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Injectable and tissue-conformable conductive hydrogel for MRI-compatible brain-interfacing electrodes 用于mri兼容脑接口电极的可注射和组织适应的导电水凝胶
Pub Date : 2023-01-01 DOI: 10.20517/ss.2023.08
Song Dong Kim, Kyuha Park, Sungjun Lee, Jeungeun Kum, Yewon Kim, Soojung An, Hyungmin Kim, M. Shin, Donghee Son
The development of flexible and stretchable materials has led to advances in implantable bio-integrated electronic devices that can sense physiological signals or deliver electrical stimulation to various organs in the human body. Such devices are particularly useful for neural interfacing systems that monitor neurodegenerative diseases such as Parkinson’s disease or epilepsy in real time. However, coupling current brain-interfacing devices with magnetic resonance imaging (MRI) remains a practical challenge due to resonance frequency variations from inorganic metal-based devices. Thus, organic conductive materials, such as poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS), have recently been considered as promising candidates. Nonetheless, their conformability on curvilinear tissues remains questionable. In this study, we developed an injectable conductive hydrogel (ICH) composed of tyramine-conjugated hyaluronic acid (HATYR) and PEDOT:PSS for MRI-compatible brain-interfacing electrodes. Our ICH produced low impedance around 5 kΩ even under 10 Hz, demonstrating high confidence volumetric capacitance. Due to HATYR’s biocompatibility, histological and cytotoxicity assays showed almost no inflammation and toxicity, respectively; in addition, ICH was able to degrade into 40% of its original volume within four weeks in vivo. An electrocorticogram (ECoG) array was also patternable by syringe injections of ICH on a stretchable and flexible elastomeric substrate layer that conformed to curvy brain tissues and successfully recorded ECoG signals under light stimulation. Furthermore, MRI imaging of implanted devices did not show any artifacts, indicating the potential of the MRI-compatible hydrogel electrodes for advanced ECoG arrays. This study provides a promising solution for MRI-compatible neural electrodes, enabling the advancement of chronic neural interfacing systems for monitoring neurodegenerative diseases.
柔性和可拉伸材料的发展导致了植入式生物集成电子设备的进步,这些设备可以感知生理信号或向人体各器官传递电刺激。这种设备对于实时监测神经退行性疾病(如帕金森病或癫痫)的神经接口系统特别有用。然而,由于无机金属基设备的共振频率变化,将当前的脑接口设备与磁共振成像(MRI)耦合仍然是一个实际的挑战。因此,有机导电材料,如聚(3,4-乙烯二氧噻吩)-聚苯乙烯磺酸盐(PEDOT:PSS),最近被认为是有前途的候选者。尽管如此,它们在曲线组织上的顺应性仍然值得怀疑。在这项研究中,我们开发了一种由酪胺偶联透明质酸(HATYR)和PEDOT:PSS组成的可注射导电水凝胶(ICH),用于mri兼容的脑接口电极。我们的ICH即使在10 Hz以下也能产生5 kΩ左右的低阻抗,显示出高置信度的体积电容。由于HATYR的生物相容性,组织学和细胞毒性试验分别显示几乎没有炎症和毒性;此外,ICH能够在体内4周内降解为原始体积的40%。脑皮质电图(ECoG)阵列也可以通过注射器将ICH注射到符合弯曲脑组织的可拉伸和柔性弹性衬底层上,并成功记录光刺激下的ECoG信号。此外,植入设备的MRI成像未显示任何伪影,表明MRI兼容水凝胶电极用于先进的ECoG阵列的潜力。这项研究为mri兼容的神经电极提供了一个有希望的解决方案,使监测神经退行性疾病的慢性神经接口系统的进步成为可能。
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引用次数: 0
Organic biodegradable piezoelectric materials and their potential applications as bioelectronics 有机可生物降解压电材料及其在生物电子学方面的潜在应用
Pub Date : 2023-01-01 DOI: 10.20517/ss.2022.30
Fanqi Dai, Qifan Geng, Ting Hua, Xing Sheng, Lan Yin, Prof. Lan Yin
biodegradable piezoelectric materials and their potential
可生物降解的压电材料及其潜力
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引用次数: 1
Stretchable flexible sensors for smart tires based on laser-induced graphene technology 基于激光诱导石墨烯技术的智能轮胎可伸缩柔性传感器
Pub Date : 2023-01-01 DOI: 10.20517/ss.2023.02
Yang Yue, Xuyang Li, Zifeng Zhao, Hao Wang, Xiaogang Guo
Continuous feedback on a tire is an essential means to ensure tire safety. Smart tires are an important part of the future vehicle control system, which affects the safety and comfort of vehicles by combining sensors with traditional tires to achieve continuous monitoring of real-time dynamic parameters. A stretchable and flexible sensor made of laser-induced graphene (LIG) and PDMS, designed for use in smart tires, is presented in this work. The sensor is known as a LIG-PDMS sensor. Using transfer printing, LIG is formed on a commercial polyimide film under the scribing of a laser beam following the predesigned route before being transferred to a PDMS film. This technology is used to successfully prepare flexible sensors for measuring the tire road interaction at different driving speeds due to its flexibility and shape-following characteristics. The real-time monitoring of the wheel speed and the shape of the tire grounding mark during the driving process is realized by embedding multiple LIG sensors in the tire to monitor the strain information of the tire grounding. Results show that the tire deformation can be accurately feedbacked with the LIG sensors, demonstrating our method's capability for designing and manufacturing intelligent tires.
