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Liquid metal neuro-electrical interface 液态金属神经-电气接口
Pub Date : 2024-06-11 DOI: 10.20517/ss.2023.58
Xilong Zhang, Chang Liu, Rongyu Tang, Weichen Feng, Jingru Gao, Bingjie Wu, Zhongshan Deng, Jing Liu, Lei Li
Liquid metal (LM), an emerging functional material, plays increasing roles in biomedical and healthcare areas. It has particular values in neural interfaces as it combines high conductivity, flowability, and biocompatibility properties. Neuro-electrical interfaces (NEIs) are effective tools to provide a bridge between the nervous system and the outside world. The main target of developing neural interfaces is to help disabled people repair damaged nerves and enhance human capacity above normal ability. This article systematically summarizes LM-based neural interface technologies, including neural electrodes for electrical signal acquisition and administration of electrical stimulation and nerve guidance conduits for neural connectivity and functional reconstruction. The discussion begins with an overview of the fundamental properties associated with LM materials involved in the field of neural interface applications. The fabrication methods of LM-based neuro-electrodes and conduits are then introduced, and the current development status of LM-based neuro-electrodes and conduits is elaborated. Finally, the prospects and possible challenges of LM-based neural interfaces are outlined.
液态金属(LM)是一种新兴的功能材料,在生物医学和医疗保健领域发挥着越来越重要的作用。由于液态金属兼具高导电性、流动性和生物相容性,因此在神经接口方面具有特殊价值。神经电气接口(NEIs)是连接神经系统和外界的有效工具。开发神经接口的主要目标是帮助残疾人修复受损的神经,提高人体能力,使其超过正常人的能力。本文系统地总结了基于 LM 的神经接口技术,包括用于采集电信号和实施电刺激的神经电极,以及用于神经连接和功能重建的神经引导导管。讨论首先概述了神经接口应用领域所涉及的 LM 材料的基本特性。然后介绍了基于 LM 的神经电极和导管的制造方法,并阐述了基于 LM 的神经电极和导管的发展现状。最后,概述了基于 LM 的神经接口的前景和可能面临的挑战。
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引用次数: 0
3D-printed magnetic-based air pressure sensor for continuous respiration monitoring and breathing rehabilitation 用于连续呼吸监测和呼吸康复的 3D 打印磁性气压传感器
Pub Date : 2024-05-24 DOI: 10.20517/ss.2024.11
Nora Asyikin Binti Zulkifli, Wooseong Jeong, Mijin Kim, Cheolgi Kim, Young Hwii Ko, Dong Choon Hyun, Sungwon Lee
The rapid development of point-of-care testing has made prompt diagnosis, monitoring and treatment possible for many patients suffering from chronic respiratory diseases. Currently, the biggest challenge is further optimizing testing devices to facilitate more functionalities with higher efficiency and performance, along with specificity toward patient needs. By understanding that patients with chronic respiratory diseases may have difficulty breathing within a normal range, a respiration sensor is developed focusing on sensitivities in the lower air pressure range. In contrast to the simpler airflow data, the sensor can provide respiratory air pressure as an output using a magnetic-based pressure sensor. This unconventional but highly reliable approach, combined with the rest of the simple 3D-printed design of the sensor, offers a wide range of tunability and functionalities. Due to the detachable components of the respiration sensor, the device can be easily transformed into other respiratory uses such as an inspiratory muscle training device or modified to cater for higher-ranged deep breathing. Therefore, not only does it reach very low air pressure measurement (0.1 cmH2O) for normal, tidal breathing, but the sensor can also be manipulated to detect high levels of air pressure (up to 35 cmH2O for exhalation and 45 cmH2O for inhalation). With its excellent sensitivities (0.0456 mV/cmH2O for inhalation, -0.0940 mV/cmH2O for exhalation), impressive distinction between inhalation and exhalation, and fully reproducible and convenient design, we believe that this respiration sensor will pave the way for developing multimodal and multifunctional respiration sensors within the biomedical field.
