Pub Date : 2025-10-17DOI: 10.1164/rccm.202508-1894pp
David M G Halpin,Refiloe Masekela,Claus F Vogelmeier,Obianuju B Ozoh,Alvaro A Cruz,Helen K Reddel,Arzu Yorgancıoğlu,Alvar Agusti
{"title":"Addressing the Global Challenges of COPD and Asthma: A Shared Vision from the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) and the Global Initiative for Asthma (GINA).","authors":"David M G Halpin,Refiloe Masekela,Claus F Vogelmeier,Obianuju B Ozoh,Alvaro A Cruz,Helen K Reddel,Arzu Yorgancıoğlu,Alvar Agusti","doi":"10.1164/rccm.202508-1894pp","DOIUrl":"https://doi.org/10.1164/rccm.202508-1894pp","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"58 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Upper Airway Microbiome in Bronchiectasis: Expanding the Landscape of Airway Dysbiosis.","authors":"Wei-Jie Guan,Cui-Xia Pan,Miguel Angel Martinez-Garcia","doi":"10.1164/rccm.202508-2095ed","DOIUrl":"https://doi.org/10.1164/rccm.202508-2095ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"66 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1164/rccm.202507-1683le
Carmen A T Reep,Evert-Jan Wils,Leo Heunks
{"title":"Reply to Zhu et al.: Methodological Clarifications for Early Ventilation Switching.","authors":"Carmen A T Reep,Evert-Jan Wils,Leo Heunks","doi":"10.1164/rccm.202507-1683le","DOIUrl":"https://doi.org/10.1164/rccm.202507-1683le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"53 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1164/rccm.202508-1846le
Huatao Zhou,Desong Yang
{"title":"Biological Heterogeneity and Biomarker-driven Personalization: Advancing MSC Therapy for ARDS.","authors":"Huatao Zhou,Desong Yang","doi":"10.1164/rccm.202508-1846le","DOIUrl":"https://doi.org/10.1164/rccm.202508-1846le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"148 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1164/rccm.202506-1465le
Jianping Zhu,Weixing Zhang,Hui Xie
{"title":"Methodological Clarifications for Early Ventilation Switching.","authors":"Jianping Zhu,Weixing Zhang,Hui Xie","doi":"10.1164/rccm.202506-1465le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1465le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"1 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1164/rccm.202508-1968le
Michael A Matthay,Aartik Sarma,Narges Alipanah-Lechner,Hanjing Zhuo
{"title":"Reply to Zhou and Yang: Biological Heterogeneity and Biomarker-driven Personalization: Advancing MSC Therapy for ARDS.","authors":"Michael A Matthay,Aartik Sarma,Narges Alipanah-Lechner,Hanjing Zhuo","doi":"10.1164/rccm.202508-1968le","DOIUrl":"https://doi.org/10.1164/rccm.202508-1968le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"20 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-14DOI: 10.1164/rccm.202509-2272ed
Jerry A Krishnan
{"title":"The Case for Case-Finding in Asthma and COPD.","authors":"Jerry A Krishnan","doi":"10.1164/rccm.202509-2272ed","DOIUrl":"https://doi.org/10.1164/rccm.202509-2272ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"1 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RATIONALEMycobacterium avium complex (MAC) pulmonary disease presents with heterogeneous clinical phenotypes.OBJECTIVESThis study aimed to elucidate the heterogeneity of MAC pulmonary disease by analyzing gene expression profiles in whole blood cells and identifying factors contributing to its pathogenesis, treatment response, and disease severity.METHODA total of 100 patients with MAC pulmonary disease newly treated with guideline-based therapy (GBT) were analyzed prospectively, and RNA-sequencing was performed on whole blood cells. Unsupervised cluster analysis, differentially expressed gene (DEG) analysis, and logistic least absolute shrinkage and selection operator regression were performed to identify key genes of the severe cluster. The expressions of these genes were validated in mice infected with M. avium bacteria.MEASUREMENTS AND MAIN RESULTSThe cluster analysis identified three distinct patient clusters, each with unique clinical characteristic and treatment responses. Notably, cluster 3 (C3) showed high neutrophil counts, older age, severe disease manifestations, and poor survival, despite sputum culture conversion. DEG analysis identified six neutrophil-related genes, FTH1, C19orf59 (MCEMP1), S100A9, SELL, ISG15, and IFITM1, as characteristic of C3. Furthermore, high expression of these genes correlated significantly with poor survival in both the present cohort and a previously reported cohort of pulmonary nontuberculous mycobacterial disease patients.M. avium infection increased S100A9 expression, particularly in old, but not young, mouse lungs, suggesting that increased S100A9 expression is associated with aging and infection.CONCLUSIONGene expression profiling in MAC pulmonary disease patients identified three distinct clusters, with the most severe cluster characterized by neutrophil activation. Six genes were associated with disease severity and prognosis, though their causal roles require further investigation.
