Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems最新文献

{"title":"Prevalensi Anemia Defisiensi Besi dan Faktor-Faktor yang Memengaruhi pada Anak Balita dengan Gizi Buruk","authors":"Intan Zorena Rezky, Harapan Parlindungan Ringoringo, Roselina Panghiyangani, Edi Hartoyo, Rahmiati Rahmiati","doi":"10.20527/ht.v5i2.6269","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6269","url":null,"abstract":"Abstract: Iron deficiency anemia (IDA) is anemia due to impaired erythrocyte formation due to a lack of iron in the body. This research aims to obtain data on the prevalence of iron-deficient anemia and iron-deficient; and to find out the relationship between children's nutritional status, mother's education/occupation/parity, and family income to the prevalence of iron deficiency anemia experienced by children under five at the Cempaka Health Center Banjarbaru. The method used is analytic observational with a cross-sectional approach. Determination of the sample using a consecutive sampling technique. The sample consisted of 30 children who performed anthropometric examinations and a complete peripheral blood laboratory. Based on the result obtained, it show that the prevalence of non-iron-deficient and iron-deficient anemia were 27%, 10%, and 73%, respectively. The tests carried out in analyzing the data were the chi-square test and Fisher's exact test with a 95% confidence level. The results of the analysis of the relationship between the prevalence of iron deficiency anemia with the nutritional status of children (p=0.195), mother's education (p=0.210), mother's occupation (p=1), mother's parity (p=0.210), and family income (p=0.267). It can be inferred that the prevalence of iron deficiency anemia and the factors that affect children under five are not related (p>0.05). Keywords: iron deficiency anemia, child nutritional status, maternal education, maternal occupation, maternal parity, family’s income Abstrak: Anemia defisiensi besi (ADB) adalah anemia akibat pembentukan eritrosit terganggu karena kurangnya jumlah zat besi dalam tubuh. Penelitian ini bertujuan memperoleh data prevalensi anemia terdefisiensi besi serta terdefisiensi besi; dan mengetahui hubungan status gizi anak, pendidikan/pekerjaan/paritas ibu, dan penghasilan keluarga terhadap prevalensi anemia defisiensi besi yang dialami anak balita di Puskesmas Cempaka Banjarbaru. Metode yang digunakan yaitu observasional analitik dengan pendekatan cross-sectional. Penentuan sampel menggunakan consecutive sampling technique. Sampel berjumlah 30 anak yang melakukan pemeriksaan antropometri, dan laboratorium darah tepi lengkap. Berdasarkan hasil penelitian menunjukkan bahwa prevalensi anemia terdefisiensi besi dan terdefisiensi besi berturut-turut yaitu 27%, 10% dan 73%. Uji yang dilakukan dalam menganalisis data yaitu chi-square test dan Fisher’s exact test dengan confidence level 95%. Hasil analisis hubungan antara prevalensi anemia defisiensi besi dengan status gizi anak (p=0,195), pendidikan ibu (p=0,210), pekerjaan ibu (p=1), paritas ibu (p=0,210), dan penghasilan keluarga (p=0,267). Dapat disimpulkan bahwa antara prevalensi anemia defisiensi besi dengan faktor-faktor yang mempengaruhi balita tidak saling berhubungan (p>0,05). Kata-kata kunci: anemia defisiensi besi, status gizi anak, pendidikan ibu, pekerjaan ibu, paritas ibu, penghasilan keluarga","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84090451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambaran Pemberian Ace Inhibitor atau Angiotensin Receptor Blocker pada Pasien Gagal Jantung di RSUD Ulin Banjarmasin","authors":"Nurazizah Yunus, Dwi Laksono Adiputro, Agung Biworo, Mohammad Rudiansyah, Oski Illiandri","doi":"10.20527/ht.v5i2.6276","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6276","url":null,"abstract":"Abstract: Heart failure is a clinical syndrome caused by impaired ventricular filling due to structural damage to the structure and function of the myocardium. At least 26 million people worldwide affected by heart failure and its prevalence is increasing. Treatment of heart failure, medical and non-medical therapy guidelines have been prepared as a guide and