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Submucosal Elastosis of the Right Colon-A Case Report with Review of the Literature 右结肠粘膜下弹性增生1例并文献复习
Pub Date : 2021-01-01 DOI: 10.47829/ajsccr.2021.4204
Al Amin, Andrew J Bain, Jingxin Qiu
Submucosal elastosis of the colon is a rarely reported condition that may resemble colonic polyp and amyloid deposition. We report a case of 68-year-old male who underwent screening for colorectal malignant neoplasm. Multiple sessile polyps along with innumerable firm yellow nodules of varying sizes are identified throughout the right colon. Histopathologically, the nodules are characterized by extensive submucosal accumulation of eosinophilic elastic fibers, positive for elastin stain and negative for Congo red stain. The overall findings are consistent with fibroelastoma. The clinical, microscopic, and immunohistochemical characteristics of the current case are reviewed in detail in this report. Other 25 reported cases between 2004-2019 are summarized and their clinical and pathological features are compared with the current case
结肠粘膜下弹性增生是一种罕见的疾病,它可能类似于结肠息肉和淀粉样蛋白沉积。我们报告一位68岁男性接受结直肠恶性肿瘤筛检。右结肠可见多个无根息肉伴无数大小不一的黄色结节。组织病理学上,结节的特点是粘膜下大量嗜酸性弹性纤维积聚,弹性蛋白染色阳性,刚果红染色阴性。总体结果与纤维弹性瘤一致。本报告详细回顾了本病例的临床、显微镜和免疫组织化学特征。总结2004-2019年报告的25例病例,并将其临床和病理特征与当前病例进行比较
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引用次数: 0
Resuming Business in A COVID Normal Environment 新冠正常环境下恢复业务
Pub Date : 2021-01-01 DOI: 10.47829/ajsccr.2021.31303
Akindeju Mk
1. Abstract Although pandemics of its scale and geographical coverage are not unprecedented as widely claimed, coronavirus continues to pose novel and complex challenges to governments, businesses, and individuals. Governments had and continue to have obligations to respond speedily with both health and economic policies to prevent irrevocable damages to their respective economies and sovereignties-some more successful than others. The speed at which governments responded meant there had to be incremental knowledge on the virus, hence public health handling methodologies and policies morphed from form to form in the face of balancing economic realities with health imperatives, inadequate supplies of personal protective equipment and manpower. Amongst all these, MKPro Engineering Pty Ltd (‘MKPro’) identified a critical oversight as of May 2020-official advice had not recognised that aerosol mode of transmission was clearly feasible and was of grave danger. In our modelling, we mathematically established that coronavirus, at published mass of 33.8kDa and 1million cells/mL cluster density, is about 22billion times lighter than air, and can be air-borne, hence able to travel as aerosol particles under suitable conditions for at least several meters before the aerosols become considerably dispersed. Upon establishing the above, MKPro articulated and suggested behavioural and Engineering solutions that can help businesses recover and safely contemplate resumption to business in a COVID-Normal environment. 