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Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR最新文献

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[Basic studies of ultrasound surgery. VIII. Experimental animal studies of power ultrasound surgery of the swine pancreas]. 超声手术的基础研究。8猪胰腺功率超声手术的实验动物研究[j]。
K Nowotny, G Fritzsch, J Füssel, J Vetter, W Wehner, P Ludwig, R Kühnert, R Morgenstern, P Daniel

The technique of the power ultrasound was tested in vitro and in vivo in 20 porcine pancreas. Simultaneous temperature measurements and laboratory tests do not produce any restriction. Enzymatic disorders were provable adequate to the clinical course. The ultrasonic effect guarantees a nearly riskless dissection in the layer. Joining processes, by adding Ligament-FIMOMED, produced a waterproof occlusion of parenchymal wounds. The cross-section of the pancreas with the pancreatic duct was sealed sufficiently. Also the jointed pancreato-jejunostomy remained sufficient. The reaction of the pancreatic parenchyma to the power ultrasound was small. A scarred metaplasia evolved immediately at the adhesive as a chronic atrophic interstitial pancreatitis. Only in case of occlusion of the pancreatic duct this alteration comprehended the whole pancreas.

在体外和体内对20只猪胰腺进行了功率超声技术的试验。同时进行温度测量和实验室测试不会产生任何限制。经证实,酶紊乱足以适应临床病程。超声效应保证了层内几乎无风险的解剖。连接过程,通过添加韧带- fimomed,产生了一个防水闭塞的实质伤口。胰腺与胰管的横切面密封充分。联合胰空肠吻合术仍然足够。胰腺实质对功率超声的反应较小。在黏着处立即发生瘢痕化,表现为慢性萎缩性间质性胰腺炎。只有在胰管闭塞的情况下,这种改变才包括整个胰腺。
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引用次数: 0
Comparison of respiratory and cardiovascular effects of halothane, isoflurane, and enflurane delivered via the Jackson-Rees breathing system in rats. New anaesthesia model for small animal surgery. Jackson-Rees呼吸系统给药氟烷、异氟烷和安氟烷对大鼠呼吸和心血管影响的比较小动物手术麻醉新模型。
E Dárdai, J E Heavner

We studied the respiratory (R) and cardiovascular (CV) effects of 1.25 MAC halothane (H), isoflurane (I) and enflurane (E) in oxygen, delivered by the Jackson-Rees breathing system in 5 normothermic rats. Mean arterial pressure (MAP), heart rate (HR) were depressed after 30 minutes than stabilized after 2 hours anaesthesia regardless of the inhalational agent. Respiratory rate (RR) slowed down markedly unter I and E anaesthesia. Significant R depression was developed (PCO2 53.5 +/- 2.44 Torr) under E. Stabil metabolic condition was maintained. The R and CV changes caused by H and I were far less than changes produced by E. H or I is preferable to E for small animal anaesthesia with spontaneous breathing. Maintenance of constant temperature minimizes the CV and R disturbances.

研究了Jackson-Rees呼吸系统给氧1.25 MAC氟烷(H)、异氟烷(I)和安氟烷(E)对5只常温大鼠呼吸(R)和心血管(CV)的影响。麻醉30分钟后平均动脉压(MAP)、心率(HR)下降,麻醉2小时后稳定。I、E麻醉下呼吸频率(RR)明显减慢。e组R显著降低(PCO2 53.5 +/- 2.44 Torr),代谢状态保持稳定。H和I引起的R和CV变化远小于E引起的变化。对于自主呼吸的小动物麻醉,H或I优于E。保持恒温可以使CV和R的干扰降到最低。
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引用次数: 0
[Ultrasound attenuation as a function of frequency in formalin fixed testicular tissue]. [超声衰减在福尔马林固定睾丸组织中的频率函数]。
H Heynemann, K P Richter, J Haerting, H J Holzhausen, J Baumann, K Jenderka, R Millner, B Langkopf

Measurements of the ultrasound attenuation were carried out in 10 normal testes and 20 pathologically changed testicular tissue biopsies in vitro after formalin fixation. The ultrasound attenuation as function of the frequency was recorded ultrasound-spectroscopically about the complete frequency spectrum of the ultrasound-broad range transformer (3-8 MHz). The frequency dependence of the attenuation behaviour differed in the 10 normal testes from the 20 pathologically changed biopsies by smaller values of the ultrasound attenuation coefficient a (linear regression analysis). The ultrasound attenuation in a characteristic measuring point allows the differentiation between normal and pathologically changed testicular tissue. The following comparison with the histologic evidences showed the correspondence of the results.

