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Management of Recurrent Nasal Vestibular Furunculosis by Jalaukāvacaraṇa and Palliative Treatment. Jalaukāvacaraṇa治疗复发性鼻前庭疖病及姑息治疗。
Pub Date : 2017-04-01 DOI: 10.4103/asl.ASL_190_15
Amol Sudhakar Kadu, Dhirajsingh Sumersingh Rajput, Sourabh G Deshmukh

Nasal vestibular furunculosis is a common bacterial skin infection among the general population mostly affecting adults and children. It is characterized by acute localized infection of hair follicle in the skin lining of the nasal vestibule caused by Staphylococcus aureus. Immunodeficiency also plays an important role in recurrent skin and soft tissue infections (SSTI) including Nasal furunculosis. Though, the lesion is small, it is extremely painful and tender. Treatment is mostly conservative which consists of warm compresses, analgesics to relieve pain, topical and systemic antibiotics directed against staphylococcus. With rapidly increasing resistance to antibacterial agents, management of these bacterial infections is becoming increasingly difficult. In Ayurveda, it can be correlated with Nāsāruṇaśikhā (Nasal furunculosis). Morphologically, it appears like pīḍikā (Furuncle) which is characterized by Rāgayuktaśotha (inflammation with reddening. Jalaukāvacaraṇa (Leech therapy) is one of the ancient and important parasurgical procedures described in Ayurveda for treatment of various diseases. In this case, a leech has been applied at the affected area. After leech treatment, throbbing pain was reduced in its intensity followed by gradual reduction in swelling and reddening in two days. This case suggests the utility of leech application in Nasal vestibular furunculosis.

鼻前庭疖病是一种在普通人群中常见的细菌性皮肤感染,主要影响成人和儿童。它的特征是由金黄色葡萄球菌引起的鼻前庭皮肤内膜毛囊急性局部感染。免疫缺陷也在复发性皮肤和软组织感染(SSTI)中起重要作用,包括鼻疖病。虽然病灶很小,但非常疼痛和柔软。治疗大多是保守的,包括热敷,止痛剂,局部和全身抗生素直接针对葡萄球菌。随着对抗菌剂的耐药性迅速增加,这些细菌感染的管理变得越来越困难。在阿育吠陀,它可以与Nāsāruṇaśikhā(鼻疖病)相关。形态学上表现为pīḍikā(疖),其特征为Rāgayuktaśotha(炎症伴发红)。Jalaukāvacaraṇa(水蛭疗法)是阿育吠陀中描述的用于治疗各种疾病的古老而重要的辅助外科手术之一。在这种情况下,已经在患处应用了水蛭。水蛭治疗后,搏动痛的强度减轻,肿胀和发红在两天内逐渐减轻。本病例提示水蛭在鼻前庭疖病中的应用。
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引用次数: 6
A Case Study on Successful Ayurvedic Management of a Rare Case of Reiter's Syndrome. 阿育吠陀治疗一例罕见瑞特综合征的成功案例研究。
Pub Date : 2017-04-01 DOI: 10.4103/asl.ASL_89_16
Vaishali Kuchewar

Reiter's syndrome is a clinical syndrome of arthritis, urethritis, conjunctivitis, and mucocutaneous lesions. Skin and mucosal involvement is observed in about 10% of the cases. A 34-year-old male was brought in severe condition. He had red colored foul smelling maculopapular skin lesions all over body, swollen and painful knee and shoulder joints. History revealed that he was suffering from Reiter's syndrome since 2003. He used to get admitted between the months of February and May every year due to aggravation of symptoms. Every time he was treated with systemic antibiotics, corticosteroids, immunosuppressants and non-steroidal anti-inflammatory drugs. He was successfully treated with external application and internal medication with tikta (bitter) and kaṣāya (astringent) drugs. He got significant relief in skin lesions as well as joint pain and his quality of life was markedly improved. This case study demonstrates that Reiter's syndrome can be well managed with Ayurvedic medicines.

