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BIOLOGICAL EFFECT OF HESPERIDIN ADMINISTRATION ON ALVEOLAR BONE STRUCTURE IN INDUCED DIABETIC RATS 服用橙皮甙对糖尿病大鼠牙槽骨结构的生物学效应
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2023.164552.1317
Noha Aboshosha, G. Elba, K. Kawana, Amira Eissa
BACKGROUND: Diabetes mellitus (DM) is one of the most common endocrine disorders. It is associated with an elevation in blood glucose levels. Oxidative stress caused by hyperglycemia is central to the occurrence of diabetic complications such as retinopathy, nephropathy and diabetic osteopenia. Alveolar Bone forms the primary support structure of teeth. It’s affected majorly by diabetic osteopenia. Some antidiabetic drugs may also increase the risk of diabetic fractures. Hesperidin is an active flavanone isolated from citrus fruits . OBJECTIVES: The aim of the current study is to evaluate the effect of Hesperidin administration on alveolar bone structure in rats with Streptozotocin-induced diabetes. MATERIALS AND METHODS: Eighteen adult male albino rats will be randomly divided into 3 equal groups: Group I (Control group). Group II (DM group): Rats will be administered Streptozotocin (STZ) to induce DM. Group III (Hesperidin group): Rats with STZ–induced DM will be given Hesperidin via gastric gavage. Rats will be euthanized after 6 weeks. Mandibles will be dissected and prepared for histological evaluation by light and scanning electron microscope. Percentages of Calcium and Phosphorus will be analyzed using EDX . RESULTS: Control group showed normal histological features of the alveolar bone. The diabetic group revealed an irregular outline with severe destruction while the Hesperidin group showed almost normal restoration of the structure of alveolar bone . CONCLUSION: Hesperidin exerted a protective effect on alveolar bone osteoporosis in diabetic rats .
背景:糖尿病(DM)是最常见的内分泌疾病之一。它与血糖水平升高有关。高血糖引起的氧化应激是发生视网膜病变、肾病和糖尿病性骨质减少等糖尿病并发症的核心。牙槽骨是牙齿的主要支撑结构。它主要受糖尿病性骨质减少的影响。一些抗糖尿病药物也可能增加糖尿病性骨折的风险。橙皮苷是一种从柑橘类水果中分离得到的活性黄酮。目的:本研究的目的是评价橙皮苷对链脲佐菌素诱导的糖尿病大鼠牙槽骨结构的影响。材料与方法:18只成年雄性白化大鼠随机分为3组:第一组(对照组)。II组(DM组):给予链脲佐菌素(STZ)诱导DM。III组(橙皮苷组):STZ诱导DM大鼠灌胃给予橙皮苷。6周后对大鼠实施安乐死。下颌骨将被解剖并准备在光镜和扫描电镜下进行组织学评估。用EDX分析钙和磷的百分比。结果:对照组牙槽骨组织学特征正常。糖尿病组牙槽骨轮廓不规则,破坏严重,橙皮苷组牙槽骨结构基本恢复正常。结论:橙皮苷对糖尿病大鼠牙槽骨骨质疏松有保护作用。
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引用次数: 0
3D PRINTED COMPUTER GUIDED Vs CONVENTIAL ARTHROCENTESIS IN THE MANAGEMENT OF TEMPOROMANDIBULAR JOINT INTERNAL DERANGEMENT 3D 打印计算机引导下的假关节切除术在治疗创伤性关节内部切除术中的应用
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2022.166907.1319
Ahmed Fahmy, Nevien Mohamed, Gaafar El Halawani
INTRODUCTION: Temporomandibular disorder (TMD) is a general term that comprises a wide range of clinical problems involving orofacial muscles and joints with the help of patient specific guide we do arthrocentesis as a non-invasive treatment. OBJECTIVE: The aim of this study was to evaluate the efficiency of 3D printed patient customized guides in conjugation with arthrocentesis in treatment of internal derangement of temporomandibular joint followed by PRP injection. MATERIALS AND METHODS: A total of 20 patients were divided into two groups. In group I patients with internal derangement were managed with patient specific guide to perform arthrocentesis in comparison with the conventional technique that was used in group II. The pain intensity, maximum inter-incisal opening and range of jaw movement in lateral and protrusion movement, joint noise, number of needle relocation and duration of the procedure were assessed. RESULTS: No needle relocation was required in the study group in contrast to the control group, with a statistically significant difference (p=0.030). The difference in the operation duration between both groups was statistically significant(p=0.003), with the study group requiring shorter time to conduct the procedure. A statistically insignificant difference was reported regarding the pain intensity, disturbance in jaw function, maximum inter-incisal opening, range in jaw movement, and joint noise. CONCLUSION: It may be concluded from the results of this study that a computer guided patient specific arthrocentesis guide based on a preoperative CT-scan is a reliable and reproducible method for accurate and more robust conduction of the arthrocentesis procedure with minimal modifications and low complication rate.
