As an essential biomarker for diagnosing and treating various diseases, low-cost, quantitative detection methods for complementary DNA (cDNA) have received much attention. The surface plasmon resonance (SPR) sensing technique is an effective measurement scheme, but the ambient temperature and pH variations have a non-negligible impact. In this work, we developed a triple-probe SPR sensing system for detecting cDNA concentration, temperature, and pH. In order to satisfy the triple parameter measurements, we used a microstructured optical fiber as the sensing platform, silver and gold films as the excitation layer, and a MoS2 film as the modulation layer. First, we explore the modulation mechanism of SPR and the conditions for excitation of triple SPR and demonstrate that the carrier concentration is a crucial factor affecting the resonance wavelength. Then, the feasibility of the sensing system for triple-probing is theoretically analyzed. Finally, in the experiment, the optimal parameters of the sensor were determined, and the triple parameter detection was successfully realized. The experimental results show that the three probes can work independently, and the hybridized DNA probe can realize the selective detection of cDNA with a sensitivity of 0.249 nm/(nmol/l). The maximum sensitivity of the pH probe and the temperature probe are 51.5 nm/pH and 6.14 nm/°C. In addition, the experimental results show that the sensing probes have excellent reproducibility. This paper’s innovation is using the fiber optic SPR effect to achieve quantitative detection for cDNA, temperature detection, and pH detection. Therefore, the sensor has a promising future in early diagnosis and biosensing.
{"title":"Cascade amplification-based triple probe biosensor for high-precision DNA hybridization detection of lung cancer gene","authors":"Zhiyong Yin, Xili Jing, Shuguang Li","doi":"10.1063/5.0228760","DOIUrl":"https://doi.org/10.1063/5.0228760","url":null,"abstract":"As an essential biomarker for diagnosing and treating various diseases, low-cost, quantitative detection methods for complementary DNA (cDNA) have received much attention. The surface plasmon resonance (SPR) sensing technique is an effective measurement scheme, but the ambient temperature and pH variations have a non-negligible impact. In this work, we developed a triple-probe SPR sensing system for detecting cDNA concentration, temperature, and pH. In order to satisfy the triple parameter measurements, we used a microstructured optical fiber as the sensing platform, silver and gold films as the excitation layer, and a MoS2 film as the modulation layer. First, we explore the modulation mechanism of SPR and the conditions for excitation of triple SPR and demonstrate that the carrier concentration is a crucial factor affecting the resonance wavelength. Then, the feasibility of the sensing system for triple-probing is theoretically analyzed. Finally, in the experiment, the optimal parameters of the sensor were determined, and the triple parameter detection was successfully realized. The experimental results show that the three probes can work independently, and the hybridized DNA probe can realize the selective detection of cDNA with a sensitivity of 0.249 nm/(nmol/l). The maximum sensitivity of the pH probe and the temperature probe are 51.5 nm/pH and 6.14 nm/°C. In addition, the experimental results show that the sensing probes have excellent reproducibility. This paper’s innovation is using the fiber optic SPR effect to achieve quantitative detection for cDNA, temperature detection, and pH detection. Therefore, the sensor has a promising future in early diagnosis and biosensing.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"35 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhikai Zhu, Hyunmo Yang, Hongqiu Lei, Yusi Miao, George Philipopoulos, Melody Doosty, David Mukai, Yuchen Song, Jangwoen Lee, Sari Mahon, Matthew Brenner, Livia Veress, Carl White, Woonggyu Jung, Zhongping Chen
Chlorine exposure can cause severe airway injuries. While the acute effects of chlorine inhalation are well-documented, the structural changes resulting from the post-acute, high-level chlorine exposure remain less understood. Airway sloughing is one of the standards for doctors to evaluate the lung function. Here, we report the application of a high-resolution swept-source optical coherence tomography system to investigate the progression of injury based on airway sloughing evaluation in a chlorine inhalation rabbit model. This system employs a 1.2 mm diameter flexible fiberoptic endoscopic probe via an endotracheal tube to capture in vivo large airway anatomical changes before and as early as 30 min after acute chlorine exposure. We conducted an animal study using New Zealand white rabbits exposed to acute chlorine gas (800 ppm, 6 min) during ventilation and monitored them using optical coherence tomography (OCT) for 6 h. To measure the volume of airway sloughing induced by chlorine gas, we utilized deep learning for the segmentation task on OCT images. The results showed that the volume of chlorine induced epithelial sloughing on rabbit tracheal walls initially increased, peaked around 30 min, and then decreased. Furthermore, we utilized a spectral encoded interferometric microscopy system to study ex vivo airway cilia beating dynamics based on Doppler shift, aiding in elucidating how chlorine gas affects cilia beating function. Cilia movability and beating frequency were decreased because of the epithelium damage. This quantitative approach has the potential to enhance the diagnosis and monitoring of injuries from toxic gas inhalation and to evaluate the efficacy of antidote treatments for these injuries.