对10例正常睾丸和20例病理改变的睾丸组织进行福尔马林固定后体外超声衰减测量。超声谱法记录了超声宽量程变压器全频谱(3 ~ 8 MHz)的超声衰减随频率的变化。衰减行为的频率依赖性在10个正常睾丸和20个病理改变活检中不同,超声衰减系数a值较小(线性回归分析)。超声衰减在一个特征测量点允许区分正常和病理改变睾丸组织。随后与组织学证据比较,结果一致。
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引用次数: 0
[The production of eluates for testing acute cytotoxicity by a new method]. [用新方法制备急性细胞毒性试验洗脱液]。
T Schubert, S Hegner, J Bergner

In vitro tests of new biomaterials require internationally and nationally eluates increasingly. Only the extracted substances become effective in the cells in that way. The material surface has the greatest influence on the quantity of the released substances by elution. The surface of diverse undefined mixture quantities is definable exactly by means of a gas adsorption method (BET method). The influence of the secondary technologies was tested by the atom adsorption spectrometry. The Jena bioglass ceramics could be estimated successfully by this method.

新型生物材料的体外试验越来越需要国际和国内的认可。只有提取出来的物质才能以这种方式在细胞中发挥作用。材料表面对洗脱释放物质的量影响最大。用气体吸附法(BET法)精确地定义了各种未定义混合量的表面。采用原子吸附光谱法对二次工艺的影响进行了考察。该方法可以成功地对耶拿生物玻璃陶瓷进行预估。
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引用次数: 0
[Islands of Langerhans of cattle--potential donor tissue for clinical islet transplantation?]. [牛朗格汉斯岛-临床胰岛移植的潜在供体组织?]。
B J Hering, D Romann, A Clarius, M Brendel, R G Bretzel, K Federlin

A standard method for bovine islet isolation has been developed. The mean islet yield per gram pancreas obtained from the last twelve consecutive glands was 2,098 +/- 292 representing an insulin recovery of 36.1 +/- 6.5%. The static incubation of freshly isolated bovine islets in the presence of glucose resulted in a less distinct increase of insulin secretion than in the presence of free fatty acids. Nevertheless, xenotransplantation of bovine islets to immunosuppressed C57BL6J mice did reverse streptozotocin-induced diabetes for 2 to 6 days.

建立了牛胰岛分离的标准方法。从最后12个连续腺体中获得的每克胰腺平均胰岛产量为2098 +/- 292,代表胰岛素回收率为36.1 +/- 6.5%。新鲜分离的牛胰岛在葡萄糖的存在下的静态孵育导致胰岛素分泌的增加不如在游离脂肪酸的存在下明显。然而,将牛胰岛移植到免疫抑制的C57BL6J小鼠身上,可以逆转链脲佐菌素诱导的糖尿病2 - 6天。
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引用次数: 0
[The effect of hydrocortisone and dopamine on the activity of some lysosomal liver enzymes in experimental endotoxic shock]. [氢化可的松和多巴胺对实验性内源性休克中溶酶体肝酶活性的影响]。
L Trochimowicz, Z Puchalski, J Barczyk, J R Ladny

The influence of hydrocortisone and dopamine to the course of the organic functional changes and the activity of same lysosomal hepatic enzymes were tested in 30 dogs in endotoxic shock. A continuous lowering of the blood pressure and the central venous pressure were observed in the non-treated group. The hemodynamic impairments turned out in the treated groups in a less acute course. The coupled treatment with hydrocortisone and dopamine in the experimental endotoxic shock seems to reduce the activity of the lysosomal enzymes in the liver and in the peripheral blood.

采用内源性休克30只狗,测定了氢化可的松和多巴胺对肝组织有机功能变化过程和同一溶酶体肝酶活性的影响。未治疗组血压和中心静脉压持续下降。治疗组出现血流动力学损伤的急性病程较轻。氢化可的松和多巴胺联用治疗实验性内源性休克似乎可以降低肝脏和外周血中溶酶体酶的活性。
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引用次数: 0
[The effect of the alpha1-receptor blocker prazosin on the microcirculation in the terminal ileum of rabbits]. [α 1受体阻滞剂哌唑嗪对家兔回肠末端微循环的影响]。
B Luther, C Lehmann, A Lewerenz

The effect of the specific alpha1-blocker prazosin (Adversuten) on the microcirculation in the region of the terminal ileum was examined on 10 rabbits. Before and after injection of prazosin into the superior mesenteric artery an isotope-clearance of a 133Xe-solution, applied into the intestinal wall, was performed. Because of the systemic blood pressure decreasing effect of prazosin the circulation of the examined part of the intestine was reduced in spite of the intended vasodilation of the intestinal vessels. The therapeutic applicability of alpha-blockers for intestinal diseases of vascular genesis remains questionable.