简介:颞下颌紊乱(TMD)是一个总称,包括广泛的涉及口面部肌肉和关节的临床问题,在患者特定指导下,我们将关节穿刺作为一种非侵入性治疗。目的:本研究旨在评价3D打印患者定制导向器结合关节穿刺治疗颞下颌关节内乱后PRP注射的效果。材料与方法:将20例患者分为两组。在I组中,与II组中使用的常规技术相比,有内部紊乱的患者在患者特定指导下进行关节穿刺。评估疼痛强度、最大切间开口和下颌侧向和前突运动范围、关节噪声、针移位次数和手术持续时间。结果:与对照组相比,研究组无需重新定位针头,差异有统计学意义(p=0.030)。两组手术时间差异有统计学意义(p=0.003),研究组手术时间更短。在疼痛强度、下颌功能障碍、最大切间开口、下颌活动范围和关节噪声方面,统计差异不显著。结论:从本研究的结果可以得出结论,基于术前ct扫描的计算机引导患者特异性关节穿刺指南是一种可靠、可重复的方法,可以准确、更稳健地引导关节穿刺过程,修改最少,并发症发生率低。
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引用次数: 0
EFFECT OF DIFFERENT SINTERING TECHNIQUES ON THE BIAXIAL FLEXURAL STRENGTH AND CRYSTAL STRUCTURE OF MONOLITHIC ZIRCONIA (IN VITRO STUDY) 不同烧结技术对整体氧化锆双轴抗弯强度和晶体结构的影响(体外研究)
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2022.153969.1304
Mohamed Negm, Sanaa Abdel kader, Mona Mohy El Din
INTRODUCTION: For monolithic zirconia restorations to be a viable chair-side treatment option, recent studies are aiming to reduce the sintering time required without altering its properties. OBJECTIVES: This study compared the influence of high-speed sintering, speed sintering and conventional sintering on monolithic zirconia regarding bi-axial flexural strength, phase transformation and dimensional changes after sintering. METHODS: Thirty six monolithic zirconia disc specimens were prepared with the dimensions 12mm x 1.5mm and categorized into 3 groups (n=12) based on the sintering technique: High-speed sintering (HS: 1580 °C, total time is approximately 10 minutes) Speed sintering (SS: 1515 °C, total time is approximately 90 minutes), and Conventional sintering (CS, 1500 °C, total time is approximately 10 h). The ball on ring design was used to determine biaxial flexural strength (BFS). Dimensional changes after sintering was evaluated by digital micrometer (with an accuracy of 0.001 mm). The specimen's crystallography was investigated by x-ray diffraction technique (XRD). RESULTS: All groups exhibited a uniform sintering shrinkage of about 20% in all dimensions. Crystallographic analysis revealed only tetragonal and cubic characteristic peaks. BFS test results showed statistically insignificant difference between conventional (1105.5 ± 55.85MPa), speed (1078.3 ± 56.22 MPa), and high speed (1050.6±53.42 MPa) sintering cycles (p<0.05). CONCLUSION: Speed and high speed cycles can be recommended for sintering of monolithic zirconia in order to reduce fixed prosthetic restoration fabrication times as the changes they induced were within the clinically acceptable ranges .
