evidence of positive patient care outcomes from pharmacist-led services in the community-based setting, and provide recommendations for United States payers to acknowledge and increase payment for pharmacist-led services. This paper represents the opinion of the Community-Based Practice and Research Network of the American College of Clinical Pharmacy (ACCP) in the United States. It does not necessarily represent an official ACCP commentary, guideline, or statement of policy or position.

所有环境中的药剂师都在不断扩大他们的角色和责任,并倡导职业。药剂师作为药物专家,接受过识别和解决药物治疗问题的培训。提供临床药师专业知识的行为与特定的实践环境无关,而是药剂师以患者为中心的实践方法的心态。在以社区为基础的药房环境中,药剂师多年来一直通过药物治疗管理(MTM)和其他优先考虑高质量护理的强化服务提供临床服务。本文将概述药剂师在利用MTM管理患者中的作用的历史,提供证据表明,在社区环境中,药剂师主导的服务对患者的护理结果是积极的,并为美国付款人提供建议,以承认和增加药剂师主导的服务的支付。本文代表了美国临床药学学院(ACCP)社区实践与研究网络的观点。它不一定代表一个官方的ACCP评论,指导方针,或政策或立场的声明。
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引用次数: 0
Tools for clinical pharmacists to identify medications that can cause drug-induced cognitive impairment: A systematic review 临床药剂师识别可引起药物性认知障碍的药物的工具:系统回顾
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-12-10 DOI: 10.1002/jac5.2049
Jacob Stanton B.S., Michael R. Gionfriddo Pharm.D., Ph.D., Gail B. Rattinger Pharm.D., Ph.D., Yuan Fang Ph.D., Mia E. Lussier Pharm.D., M.S.

Cognitive impairment affects around 19% of community-dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive-impairing medications through cognitive-focused medication reviews or as part of comprehensive medication management. Multiple tools exist to help pharmacists and other practitioners identify these medications, yet a comprehensive description of these tools has not been undertaken. We searched EBSCO MEDLINE, PubMed, EMBASE, CINAHL, and PsycInfo from inception to August 4, 2023, using search terms relative to medications and cognition. Studies were included if they detailed a tool to assess the cognitive burden of a medication regimen. Abstracts and full texts were screened independently and in duplicate. Any disagreements at the level of full-text screening were resolved by consensus. Eligible studies underwent data extraction by two authors independently and in duplicate using a data extraction form. Our search identified 13 126 articles of which only four tools were initially included. Additionally, we identified seven articles from the reference lists of excluded review articles for a final inclusion count of 11 tools. Articles were published between 2001 and 2017. Nine of 11 tools (82%) were focused solely on anticholinergic medications, while only one tool indicated a clinically relevant cutoff value and alternative medication recommendations. While there are many tools to assess the cognitive burden from medications, many are limited by the development date, focus on anticholinergic medications, or lack clinically useful information. Further research is needed to develop more comprehensive, up-to-date, and readily implementable tools that clinical pharmacists can utilize to assess medication-induced cognitive risks. Such as tool could be applied by pharmacists in many settings to optimize medication use and improve patient outcomes.

在美国,大约19%的社区老年人受到认知障碍的影响。药剂师可以通过以认知为重点的药物审查或作为综合药物管理的一部分,在识别和减少认知损害药物方面发挥重要作用。有多种工具可以帮助药剂师和其他从业人员识别这些药物,但尚未对这些工具进行全面描述。我们检索了EBSCO MEDLINE, PubMed, EMBASE, CINAHL和PsycInfo从成立到2023年8月4日,使用与药物和认知相关的搜索词。如果研究详细说明了一种评估药物治疗方案认知负担的工具,则将其纳入研究。摘要和全文独立筛选,一式两份。全文筛选层面的任何分歧均以协商一致方式解决。符合条件的研究由两位作者独立提取数据,并使用数据提取表一式两份。我们的搜索确定了13 126篇文章,其中只有4种工具最初被纳入。此外,我们从排除的综述文章的参考文献列表中确定了7篇文章,最终纳入了11个工具。文章发表于2001年至2017年之间。11个工具中有9个(82%)只关注抗胆碱能药物,而只有一个工具显示了临床相关的临界值和替代药物建议。虽然有许多工具可以评估药物带来的认知负担,但许多工具受到开发日期的限制,主要集中在抗胆碱能药物上,或者缺乏临床有用的信息。需要进一步的研究来开发更全面、最新和易于实施的工具,临床药剂师可以利用这些工具来评估药物引起的认知风险。这种工具可以由药剂师在许多环境中应用,以优化药物使用和改善患者的结果。
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引用次数: 0
Clinical impact of a tiered, pharmacist-driven remote patient monitoring protocol utilizing self-measured blood pressure readings
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-12-10 DOI: 10.1002/jac5.2059
Zachary Hovis Pharm.D., Ryan Hanson M.S., Erin DeJarlais DPT, MBA