2. Introduction As SARS-CoV-22 (and COVID-19) pandemic gripped the world, the attention of governments and businesses turned to the widespread damages it was and is still causing to public and private economies. While they battled with stabilising economies and contemplated recoveries, the attention of professionals including doctors, scientists, researchers, public health managers and engineers were focused on the deterministic programming for such recoveries. Those attentions and interests did not always align. Although similar pandemics, by scale, occurred in 1918-1920 (Jarus, 2020; US CDC, 2019; WHO, 2019), COVID19 pandemic was hyped as unprecedented giving rise to governments wielding sweeping Emergency and Public Health powers with elements of public health responses demonstrating most governments may not have adequately learnt from prior comparable pandemics. The attending challenges which include diminished cognition (Marshal, 2021) [14,15], Long-COVID (Marshall, 2021), human behavioural social fatigue (Petherick et al., 2021) [19], deteriorating mental health (Hampshire et al., 2021) [8], shortages of personal protective equipment (Koehler et al., 2020) [13], and non-compliance to public health orders (Nivette et al., 2020) [18] were exacerbated by limited knowledge on coronavirus epidemiology, and in particular on whether coronavirus is communicable via aerosol mode and from saliva (Hu et al, 2020) [9]. With a view to advising necessary gove
1. 虽然大流行的规模和地理覆盖范围并不像人们普遍认为的那样是前所未有的,但冠状病毒继续给政府、企业和个人带来新的复杂挑战。各国政府过去和现在都有义务迅速作出反应,制定卫生和经济政策,防止对各自的经济和主权造成不可挽回的损害——有些国家比其他国家更成功。各国政府的反应速度意味着对该病毒的了解必须不断增加,因此,面对经济现实与卫生需求之间的平衡,以及个人防护设备和人力供应不足,公共卫生处理方法和政策不断变化。其中,MKPro Engineering Pty Ltd(“MKPro”)在2020年5月发现了一个关键的疏忽——官方建议没有认识到气溶胶传播方式显然是可行的,并且具有严重的危险。在我们的建模中,我们从数学上确定,冠状病毒的公布质量为33.8kDa,簇密度为100万个细胞/毫升,比空气轻220亿倍,可以通过空气传播,因此能够在合适的条件下以气溶胶颗粒的形式传播至少几米,然后气溶胶才会变得相当分散。在建立上述基础上,MKPro阐述并建议了行为和工程解决方案,可以帮助企业恢复并安全地考虑在COVID-Normal环境中恢复业务。2. 随着新冠肺炎(SARS-CoV-22)和新冠肺炎(COVID-19)大流行席卷全球,政府和企业的注意力转向了它过去和现在仍在给公共和私营经济造成的广泛损害。当他们努力稳定经济和考虑复苏时,包括医生、科学家、研究人员、公共卫生管理人员和工程师在内的专业人员的注意力集中在这种复苏的确定性规划上。这些关注和兴趣并不总是一致的。虽然类似的大流行在1918-1920年发生过(Jarus, 2020年;美国疾病预防控制中心,2019;世卫组织,2019年),covid - 19大流行被炒作为前所未有的,导致政府拥有全面的紧急情况和公共卫生权力,而公共卫生应对措施的要素表明,大多数政府可能没有从以前类似的大流行中充分吸取教训。认知能力下降(Marshal, 2021)[14,15]、Long-COVID (Marshall, 2021)、人类行为社交疲劳(Petherick等人,2021)[19]、心理健康恶化(Hampshire等人,2021)[8]、个人防护装备短缺(Koehler等人,2020)[13]、不遵守公共卫生命令(Nivette等人,2020)[18]等挑战因对冠状病毒流行病学的了解有限而加剧。特别是关于冠状病毒是否通过气溶胶模式和唾液传播(Hu et al ., 2020)[9]。为了就合理的工程解决方案向必要的政府机构和部门提供建议,MKPro (Akindeju, 2020-a)的研究人员试图确定冠状病毒可能存在的集群容量的可行范围,并确定气溶胶传播模式是否不仅可行而且实用。
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引用次数: 0
The Clinical Comparison Between Tokyo Guidelines and A Novel Auxiliary Scoring System in Guiding the Urgent Drainage of Acute Cholangitis 东京指南与新型辅助评分系统在指导急性胆管炎紧急引流中的临床比较
Pub Date : 2021-01-01 DOI: 10.47829/ajsccr.2021.3604
Guo Y, M. C., W. X, L. L, Wang Q, Xu Z, Li T, Liu F, L. J., Xiu P
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引用次数: 0
Phalloplasty Due to Complete Peno-Scrotal Amputation: A Report Of Surgical Technique 阴茎-阴囊完全切除致阴茎成形术:外科技术报告
Pub Date : 2020-12-31 DOI: 10.47829/AJSCCR.2021.2405
M. Ozinko, Otobo Of, Otei Oo, Ekpo Rg, I. Isiwele, Ashindoitiang Ja
Total penile reconstruction is a challenging procedure considering the anatomy and physiology of the organ.A lot of penile reconstructions have been done in the past and many options have been considered, yet thereare still problems associated with either function or aesthesis. Many options that were used are still leavingsome dissatisfactory. The authors decided to use the anteromedial thigh flap for penile reconstruction whichis not a common choice for total phalloplasty. The anteromedial thigh flap is a veritable tool in scrotoplasty.Thus, we present the use of double anteromedial thigh flaps for the reconstruction of the penis.
