Pub Date : 2025-06-13DOI: 10.1007/s44211-025-00803-y
Asako Shimada, Ko Hemmi, Saki Ohira, Yoshihisa Iida
Advanced liquid processing system (ALPS)-treated water was sampled from the K4-B tank group on March 24, 2022, in the presence of staff from the International Atomic Energy Agency (IAEA) and Tokyo Electric Power Company (TEPCO) Holdings, Inc. The Nuclear Safety Research Center (NSRC) of the Japan Atomic Energy Agency analyzed ten key radionuclides (3H, 14C, 60Co, 90Sr, 99Tc, 106Ru, 125Sb, 129I, 134Cs, and 137Cs) and three additional nuclides (36Cl, 55Fe, and 79Se) in the ALPS-treated water as part of independent monitoring for the regulatory body. According to the obtained results, all radionuclide concentrations, except that for the 3H concentration, were ultralow and less than the standard values permitted for discharge. TEPCO’s analytical results were evaluated using the En number, which indicated satisfactory performance. In addition, reference values and ζ scores obtained via the IAEA’s interlaboratory comparisons were recalculated incorporating the NSRC’s results. All ζ scores for NSRC, IAEA, and TEPCO fell between − 2 and 2, demonstrating that the results are acceptable at a 95.4% confidence level.
{"title":"Analysis and quantification of tritium and other low-level radionuclides present in ALPS-treated water","authors":"Asako Shimada, Ko Hemmi, Saki Ohira, Yoshihisa Iida","doi":"10.1007/s44211-025-00803-y","DOIUrl":"10.1007/s44211-025-00803-y","url":null,"abstract":"<div><p>Advanced liquid processing system (ALPS)-treated water was sampled from the K4-B tank group on March 24, 2022, in the presence of staff from the International Atomic Energy Agency (IAEA) and Tokyo Electric Power Company (TEPCO) Holdings, Inc. The Nuclear Safety Research Center (NSRC) of the Japan Atomic Energy Agency analyzed ten key radionuclides (<sup>3</sup>H, <sup>14</sup>C, <sup>60</sup>Co, <sup>90</sup>Sr, <sup>99</sup>Tc, <sup>106</sup>Ru, <sup>125</sup>Sb, <sup>129</sup>I, <sup>134</sup>Cs, and <sup>137</sup>Cs) and three additional nuclides (<sup>36</sup>Cl, <sup>55</sup>Fe, and <sup>79</sup>Se) in the ALPS-treated water as part of independent monitoring for the regulatory body. According to the obtained results, all radionuclide concentrations, except that for the <sup>3</sup>H concentration, were ultralow and less than the standard values permitted for discharge. TEPCO’s analytical results were evaluated using the <i>En</i> number, which indicated satisfactory performance. In addition, reference values and ζ scores obtained via the IAEA’s interlaboratory comparisons were recalculated incorporating the NSRC’s results. All ζ scores for NSRC, IAEA, and TEPCO fell between − 2 and 2, demonstrating that the results are acceptable at a 95.4% confidence level.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1383 - 1391"},"PeriodicalIF":2.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-12DOI: 10.1007/s44211-025-00801-0
Qun Ma, Yan Xu
Single-molecule studies are increasingly critical across diverse scientific disciplines. While nanofluidics research has significantly advanced in the past decade, translating nanofluidic device fabrication into practical single-molecule analytical applications remains a significant challenge. This review explores the burgeoning field of single-molecule analytical chemistry utilizing nanofluidic devices. We delve into the fundamental mechanisms and technologies enabling single-molecule sampling, isolation, manipulation, detection as well as single-molecule analysis within well-defined nanofluidic channels, highlighting the unique advantages of ultrasmall confined spaces and resulting unusual effects of nanofluidic devices. Despite remarkable progress, critical challenges and promising opportunities abound in this emerging field. This review also discusses future directions for this promising area of single-molecule analytical chemistry based on nanofluidic devices.