瑞特综合征是一种关节炎、尿道炎、结膜炎和皮肤粘膜病变的临床综合征。约10%的病例累及皮肤和粘膜。一名34岁的男性病情严重。全身有红色、恶臭的斑疹样皮损,膝关节、肩关节肿痛。历史显示,自2003年以来,他一直患有莱特综合症。每年的2 ~ 5月,他都会因症状加重而住院。每次他都接受全身抗生素、皮质类固醇、免疫抑制剂和非甾体抗炎药的治疗。患者经外敷和内服苦药tikta和涩药kaṣāya治疗成功。患者的皮肤病变和关节疼痛明显减轻,生活质量明显改善。本案例研究表明,阿育吠陀药物可以很好地治疗瑞特综合征。
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引用次数: 3
A Metallurgical Study of Nāga Bhasma. Nāga Bhasma的冶金研究。
Pub Date : 2017-04-01 DOI: 10.4103/asl.ASL_206_15
Dev Nath Singh Gautam

Background: The metal Nāga (Lead) is being used by Indians since ancient times. Its external and internal uses have been described in Caraka, Suśruta and other Ayurvedic Saṃhitā. According to most of the Rasa texts, Nāga Bhasma and its formulations are used in many diseases such as Prameha, Jvara, Gulma, Śukrameha etc.

Objectives: In the present study, Nāga Bhasma was prepared by the traditional Puṭa method (TPM) and by the electric muffle furnace Puṭa method (EMFPM) and standardized using Metallographic studies. Doing so helps in the study of the microstructure of Nāga Bhasma and also helps in the identification of the metal particles along with the nature of compound formed during the Māraṇa (Bhasmīkaraṇa) process.

Setting and design: Different samples from initial raw material to final product of Nāga Bhasma were collected during the pharmaceutical process (1st, 30th and 60thPuṭa) from both methods i.e. TPM and EMFPM. Samples from both methods were studied using metallographic examination.

Materials and methods: The processing of the Nāga Bhasma (ṣaṣṭipuṭa) was done according to Ānanda Kanda[9] Samples from the raw material i.e. Aśodhita Nāga (raw Lead) and that processed after 1st, 30th and 60th Puṭa from both methods i.e. traditional Puṭa method (using heat from burning of cow dung cakes) and electric muffle furnace Puṭa method were taken. They were mounted on self hardening acrylic base. After careful polishing to obtain scratch free surface of product, they were used for metallurgical study.

Conclusion: This study shows that traditional Puṭa method may be better than electric muffle furnace Puṭa method because of more homogeneous distribution of Lead sulphide in the Nāga Bhasma which is prepared by traditional method.

背景:金属Nāga(铅)自古以来就被印度人使用。在卡拉卡,Suśruta和其他阿育吠陀Saṃhitā中描述了它的外部和内部用途。根据大多数Rasa文本,Nāga Bhasma及其配方用于许多疾病,如Prameha, Jvara, Gulma, Śukrameha等。目的:在本研究中,Nāga Bhasma采用传统的Puṭa方法(TPM)和电马弗炉Puṭa方法(EMFPM)制备,并采用金相研究进行标准化。这样做有助于研究Nāga Bhasma的微观结构,也有助于识别金属颗粒以及Māraṇa (Bhasmīkaraṇa)过程中形成的化合物的性质。设定与设计:在制药过程中(1日、30日和60thPuṭa),采用TPM和EMFPM两种方法,从初始原料到最终产品Nāga Bhasma收集不同的样品。用金相检验对两种方法的样品进行了研究。材料和方法:根据Ānanda Kanda[9]对Nāga Bhasma (ṣaṣṭipuṭa)进行加工,样品取自原材料Aśodhita Nāga(生铅)和1日、30日和60日Puṭa之后加工的样品,分别采用传统Puṭa法(利用牛粪饼燃烧产生的热量)和电马弗炉Puṭa法。它们被安装在自硬化丙烯酸基上。经过仔细的抛光,使产品表面无划痕,用于冶金研究。结论:由于传统方法制备的Nāga Bhasma中硫化铅的分布更为均匀,因此传统Puṭa方法可能优于电马弗炉Puṭa方法。
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引用次数: 1
Effect of Bhrāmarī Prāṇāyāma Practice on Pulmonary Function in Healthy Adolescents: A Randomized Control Study. Bhrāmarī Prāṇāyāma锻炼对健康青少年肺功能的影响:一项随机对照研究
Pub Date : 2017-04-01 DOI: 10.4103/asl.ASL_220_16
Maheshkumar Kuppusamy, K Dilara, P Ravishankar, A Julius

Context: Prāṇāyāma, the fourth limb of ancient aṣṭāṅga yoga consists of breathing techniques which produce various physiological and psychological effects. Though various types of prāṇāyāma and their effects have been scientifically established, Bhrāmarī prāṇāyāma (Bhr.P) is the one whose effects still remain understated.