轮胎的持续反馈是保证轮胎安全的重要手段。智能轮胎是未来车辆控制系统的重要组成部分,它通过将传感器与传统轮胎相结合,实现对车辆实时动态参数的连续监测,影响车辆的安全性和舒适性。本文介绍了一种由激光诱导石墨烯(LIG)和PDMS制成的可伸缩柔性传感器,设计用于智能轮胎。该传感器被称为ligi - pdms传感器。使用转移印刷,LIG在商业聚酰亚胺薄膜上形成,在激光束按照预先设计的路线划线,然后转移到PDMS薄膜上。该技术由于其灵活性和形状跟随特性,成功制备了柔性传感器,用于测量轮胎在不同行驶速度下的路面相互作用。通过在轮胎中嵌入多个LIG传感器,监测轮胎接地的应变信息,实现对行驶过程中车轮转速和轮胎接地痕迹形状的实时监测。结果表明,利用LIG传感器可以准确地反馈轮胎变形,证明了该方法在设计和制造智能轮胎方面的能力。
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引用次数: 0
Hair-compatible sponge electrodes integrated on VR headset for electroencephalography 与头发兼容的海绵电极集成在VR头显上用于脑电图
Pub Date : 2023-01-01 DOI: 10.20517/ss.2023.11
Hongbian Li, Hyonyoung Shin, Min Zhang, Andrew Yu, Heeyong Huh, Gubeum Kwon, Nicholas J. Riveira, Sangjun Kim, Susmita Gangopadahyay, Jessie Peng, Zhengjie Li, Yifan Rao, L. Sentis, J. Millán, N. Lu
Virtual reality (VR) technology has emerged as a promising tool for brain-computer interaction and neuroscience research due to its ability to provide immersive and interactive experiences for its users. As a powerful tool to noninvasively monitor the cortex, electroencephalography (EEG) combined with VR represents an exciting opportunity for the measurement of brain activity during these experiences, providing insight into cognitive and neural processes. However, traditional gel-based EEG sensors are not compatible with VR headsets, and most emerging VR-EEG headsets utilizing rigid comb electrodes are uncomfortable after prolonged wear. To address this limitation, we created soft, porous, and hair-compatible sponge electrodes based on conductive poly(3,4-ethylenedioxythiophene) polystyrene sulfonate/melamine (PMA) and integrated them onto a VR headset through a customized, flexible circuit for multichannel EEG during VR task performing. Our PMA sponge electrodes can deform to make contact with the scalp skin through hairs under the pressure naturally applied by the strap of the VR headset. The specific contact impedance was consistently below 80 kΩ·cm2, even at hairy sites. We demonstrated the capability of our VR-EEG headset by recording alpha rhythms during eye closure at both hairless and hairy sites. In another demonstration, we developed a VR task to evoke the contingent negative variation potential and achieved a classification accuracy of 0.66 ± 0.07, represented by the cross-validated area under the receiver operating characteristic curve. Our sponge-electrode-integrated VR headset is user-friendly and easy to set up, marking a step toward future reliable, comfortable, and reusable VR-EEG technology.
