Novel pocket-independent STING-activating agonists (piSTINGs), which act through multivalency-driven oligomerization to activate downstream signalling pathways, were developed by Yan-Mei Li et al. in their Research Article (e202407037). piSTINGs could serve as novel STING agonists for vaccines and combination therapies. STING oligomerization is a useful strategy for the development of a new generation of STING agonists.