recommendation for doctors in providing therapy. There are various classes of drugs given in the treatment of heart failure, one of which is ACE Inhibitors and Angiotensin Receptor Blockers. The use of ACE inhibitors and angiotensin receptor blockers from several large clinical trials is believed to improve symptoms, reduce hospitalizations, and improve quality of life in heart failure patients. The aim of this study is to describe the administration of ACE Inhibitors or Angiotensin Receptor Blockers to Heart Failure Patients at Ulin Hospital Banjarmasin. This research is using descriptive research method. The research data is taken from the form of outpatient medical records of heart failure patients at Ulin Hospital Banjarmasin for the period February-July 2020. Total sampling method is used to collecting the data for this research. From this study, it shown that the highest percentage of heart failure patients was 72.73% male and aged 19-59 years at 67.27%. Drug therapy given from 165 samples showed that the most frequently administered drug was loop diuretic drug 75.15%. The result of this study is that the administration of the ACE inhibitor group of 23.03% was the most given ramipril 89.47%. The most giving of ARB group 52.73% is candesartan 98.85%. Keywords: ACE inhibitor, angiotensin receptor blocker, heart failure Abstrak: Gagal jantung merupakan sindrom klinis yang dipicu  oleh gangguan pengisian ventrikel karena terjadi kerusakan struktur pada stuktur dan fungsi miokardium. Gagal jantung termasuk penyakit global dengan jumlah penderita ditaksir sejumlah 26 juta orang diseluruh dunia dan prevalensinya terus meningkat. Penyembuhan gagal jantung juga telah memiliki susunan pedoman terapi medikamentosa maupun non medikamentosa sebagai rujukan dan rekomendasi bagi dokter dalam pemberian terapi. Terdapat berbagai macam golongan obat yang diberikan untuk penanganan dan pengobatan gagal jantung, satu diantaranya ialah ACE Inhibitor dan Angiotensin Receptor Blocker. Penggunaan ACE Inhibitor dan Angiotensin Receptor Blocker dari beberapa uji klinis besar diyakini dapat memperbaiki gejala, mengurangi rawat inap, dan meningkatkan kualitas hidup pada penderita gagal jantung. Tujuan dari penelitian ini adalah untuk mendeskripsikan pemberian ACE Inhibitor atau Angiotensin Receptor Blocker pada pasien Gagal Jantung di RSUD Ulin Banjarmasin. Pada penelitian ini digunakan metode deskriptif dan data penelitian yang digunakan berupa rekam medik pasien gagal jantung rawat jalan di RSUD Ulin Banjarmasin periode Februari-Juli 2020. Pengambilan data dilakukan dengan metode total sampling. Hasil studi men","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84692072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profil Hematologi pada Anak dengan Suspek Covid-19 di RSD Idaman Banjarbaru Tahun 2020 – 2021","authors":"Sarah Nur Azizah, Roselina Panghiyangani, Harapan Parlindungan Ringoringo, Edi Hartoyo, Rahmiati Rahmiati","doi":"10.20527/ht.v5i2.6274","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6274","url":null,"abstract":"Abstract: Corona virus disease (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 affects all age groups from neonates to the elderly. Haematological profile have been used as important diagnostic and prognostic indicators in COVID-19. The aim of this study is to determine the hematological parameters including erythrocytes, haemoglobin (Hb), hematocrit, Mantzer index (IM), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), leukocytes (type count: basophils, eosinophils, band neutrophils, segments neutrophil, lymphocytes, monocytes), platelets, and Neutrofil Limphocytes Ratio (NLR) in children with suspected COVID 19 at Idaman Hospital Banjarbaru 2020-2021. This study is done using descriptive retrospective method of the suspected COVID-19 pediatric patients. The data used on this study is medical records of the pediatric patients with suspected COVID-19 at Idaman Hospital Banjarbaru 2020-2021. The results showed that children with suspected COVID-19 had normal values of the hematological parameters including RBC 69.81%, Hb 69.8%, hematocrit 73.5%, MCV 67.92%, MCH 58.49%, MCHC 