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A New Range of Chitosan Based Nano-antiviral Agents 基于壳聚糖的新型纳米抗病毒药物
Pub Date : 2021-08-05 DOI: 10.31901/24566306.2021/13.1-2.259
Julio C. Garay-Jimenez
ABSTRACT The current study involves the synthesis of fourteen analogs of oligochitosan and their screening for antiviral potential against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV) and Coxsackie virus. The synthesized oligochitosan analogs were characterized by nuclear magnetic resonance (NMR) and FTIR techniques. HIV-1 p24 ELISA was performed using HIV-1 p24 antigen capture assay in order to estimate the viral infectivity loss. It was observed that sulfated oligochitosan was devoid of antiviral activity as compared to oligochitosan UN102 analog. The rest of UN102 analogs which include N-thiol (UN105), N-glutaryl (UN106), N-Azido (UN111) and N-phthaloyl (UN114) and N-citric analog (UN117) exhibited antiviral activity against HIV. The UN102 also decreased viral infection caused by RSV. In addition, UN102 was found to bind Coxsackie virus, which causes autoimmune myocarditis. The findings were of great interest to proceed for the development of novel antiviral agents.
摘要:本文研究了14种低聚壳聚糖类似物的合成及其对人类免疫缺陷病毒(HIV)、呼吸道合胞病毒(RSV)和柯萨奇病毒的抗病毒潜力筛选。利用核磁共振(NMR)和红外光谱(FTIR)技术对合成的低聚壳聚糖类似物进行了表征。采用HIV-1 p24抗原捕获法进行HIV-1 p24酶联免疫吸附测定,以估计病毒的感染性损失。结果表明,与低聚壳聚糖UN102类似物相比,硫酸化低聚壳聚糖缺乏抗病毒活性。其余的UN102类似物包括n -硫醇(UN105)、n -戊二酰(UN106)、n -叠氮(UN111)、n -邻苯二酰(UN114)和n -柠檬酸类似物(UN117),均表现出抗病毒活性。UN102还能降低RSV引起的病毒感染。此外,还发现UN102与引起自身免疫性心肌炎的柯萨奇病毒结合。研究结果对开发新型抗病毒药物具有重要意义。
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引用次数: 0
Biomass Mass Production and Partitioning in Seedling of Harerghe Coffee Genotypes Under Deficit Irrigation at Jimma, Southwest Ethiopia 埃塞俄比亚西南部Jimma缺灌条件下Harerghe咖啡基因型幼苗生物量产量及分配
Pub Date : 2021-07-15 DOI: 10.11648/J.AJLS.20210904.12
Minda Tadesse
In Ethiopia, the coffee production is highly constrained by drought. To overcome such problem, knowing the behavior of coffee genotype’s biomass accumulation pattern to different parts under contrasting moisture stress is important in selection of drought tolerant genotypes. Therefore, the objectives of the present study were to evaluate and characterize the biomass partitioning patterns of Harerghe coffee genotypes as influenced by deficit irrigation in rain shelter at Jimma agricultural research center. An experiment was conducted in completely randomized block design with three replications, where treatments consisted of three deficit level (40, 80 and 120% of ETc) and six genotypes (H-674/98, H-739/98, H-823/98, H-981/98, H-929/98 and H-857/98). The result showed that the coffee dry-biomass partitioning patterns were significantly varied due deficit irrigation and genotypes as well as their interactions. Overall, the biomass assimilation and allocation were higher for roots (37%) under 40% ETc and finally dropped to 23% under well watered seedlings, the investment made in root at the expense of shoot in drought conditions, enables the plants to extract more water from dipper soil layers, if water is limited in upper soil layers Conversely, the dry matters portioned to leaf were greater (48%) under well watered seedlings and finally dropped to 26% under water stressed conditions. The accumulation of more dry-mater to leaf in well irrigated environment enables the plants to enhance photosynthetic capacity and thereby improve plant growth. Lastly, the study of dry biomass partitioning patterns in different parts of coffee plant is crucial important to decide appropriate watering amount and identifying drought tolerant genotypes for future breeding program under variable climatic conditions.