Aims: The present study was conducted to find the effects of Bhrāmarī prāṇāyāma practice on pulmonary function in healthy adolescents.

Study design: Randomized control trial.

Subjects and methods: 90 healthy adolescents including 32 females and 58 males participated in the study. They were randomly divided into Bhr.P group (n = 45) and Control group (n = 45) by a simple lottery method. Pulmonary function test was done at baseline and at end of 12th week using RMS Helios spirometry. Prāṇāyāma group students were trained to do Bhr.P as 3 to 4 breaths/min for 5 min followed by 2 min rest. This was one cycle and in this way, they were instructed to do five cycles each time for 45 minutes five days in a week. Control group students were not allowed to practice any kind of exercise throughout the study period.

Statistical analysis: Student paired and unpaired T tests were used to analyse the intra group and intergroup differences using R statistical software.

Results: A significant (P < 0.05) improvement in all pulmonary function parameters; FVC, FEV1, FEV1/FVC ratio, FEF 25%-75% and PEFR was seen in the Bhr.P group than the control group adolescents. Slow vital capacity (SVC) and Maximum Voluntary Volume (MVV) also showed significant improvement in the prāṇāyāma group.

Conclusions: Bhrāmarī Prāṇāyāma practice is effective in improving the pulmonary function among the adolescents which could be utilized for further clinical studies.

背景:Prāṇāyāma,古代的第四分支aṣṭāṅga瑜伽由呼吸技巧组成,产生各种生理和心理效果。虽然各种类型的prāṇāyāma及其影响已经被科学地证实,但Bhrāmarī prāṇāyāma (Bhr.P)的影响仍然被低估。目的:探讨Bhrāmarī prāṇāyāma运动对健康青少年肺功能的影响。研究设计:随机对照试验。研究对象与方法:90名健康青少年,其中女性32名,男性58名。他们被随机分为两组。P组(n = 45)和对照组(n = 45)采用简单摇号法。在基线和第12周末使用RMS Helios肺活量测定仪进行肺功能测试。Prāṇāyāma组的学生被训练做Bhr。P为3 - 4次呼吸/分钟,持续5分钟,然后休息2分钟。这是一个周期,通过这种方式,他们被指示做五个周期,每次45分钟,一周5天。对照组学生在整个研究期间不允许进行任何形式的练习。统计分析:使用R统计软件,采用学生配对和非配对T检验分析组内和组间差异。结果:两组患者肺功能指标均有显著改善(P < 0.05);Bhr中FVC、FEV1、FEV1/FVC比值、FEF 25% ~ 75%、PEFR。P组青少年明显高于对照组。慢速肺活量(SVC)和最大自愿容积(MVV)在prāṇāyāma组也有显著改善。结论:Bhrāmarī Prāṇāyāma治疗可有效改善青少年肺功能,为进一步的临床研究提供参考。
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引用次数: 14
Autoimmune Bullous Skin Disease Managed with Ayurvedic Treatment: A Case Report. 阿育吠陀治疗自身免疫性大疱性皮肤病一例报告
Pub Date : 2017-04-01 DOI: 10.4103/asl.ASL_91_16
Rahul K Shingadiya, Rohit Sharma, Prashant Bedarkar, Pradeep Kumar Prajapati

Autoimmune bullous diseases are a group of rare, acquired disorders characterized by overlapping features, resistance to treatment, and potential fatality. They need quick and proper management to avoid fatal complications. Ayurveda is found to provide better relief in some autoimmune disorders. Herein, we report a 40-year-old male of autoimmune bullous skin disorder (Visphoṭaka) who failed to respond to allopathic medicines and was subsequently treated with Ayurvedic medicines and achieved complete remission.

