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Recent advances in proteomic analysis to study carotid artery plaques 研究颈动脉斑块的蛋白质组分析最新进展
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100215
Gabriel Cruz-González MD , James F. Meschia MD , Benjamin J. Madden BSc , Mercedes Prudencio PhD , Camilo A. Polania-Sandoval MD , Janelle Hartwell BS , Eniola Oyefeso BS , Ranya Benchaaboune , Tara Brigham MLIS , Sukhwinder J.S. Sandhu MD , Cristine Charlesworth PhD, MS , Ganesh P. Pujari MD , Leonard Petrucelli PhD , Akhilesh Pandey MD, PhD , Young Erben MD

Objective

We sought to identify differentially expressed proteins in serum, plasma, and plaque samples of patients with carotid atherosclerotic lesions.

Methods

We performed a systematic review of the proteomic profile of serum, plasma, and plaque samples of patients with carotid artery disease. We included full-length peer-reviewed studies of adult humans and reported them using PRISMA guidelines. The quality of the design and content of the articles included in the review was assessed using the Newcastle-Ottawa scale.

Results

We included six peer-reviewed articles reporting protein expression in serum, plasma, or plaque samples from patients with carotid atherosclerosis. Three were single-center cross-sectional studies, two were single-center case-control studies, and one was a single-center cohort study. Thirty-six proteins were found to be expressed differentially when comparing samples from healthy subjects and individuals with diseased carotid vessels and between patients with symptomatic and asymptomatic carotid artery atherosclerotic lesions. Some of these were shown to be related to inflammatory or anti-inflammatory pathways in atherogenesis. CD5L and S100A12 were both found to be upregulated in patients with unstable plaque, the former owing to its anti-inflammatory properties and the latter for its pro-oxidant effects in atherosclerosis. ACTB is involved in cellular structure and integrity and was found to be downregulated in patients with ruptured carotid plaques.

Conclusions

Atherosclerotic carotid disease places the patient at increased risk of ischemic neurological events. Proteomics may help to understand their pathophysiological processes and can identify differential protein expression in blood samples from healthy subjects and patients with carotid artery plaques. This patient-centered approach will allow for the timely identification of individuals at higher risk of experiencing stroke.

方法 我们对颈动脉疾病患者血清、血浆和斑块样本的蛋白质组学特征进行了系统性回顾。我们纳入了经同行评审的成人研究,并按照 PRISMA 指南进行了报告。我们采用纽卡斯尔-渥太华量表对纳入综述的文章的设计和内容质量进行了评估。结果我们纳入了六篇报道颈动脉粥样硬化患者血清、血浆或斑块样本中蛋白质表达的同行评议文章。其中三篇为单中心横断面研究,两篇为单中心病例对照研究,一篇为单中心队列研究。在比较健康受试者和颈动脉血管病变患者的样本以及有症状和无症状颈动脉粥样硬化病变患者的样本时,发现有 36 种蛋白质的表达存在差异。其中一些被证明与动脉粥样硬化发生过程中的炎症或抗炎途径有关。研究发现,CD5L和S100A12在不稳定斑块患者中均上调,前者是由于其抗炎特性,后者则是由于其在动脉粥样硬化中的促氧化作用。结论动脉粥样硬化性颈动脉疾病增加了患者发生缺血性神经事件的风险。蛋白质组学有助于了解其病理生理过程,并能识别健康人和颈动脉斑块患者血液样本中不同的蛋白质表达。这种以患者为中心的方法可以及时发现中风风险较高的人群。
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引用次数: 0
Basic Vascular Science 2024 Meeting 基础血管科学 2024 年会议
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100210
Thijs J. Sluiter MSc , Lucinda Cruddas MBBS , Federica Ninno MRes , Thomas Schmitz-Rixen MD, PhD , Janice Tsui MD, FRCS , Margreet R. de Vries PhD

The Basic Vascular Science (BVS) meeting was set up to provide a forum for researchers and clinicians in the field to exchange knowledge and ideas and to foster cross-disciplinary collaborations. The BVS 2024 meeting was held in Berlin. Attended by vascular surgeons and physicians, interventional radiologists, basic science researchers, and engineers, the meeting continues to successfully attract both early career researchers and established clinician-scientists. Here, we report on the scientific sessions encompassing keynote lectures and oral presentations.