在埃塞俄比亚,咖啡生产受到干旱的严重限制。为了克服这一问题,了解不同水分胁迫条件下咖啡基因型不同部位生物量积累模式的行为,对选择耐旱基因型具有重要意义。因此,本研究旨在评价和表征吉马农业研究中心雨棚亏缺灌溉对哈尔河咖啡基因型生物量分配格局的影响。试验采用完全随机区组设计,3个重复,处理3个亏缺水平(ETc的40%、80%和120%)和6个基因型(H-674/98、H-739/98、H-823/98、H-981/98、H-929/98和H-857/98)。结果表明,缺灌和基因型及其相互作用使咖啡干生物量分配格局发生显著变化。总体而言,在40% ETc条件下,根系的生物量同化和分配更高(37%),而在水分充足的幼苗条件下,生物量同化和分配最终下降到23%,在干旱条件下,以牺牲茎部为代价的根系投资使植物能够从深层土壤中提取更多的水分,如果上层土壤水分有限,反之,水分充足的幼苗条件下,分配给叶片的干物质更大(48%),在水分胁迫条件下,最终下降到26%。在良好的灌溉环境下,植物向叶片积累更多的干物质,使植物的光合能力增强,从而促进植物生长。最后,研究咖啡树不同部位的干生物量分配规律,对于确定适宜的浇水量和确定耐旱基因型,为未来不同气候条件下的育种计划提供重要依据。
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引用次数: 2
Application Frequency of Beauvaria bassiana Isolates Against Antestia Bugs (Antetiopsis intircata: Pentatomidea, Hemimptera) Management 球孢白僵菌分离株对蚁虫(antitiopsis intirata: Pentatomidea, Hemimptera)防治的应用频率
Pub Date : 2021-06-30 DOI: 10.11648/J.AJLS.20210903.13
B. Abate, Nagasa Dechassa
The production and productivity of coffee is affected by many insect pests and Ethiopian farmers get below 0.636 tons per hectare. Among insect pests Antestia bug is the major coffee insect pest affecting coffee productions. Therefore, the study was carried out to determine the frequency of promised Entomopathogenic fungi isolates against antestia bug. The experiment was done in Jimma Agricultural Research Center, Entomology and Pathology laboratories. Used entomopathogenic fungi isolates were brought from Ambo Agricultural Research Center. Two isolates of Beauvaria bassiana, PPRC-44BC and PPRC-27J isolates applied at 1x108 conidia ml-1 and three times were used for the experiment. Completely randomized design with three replications and probit analysis were used for data analysis by using SAS software version 9.3. PPRC-44BC and PPRC-27J isolates killed all the tested Antestia bugs in exposure time. The isolates applied three times reduced median lethal time by 42.13 and 38.89%, respectively as compared to with their respective one time application. The correlation result also showed that there was strong negative correlation between application frequency of isolates and median lethal times (LT50 and LT90 were r=-0.811 and r=-0.714, respectively). The study indicated that the more frequently applied isolates the shorter the median lethal time. This showed promising result in the microbials based insect pest management methods and need further investigations under field conditions and the effect of these isolates against natural enemies of the pest.
