Hirata Ryuichi, Kojima Koji, Teramoto Yuji, Saigusa Noriaki
{"title":"Effect of conditions in the production of highly soluble powder from tomatoes using microbial enzyme preparation","authors":"Hirata Ryuichi, Kojima Koji, Teramoto Yuji, Saigusa Noriaki","doi":"10.5897/ajbr2024.1182","DOIUrl":"https://doi.org/10.5897/ajbr2024.1182","url":null,"abstract":"","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"18 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ndidi Nwachoko, Udiomine B. Akuru, Inyingi A. Green, Reward M. Kpaanadee, T. Odinga, C. O. Egbunefu
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{"title":"Physicochemical properties and fatty acid composition of freshly prepared palm oil","authors":"Ndidi Nwachoko, Udiomine B. Akuru, Inyingi A. Green, Reward M. Kpaanadee, T. Odinga, C. O. Egbunefu","doi":"10.5897/ajbr2023.1167","DOIUrl":"https://doi.org/10.5897/ajbr2023.1167","url":null,"abstract":".","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85718598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nabéde Aklesso, Sina Haziz, Souho Tiatou, Mélila Mamatchi, T. Farid, A. Adolphe, Ouadja Batcha, B. Lamine, Amouzou Kou’santa
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{"title":"Physicochemical parameters of Blighia sapida (K.D. Koenig) oil extracted in Togo","authors":"Nabéde Aklesso, Sina Haziz, Souho Tiatou, Mélila Mamatchi, T. Farid, A. Adolphe, Ouadja Batcha, B. Lamine, Amouzou Kou’santa","doi":"10.5897/ajbr2022.1158","DOIUrl":"https://doi.org/10.5897/ajbr2022.1158","url":null,"abstract":".","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73241303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatoumata Tall, E. H. Ndour, M. Djité, Oumou K. Barry, P. Kandji, P. M. Gueye, A. Cissé, P. L. Sall
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{"title":"Effects of Quantitative Trait Loci (QTLs) of BCL11A and HBS1L-MYB genes on clinical-biological variability of sickle cell disease in a Senegalese pediatric population","authors":"Fatoumata Tall, E. H. Ndour, M. Djité, Oumou K. Barry, P. Kandji, P. M. Gueye, A. Cissé, P. L. Sall","doi":"10.5897/ajbr2022.1154","DOIUrl":"https://doi.org/10.5897/ajbr2022.1154","url":null,"abstract":".","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83032885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ba Abou, Fatou Coly Najah, Basse Idrissa, Hadji Ibrahima Kane El, Awa Ka Penda, Soumboundou Mamadou, Thiam Souleymane, Samba Abdourahmane, Ndiaye Arame, Yaya Soumah Idrissa, Diedhiou Fatou, Cissé Fatou, Djité Moustapha, Oumou Kesso Barry Néné, M. Pape, Madiéye Gueye Papa, Diallo Fatou, Ramatoulaye Diagne Gueye Ndéye
{"title":"Prevalence and associated risk factors of Vitamin D deficiency in children under five years of age, at the Diamniadio Childrens Hospital in Senegal","authors":"Ba Abou, Fatou Coly Najah, Basse Idrissa, Hadji Ibrahima Kane El, Awa Ka Penda, Soumboundou Mamadou, Thiam Souleymane, Samba Abdourahmane, Ndiaye Arame, Yaya Soumah Idrissa, Diedhiou Fatou, Cissé Fatou, Djité Moustapha, Oumou Kesso Barry Néné, M. Pape, Madiéye Gueye Papa, Diallo Fatou, Ramatoulaye Diagne Gueye Ndéye","doi":"10.5897/ajbr2022.1152","DOIUrl":"https://doi.org/10.5897/ajbr2022.1152","url":null,"abstract":"","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80812796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jalin Herbal Mannex Liquid (JHML) is a polyherbal formulation from honey, Panax ginseng, Liriosma ovate, and Lepidium mehenil, intended for enhanced sexual performance and improve sperm count in men. JHML was studied via its effect on body weight, biochemical indices and histopathology of the testes. Twenty healthy Wistar rats of 120 -150 g weight were allotted into groups A and B., of ten rats each, group A (control), were given 2 mL/kg B.W of tap water, group B were dosed with 2 mL/kg B.W of JHML for four weeks with the animals allowed access to feed and water ad-libitum. Blood were obtained through heart perforation, kidney and testes were excised, washed with normal buffered saline. Results from the investigation indicated that JHML had androgenic properties with marked significant increase (p˂0.05) in body weight of rats administered with JHML. Significant increase (p˂0.05) was observed in LH, FSH, testosterone and with a concomitant significant decrease (p˂0.05) in PRL. The JHML caused non-significant decrease (p>0.05) on triglycerides and cholesterol but with positive significant effect (p ˂ 0.05) on LDL and HDL. No significant changes (p>0.05) on creatinine, urea, uric acid and serum electrolytes. Testicular sections of rats treated with JHML exhibited normal features, seminiferous epithelium and interstitial tissues with active spermatogene sis. The significant increase (p˂0.05) in testosterone, LH, FSH with a concomitant significant decrease (p˂0.05) in PRL may account for its sex invigorating potential, the non-significant changes observed in some biochemical indices of the rats showed that JHML is relatively safe at the studied dose.