护理点检测的快速发展使许多慢性呼吸系统疾病患者能够得到及时诊断、监测和治疗。目前,最大的挑战是进一步优化检测设备,使其具有更多的功能、更高的效率和性能,以及针对患者需求的特异性。由于了解到慢性呼吸系统疾病患者可能在正常范围内呼吸困难,因此开发了一种呼吸传感器,其灵敏度主要集中在较低的气压范围内。与较为简单的气流数据不同,该传感器可通过磁性压力传感器提供呼吸气压输出。这种非常规但高度可靠的方法与传感器其他简单的 3D 打印设计相结合,提供了广泛的可调性和功能。由于呼吸传感器的组件可拆卸,该设备可以很容易地转变为其他呼吸用途,如吸气肌肉训练设备或改装为更大范围的深呼吸设备。因此,它不仅能测量正常潮式呼吸的极低气压(0.1 cmH2O),还能检测高气压(呼气时高达 35 cmH2O,吸气时高达 45 cmH2O)。凭借其出色的灵敏度(吸气为 0.0456 mV/cmH2O,呼气为 -0.0940 mV/cmH2O)、令人印象深刻的吸气和呼气区分以及完全可重复和方便的设计,我们相信这种呼吸传感器将为生物医学领域开发多模态和多功能呼吸传感器铺平道路。
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引用次数: 0
Recent advances of sweat sampling, sensing, energy-harvesting and data-display toward flexible sweat electronics 汗液采样、传感、能量收集和数据显示技术在柔性汗液电子学方面的最新进展
Pub Date : 2024-05-20 DOI: 10.20517/ss.2024.04
Guangyao Zhao, Zhiyuan Li, Xingcan Huang, Qiang Zhang, Yiming Liu, Xinge Yu
Sweat contains diverse types of biomarkers that can mirror an individual’s health condition. The forefront research of sweat monitoring primarily focuses on sensing basic parameters, i.e., sweat rate and single electrolyte imbalances in controlled laboratory settings. However, recent works show the potential of sweat for the rich biomarkers in aspects of comprehensive health status display, timely safety alarming, and energy harvesting. The advances in wearable flexible electronics enable continuous, real-time, noninvasive detection of multiple sweat components, providing molecular-level insights into human physiology and psychology information; additionally, the efficient sweat extraction technologies of flexible electronics promote its application in energy harvesting, contributing to advancing a flexible sweat platform. This review comprehensively explores flexible sweat-based electronics, encompassing four key aspects: sweat sampling methods, sweat-based sensors, sweat-based energy harvesters, and sweat data display methods. Firstly, the traditional sweat-based platform is discussed in sweat sampling, sensing, and data analysis. Then, the development of wearable sweat sampling methods is discussed with a comparison of the traditional sweat collection methods. After that, the recent advances in sweat-based biosensors for monitoring diverse sweat analytes, such as the perspiration volume, glucose, lactate, and uric acid levels, are summarized. Subsequently, this review also highlights the recent progress and potential value of sweat-based energy harvesters in sweat-activated batteries and bio-fuel cells. Furthermore, multiple data display methods are proposed to achieve accurate feedback on health status, such as colorimetric techniques, light-emitting diodes, actuators, etc. Finally, this review concludes the main current challenges faced in practical applications of sweat-based bioelectronic systems and proposes a vision for the future evolution of this promising field.