简介:为了使整体氧化锆修复体成为一种可行的椅子边处理选择,最近的研究旨在减少烧结时间而不改变其性能。目的:比较高速烧结、快速烧结和常规烧结对单片氧化锆的双轴抗折强度、烧结后的相变和尺寸变化的影响。方法:制备尺寸为12mm × 1.5mm的单片氧化锆圆盘试样36个,按烧结工艺分为高速烧结(HS: 1580°C,总时间约10分钟)、高速烧结(SS: 1515°C,总时间约90分钟)和常规烧结(CS: 1500°C,总时间约10小时)3组(n=12)。采用球环设计测定双轴抗折强度(BFS)。用数字千分尺测量烧结后的尺寸变化(精度为0.001 mm)。采用x射线衍射技术(XRD)对试样的晶体形貌进行了研究。结果:所有组在所有尺寸上均表现出约20%的均匀烧结收缩率。晶体分析显示只有四方和立方特征峰。BFS试验结果显示,常规烧结周期(1105.5±55.85MPa)、高速烧结周期(1078.3±56.22 MPa)和高速烧结周期(1050.6±53.42 MPa)之间差异无统计学意义(p<0.05)。结论:在临床可接受的范围内,可推荐高速循环烧结单片氧化锆,以减少固定修复体的制作次数。
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引用次数: 0
REPARATIVE EFFECT OF MELATONIN ON THE MANDIBULAR ALVEOLAR BONE AND GINGIVA OF RATS WITH INDUCED PERIODONTITIS 褪黑素对诱发牙周炎大鼠下颌骨牙槽骨和牙龈的修复作用
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2022.159563.1310
Nouran El-Amrawy, Hanaa Aly, Nesma Khalil, Maha Talaab
BACKGROUND: Periodontitis is a chronic inflammatory disease marked by intricate interactions between periodonto-pathogenic bacteria and the host’s immunity. It has a complicated etiology including bacterial colonization, excessive inflammation, and increased oxidative stress. Due to its antioxidant properties, stimulation of fibroblast proliferation, anti-inflammatory capacity, and bone remodeling capability; melatonin can contribute to ameliorating chronic conditions and can have potential dental applications such as in periodontal disease. AIM
背景:牙周炎是一种慢性炎症性疾病,其特征是牙周致病菌与宿主免疫之间复杂的相互作用。它的病因复杂,包括细菌定植、过度炎症和氧化应激增加。由于其抗氧化性能,刺激成纤维细胞增殖,抗炎能力和骨重塑能力;褪黑素有助于改善慢性疾病,并可能有潜在的牙科应用,如牙周病。目的
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引用次数: 0
SINGLE VISIT REGENERATIVE ENDODONTIC TREATMENT (RET) IN TRAUMATIZED NECROTIC IMMATURE PERMANENT TEETH: A REPORT OF THREE CASES 创伤性坏死未成熟恒牙的单次根管再生治疗(RET):三例病例报告
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2022.155616.1306
Pervine H. Sharaf, Raef A. Sherif, Ashraf Zaazou, Soad Hafez, Rania M. Elbackly
OBJECTIVE: This report is intended to describe three cases treated with single-visit regenerative endodontic therapy in three traumatized immature necrotic permanent maxillary central incisors with periapical lesions. MATERIALS AND METHODS: Three asymptomatic patients presented with traumatized immature necrotic permanent maxillary central incisors with periapical lesions (>7mm) requiring tooth restoration. Teeth responded negatively to percussion, palpation and to both thermal and electric pulp testing. Local anesthesia without vasoconstrictor was given and access cavities were prepared. A single visit regeneration protocol was applied including an irrigation sequence with 20 ml of 2.5% sodium hypochlorite, sterile saline (10 mL), 20 ml of 17% Ethylenediaminetetraacetic acid (EDTA), and finally sterile saline (10 mL). A # 20 K-file was used 2mm beyond the apical foramen to evoke bleeding. Biodentine (Septodont, France) was used as the cervical plug. Glass ionomer was flowed over the capping material then composite resin restoration was accomplished. After 12 months, clinical and radiographic outcomes were assessed using cone beam computed tomography (CBCT) and periapical radiographs. RESULTS: At the end of follow up, two cases were asymptomatic. One case presented with a sinus tract and chronic apical abscess. CBCT analysis revealed thinning of the apical diameter, root thickening and lengthening. The periapical radiolucency decreased in two cases and increased in one. The teeth presented no response to thermal or electric pulp testing. CONCLUSION: Single-visit regenerative endodontic therapy may present questionable clinical and radiographic outcomes for treatment of necrotic immature permanent teeth. Further clinical studies are needed to validate its efficacy.