虚拟现实(VR)技术已经成为脑机交互和神经科学研究的一个有前途的工具,因为它能够为用户提供身临其境的互动体验。作为一种无创监测皮质的强大工具,脑电图(EEG)与VR相结合,为测量这些体验中的大脑活动提供了一个令人兴奋的机会,提供了对认知和神经过程的洞察。然而,传统的凝胶型脑电图传感器与VR头戴设备并不兼容,大多数新兴的VR-EEG头戴设备使用刚性梳状电极,长时间佩戴后不舒服。为了解决这一限制,我们基于导电聚(3,4-乙烯二氧噻吩)聚苯乙烯磺酸/三聚氰胺(PMA)制造了柔软、多孔、与头发兼容的海绵电极,并通过定制的柔性电路将其集成到VR头戴设备上,用于VR任务执行期间的多通道EEG。我们的PMA海绵电极可以在VR头显带自然施加的压力下变形,通过头发与头皮皮肤接触。即使在毛状部位,比接触阻抗也始终低于80 kΩ·cm2。我们通过记录无毛和有毛部位闭眼时的α节律,展示了VR-EEG耳机的功能。在另一个演示中,我们开发了一个VR任务来唤起偶然的负变异电位,并获得了0.66±0.07的分类精度,由接收者工作特征曲线下的交叉验证面积表示。我们的海绵电极集成VR头显用户友好且易于设置,标志着向未来可靠,舒适和可重复使用的VR- eeg技术迈出了一步。
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引用次数: 1
Progress on flexible tactile sensors in robotic applications on objects properties recognition, manipulation and human-machine interactions 柔性触觉传感器在机器人物体属性识别、操作和人机交互中的应用进展
Pub Date : 2023-01-01 DOI: 10.20517/ss.2022.34
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引用次数: 0
A comprehensive survey of ionic polymer metal composite transducers: preparation, performance optimization and applications 离子聚合物金属复合换能器:制备、性能优化及应用综述
Pub Date : 2023-01-01 DOI: 10.20517/ss.2023.01
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引用次数: 2
Recent progress in soft electronics and robotics based on magnetic nanomaterials 基于磁性纳米材料的软电子和机器人技术的最新进展
Pub Date : 2023-01-01 DOI: 10.20517/ss.2023.05
Xiang Lin, Mengdi Han
Recent advancements in soft electronics and robotics have expanded the possibilities beyond the capabilities of traditional rigid devices, indicating promise for a range of applications in electronic skins, wireless biomedical devices, and others. Magnetic materials exploited in these soft systems can further broaden the modalities in sensing and actuation. These magnetic materials, when constructed in the forms of nanoparticles, nanomembranes, or other types of nanostructures, exhibit some unique characteristics, such as the magnetoresistance effect and size-dependent coercivity. Soft electronics and robotics employing such magnetic nanomaterials offer a variety of functions, including the detection of the intensity and direction of magnetic fields, measurement of various types of mechanical deformations, manipulation and transport at small scales, and multimodal complex locomotion in a controllable fashion. Despite recent advancements in soft electronics and robotics, challenges remain in developing advanced materials and manufacturing schemes to improve performance metrics and facilitate integration with other devices. This review article aims to summarize the progress made in soft electronics and robotics based on magnetic nanomaterials, with an emphasis on introducing material and device performance. The discussions focus on soft electronics and robotics based on magnetic nanomembranes/nanostructures and magnetic composites. As a concluding remark, this article summarizes the current status of the field and discusses opportunities that underpin future progress.