自身免疫性大疱性疾病是一组罕见的、获得性疾病,其特点是特征重叠、对治疗有耐药性和潜在的致死率。他们需要快速和适当的治疗,以避免致命的并发症。阿育吠陀被发现能更好地缓解一些自身免疫性疾病。在此,我们报告了一位患有自身免疫性大疱性皮肤病(Visphoṭaka)的40岁男性患者,他对对抗疗法药物没有反应,随后用阿育吠陀药物治疗并完全缓解。
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引用次数: 1
Protective Effect of Standardized Extract of Passiflora incarnata Flower in Parkinson's and Alzheimer's Disease. 西番莲花标准提取物对帕金森病和阿尔茨海默病的保护作用。
Pub Date : 2017-04-01 DOI: 10.4103/asl.ASL_231_16
Suvarna P Ingale, Sanjay B Kasture

Background: Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Flavonoids exert their antioxidant effects by neutralizing all types of oxidizing radicals including the superoxide and hydroxyl radicals. Passiflora incarnata Linn. (Passifloraceae) is an important plant used in Ayurveda for the treatment of various disorders of the CNS and is a rich source of flavonoids.

Aim: In the present study, we investigated the antioxidant, antiparkinsonian, and memory enhancing activity of flavonoid rich n-butanol extract of P. incarnata flowers (BEPIF).

Materials and methods: Antioxidant activity was assessed using DPPH and hydrogen peroxide scavenging assay. The antiparkinsonian activity was evaluated using haloperidol induced catalepsy and tacrine induced vacuous chewing movement and memory enhancing activity was assessed using elevated plus maze and object recognition test.

Statistical analysis: The results were analyzed by Analysis of Variance test followed by Dunnett's test.

Results: Administration of BEPIF decreased transfer latency on day 2 and 9 significantly in elevated plus maze test and showed a significant increase in discrimination index in the object recognition test which is suggestive of its cognitive improvement action. Pretreatment with BEPIF showed a significant reduction in the haloperidol induced catalepsy and the tacrine induced jaw movements which are suggestive of its antiparkinsonian activity. In DPPH and H2O2 scavenging assay, BEPIF exhibited significant free radical scavenging activity.

Conclusions: It can be concluded that the butanolic extract of P. incarnata flowers has significant antiparkinsonian and cognition enhancing activity which may be associated with its antioxidant potential. Thus, P. incarnata flowers may be employed in treatment of dementia and parkinsonism.

背景:氧化应激在阿尔茨海默病和帕金森病等神经退行性疾病的发病机制中起重要作用。黄酮类化合物通过中和所有类型的氧化自由基(包括超氧化物和羟基自由基)来发挥其抗氧化作用。西番莲(Passifloraceae)是阿育吠陀(Ayurveda)中用于治疗各种中枢神经系统疾病的重要植物,是黄酮类化合物的丰富来源。目的:研究牛皮花富黄酮正丁醇提取物(BEPIF)的抗氧化、抗帕金森和增强记忆活性。材料和方法:采用DPPH和过氧化氢清除法测定抗氧化活性。采用氟哌啶醇诱导的猝睡和他克林诱导的空洞咀嚼运动评估抗帕金森活性,采用升高+迷宫和物体识别测试评估记忆增强活性。统计分析:采用方差分析检验和Dunnett检验对结果进行分析。结果:BEPIF在第2天和第9天的升高+迷宫测试中显著降低了转移潜伏期,在物体识别测试中显著提高了辨别指数,提示其具有认知改善作用。BEPIF预处理显示氟哌啶醇诱导的猝倒和他克林诱导的下颌运动显著减少,这提示其抗帕金森活性。在DPPH和H2O2清除实验中,BEPIF表现出明显的自由基清除活性。结论:马齿苋花丁醇提取物具有显著的抗帕金森和增强认知活性,这可能与其抗氧化作用有关。因此,红花可用于治疗痴呆和帕金森病。
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引用次数: 16
An Open Label, Randomized, Comparative, Parallel Group, Multicenter, Prospective, Interventional, Clinical Study to Evaluate Efficacy and Safety of "AHPL/AYTOP/0113" in Comparison with "Framycetin Sulphate Cream" in Acute Wounds. 一项开放标签、随机、比较、平行组、多中心、前瞻性、干预性临床研究:评价“AHPL/AYTOP/0113”与“硫酸框架霉素乳膏”在急性伤口治疗中的疗效和安全性。
Pub Date : 2017-01-01 DOI: 10.4103/asl.ASL_52_16
Sanjay U Nipanikar, Kamalakar V Gajare, Vidyadhar G Vaidya, Amol B Kamthe, Sachin A Upasani, Vidyadhar S Kumbhar