Introduction

Pairing self-measured blood pressure (SMBP) with protocolized, non-physician follow-up consistently improves hypertension (HTN) management. However, these interventions are often resource-intensive and rely on a degree of technological proficiency that may exclude a vulnerable subset of the population.

Objectives

The primary objective of this study was to determine the rate of attainment of blood pressure (BP) control (defined as <140/<90 mmHg) based on the most recent clinic-measured BP readings 12 months or more after enrollment in the Digital Care Monitoring program. The secondary objective was to determine if there was a difference between the most recent clinic-measured systolic and diastolic BP readings before enrollment compared with 12 months or more after the enrollment eligibility period.

Methods

This study examined the impact of a tiered, non-physician SMBP program, engaging patients through a familiar communication medium to relay home BP readings. A pre-post quality improvement study was conducted in the outpatient arm of an integrated delivery network. Patients meeting selection criteria were invited to voluntarily enroll bi-monthly from October 2021 to July 2023. Patients consenting to enrollment received reminders twice weekly to respond with home BP readings, and an outreach protocol was established utilizing a medical assistant and clinical pharmacist.

Results

The rate of attainment of BP control 12 months or more after the enrollment eligibility period was found to be 79.2% (p < 0.01). BP dropped significantly over the 12-month treatment course with a mean systolic BP difference of 19.97 mmHg (p < 0.001) and a mean diastolic BP difference of 12.34 mmHg (p < 0.001).

Conclusion

The results indicate that a tiered, pharmacist-driven remote patient monitoring protocol utilizing SMBP readings is an effective management strategy to reduce BP in patients with uncontrolled HTN.

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引用次数: 0
Impact of an intern-supported antiviral stewardship program for cytomegalovirus prophylaxis and management in high-risk abdominal solid organ transplant recipients
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-12-09 DOI: 10.1002/jac5.2061
Lindsey Mahn B.S., Mary Moss Chandran Pharm.D., FCCP, Christina Teeter Doligalski Pharm.D., FCCP, Laura Mincemoyer Chargualaf Pharm.D.

Introduction

Cytomegalovirus (CMV) infection is associated with increased graft loss and mortality after solid organ transplantation (SOT). CMV infection risk is highest among seronegative recipients of seropositive donors (D+/R-). Careful monitoring is imperative to ensure appropriate care.

Objectives

This study investigates the impact of intern-supported pharmacist-driven monitoring on CMV outcomes in D+/R- abdominal SOT recipients.

Methods

A single-center retrospective cohort study was conducted in CMV D+/R- abdominal SOT recipients transplanted between August 1, 2021, and July 31, 2023 to compare recipients undergoing pharmacy intern review versus standard monitoring. A pharmacy student intern reviewed a list of recipients maintained in the electronic health record weekly to ensure proper CMV prophylaxis and management. Following institutional protocols, the intern identified and recommended interventions to the pharmacists for implementation. Primary outcomes included the incidence of CMV infection within 9 months posttransplant and time to CMV eradication after infection. Secondary outcomes included the incidence of antiviral resistance, viral breakthrough, allograft loss, and recipient death.

Results

69 D+/R- SOT recipients were included (36 control, 33 intervention). Baseline demographics were similar. There was a nonsignificant decrease in CMV infection within 9 months posttransplant in the intervention group. However, the mean time to CMV eradication after infection was significantly shorter in the intervention group (63 days vs. 24 days, p = 0.004). No differences in secondary outcomes were observed.

Conclusions

CMV infection rates remained elevated in D+/R- SOT recipients after transplant despite frequent reviews of prophylaxis and laboratory monitoring, which is likely a result of seronegative status and global immunosuppression. However, eradication of CMV infection can be significantly impacted by close monitoring, such as that provided by a pharmacy student intern, to reduce the time of active infection. This dramatic reduction in time to eradication has the potential to reduce the risk for negative allograft and recipient outcomes associated with CMV infection.