{"title":"Nanofluidic devices for single-molecule analytical chemistry","authors":"Qun Ma, Yan Xu","doi":"10.1007/s44211-025-00801-0","DOIUrl":"10.1007/s44211-025-00801-0","url":null,"abstract":"<div><p>Single-molecule studies are increasingly critical across diverse scientific disciplines. While nanofluidics research has significantly advanced in the past decade, translating nanofluidic device fabrication into practical single-molecule analytical applications remains a significant challenge. This review explores the burgeoning field of single-molecule analytical chemistry utilizing nanofluidic devices. We delve into the fundamental mechanisms and technologies enabling single-molecule sampling, isolation, manipulation, detection as well as single-molecule analysis within well-defined nanofluidic channels, highlighting the unique advantages of ultrasmall confined spaces and resulting unusual effects of nanofluidic devices. Despite remarkable progress, critical challenges and promising opportunities abound in this emerging field. This review also discusses future directions for this promising area of single-molecule analytical chemistry based on nanofluidic devices.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1289 - 1304"},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-11DOI: 10.1007/s44211-025-00765-1
Isao Taniguchi
During the past 40 years, bioelectrochemistry and bio-electroanalytical chemistry have developed. Especially, after the 1970s and 80s, protein electrochemistry has changed dramatically, because direct rapid electron-transfer reactions of metalloproteins were found to be observed on simple solid modified electrodes. The surface structures of such functional modified electrodes have also been studied at the atomic and/or molecular level using STM images on the single crystal surfaces to understand the roles of the surface structures. Since then, various electroanalytical techniques have been used to apply to analyze electrochemical behavior of important metalloproteins (i.e., cytochrome c, myoglobin, and ferredoxin) to understand the fundamental origins of their biological functions. In this short review, some of the achievements at the early stage of recent bioelectrochemistry of biologically important metalloproteins to analyze functions of biomolecules and their promising applications to prepare some biological devices, such as sensors and bio-fuel cells, are introduced based on research activities so far done in our group together with brief prospects.
{"title":"Bio-electroanalytical Chemistry = Research Footprint and the Future =","authors":"Isao Taniguchi","doi":"10.1007/s44211-025-00765-1","DOIUrl":"10.1007/s44211-025-00765-1","url":null,"abstract":"<div><p>During the past 40 years, bioelectrochemistry and bio-electroanalytical chemistry have developed. Especially, after the 1970s and 80s, protein electrochemistry has changed dramatically, because direct rapid electron-transfer reactions of metalloproteins were found to be observed on simple solid modified electrodes. The surface structures of such functional modified electrodes have also been studied at the atomic and/or molecular level using STM images on the single crystal surfaces to understand the roles of the surface structures. Since then, various electroanalytical techniques have been used to apply to analyze electrochemical behavior of important metalloproteins (i.e., cytochrome c, myoglobin, and ferredoxin) to understand the fundamental origins of their biological functions. In this short review, some of the achievements at the early stage of recent bioelectrochemistry of biologically important metalloproteins to analyze functions of biomolecules and their promising applications to prepare some biological devices, such as sensors and bio-fuel cells, are introduced based on research activities so far done in our group together with brief prospects.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1115 - 1120"},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-10DOI: 10.1007/s44211-025-00805-w
Domenico C. M. Albanese, Irene Gado, Francesca Vasile
Polyamidoamines obtained through the polyaddition of natural alpha-aminoacids to N,N′-methylenebisacrylamide were shown to be remarkably active flame retardants for cotton. The presence of a disulfide linkage together with phosphorus atoms was previously chosen as desirable structural requirements and added to the polymer chain for their flame retardants properties. The conjugation of cystamine with diethyl vinyl phosphonate to obtain the desired monomer is accompanied by the formation of a by-product that must be identified and characterized to optimize the reaction. The ability of nuclear magnetic resonance to detect and quantify the components of a mixture in solution has become increasingly important in the analysis of manufacturing processes. Here, we have used NMR spectroscopy to identify and quantify an impurity in the synthesis of the precursor of a flame retardant without removing the main product from solution. 1D and 2D NMR spectra were used to obtain the identification and full characterization of the molecules and the by-product was identified through the analysis of different nuclei, such as 1H, 13C, 15N and 31P.