{"title":"Investigation into the intake of a popular polyherbal drug (Jalin Herbal Mannex Liquid) on selected biochemical indices of male wister rats","authors":"E. D. Kpomah, E. M. Arhoghro","doi":"10.5897/ajbr2022.1150","DOIUrl":"https://doi.org/10.5897/ajbr2022.1150","url":null,"abstract":"Jalin Herbal Mannex Liquid (JHML) is a polyherbal formulation from honey, Panax ginseng, Liriosma ovate, and Lepidium mehenil, intended for enhanced sexual performance and improve sperm count in men. JHML was studied via its effect on body weight, biochemical indices and histopathology of the testes. Twenty healthy Wistar rats of 120 -150 g weight were allotted into groups A and B., of ten rats each, group A (control), were given 2 mL/kg B.W of tap water, group B were dosed with 2 mL/kg B.W of JHML for four weeks with the animals allowed access to feed and water ad-libitum. Blood were obtained through heart perforation, kidney and testes were excised, washed with normal buffered saline. Results from the investigation indicated that JHML had androgenic properties with marked significant increase (p˂0.05) in body weight of rats administered with JHML. Significant increase (p˂0.05) was observed in LH, FSH, testosterone and with a concomitant significant decrease (p˂0.05) in PRL. The JHML caused non-significant decrease (p>0.05) on triglycerides and cholesterol but with positive significant effect (p ˂ 0.05) on LDL and HDL. No significant changes (p>0.05) on creatinine, urea, uric acid and serum electrolytes. Testicular sections of rats treated with JHML exhibited normal features, seminiferous epithelium and interstitial tissues with active spermatogene sis. The significant increase (p˂0.05) in testosterone, LH, FSH with a concomitant significant decrease (p˂0.05) in PRL may account for its sex invigorating potential, the non-significant changes observed in some biochemical indices of the rats showed that JHML is relatively safe at the studied dose.","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73726583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. E. Egoamaka, Ezedom Theresa, A. A. Akpovwehwee, Aganbi Eferhire, Amata Alex-Ifo, J. T. Nyerhovwo
The antioxidant and antigenotoxic effects of solid state fermented cassava ( Manihot esculenta Crantz) using Rhizopus oligosporus were investigated. Solid state fermentation was carried out for 72 h at room temperature under acidic and basic conditions. Total phenolic content was significantly (p<0.05) higher in fermented peeled and unpeeled cassava at pH 7 and 5 when compared with unfermented. Similarly, the total flavonoid contents of fermented peeled and unpeeled cassava at pH 4 and 7 were significantly (p<0.05) higher than in unfermented. Allium cepa assay was used to assess the antigenotoxic effects of unfermented and fermented peeled and unpeeled cassava. The fermented extracts did not induce chromosomal type aberrations in the treated cells. The present study thus showed that R. oligosporus has the ability to breakdown cassava and considerably increase the antioxidant properties in peeled and unpeeled fermented cassava, which may serve as natural antioxidants in industrial broiler chickens.