基础血管科学(BVS)会议旨在为该领域的研究人员和临床医生提供一个交流知识和观点的论坛,并促进跨学科合作。BVS 2024 会议在柏林举行。血管外科医生和内科医生、介入放射科医生、基础科学研究人员和工程师参加了会议,会议继续成功地吸引了早期职业研究人员和成熟的临床科学家。在此,我们将报告包括主题演讲和口头报告在内的科学会议情况。
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引用次数: 0
Endothelial CEPT1 Impacts Aortic Atherosclerosis and Hepatic Lipoprotein Metabolism
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100234
Shahab Hafezi, Tariq J. Khan, Larisa Belaygorod, Batool Arif, Clay F. Semenkovich, Mohamed A. Zayed
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引用次数: 0
Tnfa-setdb2 Pathway Regulates Fibroblast to Myofibroblast Transition in Wound Repair
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100236
Tyler M. Bauer, Kevin Dale Mangum, Emily Barrett, James Shadiow, Amrita Joshi, Samuel Buckley, Frank Davis, Katherine A. Gallagher
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引用次数: 0
Genetic Variation Associated With Progression and Severity of Peripheral Artery Disease
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100237
Michael G. Levin, Shaunak Adkar, Jonas Ghouse, John Depaolo, Ole BV. Pedersen, Sisse Ostrowski, Julie Lynch, Henning Bundgaard, Scott M. Damrauer, Derek Klarin
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引用次数: 0
Soluble Guanylate Cyclase Activators as Potential Novel Pad Therapeutics
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100218
Shaunak Adkar, Sabina Sorondo, Mozhgan Lotfi, Sharika Bamezai, Ryan Choi, Ole Dyg Pedersen, Sisse Ostrowski, Jonas Ghouse, Henning Bundgaard, Michael Levin, Scott M. Damrauer, Nicholas J. Leeper, Derek Klarin
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引用次数: 0
Cofilin 1 Mediates Fatty Acid-Induced Foam Cell Formation And Inflammation In Mouse Bone Marrow-derived Macrophages
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100240
Jillian Poles, Lakshmi Arivazhagan, Vikas Kumar, Ann Marie Marie Schmidt
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引用次数: 0
Information for Readers
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/S2666-3503(24)00086-5
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引用次数: 0
Ultrasound elastography to quantify average percent pressure-normalized strain reduction associated with different aortic endografts in 3D-printed hydrogel phantoms 用超声弹性成像技术量化三维打印水凝胶模型中不同主动脉内移植物的平均压力归一化应变降低百分比
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100198
Dakota W. Gonring BA , Zachary R. Zottola BS , Adnan A. Hirad MD, PhD , Ronald Lakony BS , Michael S. Richards PhD , Grayson Pitcher MD , Michael C. Stoner MD , Doran S. Mix MD

Objective

Strain has become a viable index for evaluating abdominal aortic aneurysm stability after endovascular aneurysm repair (EVAR). In addition, literature has shown that healthy aortic tissue requires a degree of strain to maintain homeostasis. This has led to the hypothesis that too much strain reduction conferred by a high degree of graft oversizing is detrimental to the aneurysm neck in the seal zone of abdominal aortic aneurysms after EVAR. We investigated this in a laboratory experiment by examining the effects that graft oversizing has on the pressure-normalized strain (ερ+¯/pulse pressure [PP]) reduction using four different infrarenal EVAR endografts and our ultrasound elastography technique. Approximate graft oversizing percentages were 20% (30 mm phantom-graft combinations), 30% (28 mm phantom-graft combinations), and 50% (24 mm phantom-graft combinations).

