Pub Date : 2018-06-12DOI: 10.21037/NCRI.2018.11.08
R. Donato
Over the past two decades a great deal of information has been provided concerning myogenesis—the process of skeletal muscle formation. Much is known about the cellular and molecular mechanisms of adult myogenesis—the process through which adult muscle regenerates following acute injury and embryonic myogenesis—the process of skeletal muscle tissue development (1,2); however, the picture of the molecular mechanisms governing myogenesis is far from being complete. A recent paper by Mok et al. (3) adds an important piece of information to the mosaic of molecules/factors driving the ordered sequence of muscle-related events leading to cell fate decisions in developing embryos.
{"title":"Sonic hedgehog-regulated myotome formation relies on the myomiR, miR-133","authors":"R. Donato","doi":"10.21037/NCRI.2018.11.08","DOIUrl":"https://doi.org/10.21037/NCRI.2018.11.08","url":null,"abstract":"Over the past two decades a great deal of information has been provided concerning myogenesis—the process of skeletal muscle formation. Much is known about the cellular and molecular mechanisms of adult myogenesis—the process through which adult muscle regenerates following acute injury and embryonic myogenesis—the process of skeletal muscle tissue development (1,2); however, the picture of the molecular mechanisms governing myogenesis is far from being complete. A recent paper by Mok et al. (3) adds an important piece of information to the mosaic of molecules/factors driving the ordered sequence of muscle-related events leading to cell fate decisions in developing embryos.","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45957229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-12DOI: 10.21037/NCRI.2018.11.02
Debojyoti Das, A. Das, A. Panda
The advent of high-throughput genomic technologies revealed the expression of thousands of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in human. Both classes of RNAs have limited or no protein coding potential. Both lncRNAs and circRNAs regulates gene expression by interacting with target DNA, RNA or proteins. Accumulating studies have demonstrated that lncRNAs and circRNAs play important role in various human diseases, including diabetes. Pancreatic β cell function is at the core of development of diabetes. This review will highlight the present knowledge about the role of lncRNAs and circRNAs in pancreatic β cell function and their association with development of diabetes.
{"title":"Emerging role of long noncoding RNAs and circular RNAs in pancreatic β cells","authors":"Debojyoti Das, A. Das, A. Panda","doi":"10.21037/NCRI.2018.11.02","DOIUrl":"https://doi.org/10.21037/NCRI.2018.11.02","url":null,"abstract":"The advent of high-throughput genomic technologies revealed the expression of thousands of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in human. Both classes of RNAs have limited or no protein coding potential. Both lncRNAs and circRNAs regulates gene expression by interacting with target DNA, RNA or proteins. Accumulating studies have demonstrated that lncRNAs and circRNAs play important role in various human diseases, including diabetes. Pancreatic β cell function is at the core of development of diabetes. This review will highlight the present knowledge about the role of lncRNAs and circRNAs in pancreatic β cell function and their association with development of diabetes.","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/NCRI.2018.11.02","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45507308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-08DOI: 10.21037/ALES.2018.07.07
M. Stamos, Matthew T. Brady
Anastomotic leak is one of the most fretted complications in colon and rectal surgery and its occurrence carries a significant degree of morbidity and mortality for affected patients. Given the degree of harm this complication causes patients, a significant amount of work has been done in the field to identify factors associated with anastomotic leak in an effort to minimize both its occurrence and associated morbidity.
{"title":"Anastomotic leak: are we closer to eliminating its occurrence?","authors":"M. Stamos, Matthew T. Brady","doi":"10.21037/ALES.2018.07.07","DOIUrl":"https://doi.org/10.21037/ALES.2018.07.07","url":null,"abstract":"Anastomotic leak is one of the most fretted complications in colon and rectal surgery and its occurrence carries a significant degree of morbidity and mortality for affected patients. Given the degree of harm this complication causes patients, a significant amount of work has been done in the field to identify factors associated with anastomotic leak in an effort to minimize both its occurrence and associated morbidity.","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43598985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01Epub Date: 2018-06-26DOI: 10.21037/ncri.2018.06.05
Maxine Umeh-Garcia, Colleen Sweeney
{"title":"Cancer prevention through miRNAs: miR-206 prevents the initiation and progression of hepatocellular carcinoma by attenuating c-MET signaling and cell-cycle progression via cyclin D1 and CDK6.","authors":"Maxine Umeh-Garcia, Colleen Sweeney","doi":"10.21037/ncri.2018.06.05","DOIUrl":"https://doi.org/10.21037/ncri.2018.06.05","url":null,"abstract":"","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.06.05","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37536191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01Epub Date: 2018-06-14DOI: 10.21037/ncri.2018.05.06
Amaresh C Panda, Myriam Gorospe
In an insightful editorial (1), Bogard and colleagues discussed a recent publication from our laboratory describing the method ‘RNase R treatment followed by Polyadenylation and poly(A) + RNA Depletion’ (RPAD) to isolate highly enriched circular RNAs (circRNAs) from heterogeneous total RNA pools (2).
{"title":"Identifying intronic circRNAs: progress and challenges.","authors":"Amaresh C Panda, Myriam Gorospe","doi":"10.21037/ncri.2018.05.06","DOIUrl":"https://doi.org/10.21037/ncri.2018.05.06","url":null,"abstract":"In an insightful editorial (1), Bogard and colleagues discussed a recent publication from our laboratory describing the method ‘RNase R treatment followed by Polyadenylation and poly(A) + RNA Depletion’ (RPAD) to isolate highly enriched circular RNAs (circRNAs) from heterogeneous total RNA pools (2).","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.05.06","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36430378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-01Epub Date: 2018-05-06DOI: 10.21037/ncri.2018.04.05
Carmit Levy, Tamar Golan, David E Fisher
The endoplasmic reticulum (ER) is an essential mediator of cellular homeostasis and stress responses; it influences secreted protein synthesis, post-translation modification, and peptide folding (1).
