Therapia Hungarica (English edition)最新文献

Dopamine agonist Bromocriptin tablet has been used in 102 cases, partly for the inhibition of puerperal lactation, partly for the treatment of infertility accompanied by hyperprolactinaemia. On the basis of the clinical results and the changes of PRL level the drug was found to be very effective in both indications. Side-effects necessitating the discontinuance of treatment were not observed.

The effects of Nizoral cream and clotrimazole ointment have been compared under identical experimental conditions in 35 resp. 37 women suffering from mycotic vulvovaginitis. Nizoral tablet was administered as a basic therapy. Significant differences were not observed when comparing the results of the different 10-day long adjuvant therapies. Considering therapeutic action Nizoral cream was found to be equivalent to the successfully used clotrimazole ointment.

The effect of Nitromint sublingual tablet and Nitromint aerosol (EGIS) has been studied in ambulance practice. Both drug forms relieved or controlled the complaints and symptoms, and proved to be effective in a great number of cases. Due to it's easier storage and easier applicability the aerosol is more advantageous than the sublingual tablet. Occasionally the simultaneous use of the two products is also beneficial. Supposedly the indication field of nitroglycerin will be extended in the near future and Nitromint preparations will be used in oxyology also for controlling other clinical conditions in which smooth muscle spasm has a major role.

Paxirasol aerosol applied in daily 3 x 5-puff doses was well tolerated by the examined patients. In the course of the 21-day therapy the laboratory findings did not change-haemopoetic or liver injury was not observed. On two-thirds of the patients the amount of sputum decreased in response to Paxirasol aerosol but the symptoms accompanying expectoration did not change notably. Among the objective respiratory parameters FEV1 values increased and Rtot values decreased. These changes may be observed during the first third of therapy. There was a continuous and linear increase in FEV values characteristic of respiratory pressure conditions. This phenomenon is not characteristic alone of the changes of values of obstructive diseases patients. The authors recommend the use of Paxirasol aerosol for the treatment of respiratory tract disease patients.

Twelve patients suffering from systemic lupus erythematosus (SLE) were treated with piroxicam (Hotemin-EGIS) for 9-18 (mean: 13.7) months. At the beginning, the patients were in a moderately active stage of the disease, 10 patients also received low dose corticosteroid treatment. After the study was completed, clinical and immunological improvement was seen in 10 cases. The average daily dose of prednisolone could be reduced (from 10.5 mg to 5 mg). These patients tolerated the treatment well, no adverse effect was seen. No elevation of serum transaminase, creatinine or change in blood cell count and glomerular filtration rate were observed. Piroxicam, therefore, is recommended for the treatment of mildly active SLE.

Klion ointment has been used for the cleansing of crural ulcer in 28 patients. The results of treatment were compared to a control group of 17 patients treated with another method. In response to metronidazole the ulcers were cleared within 1-3 weeks, discharge ceased, and the accompanying inflammation and pain were also moderated. The starting proliferation and epithelization indicated the favourable action of Klion ointment form the standpoint of the complete wound healing process.

Nizoral cream containing ketoconazole was studied in 56 patients suffering from different dermatomycoses. In cases of uncertain clinical symptoms microscopic examination and cultivation were also performed to establish a diagnosis. According to the author's observations, in the treatment of mycotic skin diseases Nizoral cream proved to be generally as effective as the other currently used antimycotics.

Patients with chronic active B hepatitis entered into an open study of IFN maintenance therapy. They received 3 x 10(6) I.U. INTRON-A by subcutaneous injection three times a week for a 4-month period. Four patients out of ten became HBeAg negative and anti-HBe, which was accompanied by the return of serum liver function tests to normal. In a control group with eleven patients, given only vitamins, no changes were registered in serological and biochemical data. Fever, "flu-like illness", fatigue were the main side-effects observed during the course of IFN therapy, which had not to be discontinued.

The effect of a 3-week treatment with Loderix is examined in an open study in 40 patients suffering from allergic rhinoconjunctivitis. Side-effects, mainly sleepiness, fatigue, weakness, were observed in nearly half of the patients. These were, in general, mild and of a transient character. Treatment had to be stopped in 2 patients due to developed adverse effects. Safety parameters as blood picture, liver function tests, renal function parameters showed no alterations during the study course. During the treatment periods rhinoconjunctivitis symptoms disappeared or significantly decreased in 22 patients out of 40. Moderate effect was registered in 14 patients, and treatment was ineffective in 4 cases. In 6 patients the doses were doubled from the 2nd week of treatment causing an increase in effectivity without a change in side-effect profile.

Angiotensin converting enzyme inhibitor therapy decreases the production of the vasoconstrictive angiotensin II and reduces the degradation of certain kinines of vasodilatator action. Of captopril, enalapril, and lysinopril marketed abroad, only captopril of shorter action is available in Hungary. Angiotensin converting enzyme inhibitors are new means for the therapy of hypertension and congestive heart failure. Captopril seems to be effective at an early stage of heart failure. It slows down or even inhibits the progression of heart failure. New aspects of therapy have been revealed. It may be successfully used in angina pectoris, for the prevention of reperfusion arrhythmias accompanying myocardial infarction, for the treatment of renoparenchimal renal diseases, diabetic nephropathy. The side-effects, interactions, and dosage of angiotensin converting enzyme inhibitors have also been discussed.