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A skin-wearable and self-powered laminated pressure sensor based on triboelectric nanogenerator for monitoring human motion 基于三电纳米发电机的皮肤可穿戴自供电层压传感器,用于监测人体运动
Pub Date : 2024-01-26 DOI: 10.20517/ss.2023.54
Agha Aamir Jan, Seungbeom Kim, Seok Kim
Flexible and skin-wearable triboelectric nanogenerators (TENGs) have emerged as promising candidates for self-powered tactile and pressure sensors and mechanical energy harvesters due to their compatible design and ability to operate at low frequencies. Most research has focused on improving tribo-negative materials for flexible TENGs, given the limited options for tribo-positive materials. Achieving biocompatibility while maintaining the sensitivity and capability of energy harvesting is another critical issue for wearable sensors. Here, we report a TENG-based biocompatible and self-powered pressure sensor by simple fabrication of layer-by-layer deposition methods. The Laminated Flexible-TENG comprises polytetrafluoroethylene (PTFE) and polymethyl methacrylate (PMMA) films embedded within a flexible and biocompatible polydimethylsiloxane (PDMS) matrix. A nanostructured PDMS surface obtained by oxygen plasma facilitated the sputter deposition of a layered indium tin oxide copper electrode and a tribo-positive PMMA thin layer on top. The addition of the indium tin oxide layer to copper significantly improved the quality and performance of the indium tin oxide-copper electrode. Self-powered Laminated Flexible-TENGs demonstrated impressive pressure-sensing capabilities, featuring dual sensitivity of 7.287 V/kPa for low pressure and 0.663 V/kPa for higher pressure. Moreover, the PDMS-encapsulated TENG sensor effectively traced the physiological motions, such as wrist and finger bending, and efficiently harnessed the waste energy from everyday physical activities, such as walking and jogging. The maximum peak-to-peak voltages of 18.3 and 57.4 V were recorded during these motions. Encapsulated TENGs have broad potential in wearable technology, including healthcare, human-machine interfaces, and energizing microelectronics.
柔性可穿戴皮肤三电纳米发电机(TENGs)因其兼容的设计和低频工作能力,已成为自供电触觉和压力传感器以及机械能收集器的理想候选材料。由于三元正极材料的选择有限,大多数研究都集中在为柔性 TENG 改进三元负极材料上。对于可穿戴传感器来说,在保持灵敏度和能量收集能力的同时实现生物兼容性是另一个关键问题。在此,我们报告了一种基于 TENG 的生物相容性和自供电压力传感器,它采用逐层沉积的简单制造方法。层叠柔性 TENG 由聚四氟乙烯(PTFE)和聚甲基丙烯酸甲酯(PMMA)薄膜组成,嵌入柔性生物相容性聚二甲基硅氧烷(PDMS)基质中。通过氧等离子体获得的纳米结构 PDMS 表面有助于溅射沉积分层的氧化铟锡铜电极和顶部的三正极 PMMA 薄层。在铜上添加氧化铟锡层可显著提高氧化铟锡铜电极的质量和性能。自供电层叠柔性 TENG 展示了令人印象深刻的压力感应能力,具有双重灵敏度,低压灵敏度为 7.287 V/kPa,高压灵敏度为 0.663 V/kPa。此外,PDMS 封装的 TENG 传感器还能有效追踪手腕和手指弯曲等生理运动,并有效利用步行和慢跑等日常体力活动产生的废能。在这些运动中记录到的最大峰峰电压分别为 18.3 和 57.4 V。封装的 TENG 在可穿戴技术领域具有广泛的应用潜力,包括医疗保健、人机界面和增能微电子。
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引用次数: 0
From natural leather to intelligent wearable nanocomposite: design and application 从天然皮革到智能可穿戴纳米复合材料:设计与应用
Pub Date : 2024-01-18 DOI: 10.20517/ss.2023.47
Ziyang Fan, Min Sang, Xinglong Gong, Ken Cham-Fai Leung, Shouhu Xuan
As a natural material, leather has been widely used in daily life due to its high biocompatibility, wearing comfort, and excellent mechanical strength. However, with the increasing demand for a better life among people, the single function of leather has difficulty in meeting the requirements, which limits its application prospects. It is particularly important to develop multifunctional leather composites with diverse characteristics. Therefore, leather can be modified and functionally designed through physical and chemical methods towards intelligent wearable devices. From this perspective, we review the research progress of intelligent leather-based wearable composites, mainly focusing on the preparation methods and application directions in recent years. Finally, we emphasize the challenges that leather composites will face in practical applications and propose future research directions.
