Pub Date : 2024-11-18DOI: 10.1164/rccm.202411-2144ED
Silvia Mongodi, Daniele De Luca
{"title":"Quantitative Lung Ultrasound and Pediatric Critical Care: Any Excuse Not to Use It?","authors":"Silvia Mongodi, Daniele De Luca","doi":"10.1164/rccm.202411-2144ED","DOIUrl":"https://doi.org/10.1164/rccm.202411-2144ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1164/rccm.202410-2045ST
Oleg Epelbaum, Tina Marinelli, Qusay S Haydour, Kelly M Pennington, Scott E Evans, Eva M Carmona, Shahid Husain, Kenneth S Knox, Benjamin J Jarrett, Elie Azoulay, William W Hope, Ashley Meyer-Zilla, M Hassan Murad, Andrew H Limper, Chadi A Hage
Background: The incidence of invasive fungal infections is increasing in immune-competent and immune-compromised patients. An examination of the recent literature related to the treatment of fungal infections was performed to address two clinical questions. First, in patients with proven or probable invasive pulmonary aspergillosis, should combination therapy with a mold-active triazole plus echinocandin be administered vs. mold-active triazole monotherapy? Second, in critically ill patients at risk for invasive candidiasis who are non-neutropenic and are not transplant recipients, should systemic antifungal agents be administered either as prophylaxis or as empiric therapy?
Methods: A multidisciplinary panel reviewed the available data concerning the two questions. The evidence was evaluated, and recommendations were generated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.
Results: A conditional recommendation was made for patients with proven or probable invasive pulmonary aspergillosis to receive either initial combination therapy with a mold-active triazole plus an echinocandin or initial mold-active triazole monotherapy based on low-quality evidence. Further, a conditional weak recommendation was made against routine administration of prophylactic or empiric antifungal agents targeting Candida species for critically ill patients without neutropenia or a history of transplant based on low-quality evidence.
Conclusions: The recommendations presented in these Guidelines are the result of an analysis of currently available evidence. Additional research and new clinical data will prompt an update in the future.
{"title":"Treatment of Invasive Pulmonary Aspergillosis and Preventive and Empirical Therapy for Invasive Candidiasis in Adult Pulmonary and Critical Care Patients. An Official American Thoracic Society Clinical Practice Guideline.","authors":"Oleg Epelbaum, Tina Marinelli, Qusay S Haydour, Kelly M Pennington, Scott E Evans, Eva M Carmona, Shahid Husain, Kenneth S Knox, Benjamin J Jarrett, Elie Azoulay, William W Hope, Ashley Meyer-Zilla, M Hassan Murad, Andrew H Limper, Chadi A Hage","doi":"10.1164/rccm.202410-2045ST","DOIUrl":"https://doi.org/10.1164/rccm.202410-2045ST","url":null,"abstract":"<p><strong>Background: </strong>The incidence of invasive fungal infections is increasing in immune-competent and immune-compromised patients. An examination of the recent literature related to the treatment of fungal infections was performed to address two clinical questions. First, in patients with proven or probable invasive pulmonary aspergillosis, should combination therapy with a mold-active triazole plus echinocandin be administered vs. mold-active triazole monotherapy? Second, in critically ill patients at risk for invasive candidiasis who are non-neutropenic and are not transplant recipients, should systemic antifungal agents be administered either as prophylaxis or as empiric therapy?</p><p><strong>Methods: </strong>A multidisciplinary panel reviewed the available data concerning the two questions. The evidence was evaluated, and recommendations were generated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.</p><p><strong>Results: </strong>A conditional recommendation was made for patients with proven or probable invasive pulmonary aspergillosis to receive either initial combination therapy with a mold-active triazole plus an echinocandin or initial mold-active triazole monotherapy based on low-quality evidence. Further, a conditional weak recommendation was made against routine administration of prophylactic or empiric antifungal agents targeting Candida species for critically ill patients without neutropenia or a history of transplant based on low-quality evidence.</p><p><strong>Conclusions: </strong>The recommendations presented in these Guidelines are the result of an analysis of currently available evidence. Additional research and new clinical data will prompt an update in the future.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1164/rccm.202409-1681ED
Carolyn J Wang, Don D Sin
{"title":"Best in Class: Immunoglobulin G as a Treatable Trait for Exacerbation Prevention in Chronic Obstructive Pulmonary Disease.","authors":"Carolyn J Wang, Don D Sin","doi":"10.1164/rccm.202409-1681ED","DOIUrl":"https://doi.org/10.1164/rccm.202409-1681ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1164/rccm.202410-2048ED
Eszter N Tóth, Jessie van Wezenbeek, Frances S de Man
{"title":"Decoding Sex Differences in Right Ventricular Function through <i>BMPR1A</i>.","authors":"Eszter N Tóth, Jessie van Wezenbeek, Frances S de Man","doi":"10.1164/rccm.202410-2048ED","DOIUrl":"https://doi.org/10.1164/rccm.202410-2048ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1164/rccm.202408-1521RL
Daniele De Luca, Costanza Neri, Barbara Loi, Estefania Ruiz-Gonzales, Luca Bonadies, Eugenio Baraldi, Almudena Alonso-Ojembarrena
{"title":"Simple <i>vs</i> Extended Lung Ultrasound Score to Guide Surfactant Replacement in the First 24h of Life.","authors":"Daniele De Luca, Costanza Neri, Barbara Loi, Estefania Ruiz-Gonzales, Luca Bonadies, Eugenio Baraldi, Almudena Alonso-Ojembarrena","doi":"10.1164/rccm.202408-1521RL","DOIUrl":"https://doi.org/10.1164/rccm.202408-1521RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What Is RSV Infection in Adults?","authors":"Tina V Hartert, Kathleen A Hiltz","doi":"10.1164/rccm.210i10p7","DOIUrl":"10.1164/rccm.210i10p7","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"210 10","pages":"P7-P8"},"PeriodicalIF":19.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15DOI: 10.1164/rccm.v210erratum8
{"title":"Erratum: Who Transmits Tuberculosis to Whom: A Cross-Sectional Analysis of a Cohort Study in Lima, Peru.","authors":"","doi":"10.1164/rccm.v210erratum8","DOIUrl":"10.1164/rccm.v210erratum8","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"210 10","pages":"1280"},"PeriodicalIF":19.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15DOI: 10.1164/rccm.210i10xxxii
{"title":"November 15 Highlight.","authors":"","doi":"10.1164/rccm.210i10xxxii","DOIUrl":"https://doi.org/10.1164/rccm.210i10xxxii","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"210 10","pages":"xxxii-xxxiv"},"PeriodicalIF":19.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15DOI: 10.1164/rccm.v210erratum7
{"title":"Erratum: Digital Spatial Profiling Identifies Distinct Molecular Signatures of Vascular Lesions in Pulmonary Arterial Hypertension.","authors":"","doi":"10.1164/rccm.v210erratum7","DOIUrl":"10.1164/rccm.v210erratum7","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"210 10","pages":"1279-1280"},"PeriodicalIF":19.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1164/rccm.202405-0956IM
Atsuko Shono, Ken Tonai, Shinshu Katayama, Masamitsu Sanui
{"title":"Vigorous Diaphragm Movement Captured by Four-Dimensional Computed Tomography in Quadriplegia Patient.","authors":"Atsuko Shono, Ken Tonai, Shinshu Katayama, Masamitsu Sanui","doi":"10.1164/rccm.202405-0956IM","DOIUrl":"https://doi.org/10.1164/rccm.202405-0956IM","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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