{"title":"Quantitative assessment of chlorine gas inhalation injury based on endoscopic OCT and spectral encoded interferometric microscope imaging with deep learning","authors":"Zhikai Zhu, Hyunmo Yang, Hongqiu Lei, Yusi Miao, George Philipopoulos, Melody Doosty, David Mukai, Yuchen Song, Jangwoen Lee, Sari Mahon, Matthew Brenner, Livia Veress, Carl White, Woonggyu Jung, Zhongping Chen","doi":"10.1063/5.0222153","DOIUrl":"https://doi.org/10.1063/5.0222153","url":null,"abstract":"Chlorine exposure can cause severe airway injuries. While the acute effects of chlorine inhalation are well-documented, the structural changes resulting from the post-acute, high-level chlorine exposure remain less understood. Airway sloughing is one of the standards for doctors to evaluate the lung function. Here, we report the application of a high-resolution swept-source optical coherence tomography system to investigate the progression of injury based on airway sloughing evaluation in a chlorine inhalation rabbit model. This system employs a 1.2 mm diameter flexible fiberoptic endoscopic probe via an endotracheal tube to capture in vivo large airway anatomical changes before and as early as 30 min after acute chlorine exposure. We conducted an animal study using New Zealand white rabbits exposed to acute chlorine gas (800 ppm, 6 min) during ventilation and monitored them using optical coherence tomography (OCT) for 6 h. To measure the volume of airway sloughing induced by chlorine gas, we utilized deep learning for the segmentation task on OCT images. The results showed that the volume of chlorine induced epithelial sloughing on rabbit tracheal walls initially increased, peaked around 30 min, and then decreased. Furthermore, we utilized a spectral encoded interferometric microscopy system to study ex vivo airway cilia beating dynamics based on Doppler shift, aiding in elucidating how chlorine gas affects cilia beating function. Cilia movability and beating frequency were decreased because of the epithelium damage. This quantitative approach has the potential to enhance the diagnosis and monitoring of injuries from toxic gas inhalation and to evaluate the efficacy of antidote treatments for these injuries.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"6 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rui Ma, Zijun Huang, Wei Ke, Xichen Wang, Peng Hao, X. Steve Yao, Xinlun Cai
We report a novel widely tunable Ka-band optoelectronic oscillator (OEO) realized by integrating a Mach–Zehnder modulator (MZM), a thermally-tunable add-drop micro-ring resonator (MRR), and a Mach–Zehnder interferometer (MZI) on the thin film lithium niobate platform, with the MZM and the MRR sequentially situated in one of the MZI arms. The MZM is for modulating the optical carrier, while the add-drop MRR is for selecting a single modulation sideband to beat with the unmodulated optical carrier from the other arm of the MZI, such that the OEO oscillation frequency is determined by the frequency spacing between the optical carrier and the selected modulation sideband, while the frequency tuning range is determined by the free spectral range of the MRR. By tuning the resonances of the add-drop MRR, the oscillation frequency can be tuned from 20 to 35 GHz, with the phase noises of −85 dBc/Hz @10 kHz and −116 dBc/Hz @100 kHz in the whole tuning range, which represent much higher oscillation frequency, much wider frequency tuning range, and lower phase noise than those of the photonic integrated OEOs realized with other material platforms reported previously.