目的:本报告旨在描述三例创伤性未成熟坏死的上颌中切牙根尖周病变的单次再生根管治疗。材料与方法:3例无症状的上颌中切牙创伤性未成熟坏死,根尖周病变(>7mm),需要修复。牙齿对敲击、触诊和热、电牙髓测试均无反应。给予局部麻醉,不使用血管收缩剂,并准备通道腔。采用单次访问再生方案,包括20 ml 2.5%次氯酸钠、10 ml无菌生理盐水、20 ml 17%乙二胺四乙酸(EDTA)和10 ml无菌生理盐水的冲洗顺序。在根尖孔外2mm处使用20号k锉引起出血。使用Biodentine (septodon, France)作为宫颈塞。用玻璃离聚体覆盖盖层材料,完成复合树脂修复。12个月后,使用锥形束计算机断层扫描(CBCT)和根尖周x线片评估临床和放射学结果。结果:随访结束时,2例无症状。1例表现为窦道及慢性根尖脓肿。CBCT分析显示根尖直径变薄,根增厚和延长。根尖周放射率2例下降,1例增加。牙齿对热牙髓和电牙髓测试没有反应。结论:单次就诊再生牙髓治疗对于坏死的未成熟恒牙的临床和影像学结果可能存在疑问。需要进一步的临床研究来验证其有效性。
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引用次数: 0
Healing of mandibular critical size bone defects in rats using piezoelectric plates: An In-vivo Study 使用压电板愈合大鼠下颌骨临界尺寸骨缺损:体内研究
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2022.152996.1303
Nemat Al Ansary, Abd El Aziz Khalil, Tamer Nassef, hager Abdel Fattah, Riham Fliefel
INTRODUCCTION: "Smart materials" have been introduced as a new concept in bone tissue engineering to improve tissue regeneration and overcome the shortcomings of bone grafts, such as material-related infections, and mechanical failures. Piezoelectric scaffolds are a type of smart material introduced for various biomedical uses such as repair and regeneration of bone tissue. OBJECTIVES: This study aimed to evaluate the effect of piezoelectric plates in the regeneration of bone and healing of the segmental bone defect in the rat mandible in order to compare their effect with titanium plates. Materials and Methods: Forty eight rats weighing 275±30 grams were divided into 2 groups: group I; (titanium group), group II; (PVDF poly(vinylidene fluoride) group). Surgical procedures to place the plates were performed in both groups. After first week twenty four of the rats were euthanized and after eight weeks twenty four the rest of rats were euthanized the mandibles were dissected out and prepared for radiographic examination, light microscopic examination and histomorphometry. RESULTS: Radiographic results showed radio-opacity in the site of the bone defect in both groups Histological results revealed new bone trabeculae in the both groups, however, bone was more dense and mature in the titanium groups. The histomorphometric analysis also showed substantially higher percentage of new bone per field in the titanium groups. CONCLUSIONS: piezoelectric plates could enhance bone healing and be used as a mean of achieving good fixation but still the results were inferior to the results of titanium plates.
简介:“智能材料”作为骨组织工程中的一个新概念被引入,以提高组织再生,克服骨移植的缺点,如材料相关感染和机械故障。压电支架是一种用于多种生物医学用途的智能材料,如骨组织的修复和再生。目的:评价压电板在大鼠下颌骨骨再生和节段性骨缺损愈合中的作用,并与钛板进行比较。材料与方法:体重275±30 g的大鼠48只,随机分为2组:1组;(钛族),II族;(PVDF聚偏氟乙烯)基团)。两组均行手术放置钢板。第1周处死24只大鼠,第8周处死24只大鼠,取出下颌骨,进行x线片、光镜和组织形态学检查。结果:两组骨缺损部位x线片表现为放射线混浊,组织学显示两组骨小梁新生,钛组骨致密、成熟。组织形态计量学分析也显示,钛组每野骨的新骨百分比明显更高。结论:压电板能促进骨愈合,可作为良好固定的手段,但其效果仍不如钛板。
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引用次数: 0
Restoration of an Endodontically Treated First Permanent Molar in a Nine-Year Old Child using Digital Workflow: A case report 使用数字化工作流程修复经根管治疗的九岁儿童第一恒磨牙:病例报告
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2023.250744.1449
N. Aly, Mahmoud Eltaweel
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引用次数: 0
Updates on Pain Control in Pediatric Dentistry: Different Approaches and Technologies 儿童牙科疼痛控制的最新进展:不同的方法和技术