汗液中含有多种生物标志物,可以反映个人的健康状况。汗液监测的前沿研究主要集中在传感基本参数,即在受控实验室环境下的出汗率和单一电解质失衡。然而,最近的研究表明,汗液在全面显示健康状况、及时发出安全警报和能量收集等方面具有丰富的生物标志物潜力。可穿戴柔性电子设备的进步实现了对多种汗液成分的连续、实时、无创检测,提供了分子层面的人体生理和心理信息;此外,柔性电子设备的高效汗液提取技术促进了其在能量收集方面的应用,有助于推动柔性汗液平台的发展。本综述从汗液采样方法、汗液传感器、汗液能量采集器和汗液数据显示方法四个方面全面探讨了基于汗液的柔性电子技术。首先,从汗液采样、传感和数据分析方面讨论了传统的汗液平台。然后,对比传统的汗液采集方法,讨论了可穿戴汗液采样方法的发展。之后,总结了用于监测各种汗液分析物(如汗液量、葡萄糖、乳酸和尿酸水平)的汗液生物传感器的最新进展。随后,本综述还重点介绍了汗液能量收集器在汗液激活电池和生物燃料电池方面的最新进展和潜在价值。此外,还提出了多种数据显示方法,如比色技术、发光二极管、致动器等,以实现对健康状况的准确反馈。最后,本综述总结了当前汗液生物电子系统在实际应用中所面临的主要挑战,并对这一前景广阔的领域的未来发展提出了展望。
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引用次数: 0
Shape-deformable Micro-LEDs for advanced displays and healthcare 用于先进显示器和医疗保健的可变形 Micro-LED
Pub Date : 2024-05-17 DOI: 10.20517/ss.2024.13
Shenghan Zou, Yuzhi Li, Zheng Gong
Recently, flexible/stretchable micro-scale light-emitting diodes (LEDs), with dimensions significantly smaller than conventional diodes used for illuminations, have emerged for promising applications in areas such as deformable displays, wearable devices for healthcare, etc . For such applications, these devices must have some unusual features that common inorganic LEDs do not intrinsically own, including conformability, biocompatibility, mechanical flexibility, etc . This Perspective focuses on summarizing the most recent progress in developing such flexible emitters based on inorganic semiconductors, followed by reviewing their potential applications. Finally, major challenges and future research directions of deformable micro-scale LEDs are presented.
最近,尺寸明显小于传统照明用二极管的柔性/可伸缩微米级发光二极管(LED)在可变形显示器、医疗保健用可穿戴设备等领域出现了广阔的应用前景。为了实现这些应用,这些设备必须具备普通无机 LED 本身不具备的一些特殊功能,包括保形性、生物相容性、机械灵活性等。本视角重点总结了在开发基于无机半导体的柔性发光体方面取得的最新进展,然后回顾了它们的潜在应用。最后,介绍了可变形微尺度发光二极管面临的主要挑战和未来的研究方向。
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引用次数: 0
Latest developments and trends in electronic skin devices 电子皮肤设备的最新发展和趋势
Pub Date : 2024-05-14 DOI: 10.20517/ss.2024.05
Pengyu Zhu, Zihan Li, Jinbo Pang, Peng He, Shuye Zhang
The skin, a vital medium for human-environment communication, stands as an indispensable and pivotal element in the realms of both production and daily life. As the landscape of science and technology undergoes gradual evolution and the demand for seamless human-machine interfaces continues to surge, an escalating need emerges for a counterpart to our biological skin - electronic skins (e-skins). Achieving high-performance sensing capabilities comparable to our skin has consistently posed a formidable challenge. In this article, we systematically outline fundamental strategies enabling e-skins with capabilities including strain sensing, pressure sensing, shear sensing, temperature sensing, humidity sensing, and self-healing. Subsequently, complex e-skin systems and current major applications were briefly introduced. We conclude by envisioning the future trajectory, anticipating continued advancements and transformative innovations shaping the dynamic landscape of e-skin technology. This article provides a profound insight into the current state of e-skins, potentially inspiring scholars to explore new possibilities.