{"title":"Widely tunable Ka-band optoelectronic oscillator integrated on thin film lithium niobate platform","authors":"Rui Ma, Zijun Huang, Wei Ke, Xichen Wang, Peng Hao, X. Steve Yao, Xinlun Cai","doi":"10.1063/5.0214107","DOIUrl":"https://doi.org/10.1063/5.0214107","url":null,"abstract":"We report a novel widely tunable Ka-band optoelectronic oscillator (OEO) realized by integrating a Mach–Zehnder modulator (MZM), a thermally-tunable add-drop micro-ring resonator (MRR), and a Mach–Zehnder interferometer (MZI) on the thin film lithium niobate platform, with the MZM and the MRR sequentially situated in one of the MZI arms. The MZM is for modulating the optical carrier, while the add-drop MRR is for selecting a single modulation sideband to beat with the unmodulated optical carrier from the other arm of the MZI, such that the OEO oscillation frequency is determined by the frequency spacing between the optical carrier and the selected modulation sideband, while the frequency tuning range is determined by the free spectral range of the MRR. By tuning the resonances of the add-drop MRR, the oscillation frequency can be tuned from 20 to 35 GHz, with the phase noises of −85 dBc/Hz @10 kHz and −116 dBc/Hz @100 kHz in the whole tuning range, which represent much higher oscillation frequency, much wider frequency tuning range, and lower phase noise than those of the photonic integrated OEOs realized with other material platforms reported previously.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"10 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Neves, Adimulya Kartiyasa, Shayantani Ghosh, Geoffrey Gaulier, Luca La Volpe, Jean-Pierre Wolf
In recent years, quantum Fourier transform infrared (QFTIR) spectroscopy has emerged as an alternative to conventional absorption spectroscopy in the mid-infrared region of the spectrum. By harnessing induced coherence and spectral correlations of photon pairs in a nonlinear Michelson interferometer, this technique offers promising potential for the practical detection of organic gases. However, little research was conducted to bring QFTIR spectrometers closer to domestic or in-field usage. In this work, we present the first use of a QFTIR spectrometer for open-path detection of multiple interfering organic gases in ambient air. We built a nonlinear Michelson interferometer with 1.7 m-long arms to increase the absorption length, coupled with analysis techniques from classical differential absorption spectroscopy used for gas-traces detection. We thus characterize our spectrometer’s sensitivity to acetone, methanol, and ethanol vapors and demonstrate the accurate identification of mixtures of these gases released in ambient air. We show this characteristic is preserved over time by performing a measurement overnight and tracking the evolution of different gases’ average concentrations. These results constitute the first use-case of a QFTIR spectrometer as a detector of organic gases and, thus, represent an important milestone toward the development of such detectors in practical situations.
{"title":"Open-path detection of organic vapors via quantum infrared spectroscopy","authors":"Simon Neves, Adimulya Kartiyasa, Shayantani Ghosh, Geoffrey Gaulier, Luca La Volpe, Jean-Pierre Wolf","doi":"10.1063/5.0220707","DOIUrl":"https://doi.org/10.1063/5.0220707","url":null,"abstract":"In recent years, quantum Fourier transform infrared (QFTIR) spectroscopy has emerged as an alternative to conventional absorption spectroscopy in the mid-infrared region of the spectrum. By harnessing induced coherence and spectral correlations of photon pairs in a nonlinear Michelson interferometer, this technique offers promising potential for the practical detection of organic gases. However, little research was conducted to bring QFTIR spectrometers closer to domestic or in-field usage. In this work, we present the first use of a QFTIR spectrometer for open-path detection of multiple interfering organic gases in ambient air. We built a nonlinear Michelson interferometer with 1.7 m-long arms to increase the absorption length, coupled with analysis techniques from classical differential absorption spectroscopy used for gas-traces detection. We thus characterize our spectrometer’s sensitivity to acetone, methanol, and ethanol vapors and demonstrate the accurate identification of mixtures of these gases released in ambient air. We show this characteristic is preserved over time by performing a measurement overnight and tracking the evolution of different gases’ average concentrations. These results constitute the first use-case of a QFTIR spectrometer as a detector of organic gases and, thus, represent an important milestone toward the development of such detectors in practical situations.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"58 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hippolyte Dupont, Matthieu Glasset, Pavel Loiko, Patrick Georges, Frédéric Druon
We report on the chaotic dynamics in a passively Q-switched 2.3-μm thulium laser operating on the 3H4 → 3H5 transition. The experiment exploits a Tm:LiYF4 crystal and various laser cavity configurations, involving an optional cascade laser on the 3F4 → 3H6 transition at 1.9 μm. The saturable absorber employed is Cr2+:ZnSe, which is exclusively saturated by the 2.3 μm laser. An analysis of the Q-switched dynamics shows a pronounced inclination of the laser operation toward the unstable and chaotic behavior. To understand the origins of this chaos, we monitor the population of the metastable 3F4 level via cascade laser operation at 1.9 μm, underlying this variable as an interesting parameter to survey chaotic instabilities.