咖啡的产量和生产力受到许多害虫的影响,埃塞俄比亚农民的产量低于每公顷0.636吨。在害虫中,蚁蜂是影响咖啡生产的主要害虫。因此,我们进行了研究,以确定有希望的昆虫病原真菌分离株的频率。实验在吉马岛农业研究中心、昆虫学和病理学实验室进行。从安博农业研究中心分离出昆虫病原真菌。球孢白僵菌分离株PPRC-44BC和PPRC-27J分别在1 × 108分生孢子ml-1上施用3次。采用SAS 9.3版软件进行数据分析,采用3个重复的完全随机设计和概率分析。PPRC-44BC和PPRC-27J分离株在暴露时间内杀死了所有被测的蚁虫。与单次施用相比,三次施用的中位致死时间分别缩短42.13%和38.89%。相关结果还显示,菌株施药频率与中位致死时间呈极显著负相关(LT50和LT90分别为r=-0.811和r=-0.714)。研究表明,施用频率越高,中位致死时间越短。这显示了基于微生物的害虫管理方法的良好结果,需要在野外条件下进一步研究这些分离物对害虫天敌的效果。
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引用次数: 0
Nutritional Status of Primary Schoolgoing Santhal Children of Paschim Medinipur District, West Bengal, India 印度西孟加拉邦Paschim Medinipur区的小学学童营养状况
Pub Date : 2021-06-08 DOI: 10.31901/24566306.2021/13.1-2.260
S. Roy
ABSTRACT Rural tribal children of India are facing difficult growing conditions. It is very important to track the nutritional status of tribal children to understand their current situation. The present study was conducted to understand the nutritional status of Santhal children of Paschim Medinipur in West Bengal, India. The present study is cross-sectional, ex-post-facto research. The study depicts that nearly one-third of the study children are undernourished (26.38% stunted, 37.78% underweight, 25.73% thin). A higher percentage of underweight (41.6%), stunting (29.8%) and thinness (28%) can be observed among boys compared to the girls (33.6%, 22.6%, 23.3% respectively) in this area. The differences in the nutritional status of boys and girls are not statistically significant. The study concludes that Santhal children of this area are facing difficult situations concerning nutritional status, which indirectly indicates compromised health and wellbeing
印度农村部落的孩子们正面临着艰难的成长环境。跟踪部落儿童的营养状况,了解他们的现状是非常重要的。本研究旨在了解印度西孟加拉邦Paschim Medinipur的Santhal儿童的营养状况。目前的研究是横向的,事后的研究。该研究显示,近三分之一的研究儿童营养不良(26.38%发育不良,37.78%体重不足,25.73%消瘦)。该地区男孩体重不足(41.6%)、发育迟缓(29.8%)和消瘦(28%)的比例高于女孩(分别为33.6%、22.6%和23.3%)。男孩和女孩营养状况的差异在统计上并不显著。该研究的结论是,该地区的Santhal儿童在营养状况方面面临困难,这间接表明健康和福祉受到损害
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引用次数: 0
Study on Maternal Health Care Services in the Eastern Indian States 印度东部各邦孕产妇保健服务研究
Pub Date : 2021-06-03 DOI: 10.31901/24566306.2021/13.1-2.258
S. Banerjee
ABSTRACT The aim of the present study was to investigate the maternal healthcare services in Eastern Indian States (West Bengal, Odisha, Jharkhand, Bihar). The present study also tried to understand the effect of socio-economic and demographic factors in the utilization of maternal health care services in the above mentioned states of India, using NFHS-4 data. The present study considered only those women who conceived baby within last five years. All the study women were married and the age range was 15-49 years. Total sample size consisted of 170995 of ever married women. For statistical analysis, Pearson Chi-squre test and Binary logistic regression were performed. The present study revealed that statistically significant difference in utilization of maternal health care services were present among women of different Eastern Indian states.The present study also depicted that residential pattern, caste, religion, respondent’s occupation, respondent’s age, respondent’s educational attainments, Wealth Index had significant association with maternal health care services
本研究的目的是调查印度东部各州(西孟加拉邦、奥里萨邦、贾坎德邦、比哈尔邦)的孕产妇保健服务。本研究还利用NFHS-4数据,试图了解社会经济和人口因素对印度上述各邦孕产妇保健服务利用情况的影响。本研究只考虑了最近五年内怀孕的妇女。所有参与研究的女性都已婚,年龄在15-49岁之间。总样本量包括170995名已婚妇女。统计分析采用Pearson χ 2检验和二元logistic回归。本研究表明,印度东部不同邦的妇女在利用孕产妇保健服务方面存在统计学上的显著差异。居住模式、种姓、宗教、被调查者职业、年龄、受教育程度、财富指数与孕产妇保健服务显著相关
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引用次数: 0
