Pub Date : 2025-10-06DOI: 10.1164/rccm.202506-1373le
Catharina C Moor,Michael Kreuter,Anna-Maria Hoffmann-Vold
{"title":"ILA or ILD in CTD: The Alphabet Soup Continues.","authors":"Catharina C Moor,Michael Kreuter,Anna-Maria Hoffmann-Vold","doi":"10.1164/rccm.202506-1373le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1373le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"5 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Bidirectional Modification Effects Between Non-Optimum Temperatures and Fine Particulate Matter Pollution on Lower Respiratory Infections.","authors":"Jian Lei,Huimeng Liu,Yang Lan,Xi Chen,Jing Wei,Chen Wei,Furong Deng,Xinbiao Guo,Yuewei Liu,Shaowei Wu","doi":"10.1164/rccm.202506-1520rl","DOIUrl":"https://doi.org/10.1164/rccm.202506-1520rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"54 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1164/rccm.202506-1442le
Ryoko Egashira,Daisuke Yamada,Joseph Jacob
{"title":"Patterns, Features and Extents: Radiological Dilemmas in the ATS Statement Approach to Interstitial Lung Abnormalities.","authors":"Ryoko Egashira,Daisuke Yamada,Joseph Jacob","doi":"10.1164/rccm.202506-1442le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1442le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"81 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1164/rccm.202507-1688ed
Rainer Gloeckl
{"title":"Can a Spark Light an Eternal Flame? Lessons from Physical Activity Coaching in COPD.","authors":"Rainer Gloeckl","doi":"10.1164/rccm.202507-1688ed","DOIUrl":"https://doi.org/10.1164/rccm.202507-1688ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"28 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1164/rccm.202508-2056vp
Mattia Nigro,Stefano Aliberti
{"title":"Positioning Dipeptidyl Peptidase-1 Inhibitors in Bronchiectasis: No Drug Is an Island.","authors":"Mattia Nigro,Stefano Aliberti","doi":"10.1164/rccm.202508-2056vp","DOIUrl":"https://doi.org/10.1164/rccm.202508-2056vp","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"21 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1164/rccm.202506-1519le
Xiangxia Zeng
{"title":"The SOOTHE Trial of Camlipixant in RCC: A Cautionary Note on Stratification and Relevance.","authors":"Xiangxia Zeng","doi":"10.1164/rccm.202506-1519le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1519le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"107 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1164/rccm.202507-1727le
Guanyu Yang,Qinjun Chu
{"title":"Methodological Considerations in the Iloprost for Septic Shock Trial.","authors":"Guanyu Yang,Qinjun Chu","doi":"10.1164/rccm.202507-1727le","DOIUrl":"https://doi.org/10.1164/rccm.202507-1727le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"52 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1164/rccm.202507-1793ed
Yukiko Kunitomo,Nirupama Putcha
{"title":"Targeted Lung Denervation in COPD: Threading the Needle of Safe Interventions to Help the Sickest.","authors":"Yukiko Kunitomo,Nirupama Putcha","doi":"10.1164/rccm.202507-1793ed","DOIUrl":"https://doi.org/10.1164/rccm.202507-1793ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"30 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1164/rccm.202407-1410oc
Eun Gyul Kim,Mi Na Kim,Soo-Yeon Park,Chang Hyun Park,Joo Yeon Cho,Byung Chan Ko,Sung Woo Park,Kyung Won Kim,Ho-Geun Yoon,Myung Hyun Sohn