84.90%, leukocytes 67.92%, basophils 98.11%, platelets 69.81% and RNL 66.03%. The decrease in value occurred in the eosinophil parameter as much as 62.26%, bands neutrophils 88.6% and segment neutrophils 45.28%. An increase in the value occurred in the hematological parameters of lymphocytes as much as 41.5%, monocytes 49.05%, and Mantzer index 92.47%. Keywords: children, COVID-19, haematology profile Abstrak: Corona virus disease (COVID-19) merupakan penyakit menular yang diakibatkan Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 menyerang semua kelompok usia dari neonatus hingga lanjut usia. Parameter hematologi penting dalam mendiagnosis COVID-19 dan menilai prognosis pasien. Tujuan dilaksanakannya penelitian ini untuk mengetahui profil hematologi, meliputi eritrosit, hemoglobin (Hb), hematocrit, Indeks Mantzer (IM), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), leukosit (hitung jenis: basofil, eosinofil, neutrofil batang, neutrofil segmen, limfosit, monosit), trombosit, dan Rasio Neutrofil Limfosit (RNL) pada anak dengan suspek COVID-19 di RSD Idaman Banjarbaru 2020-2021. Rancangan penelitian ini menggunakan metode penelitian deskriptif retrospektif, menggunakan data rekam medis pasien anak dengan suspek COVID-19 di RSD Idaman Banjarbaru Tahun 2020-2021. Hasil penelitian menunjukkan bahwa anak dengan suspek COVID – 19 lebih banyak memiliki nilai normal pada parameter hematologi RBC sebanyak 69,81%, Hb 69,8%, hematokrit 73,5%, MCV 67,92%, MCH 58,49%, MCHC 84,90%, leukosit 67,92%, basofil 98,11%, trombosit 69,81% dan RNL 66,03%. Penurunan nilai terjadi pada parameter eosinofil sebanyak 62,26%, neutrofil batang 88,6% dan neutrofil segmen 45,28%. Pe","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82052772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature Review: Pengaruh Pemberian Mecobalamin terhadap Perbaikan Klinis Pasien dengan Neuropati Perifer","authors":"Dyah Septy Tri Christanty, Pagan Pambudi, Pandji Winata Nurikhwan, Muhammad Welly Dafif, Mohammad Bakhriansyah","doi":"10.20527/ht.v5i2.6292","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6292","url":null,"abstract":"Abstract: Peripheral neuropathy is a disorder of peripheral nerve function. It could be classified into 3 namely, mononeuropathy, mononeuropathy multiplex, and polyneuropathy. Mecobalamin is an active analog of vitamin B12 used in the treatment of peripheral neuropathy. It is used as an analgesic and increases nerve conduction provide neuronal protection by promoting the regeneration and maintenance of nerve cell function. This literature review was made to determine whether the administration of mecobalamin could provide clinical improvement in peripheral neuropathy patients. The data used was obtained by searching articles on PubMed, Science Direct, and Google Scholar. The articles used were articles with the year of publication from 2011-2021. A total of 6 articles would be reviewed after the search and selection were processed. The 6 existing articles showed that mecobalamin had an influence on the clinical improvement of peripheral neuropathy caused by entrapment, diabetes, heredity, and inflammation. The clinical improvement was a decrease in pain scores, decreased range of motion, grip strength, and reduced weakness in the distribution of affected nerves. Keywords: vitamin B12, mecobalamin, peripheral neuropathy Abstrak: Neuropati perifer merupakan suatu kondisi gangguan pada fungsi saraf perifer. Neuropati perifer dapat dibagi menjadi 3 jenis yaitu, mononeuropati, mononeuropati multipleks dan polineuropati. Mecobalamin merupakan bentuk analog aktif vitamin B12 yang digunakan pada terapi neuropati perifer. Mecobalamin dapat digunakan sebagai analgetik, untuk meningkatkan konduksi saraf serta menjadi proteksi neuronal dengan mendorong regenerasi dan pemeliharaan fungsi sel saraf. Literature review ini dibuat untuk mengetahui apakah pemberian mecobalamin dapat memberikan perbaikan klinis pada pasien neuropati perifer. Data yang digunakan dalam kajian ini didapatkan dengan melakukan penelurusan artikel di PubMed, Science Direct, dan Google Scholar. Artikel yang digunakan adalah artikel dengan tahun