{"title":"Identification and structure elucidation by NMR spectroscopy of an impurity in flame retardants preparation","authors":"Domenico C. M. Albanese, Irene Gado, Francesca Vasile","doi":"10.1007/s44211-025-00805-w","DOIUrl":"10.1007/s44211-025-00805-w","url":null,"abstract":"<div><p>Polyamidoamines obtained through the polyaddition of natural alpha-aminoacids to <i>N,N′</i>-methylenebisacrylamide were shown to be remarkably active flame retardants for cotton. The presence of a disulfide linkage together with phosphorus atoms was previously chosen as desirable structural requirements and added to the polymer chain for their flame retardants properties. The conjugation of cystamine with diethyl vinyl phosphonate to obtain the desired monomer is accompanied by the formation of a by-product that must be identified and characterized to optimize the reaction. The ability of nuclear magnetic resonance to detect and quantify the components of a mixture in solution has become increasingly important in the analysis of manufacturing processes. Here, we have used NMR spectroscopy to identify and quantify an impurity in the synthesis of the precursor of a flame retardant without removing the main product from solution. 1D and 2D NMR spectra were used to obtain the identification and full characterization of the molecules and the by-product was identified through the analysis of different nuclei, such as <sup>1</sup>H, <sup>13</sup>C, <sup>15</sup>N and <sup>31</sup>P.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1413 - 1418"},"PeriodicalIF":2.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-10DOI: 10.1007/s44211-025-00796-8
Yukina Takahashi
We have developed a technique to control the structure of plasmonic nanoparticle–photofunctional material composites at the nanoscale by using analytical chemical methods. We have also developed a highly sensitive sensing system that maximizes the photo-harvesting effect of plasmonic nanoparticles, and a novel photo-detecting system that utilizes a charge separation system at the interface between plasmonic nanoparticles and p-type semiconductors. The research results have been successfully applied to the photocatalyst for hydrogen evolution and the elucidation of the reaction mechanism through analysis and measurement. These research results propose a new method to effectively utilize weak light energy and to dramatically improve environmental and spectroscopic measurement techniques using light. This review outlines our efforts about these topics, primarily based on our recent achievement.
{"title":"Development of photoenergy conversion systems and high-sensitivity sensing using metal nanoparticles","authors":"Yukina Takahashi","doi":"10.1007/s44211-025-00796-8","DOIUrl":"10.1007/s44211-025-00796-8","url":null,"abstract":"<div><p>We have developed a technique to control the structure of plasmonic nanoparticle–photofunctional material composites at the nanoscale by using analytical chemical methods. We have also developed a highly sensitive sensing system that maximizes the photo-harvesting effect of plasmonic nanoparticles, and a novel photo-detecting system that utilizes a charge separation system at the interface between plasmonic nanoparticles and p-type semiconductors. The research results have been successfully applied to the photocatalyst for hydrogen evolution and the elucidation of the reaction mechanism through analysis and measurement. These research results propose a new method to effectively utilize weak light energy and to dramatically improve environmental and spectroscopic measurement techniques using light. This review outlines our efforts about these topics, primarily based on our recent achievement.