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Novel sporadic c.2687G>T (p.Gly896Val) CYLD mutation in multiple trichoepitheliomas c.2687G>T (p.Gly896Val) CYLD在多发毛上皮瘤中的突变
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501282
Ahmet Uğur Atılan, Niyazi Cetin
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引用次数: 0
Comment on “The relationship of FricTest® responses with an urticaria activity score, urticaria control test and quality of life scales in patients with symptomatic dermographism” 对“症状性皮肤统计学患者的FricTest®反应与荨麻疹活动评分、荨麻疹控制测试和生活质量量表的关系”的评论
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501285
Prajnasini Satapathy , Rachana Mehta , Ranjana Sah
{"title":"Comment on “The relationship of FricTest® responses with an urticaria activity score, urticaria control test and quality of life scales in patients with symptomatic dermographism”","authors":"Prajnasini Satapathy , Rachana Mehta , Ranjana Sah","doi":"10.1016/j.abd.2025.501285","DOIUrl":"10.1016/j.abd.2025.501285","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 1","pages":"Article 501285"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the genetic and serum expression of LL-37 Antimicrobial Peptide in pemphigus vulgaris and pemphigus foliaceus patients 寻常型天疱疮和叶状天疱疮患者LL-37抗菌肽基因及血清表达的比较
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501262
Fatma Dhaffouli , Nesrine Elloumi , Khadija Sellami , Emna Bahloul , Safa Tahri , Hamida Turki , Hend Hachicha , Olfa Abida
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引用次数: 0
Association of oncogene mutations with clinical and histopathological characteristics in patients with metastatic melanoma 癌基因突变与转移性黑色素瘤患者临床和组织病理学特征的关系
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501260
Julia Amaral Quintiliano , Adauto Ferreira Nunes , Luiza Pinheiro-Hubinger-Stauffer
{"title":"Association of oncogene mutations with clinical and histopathological characteristics in patients with metastatic melanoma","authors":"Julia Amaral Quintiliano , Adauto Ferreira Nunes , Luiza Pinheiro-Hubinger-Stauffer","doi":"10.1016/j.abd.2025.501260","DOIUrl":"10.1016/j.abd.2025.501260","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 1","pages":"Article 501260"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequency of HLA class I and II in an admixed Brazilian population with psoriasis 巴西牛皮癣混合人群HLA I型和II型的频率
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501258
Ana Luisa Sampaio , Bruna Romana-Souza , Haizza Monteiro , Jeane de Souza Nogueira , Danielle Angst Secco , Gilson Costa dos Cantos Jr. , Andrea Monte-Alto-Costa , Flavia Cassia , Sueli Carneiro , Luna Azulay-Abulafia , Luis Cristóvão Porto

Background

Psoriasis is a chronic, immune-mediated disease with a significant genetic component. The HLA-C*06:02 allele is one of the most strongly associated with the disease, particularly influencing early onset and severity. There are few current data on genetics in a Brazilian population with psoriasis.

Objective

This study aimed to investigate the genetic associations between human leucocyte antigen (HLA) alleles and psoriasis in a Brazilian admixed population.

Methods

The authors conducted HLA class I and II genotyping in 144 patients with psoriasis and compared the results with those of 720 controls. Additionally, the authors calculated the Psoriasis Area and Severity Index (PASI) and recorded whether the patient had current or previous systemic treatment for psoriasis and the age of disease onset.

Results

HLA-B*13:02g, B*15:01g, B*37:01g, B*38:01g, B*57:01g, B*57:02g, B*13:02g, C*01:02g, C*06:02g, C*12:03g, C*18:01g, DRB1*01:02g, DRB1*04:08g and DPB1*04:01g alleles were associated with an increased risk of psoriasis (after the Bonferroni correction factor, only the HLA-C*06:02 remained significant). And HLA-DRB1*15:03g conferred protection against psoriasis after Bonferroni correction. Alleles significantly associated with PASI score < 10 were A*34:02g (p = 0.037) and B*50:01g (p = 0.037), while the allele related to PASI > 10 was DRB1*01:01g (p = 0.049). When comparing the age of disease onset, the following alleles were significantly associated with early onset psoriasis (before 30 years of age): B*44:03g (p = 0.010) and C*07:02g (p = 0.022).

Study limitations

The sample size was small compared with other international publications, and the subgroup of patients with mild disease was less represented; however, the combination of analytical approaches (univariate tests, PCA, and correction for multiple comparisons) reinforces the robustness of the work.