Methods

Axisymmetric, 10% by mass polyvinyl alcohol phantoms were connected to a flow simulator. Ultrasound elastography was performed before and after implantation with the four different endografts: (1) 36 mm polyester/stainless steel, (2) 36 mm polyester/electropolished nitinol, (3) 35 mm polytetrafluoroethylene (PTFE)/nitinol, and (4) 36 mm nitinol/polyester/platinum-iridium. Five ultrasound cine loops were taken of each phantom-graft combination. They were analyzed over two different cardiac cycles (end-diastole to end-diastole), yielding a total of 10 maximum mean principal strain (ερ+¯) values. ερ+¯ was divided by pulse pressure to yield pressure-normalized strain (ερ+¯/PP). An analysis of variance was performed for graft comparisons. We calculated the average percent ερ+¯/PP reduction by manufacturer and percent oversizing. These values were used for linear regression analysis.

Results

Results from one-way analysis of variance showed a significant difference in ερ+¯/PP between the empty phantom condition and all oversizing conditions for all graft manufacturers (F(3, 56) = 106.7 [graft A], 132.7 [graft B], 106.5 [graft C], 105.7 [graft D], P < .0001 for grafts A-D). There was a significant difference when comparing the 50% condition with the 30% and 20% conditions across all manufacturers by post hoc a