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1139 - 1144"},"PeriodicalIF":2.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Two reference materials (RMs) were developed at the National Institute for Environmental Studies (NIES) for biomonitoring atmospheric mercury (Hg). First-year pine needles (Pinus thunbergii), reflecting atmospheric conditions over approximately one year were collected from Nara and Ibaraki prefectures and designated as NIES RM No. 1001 Pine Needle I (PN I) and NIES RM No. 1002 Pine Needle II (PN II), respectively. After removing surface dust, the needles were oven-dried at 70 ℃, ground, homogenized, bottled, and sterilized using 60Co irradiation. Homogeneity and long-term stability tests were conducted for total Hg (THg) using cold-vapor atomic absorption spectrometry, confirming the material's suitability as RMs. The THg concentrations of PN I and PN II were 5.4 ± 0.4 ng/g and 22 ± 2 ng/g, respectively, lower than the NIST SRM 1575a Pine Needles (39.9 ± 0.7 ng/g). Given decreasing background levels of atmospheric Hg, precise measurement of low-concentration samples is increasingly important. Hg isotopic analysis was performed using a two-stage furnace or microwave-assisted digestion. Isotopic values for PN I were δ202Hg = –2.63 ± 0.24‰, Δ199Hg = –0.22 ± 0.17‰, Δ200Hg = –0.01 ± 0.10‰, and Δ201Hg = –0.19 ± 0.17‰ (2SD, n = 8), while those for PN II were δ202Hg = –1.64 ± 0.23‰, Δ199Hg = –0.51 ± 0.10‰, Δ200Hg = 0.00 ± 0.06‰, and Δ201Hg = –0.52 ± 0.13‰ (2SD, n = 12). Various trace element concentrations (Al, Ba, Ca, Cd, Cu, Fe, K, P, Rb, and Zn) were also measured. These candidate RMs are suitable for quality control in heavy metal and Hg isotope studies of foliage and similar matrices.
Graphical abstract
国家环境研究所（NIES）开发了两种标准物质，用于生物监测大气汞（Hg）。从奈良县和茨城县收集反映大约一年大气条件的一年生松针（Pinus thunbergii），分别命名为NIES RM No. 1001 pine Needle I （PN I）和NIES RM No. 1002 pine Needle II （PN II）。去除表面粉尘后，70℃烘干，研磨，均质，装瓶，60Co辐照灭菌。采用冷蒸汽原子吸收光谱法对总汞（THg）进行了均匀性和长期稳定性测试，证实了该材料作为均方根值的适用性。PN I和PN II的THg浓度分别为5.4±0.4 ng/g和22±2 ng/g，低于NIST SRM 1575a松针（39.9±0.7 ng/g）。鉴于大气中汞的背景水平不断下降，对低浓度样品的精确测量变得越来越重要。汞同位素分析采用两段炉或微波辅助消解。同位素值PN 202 hgδ= -2.63±0.24‰,Δ199 hg = -0.22±0.17‰,Δ200 hg = -0.01±0.10‰,和Δ201 hg = -0.19±0.17‰(2 sd, n = 8),而PN II 202 hgδ= -1.64±0.23‰,Δ199 hg = -0.51±0.10‰,Δ200 hg = 0.00±0.06‰,Δ201 hg = -0.52±0.13‰(2 sd, n = 12)。还测量了各种微量元素（Al, Ba, Ca, Cd, Cu, Fe， K， P， Rb和Zn）的浓度。这些候选均方根值适用于叶片和类似基质重金属和汞同位素研究的质量控制。