Assessing the Prevalence of Malaria, in the Case of Sigmo Health Center, Sigmo Woreda, Jimma Zone, South West Ethiopia 评估疟疾流行情况,以埃塞俄比亚西南部吉马区的西格莫卫生中心为例
Pub Date : 2021-05-14 DOI: 10.11648/J.AJLS.20210902.13
Guta waktole Weyesa
Despite considerable efforts made throughout the century to eradicate or control malaria it is still the most prevalent and most devastating disease in the global tropics. The disease has a negative effect on the economic growth and perpetuates vicious cycles of poverty especially in the developing parts of the world. It costs Africa US$10 – 12 billion every year in lost domestic product even though it could be controlled for a fraction of that sum. In Africa, the malaria causes about 20% of cerebral conditions leading to coma and death. One important strategy to prevent malaria infection is the use of insecticide treated mosquito net. Many researches were done in Ethiopia on the prevalence of malaria. Even though many researches were done on the prevalence of malaria in other place of the country, no any recent study conducted in Sigmo Health centre. Since knowing the prevalence of malaria is very important and the prevalence of malaria in Sigmo Health centre is yet not well known the investigator was interested to do research on this area to fill the knowledge gap. The main objective of this study is to assess the prevalence of malaria from 2000 to 2009, in the case of Sigmo health center, Jimma zone, South-west Ethiopia. The study was conducted in Sigmo health centre, Sigmo woreda, located in Jimma zone from Dec 2016 to August 2017. The source of population was all patients admitted at Sigmo health center from 2000-2009. Secondary data collected from from the health centre was used as a source of data. After collected data cleared and checked for their completeness, the data were analyzed by using a scientific calculator. Accordingly compared to other areas, in the current study site, the prevalence of malaria was low (3%) throughout the years (2000-2009). The most prevalent parasite in the study site was plasmodium vivax (76%) and female were the most affected by malaria. Thus, the declining pattern of malaria infection in the study area could be evidence for intense intervention strategies undertaking in the study area.
尽管整个世纪为根除或控制疟疾作出了相当大的努力,但它仍然是全球热带地区最普遍和最具破坏性的疾病。这种疾病对经济增长产生不利影响,使贫穷的恶性循环长期存在,特别是在世界发展中地区。它使非洲每年损失100亿至120亿美元的国内生产总值,尽管它可以控制在这个数字的一小部分。在非洲,疟疾导致约20%的脑部疾病导致昏迷和死亡。预防疟疾感染的一项重要战略是使用经杀虫剂处理的蚊帐。在埃塞俄比亚进行了许多关于疟疾流行的研究。尽管对该国其他地方的疟疾流行情况进行了许多研究,但最近在Sigmo保健中心没有进行任何研究。由于了解疟疾的流行情况非常重要,而Sigmo卫生中心的疟疾流行情况尚不为人所知,因此调查人员有兴趣对这一领域进行研究,以填补知识空白。本研究的主要目的是评估2000年至2009年埃塞俄比亚西南部吉马地区Sigmo卫生中心的疟疾流行情况。该研究于2016年12月至2017年8月在位于Jimma区的Sigmo woreda的Sigmo卫生中心进行。人口来源为2000-2009年在Sigmo卫生中心住院的所有患者。从保健中心收集的二手数据被用作数据来源。收集到的数据进行清理和完整性检查后,使用科学计算器对数据进行分析。因此,与其他地区相比,在目前的研究地点,疟疾的流行率在整个年份(2000-2009年)都很低(3%)。研究地点最流行的寄生虫是间日疟原虫(76%),女性受疟疾影响最大。因此,研究区疟疾感染的下降模式可能是研究区实施强化干预策略的证据。
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引用次数: 0
On farm Phenotypic Characterization of Indigenous Goat Breeds within Their Production System in Ancher and Gemechis Districts, West Hararghe Zone, Eastern Ethiopia 埃塞俄比亚东部西哈拉尔河地区Ancher和Gemechis地区本地山羊品种在其生产系统中的农场表型特征
Pub Date : 2021-05-08 DOI: 10.11648/J.AJLS.20210902.12
M. Yousuf, T. Getachew, E. Bayou