目的应变已成为评估血管内动脉瘤修补术(EVAR)后腹主动脉瘤稳定性的可行指标。此外,文献显示,健康的主动脉组织需要一定程度的应变来维持平衡。这就导致了一种假设,即在 EVAR 后,移植物尺寸过大导致应变降低过多会对腹主动脉瘤密封区的瘤颈造成损害。我们在实验室实验中使用四种不同的肾下腔 EVAR 内移植物和超声弹性成像技术研究了移植物过大对压力归一化应变(ερ+¯/脉冲压力 [PP])降低的影响。移植物过大的百分比大约为 20%(30 毫米模型-移植物组合)、30%(28 毫米模型-移植物组合)和 50%(24 毫米模型-移植物组合)。在植入四种不同的内植物之前和之后进行超声弹性成像:(1) 36 毫米聚酯/不锈钢,(2) 36 毫米聚酯/电抛光镍钛诺,(3) 35 毫米聚四氟乙烯(PTFE)/镍钛诺,(4) 36 毫米镍钛诺/聚酯/铂铱。每个模型-移植物组合都拍摄了五个超声 cineops。对两个不同的心动周期(舒张末期到舒张末期)进行分析,共得出 10 个最大平均主应变(ερ+¯)值。ερ+¯除以脉压得出压力归一化应变(ερ+¯/PP)。对移植物比较进行方差分析。我们计算了各制造商的平均ερ+¯/PP 减少百分比和过大百分比。结果单因素方差分析结果显示,对于所有移植物制造商,在空模型条件和所有过大条件下,ερ+¯/PP 有显著差异(F(3, 56) = 106.7 [移植物 A]、132.7 [移植物 B]、106.5 [移植物 C]、105.7 [移植物 D],移植物 A-D 的 P < .0001)。通过事后分析,在所有制造商中,50% 条件与 30% 和 20% 条件相比有明显差异(P < .0001)。比较任何生产商的 20% 和 30% 过大条件,或根据过大百分比比较各生产商的 ερ+¯/PP 值,均未发现明显差异。线性回归显示移植物过大百分比与所有移植物平均ερ+¯/PP 减少百分比之间存在显著的正相关性(R2 = 0.84,P < .0001)。在临床应用中,这种增加可能会导致 EVAR 后轴对称血管的刚度增加。这是否具有临床意义还需要进一步研究。
{"title":"Ultrasound elastography to quantify average percent pressure-normalized strain reduction associated with different aortic endografts in 3D-printed hydrogel phantoms","authors":"Dakota W. Gonring BA ,&nbsp;Zachary R. Zottola BS ,&nbsp;Adnan A. Hirad MD, PhD ,&nbsp;Ronald Lakony BS ,&nbsp;Michael S. Richards PhD ,&nbsp;Grayson Pitcher MD ,&nbsp;Michael C. Stoner MD ,&nbsp;Doran S. Mix MD","doi":"10.1016/j.jvssci.2024.100198","DOIUrl":"10.1016/j.jvssci.2024.100198","url":null,"abstract":"<div><h3>Objective</h3><p>Strain has become a viable index for evaluating abdominal aortic aneurysm stability after endovascular aneurysm repair (EVAR). In addition, literature has shown that healthy aortic tissue requires a degree of strain to maintain homeostasis. This has led to the hypothesis that too much strain reduction conferred by a high degree of graft oversizing is detrimental to the aneurysm neck in the seal zone of abdominal aortic aneurysms after EVAR. We investigated this in a laboratory experiment by examining the effects that graft oversizing has on the pressure-normalized strain (<span><math><mrow><mover><msub><mi>ε</mi><mrow><mi>ρ</mi><mo>+</mo></mrow></msub><mo>¯</mo></mover></mrow></math></span>/pulse pressure [PP]) reduction using four different infrarenal EVAR endografts and our ultrasound elastography technique. Approximate graft oversizing percentages were 20% (30 mm phantom-graft combinations), 30% (28 mm phantom-graft combinations), and 50% (24 mm phantom-graft combinations).</p></div><div><h3>Methods</h3><p>Axisymmetric, 10% by mass polyvinyl alcohol phantoms were connected to a flow simulator. Ultrasound elastography was performed before and after implantation with the four different endografts: (1) 36 mm polyester/stainless steel, (2) 36 mm polyester/electropolished nitinol, (3) 35 mm polytetrafluoroethylene (PTFE)/nitinol, and (4) 36 mm nitinol/polyester/platinum-iridium. Five ultrasound cine loops were taken of each phantom-graft combination. They were analyzed over two different cardiac cycles (end-diastole to end-diastole), yielding a total of 10 maximum mean principal strain (<span><math><mrow><mover><msub><mi>ε</mi><mrow><mi>ρ</mi><mo>+</mo></mrow></msub><mo>¯</mo></mover></mrow></math></span>) values. <span><math><mrow><mover><msub><mi>ε</mi><mrow><mi>ρ</mi><mo>+</mo></mrow></msub><mo>¯</mo></mover></mrow></math></span> was divided by pulse pressure to yield pressure-normalized strain (<span><math><mrow><mover><msub><mi>ε</mi><mrow><mi>ρ</mi><mo>+</mo></mrow></msub><mo>¯</mo></mover></mrow></math></span>/PP). An analysis of variance was performed for graft comparisons. We calculated the average percent <span><math><mrow><mover><msub><mi>ε</mi><mrow><mi>ρ</mi><mo>+</mo></mrow></msub><mo>¯</mo></mover></mrow></math></span>/PP reduction by manufacturer and percent oversizing. These values were used for linear regression analysis.</p></div><div><h3>Results</h3><p>Results from one-way analysis of variance showed a significant difference in <span><math><mrow><mover><msub><mi>ε</mi><mrow><mi>ρ</mi><mo>+</mo></mrow></msub><mo>¯</mo></mover></mrow></math></span>/PP between the empty phantom condition and all oversizing conditions for all graft manufacturers (<em>F</em>(3, 56) = 106.7 [graft A], 132.7 [graft B], 106.5 [graft C], 105.7 [graft D], <em>P</em> &lt; .0001 for grafts A-D). There was a significant difference when comparing the 50% condition with the 30% and 20% conditions across all manufacturers by post hoc a","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000099/pdfft?md5=174462f0b3289da4a0f6e8331d8e0f44&pid=1-s2.0-S2666350324000099-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting future occlusion or stenosis of lower extremity bypass grafts using artificial intelligence to simultaneously analyze all flow velocities collected in current and previous ultrasound examinations 利用人工智能同时分析当前和以往超声检查中收集的所有血流速度,预测下肢旁路移植血管未来的闭塞或狭窄情况
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100192
Xiao Luo PhD , Fattah Muhammad Tahabi BS , Dave M. Rollins RVT , Alan P. Sawchuk MD

Objective

Routine surveillance with duplex ultrasound (DUS) examination is recommended after femoral-popliteal and femoral-tibial-pedal vein bypass grafts with various intervals postoperatively. The presently used methodology to analyze bypass graft DUS examination does not use all the available data and has been shown to have a significant rate for missing impending bypass graft failure. The objective of this research is to investigate recurrent neural networks (RNNs) to predict future bypass graft occlusion or stenosis.