publikasi dari 2011-2021. Sebanyak 6 artikel akan dikaji setelah proses pencarian dan seleksi. Dari 6 artikel yang ada, semuanya menunjukan bahwa mecobalamin memiliki pengaruh dalam perbaikan klinis neuropati perifer yang disebabkan oleh entrapment, diabetik, herediter dan peradangan. Perbaikan klinis tersebut diantaranya adalah penurunan skor nyeri, penurunan keterbatasan gerak, kekuatan menggenggam, dan mengurangi rasa kelemahan pada bagian yang terdistribusi oleh saraf yang terganggu. Kata-kata kunci: vitamin B12, mecobalamin, neuropati perifer","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87917594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Pengetahuan dan Sikap tentang Anemia dengan Perilaku Pencegahan Anemia pada Remaja Puteri di SMAIT Ukhuwah Banjarmasin","authors":"Muhammad Sultan Izdihar, Meitria Syahadatina Noor, Istiana Istiana, Juhairina Juhairina, Nika Sterina Skripsiana","doi":"10.20527/ht.v5i2.6278","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6278","url":null,"abstract":"Abstract: Anemia is a medical condition in which the amount of red blood cells or hemoglobin is lesser than normal. The lack of knowledge about anemia in adolescent girls makes many students have poor eating patterns, resulting in poor anemia prevention behavior as well. The aim of this study was to explain the correlation between knowledge and attitudes about anemia with preventive behavior in adolescent girls at SMAIT Ukhuwah Banjarmasin. The research design was analytic observational with a cross sectional approach using the chi-square test. Sampling using purposive sampling technique with a total sample of 43 students who meet the inclusion and exclusion criteria. The results of the study showed 27 people (63%) had good knowledge and 16 people (37%) had bad knowledge. The majority of 20 female students (46%) have good knowledge and have positive preventive behavior. The correlation between knowledge and prevention behavior has a p value of 0.000 with a PR of 3.1339286. From these result, it can be deduced that there is a significant (p value <0.05) There are 28 respondents (65%) who have a positive attitude with good preventive behavior as many as 20 respondents (46%) and less behavior as many as 8 people (19%). The correlation between attitude and behavior to prevent anemia has p-value = 0.001 with PR = 2.8. between knowledge and attitudes with anemia prevention behavior at SMAIT Ukhuwah Banjarmasin. Keywords: anemia, knowledge, attitude, behavior of  prevention Abstrak: Anemia merupakan sebuah keadaan medis di mana kadar hemoglobin atau sel darah merah dalam tubuh berada di bawah normalnya. Minimnya pengetahuan tentang anemia remaja puteri membuat banyak siswi yang memiliki pola makan yang kurang baik sehingga terjadi sikap perilaku pencegahan anemia yang kurang baik. Penelitian ini ditujukan untuk menjelaskan korelasi antara sikap dan wawasan tentang anemia dengan tindakan antisipasi pada remaja puteri di SMAIT Ukhuwah Banjarmasin. Metode rancangan penelitian adalah observasional analitik melalui pendekatan cross sectional, lantas dianalisis menggunakan uji chi-square. Teknik purposive sampling digunakan untuk mendapatkan jumlah sampel sebanyak 43 orang siswi yang memenuhi kriteria inklusi dan eksklusi. Hasil dari penelitian menunjukan 27 orang (63%) mempunyai pengetahuan baik dan 16 orang (37%) memiliki pengetahuan buruk. Mayoritas siswi 20 orang (46%) memiliki pengetahuan baik dan berprilaku pencegahan positif. Hubungan pengetahuan dan perilaku pencegahan memiliki p-value sebesar 0,000 dengan PR  sebesar 3,1339286. Simpulan yang didapat dari hasil tersebut adalah terdapat keterkaitan yang bermakna (p value <0,05) Terdapat 28 responden (65%) mempunyai sikap positif dengan perilaku pencegahan baik sebanyak 20 responden (46%) dan perilaku kurang sebanyak 8 orang (19%). Keterkaitan antara sikap dengan perilaku pencegahan anemia memiliki p-value = 0,001 dengan PR=2,8.  