皮革作为一种天然材料,以其高度的生物相容性、穿着舒适性和优异的机械强度,被广泛应用于日常生活中。然而,随着人们对美好生活需求的不断提高,皮革的单一功能已难以满足要求,限制了其应用前景。开发具有多种特性的多功能皮革复合材料显得尤为重要。因此,可以通过物理和化学方法对皮革进行改性和功能设计,以实现智能可穿戴设备。从这个角度出发,我们回顾了智能皮革基可穿戴复合材料的研究进展,主要集中在近年来的制备方法和应用方向上。最后,我们强调了皮革复合材料在实际应用中将面临的挑战,并提出了未来的研究方向。
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引用次数: 0
Liquid metals enabled advanced cryobiology: development and perspectives 液态金属支持先进低温生物学:发展与前景
Pub Date : 2024-01-17 DOI: 10.20517/ss.2023.43
Fan Yang, Chennan Lu, Wei Rao
Cryosurgery and cryopreservation, as two important categories in cryobiology, have been impeded by the poor thermal conductivity of biological tissues or specimens. To improve this, diverse adjuvants, e.g., carbon-based materials, metallic nanoparticles, metallic oxide nanoparticles, etc ., have been exploited to improve the heat transfer in heat-targeted regions to increase the tumor elimination efficiency as well as the post-thaw viability of cryopreserved specimens. Nevertheless, these materials suffer poor thermal conductivities, controversial biosafety problems, and high expense. Gallium and its alloys, as a class of room-temperature liquid metals (LMs), have been widely studied in the past decade for their low melting point, minor toxicity, outstanding transformability, and conductivity. Integrated with these superior properties, they have been widely applied in multiple fields, such as thermal management, flexible electronics, and soft robotics. Recently, our laboratory has been devoted to fusing LMs with cryobiology and has made a series of progress. In this article, we will first briefly introduce preparation pathways to LM-based functional nanomaterials and composites. Then, how these materials realize improvement in biological heat transfer will be presented, followed by a discussion about the biosafety of these materials, which is an essential concern for the cryobiological field. Recent studies employing LMs in advanced cryosurgery and cryopreservation will also be highlighted. The present challenges and prospects of LMs towards further development in cryobiology will be put forward to point out the possible research direction.
低温手术和低温保存是低温生物学的两个重要类别,但由于生物组织或标本的导热性能较差,这一直阻碍着低温手术和低温保存的进行。为了改善这一问题,人们利用碳基材料、金属纳米颗粒、金属氧化物纳米颗粒等各种辅助剂来改善热目标区域的热传导,从而提高肿瘤消除效率以及低温保存标本解冻后的存活率。然而,这些材料导热性差,生物安全问题备受争议,而且价格昂贵。镓及其合金作为一类室温液态金属(LMs),在过去十年中因其熔点低、毒性小、可转化性和导电性突出而被广泛研究。结合这些优越性能,它们已被广泛应用于热管理、柔性电子和软机器人等多个领域。最近,我们实验室致力于将 LMs 与低温生物学相融合,并取得了一系列进展。在本文中,我们将首先简要介绍基于 LM 的功能纳米材料和复合材料的制备途径。然后,将介绍这些材料如何实现生物传热的改善,最后讨论这些材料的生物安全性,这也是低温生物学领域的一个重要关注点。此外,还将重点介绍在先进冷冻手术和冷冻保存中使用 LMs 的最新研究。LMs 在低温生物学领域的进一步发展所面临的挑战和前景将被提出,并指出可能的研究方向。
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引用次数: 0
A dual-mode wearable sensor with coupled ion and pressure sensing 具有离子和压力耦合传感功能的双模式可穿戴传感器
Pub Date : 2024-01-16 DOI: 10.20517/ss.2023.41
Biao Ma, Ke Huang, Gangsheng Chen, Yingnan Tian, Nan Jiang, Chao Zhao, Hong Liu
Simultaneous monitoring of the body’s biochemical and biophysical signals via wearable devices can provide a comprehensive assessment of an individual’s health state. However, current multifunctional sensors for synchronous biochemical and biophysical sensing rely on discrete sensing units, posing a limitation in increased complexity in device assembly, signal processing, and system integration. In this study, we report a dual-mode and self-powered wearable sensor with ion and pressure-sensing capabilities by interfacing a hydrogel film with a solid ion-selective electrode. The hydrogel film can not only collect natural sweat from the skin but also offer a piezoionic response to pressure. We show that wrist pulse-induced pressure response can be incorporated into the noise of the response to sweat sodium ions, allowing for the simultaneous measurement of heart rate and sweat electrolytes. This work provides an example of simplifying the development of wearable multimode sensors through the rational design of classic electrochemical sensors.