考虑到器官的解剖和生理,阴茎重建是一个具有挑战性的过程。许多阴茎重建在过去已经完成,并考虑了许多选择,但仍然存在与功能或美学相关的问题。我们采用的许多方案仍有一些不尽人意之处。作者决定采用股前内侧皮瓣进行阴茎重建,这是全阴茎成形术中不常见的选择。股前内侧皮瓣是阴囊成形术中一种名副其实的工具。因此,我们提出使用双股前内侧皮瓣重建阴茎。
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引用次数: 0
Resection of a Giant Hepatocellular Adenoma Causing Refractory Hypertension, Stroke, Hyperkalemia, Malnutrition and Mesenteric Ischemia 巨大肝细胞腺瘤切除术引起顽固性高血压、中风、高钾血症、营养不良和肠系膜缺血
Pub Date : 2020-11-13 DOI: 10.47496/nl.ajscr.2020.01.05
S. Kulkarni, Tayler J. James, R. Selby, M. Stapfer
Hepatocellular adenoma is a rare, benign liver neoplasm. Hepatocellular adenomas carry a risk of malignanttransformation and spontaneous bleeding, and giant hepatic adenomas can cause additional morbidity bycompressing important adjacent structures. Surgical resection is recommended for large adenomas and iscurative. We report a case of a 31-year old Hispanic male with a giant 35cm hepatocellular adenoma causingright lung compression/collapse, pulmonary hypertension, mesenteric ischemia, refractory hypertension,and cerebrovascular accident (CVA) due to renal vein compression. Exploratory laparotomy, mediansternotomy, left lobectomy, cholecystectomy and hepatico-jejunostomy were performed. The giantadenoma was successfully removed with the resolution of all associated medical problems and a fullrecovery. Massive liver lesions can be resected safely with adequate exposure and may require mediansternotomy. Multiple medical problems due to compression can be completely reversed with resection ofthese benign but giant lesions. Enucleation of giant adenomas is an acceptable form of treatment for lesionscausing multiple symptoms due to compression and leads to a cure in most cases.
肝细胞腺瘤是一种罕见的良性肝脏肿瘤。肝细胞腺瘤具有恶性转化和自发性出血的风险,巨大的肝腺瘤可通过压迫重要的邻近结构而引起额外的发病率。对于大的腺瘤,建议手术切除,而且是可治愈的。我们报告一例31岁的西班牙裔男性,其巨大的35cm肝细胞腺瘤导致右肺压迫/塌陷、肺动脉高压、肠系膜缺血、难治性高血压和肾静脉压迫所致的脑血管意外(CVA)。行剖腹探查术、胸膜正中切口、左肺叶切除术、胆囊切除术、肝空肠吻合术。巨大腺瘤成功切除,解决了所有相关的医疗问题,完全康复。大面积的肝脏病变可以在适当暴露的情况下安全切除,可能需要胸骨正中切口。由于压迫引起的多种疾病可以通过切除这些良性但巨大的病变而完全逆转。巨大腺瘤的去核是一种可接受的治疗形式,病变引起多种症状,由于压迫,并导致治愈在大多数情况下。
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引用次数: 0
Perineal Endometriosis: What to Do in These Cases - Analysis of 13 Patients 会阴子宫内膜异位症:如何处理这些病例- 13例分析
Pub Date : 2020-09-29 DOI: 10.47496/nl.ajscr.2020.01.03
E. Vargas, I. M. Amaral, S. Lopez, M. Paz, Daniel Chiantera, Jenils Coacuto, B. Eliana, M. Pérez
Objective: To analyse the clinical features of perineal endometriosis (PEM), its treatment and outcome.Methods: Prospective, single-centre study with 13 patients with PEM who were treated between 2011-2018at Domingo Luciani Hospital and mean followed up for 58.4 months. Results: Mean age was 32,2 years.All cases had a history of vaginal delivery with an episiotomy. All complained of perineal pain related tothe menstrual cycle; the perineal mass progressively increased in size and was tender during menstrualperiods. Mean VAS was 7. 