This study was conducted to study the morphological characteristics of indigenous goats breed under farmer’s management condition in Ancher and Gemechis districts, West Hararghe Zone, Eastern Ethiopia. The most frequently observed coat color pattern of goat was (60.8%) plain, (9.1%) spotted and (30.1%) were patchy coat color and coat color type in the study area was brown (36.8%) followed by white (24.7%). Heart girth had consistently the highest correlation coefficient (0.80), (0.76), (0.90) with body weight of intact male, female and castrated male goat respectively in both study districts. The mean of body weight, body length, chest girth, wither height, chest width, pelvic width, face length, horn length, rump length, ear length intact male are 38.1±0.7, 65.2±0.63, 74.0±0.70, 69.0±0.48, 15.0±0.12, 15.±0.14, 19.8±0.18, 16.0±0.56, 16.0±0.23, 14.4±0.14, respectively. The corresponding values for the female goat were 32.0±0.22, 62.0±0.20, 70.0±0.22, 64.7±0.15, 14.2±0.04, 13.8±0.04, 19.0±0.06, 12.0±0.23, 15.0±0.07, 14.1±0.04, respectively. The mean of body weight, body length, chest girth, wither height, chest width, pelvic width, face length, horn length, rump length, ear length castrated male are 44.4±0.42, 69.6±0.37, 78.9±0.42, 72.9±0.29, 15.1±0.07, 16.4±0.08, 20.5±0.12, 18.1±0.44, 15.8±0.14, 14.7±0.08, respectively. The body weight of castrated male goat was higher than the intact male and female goat in both districts. As conclusion castrated male goat has potential for improving income and to increase economy of smallholder farmers in the study areas as well as in the surrounding areas.
本研究对埃塞俄比亚东部西哈拉尔河地区Ancher和Gemechis地区农民经营条件下本地山羊的形态特征进行了研究。研究区山羊最常见的被毛色为素色(60.8%)、斑点色(9.1%)和斑点色(30.1%),被毛色类型以棕色(36.8%)次之,白色(24.7%)。两个研究区完整公山羊、母山羊和去势公山羊的胸围与体重的相关系数分别最高(0.80)、(0.76)和(0.90)。完整雄鼠体重、体长、胸围、肩高、胸宽、盆宽、脸长、角长、臀长、耳长平均分别为38.1±0.7、65.2±0.63、74.0±0.70、69.0±0.48、15.0±0.12、15±0.14、19.8±0.18、16.0±0.56、16.0±0.23、14.4±0.14。母山羊的相应值分别为32.0±0.22、62.0±0.20、70.0±0.22、64.7±0.15、14.2±0.04、13.8±0.04、19.0±0.06、12.0±0.23、15.0±0.07、14.1±0.04。去势雄体质量、体长、胸围、枯高、胸宽、盆宽、脸长、角长、臀长、耳长平均分别为44.4±0.42、69.6±0.37、78.9±0.42、72.9±0.29、15.1±0.07、16.4±0.08、20.5±0.12、18.1±0.44、15.8±0.14、14.7±0.08。两区阉割公山羊体重均高于未阉割公山羊和未阉割母山羊。综上所述,去势公山羊具有提高研究区及周边地区小农收入和经济增长的潜力。
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引用次数: 0
COVID-19: Third Wave Feared as Cases Soar and Precautionary Measures COVID-19:病例激增和预防措施引发第三波恐慌
Pub Date : 2021-04-29 DOI: 10.11648/J.AJLS.20210902.11
Hina Afzal Sajid, Ahmad Ali, Y. Khan, A. Rabbani, K. Hussain, Nayab Arshad, Rabia Khan
A novel coronavirus has become a major health issue worldwide, initially founded in Wuhan city, province of china, in the end of December 2019. Now it has widely spread across 215 countries. On 30th of January 2020, World Health Organization (WHO) declared sixth public health emergency of international concern (PHEIC) to be COVID-19 outbreak as pandemic. Easing up on lockdowns and mandatory precautionary strategies has led to a sharp increment in mortalities across the world. Fear of third wave in different countries, World health organizations (WHO) and governments have to give the Standard Operation Protocols SOPs for coming wave of pandemic. Countries have not yet achieved the complete control of the spread of COVID-19 and third wave of infection is already beginning throughout the world. Many experts are predicting that COVID-19 may extend its stay and countries need to continue exercise stringent quarantine, lockdown, social-distancing and use of face masks as well as personal and environmental hygiene is very important to evade the risk of this virus. Countries will need strict actions like smart lockdown, restrict the gathering of peoples, self-isolation, social-distancing, health measures including COVID-19 vaccines, better adherence towards quarantine, responsible mass and social media, and implement mitigating measures to combat COVID-19.