Conclusion

The present findings highlight the genetic complexity of psoriasis in a diverse population and suggest that it may not be directly linked to specific genetic factors. Further research is required to explore the environmental and genetic interactions that contribute to psoriasis pathogenesis.
背景银屑病是一种慢性、免疫介导的疾病，具有重要的遗传成分。HLA-C*06:02等位基因是与该疾病最密切相关的等位基因之一，尤其影响早期发病和严重程度。目前关于巴西牛皮癣患者的遗传学数据很少。目的探讨巴西人白细胞抗原（HLA）等位基因与牛皮癣的遗传关系。方法对144例银屑病患者进行HLAⅰ类和ⅱ类基因分型，并与720例对照组进行比较。此外，作者计算了银屑病面积和严重程度指数（PASI），并记录了患者目前或以前是否接受过银屑病的全身治疗以及发病年龄。结果shla -B*13:02g、B*15:01g、B*37:01g、B*38:01g、B*57:01g、B*57:02g、B*13:02g、C*01:02g、C*06:02g、C*12:03g、C*18:01g、DRB1*01:02g、DRB1*04:08g和DPB1*04:01g等位基因与银屑病发病风险增加相关（经Bonferroni校正因子后，只有HLA-C*06:02基因仍显著）。HLA-DRB1*15:03g对Bonferroni矫正后的牛皮癣具有保护作用。与PASI得分<； 10显著相关的等位基因为A*34:02g （p = 0.037）和B*50:01g (p = 0.037)，与PASI得分 >； 10相关的等位基因为DRB1*01:01g （p = 0.049）。在比较发病年龄时，以下等位基因与早发性银屑病（30岁前）显著相关：B*44:03g （p = 0.010）和C*07:02g （p = 0.022）。研究局限性：与其他国际出版物相比，样本量较小，并且轻症患者亚组的代表性较低；然而，分析方法的结合（单变量检验、PCA和多重比较校正）加强了工作的稳健性。结论目前的研究结果强调了银屑病在不同人群中的遗传复杂性，并表明它可能与特定的遗传因素没有直接联系。需要进一步的研究来探索环境和遗传相互作用对银屑病发病机制的影响。
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引用次数: 0
Cutaneous metastasis of primary urothelial ureteral cancer: an exceptional case with atypical presentation 原发性尿路上皮输尿管癌的皮肤转移：一个不典型表现的例外病例。
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501265
Martín Céspede-Núñez , Jonathan Stevens , Andrea Solari , Cecilia Jeraldo
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引用次数: 0
Treatment of extensive oral leukoplakia with diode laser – Successful case report 二极管激光治疗广泛性口腔白斑成功病例报告
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501274
Elen de Souza Tolentino , Fábio Vieira de Miranda , Tiago Carvalho dos Santos , Lucas Hideki Suzaki Ikeshoji , Letícia Sant’Anna Arioso , Paulo Sérgio da Silva Santos , Camila Lopes Cardoso
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引用次数: 0
Rapid clinical response in refractory discoid lupus erythematosus treated with anifrolumab 治疗难治性盘状红斑狼疮的快速临床反应
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501284
José Ramos, Hugo Leme, António Magarreiro-Silva
{"title":"Rapid clinical response in refractory discoid lupus erythematosus treated with anifrolumab","authors":"José Ramos,&nbsp;Hugo Leme,&nbsp;António Magarreiro-Silva","doi":"10.1016/j.abd.2025.501284","DOIUrl":"10.1016/j.abd.2025.501284","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 1","pages":"Article 501284"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type IV pityriasis rubra pilaris treated with ixekizumab 用ixekizumab治疗 型IV型毛疹红斑
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501283
Ana Ferreirinha, Alexandre João, Margarida Brito Caldeira
{"title":"Type IV pityriasis rubra pilaris treated with ixekizumab","authors":"Ana Ferreirinha,&nbsp;Alexandre João,&nbsp;Margarida Brito Caldeira","doi":"10.1016/j.abd.2025.501283","DOIUrl":"10.1016/j.abd.2025.501283","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 1","pages":"Article 501283"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extensive discohesive melanoma: additional challenges beyond the Breslow Index 广泛的非粘连性黑色素瘤：brreslow指数之外的额外挑战
IF 3.6 4区 医学 Q2 DERMATOLOGY
Anais brasileiros de dermatologia
Pub Date : 2026-01-01 DOI: 10.1016/j.abd.2025.501251
Danielle Carvalho Quintella , Camila Sampaio Tomé Veloso-de-Araújo , Victor Faber , Ângela de Paiva Ansorge , Tullia Cuzzi
{"title":"Extensive discohesive melanoma: additional challenges beyond the Breslow Index","authors":"Danielle Carvalho Quintella ,&nbsp;Camila Sampaio Tomé Veloso-de-Araújo ,&nbsp;Victor Faber ,&nbsp;Ângela de Paiva Ansorge ,&nbsp;Tullia Cuzzi","doi":"10.1016/j.abd.2025.501251","DOIUrl":"10.1016/j.abd.2025.501251","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 1","pages":"Article 501251"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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