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引用次数: 0
Addressing code response challenges: Development of a pharmacist-focused training program at an Academic Medical Center
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-12-05 DOI: 10.1002/jac5.2062
Lindsay Jacobs Pharm.D., MPH, Jennifer Tawwater Pharm.D., Lisa Skariah Pharm.D., Bhavyata Parag Pharm.D., Klayton Ryman Pharm.D., Chephra McKee Pharm.D., Kathryn Cox Pharm.D., Whitney Chaney Pharm.D., Josephine Tenii Pharm.D., Meagan Johns Pharm.D., MBA

Introduction

Pharmacists are essential to the multidisciplinary team during code response. Commercially available basic and advanced-life support training programs are not tailored for the depth of medication-specific content essential for pharmacists to competently respond to codes. Opportunities exist to provide additional training to improve pharmacists' code response.

Objective

To develop pharmacist-specific didactic education and hands-on assessments for adult code response.

Methods

At our institution, acute care clinical staff pharmacists attend all adult codes. A mandatory pharmacist training program was designed to meet minimum institutional expectations for code response and address knowledge gaps. The program included three components: (1) online training module, (2) knowledge-based assessment, and (3) hands-on assessment. Pharmacists were surveyed pre- and post-completion of the training program. The surveys consisted of 15 Likert scale questions and open-ended questions. Chi-square tests were used to compare a “positive” response to pre- and post-survey questions. A “positive” response was defined as “Strongly Agree” or “Agree” on the Likert questions.

Results

Seventy-three pharmacists completed the training program with 71 passing the hands-on skills training on the first attempt. The pre- and post-intervention survey was completed by 43/74 (58.1%) and 33/82 (40.2%) of pharmacists, respectively. A statistically significant increase in the number of “positive” survey responses was noted in 7 of the 15 Likert scale questions post-intervention, with nominal improvements in the remaining 8. There were notable improvements in pharmacist perceived familiarity and comfort with medication locations (9% vs. 64%) and preparation (44% vs. 76%), and greater confidence in using available resources.

Conclusion

The pharmacist-specific code response training resulted in notable improvements in disclosed familiarity and comfort with code responsibilities. This training was transitioned into an annual competency module that may be used as a framework for other institutions implementing a similar process to maintain a standard level of competence in code response for pharmacists.

{"title":"Addressing code response challenges: Development of a pharmacist-focused training program at an Academic Medical Center","authors":"Lindsay Jacobs Pharm.D., MPH,&nbsp;Jennifer Tawwater Pharm.D.,&nbsp;Lisa Skariah Pharm.D.,&nbsp;Bhavyata Parag Pharm.D.,&nbsp;Klayton Ryman Pharm.D.,&nbsp;Chephra McKee Pharm.D.,&nbsp;Kathryn Cox Pharm.D.,&nbsp;Whitney Chaney Pharm.D.,&nbsp;Josephine Tenii Pharm.D.,&nbsp;Meagan Johns Pharm.D., MBA","doi":"10.1002/jac5.2062","DOIUrl":"https://doi.org/10.1002/jac5.2062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Pharmacists are essential to the multidisciplinary team during code response. Commercially available basic and advanced-life support training programs are not tailored for the depth of medication-specific content essential for pharmacists to competently respond to codes. Opportunities exist to provide additional training to improve pharmacists' code response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To develop pharmacist-specific didactic education and hands-on assessments for adult code response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>At our institution, acute care clinical staff pharmacists attend all adult codes. A mandatory pharmacist training program was designed to meet minimum institutional expectations for code response and address knowledge gaps. The program included three components: (1) online training module, (2) knowledge-based assessment, and (3) hands-on assessment. Pharmacists were surveyed pre- and post-completion of the training program. The surveys consisted of 15 Likert scale questions and open-ended questions. Chi-square tests were used to compare a “positive” response to pre- and post-survey questions. A “positive” response was defined as “Strongly Agree” or “Agree” on the Likert questions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventy-three pharmacists completed the training program with 71 passing the hands-on skills training on the first attempt. The pre- and post-intervention survey was completed by 43/74 (58.1%) and 33/82 (40.2%) of pharmacists, respectively. A statistically significant increase in the number of “positive” survey responses was noted in 7 of the 15 Likert scale questions post-intervention, with nominal improvements in the remaining 8. There were notable improvements in pharmacist perceived familiarity and comfort with medication locations (9% vs. 64%) and preparation (44% vs. 76%), and greater confidence in using available resources.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The pharmacist-specific code response training resulted in notable improvements in disclosed familiarity and comfort with code responsibilities. This training was transitioned into an annual competency module that may be used as a framework for other institutions implementing a similar process to maintain a standard level of competence in code response for pharmacists.</p>\u0000 </section>\u0000 </div>","PeriodicalId":73966,"journal":{"name":"Journal of the American College of Clinical Pharmacy : JACCP","volume":"8 1","pages":"34-46"},"PeriodicalIF":1.3,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jac5.2062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacist-managed diabetes care and change in A1C: A retrospective matched cohort study
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-12-05 DOI: 10.1002/jac5.2058
Nicholas C. Meyer Pharm.D., Fatme Younes Pharm.D., Carlina J. Grindeland Pharm.D., Monte L. Roemmich Pharm.D., Douglas W. Gugel-Bryant Pharm.D.