{"title":"Development of pine needle reference materials for atmospheric mercury biomonitoring","authors":"Akane Yamakawa, Kimiyo Nagano, Kaoru Onishi, Miyuki Ukachi, Kozue Inamasu","doi":"10.1007/s44211-025-00802-z","DOIUrl":"10.1007/s44211-025-00802-z","url":null,"abstract":"<div><p>Two reference materials (RMs) were developed at the National Institute for Environmental Studies (NIES) for biomonitoring atmospheric mercury (Hg). First-year pine needles (<i>Pinus thunbergii</i>), reflecting atmospheric conditions over approximately one year were collected from Nara and Ibaraki prefectures and designated as NIES RM No. 1001 Pine Needle I (PN I) and NIES RM No. 1002 Pine Needle II (PN II), respectively. After removing surface dust, the needles were oven-dried at 70 ℃, ground, homogenized, bottled, and sterilized using <sup>60</sup>Co irradiation. Homogeneity and long-term stability tests were conducted for total Hg (THg) using cold-vapor atomic absorption spectrometry, confirming the material's suitability as RMs. The THg concentrations of PN I and PN II were 5.4 ± 0.4 ng/g and 22 ± 2 ng/g, respectively, lower than the NIST SRM 1575a Pine Needles (39.9 ± 0.7 ng/g). Given decreasing background levels of atmospheric Hg, precise measurement of low-concentration samples is increasingly important. Hg isotopic analysis was performed using a two-stage furnace or microwave-assisted digestion. Isotopic values for PN I were δ<sup>202</sup>Hg = –2.63 ± 0.24‰, Δ<sup>199</sup>Hg = –0.22 ± 0.17‰, Δ<sup>200</sup>Hg = –0.01 ± 0.10‰, and Δ<sup>201</sup>Hg = –0.19 ± 0.17‰ (2SD, n = 8), while those for PN II were δ<sup>202</sup>Hg = –1.64 ± 0.23‰, Δ<sup>199</sup>Hg = –0.51 ± 0.10‰, Δ<sup>200</sup>Hg = 0.00 ± 0.06‰, and Δ<sup>201</sup>Hg = –0.52 ± 0.13‰ (2SD, n = 12). Various trace element concentrations (Al, Ba, Ca, Cd, Cu, Fe, K, P, Rb, and Zn) were also measured. These candidate RMs are suitable for quality control in heavy metal and Hg isotope studies of foliage and similar matrices.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1373 - 1382"},"PeriodicalIF":2.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-05DOI: 10.1007/s44211-025-00797-7
Takafumi Shimoaka, Masashi Ootsuki, Yuta Yamaguchi, Nobutaka Shioya, Takeshi Hasegawa
Recently, unique surface properties of poly- and perfluoroalkyl substances (PFAS) have been revealed to be derived from a two-dimensional (2D) packing of perfluoroalkyl (Rf) groups with perpendicularly standing orientation, i.e., the end-on orientation, which is revealed by the stratified dipole arrays (SDA) model. This indicates that analysis of the 2D aggregation of Rf groups is crucial for understanding the PFAS-specific properties, and analysis of the primary structure alone is insufficient. In the present study, we employ an analytical method of backscattering Raman spectrometry to explore the 2D aggregation of Rf groups in terms of molecular orientation. Measurements of solid particles of perfluoro-n-alkane with theoretical consideration of the Raman activity on backscattering optical arrangement make us find useful marker bands derived from the Rf groups. Analysis of the band enables us to determine the end-on orientation of the Rf chain about the surface of bulk PFAS: when the Rf chains are end-on oriented, the bands assigned to a specific symmetry species selectively disappear, whereas the other Raman-active bands remain. In short, the disappearance of the marker bands makes us determine the end-on orientation very easily. In addition, we demonstrate that the marker band can be used to visualize in-plane distribution of the end-on orientation by utilizing mapping measurements.