{"title":"Chaotic dynamics in passively Q-switched Tm:LiYF4 laser operating at 2.3 μm on the 3H4 → 3H5 transition","authors":"Hippolyte Dupont, Matthieu Glasset, Pavel Loiko, Patrick Georges, Frédéric Druon","doi":"10.1063/5.0220220","DOIUrl":"https://doi.org/10.1063/5.0220220","url":null,"abstract":"We report on the chaotic dynamics in a passively Q-switched 2.3-μm thulium laser operating on the 3H4 → 3H5 transition. The experiment exploits a Tm:LiYF4 crystal and various laser cavity configurations, involving an optional cascade laser on the 3F4 → 3H6 transition at 1.9 μm. The saturable absorber employed is Cr2+:ZnSe, which is exclusively saturated by the 2.3 μm laser. An analysis of the Q-switched dynamics shows a pronounced inclination of the laser operation toward the unstable and chaotic behavior. To understand the origins of this chaos, we monitor the population of the metastable 3F4 level via cascade laser operation at 1.9 μm, underlying this variable as an interesting parameter to survey chaotic instabilities.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"3 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenhua Su, Dachao Zheng, Jiacheng Zhou, Qiushu Chen, Liwen Chen, Yuwei Yang, Yiyan Fei, Haijun Yao, Jiong Ma, Lan Mi
The precise determination of surgical margins is essential for the management of multifocal cutaneous cancers, including extramammary Paget’s disease. This study introduces a novel strategy for precise margin identification in such tumors, employing multichannel autofluorescence lifetime decay (MALD), fluorescence lifetime imaging microscopy (FLIM), and machine learning, including confidence learning algorithms. Using FLIM, 51 unstained frozen sections were analyzed, of which 13 (25%) sections, containing 5003 FLIM patches, were used for training the residual network model (ResNet–FLIM). The remaining 38 (75%) sections, including 16 918 patches, were retained for external validation. Application of confidence learning with deep learning reduced the reliance on extensive pathologist annotation. Refined labels obtained by ResNet–FLIM were then incorporated into a support vector machine (SVM) model, which utilized fiber-optic-based MALD data. Both models exhibited substantial agreement with the pathological assessments. Of the 35 MALD-measured tissue segments, six (17%) segments were selected as the training dataset, including 900 decay profiles. The remaining 29 segments (83%), including 2406 decay profiles, were reserved for external validation. The ResNet–FLIM model achieved 100% sensitivity and specificity. The SVM–MALD model demonstrated 94% sensitivity and 83% specificity. Notably, fiber-optic-MALD allows assessing 12 sites per patient and delivering predictions within 10 min. Variations in the necessary safe margin length were observed among patients, highlighting the necessity for patient-specific approaches to determine surgical margins. This innovative approach holds potential for wide clinical application, providing a rapid and accurate margin evaluation method that significantly reduces a pathologist’s workload and improves patient outcomes through personalized medicine.
{"title":"Rapid and precise multifocal cutaneous tumor margin assessment using fluorescence lifetime detection and machine learning","authors":"Wenhua Su, Dachao Zheng, Jiacheng Zhou, Qiushu Chen, Liwen Chen, Yuwei Yang, Yiyan Fei, Haijun Yao, Jiong Ma, Lan Mi","doi":"10.1063/5.0224181","DOIUrl":"https://doi.org/10.1063/5.0224181","url":null,"abstract":"The precise determination of surgical margins is essential for the management of multifocal cutaneous cancers, including extramammary Paget’s disease. This study introduces a novel strategy for precise margin identification in such tumors, employing multichannel autofluorescence lifetime decay (MALD), fluorescence lifetime imaging microscopy (FLIM), and machine learning, including confidence learning algorithms. Using FLIM, 51 unstained frozen sections were analyzed, of which 13 (25%) sections, containing 5003 FLIM patches, were used for training the residual network model (ResNet–FLIM). The remaining 38 (75%) sections, including 16 918 patches, were retained for external validation. Application of confidence learning with deep learning reduced the reliance on extensive pathologist annotation. Refined labels obtained by ResNet–FLIM were then incorporated into a support vector machine (SVM) model, which utilized fiber-optic-based MALD data. Both models exhibited substantial agreement with the pathological assessments. Of the 35 MALD-measured tissue segments, six (17%) segments were selected as the training dataset, including 900 decay profiles. The remaining 29 segments (83%), including 2406 decay profiles, were reserved for external validation. The ResNet–FLIM model achieved 100% sensitivity and specificity. The SVM–MALD model demonstrated 94% sensitivity and 83% specificity. Notably, fiber-optic-MALD allows assessing 12 sites per patient and delivering predictions within 10 min. Variations in the necessary safe margin length were observed among patients, highlighting the necessity for patient-specific approaches to determine surgical margins. This innovative approach holds potential for wide clinical application, providing a rapid and accurate margin evaluation method that significantly reduces a pathologist’s workload and improves patient outcomes through personalized medicine.