Pub Date : 2024-11-12DOI: 10.1164/rccm.202410-1883VP
Andrew Bush, Grant Waterer
{"title":"World Pneumonia Day: Why Do We Still Need It?","authors":"Andrew Bush, Grant Waterer","doi":"10.1164/rccm.202410-1883VP","DOIUrl":"https://doi.org/10.1164/rccm.202410-1883VP","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1164/rccm.202410-2081ED
Meghan Koo, Miranda Kirby
{"title":"Mucus Plugs: A Treatable Trait for Preventing COPD Exacerbations.","authors":"Meghan Koo, Miranda Kirby","doi":"10.1164/rccm.202410-2081ED","DOIUrl":"https://doi.org/10.1164/rccm.202410-2081ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1164/rccm.202405-1043RL
Sylvia Verbanck, Pieter Boonen, Jef Vandemeulebroucke, Wilfried Cools, Raúl San José Estépar, Eef Vanderhelst
{"title":"Vascular Pruning, Peripheral Air Space Alterations and Carbon Monoxide Transfer in Smokers.","authors":"Sylvia Verbanck, Pieter Boonen, Jef Vandemeulebroucke, Wilfried Cools, Raúl San José Estépar, Eef Vanderhelst","doi":"10.1164/rccm.202405-1043RL","DOIUrl":"https://doi.org/10.1164/rccm.202405-1043RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1164/rccm.202405-0955RL
Andrew J Admon, Michael W Sjoding, Hallie C Prescott, Rishi Chanderraj, Robert P Dickson
{"title":"Estimating the Population-Level Impact of Empiric Anti-Anaerobic Antibiotics among US Adults Hospitalized with Sepsis.","authors":"Andrew J Admon, Michael W Sjoding, Hallie C Prescott, Rishi Chanderraj, Robert P Dickson","doi":"10.1164/rccm.202405-0955RL","DOIUrl":"https://doi.org/10.1164/rccm.202405-0955RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1164/rccm.202404-0869RL
Sashko G Spassov, Lea Streicher, Eva Bohe, Patryk Dzierzawski, Silke Borgmann, Johannes Dinkelaker, Bernd Flamm, Johannes Spaeth, Johannes Schmidt, Stefan Schumann, Christin Wenzel
{"title":"Flow-controlled Expiration Reduces Lung Injury During Assisted Ventilation in Pigs with ARDS.","authors":"Sashko G Spassov, Lea Streicher, Eva Bohe, Patryk Dzierzawski, Silke Borgmann, Johannes Dinkelaker, Bernd Flamm, Johannes Spaeth, Johannes Schmidt, Stefan Schumann, Christin Wenzel","doi":"10.1164/rccm.202404-0869RL","DOIUrl":"https://doi.org/10.1164/rccm.202404-0869RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1164/rccm.202403-0523OC
Gonzalo Hernández, Jose Dianti, Irene Paredes, Francisco Moran, Margarita Marquez, Angel Calle, Laura Colinas, Gadea Alonso, Pilar Carneiro, Guillermo Morales, Fernando SuarezSipmann, Alfonso Canabal, Ewan Goligher, Oriol Roca
Background: The optimal strategy to prevent reintubation in obese patients remains uncertain. We aimed to determine whether noninvasive ventilation (NIV) with active humidification is superior to high-flow nasal cannula (HFNC) in preventing reintubation in obese patients at intermediate risk.
Methods: Randomized controlled trial in two intensive care units in Spain (June 2020‒June 2021). We included patients ready for planned extubation with a body mass index (BMI) >30 and ≤3 risk factors for reintubation. Patients with hypercapnia at the end of the spontaneous breathing trial were excluded. Patients were randomized to undergo NIV with active humidification or HFNC for 48 hours after extubation. The primary outcome was reintubation rate within 7 days after extubation. As a secondary analysis, we performed a post hoc Bayesian analysis using three different priors.
Results: Of 144 patients (median age, 61 [p25-p75 61-67] years; 65 [45%] men), 72 received NIV and 72 HFNC. Reintubation was required in 17 (23.6%) patients receiving NIV and in 24 (33.3%) patients receiving HFNC (difference between groups 9.7 (95%CI: -4.9 ‒ 24.4)). All the secondary analysis showed non-significant differences. In the exploratory Bayesian analysis, the probability of a reduction in reintubation with NIV was 99% (data-driven prior), 90% (minimally informative prior), or 89% (skeptical prior).
Conclusions: Among adult obese critically ill patients at intermediate risk for extubation failure, the rate of reintubation was not significantly lower with NIV than with HFNC. Nevertheless, there is a risk for underpowered results. Clinical trial registration available at www.