皮肤是人类与环境交流的重要媒介,是生产和日常生活中不可或缺的关键元素。随着科学技术的逐步发展和对无缝人机界面需求的不断增长,人们对与生物皮肤相对应的电子皮肤(e-skin)的需求日益增长。实现与皮肤相媲美的高性能传感能力一直是一项艰巨的挑战。在本文中,我们系统地概述了使电子皮肤具备应变传感、压力传感、剪切传感、温度传感、湿度传感和自愈等功能的基本策略。随后,我们简要介绍了复杂的电子皮肤系统和当前的主要应用。最后,我们展望了未来的发展轨迹,预计电子皮肤技术的持续进步和变革性创新将塑造电子皮肤技术的动态景观。这篇文章深刻揭示了电子皮肤的现状,可能会激发学者们探索新的可能性。
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引用次数: 0
Controlling the lifetime of biodegradable electronics: from dissolution kinetics to trigger acceleration 控制可生物降解电子器件的使用寿命:从溶解动力学到触发加速度
Pub Date : 2024-04-23 DOI: 10.20517/ss.2024.06
You-Jung Park, Young‐In Ryu, Myung-Kyun Choi, Kyung-Sub Kim, Seung-Kyun Kang
Biodegradable electronics have revolutionized the field of medical devices by offering inherent advantages such as natural disintegration after a useful functional period, thereby eliminating the need for removal surgery. This paradigm shift addresses challenges with long-term implantation, the risks of secondary surgeries, and potential complications, offering a safer and more patient-friendly approach to temporary implantable devices. This review delves into the dissolution kinetics of materials and strategies for lifetime control providing a comprehensive overview of recent advancements in biodegradable electronics. Understanding the kinetics is crucial for meeting the required functional lifetime for implantable medical applications, which varies based on application scope and target diseases. The dissolution kinetics of silicon and biodegradable metals form the core of the discussion, focusing on recent studies aimed at controlling the dissolution rate and enhancing properties. The exploration extends to ideas for accelerating material degradation or initiating on-demand degradation in biodegradable electronics after stable function. Additionally, the compilation of encapsulation layer materials and strategies enhances understanding of how to improve the stable operation time of devices. Emphasis is placed on efforts to adjust the lifetime of biodegradable electronics, particularly in medical applications.
生物可降解电子器件通过提供固有的优势,如在有用功能期后自然分解,从而无需进行移除手术,在医疗器械领域掀起了一场革命。这种模式的转变解决了长期植入、二次手术风险和潜在并发症等难题,为临时植入式设备提供了一种更安全、更方便患者的方法。本综述深入探讨了材料的溶解动力学和寿命控制策略,全面概述了生物可降解电子器件的最新进展。要达到植入式医疗应用所需的功能寿命,了解其动力学至关重要。硅和生物可降解金属的溶解动力学是讨论的核心,重点是旨在控制溶解速率和提高性能的最新研究。探讨还延伸到加速材料降解或在生物可降解电子器件功能稳定后启动按需降解的想法。此外,通过对封装层材料和策略的汇编,加深了对如何提高器件稳定运行时间的理解。重点是努力调整可生物降解电子器件的使用寿命,特别是在医疗应用方面。
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引用次数: 0
Wearable electrochemical sensors for real-time monitoring in diabetes mellitus and associated complications 用于实时监测糖尿病及相关并发症的可穿戴电化学传感器
Pub Date : 2024-04-23 DOI: 10.20517/ss.2024.02
Han Hee Jung, Hyeokjun Lee, Junwoo Yea, Kyung-In Jang
This comprehensive review underscores the pivotal role wearable electrochemical sensors play in the proactive management and prevention of diabetes mellitus (DM) and its associated complications. Acknowledging the substantial impact of DM on individuals and the urgency for effective monitoring strategies, wearable sensors have emerged as a pragmatic solution. These sensors can detect analytical signals from biofluids, including sweat, tears, saliva, and interstitial fluid (ISF), employing minimally invasive techniques facilitated by technological advancements. The seamless integration of these sensors with computational platforms such as smartphones enhances their practicality for routine use. The review systematically explores diverse methodologies, encompassing both enzymatic and non-enzymatic principles, employed for the surveillance of analytes within biofluids. These foundational principles are meticulously applied to wearable devices, affording point-of-care solutions catering to the detection of individual analytes or simultaneous multiplexed analyte detection. The integration of wireless systems and the incorporation of machine learning algorithms introduce a layer of sophistication, elevating the capability of these sensors for the nuanced monitoring of DM and its complications. Through an in-depth analysis of these advancements, this review describes the significant potential of wearable electrochemical sensors as an essential tool for real-time monitoring and managing DM. The diverse approaches presented underscore the adaptability, versatility, and inherent efficacy of these sensors in addressing the multifaceted challenges intrinsic to DM and its associated complications within academic discourse.