{"title":"Antioxidants and antigenotoxic properties of Rhizopus oligosporus fermented cassava (Manihot esculenta Crantz)","authors":"O. E. Egoamaka, Ezedom Theresa, A. A. Akpovwehwee, Aganbi Eferhire, Amata Alex-Ifo, J. T. Nyerhovwo","doi":"10.5897/ajbr2022.1153","DOIUrl":"https://doi.org/10.5897/ajbr2022.1153","url":null,"abstract":"The antioxidant and antigenotoxic effects of solid state fermented cassava ( Manihot esculenta Crantz) using Rhizopus oligosporus were investigated. Solid state fermentation was carried out for 72 h at room temperature under acidic and basic conditions. Total phenolic content was significantly (p<0.05) higher in fermented peeled and unpeeled cassava at pH 7 and 5 when compared with unfermented. Similarly, the total flavonoid contents of fermented peeled and unpeeled cassava at pH 4 and 7 were significantly (p<0.05) higher than in unfermented. Allium cepa assay was used to assess the antigenotoxic effects of unfermented and fermented peeled and unpeeled cassava. The fermented extracts did not induce chromosomal type aberrations in the treated cells. The present study thus showed that R. oligosporus has the ability to breakdown cassava and considerably increase the antioxidant properties in peeled and unpeeled fermented cassava, which may serve as natural antioxidants in industrial broiler chickens.","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82019666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dorothy VanderJagt, Lucy Hunsaker, S. Otimenyin, M. O. Uguru
Chronic non-communicable diseases are responsible for a large majority of deaths worldwide. These include cardiovascular and respiratory diseases, diabetes and cancer. Inflammation has been reported to be involved in the initiation or progression of these conditions. Populations in developing or low to middleincome countries often rely on traditional medicine using locally available herbs and plants for their medical care. This study examined the anti-inflammatory potential of aqueous extracts of twelve medicinal plants used in Nigeria. The antioxidant activity was estimated using the total radical-trapping antioxidant parameter (TRAP) and ferric reducing ability (FRAP) assays. The abilities to inhibit nuclear factor kappa light chain enhancer of activated B cells (NfkB), a key regulator of the inflammatory response, and to activate nuclear factorE2 related factor 2 (Nrf2), a transcription factor that regulates cellular antioxidant defense systems, were determined using in vitro cell based assays. Extracts of Erythrina senegalensis (leaves), Sclerocarya birrea (bark), Boswellia dalzielli (leaves and bark), Pseudrocedrila kotschyi (bark), Sterculia setigera (stem bark), and Sarcocephalus esculentus (bark) contained the highest levels of antioxidant activity. Extracts that showed the greatest inhibition of NfkB were S. esculentus (bark), 91.8%; E. senegalensis (leaves), 81.4%; S. birrea (stem bark), 77.5%; and S. setigera (stem bark), 75.5%. B. dalzielli (leaves) and Xylopia aethiopica (leaves) gave 7.4 and 7.7 fold activation of Nrf2, respectively. These were comparable to activation by sulphorophane.
{"title":"The anti-inflammatory activities of twelve Nigerian medicinal plants: Inhibition of NfkB, activation of Nrf2, and antioxidant content","authors":"Dorothy VanderJagt, Lucy Hunsaker, S. Otimenyin, M. O. Uguru","doi":"10.5897/ajbr2021.1134","DOIUrl":"https://doi.org/10.5897/ajbr2021.1134","url":null,"abstract":"Chronic non-communicable diseases are responsible for a large majority of deaths worldwide. These include cardiovascular and respiratory diseases, diabetes and cancer. Inflammation has been reported to be involved in the initiation or progression of these conditions. Populations in developing or low to middleincome countries often rely on traditional medicine using locally available herbs and plants for their medical care. This study examined the anti-inflammatory potential of aqueous extracts of twelve medicinal plants used in Nigeria. The antioxidant activity was estimated using the total radical-trapping antioxidant parameter (TRAP) and ferric reducing ability (FRAP) assays. The abilities to inhibit nuclear factor kappa light chain enhancer of activated B cells (NfkB), a key regulator of the inflammatory response, and to activate nuclear factorE2 related factor 2 (Nrf2), a transcription factor that regulates cellular antioxidant defense systems, were determined using in vitro cell based assays. Extracts of Erythrina senegalensis (leaves), Sclerocarya birrea (bark), Boswellia dalzielli (leaves and bark), Pseudrocedrila kotschyi (bark), Sterculia setigera (stem bark), and Sarcocephalus esculentus (bark) contained the highest levels of antioxidant activity. Extracts that showed the greatest inhibition of NfkB were S. esculentus (bark), 91.8%; E. senegalensis (leaves), 81.4%; S. birrea (stem bark), 77.5%; and S. setigera (stem bark), 75.5%. B. dalzielli (leaves) and Xylopia aethiopica (leaves) gave 7.4 and 7.7 fold activation of Nrf2, respectively. These were comparable to activation by sulphorophane.","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81422041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oumou Kesso Barry Néné, Djité Moustapha, M. Pape, Hadji Malick Ndour El, Assane Ndour Michel, Diédhiou Demba, Fatou Gueye-tall, Palanga Koboyo Alix, Marieme Thioune Ndeye, Fatou Coly Najah, Doupa Dominique, Ndour-Mbaye Maimouna, C. Aynina, Amadou Diop Pape, Lopez-Sall Philomène, Madiéye Gueye Papa
The association between hyperuricemia and metabolic syndrome (MS) has been reported in many studies. The authors performed this cross-sectional study to determine the association between hyperuricemia and the MS among diabetic patients in Dakar. Type 2 diabetic patients received as part of their follow-up at the Marc Sankalé Center of Abass Ndao Hospital in Dakar were enrolled. For each patient, blood samples and 24 h urine collection were performed. Hyperuricemia was defined for uric acid concentrations > 416 µmol/l in men and > 357 µmol/l in women and the MS was evaluated according to WHO criteria. Statistical analysis was done using the XLSTAT 2019 software. A total of 153 type 2 diabetic patients were included with an average age of 56.63 years. Thirty-one percent (31%) of patients had metabolic syndrome and 32% of them had hyperuricemia. Significant correlations were found between serum uric acid and some components of the MS including triglyceride levels (r = 0.25, p = 0.002), microalbuminuria (r = 0.19, p = 0.018), and fasting glucose (r = - 0.22, p = 0.005). The authors found that hyperuricemia is frequent in patients with MS and this could be considered as a biomarker associated with the presence of this syndrome.