Introduction

Studies have demonstrated the positive impact of pharmacist-managed diabetes care (PMDC) on hemoglobin A1C (A1C) reduction from baseline, but data comparing the pharmacist's impact on usual medical care (UMC) are less robust.

Objectives

This study compared the A1C reduction in patients with diabetes enrolled in PMDC plus UMC (PMDC + UMC) with similar patients receiving UMC independent of clinical pharmacy services.

Methods

This was a retrospective, matched cohort study conducted at a large, not-for-profit healthcare system in North Dakota. Patients with diabetes who received care from an ambulatory care pharmacist in addition to UMC between July 2018 and June 2020 were included in the PMDC+UMC cohort. The comparator cohort included propensity-matched patients solely receiving UMC during the same period. The primary endpoint was the mean change in A1C at 12 months in both cohorts. The secondary endpoint was the percentage of patients in each cohort achieving an A1C <7% at 12 months. Normally distributed continuous variables were analyzed using the Wilcoxon rank sum test. Categorical data were analyzed using Chi-square tests.

Results

In total, 158 patients managed by a pharmacist met the inclusion criteria for the study. A matched cohort of 158 practitioner-managed patients was used for comparison. Pharmacist-managed patients achieved a greater mean reduction in A1C (−1.70%) at 12 months compared with those managed by practitioners only (−1.31%), a between-means difference of −0.39% (p = 0.0073). More patients managed by pharmacists (24.6%) reached an A1C of <7% compared with patients receiving UMC only (22.8%); however, the difference was not statistically significant.

Conclusion

Incorporation of PMDC for patients with diabetes is associated with a greater improvement in A1C at 12 months compared with UMC alone. Although not statistically significant, more patients referred to PMDC reached an A1C of <7%. Implementation of similar PMDC programs may help more patients reach their glycemic goals.

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引用次数: 0
Diversity, equity, inclusion, and accessibility: Alignment with the mission and core values of the American College of Clinical Pharmacy 多样性、公平性、包容性和可及性:与美国临床药学学院的使命和核心价值观保持一致
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-12-04 DOI: 10.1002/jac5.2052
Jimmi Hatton Kolpek Pharm.D., FCCP, Curtis E. Haas Pharm.D., FCCP, Jill M. Kolesar Pharm.D., M.S., FCCP, James E. Tisdale Pharm.D., FCCP

Responding to the changing landscape of health care is a critical responsibility of the American College of Clinical Pharmacy (ACCP). Aligned with its mission of extending the frontiers of clinical pharmacy, ACCP is committed to embracing diversity and inclusion as a core value. Creating a comprehensive organizational strategy reflecting the College's authentic endeavors to embrace the tasks required is an ongoing effort. ACCP is embracing an inclusive vision whereby all members can feel welcomed, valued, respected, and heard. Belief that the journey will bring diverse voices, leadership, and understanding for all clinical pharmacists sustains the College's motivation toward this goal. In this commentary, we, as past presidents of ACCP, are learning the challenges related to this endeavor and systematically addressing each issue. Each ACCP member is an essential partner as the College strives toward being an inclusive organizational home for all clinical pharmacists. This commentary summarizes the rationale for this work and the alignment of ACCP's efforts with its core values. We must remain firm in our belief that inclusive clinical pharmacy leaders can recognize diversity and equity gaps, mobilize as advocates to amplify underrepresented voices, and transform hope into action for future generations.