{"title":"Transcriptomic Profiling in Mycobacterium avium Complex Pulmonary Disease Identifies Clusters Linked to Disease Severity and Neutrophil Activation.","authors":"Chio Sakai,Mizu Nonaka,Masashi Matsuyama,Sosuke Matsumura,Masayuki Nakajima,Kodai Ueda,Naoki Arai,Yuko Morishima,Masafumi Muratani,Yukio Ishii,Takefumi Saito,Nobuyuki Hizawa","doi":"10.1164/rccm.202503-0665oc","DOIUrl":"https://doi.org/10.1164/rccm.202503-0665oc","url":null,"abstract":"RATIONALEMycobacterium avium complex (MAC) pulmonary disease presents with heterogeneous clinical phenotypes.OBJECTIVESThis study aimed to elucidate the heterogeneity of MAC pulmonary disease by analyzing gene expression profiles in whole blood cells and identifying factors contributing to its pathogenesis, treatment response, and disease severity.METHODA total of 100 patients with MAC pulmonary disease newly treated with guideline-based therapy (GBT) were analyzed prospectively, and RNA-sequencing was performed on whole blood cells. Unsupervised cluster analysis, differentially expressed gene (DEG) analysis, and logistic least absolute shrinkage and selection operator regression were performed to identify key genes of the severe cluster. The expressions of these genes were validated in mice infected with M. avium bacteria.MEASUREMENTS AND MAIN RESULTSThe cluster analysis identified three distinct patient clusters, each with unique clinical characteristic and treatment responses. Notably, cluster 3 (C3) showed high neutrophil counts, older age, severe disease manifestations, and poor survival, despite sputum culture conversion. DEG analysis identified six neutrophil-related genes, FTH1, C19orf59 (MCEMP1), S100A9, SELL, ISG15, and IFITM1, as characteristic of C3. Furthermore, high expression of these genes correlated significantly with poor survival in both the present cohort and a previously reported cohort of pulmonary nontuberculous mycobacterial disease patients.M. avium infection increased S100A9 expression, particularly in old, but not young, mouse lungs, suggesting that increased S100A9 expression is associated with aging and infection.CONCLUSIONGene expression profiling in MAC pulmonary disease patients identified three distinct clusters, with the most severe cluster characterized by neutrophil activation. Six genes were associated with disease severity and prognosis, though their causal roles require further investigation.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"78 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-14DOI: 10.1164/rccm.202507-1706rl
Sanjay R Patel,Christy J Stitt,Jessie P Bakker,Mark S Aloia,S Mehdi Nouraie
{"title":"Variability in CPAP Adherence Across the United States: Evidence for a Quality Metric.","authors":"Sanjay R Patel,Christy J Stitt,Jessie P Bakker,Mark S Aloia,S Mehdi Nouraie","doi":"10.1164/rccm.202507-1706rl","DOIUrl":"https://doi.org/10.1164/rccm.202507-1706rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"40 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-14DOI: 10.1164/rccm.202504-0878im
Patrick J Kramer,Christine Doherty,Matthew E Exline,Derrick Herman,Nicholas B Nowacki
{"title":"Pulmonary Crystal Deposition Syndrome Related to Clofazimine Therapy.","authors":"Patrick J Kramer,Christine Doherty,Matthew E Exline,Derrick Herman,Nicholas B Nowacki","doi":"10.1164/rccm.202504-0878im","DOIUrl":"https://doi.org/10.1164/rccm.202504-0878im","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"104 7 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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