通过可穿戴设备对人体的生化和生物物理信号进行同步监测,可以全面评估个人的健康状况。然而,目前用于同步生化和生物物理传感的多功能传感器依赖于离散的传感单元,这就限制了设备组装、信号处理和系统集成的复杂性。在本研究中,我们报告了一种具有离子和压力传感功能的双模自供电可穿戴传感器,它将水凝胶薄膜与固体离子选择电极连接在一起。水凝胶薄膜不仅能收集皮肤上的天然汗液,还能对压力产生压电响应。我们的研究表明,腕部脉搏引起的压力响应可以被纳入汗液钠离子响应的噪声中,从而可以同时测量心率和汗液电解质。这项研究为通过合理设计经典电化学传感器来简化可穿戴多模传感器的开发提供了一个范例。
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引用次数: 0
Printing surface cuprous oxides featured liquid metal for non-enzymatic electrochemical glucose sensor 以液态金属为特征的印刷表面氧化亚铜用于非酶电化学葡萄糖传感器
Pub Date : 2024-01-15 DOI: 10.20517/ss.2023.40
Yiyao Luo, Gengcheng Liao, Zixuan Guo, Zongyu Huang, L. Ren, Xiang Qi
Electrochemical glucose sensors that rely on two-dimensional (2D) oxides have attracted significant attention owing to the strong sensing activity of 2D oxides, but their practical application is hindered by the complexity and high cost of fabrication of electrodes and integrated devices. Herein, a convenient and effective fabrication route that includes printing a Ga-based liquid metal (LM) as a current collection electrode, followed by growing electrochemically active 2D oxides directly on the surface of Ga-based LMs under mild conditions, is developed for non-enzyme-based electrochemical sensors. Specifically, 2D annealed Cu-Oxide (ACO) is successfully grown on a printed Ga electrode through a galvanic replacement reaction, resulting in the formation of a mechanically and electrically well-matched interface between the active sensing materials and the current collection substrate. Benefitting from the high quantity of 2D ACO and good charge transfer at the interface, the as-prepared ACO electrode exhibits attractive glucose sensing performance, with a wide linear range (1 μM-10 mM) of effective detection, low detection limit down to 1 μM, and high sensitivity of 0.87 μA·mM-1·cm-2. Our study highlights the potential of using LMs in bio-sensing applications and provides a non-enzyme-based electrochemical biosensor platform for effective glucose detection in diets and clinical diagnostic settings.
由于二维(2D)氧化物具有很强的传感活性,因此依赖于二维(2D)氧化物的电化学葡萄糖传感器备受关注,但其实际应用却因电极和集成器件制造的复杂性和高成本而受到阻碍。本文为非酶电化学传感器开发了一种便捷有效的制备路线,包括打印镓基液态金属(LM)作为集流电极,然后在温和条件下直接在镓基液态金属表面生长电化学活性二维氧化物。具体来说,二维退火氧化铜(ACO)通过电化学置换反应成功地生长在印刷镓电极上,从而在活性传感材料和电流收集基底之间形成了机械和电气匹配良好的界面。得益于大量的二维 ACO 和界面上良好的电荷转移,制备的 ACO 电极表现出极具吸引力的葡萄糖传感性能,有效检测线性范围宽(1 μM-10 mM),检测限低至 1 μM,灵敏度高达 0.87 μA-mM-1-cm-2。我们的研究凸显了将 LMs 用于生物传感应用的潜力,并为在饮食和临床诊断环境中有效检测葡萄糖提供了一种非酶基电化学生物传感器平台。
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引用次数: 0
A review: flexible devices for nerve stimulation 综述:用于神经刺激的柔性设备
Pub Date : 2024-01-10 DOI: 10.20517/ss.2023.36
Ze-Qing Liu, Xiang-Yang Yu, Jing Huang, Xin-Yi Wu, Zi-Yu Wang, Ben-Peng Zhu
Nerve stimulation technology utilizing electricity, magnetism, light, and ultrasound has found extensive applications in biotechnology and medical fields. Neurostimulation devices serve as the crucial interface between biological tissue and the external environment, posing a bottleneck in the advancement of neurostimulation technology. Ensuring safety and stability is essential for their future applications. Traditional rigid devices often elicit significant immune responses due to the mechanical mismatch between their materials and biological tissues. Consequently, there is a growing demand for flexible nerve stimulation devices that offer enhanced treatment efficacy while minimizing irritation to the human body. This review provides a comprehensive summary of the historical development and recent advancements in flexible devices utilizing four neurostimulation techniques: electrical stimulation, magnetic stimulation, optic stimulation, and ultrasonic stimulation. It highlights their potential for high biocompatibility, low power consumption, wireless operation, and superior stability. The aim is to offer valuable insights and guidance for the future development and application of flexible neurostimulation devices.