高尿酸血症与代谢综合征(MS)之间的关系已在许多研究中报道。作者进行了这项横断面研究，以确定达喀尔糖尿病患者高尿酸血症与多发性硬化症之间的关系。纳入了在达喀尔Abass Ndao医院Marc sankal中心接受随访的2型糖尿病患者。对每位患者进行血样和24 h尿液采集。高尿酸血症的定义为:男性的尿酸浓度为> 416µmol/l，女性的尿酸浓度为> 357µmol/l，并根据WHO标准评估MS。使用XLSTAT 2019软件进行统计分析。2型糖尿病患者153例，平均年龄56.63岁。31%的患者有代谢综合征，32%的患者有高尿酸血症。血清尿酸与MS的一些成分之间存在显著相关性，包括甘油三酯水平(r = 0.25, p = 0.002)、微量白蛋白尿(r = 0.19, p = 0.018)和空腹血糖(r = - 0.22, p = 0.005)。作者发现，高尿酸血症在多发性硬化症患者中很常见，这可以被认为是与该综合征存在相关的生物标志物。
{"title":"Association of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients in Dakar","authors":"Oumou Kesso Barry Néné, Djité Moustapha, M. Pape, Hadji Malick Ndour El, Assane Ndour Michel, Diédhiou Demba, Fatou Gueye-tall, Palanga Koboyo Alix, Marieme Thioune Ndeye, Fatou Coly Najah, Doupa Dominique, Ndour-Mbaye Maimouna, C. Aynina, Amadou Diop Pape, Lopez-Sall Philomène, Madiéye Gueye Papa","doi":"10.5897/ajbr2020.1111","DOIUrl":"https://doi.org/10.5897/ajbr2020.1111","url":null,"abstract":"The association between hyperuricemia and metabolic syndrome (MS) has been reported in many studies. The authors performed this cross-sectional study to determine the association between hyperuricemia and the MS among diabetic patients in Dakar. Type 2 diabetic patients received as part of their follow-up at the Marc Sankalé Center of Abass Ndao Hospital in Dakar were enrolled. For each patient, blood samples and 24 h urine collection were performed. Hyperuricemia was defined for uric acid concentrations > 416 µmol/l in men and > 357 µmol/l in women and the MS was evaluated according to WHO criteria. Statistical analysis was done using the XLSTAT 2019 software. A total of 153 type 2 diabetic patients were included with an average age of 56.63 years. Thirty-one percent (31%) of patients had metabolic syndrome and 32% of them had hyperuricemia. Significant correlations were found between serum uric acid and some components of the MS including triglyceride levels (r = 0.25, p = 0.002), microalbuminuria (r = 0.19, p = 0.018), and fasting glucose (r = - 0.22, p = 0.005). The authors found that hyperuricemia is frequent in patients with MS and this could be considered as a biomarker associated with the presence of this syndrome.","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75524863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Gervais, Jover Bernard, Badia Eric, Djohan Ferdinand, Reynaud Fabrice, Dere, Luc, Niamke Germaine, Chantal Gauze, M. Absalome, Adeoti F Mansour, -. Camara, C. Massara, Cristol Jean Paul
Palm oil has long been incriminated in obesity, and this obesity would be responsible for the development of cardiac fibrosis, several authors have evoked the role of free radicals in the pathophysiological mechanism of the fibrotic response linked to obesity; the aim of this study was therefore to evaluate the profile of NOX2 in the development of cardiac fibrosis in rats subjected to a diet rich in the fat of several vegetable oils, in this case palm oil. A total of forty young male Wistar rats were subjected to several diets (soybean, red and branched palm oil, olive and lard). After twelve weeks of experimentation, the rats were sacrificed after anaesthesia, and the parameters of oxidative stress, inflammation and the level of interstitial fibrosis of the heart were assessed. Our study showed that red palm oil consumption did not lead to overexpression of oxidative stress parameters and inflammatory RNA markers. The expression of myocardial nicotine adenine dinucleotide phosphate oxidase did not change in rats consuming red palm oil compared to the control diet. However, consumption of palm olein, olive and lard resulted in a significant change in myocardial nicotine adenine dinucleotide phosphate oxidase activity. This study seems to show that red palm oil, because of its richness in antioxidants, would be less deleterious for the heart. ANOVA, followed by Tukey Kramer's multiple comparison test. Statistical analyzes of the data were performed with StatView software (SAS Institute, Cary, NC, USA). The differences observed were considered significant for a p value <0.05. The Bravais-Pearson correlation test was used to evaluate linear regressions; the closer the values are to 1 (in absolute value), the stronger the relationship.