这篇综述强调了可穿戴电化学传感器在主动管理和预防糖尿病(DM)及其相关并发症方面发挥的关键作用。认识到糖尿病对个人的重大影响以及制定有效监测策略的紧迫性,可穿戴传感器已成为一种实用的解决方案。这些传感器可以利用技术进步带来的微创技术,从汗液、泪液、唾液和组织间液(ISF)等生物流体中检测分析信号。这些传感器与智能手机等计算平台的无缝集成提高了其日常使用的实用性。本综述系统地探讨了用于监测生物流体中分析物的各种方法,包括酶和非酶原理。这些基本原理被细致地应用到可穿戴设备中,提供了满足单个分析物检测或同步多重分析物检测的护理点解决方案。无线系统的集成和机器学习算法的加入使这些传感器的功能更加复杂,从而提高了对糖尿病及其并发症进行细致监测的能力。通过对这些进展的深入分析,本综述介绍了可穿戴电化学传感器作为实时监测和管理 DM 的重要工具所具有的巨大潜力。所介绍的各种方法强调了这些传感器在应对 DM 及其相关并发症所固有的多方面挑战方面的适应性、多功能性和固有功效。
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引用次数: 0
Soft alchemy: a comprehensive guide to chemical reactions for pneumatic soft actuation 软炼金术:气动软传动化学反应综合指南
Pub Date : 2024-03-29 DOI: 10.20517/ss.2023.52
Marcos Villeda-Hernandez, Benjamin C. Baker, Christian Romero, Jonathan M. Rossiter, C. Faul
Soft robotics has emerged as a transformative field, leveraging bio-inspired novel actuation mechanisms to enable more adaptable, compliant, and sophisticated robotic systems. However, the portability of soft pneumatic actuators is typically constrained by the tethering to bulky power sources. This review offers a thorough analysis of autonomous power alternatives facilitated by chemical reactions for gas generation and absorption, a concept analogous to biological energy conversion processes. These bio-inspired strategies propel soft pneumatic actuators towards new horizons of autonomy and portability, essential for real-world applications. This comprehensive review explores the critical intersection of gas evolution reactions (GERs) and gas consumption reactions (GCRs) as a power source for pneumatic actuation in soft robotics. We here emphasize the importance and impact of bio-inspired design, control, efficiency, safety, and sustainability within soft robotics to not only mimic biological motions but to enhance them. This review explores the fundamentals of both pneumatic and chemically powered actuation, highlighting the need for careful consideration of reaction kinetics. Additionally, this work highlights key aspects of smart materials that draw from biological structures and response mechanisms, along with state-of-the-art techniques for precise pressure modulation. Finally, we chart prospective development pathways and provide a future outlook for bio-inspired soft robotics, emphasizing the transformative impact of integrating chemical actuation methods. This exploration underlines the quest for further autonomy in soft robotic systems and points towards the future opportunities in this exciting and fast-developing field.