69,2% with rectal bleeding. The mean size of the lesion was 3.42 cm. CA125levels were measured in all patients, 3 (23,1%) with abnormal range; all patients were subjected totransvaginal, endoanal ultrasonography (EUS) and FNAB before surgery. Anal sphincter (AS) involvementwas demonstrated by EUS in 46.2% (6). Mean EUS pre-treatment volume 18.98 ml. First, these 6 patientsreceived hormonal therapy based on GnRH and evaluated response. Mean EUS post-treatment volume10.21 ml p < 0.05. Complete local excision was performed on all cases. Mean CCFIS preoperative was 2.46and postoperative 3.01 p=0.01. No major complications or recurrences were noted. Conclusion: PEMpresents with typical clinical features when it involves the AS, it could benefit from first a hormonal therapybefore surgery. EUS is a useful preoperative tool to decide what we should do. The main idea at the time ofsurgery is performed a complete local excision with non-touch AS, and in cases where these aren’t possible,a sphincteroplasty is mandatory with good continence results, minor complications and no recurrences.
目的:分析会阴子宫内膜异位症(PEM)的临床特点、治疗及预后。方法:对2011-2018年在Domingo Luciani医院接受治疗的13例PEM患者进行前瞻性单中心研究,平均随访58.4个月。结果:平均年龄32.2岁。所有病例均有会阴切开术阴道分娩史。所有患者均有与月经周期有关的会阴疼痛;会阴肿块在月经期间逐渐增大并有触痛。VAS平均值为7。69.2%为直肠出血。病灶平均大小为3.42 cm。所有患者均检测ca125水平,3例(23.1%)范围异常;所有患者术前均行阴道超声、肛管超声及FNAB检查。46.2%(6)的患者通过EUS检查发现肛门括约肌(AS)受累。EUS治疗前平均容积为18.98 ml。首先,这6名患者接受基于GnRH的激素治疗并评估疗效。EUS治疗后平均容积10.21 ml, p < 0.05。所有病例均行局部完全切除。术前CCFIS均值为2.46,术后均值为3.01,p=0.01。无重大并发症或复发。结论:当合并AS时,pemen具有典型的临床特征,术前应首先进行激素治疗。EUS是术前决定我们该做什么的有用工具。手术时的主要想法是用非接触式AS进行完全的局部切除,在这些不可能的情况下,括约肌成形术是强制性的,具有良好的控制效果,并发症少,无复发。
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引用次数: 0
Non Traumatic Rupture of Splenic Metastases as the First Presentation of Clinically Occult Disseminated Primary Lung Cancer 非外伤性脾转移破裂是临床隐匿弥散性原发性肺癌的首次表现
Pub Date : 2020-01-01 DOI: 10.47829/ajsccr.2020.2402
Tharmaradinam S, Brits N, Kanthan R
Key Learning Points • Though ruptured aortic aneurysm is one of the commonest causes of sudden hypovolemic shock in an adult male, an urgent abdominal CT angiography is recommended for confirmation of diagnosis as it may occasionally reveal an intact aorta with other unexpected causative factors such as an unsuspected splenic rupture. • Non traumatic splenic rupture is rare and is usually associated with a ‘pathological’ spleen with underlying infectious or neo plastic lesions which are usually primary hemopoietic in nature with secondary metastases being relatively uncommon. • Metastases to the spleen from visceral organs is extremely infrequent (<5%) with breast, lung, pancreas, ovary, melanoma and choriocarcinoma often being attributed as their primary source. • Though lung cancer is a commonly diagnosed cancer in Canada with many being diagnosed at an advanced stage, non-traumatic rupture of splenic metastases is an extremely rare first time clinical presentation of primary occult disseminated lung cancer. 