{"title":"Molecular orientation analysis of perfluoroalkyl groups in the solid surface by backscattering Raman spectrometry","authors":"Takafumi Shimoaka, Masashi Ootsuki, Yuta Yamaguchi, Nobutaka Shioya, Takeshi Hasegawa","doi":"10.1007/s44211-025-00797-7","DOIUrl":"10.1007/s44211-025-00797-7","url":null,"abstract":"<div><p>Recently, unique surface properties of poly- and perfluoroalkyl substances (PFAS) have been revealed to be derived from a two-dimensional (2D) packing of perfluoroalkyl (R<sub>f</sub>) groups with perpendicularly standing orientation, i.e., the end-on orientation, which is revealed by the stratified dipole arrays (SDA) model. This indicates that analysis of the 2D aggregation of R<sub>f</sub> groups is crucial for understanding the PFAS-specific properties, and analysis of the primary structure alone is insufficient. In the present study, we employ an analytical method of backscattering Raman spectrometry to explore the 2D aggregation of R<sub>f</sub> groups in terms of molecular orientation. Measurements of solid particles of perfluoro-<i>n</i>-alkane with theoretical consideration of the Raman activity on backscattering optical arrangement make us find useful marker bands derived from the R<sub>f</sub> groups. Analysis of the band enables us to determine the end-on orientation of the R<sub>f</sub> chain about the surface of bulk PFAS: when the R<sub>f</sub> chains are end-on oriented, the bands assigned to a specific symmetry species selectively disappear, whereas the other Raman-active bands remain. In short, the disappearance of the marker bands makes us determine the end-on orientation very easily. In addition, we demonstrate that the marker band can be used to visualize in-plane distribution of the end-on orientation by utilizing mapping measurements.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1355 - 1364"},"PeriodicalIF":2.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, we proposed a novel detection concept using aptamer DNA based on particle dissociation in a coupled acoustic-gravitational (CAG) field. When the CAG field was formed in the channel, the PS particles on the glass plate exerted the acoustic radiation force (Fac), sedimentation force (Fsed), and binding force between the PS particle and glass plate (Fbind). The applied voltage to the transducer (V) required for particle dissociation from the glass plate depends on the Fbind. When the arginine is introduced to the system, in which the PS particles are immobilized onto the glass plate through the DNA hybridization using aptamer for arginine, the change in Fbind can be induced, allowing us to detect the arginine concentration as the change in V. Thus, we demonstrated a detection concept for arginine that enables rough concentration estimation despite the limited precision.
{"title":"Detection scheme of arginine as aptamer target based on particle dissociation in coupled acoustic-gravitational field","authors":"Akihisa Miyagawa, Koki Nakano, Kengo Oshiyama, Shigenori Nagatomo, Kiyoharu Nakatani, Shoji Ishizaka","doi":"10.1007/s44211-025-00798-6","DOIUrl":"10.1007/s44211-025-00798-6","url":null,"abstract":"<div><p>In this study, we proposed a novel detection concept using aptamer DNA based on particle dissociation in a coupled acoustic-gravitational (CAG) field. When the CAG field was formed in the channel, the PS particles on the glass plate exerted the acoustic radiation force (<i>F</i><sub>ac</sub>), sedimentation force (<i>F</i><sub>sed</sub>), and binding force between the PS particle and glass plate (<i>F</i><sub>bind</sub>). The applied voltage to the transducer (<i>V</i>) required for particle dissociation from the glass plate depends on the <i>F</i><sub>bind</sub>. When the arginine is introduced to the system, in which the PS particles are immobilized onto the glass plate through the DNA hybridization using aptamer for arginine, the change in <i>F</i><sub>bind</sub> can be induced, allowing us to detect the arginine concentration as the change in <i>V</i>. Thus, we demonstrated a detection concept for arginine that enables rough concentration estimation despite the limited precision.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1407 - 1412"},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-04DOI: 10.1007/s44211-025-00799-5
Zaitoon Khan, Nimra Khan, Mithra Geetha, Reyhanath Pilakka Veettil, Deepak Mahadev Kasote, Anwarul Hasan, Kishor Kumar Sadasivuni
Cancer remains a pressing global health concern, burdening individuals, families, and healthcare systems worldwide, mainly because of the limited availability of therapeutic options. These days, nanotechnology is revolutionizing cancer research by offering promising drug delivery systems. Among these, nanobots and nanocarriers are key nanotechnology components, offering groundbreaking strategies in cancer therapy by delivering drugs, enhancing diagnostics, and preventing diseases at molecular levels. Nanobots and nanocarriers, engineered at sizes ranging from 1 to 100 nm, demonstrate biocompatibility with cellular systems, offer precise drug delivery, and reduce side effects compared to conventional therapies such as chemotherapy and surgery. Research efforts now focus on transitioning nanobots and nanocarriers from laboratories to clinics, aiming for precision medicine, targeted drug delivery, enhanced therapy efficacy, and minimal side effects. This review aims to highlight the potential of nanobots and nanocarriers in cancer treatment and provide insights into their role in paving the way for clinical applications and improving outcomes in cancer therapy.
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