软电子和机器人技术的最新进展已经扩展了传统刚性设备的能力之外的可能性,表明了在电子皮肤,无线生物医学设备等方面的一系列应用前景。在这些软系统中开发的磁性材料可以进一步拓宽传感和驱动的模式。这些磁性材料,当以纳米颗粒、纳米膜或其他类型的纳米结构的形式构建时,表现出一些独特的特性,如磁电阻效应和尺寸相关的矫顽力。采用这种磁性纳米材料的软电子和机器人技术提供了多种功能,包括检测磁场的强度和方向,测量各种类型的机械变形,在小尺度上操纵和运输,以及以可控的方式进行多模态复杂运动。尽管最近软电子和机器人技术取得了进步,但在开发先进材料和制造方案以提高性能指标并促进与其他设备的集成方面仍然存在挑战。本文综述了磁性纳米材料在软电子和机器人领域的研究进展,重点介绍了磁性纳米材料及其器件的性能。讨论的重点是基于磁性纳米膜/纳米结构和磁性复合材料的软电子和机器人技术。作为结束语,本文总结了该领域的现状,并讨论了支持未来进展的机会。
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引用次数: 0
A lamellar-ordered poly[bi(3,4-ethylenedioxythiophene)-alt-thienyl] for efficient tuning of thermopower without degenerated conductivity 一种层状有序聚[双(3,4-乙基二氧噻吩)-邻噻吩],用于有效调节热功率而不使电导率退化
Pub Date : 2023-01-01 DOI: 10.20517/ss.2023.10
L. Shen, Meng-ting Liu, Peipei Liu, Jingkun Xu, N. Li, Zhiliang Wan, Zhihong Chen, Cong-cong Liu, Weiqiang Zhou, Yu-Jie Liang, F. Jiang
Modulating the structural order of conjugated polymers has emerged as a significant approach to enhance the organic thermoelectric performance. Among these materials, poly(3,4-ethylenedioxythiophene) is considered a promising candidate due to its high conductivity. However, its low thermopower remains a major obstacle to further improve its performance as an organic thermoelectric material. To address this issue, a series of thiophene derivatives with high rigidity and containing dioxyethylene groups were synthesized, and polymer films were prepared through a simple and mild in-situ polymerization method. The polymer molecule containing a thiophene block, named poly[bi(3,4-ethylenedioxy)-alt-thienyl] , exhibits significant self-rigidification due to non-covalent interactions between oxygen and sulfur atoms, resulting in highly ordered assembly. By adding thiophene and thieno[3,2-b]thiophene structures to the intermediate precursor bi(3,4-ethylenedioxy), the 3,4-ethylenedioxy content in the polymer molecule is altered, leading to an almost four-fold increase in the thermopower of the thin film polymer and achieving a maximum thermopower of around 26 μV·K-1. Although poly[bi(3,4-ethylenedioxy)-alt-thienyl] shows a significant increase in thermopower compared to poly[bi(3,4-ethylenedioxy)], the thin film conductivity exhibits a nearly imperceptible decreasing trend due to its highly ordered microstructure. This work highlights the potential to control the aggregation state of polymer molecules and achieve an approximate decoupling between the conductivity and thermopower of thermoelectric materials by rationally designing polymer molecules.
调制共轭聚合物的结构顺序已成为提高有机热电性能的重要途径。在这些材料中,聚(3,4-乙烯二氧噻吩)由于其高导电性被认为是一个有前途的候选材料。然而,它的低热功率仍然是进一步提高其作为有机热电材料性能的主要障碍。为了解决这一问题,我们合成了一系列高刚性、含二氧乙烯基的噻吩衍生物,并通过简单温和的原位聚合法制备了聚合物薄膜。含有噻吩嵌段的聚合物分子被命名为聚[双(3,4-乙烯二氧基)-硫基],由于氧和硫原子之间的非共价相互作用,表现出显著的自刚性,导致高度有序的组装。通过在中间前驱体双(3,4-乙烯二氧基)中加入噻吩和噻吩[3,2-b]结构,改变了聚合物分子中的3,4-乙烯二氧基含量,使薄膜聚合物的热功率提高了近4倍,最大热功率约为26 μV·K-1。虽然与聚[双(3,4-乙烯二氧基)-硫代基]相比,聚[双(3,4-乙烯二氧基)-硫代基]表现出显著的热功率增加,但由于其高度有序的微观结构,其薄膜电导率呈现出几乎难以察觉的下降趋势。这项工作强调了通过合理设计聚合物分子来控制聚合物分子的聚集状态和实现热电材料的电导率和热功率的近似解耦的潜力。
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引用次数: 0
Recent progress in thermal management for flexible/wearable devices 柔性/可穿戴设备热管理的最新进展
Pub Date : 2023-01-01 DOI: 10.20517/ss.2023.04
J. Yun
Thermal management for wearable devices is evolving to make ubiquitous applications possible based on advanced devices featuring miniaturization, integration, and ultrathin designs. Thermal management and control integrated with wearable devices are highly desirable for various applications for human body monitoring, including external heat exposure and metabolic heat generation, in various activities. Recently, dynamic change materials have been integrated with micro/nano thermal management platforms to address the potential for active thermal management. In this article, recent advances in the architecture of effective thermal management in wearable devices are reviewed, along with the essential mechanisms for managing thermal conditions for users in external/internal thermal environments. Appropriate thermal management approaches are proposed for the design and integration of materials/structures tailored to specific targets in wearable devices. In particular, this review is devoted to materials/structures based on five thermal management strategies: conduction, radiation, evaporation/convection, heat absorption/release, and thermoelectric (TE). Finally, the challenges and prospects for practical applications of thermal management in wearable devices are discussed.