Methods

This study includes DUS examinations of 663 patients who had bypass graft operations done between January 2009 and June 2022. Only examinations without missing values were included. We developed two RNNs (a bidirectional long short-term memory unit and a bidirectional gated recurrent unit) to predict bypass graft occlusion and stenosis based on peak systolic velocities collected in the 2 to 5 previous DUS examinations. We excluded the examinations with missing values and split our data into training and test sets. Then, we applied 10-fold cross-validation on training to optimize the hyperparameters and compared models using the test data.

Results

The bidirectional long short-term memory unit model can gain an overall sensitivity of 0.939, specificity of 0.963, and area under the curve of 0.950 on the prediction of bypass graft occlusion, and an overall sensitivity of 0.915, specificity of 0.909, and area under the curve of 0.912 predicting the development of a future critical stenosis. The results on different bypass types show that the system performs differently on different types. The results on subcohorts based on gender, smoking status, and comorbidities show that the performance on current smokers is lower than the never smoker.

Conclusions

We found that RNNs can gain good sensitivity, specificity, and accuracy for the detection of impending bypass graft occlusion or the future development of a critical bypass graft stenosis using all the available peak systolic velocity data in the present and previous bypass graft DUS examinations. Integrating clinical data, including demographics, social determinants, medication, and other risk factors, together with the DUS examination may result in further improvements.

Clinical Relevance

Detecting bypass graft failure before it occurs is important clinically to prevent amputations, salvage limbs, and save lives. Current methods evaluating screening duplex ultrasound examinations have a significant failure rate for detecting a bypass graft at risk for failure. Artificial intelligence using recurrent neural networks has the potential to improve the detection of at-risk bypass graft before they fail. Additionally, artificial intelligence is in the news and is being applied to many fields. Vascular surgeons need to know its potential to improve vascular outcomes.

目的建议在股-腘静脉和股-胫-腓静脉旁路移植术后的不同时间间隔内使用双工超声(DUS)进行常规监测。目前使用的旁路移植术 DUS 检查分析方法并未使用所有可用数据,而且已被证明有很大可能遗漏即将发生的旁路移植术失败。本研究的目的是研究用递归神经网络(RNN)来预测未来旁路移植管闭塞或狭窄的情况。方法本研究包括对 2009 年 1 月至 2022 年 6 月间接受旁路移植手术的 663 名患者进行的 DUS 检查。仅纳入了无缺失值的检查。我们开发了两个 RNN(双向长短期记忆单元和双向门控复发单元),根据之前 2 到 5 次 DUS 检查中收集的收缩速度峰值预测旁路移植闭塞和狭窄。我们排除了有缺失值的检查,并将数据分成训练集和测试集。结果双向长短期记忆单元模型在预测旁路移植闭塞方面的总体灵敏度为 0.939,特异性为 0.963,曲线下面积为 0.950;在预测未来发生临界狭窄方面的总体灵敏度为 0.915,特异性为 0.909,曲线下面积为 0.912。不同分流类型的结果表明,该系统对不同类型的分流有不同的表现。基于性别、吸烟状况和合并症的亚群结果显示,当前吸烟者的表现低于从未吸烟者。结论我们发现,RNN 可以利用当前和之前旁路移植 DUS 检查中所有可用的收缩压峰值速度数据,获得良好的灵敏度、特异性和准确性,用于检测即将发生的旁路移植闭塞或未来发展为临界旁路移植狭窄。将临床数据(包括人口统计学、社会决定因素、药物和其他风险因素)与 DUS 检查结合起来可能会带来进一步的改进。临床意义在旁路移植失败发生之前进行检测对于防止截肢、抢救肢体和挽救生命具有重要的临床意义。目前评估筛查双相超声检查的方法在检测有失效风险的旁路移植方面有很大的失败率。使用递归神经网络的人工智能有可能在搭桥术失败前提高对高风险搭桥术的检测率。此外,人工智能已成为新闻,并被应用于许多领域。血管外科医生需要了解人工智能在改善血管治疗效果方面的潜力。
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引用次数: 0
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JVS-vascular science
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