antara wawasan dan sikap dengan tindakan pencegahan anemia di SMAIT Ukhuwa","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91133314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perbedaan Rasio Neutrofil Limfosit pada Kanker Serviks Tipe Karsinoma Sel Skuamosa dan Tipe Adenokarsinoma","authors":"Said Nur Ikhsan Fachir, Hariadi Yuseran, F. Hendriyono","doi":"10.20527/ht.v5i2.6280","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6280","url":null,"abstract":"Abstract: Cervical cancer is a malignancy and one of the leading causes of death in women. The most common cell types in cervical cancer are squamous cell carcinoma (SCC) (75%) and adenocarcinoma (20%) and the rest are other types (5%). The progression of malignancy can be influenced by the immune system of lymphocytes and neutrophils. The neutrophil lymphocyte ratio is closely related to progression as well as a prognostic marker. A high neutrophil to lymphocyte ratio correlates with a poor patient's prognosis and conversely, the lower the NLR, the better the prognosis. The results obtained 117 research subjects including 88 subjects of cervical cancer type SCC and 29 subjects of adnocarcinoma type cancer recorded at the medical record installation of Ulin Hospital Banjarmasin Period January - December 2019 and as many as 58 subjects (49.7%) met the inclusion criteria including 88 subjects. randomized to 29 subjects (50%) with SCC type and 29 subjects (50%) with adenocarcinoma type. SCC type cervical cancer has a median of 3.37 with a minimum value of 0.77 and a maximum value of 10.98 and adenocarcinoma type has a median of 2.55 with a minimum value of 0.59 and a maximum value of 16.70. The ratio of neutrophil lymphocytes between SCC types and adenocarcinoma types had a p value > 0.05 (0.301). The neutrophil to lymphocyte ratio between types had no significant difference. Keywords: Cervical cancer, NLR, Type SCC and adenocarcinoma Abstrak: Kanker serviks adalah keganasan salah satu penyebab kematian pada wanita. Jenis tipe sel pada kanker serviks paling umum adalah tipe karsinoma sel skuamosa (KSS) (75%) dan tipe adenokarsinoma (20%) dan sisanya merupakan tipe-tipe lain (5%). Progresifitas keganasan dapat dipengaruhi oleh sistem imun limfosit dan neutrofil. Rasio neutrofil limfosit berkaitan erat dengan progresifitas sekaligus penanda prognosis. Rasio Neutrofil Limfosit yang tinggi berkorelasi dengan buruknya prognosis pasien dan sebaliknya semakin rendah RNL maka semakin baik prognosisnya. Hasil penelitian didapatkan 117 subjek penelitian yang meliputi 88 subjek kanker serviks tipe KSS dan 29 subjek kanker tipe adnokarsinoma yang terdata di Instalasi rekam medik RSUD Ulin Banjarmasin Periode Januari – Desember 2019 dan sebanyak 58 subjek (49,7%) memenuhi kriteria inklusi diantaranya 88 subjek di random menjadi 29 subjek (50%) tipe KSS dan 29 subjek (50%) tipe adenokarsinoma. Kanker serviks tipe KSS mempunyai median 3,37 dengan nilai minimun 0,77 dan nilai maksimum 10,98 dan tipe Adenkarsinoma mempunyai median 2,55 dengan nilai minimun 0,59 dan nilai maksimum 16,70. Rasio neutrofil limfosit antar tipe KSS dan tipe adenokarsinoma memiliki nilai p > 0,05 (0,301). Rasio neutrofil limfosit antar tipe memiliki perbedaan yang tidak bermakna. Kata-kata kunci: Kanker serviks, RNL, Tipe KSS dan adenokarsinoma","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85942639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profil Hematologi pada Bayi Baru Lahir dari Ibu Suspek Covid-19 di RSD Idaman Banjarbaru Tahun 2020-2021","authors":"Ellen Jovita Tjitradi, Harapan Parlindungan Ringoringo, Roselina Panghiyangani, Edi Hartoyo, Rahmiati Rahmiati","doi":"10.20527/ht.v5i2.6275","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6275","url":null,"abstract":"Abstract: Coronavirus Disease 2019 (COVID-19) is a disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and it is highly contagious. This study aims to determine the hematological profile which includes erythrocytes (RBC), RDW, Hb, hematocrit, MCV, MCH, MCHC, leukocytes (leukocyte differential Count: basophils, eosinophils, neutrophils, lymphocytes, monocytes), platelets, and NLR in newborns from mothers with suspected COVID-19 at the Idaman Hospital Banjarbaru 2020-2021. This research method is descriptive retrospective with data collection through patient medical records. The sampling technique is purposive sampling. In