应对不断变化的卫生保健景观是美国临床药学学院(ACCP)的关键责任。与扩展临床药学前沿的使命一致,ACCP致力于将多样性和包容性作为核心价值。创建一个全面的组织战略,反映学院真正的努力,接受所需的任务是一个持续的努力。ACCP正在拥抱一个包容性的愿景,即所有成员都能感到受到欢迎、重视、尊重和倾听。相信旅程将带来不同的声音,领导和理解所有临床药师维持学院的动机朝着这一目标。在这篇评论中,作为ACCP的前任主席,我们正在了解与这一努力相关的挑战,并系统地解决每个问题。每个ACCP成员都是一个重要的合作伙伴,因为学院努力成为一个包容所有临床药师的组织之家。这篇评论总结了这项工作的基本原理,以及ACCP的努力与其核心价值的一致性。我们必须坚定我们的信念,即包容性临床药学领导者能够认识到多样性和公平差距,作为倡导者动员起来,扩大代表性不足的声音,并将希望转化为子孙后代的行动。
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引用次数: 0
Structural factors and their influence on the use of novel antidiabetic agents: Making the case for increased awareness and access to clinical pharmacy services
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-11-28 DOI: 10.1002/jac5.2050
Olga Monika Trejos Kweyete Pharm.D., Desrae Woods A.A., Joahn Okoumba B.S., Serena Jingchuan Guo M.D., Ph.D., John M. Allen Pharm.D., FCCP

Type 2 diabetes (T2D) affects over 38 million Americans, leading to significant health complications and substantial healthcare costs. Novel antidiabetic medications, such as SGLT2 inhibitors and GLP-1 receptor agonists, have shown promise in improving glycemic control and reducing cardiovascular risks. However, their underuse, particularly among minority populations, remains a concern. This review examines the impact of structural factors, including socioeconomic determinants and historical practices like redlining, on the utilization of new antidiabetic agents. Disparities in T2D outcomes are driven by inadequate access to care and neighborhood characteristics. Addressing these issues requires comprehensive strategies, including the integration of pharmacist support to enhance medication adherence and overall T2D management. Understanding the influence of structural racism on healthcare disparities is crucial for improving access and outcomes for all patients.

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引用次数: 0
Retrospective cohort study of ambulatory care pharmacist interventions’ impact on incidence of therapeutic response in anxiety and depression 门诊护理药师干预对焦虑、抑郁患者治疗反应影响的回顾性队列研究
IF 1.3 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-11-26 DOI: 10.1002/jac5.2046
Ashlyn M. Kiebach Pharm.D., Tara E. McAlpine Pharm.D., Mitchell H. Cavanaugh Pharm.D., Jessica A. Benzer Pharm.D.

Introduction

Ambulatory care pharmacists continue to expand their involvement in the management of various disease states across the United States, including anxiety and depression. There is limited literature assessing the clinical impact of these practice advances implemented by pharmacists who do not carry psychiatric training (i.e., psychiatric board certification or mental health training) within primary care.

Methods

This was a retrospective, multicenter, cohort study of adult patients who had at least one documented visit between February 2020 and August 2023 with an ambulatory care pharmacist who did not carry additional psychiatric training to comanage their diagnosis of depression and/or anxiety. The primary outcome was the achievement of a therapeutic response (a reduction of 50% or greater in Patient Health Questionnaire 9-item depression scale [PHQ-9] and/or the Generalized Anxiety Disorder 7-item scale [GAD-7] scores). Secondary outcomes included the change in PHQ-9 and/or GAD-7 scores, incidence of remission, predictors of therapeutic response, pharmacist intervention subtypes, and percentage use of pharmacogenomics.

Results

Therapeutic response for PHQ-9 was achieved for 60 (48.4%) of 124 patients included after utilization of an ambulatory care pharmacist without additional psychiatric training embedded in primary care. While two-thirds of patients had comorbid anxiety, 43 (57.4%) could not be evaluated for clinical improvement as they did not have available GAD-7 scores for analysis. Available PHQ-9 and GAD-7 scores had median score reductions of 5 (−11,0) and 4.5 (−7.75, 3.5), respectively, at approximately 6 months (p < 0.001 and p = 0.023). Patients had a median number of 4 (2, 5) visits with a pharmacist and a median number of 2 (1, 3) interventions.

Conclusions

Ambulatory care pharmacists, regardless of additional psychiatric training, can help patients achieve a therapeutic response for depression and anxiety as well as significantly improve PHQ-9 and GAD-7 scores. Additional education on the importance of GAD-7 monitoring is warranted given its lack of routine collection and evaluation among patients presenting with comorbid depression and anxiety.