一种新型冠状病毒于2019年12月底在中国武汉市首次出现,已成为全球重大健康问题。现在它已经在215个国家广泛传播。2020年1月30日,世界卫生组织(世卫组织)宣布第六次国际关注的突发公共卫生事件(PHEIC)为COVID-19疫情为大流行。放松封锁和强制性预防战略导致世界各地的死亡率急剧上升。由于担心第三波疫情在不同国家蔓延,世界卫生组织(WHO)和各国政府不得不制定标准操作规程(sop)来应对即将到来的大流行浪潮。各国尚未完全控制COVID-19的传播,世界各地已经开始出现第三波感染。许多专家预测,COVID-19可能会延长其停留时间,各国需要继续实行严格的隔离、封锁、社交距离、使用口罩以及个人和环境卫生,这对避免这种病毒的风险非常重要。各国将需要采取严格的行动,如智能封锁、限制人群聚集、自我隔离、保持社交距离、包括COVID-19疫苗在内的卫生措施、更好地遵守隔离、负责任的大众和社交媒体,以及实施缓解措施来抗击COVID-19。
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引用次数: 1
Role of Radiologic Computed Tomography in Evaluating Coronavirus (COVID-19) Patients 放射计算机断层扫描在评估冠状病毒(COVID-19)患者中的作用
Pub Date : 2021-04-14 DOI: 10.32861/AJLS.72.39.44
M. Aldosh
Objective: Coronavirus (Covid 19) is a dangerous viral disease that principally targets the respiratory system of human beings. The main objective of this study is to evaluate the significant effects resulting from Covid19 using radiologic CT scanning technology. Methods: The recent study was conducted in order to evaluate covid19 among the local public. The sample size for this study consisted of two hundred and thirty (230) patients diagnosed with coronavirus and underwent a chest computed tomography scan. The study was conducted at Najran city, between the period from September to December 2020. Results: The results showed that it is possible to diagnose the complications of coronavirus that affects the respiratory tract in an accurate manner using chest CT imaging and the main results revealed that coronavirus COVID-19 affected all, but males more than female. (50-60) Age group was the big distribution while acute respiratory failure is the most common clinical etiology. The CT scan findings revealed that bilateral pneumonia was the common complication with a high incidence rate of 32% percent and blood coagulation achieved 5% percent as the minimum distribution result. Conclusion: The sensitivity of the CT scans in assessing COVID-19 was significantly high, it has the efficiency to assess complications of COVID-19 in an accurate manner, and therefore it has been proposed to use CT scan as a complementary method in covid-19 diagnosis. More studies on coronavirus disease were recommended by the author.