this study, a total sample of 83 neonates from pregnant women with suspected COVID-19 was obtained. However, from the 83 sample, the sample that has hematological profile data and meets the criteria is 69 sample. The results showed that 42 neonates (62,69%) with reactive IgM tests, and 51 neonates (76,12%) with nonreactive IgG tests. In the distribution of the hematological profile of newborns from mothers with suspected COVID-19, found an increase NLR in 33 neonates (47,83%), an increase hemoglobin in 8 neonates (11,59%), an increase hematocrit in 10 neonates (14,49%), an increase MCV in 8 neonates (11,59%), and decrease MCHC in 8 neonates (11,59%). Keywords: hematology profile, newborns, suspected COVID-19 Abstrak: Coronavirus Disease 2019 (COVID-19) adalah penyakit yang disebabkan oleh virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) dan sangat menular. Penelitian ini bertujuan untuk mengetahui profil hematologi yang meliputi eritrosit (RBC), RDW, Hb, hematokrit, MCV, MCH, MCHC, leukosit (hitung jenis : basofil, eosinofil, neutrofil, limfosit, monosit), trombosit, dan NLR pada bayi baru lahir dari ibu suspek COVID-19 di RSD Idaman Banjarbaru Tahun 2020-2021. Metode penelitian ini adalah deskriptif retrospektif dengan pengambilan data melalui rekam medis pasien. Teknik pengambilan sampel adalah purposive sampling. Dalam penelitian ini didapatkan total sampel 83 neonatus dari ibu hamil dengan suspek COVID-19. Namun, dari 83 sampel tersebut, sampel yang memiliki data profil hematologi dan memenuhi kriteria berjumlah 69 sampel. Hasil penelitian menunjukkan pada pemeriksaan rapid test IgM neonatus ditemukan hasil reaktif sebanyak 42 neonatus (62,69%) dan rapid test IgG ditemukan hasil non reaktif sebanyak 51 neonatus (76,12%). Distribusi profil hematologi bayi baru lahir dari ibu suspek COVID-19 ditemukan peningkatan NLR sebanyak 33 neonatus (47,83%), peningkatan hemoglobin sebanyak 8 neonatus (11,59%), peningkatan hematokrit sebanyak 10 neonatus (14,49%), peningkatan MCV sebanyak 8 neonatus (11,59%), dan penurunan MCHC sebanyak 8 neonatus (11,59%). Kata-kata kunci: profil hematologi, bayi baru lahir, suspek COVID-19","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82281201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perbedaan Rasio Neutrofil Limfosit Kanker Serviks Tipe Karsinoma Sel Skuamosa Berdasarkan Diferensiasi","authors":"Ghaitsa Zahira Shofa, Hariadi Yuseran, F. Hendriyono","doi":"10.20527/ht.v5i2.6290","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6290","url":null,"abstract":"Abstract: Cervical cancer has several cell types, squamous cell carcinoma, adenocarcinoma and others. The level of progression of cervical cancer is determined by the degree of cell differentiation, which is classified into well, moderate and poor differentiation. The neutrophil lymphocyte ratio (NLR) can assess the progression of cervical cancer. The higher the NLR, the higher the level of progression and the worse the degree of cell differentiation. This research is an analytical study using secondary data. The results obtained were 88 cervical cancer subjects with squamous cell carcinoma type and only 41 subjects (46,6%) included in inclusion criteria of this study. In this study, there were 9 subjects of cervical cancer squamous cell carcinoma type with well-differentiated (22,0%), 26 subjects with moderately differentiated (63,5%) and 6 subjects with poorly differentiated (14,5%). The results of NLR for cervical cancer squamous cell carcinoma type well-differentiated has a mean of 1,5 with standard deviation of 1,2. The results of NLR for cervical cancer squamous cell carcinoma type moderately-differentiated has a mean of 3,4 with standard deviation of 2,3. The results of NLR for cervical cancer squamous cell carcinoma type poorly-differentiated has a mean of 5,5 with standard deviation of 3,7. Conclusion from this study is there was a significant difference of NLR in cervical cancer squamous cell carcinoma type in each differentiation. Keywords: cervical cancer squamous cell carcinoma type; well, moderately and poorly differentiated; NLR Abstrak: Kanker serviks mempunyai beberapa tipe sel, yaitu