{"title":"Humidified Noninvasive Ventilation versus High-Flow Therapy to Prevent Reintubation in Obese Patients: A Randomized Clinical Trial.","authors":"Gonzalo Hernández, Jose Dianti, Irene Paredes, Francisco Moran, Margarita Marquez, Angel Calle, Laura Colinas, Gadea Alonso, Pilar Carneiro, Guillermo Morales, Fernando SuarezSipmann, Alfonso Canabal, Ewan Goligher, Oriol Roca","doi":"10.1164/rccm.202403-0523OC","DOIUrl":"https://doi.org/10.1164/rccm.202403-0523OC","url":null,"abstract":"<p><strong>Background: </strong>The optimal strategy to prevent reintubation in obese patients remains uncertain. We aimed to determine whether noninvasive ventilation (NIV) with active humidification is superior to high-flow nasal cannula (HFNC) in preventing reintubation in obese patients at intermediate risk.</p><p><strong>Methods: </strong>Randomized controlled trial in two intensive care units in Spain (June 2020‒June 2021). We included patients ready for planned extubation with a body mass index (BMI) >30 and ≤3 risk factors for reintubation. Patients with hypercapnia at the end of the spontaneous breathing trial were excluded. Patients were randomized to undergo NIV with active humidification or HFNC for 48 hours after extubation. The primary outcome was reintubation rate within 7 days after extubation. As a secondary analysis, we performed a post hoc Bayesian analysis using three different priors.</p><p><strong>Results: </strong>Of 144 patients (median age, 61 [p25-p75 61-67] years; 65 [45%] men), 72 received NIV and 72 HFNC. Reintubation was required in 17 (23.6%) patients receiving NIV and in 24 (33.3%) patients receiving HFNC (difference between groups 9.7 (95%CI: -4.9 ‒ 24.4)). All the secondary analysis showed non-significant differences. In the exploratory Bayesian analysis, the probability of a reduction in reintubation with NIV was 99% (data-driven prior), 90% (minimally informative prior), or 89% (skeptical prior).</p><p><strong>Conclusions: </strong>Among adult obese critically ill patients at intermediate risk for extubation failure, the rate of reintubation was not significantly lower with NIV than with HFNC. Nevertheless, there is a risk for underpowered results. Clinical trial registration available at www.</p><p><strong>Clinicaltrials: </strong>gov, ID: NCT04125342.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1164/rccm.202406-1206RL
Rachelle Aucoin, Magnus Ekström, Pei Zhi Li, Jean Bourbeau, Wan C Tan, Dennis Jensen
{"title":"Response Bias for Modified Borg 0-10 Numerical Categories without Verbal Descriptors During Assessment of Exertional Symptoms.","authors":"Rachelle Aucoin, Magnus Ekström, Pei Zhi Li, Jean Bourbeau, Wan C Tan, Dennis Jensen","doi":"10.1164/rccm.202406-1206RL","DOIUrl":"https://doi.org/10.1164/rccm.202406-1206RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1164/rccm.202410-2018ED
Philip L Molyneaux, Paolo Spagnolo
{"title":"Targeting Autotaxin and LPA in Pulmonary Fibrosis: Admilparant's Positive Results Show Continued Promise.","authors":"Philip L Molyneaux, Paolo Spagnolo","doi":"10.1164/rccm.202410-2018ED","DOIUrl":"https://doi.org/10.1164/rccm.202410-2018ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fruits Hanging on the Branches of Lung: Pulmonary Epithelioid Hemangioendothelioma.","authors":"Min-Li Lv, Qiang Gao, Yantao Huang, Jian-Quan Zhong","doi":"10.1164/rccm.202405-1011IM","DOIUrl":"https://doi.org/10.1164/rccm.202405-1011IM","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1164/rccm.202406-1110RL
Andrew C Berical, Hirofumi Kiyokawa, Mary Lou Beermann, Daniel Wallman, Gabrielle Cherfane, Victoria Dunphy, Jiehong Pan, Andrew Tilston-Lunel, Xaralabos Varelas, Amjad Horani, Steven L Brody, Darrell N Kotton, Finn J Hawkins
{"title":"Airway Disease Modeling with Gene-edited Human Basal Cell Transplantation.","authors":"Andrew C Berical, Hirofumi Kiyokawa, Mary Lou Beermann, Daniel Wallman, Gabrielle Cherfane, Victoria Dunphy, Jiehong Pan, Andrew Tilston-Lunel, Xaralabos Varelas, Amjad Horani, Steven L Brody, Darrell N Kotton, Finn J Hawkins","doi":"10.1164/rccm.202406-1110RL","DOIUrl":"https://doi.org/10.1164/rccm.202406-1110RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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