We investigated glucocorticoids-induced alteration of bFGF in AqH, FGFR and beta-crystallin in rat lens epithelial cells (LECs). Results. Data showed dexamethasone had no effect on bFGF in AqH, but reduced FGFR1 in LECs. After six months treatment, cells were detected under posterior capsule in 4/12 lenses. In vitro observations revealed a down-regulated FGFR1 or beta-crystallin by dexamethasone. FGFR in LECs may play an important role in formation of glucocorticoid-induced PSC.
A 68-year-old lady presented with irritation in left eye of one-week duration. Examination of her left eye revealed loose corneoscleral sutures with corneal vascularization and white deposit in the cornea in front of the blood vessels. She underwent laser photocoagulation but later developed necrotizing scleritis. We report a rare complication of necrotizing scleritis following laser photocoagulation of the corneal new vessels.
The effect of soft contact lens on the limbal stem cells was assessed in 30 contact lens wearers, 19 controls, and 17 cases known to cause limbal stem cell deficiency. Different results were seen as compared to controls in all the four quadrants, but more severe in cases known to cause limbal stem cell deficiency.
We describe a new surgical technique, namely, upside-down phacoemulsification and posterior chamber intraocular lens implantation combined with Descemet's stripping automated endothelial keratoplasty (DSAEK). This technique is aimed at decreasing potential complications associated with conventional phacoemulsification, including posterior lens capsular tear and vitreous loss during DSAEK and cataract surgery performed through a cloudy cornea.
We report an unusual case of angle closure glaucoma in a patient with the skin lymphoma mycosis fungoides. Constant eye rubbing led to bilateral lens subluxation and uncontrolled intraocular pressure.
We present a case of silent sinus syndrome (SSS) who underwent unilateral surgical endoscopic maxillary meatotomy. Orbital floor reconstruction is delayed after follow up. Enophthalmos recovered 8 months after the surgery and radiologic findings improved. SSS is a clinical entity that should be kept in mind in the differential diagnosis of enophthalmos and can be treated successfully via endoscopic approach.
A 70-year-old man right eye over 5 weeks. He was found clinically to have a bitemporal hemianopia and bilateral disc edema. Testing revealed optic nerve head drusen (ONHD) bilaterally causing enlarged blind spots (pseudo-bitemporal hemianopia). This case illustrates that ONHD should be listed in the differential diagnosis for bitemporal hemianopia when brain imaging is normal.
We report fundus autofluorescence and spectral optical coherence tomography (OCT/SLO) findings in acute posterior multifocal placoid pigment epitheliopathy (APMPPE). Different autofluorescence patterns and OCT findings were observed during the acute and resolution phase of the disease. The combined use of new non-invasive technologies may put new insight to the explanation of the histopathology and etiology of APMPPE.
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