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"72 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanjie Wang, Lin Zhao, Huiyue You, Huiling Wu, Qingliang Zhao, Xin Dong, Shengchuang Bai, Hongsen He, Jun Dong
Functional photoacoustic microscopy (PAM) requires laser sources with multiple wavelengths targeting abundant substances, where lipid and water are important components of living organisms. Here, we propose to use a single compact dual-wavelength passively Q-switched solid-state laser as the excitation source to directly achieve PA differentiation of water and lipid simultaneously. The main contribution of our work is to use the excitation difference under 1064- and 1176-nm lasers for mapping water and lipid in PAM, respectively. Meanwhile, the miniature structure (cavity size: ∼10 × 10 × 5.5 mm3) of the laser source is not only promising for portable applications but also benefits the PA-desired nanosecond (<2 ns) laser pulse establishment. Our technique is confirmed by efficient PA imaging of water and lipid in biological tissues at high spatial resolution and improved sensitivity. This laser provides a novel and low-cost imaging source for PAM to track changes in water and lipid distribution.
功能光声显微镜（PAM）需要针对丰富物质的多波长激光源，而脂质和水是生物体的重要组成部分。在此，我们建议使用单个紧凑型双波长被动 Q 开关固体激光器作为激发光源，直接同时实现水和脂质的 PA 分化。我们工作的主要贡献是利用 1064 和 1176 纳米激光下的激发差，分别绘制 PAM 中水和脂的分布图。同时，激光源的微型结构（腔体尺寸：∼10 × 10 × 5.5 mm3）不仅有利于便携式应用，还有利于 PA 所需的纳秒（<2 ns）激光脉冲建立。我们的技术得到了生物组织中水和脂质的高效 PA 成像的证实，空间分辨率高，灵敏度更高。这种激光为 PAM 跟踪水和脂质分布变化提供了一种新颖、低成本的成像源。
{"title":"Dual-wavelength, nanosecond, miniature Raman laser enables efficient photoacoustic differentiation of water and lipid","authors":"Hanjie Wang, Lin Zhao, Huiyue You, Huiling Wu, Qingliang Zhao, Xin Dong, Shengchuang Bai, Hongsen He, Jun Dong","doi":"10.1063/5.0216255","DOIUrl":"https://doi.org/10.1063/5.0216255","url":null,"abstract":"Functional photoacoustic microscopy (PAM) requires laser sources with multiple wavelengths targeting abundant substances, where lipid and water are important components of living organisms. Here, we propose to use a single compact dual-wavelength passively Q-switched solid-state laser as the excitation source to directly achieve PA differentiation of water and lipid simultaneously. The main contribution of our work is to use the excitation difference under 1064- and 1176-nm lasers for mapping water and lipid in PAM, respectively. Meanwhile, the miniature structure (cavity size: ∼10 × 10 × 5.5 mm3) of the laser source is not only promising for portable applications but also benefits the PA-desired nanosecond (&lt;2 ns) laser pulse establishment. Our technique is confirmed by efficient PA imaging of water and lipid in biological tissues at high spatial resolution and improved sensitivity. This laser provides a novel and low-cost imaging source for PAM to track changes in water and lipid distribution.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"50 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Ansari, G. F. Feutmba, J. P. George, H. Rijckaert, J. Beeckman, D. Van Thourhout
Piezoelectric optomechanical platforms provide a promising avenue for efficient signal transduction between microwave and optical domains. Lead zirconate titanate (PZT) thin film stands out as a compelling choice for building such a platform given its high piezoelectricity and optical transparency, enabling strong electro-optomechanical transduction. This work explores the application of such transduction to induce Fano resonance in a silicon photonics integrated circuit (PIC). Our methodology involves integrating a PZT thin film onto a silicon PIC and subsequently removing the SiO2 layer to suspend the silicon waveguide, allowing controlled mechanical vibrations. Fano resonances, characterized by their distinctive asymmetric line shape, were observed at frequencies up to 6.7 GHz with an extinction ratio of 21 dB. A high extinction ratio of 41 dB was achieved at the lower resonance frequency of 223 MHz. Our results demonstrate the potential of piezoelectric thin film integration for the generation of Fano resonances on passive photonic platforms such as Si, paving the way for highly sensitive, compact, and power-efficient devices relevant to a wide range of applications.