1. Abstract In Canada, lung cancer is one of the most commonly diagnosed cancers and is the leading cause of cancer related death. Unfortunately, more than half of all lung cancers present at an advanced stage and are often metastatic at diagnosis. The common sites of metastases include the brain, bone, liver, adrenals, opposite lung and distant lymph nodes. The spleen, a hemopoietic organ is an extremely uncommon site of metastases. In the setting of lung cancer, splenic metastases occurs in the context of disseminated disease, or uncommonly presents as a solitary metastases that is often detected on radiological image surveillance. Most of these scenarios occur in the background of known lung cancer disease. In this case report, we share a case of non-traumatic rupture of splenic metastases whose clinical presentation mimicked a ruptured abdominal aneurysm. The presentation of non-traumatic rupture of the splenic metastases arising from an occult disseminated primary lung cancer as the first clinical encounter is extremely rare and to our knowledge has not been previously reported. Increased clinical awareness of this extremely uncommon clinical presentation of an underlying common disease is important as rapid diagnosis can significantly reduce major morbidity and mortality. 2. Case Presentation A 63-year-old male presented to the community hospital with a one hour history of sudden onset of central abdominal pain, nausea, vomiting and diarrhea accompanied by shortness of breath. On examination, his abdomen was mildly distended with signs of peritonism. His past medical history included a remote repair of an inguinal hernia and was otherwise unremarkable. While being transferred to a larger referral center for further workup and investigations, he unfortunately went into cardiac arrest requiring cardiopulmonary resuscitation. He was intubated on arrival at the emergency department as he was hemodynamically unstable and in acute hypovolem
•虽然主动脉瘤破裂是成年男性突发性低血容量性休克最常见的原因之一,但建议紧急进行腹部CT血管造影以确认诊断,因为它偶尔可能显示完整的主动脉与其他意想不到的病因,如未预料到的脾破裂。•非外伤性脾破裂是罕见的,通常与“病理性”脾脏相关,并伴有潜在的感染性或新塑性病变,通常是原发性造血损伤,继发性转移相对罕见。•从内脏器官转移到脾脏的情况极为罕见(<5%),乳腺癌、肺癌、胰腺、卵巢、黑色素瘤和绒毛膜癌通常被认为是其主要来源。•虽然肺癌在加拿大是一种常见的癌症,许多被诊断为晚期,非外伤性脾转移破裂是一种极其罕见的原发性隐匿性弥散性肺癌的首次临床表现。1. 在加拿大,肺癌是最常见的癌症之一,也是癌症相关死亡的主要原因。不幸的是,超过一半的肺癌出现在晚期,并且通常在诊断时转移。常见的转移部位包括脑、骨、肝、肾上腺、对侧肺和远处淋巴结。脾脏,一个造血器官,是一个极其罕见的转移部位。在肺癌的情况下,脾转移发生在弥散性疾病的背景下,或罕见地表现为孤立的转移,通常在放射图像监测中被发现。这些情况大多发生在已知肺癌疾病的背景下。在这个病例报告中,我们分享了一个非外伤性脾转移破裂的病例,其临床表现类似于腹动脉瘤破裂。隐匿性播散性原发性肺癌引起的脾转移灶非外伤性破裂是极为罕见的,据我们所知,以前没有报道过。由于快速诊断可以显著降低主要发病率和死亡率,因此提高临床对潜在常见病的这种极为罕见的临床表现的认识非常重要。2. 病例表现一名63岁男性,以突发性中枢性腹痛、恶心、呕吐、腹泻伴呼吸短促1小时就诊于社区医院。经检查,他的腹部轻度肿胀,有腹胀的迹象。他的既往病史包括腹股沟疝的远程修补术,除此之外没有什么特别的。在被转移到一个更大的转诊中心进行进一步的检查和调查时,他不幸出现了心脏骤停,需要心肺复苏。由于血流动力学不稳定和急性低血容量性休克,他在到达急诊科时插管。血管外科咨询怀疑腹主动脉瘤破裂。
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引用次数: 1
Hellp Syndrome 临床上妊娠综合症
Pub Date : 1900-01-01 DOI: 10.47829/ajsccr.2021.3201