基于小型化、集成化和超薄设计的先进设备,可穿戴设备的热管理正在不断发展,使无处不在的应用成为可能。与可穿戴设备集成的热管理和控制非常适合各种人体监测应用,包括各种活动中的外部热暴露和代谢热产生。最近,动态变化材料已与微/纳米热管理平台集成,以解决主动热管理的潜力。本文回顾了可穿戴设备中有效热管理架构的最新进展,以及在外部/内部热环境中管理用户热条件的基本机制。提出了适合可穿戴设备中特定目标的材料/结构的设计和集成的适当热管理方法。本文特别介绍了基于五种热管理策略的材料/结构:传导、辐射、蒸发/对流、热吸收/释放和热电(TE)。最后,讨论了热管理在可穿戴设备中的实际应用所面临的挑战和前景。
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引用次数: 2
Challenges and progress of chemical modification in piezoelectric composites and their applications 压电复合材料化学改性及其应用的挑战与进展
Pub Date : 2023-01-01 DOI: 10.20517/ss.2022.33
Weiwei Zhang, Yanhu Zhang, Xiaodong Yan, Ying Hong, Zhengbao Yang
Piezoelectric materials directly convert energy between electrical and mechanical domains, and have been widely employed in electronic devices as sensors and energy harvesters. Recent research endeavors are mainly devoted to dealing with problems such as high stiffness, brittleness, toxicity, poor durability, and low piezoelectric coefficients. Among developed strategies, chemical modification captures much attention. However, the exact physical properties and direct experimental evidence of chemical modification remain elusive or controversial thus far. In this review, we discuss the recently developed piezoelectric modification strategies for piezoelectric composites and assess the effect of different chemical modification approaches on piezoelectric properties. Moreover, we outline existing challenges and new applications of piezoelectric composites.
压电材料直接在电气和机械领域之间转换能量,已广泛应用于传感器和能量收集器等电子设备中。近年来的研究主要集中在高刚度、高脆性、高毒性、低耐久性和低压电系数等问题上。在已开发的策略中,化学改性备受关注。然而,到目前为止,化学改性的确切物理性质和直接实验证据仍然难以捉摸或有争议。在本文中,我们讨论了近年来发展的压电改性策略,并评估了不同的化学改性方法对压电材料性能的影响。此外,我们概述了压电复合材料存在的挑战和新的应用。
{"title":"Challenges and progress of chemical modification in piezoelectric composites and their applications","authors":"Weiwei Zhang, Yanhu Zhang, Xiaodong Yan, Ying Hong, Zhengbao Yang","doi":"10.20517/ss.2022.33","DOIUrl":"https://doi.org/10.20517/ss.2022.33","url":null,"abstract":"Piezoelectric materials directly convert energy between electrical and mechanical domains, and have been widely employed in electronic devices as sensors and energy harvesters. Recent research endeavors are mainly devoted to dealing with problems such as high stiffness, brittleness, toxicity, poor durability, and low piezoelectric coefficients. Among developed strategies, chemical modification captures much attention. However, the exact physical properties and direct experimental evidence of chemical modification remain elusive or controversial thus far. In this review, we discuss the recently developed piezoelectric modification strategies for piezoelectric composites and assess the effect of different chemical modification approaches on piezoelectric properties. Moreover, we outline existing challenges and new applications of piezoelectric composites.","PeriodicalId":74837,"journal":{"name":"Soft science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67660352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Soft science
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