{"title":"Piezoelectrically driven Fano resonance in silicon photonics","authors":"I. Ansari, G. F. Feutmba, J. P. George, H. Rijckaert, J. Beeckman, D. Van Thourhout","doi":"10.1063/5.0207482","DOIUrl":"https://doi.org/10.1063/5.0207482","url":null,"abstract":"Piezoelectric optomechanical platforms provide a promising avenue for efficient signal transduction between microwave and optical domains. Lead zirconate titanate (PZT) thin film stands out as a compelling choice for building such a platform given its high piezoelectricity and optical transparency, enabling strong electro-optomechanical transduction. This work explores the application of such transduction to induce Fano resonance in a silicon photonics integrated circuit (PIC). Our methodology involves integrating a PZT thin film onto a silicon PIC and subsequently removing the SiO2 layer to suspend the silicon waveguide, allowing controlled mechanical vibrations. Fano resonances, characterized by their distinctive asymmetric line shape, were observed at frequencies up to 6.7 GHz with an extinction ratio of 21 dB. A high extinction ratio of 41 dB was achieved at the lower resonance frequency of 223 MHz. Our results demonstrate the potential of piezoelectric thin film integration for the generation of Fano resonances on passive photonic platforms such as Si, paving the way for highly sensitive, compact, and power-efficient devices relevant to a wide range of applications.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"35 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fraser T. Watt, Vivek Muthurangu, Jennifer Steeden, Eleanor C. Mackle, Adrien E. Desjardins, Edward Z. Zhang, Paul C. Beard, Erwin J. Alles
Optical ultrasound (OpUS) imaging is an ultrasound modality that utilizes fiber-optic ultrasound sources and detectors to perform pulse-echo ultrasound imaging. These probes can be constructed entirely from glass optical fibers and plastic components, and as such, these devices have been predicted to be compatible with computed tomography (CT) and magnetic resonance imaging (MRI), modalities that use intense electromagnetic fields for imaging. However, to date, this compatibility has not been demonstrated. In this work, a free-hand OpUS imaging system was developed specifically to investigate the compatibility of OpUS systems with CT and MRI imaging systems. The OpUS imaging platform discussed in this work was used to perform real-time OpUS imaging under (separately) concurrent CT and MRI. CT and MRI imaging of the OpUS probe was used to determine if the probe itself would induce artifacts in the CT and MRI imaging, and ultrasound resolution targets and background measurements were used to assess any impact of CT and MRI on the OpUS signal fidelity. These measurements demonstrate that there was negligible interaction between the OpUS system and both the CT and MRI systems, and to further demonstrate this capability, concurrent OpUS-CT and OpUS-MRI imaging was conducted of a tissue-mimicking phantom and a dynamic motion phantom. This work presents a comprehensive demonstration of an OpUS imaging system operating alongside CT and MRI, which opens up new applications of ultrasound imaging in electromagnetically challenging settings.