{"title":"miRNA-211 stops the clock.","authors":"Carmit Levy, Tamar Golan, David E Fisher","doi":"10.21037/ncri.2018.04.05","DOIUrl":"https://doi.org/10.21037/ncri.2018.04.05","url":null,"abstract":"The endoplasmic reticulum (ER) is an essential mediator of cellular homeostasis and stress responses; it influences secreted protein synthesis, post-translation modification, and peptide folding (1).","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.04.05","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36477162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-01Epub Date: 2018-04-20DOI: 10.21037/ncri.2018.04.02
Tatsuya Aonuma, Ahmed S Bayoumi, Yaoliang Tang, Il-Man Kim
{"title":"A circular RNA regulator quaking: a novel gold mine to be unfolded in doxorubicin-mediated cardiotoxicity.","authors":"Tatsuya Aonuma, Ahmed S Bayoumi, Yaoliang Tang, Il-Man Kim","doi":"10.21037/ncri.2018.04.02","DOIUrl":"10.21037/ncri.2018.04.02","url":null,"abstract":"","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108587/pdf/nihms-984835.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36430380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-01Epub Date: 2018-04-23DOI: 10.21037/ncri.2018.03.08
Abdalla Akef, Stefan A Muljo
Roquin-1 and Roquin-2 are RNA-binding proteins essential for modulating T cell activity. Indeed, Roquin dysfunction has been linked to autoimmunity in mice. Essig and colleagues (2017) determine their functions in Foxp3+ T regulatory cells and uncover novel mechanisms of Roquin-mediated regulation of its target mRNAs (1).
{"title":"How T cells go rogue in the absence of Roquins.","authors":"Abdalla Akef, Stefan A Muljo","doi":"10.21037/ncri.2018.03.08","DOIUrl":"https://doi.org/10.21037/ncri.2018.03.08","url":null,"abstract":"<p><p>Roquin-1 and Roquin-2 are RNA-binding proteins essential for modulating T cell activity. Indeed, Roquin dysfunction has been linked to autoimmunity in mice. Essig and colleagues (2017) determine their functions in Foxp3<sup>+</sup> T regulatory cells and uncover novel mechanisms of Roquin-mediated regulation of its target mRNAs (1).</p>","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.03.08","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36131123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-12DOI: 10.21037/ncri.2018.11.06
L. Xia, Meiyi Song, Fei Wang
As a class of endogenous non-coding RNA expressed by regulatory genes, circular RNAs (circRNAs) have attracted widespread attention due to their unique closed-loop structure. CircRNAs can not only exist stably in different tissues and organs, but also widely exist in blood, exocrine, lymph, saliva and other body fluids. They are involved in the regulation of embryonic development, aging and many pathophysiological processes related to various diseases. Recently, the diagnosis and treatment of digestive diseases have made great advances due to the rapid development of fundamental research. However, most diseases are still lack of accurate early diagnosis and miss the best treatment opportunity, the concomitant complications seriously endanger human health and even lead to death. With the circRNAs becoming a hot research spot, the roles of circRNAs in digestive diseases have also been confirmed and recognized. This review mainly introduces the biological characteristics of circRNAs and their association with digestive diseases, expecting to contribute to the future research on digestive diseases and the exploration of circRNAs function.
{"title":"Circular RNAs: a novel tool in the development of digestive system biomarker","authors":"L. Xia, Meiyi Song, Fei Wang","doi":"10.21037/ncri.2018.11.06","DOIUrl":"https://doi.org/10.21037/ncri.2018.11.06","url":null,"abstract":"As a class of endogenous non-coding RNA expressed by regulatory genes, circular RNAs (circRNAs) have attracted widespread attention due to their unique closed-loop structure. CircRNAs can not only exist stably in different tissues and organs, but also widely exist in blood, exocrine, lymph, saliva and other body fluids. They are involved in the regulation of embryonic development, aging and many pathophysiological processes related to various diseases. Recently, the diagnosis and treatment of digestive diseases have made great advances due to the rapid development of fundamental research. However, most diseases are still lack of accurate early diagnosis and miss the best treatment opportunity, the concomitant complications seriously endanger human health and even lead to death. With the circRNAs becoming a hot research spot, the roles of circRNAs in digestive diseases have also been confirmed and recognized. This review mainly introduces the biological characteristics of circRNAs and their association with digestive diseases, expecting to contribute to the future research on digestive diseases and the exploration of circRNAs function.","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.11.06","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47334310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-01Epub Date: 2018-03-07DOI: 10.21037/ncri.2018.02.03
Danielle A Jeffrey, Carmen C Sucharov
Cardiovascular disease is a major contributor of adult mortality and accounts for approximately 801,000 deaths annually throughout the United States alone (1).
{"title":"CELF1 regulates gap junction integrity contributing to dilated cardiomyopathy.","authors":"Danielle A Jeffrey, Carmen C Sucharov","doi":"10.21037/ncri.2018.02.03","DOIUrl":"https://doi.org/10.21037/ncri.2018.02.03","url":null,"abstract":"Cardiovascular disease is a major contributor of adult mortality and accounts for approximately 801,000 deaths annually throughout the United States alone (1).","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.02.03","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36477164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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