Solomons Hd
1.Introduction This is a life threatening disorder thought to be a variant of pre-eclampsia. The two conditions occur during the later stages of pregnancy or after childbirth. 2. Hellp means: Haemolytic Anaemia Elevated Liver Enzymes and Low Platelet Count. 3. Methods Hellp is associated with gestational hypertension and in patients who have pre-eclampsia elevated blood pressure and proteinuria. It is thought to be a malignant clonal stem cell disorder! The patients get headaches, blurred vision, malaise, nausea and vomiting abdominal pain and paraesthesias. Generalized oedema may occur. The liver capsule may rupture with a resultant haematoma. Seizures and coma lead to full blown eclampsia. DIC (Disseminated Intravascular Coagulation) is seen in 20% of cases 84 % of cases go into renal failure. Patients with Hellp may be misdiagnosed increasing the risk of liver failure and morbidity [1]. 4. Results In a patient with Hellp syndrome blood tests should include; full blood count, liver enzymes; urea and electrolytes and creatinine and prothrombin index /international normalized ratio, partial thromboplastin time and fibrin degradation products Lactate dehydrogenase is a marker of haemolysis and albuminuria may be present. D-Dimers are a useful test in the disorder. The platelet count may be low, e.g. < 50000. The coagulation system is thought to be the problem. Fibrin crosslinks the vessels. A microangiopathic haemolytic anaemia results and erythrocytes are destroyed. Thrombocytopaenia results and hepatic ischaemia leads to periportal necrosis. 5. Conclusion The DIC (Disseminated Intravascular Coagulopathy) leads to paradoxical haemorrhage. Seizures should be treated as for eclampsia and fresh frozen plasma, steroids and anti-hypertensives must be given. Fluids (preferably Ringer’s lactate) should be given at the required rate Hepatic haemorrhage must be treated by embolization. The incidence of Hellp is 0.2-0,6% i.e.10 to 20% of pregnancies. With treatment maternal mortality is 1%. Complications include renal failure, subcapsular hepatic haematoma and retinal detachment. Hellp syndrome was discovered in 1982 by Dr. Louis Weinstein [2].
1.这是一种威胁生命的疾病,被认为是先兆子痫的一种变体。这两种情况发生在怀孕后期或分娩后。2. 说明:溶血性贫血,肝酶升高,血小板计数低。方法妊高征与妊娠期高血压及先兆子痫患者血压升高及蛋白尿相关。它被认为是一种恶性克隆干细胞疾病!患者出现头痛、视力模糊、不适、恶心呕吐、腹痛和感觉异常。可发生全身性水肿。肝包膜可能破裂并产生血肿。癫痫发作和昏迷会导致全面的子痫。20%的病例发生弥散性血管内凝血(DIC), 84%的病例发生肾衰竭。help患者可能被误诊,增加肝功能衰竭和发病的风险。4. 结果help综合征患者的血液检查应包括:全血细胞计数,肝酶;尿素和电解质、肌酐和凝血酶原指数/国际标准化比值、部分凝血活酶时间和纤维蛋白降解产物乳酸脱氢酶是溶血和蛋白尿的标志。d -二聚体是一种有用的测试方法。血小板计数可能较低,如< 50000。凝固系统被认为是问题所在。纤维蛋白使血管交联。微血管病变导致溶血性贫血,红细胞被破坏。血小板减少和肝缺血导致门静脉周围坏死。5. 结论弥散性血管内凝血病可导致异位性出血。癫痫发作应与子痫和新鲜冷冻血浆治疗一样,必须给予类固醇和抗高血压药物。应按规定的速率给予液体(最好是乳酸林格氏液)。肝出血必须用栓塞治疗。妊高征发生率为0.2% - 0.6%,即妊娠发生率为10% - 20%。经治疗,产妇死亡率为1%。并发症包括肾功能衰竭,包膜下肝血肿和视网膜脱离。1982年,路易斯·温斯坦博士发现了帮扶综合症。
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引用次数: 0
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