棕榈油长期以来一直被认为是肥胖的罪魁祸首，而这种肥胖会导致心脏纤维化的发生，有几位作者提出了自由基在纤维化反应的病理生理机制中与肥胖有关;因此，本研究的目的是评估NOX2在喂食富含几种植物油脂肪(本研究中为棕榈油)的大鼠心脏纤维化发展中的作用。共有40只年轻雄性Wistar大鼠进行了几种饮食(豆油，红棕榈油和分枝棕榈油，橄榄油和猪油)。实验12周后，麻醉处死大鼠，测定大鼠心脏氧化应激、炎症、间质纤维化等指标。我们的研究表明，食用红棕榈油不会导致氧化应激参数和炎症RNA标记物的过度表达。与对照饮食相比，食用红棕榈油的大鼠心肌尼古丁腺嘌呤二核苷酸磷酸氧化酶的表达没有变化。然而，棕榈油、橄榄和猪油的摄入导致心肌尼古丁腺嘌呤二核苷酸磷酸氧化酶活性的显著变化。这项研究似乎表明，由于富含抗氧化剂，红棕榈油对心脏的危害较小。方差分析，其次是Tukey Kramer多重比较检验。使用StatView软件(SAS Institute, Cary, NC, USA)对数据进行统计分析。观察到的差异以p值<0.05为显著性。采用Bravais-Pearson相关检验评价线性回归;值越接近1(绝对值)，关系越强。
{"title":"Study of isoforms of nicotinamide adenine dinucleotide phosphate oxidase of the heart in a model of rats fed on several vegetable oils","authors":"K. Gervais, Jover Bernard, Badia Eric, Djohan Ferdinand, Reynaud Fabrice, Dere, Luc, Niamke Germaine, Chantal Gauze, M. Absalome, Adeoti F Mansour, -. Camara, C. Massara, Cristol Jean Paul","doi":"10.5897/ajbr2021.1128","DOIUrl":"https://doi.org/10.5897/ajbr2021.1128","url":null,"abstract":"Palm oil has long been incriminated in obesity, and this obesity would be responsible for the development of cardiac fibrosis, several authors have evoked the role of free radicals in the pathophysiological mechanism of the fibrotic response linked to obesity; the aim of this study was therefore to evaluate the profile of NOX2 in the development of cardiac fibrosis in rats subjected to a diet rich in the fat of several vegetable oils, in this case palm oil. A total of forty young male Wistar rats were subjected to several diets (soybean, red and branched palm oil, olive and lard). After twelve weeks of experimentation, the rats were sacrificed after anaesthesia, and the parameters of oxidative stress, inflammation and the level of interstitial fibrosis of the heart were assessed. Our study showed that red palm oil consumption did not lead to overexpression of oxidative stress parameters and inflammatory RNA markers. The expression of myocardial nicotine adenine dinucleotide phosphate oxidase did not change in rats consuming red palm oil compared to the control diet. However, consumption of palm olein, olive and lard resulted in a significant change in myocardial nicotine adenine dinucleotide phosphate oxidase activity. This study seems to show that red palm oil, because of its richness in antioxidants, would be less deleterious for the heart. ANOVA, followed by Tukey Kramer's multiple comparison test. Statistical analyzes of the data were performed with StatView software (SAS Institute, Cary, NC, USA). The differences observed were considered significant for a p value <0.05. The Bravais-Pearson correlation test was used to evaluate linear regressions; the closer the values are to 1 (in absolute value), the stronger the relationship.","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85120659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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