Objectives: The main objective of the present study was to assess efficacy and safety of AHPL/AYTOP/0113 cream, a polyherbal formulation in comparison with Framycetin sulphate cream in acute wounds.

Methodology: It was an open label, randomized, comparative, parallel group and multi-center clinical study. Total 47 subjects were randomly assigned to Group-A (AHPL/AYTOP/0113 cream) and 42 subjects were randomly assigned to Group-B (Framycetin sulphate cream). All the subjects were advised to apply study drug, thrice daily for 21 days or up to complete wound healing (whichever was earlier). All the subjects were called for follow up on days 2, 4, 7, 10, 14, 17 and 21 or up to the day of complete wound healing. Data describing quantitative measures are expressed as mean ± SD. Comparison of variables representing categorical data was performed using Chi-square test.

Results: Group-A subjects took significantly less (P < 0.05) i.e., (mean) 7.77 days than (mean) 9.87 days of Group-B subjects for wound healing. At the end of the study, statistically significant better (P < 0.05) results were observed in Group-A than Group-B in mean wound surface area, wound healing parameters and pain associated with wound. Excellent overall efficacy and tolerability was observed in subjects of both the groups. No adverse event or adverse drug reaction was noted in any subject of both the groups.

Conclusion: AHPL/AYTOP/0113 cream proved to be superior to Framycetin sulphate cream in healing of acute wounds.

