Jim M Smit, Jesse H Krijthe, Melanie Lloyd, Antoni Torres, Pierre-François Dequin, Philip A van der Zee
{"title":"From severity-guided to CRP-guided corticosteroid treatment.","authors":"Jim M Smit, Jesse H Krijthe, Melanie Lloyd, Antoni Torres, Pierre-François Dequin, Philip A van der Zee","doi":"10.1093/ajrccm/aamag070","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag070","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Klompas, Majdi Al-Hasan, Mayar Al Mohajer, Robert Colgrove, Shira Doron, Thomas File, Natasha Pettit, Michael Pulia, Sharon Weissman
{"title":"Infectious Diseases Society of America (IDSA) Position Statement: Why IDSA Did Not Endorse the Community-Acquired Pneumonia Guidelines 2025 Update.","authors":"Michael Klompas, Majdi Al-Hasan, Mayar Al Mohajer, Robert Colgrove, Shira Doron, Thomas File, Natasha Pettit, Michael Pulia, Sharon Weissman","doi":"10.1093/ajrccm/aamag065","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag065","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dallas J Smith, George R Thompson, Nathan C Bahr, Neil M Ampel
{"title":"Neglect of Dimorphic Fungi in Community-acquired Pneumonia Guidelines.","authors":"Dallas J Smith, George R Thompson, Nathan C Bahr, Neil M Ampel","doi":"10.1093/ajrccm/aamag066","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag066","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Salton, Jesús Villar, Anna De Nes, Barbara Ruaro, Marco Confalonieri, Paola Confalonieri
{"title":"The overlooked reality of fulminant pneumonia.","authors":"Francesco Salton, Jesús Villar, Anna De Nes, Barbara Ruaro, Marco Confalonieri, Paola Confalonieri","doi":"10.1093/ajrccm/aamag068","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag068","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to Smith et al., Salton et al., Smit et al., and to Kraft and Despotovic.","authors":"Barbara E Jones, Julio A Ramirez","doi":"10.1093/ajrccm/aamag073","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag073","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aravind A Menon, Matthew Moll, Janelle V Pugashetti, Angela L Linderholm, Gabrielle Y Liu, Rachana Krishna, Imre Noth, Gary M Hunninghake, Carol Feghali-Bostwick, Auyon J Ghosh
{"title":"Sex-related transcriptomic differences in idiopathic pulmonary fibrosis.","authors":"Aravind A Menon, Matthew Moll, Janelle V Pugashetti, Angela L Linderholm, Gabrielle Y Liu, Rachana Krishna, Imre Noth, Gary M Hunninghake, Carol Feghali-Bostwick, Auyon J Ghosh","doi":"10.1093/ajrccm/aamag080","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag080","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surya P Bhatt, Gerard J Criner, MeiLan K Han, Jessica Bon, Frank C Sciurba
{"title":"Prevalence of the Phenotype of Lung Hyperinflation and Minimal Emphysema in COPD.","authors":"Surya P Bhatt, Gerard J Criner, MeiLan K Han, Jessica Bon, Frank C Sciurba","doi":"10.1093/ajrccm/aamag064","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag064","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ComPLEX Controversy: Management of alveolar hemorrhage in ANCA-associated vasculitis.","authors":"Lynn A Fussner, Guy N Brock, Rona M Smith","doi":"10.1093/ajrccm/aamag039","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag039","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The respiratory events of birth are even more fascinating than we thought.","authors":"Jennifer L Mueller, David G Tingay","doi":"10.1093/ajrccm/aamag042","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag042","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadia N Hansel, Nirupama Putcha, Han Woo, Ashraf Fawzy, Dan Belz, Wendy Lorizio, Molly Lauver, Ana M Rule, Michelle N Eakin, Kirsten Koehler
Rationale: Indoor particulate matter (PM) is linked to worse respiratory outcomes in adults with chronic obstructive pulmonary disease (COPD). It is unclear if reducing indoor pollutants can improve respiratory health among current smokers.
Objective: This study aimed to assess whether a multi-component environmental intervention to improve home air quality (PM and secondhand smoke (SHS) exposure) improves respiratory morbidity among current smokers with COPD.
Methods: Current smokers with moderate-to-severe COPD were randomized to receive active portable HEPA air cleaners and motivational interviewing (MI) for PM and SHS reduction, respectively; or sham air cleaners without MI. The primary outcome was six-month change in Saint George's Respiratory Questionnaire (SGRQ). Secondary outcomes were respiratory symptoms, exacerbation risk, and lung function.
Main results: Among 121 randomized participants, 99 completed the study. The active intervention resulted in reduced PM levels compared to control, but no reduction in indoor SHS exposure. Those in the active arm showed a clinically and statistically significant improvement in total SGRQ score compared to control (ß -4.4 [95% CI, -8.2 to -0.5]; P = 0.025). Secondary analyses indicated significant improvement in respiratory symptoms (dyspnea and cough) and health status as measured by COPD Assessment Test and clinical COPD questionnaire among the active group (vs. control). There was no significant difference in FEV1 change, sputum symptoms or odds of exacerbations between groups.
Conclusions: This study is the first to demonstrate potential health benefits from an environmental intervention in active smokers with COPD, most likely attributable to PM reduction associated with portable HEPA air cleaner use.
{"title":"Motivational Interviewing and Air Cleaners for Smokers with COPD (MOVE): A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Nadia N Hansel, Nirupama Putcha, Han Woo, Ashraf Fawzy, Dan Belz, Wendy Lorizio, Molly Lauver, Ana M Rule, Michelle N Eakin, Kirsten Koehler","doi":"10.1093/ajrccm/aamag016","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag016","url":null,"abstract":"<p><strong>Rationale: </strong>Indoor particulate matter (PM) is linked to worse respiratory outcomes in adults with chronic obstructive pulmonary disease (COPD). It is unclear if reducing indoor pollutants can improve respiratory health among current smokers.</p><p><strong>Objective: </strong>This study aimed to assess whether a multi-component environmental intervention to improve home air quality (PM and secondhand smoke (SHS) exposure) improves respiratory morbidity among current smokers with COPD.</p><p><strong>Methods: </strong>Current smokers with moderate-to-severe COPD were randomized to receive active portable HEPA air cleaners and motivational interviewing (MI) for PM and SHS reduction, respectively; or sham air cleaners without MI. The primary outcome was six-month change in Saint George's Respiratory Questionnaire (SGRQ). Secondary outcomes were respiratory symptoms, exacerbation risk, and lung function.</p><p><strong>Main results: </strong>Among 121 randomized participants, 99 completed the study. The active intervention resulted in reduced PM levels compared to control, but no reduction in indoor SHS exposure. Those in the active arm showed a clinically and statistically significant improvement in total SGRQ score compared to control (ß -4.4 [95% CI, -8.2 to -0.5]; P = 0.025). Secondary analyses indicated significant improvement in respiratory symptoms (dyspnea and cough) and health status as measured by COPD Assessment Test and clinical COPD questionnaire among the active group (vs. control). There was no significant difference in FEV1 change, sputum symptoms or odds of exacerbations between groups.</p><p><strong>Conclusions: </strong>This study is the first to demonstrate potential health benefits from an environmental intervention in active smokers with COPD, most likely attributable to PM reduction associated with portable HEPA air cleaner use.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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