用10只家兔观察了特异性α 1受体阻滞剂吡唑嗪对回肠末端微循环的影响。将吡唑嗪注入肠系膜上动脉前后,应用于肠壁的133xe溶液进行同位素清除。由于哌唑嗪降低全身血压的作用,被检查部分的肠道循环减少,尽管预期的肠道血管扩张。α受体阻滞剂对血管源性肠道疾病的治疗适用性仍有疑问。
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引用次数: 0
[Videodensitometry analysis of stomach wall motility--presentation of a new method]. 胃壁运动的视频密度分析——一种新方法的介绍。
M Weissbrodt, I Raue, H Pankau, A Keller, T Baehring, U Schenker

The videodensitometry is a suitable method for recording the gastric wall motility. It provides biosignals amenable by computer. There are no special demands to any organic form or kind of contraction. The asymmetry of the stomach makes no difference, therefore. The hitherto usual manometry will not be superseded. Both methods complete themselves in an ingenious manner. The radiation exposure by videodensitometry can be diminished by modifying the system for image causation.

视频密度仪是记录胃壁运动的一种较好的方法。它提供可由计算机控制的生物信号。对任何有机形式或某种形式的收缩都没有特殊的要求。因此,胃的不对称并没有什么区别。迄今为止常用的测压法不会被取代。这两种方法都以一种巧妙的方式完成自己。通过修改成像原因系统,可以减少视频密度测量的辐射暴露。
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引用次数: 0
Isolated acinar cells from rat pancreas in pathogenic studies on acute pancreatitis. 大鼠胰腺分离腺泡细胞在急性胰腺炎发病研究中的应用。
G Letko, B Falkenberg, R Matthias

In the pathogenesis of acute pancreatitis the events and mechanisms increasing the digestibility of the acinar cells are widely unknown. To study these processes at cellular level, isolated exocrine cells from rat pancreas were utilized as experimental tool. The investigations revealed that extracellularly acting noxae seem to be of less importance to triggering autodigestion. The plasma membrane of the acinar cells was relatively resistant to extracellular trypsin, while anoxia or uncoupling of oxidative phosphorylation obviously reduced the survival of these cells. Combined action of small amounts of trypsin and partial uncoupling resulted in a potentiated cell destruction. The findings presented stress the importance of a well-functioning energy metabolism for the protective potential of acinar cells to further harmful conditions.

在急性胰腺炎的发病机制中,增加腺泡细胞消化率的事件和机制尚不清楚。为了在细胞水平上研究这些过程,以大鼠胰腺外分泌细胞为实验工具。调查显示,细胞外作用的酶似乎是不太重要的触发自身消化。腺泡细胞的质膜对细胞外胰蛋白酶具有相对的抗性,而缺氧或氧化磷酸化解偶联明显降低了这些细胞的存活率。少量胰蛋白酶和部分解偶联的联合作用导致细胞破坏增强。这些发现强调了一个功能良好的能量代谢对腺泡细胞进一步有害条件的保护潜力的重要性。
{"title":"Isolated acinar cells from rat pancreas in pathogenic studies on acute pancreatitis.","authors":"G Letko,&nbsp;B Falkenberg,&nbsp;R Matthias","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the pathogenesis of acute pancreatitis the events and mechanisms increasing the digestibility of the acinar cells are widely unknown. To study these processes at cellular level, isolated exocrine cells from rat pancreas were utilized as experimental tool. The investigations revealed that extracellularly acting noxae seem to be of less importance to triggering autodigestion. The plasma membrane of the acinar cells was relatively resistant to extracellular trypsin, while anoxia or uncoupling of oxidative phosphorylation obviously reduced the survival of these cells. Combined action of small amounts of trypsin and partial uncoupling resulted in a potentiated cell destruction. The findings presented stress the importance of a well-functioning energy metabolism for the protective potential of acinar cells to further harmful conditions.</p>","PeriodicalId":77647,"journal":{"name":"Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR","volume":"22 4","pages":"197-203"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13919669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinico-experimental studies of the effect of the form of anesthesia on the postoperative small intestinal absorption]. 麻醉形式对术后小肠吸收影响的临床-实验研究。
R Weiner, E Bernhard

The behaviour of the small bowel absorption in the immediate postoperative phase after cholecystectomy was tested in 20 patients by means of the modified D-xylose-test. Either the conventional insufflation anesthesia with halothane or the neuroleptic analgesia was used in 10 patients in each case. Characteristic changes of the small bowel absorption were provable after the operation. The postoperative restriction of the absorption was not changed statistically significantly in dependence on the different anesthesia methods. An absorption without restriction exists in both groups at the beginning of the 3rd post-operative day.

采用改良d -木糖试验对20例胆囊切除术后小肠吸收行为进行了检测。10例患者均采用氟烷雾化麻醉或镇静镇痛。术后小肠吸收发生特征性变化。不同麻醉方式对术后吸收限制的影响无统计学意义。两组患者术后第3天开始均出现无限制吸收。
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引用次数: 0
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Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR
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