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2023.249383.1447
Rodaina H. Helmy, K. Dowidar
in
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引用次数: 0
EVALUATION OF ACCURACY OF 3-D PRINTED REDUCTION GUIDE IN THE TREATMENT OF ZYGOMATICO MAXILLARY COMPLEX FRACTURES (A RANDOMIZED CONTROLLED CLINICAL TRIAL) 评估三维打印还原指南在治疗上颌骨颧骨复合体骨折中的准确性(随机对照临床试验)
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2022.164614.1318
Mohamed Saber, Sameh Darwish, Ragab Hassan, Mervat M. Khalil
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引用次数: 0
STRAIN ASSESSMENT OF COBALT CHROMIUM VERSUS POLY-ETHER-ETHER-KETONE FOR REINFORCING MANDIBULAR OVERDENTURE ASSISTED BY TWO IMPLANTS (A COMPARATIVE IN-VITRO STUDY) 钴铬与聚醚醚酮在两种种植体辅助下加固下颌覆盖义齿的应变评估(体外对比研究)
Pub Date : 2023-12-01 DOI: 10.21608/adjalexu.2022.150941.1299
Zaid Alganabi, Elsayed Nawar, Mona Saad
INTRODUCTION: Patients with a traditional denture may have difficulty chewing because of the absence of retention. Recently, using two un-splinted implants assisted overdenture to overcome the retention problem. But still Acrylic material has problems; such as lowers impact, fatigue strengths, and fracture. Reinforcement of acrylic denture base to avoid fracture by a variety of materials such as; Metal reinforcement, fillers like carbon fiber, and Poly-Ether-Ether-Ketone (PEEK) is frequently utilized in dentistry and is seen as a viable alternative to traditional materials. AIM OF THE STUDY : Compare between Two different denture base reinforcement materials (CoCr) and (PEEK) in comparison to acrylic denture base on strain around two implant-assisted mandibular overdenture and on ridge area. MATERIALS AND METHODS: 3 epoxy models were used with two implants placed at the canine region. 8 mandibular overdenture were constructed for each group; (group A) Acrylic overdenture without reinforcement, for (group B) and (group c) acrylic overdenture were reinforcement by (CoCr, PEEK) respectively. Six linear strain gauges were used at the mesial and distal of each implant, and under the lower second molars bilaterally. Strain measurements were taken under central and unilateral loading around the two implants and on the ridge regions. RESULTS: No significant difference between all groups upon application of central load 100N on ridges. However, group C showed lower strain values upon application of central and unilateral loading 100N. CONCLUSION: PEEK reinforcement material showed less strain values with favorable stress distribution when compared to Acrylic and cobalt chromium reinforcement material for implant-assisted mandibular overdenture.
简介:传统义齿的患者可能会有咀嚼困难,因为没有固位。最近,使用两个无夹板种植体辅助覆盖义齿克服固位问题。但亚克力材料仍然存在问题;例如降低冲击、疲劳强度和断裂。丙烯酸义齿基托的加固,避免由多种材料等造成断裂;金属增强剂、填充剂如碳纤维和聚醚醚酮(PEEK)经常用于牙科,被视为传统材料的可行替代品。研究的目的:比较两种不同的义齿基托材料(CoCr)和(PEEK)与丙烯酸义齿基托在两个种植辅助下颌覆盖义齿周围和嵴区域的应变。材料与方法:使用3个环氧树脂模型,在犬区放置2个种植体。每组制作8个下颌覆盖义齿;(A组)不加补强的丙烯酸覆盖义齿,(B组)和(c组)分别用(CoCr, PEEK)补强丙烯酸覆盖义齿。在每个种植体的中、远端和双侧第二磨牙下分别使用6个线性应变片。在两个种植体周围和山脊区域的中央和单边载荷下进行应变测量。结果:在脊上施加100N的中心负荷,各组间无显著差异。而C组在施加100N的中央和单边载荷时,应变值较低。结论:与丙烯酸和钴铬增强材料相比,PEEK增强材料用于种植下颌覆盖义齿的应变值较小,应力分布良好。
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引用次数: 0
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Alexandria Dental Journal
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