RATIONALEAsthma is a chronic inflammatory airway disease, affected by epigenetic modifications. E1A binding protein p300 (p300) is a pivotal histone acetyltransferase that regulates the transcription of diverse genes.OBJECTIVESWe investigated the role of p300 in regulating immune responses during allergic asthma.METHODSAn allergen-induced asthma model was established in mice with systemic p300 deletion and regulatory T cell (Treg)-specific p300 deletion. Histone acetyltransferase activity and p300 expression were evaluated in asthma-induced mice and biopsy samples from patients with asthma. Next, immune responses of T helper 2 cells and Tregs were investigated. Additionally, chromatin immunoprecipitation- and RNA-sequencing were conducted using the sorted Tregs. Functional studies of guanylate binding protein 5 (GBP5) in Tregs were confirmed through in vitro inhibition and overexpression tests.MEASUREMENTS AND MAIN RESULTSHistone acetyltransferase activity and p300 levels were elevated in mice with asthma. p300 expression was also higher in patients with asthma than in control subjects. Mice with systemic p300 deletion had elevated type-2 immune responses and decreased Treg population and functions. Furthermore, p300 deletion reduced the suppression ability and differentiation potential of Tregs. Allergic inflammation was also exacerbated in mice with Treg-specific p300 deletion. Chromatin immunoprecipitation- and RNA-sequencing revealed GBP5 as a primary target gene of p300 in Tregs. GBP5 overexpression ameliorated the reduction in Treg proliferation caused by p300 depletion.CONCLUSIONSp300 plays a protective role in allergic asthma by enhancing Treg function, partly through GBP5-mediated regulation, thereby suppressing Th2-driven airway inflammation.
{"title":"p300-Dependent Modulation in Regulatory T Cells Plays a Crucial Role in Allergic Asthma.","authors":"Eun Gyul Kim,Mi Na Kim,Soo-Yeon Park,Chang Hyun Park,Joo Yeon Cho,Byung Chan Ko,Sung Woo Park,Kyung Won Kim,Ho-Geun Yoon,Myung Hyun Sohn","doi":"10.1164/rccm.202407-1410oc","DOIUrl":"https://doi.org/10.1164/rccm.202407-1410oc","url":null,"abstract":"RATIONALEAsthma is a chronic inflammatory airway disease, affected by epigenetic modifications. E1A binding protein p300 (p300) is a pivotal histone acetyltransferase that regulates the transcription of diverse genes.OBJECTIVESWe investigated the role of p300 in regulating immune responses during allergic asthma.METHODSAn allergen-induced asthma model was established in mice with systemic p300 deletion and regulatory T cell (Treg)-specific p300 deletion. Histone acetyltransferase activity and p300 expression were evaluated in asthma-induced mice and biopsy samples from patients with asthma. Next, immune responses of T helper 2 cells and Tregs were investigated. Additionally, chromatin immunoprecipitation- and RNA-sequencing were conducted using the sorted Tregs. Functional studies of guanylate binding protein 5 (GBP5) in Tregs were confirmed through in vitro inhibition and overexpression tests.MEASUREMENTS AND MAIN RESULTSHistone acetyltransferase activity and p300 levels were elevated in mice with asthma. p300 expression was also higher in patients with asthma than in control subjects. Mice with systemic p300 deletion had elevated type-2 immune responses and decreased Treg population and functions. Furthermore, p300 deletion reduced the suppression ability and differentiation potential of Tregs. Allergic inflammation was also exacerbated in mice with Treg-specific p300 deletion. Chromatin immunoprecipitation- and RNA-sequencing revealed GBP5 as a primary target gene of p300 in Tregs. GBP5 overexpression ameliorated the reduction in Treg proliferation caused by p300 depletion.CONCLUSIONSp300 plays a protective role in allergic asthma by enhancing Treg function, partly through GBP5-mediated regulation, thereby suppressing Th2-driven airway inflammation.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"9 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1164/rccm.202508-1854le
François Dépret,David Chen,Matthieu Legrand
{"title":"Reply to Yang and Chu: Methodological Considerations in the Iloprost for Septic Shock Trial.","authors":"François Dépret,David Chen,Matthieu Legrand","doi":"10.1164/rccm.202508-1854le","DOIUrl":"https://doi.org/10.1164/rccm.202508-1854le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"6 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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