门诊护理药剂师继续扩大他们在美国各种疾病状态管理的参与,包括焦虑和抑郁。在初级保健中,没有接受过精神病学培训(即精神病学委员会认证或心理健康培训)的药剂师实施这些实践进步的临床影响评估文献有限。方法:本研究是一项回顾性、多中心、队列研究,纳入了在2020年2月至2023年8月期间至少有一次门诊护理药剂师就诊记录的成年患者,该药剂师未接受额外的精神病学培训,以管理其抑郁和/或焦虑的诊断。主要结果是达到治疗反应(患者健康问卷9项抑郁量表[PHQ-9]和/或广泛性焦虑障碍7项量表[GAD-7]得分降低50%或以上)。次要结局包括PHQ-9和/或GAD-7评分的变化、缓解的发生率、治疗反应的预测因子、药剂师干预亚型和药物基因组学的使用百分比。结果124例患者中有60例(48.4%)在初级保健中没有接受额外的精神病学培训的门诊护理药剂师的帮助下获得了PHQ-9的治疗效果。虽然三分之二的患者患有共病性焦虑,但43例(57.4%)无法评估临床改善,因为他们没有可用的GAD-7评分进行分析。PHQ-9和GAD-7评分在大约6个月时的中位分数分别下降了5分(- 11,0)和4.5分(- 7.75,3.5)(p <; 0.001和p = 0.023)。患者与药剂师的就诊次数中位数为4(2,5)次,干预次数中位数为2(1,3)次。结论门诊药师在不接受额外精神病学培训的情况下,可以帮助患者达到治疗抑郁和焦虑的效果,并显著提高PHQ-9和GAD-7评分。鉴于在患有抑郁症和焦虑症的患者中缺乏常规收集和评估,有必要对GAD-7监测的重要性进行额外的教育。
{"title":"Retrospective cohort study of ambulatory care pharmacist interventions’ impact on incidence of therapeutic response in anxiety and depression","authors":"Ashlyn M. Kiebach Pharm.D.,&nbsp;Tara E. McAlpine Pharm.D.,&nbsp;Mitchell H. Cavanaugh Pharm.D.,&nbsp;Jessica A. Benzer Pharm.D.","doi":"10.1002/jac5.2046","DOIUrl":"https://doi.org/10.1002/jac5.2046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Ambulatory care pharmacists continue to expand their involvement in the management of various disease states across the United States, including anxiety and depression. There is limited literature assessing the clinical impact of these practice advances implemented by pharmacists who do not carry psychiatric training (i.e., psychiatric board certification or mental health training) within primary care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a retrospective, multicenter, cohort study of adult patients who had at least one documented visit between February 2020 and August 2023 with an ambulatory care pharmacist who did not carry additional psychiatric training to comanage their diagnosis of depression and/or anxiety. The primary outcome was the achievement of a therapeutic response (a reduction of 50% or greater in Patient Health Questionnaire 9-item depression scale [PHQ-9] and/or the Generalized Anxiety Disorder 7-item scale [GAD-7] scores). Secondary outcomes included the change in PHQ-9 and/or GAD-7 scores, incidence of remission, predictors of therapeutic response, pharmacist intervention subtypes, and percentage use of pharmacogenomics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Therapeutic response for PHQ-9 was achieved for 60 (48.4%) of 124 patients included after utilization of an ambulatory care pharmacist without additional psychiatric training embedded in primary care. While two-thirds of patients had comorbid anxiety, 43 (57.4%) could not be evaluated for clinical improvement as they did not have available GAD-7 scores for analysis. Available PHQ-9 and GAD-7 scores had median score reductions of 5 (−11,0) and 4.5 (−7.75, 3.5), respectively, at approximately 6 months (<i>p</i> &lt; 0.001 and <i>p</i> = 0.023). Patients had a median number of 4 (2, 5) visits with a pharmacist and a median number of 2 (1, 3) interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Ambulatory care pharmacists, regardless of additional psychiatric training, can help patients achieve a therapeutic response for depression and anxiety as well as significantly improve PHQ-9 and GAD-7 scores. Additional education on the importance of GAD-7 monitoring is warranted given its lack of routine collection and evaluation among patients presenting with comorbid depression and anxiety.</p>\u0000 </section>\u0000 </div>","PeriodicalId":73966,"journal":{"name":"Journal of the American College of Clinical Pharmacy : JACCP","volume":"7 12","pages":"1147-1153"},"PeriodicalIF":1.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of the American College of Clinical Pharmacy : JACCP
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