tipe karsinoma sel skuamosa, adenokarsinoma dan lain-lain. Tingkat progresivitas kanker serviks ditentukan dengan derajat diferensiasi sel, yang dibedakan menjadi diferensiasi baik, sedang dan buruk. Rasio neutrofil limfosit (RNL) dapat menilai progresivitas kanker serviks. Semakin tinggi RNL, maka semakin tinggi juga tingkat progresivitasnya dan derajat diferensiasi selnya semakin buruk. Penelitian ini bersifat studi analitik dengan menggunakan data sekunder. Hasil penelitian diperoleh 88 subjek kanker serviks tipe karsinoma sel skuamosa dan hanya 41 subjek (46,6%) yang memenuhi kriteria inklusi penelitian. Pada penelitian ini, terdapat 9 subjek kanker serviks tipe karsinoma sel skuamosa diferensiasi baik (22,0%), 26 subjek diferensiasi sedang (63,5%) dan 6 subjek diferensiasi buruk (14,5%). Hasil data RNL pada kanker serviks tipe karsinoma sel skuamosa diferensiasi baik memiliki rerata 1,5 dengan simpang baku 1,2. Hasil data RNL pada kanker serviks tipe karsinoma sel skuamosa diferensiasi sedang memiliki rerata 3,4 dengan simpang baku 2,3. Hasil data RNL kanker serviks tipe karsinoma sel skuamosa diferensiasi buruk memiliki rerata 5,5 dengan simpang baku 3,7. Kesimpulannya terdapat perbedaan bermakna RNL pada kanker serviks tipe karsinoma sel skuamosa antar diferensiasi. Kata-kata kunci: kanker serviks tipe karsinoma sel skuamosa; derajat diferens","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78174799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efektivitas Ekstrak Etanol Daun Limau Kuit (Citrus hystrix DC) sebagai Repelen terhadap Nyamuk Aedes aegypti","authors":"Hesty Tri Wira Drana Wasistha, Erida Wydiamala, L. Hayatie","doi":"10.20527/ht.v5i2.6288","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6288","url":null,"abstract":"Abstract: Indonesia is one of the largest countries in the world with a tropical climate. The tropical climate may cause various tropical diseases such as Dengue Hemorrhagic Fever (DHF). The primary vector of DHF is the Aedes aegypti mosquito. The prevention of DHF can be done using repellent (mosquito repellent). Natural repellents are limau kuit leaves (Citrus hystrix DC). Limau kuit leaves contain secondary compounds, such as flavonoids, alkaloids, and tannins that have the potential as repellents. The study's general objective was to test the effectiveness of the ethanol extract of the limau kuit leaves extract against the Aedes aegypti mosquito. This research was a true experimental study with posttest only with control group design, consisting of 4 concentrations of ethanol extract of limau kuit leaves, namely 12.5%, 25%, 50%, 100%, DEET 15% (positive control), and aquadest (negative control) with four replications. Serial consentrations extract of limau kuit leaves, K(-) and K(+), were applied to the backs of mice exposed to mosquitoes for 5 minutes for every minute. The results showed that all concentrations were effective as repellents. The 100% concentration at every minute had no significant difference with the positive control (p>0.05). The conclusions from this research were etanol extact of limau kuit leaves with concentrations of 12.5%,25%,50%, and 100% was effective as a mosquito repellent Aedes aegypti, and ethanol extract of limau kuit leaves with a concentration of 100% was equivalent to 15% DEET. Keywords: Aedes aegypti, limau kuit leaves, repellent Abstrak: Indonesia merupakan salah satu negara terbesar di dunia yang memiliki iklim tropis. Iklim tropis menimbulkan berbagai macam penyakit tropis yang salah satunya dapat disebabkan oleh nyamuk, seperti Demam Berdarah Dengue (DBD). Vektor utama DBD adalah nyamuk Aedes aegypti. Pencegahan penyakit ini dapat dilaksanakan melalui beragam cara atau mekanisme, termasuk penggunaan repelen atau penolak nyamuk. Tanaman yang dapat digunakan sebagai repelen alami adalah daun limau kuit (Citrus hystrix DC). Daun limau kuit mengandung senyawa sekunder, seperti flavonoid, alkaloid, dan tanin yang berpotensi sebagai repelen. Tujuan umum penelitian adalah menguji efektivitas repelen ekstrak etanol daun limau kuit terhadap nyamuk Aedes aegypti. Penelitian ini merupakan penelitian eksperimental murni dengan