利用电、磁、光和超声波的神经刺激技术已广泛应用于生物技术和医疗领域。神经刺激设备是生物组织与外部环境之间的重要接口,是神经刺激技术发展的瓶颈。确保安全性和稳定性对其未来的应用至关重要。传统的刚性装置由于其材料与生物组织之间的机械不匹配,往往会引起严重的免疫反应。因此,人们对柔性神经刺激设备的需求日益增长,这种设备既能提高治疗效果,又能最大限度地减少对人体的刺激。本综述全面总结了采用四种神经刺激技术(电刺激、磁刺激、光学刺激和超声波刺激)的柔性设备的历史发展和最新进展。它强调了这些设备在高生物相容性、低功耗、无线操作和卓越稳定性方面的潜力。目的是为柔性神经刺激设备的未来开发和应用提供有价值的见解和指导。
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引用次数: 0
A facile in-situ reaction method for preparing flexible Sb2Te3 thermoelectric thin films 制备柔性 Sb2Te3 热电薄膜的简便原位反应方法
Pub Date : 2024-01-09 DOI: 10.20517/ss.2023.34
Dongwei Ao, Bo Wu, Jabar Bushra, Bing Sun, Dong Yang, Yiming Zhong, Zhuanghao Zheng
Inorganic p-type Sb2Te3 flexible thin films (f-TFs) with eco-friendly and high thermoelectric performance have attracted wide research interest and potential for commercial applications. This study employs a facile in-situ reaction method to prepare flexible Sb2Te3 thin films by rationally adjusting the synthesized temperature. The prepared thin films show good crystallinity, which enhances the electrical conductivity of ~1,440 S·cm-1 due to the weakened carrier scattering. Simultaneously, the optimized carrier concentration, through adjusting the synthesis temperature, causes the intermediate Seebeck coefficient. Consequently, a high-power factor (16.0 μW·cm-1·K-2 at 300 K) is achieved for Sb2Te3 f-TFs prepared at 623 K. Besides, the f-TFs also exhibit good flexibility due to the slight change in resistance after bending. This study specifies that the in-situ reaction method is an effective route to prepare Sb2Te3 f-TFs with high thermoelectric performance.
具有环保和高热电性能的无机 p 型 Sb2Te3 柔性薄膜(f-TFs)引起了广泛的研究兴趣,并具有商业应用的潜力。本研究采用简便的原位反应方法,通过合理调节合成温度制备柔性 Sb2Te3 薄膜。所制备的薄膜具有良好的结晶性,由于载流子散射减弱,导电性能提高到 ~1,440 S-cm-1。同时,通过调节合成温度,优化了载流子浓度,从而获得了中间塞贝克系数。因此,在 623 K 下制备的 Sb2Te3 f-TFs 实现了较高的功率因数(300 K 时为 16.0 μW-cm-1-K-2)。这项研究表明,原位反应法是制备具有高热电性能的 Sb2Te3 f-TFs 的有效途径。
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引用次数: 0
Tuning Ag+ and Mn2+ doping in ZnS:Ag,Mn embedded polymers for flexible white light emitting films 调节 ZnS:Ag、Mn 嵌入聚合物中的 Ag+ 和 Mn2+ 掺杂,制造柔性白光发光薄膜
Pub Date : 2024-01-04 DOI: 10.20517/ss.2023.32
Lun Ma, E. Amador, George S. Belev, Chhabindra Gautam, Weidong Zhou, J. P. Liu, R. Sammynaiken, Wei Chen
Flexible Light Emitting Diodes are versatile lighting solutions that offer bendable and adaptable illumination possibilities. A soft, flexible white luminescent film (1 mm) shows promise for foldable electroluminescent devices and applications. This film was fabricated using ZnS:Ag and Mn. Under different excitation wavelengths, the phosphors emit blue light due to Ag+ luminescence centers and red light from the d-d transition of Mn2+. The blue emission is greatly suppressed at high Mn2+ doping levels, requiring reduced Ag+ doping in co-doped ZnS:Ag,Mn compared to solo-doped ZnS:Ag samples. By adjusting Ag+ and Mn2+ concentrations, the ZnS:Ag(1%),Mn(0.2%) phosphors show a proper intensity ratio of blue and red emissions, making them a promising candidate for future white light applications.