软体机器人技术已成为一个变革性领域,它利用生物启发的新型执行机制,实现了适应性更强、顺应性更高和更复杂的机器人系统。然而,软气动致动器的便携性通常受制于笨重的动力源。本综述深入分析了通过化学反应促进气体生成和吸收的自主动力替代方案,这一概念类似于生物能量转换过程。这些受生物启发的策略将软气动执行器推向自主性和便携性的新境界,这对现实世界的应用至关重要。这篇综述探讨了气体进化反应(GER)和气体消耗反应(GCR)作为软机器人气动致动器动力源的关键交叉点。我们在此强调生物启发设计、控制、效率、安全性和可持续性在软机器人技术中的重要性和影响,不仅要模仿生物运动,还要增强它们。本综述探讨了气动和化学动力驱动的基本原理,强调了仔细考虑反应动力学的必要性。此外,本研究还强调了智能材料的关键方面,这些方面借鉴了生物结构和反应机制,以及精确压力调制的最新技术。最后,我们描绘了生物启发软机器人技术的发展前景,并对未来进行了展望,强调了整合化学驱动方法的变革性影响。这一探索强调了软机器人系统对进一步自主性的追求,并指出了这一令人兴奋和快速发展领域的未来机遇。
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引用次数: 0
A review of worm-like pipe inspection robots: research, trends and challenges 蠕虫式管道检测机器人综述:研究、趋势和挑战
Pub Date : 2024-03-25 DOI: 10.20517/ss.2023.49
Gabrielle Blewitt, D. Cheneler, Jeremy Andrew, Stephen Monk
In recent years, the development of worm-like robots has increased significantly. These robots use peristaltic motion comprised of radial expansion and axial elongation to move leglessly through their environments. Soft worm-like robots have the advantage of conforming to their environment, making them ideal for confined spaces such as pipelines which are essential to societal infrastructure. Pipeline contamination and corrosion can be detrimental and costly and thus regular checking is vital. Some pipes are difficult to access due to size, access restrictions and harmful waste contamination (such as in nuclear power plants). This has led to an increase of research into soft worm-like robots for pipe inspection. This review will analyse the recent progress in this area to assess current robotic capabilities and where work may be further needed to ensure they are applicable to real-world applications.
近年来,蠕虫机器人的发展速度明显加快。这些机器人利用由径向伸缩和轴向伸长组成的蠕动运动,在环境中无腿移动。软蠕虫机器人具有适应环境的优势,因此非常适合在密闭空间中使用,例如对社会基础设施至关重要的管道。管道污染和腐蚀会造成危害和损失,因此定期检查至关重要。由于管道尺寸、进出限制和有害废物污染(如核电站)等原因,有些管道很难进入。因此,用于管道检测的软蠕虫机器人的研究越来越多。本综述将分析该领域的最新进展,以评估当前的机器人能力,以及在哪些方面可能需要进一步努力,以确保它们适用于现实世界的应用。
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引用次数: 0
Coupled mechanics in skin-interfaced electronics via computer vision methods 通过计算机视觉方法实现皮肤表面电子器件中的耦合力学
Pub Date : 2024-02-21 DOI: 10.20517/ss.2023.50
Jin-Tae Kim, L. Chamorro
Recent advancements in materials and mechanics have paved the way for transforming rigid circuits into flexible electronics. Their ability to laminate onto the skin has led to the development of skin-interfaced electronics, including mechano-acoustic sensors and haptic systems. However, the challenges of the coupled mechanics between the skin and skin-interfaced electronics call for further understanding of biomechanics, bioelectronics, and their interactions. This perspective article highlights the emerging trend of employing computer vision methods to optimize the next generation of skin-interfaced electronics by characterizing associated biomechanics and vice versa. The cyclic research process involves the development of soft electronics, the identification of coupled mechanics, and their quantification using computer vision methods. The article describes state-of-the-art computer vision techniques in the context of skin-interfaced electronics and their potential applications in other forms of soft electronics.
材料和机械方面的最新进展为将刚性电路转化为柔性电子器件铺平了道路。由于它们能够贴合皮肤,因此开发出了皮肤表面电子器件,包括机械声传感器和触觉系统。然而,皮肤与皮肤表面电子器件之间的耦合力学所带来的挑战,要求我们进一步了解生物力学、生物电子学及其相互作用。这篇视角文章强调了一种新兴趋势,即通过表征相关的生物力学来利用计算机视觉方法优化下一代肤面电子设备,反之亦然。循环研究过程包括开发软电子器件、识别耦合力学以及使用计算机视觉方法对其进行量化。文章介绍了最先进的皮肤界面电子学计算机视觉技术及其在其他形式软电子学中的潜在应用。
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引用次数: 0
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Soft science
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