光学超声（OpUS）成像是一种利用光纤超声源和探测器进行脉冲回波超声成像的超声模式。这些探头可完全由玻璃光纤和塑料部件制成，因此，人们预测这些设备可与使用强电磁场成像的计算机断层扫描（CT）和磁共振成像（MRI）兼容。然而，迄今为止，这种兼容性尚未得到证实。在这项工作中，我们专门开发了一种自由手持式 OpUS 成像系统，以研究 OpUS 系统与 CT 和 MRI 成像系统的兼容性。这项工作中讨论的 OpUS 成像平台用于在（单独）同时进行的 CT 和 MRI 下进行实时 OpUS 成像。OpUS探头的CT和MRI成像用于确定探头本身是否会在CT和MRI成像中产生伪影，超声分辨率目标和背景测量用于评估CT和MRI对OpUS信号保真度的影响。这些测量结果表明，OpUS 系统与 CT 和 MRI 系统之间的相互作用可以忽略不计，为了进一步证明这种能力，对一个组织模拟模型和一个动态运动模型同时进行了 OpUS-CT 和 OpUS-MRI 成像。这项工作全面展示了与 CT 和 MRI 同时运行的 OpUS 成像系统，开辟了超声成像在电磁挑战环境中的新应用。
{"title":"Multimodal optical ultrasound imaging: Real-time imaging under concurrent CT or MRI","authors":"Fraser T. Watt, Vivek Muthurangu, Jennifer Steeden, Eleanor C. Mackle, Adrien E. Desjardins, Edward Z. Zhang, Paul C. Beard, Erwin J. Alles","doi":"10.1063/5.0225554","DOIUrl":"https://doi.org/10.1063/5.0225554","url":null,"abstract":"Optical ultrasound (OpUS) imaging is an ultrasound modality that utilizes fiber-optic ultrasound sources and detectors to perform pulse-echo ultrasound imaging. These probes can be constructed entirely from glass optical fibers and plastic components, and as such, these devices have been predicted to be compatible with computed tomography (CT) and magnetic resonance imaging (MRI), modalities that use intense electromagnetic fields for imaging. However, to date, this compatibility has not been demonstrated. In this work, a free-hand OpUS imaging system was developed specifically to investigate the compatibility of OpUS systems with CT and MRI imaging systems. The OpUS imaging platform discussed in this work was used to perform real-time OpUS imaging under (separately) concurrent CT and MRI. CT and MRI imaging of the OpUS probe was used to determine if the probe itself would induce artifacts in the CT and MRI imaging, and ultrasound resolution targets and background measurements were used to assess any impact of CT and MRI on the OpUS signal fidelity. These measurements demonstrate that there was negligible interaction between the OpUS system and both the CT and MRI systems, and to further demonstrate this capability, concurrent OpUS-CT and OpUS-MRI imaging was conducted of a tissue-mimicking phantom and a dynamic motion phantom. This work presents a comprehensive demonstration of an OpUS imaging system operating alongside CT and MRI, which opens up new applications of ultrasound imaging in electromagnetically challenging settings.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"144 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mid-infrared (MIR) photonic integration is desirable in the development of MIR spectroscopy and “lab-on-a-chip” sensing. The germanium-on-silicon (GOS) platform offers a promising solution for MIR photonic integration, extending the operational wavelength to a longer band by eliminating the light-absorbing buried oxide layer. However, MIR photodetectors on the GOS platform remain undeveloped due to the challenging heterogeneous integration of active materials on silicon and inadequate light absorption in the photodetection region. Here, we demonstrate a photo-thermoelectric graphene photodetector on the GOS platform, taking advantage of zero-bias operation and easy heterogeneous integration of graphene. By employing split-gate architecture and plasmonic enhancement to strengthen the light-graphene interaction, we achieve a responsivity of 1.97 V W−1 and noise equivalent power of 2.8 nW Hz−1/2 at the wavelength of 3.7 µm. This work enables waveguide-integrated MIR photodetection on the GOS platform for the first time, and it holds great potential for on-chip MIR sensing and imaging applications.
{"title":"Mid-infrared waveguide-integrated and photo-thermoelectric graphene photodetector based on germanium-on-silicon platform","authors":"Hongjun Cai, Changming Yang, Yuheng Liu, Xinliang Zhang, Yi Zou, Yu Yu","doi":"10.1063/5.0218976","DOIUrl":"https://doi.org/10.1063/5.0218976","url":null,"abstract":"Mid-infrared (MIR) photonic integration is desirable in the development of MIR spectroscopy and “lab-on-a-chip” sensing. The germanium-on-silicon (GOS) platform offers a promising solution for MIR photonic integration, extending the operational wavelength to a longer band by eliminating the light-absorbing buried oxide layer. However, MIR photodetectors on the GOS platform remain undeveloped due to the challenging heterogeneous integration of active materials on silicon and inadequate light absorption in the photodetection region. Here, we demonstrate a photo-thermoelectric graphene photodetector on the GOS platform, taking advantage of zero-bias operation and easy heterogeneous integration of graphene. By employing split-gate architecture and plasmonic enhancement to strengthen the light-graphene interaction, we achieve a responsivity of 1.97 V W−1 and noise equivalent power of 2.8 nW Hz−1/2 at the wavelength of 3.7 µm. This work enables waveguide-integrated MIR photodetection on the GOS platform for the first time, and it holds great potential for on-chip MIR sensing and imaging applications.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"14 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142199472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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