posttest only with control grup design, terdiri dari 4 konsentrasi ekstrak etanol daun limau kuit yaitu 12,5%,25%,50%,100%, DEET15%(Kontrol positif) dan aquadest(Kontrol negatif) dengan pengulangan sebanyak 4 kali. Serial konsentrasi ekstrak etanol daun limau kuit, K(-) dan K(+) dioleskan ke punggung mencit yang dipaparkan nyamuk selama 5 menit setiap periode pengamatan pada semua menit. Konsentrasi 100% pada semua menit tidak memiliki perbedaan bermakna dengan kontrol positif(p>0,05). Simpulan dari hasil penelitian ini adalah ekstrak etanol daun limau kuit dengan konsentrasi 12,5%,25%,50%,da","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84445848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perbedaan Skor Nasional dan Internasional dalam Mendiagnosis Pasien dengan Apendisitis Akut di RSUD Ulin Banjarmasin","authors":"Ovimillia Anindia Tasya, A. Wibowo, Ida Yuliana, Winardi Budiwinata, M. Mashuri","doi":"10.20527/ht.v5i2.6281","DOIUrl":"https://doi.org/10.20527/ht.v5i2.6281","url":null,"abstract":"Abstract: Appendicitis is a disease caused by a blockage in the appendix. In 2009 it was found that at least 596,132 people in Indonesia had acute appendicitis. The diagnosis of appendicitis can be seen based on clinical manifestations, physical examination, and supporting examinations. Scoring is the fastest tool for predicting the diagnosis of acute appendicitis. This study will show whether there are differences in Alvarado scores, modified Alvarado scores, and Kalesaran scores in diagnosing acute appendicitis patients. With an analytical observational study, 66 samples from purposive sampling were processed through a retrospective cross-sectional approach. The inclusion criteria determined were patients aged 18-65 years and patients with physical examination of fever, epigastric diffuse pain, anorexia, nausea and vomiting, lower right tenderness, loose tenderness, Rovsing Sign, Psoas Sign, cough sign, leukocytosis, and displacement neutrophils to the left. With the exclusion criteria of patients with other infections and patients with incomplete data in the morning report. 44% were patients aged 18-25, and 9% were 56-65 years. 63% experienced by men and 38% by women. The most common manifestation was tenderness in the right lower quadrant while the least was fever with a total of 24 people. Data analysis using logistic regression showed P > 0.05 with the conclusion that there was no significant difference between Alvarado, modified Alvarado, and Kalesaran scores in diagnosing acute appendicitis patients. Keywords: acute appendicitis, Alvarado score, modified Alvarado score, Kalesaran Abstrak: Apendisitis merupakan  penyakit yang disebabkan oleh sumbatan pada apendiks. Pada 2009 didapatkan setidaknya 596.132 orang di Indonesia mengalami apendisitis akut. Diagnosis apendisitis dapat dilihat berdasarkan  manifestasi klinis, pemeriksaan fisik, serta pemeriksaan penunjang. Skoring menjadi alat paling cepat untuk memprediksi diagnosis apendisitis akut. Penelitian ini akan menunjukkan apakah terdapat perbedaan skor Alvarado, skor Alvarado termodifikasi, dan Skor Kalesaran dalam mendiagnosis pasien apendisitis akut. Dengan penelitian observasional analitik, 66 sampel dari purposive sampling diolah melalui pendekatan retrospective cross-sectional. Kriteria inklusi yang ditentukan adalah pasien dengan umur 18-65 tahun dan pasien dengan pemeriksaan fisik demam, nyeri baur epigaster, anoreksia, mual muntah, nyeri tekan kanan bawah, nyeri tekan lepas, Rovsing Sign, Psoas Sign, cough sign, leukositosis, serta perpindahan neutrofil ke kiri. Dengan kriteria eksklusi pasien yang mengalami infeksi lain serta pasien dengan data tidak lengkap pada morning report. 44% merupakan pasien dengan umur 18-25, dan 9% pada 56-65 tahun. 63% dialami oleh laki-laki dan 38% oleh perempuan.manifestasi paling banyak ditemukan adalah nyeri tekan pada kuadran kanan bawah sedangkan paling sedikit adalah demam dengan jumlah 24 orang. Analisis data menggunakan regresi logistik menu","PeriodicalId":77544,"journal":{"name":"Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75370762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}