目的:冠状病毒(Covid - 19)是一种主要以人类呼吸系统为靶点的危险病毒性疾病。本研究的主要目的是利用放射学CT扫描技术评估covid - 19带来的显著影响。方法:对当地公众进行新冠肺炎疫情评估。这项研究的样本量包括230名被诊断患有冠状病毒并接受胸部计算机断层扫描的患者。该研究于2020年9月至12月期间在纳季兰市进行。结果:胸部CT成像可以准确诊断冠状病毒感染呼吸道的并发症,主要结果显示冠状病毒感染全部发生,但男性多于女性。(50 ~ 60岁)年龄层分布大,急性呼吸衰竭是最常见的临床病因。CT扫描结果显示双侧肺炎为常见并发症,发生率高达32%,凝血率最低分布结果为5%。结论:CT扫描评估COVID-19的敏感性明显较高,能够准确评估COVID-19的并发症,因此建议将CT扫描作为COVID-19诊断的补充方法。作者建议对冠状病毒进行更多的研究。
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引用次数: 0
해양 환경의 미세 플라스틱과 인간의 건강에 미치는 영향 海洋环境中的微细塑料和对人类健康的影响
Pub Date : 2021-04-01 DOI: 10.5352/JLS.2021.31.4.442
박지아, 강현본, 최윤식
미세 플라스틱은 입자의 크기가 5 mm 이하인 플라스틱 조각을 말하며 미세 플라스틱의 오염은 해양 생태계와 인간의 건강과 관련되어 전 세계적인 관심사이다. 광범위하게 오염되어 있는 관계로, 미세 플라스틱은 물고기, 담치, 굴, 조개, 가리비와 같이 다양한 동물에 섭취되어 체내에 축적된다. 게다가, 섭취된 미세 플라스틱은 소장, 간, 신장 그리고 심지어 뇌에서도 높은 농도로 관찰된다. 해산물은 인간에게 있어 주요 단백질 공급원 중 하나이므로, 해산물의 소비는 인간이 미세 플라스틱에 노출되는 경로가 될 수 있다. 많은 근거들은 설치류에서 미세 플라스틱의 반복적인 경구 투여가 생식, 심장, 소화기, 내분비 그리고 심지어 신경계에서 병리적, 기능적 변화를 유도함을 가리킨다. 더욱이, 임신기와 수유기 동안 모체가 미세 플라스틱에 노출되면 새끼에서 대사의 항상성에 변화가 일어난다. 해산물은 세계적으로 3억 1천만 명 이상의 사람들에게 20% 이상의 단백질 공급원이라는 사실을 고려할 때, 미세 플라스틱은 인간의 몸에 축적되어 생리적 기능에 장애를 유발할 수 있다고 가정하는 것이 타당하다. 본 리뷰에서 우리는 해양에서 미세 플라스틱 오염의 현재 실태와 해양 동물 및 설치류에서 미세 플라스틱의 축적과 독성, 그리고 인간에게의 노출과 인간 건강에 미치는 잠재적인 영향에 대해 요약하였다.
微塑料是指粒子大小在5毫米以下的塑料碎片,微塑料的污染与海洋生态界和人类健康有关,是全世界都在关注的问题。由于受到广泛污染,微细塑料被鱼、淡水鱼、牡蛎、蛤蜊、扇贝等多种动物摄取并积累在体内。此外,摄取的微细塑料在小肠、肝脏、肾脏甚至大脑中都有很高的浓度。海产品是人类的主要蛋白质来源之一,因此海产品的消费可以成为人类接触微细塑料的途径。许多根据是,在啮齿类动物中,反复口服微细塑料会导致生殖、心脏、消化器官、内分泌,甚至神经系统的病理和功能变化。而且,在怀孕期和哺乳期内,如果母体暴露在微细塑料中,幼仔的代谢常时性就会发生变化。考虑到海产品对世界上3亿1千万以上的人来说是20%以上的蛋白质供给源这一事实,我们应该假设微细塑料会在人体中积累,引发生理功能障碍。在本评论中,我们总结了海洋中微塑料污染的现状,海洋动物及啮齿类动物中微塑料的积累和毒性,以及对人类暴露和人类健康的潜在影响。
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