目的:本研究的主要目的是评估AHPL/AYTOP/0113乳膏(一种多草药制剂)与硫酸Framycetin乳膏在急性伤口中的疗效和安全性。方法:采用开放标签、随机、比较、平行组、多中心临床研究。将47例受试者随机分为a组(AHPL/AYTOP/0113乳膏),42例受试者随机分为b组(硫酸Framycetin乳膏)。建议所有受试者应用研究药物,每日三次,持续21天或直至伤口完全愈合(以较早者为准)。随访时间分别为第2、4、7、10、14、17、21天或至创面完全愈合当天。描述定量测量的数据以mean±SD表示。代表分类数据的变量比较采用卡方检验。结果:a组创面愈合时间(平均)7.77 d显著少于b组创面愈合时间(平均)9.87 d (P < 0.05)。研究结束时,a组平均创面面积、创面愈合参数及创面相关疼痛均优于b组,差异有统计学意义(P < 0.05)。两组患者均表现出良好的总体疗效和耐受性。两组受试者均未发现不良事件或药物不良反应。结论:AHPL/AYTOP/0113乳膏对急性伤口的愈合效果优于硫酸弗拉米霉素乳膏。
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引用次数: 3
Need to strategize standardization of Indian systems of medicine 需要制定印度医疗系统标准化的战略
Pub Date : 2017-01-01 DOI: 10.4103/asl.ASL_73_18
K. Kumar
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引用次数: 0
Predatory Conferences in the Field of Ayurveda and Alternative Medicine: Need for Quality Checks. 阿育吠陀和替代医学领域的掠夺性会议:需要质量检查。
Pub Date : 2017-01-01 DOI: 10.4103/asl.ASL_128_17
P Ram Manohar
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引用次数: 3
In vitro antioxidant and antimicrobial activities of ethanolic extracts from whole plants of three Impatiens species (balsaminaceae) 三种凤仙花(香脂科)全株乙醇提取物的体外抗氧化和抗菌活性
Pub Date : 2017-01-01 DOI: 10.4103/asl.ASL_162_17
F. Delgado-Rodríguez, Olman Hidalgo, Arlene Loría-Gutiérrez, Nien Weng-Huang
Context: Plants of Impatiens genus are recognized source of extracts with antioxidant and antimicrobial activity, including I. balsamina(Sanskrit name: Tairini), a plant traditionally used in Asia to treat infections and inflammation. However, there is little information related to activities of whole plant extracts. Aim: To investigate the in vitro antioxidant and antimicrobial activities of the ethanolic extract from whole plant of I. balsamina, I. hawkeri and I. walleriana. Methods: Whole plant material of each species was macerated with ethanol (80% v/v). Phytochemical screening was applied for detection of different metabolites. Total phenolic content (TPC) and total flavonoids content (TFC) were determined using Folin-Ciocalteu and aluminum chloride methods respectively. In vitro antioxidant properties were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, potassium ferricyanide antioxidant reducing power (PFRAP) and oxygen radical absorbance capacity (ORAC) assays. In vitro antimicrobial activity of extracts was evaluated against Staphylococcus aureus(ATCC 29737), Staphylococcus epidermidis (ATCC 12228), Streptococcus pyogenes (ATCC 19615), Streptococcus pneumoniae (clinical isolate), Pseudomonas aeruginosa (ATCC 9027), Escherichia coli(ATCC 10536), Candida albicans (ATCC 10231) and Aspergillus niger (ATCC 16404) using microdilution assay for minimal inhibitory concentration (MIC) assessment. Statistical Analysis Used: Results were expressed as mean ± SD. Data obtained were analyzed statistically using ANOVA (one-way) followed by Tukey's post hoc test. Correlation analyses were performed using Pearson correlation test. Results: I. hawkeri extract showed the highest phenolic content (TPC: 44.04 mg GAE/g; TFC: 55, 02 mg QE/g) and was the most antioxidant extract. I. balsamina extract was the most active against all Gram positive bacteria (MIC: 2.5-10 mg/ml) tested and> over C. albicans (MIC: 10 mg/ml). This extract also showed the widest antimicrobial spectrum. Conclusions: The evaluated Impatiens whole plant extracts are also promising sources of antioxidant and antimicrobial agents.
背景:凤仙花属植物是公认的具有抗氧化和抗菌活性的提取物来源,包括凤仙花(梵文名称:Tairini),一种在亚洲传统上用于治疗感染和炎症的植物。然而,有关全植物提取物活性的信息很少。目的:研究香薷、hawkeri和walleriana全株乙醇提取物的体外抗氧化和抗菌活性。方法:采用乙醇(80% v/v)浸泡整株植物。采用植物化学筛选法检测不同代谢产物。采用福林- ciocalteu法和氯化铝法分别测定总酚含量(TPC)和总黄酮含量(TFC)。采用2,2-二苯基-1-苦味酰肼(DPPH)自由基清除能力、铁氰化钾抗氧化还原能力(PFRAP)和氧自由基吸收能力(ORAC)等方法评价其体外抗氧化性能。采用微量稀释法对金黄色葡萄球菌(ATCC 29737)、表皮葡萄球菌(ATCC 12228)、化脓性链球菌(ATCC 19615)、肺炎链球菌(临床分离株)、铜绿假单胞菌(ATCC 9027)、大肠杆菌(ATCC 10536)、白色念珠菌(ATCC 10231)和黑曲霉(ATCC 16404)进行体外抑菌活性评估。统计分析方法:结果以mean±SD表示。所得数据采用单因素方差分析(ANOVA)进行统计学分析,然后进行Tukey事后检验。采用Pearson相关检验进行相关分析。结果:hawkeri提取物中酚类物质含量最高(TPC: 44.04 mg GAE/g;TFC: 55, 02 mg QE/g),是最具抗氧化性的提取物。香脂提取物对革兰氏阳性菌(MIC: 2.5 ~ 10 mg/ml)的抑制作用最强,对白色念珠菌(MIC: 10 mg/ml)的抑制作用最强。该提取物也显示出最广泛的抗菌谱。结论:所评价的凤仙花全植物提取物具有良好的抗氧化和抗菌活性。
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引用次数: 8
期刊
Ancient Science of Life
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