Annals of ophthalmology最新文献

We report a 61-year-old who developed candidemia following pancreatic tumor surgery, and presented with bilateral multifocal chorioretinitis and vitritis. Chorioretinal lesions regressed with fluconazole therapy. Pars plana vitrectomy was performed with resultant improved visual acuity, but vitritis recurred with the next chemotherapy session. With the cessation of chemotherapy, vitritis regressed without any systemic treatment.

We assessed and compared the retinal nerve fiber layer (RNFL) thickness in normal eyes, ocular hypertensives, preperimetric glaucoma and glaucomatous subjects by means of optical coherence tomography in 449 eye. RNFL in glaucoma patients was significantly thinner than in normal subjects in every location evaluated. Use of optical coherence tomography detects glaucomatous RNFL losses in preperimetric glaucoma and can improve our ability to detect structural damage in clinical practice.

We investigated the ability of blue-on-yellow perimetry (B/ YP) to identify the visual field loss in pituitary tumor (PT). All subjects underwent white-on-white perimetry (W/WP) and B/YP tests with Humphrey field analyzer 750i, program 30-2, full threshold. The efforts to detect visual field loss in PT patients with the chiasmal compression could be improved using B/YP in clinical practice.

Apert's syndrome is a rare form of craniosynostosis that exhibits with many ocular manifestations. We present two cases of Apert's syndrome. Our first case is a 10-year-old girl admitted with exotropia, V pattern and proptosis on examination. Investigations revealed coronal craniosynostosis, cleft palate, vaginal atresia and syndactyly of the hands and feet. The second case is a 5-year-old boy presented with hypertelorism, exotropia, dissociated vertical deviation and proptosis. Investigations revealed coronal craniosynostosis, bifid uvula and syndactyly of the hands and feet.

Clinicians are confronted with a plethora of new machines, new software, and new applications of technology, all intended to help with glaucoma management. It is helpful to return to basic principles, to see how these advances fit into our assessment of the intraocular pressure, optic nerve, and visual fields.

The efficacy of combined oral corticosteroid and low-dose oral methotrexate pulsed therapy in Eales' disease was evaluated prospectively, based on weighted visual morbidity scale for disease activity and visual acuity grading in 36 consecutive cases. Oral corticosteroids in a weekly tapering dose for 4 weeks and 12.5 mg methotrexate as a single oral dose, once per week for 12 weeks, were administered simultaneously. We concluded that this combined oral therapy is clinically effective with an acceptable safety profile.

We compared the ability to discriminate between healthy and glaucomatous eyes of three optical imaging devices in 140 eyes from 140 subjects. No statistically significant differences were found among the AUCs of these parameters. However, AUCs were significantly higher in OCT and HRT parameters than most of GDx VCC ones. Thus, structural parameters assessed by the optical imaging devices are useful to discriminate glaucomatous damage, but showed no significant difference among the best parameters from HRT, OCT or GDx VCC.

Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, is a low-grade lymphoma usually occurring after the age of 50 years. We present a case of a 60-year-old man with cutaneous manifestations of MF, who later developed bilateral eyelid ulceration. MF is a highly recalcitrant disease with a relentless course. Our patient highlights a delayed presentation in MF with bilateral upper lid ulcerative lesions, which responded well to systemic chemotherapy, commenced for a visceral indication.

We used the selective staining properties of trypan blue to demonstrate the efficacy and safety of the stain during endothelial keratoplasty (EK) surgery in 55 eyes of 51 patients. No long-term effects were seen due to the trypan blue staining up to two years postoperatively. Trypan blue facilitates the viewing and placement of the donor corneal disc into the recipient anterior chamber through a patient's cloudy cornea.