柔性发光二极管是一种多功能照明解决方案,可提供可弯曲和适应性强的照明可能性。一种柔软、灵活的白色发光薄膜(1 毫米)显示了可折叠电致发光器件和应用的前景。这种薄膜是用 ZnS:Ag 和 Mn 制成的。在不同的激发波长下,荧光粉因 Ag+ 发光中心而发出蓝光,因 Mn2+ 的 d-d 转变而发出红光。与单独掺杂的 ZnS:Ag 样品相比,在高 Mn2+掺杂水平下,蓝色发射被大大抑制,这就要求减少共掺杂 ZnS:Ag,Mn 中的 Ag+掺杂。通过调整 Ag+ 和 Mn2+ 的浓度,ZnS:Ag(1%),Mn(0.2%) 荧光粉显示出适当的蓝光和红光发射强度比,使其成为未来白光应用的理想候选材料。
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引用次数: 0
Flourishing electronic textiles towards pervasive, personalized and intelligent healthcare 发展电子纺织品,实现无处不在的个性化和智能化医疗保健
Pub Date : 2024-01-04 DOI: 10.20517/ss.2023.35
Feifan Sheng, Cheng Zhao, Bo Zhang, Yingxue Tan, Kai Dong
In the face of pandemic infectious diseases and increasing aging trends, traditional public health systems lack the capacity for real-time monitoring, immediate clinical detection, continuous vital sign monitoring, and the implementation of long-cycle treatment protocols, among other deficiencies. On the basis of the rapid development of wearable electronic devices, the Internet of Things, and artificial intelligence, the future healthcare model will transform from a therapeutic, centralized, passive, and even one-size-fits-all treatment to a new paradigm of proactive, preventive, personalized, customized, and intelligent way. The development of wearable electronics has facilitated the evolution of healthcare from healthcare to biological monitoring, enabling continuous monitoring of critical biomarkers for diagnostic treatment, physiological health monitoring, and assessment. Electronic textiles (e-textiles) are among the rapidly developing wearable electronics in recent years. They have revolutionized the functionality of traditional textiles by incorporating smart attributes, enabling unique and multifunctional applications. Significantly, e-textiles have made notable advancements in the field of personalized healthcare. The article introduces several common e-textiles and their applications in personalized medicines, which also gives a forward-looking outlook on their future growth in infectious diseases, real-time health preventive monitoring, auxiliary therapy, and rehabilitation training.
面对流行性传染病和日益加剧的老龄化趋势,传统的公共卫生系统缺乏实时监测、即时临床检测、连续生命体征监测和实施长周期治疗方案等能力。在可穿戴电子设备、物联网和人工智能快速发展的基础上,未来的医疗模式将从治疗型、集中型、被动型,甚至一刀切的治疗方式转变为主动型、预防型、个性化、定制化、智能化的新模式。可穿戴电子设备的发展促进了医疗保健从医疗保健向生物监测的演变,实现了对诊断治疗、生理健康监测和评估所需的关键生物标志物的连续监测。电子纺织品是近年来发展迅速的可穿戴电子产品之一。它们通过融入智能属性,实现了独特的多功能应用,从而彻底改变了传统纺织品的功能。值得一提的是,电子纺织品在个性化医疗保健领域取得了显著进展。本文介绍了几种常见的电子纺织品及其在个性化医疗中的应用,并对其在传染病、实时健康预防监测、辅助治疗和康复训练等方面的未来发展进行了前瞻性展望。
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引用次数: 0
Emerging epidermal electrodes towards digital health and on-skin digitalization 面向数字健康和皮肤数字化的新兴表皮电极
Pub Date : 2024-01-01 DOI: 10.20517/ss.2023.44
Yan Wang
Epidermal electrodes can be directly attached to the human skin for high-fidelity electrophysiological monitoring owing to their preponderance in thinness, lightweight, conformability, biocompatibility, self-adhesiveness, mechanical flexibility, gas-permeability, etc. These devices have attracted immense attention due to their emerging applications in personalized health care, human/brain-machine interfaces, and soft robotics. This Perspective focuses on the most recent significant progress in this area, especially materials, properties, and applications. Challenges and prospects are summarized to underscore the unexploited areas and future directions toward digital health and on-skin digitalization.
由于表皮电极具有轻薄、顺应性、生物相容性、自粘性、机械柔韧性、气体渗透性等优点,可直接附着在人体皮肤上进行高保真电生理监测。这些设备在个性化医疗保健、人/脑-机接口和软机器人等领域的新兴应用引起了广泛关注。本视角聚焦于该领域的最新重大进展,尤其是材料、特性和应用。此外,还总结了面临的挑战和发展前景,强调了尚未开发的领域以及数字健康和皮肤数字化的未来方向。
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引用次数: 0
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Soft science
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