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Analysis of norepinephrine-regulated cerebral lymphatic drainage by the second near-infrared region in vivo imaging 通过第二近红外区域活体成像分析去甲肾上腺素调控的脑淋巴引流
IF 5.6 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-12 DOI: 10.1063/5.0205571
Xi Li, Tianhao Yang, Zhongyang Zhang, Shengnan Wu, Zhen Yuan, Feifan Zhou
The cerebral lymphatic drainage plays an important role in the occurrence and development of central nervous system diseases. Recent studies have shown that cerebral lymphatic drainage is regulated by circadian rhythm and anesthesia state; however, the regulating mechanism is still unclear. In this study, we used the second near-infrared region in vivo imaging to explore the regulation of cerebral lymphatic drainage in mice at different states. At first, by injection of a tracer at different times, we confirmed that the drainage of the meningeal lymphatic system was the fastest at zeitgeber time 2, while the internal flow of the glymphatic system was the slowest. Under anesthesia with isoflurane, administration of dexmedetomidine, an anesthetic that inhibits norepinephrine (NE) release, enabled mice to enter the stage of non-rapid eye movement sleep, at which time the influx of the glymphatic system increased, the efflux of the meningeal lymphatic system decreased, and the clearance rate of the brain parenchyma decreased. However, following the exogenous NE supplement, mice quickly changed from a non-rapid eye movement stage into an awake state with the meningeal lymphatic drainage retrieval. The results showed whether the drainage of the glymphatic system and meningeal lymphatic vessels, or parenchymal clearance, has made rapid adjustments based on sleep status that is regulated by NE. This study reveals that the NE-regulated sleep–wake cycle is a powerful regulator of cerebral lymphatic drainage and provides a potential therapeutic target for related central nervous system diseases.
脑淋巴引流在中枢神经系统疾病的发生和发展中起着重要作用。近年来的研究表明,脑淋巴引流受昼夜节律和麻醉状态的调控,但其调控机制尚不清楚。在本研究中,我们利用第二近红外区域活体成像技术探讨了不同状态下小鼠脑淋巴引流的调控。首先,通过在不同时间注射示踪剂,我们证实脑膜淋巴系统的引流在zeitgeber时间2时最快,而甘淋巴系统的内流最慢。在异氟醚麻醉下,给小鼠注射右美托咪定(一种抑制去甲肾上腺素(NE)释放的麻醉剂)可使小鼠进入非快速眼动睡眠阶段,此时甘液系统的流入量增加,脑膜淋巴系统的流出量减少,脑实质的清除率降低。然而,在补充外源性 NE 后,小鼠很快从眼球非快速运动阶段转入清醒状态,脑膜淋巴引流恢复。研究结果表明,甘液系统和脑膜淋巴管的引流或实质清除是否会根据睡眠状态进行快速调整,这是受 NE 调节的。这项研究揭示了受 NE 调节的睡眠-觉醒周期是大脑淋巴引流的一个强有力的调节器,并为相关的中枢神经系统疾病提供了一个潜在的治疗靶点。
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引用次数: 0
Femtosecond laser-induced dewetting of sub-10-nm nanostructures on silicon in ambient air 环境空气中飞秒激光诱导的硅上 10 纳米以下结构的脱水现象
IF 5.6 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-10 DOI: 10.1063/5.0205219
Hao Luo, Xiaoduo Wang, Yangdong Wen, Ye Qiu, Lianqing Liu, Haibo Yu
To realize nanoscale manufacturing based on laser direct writing technology, objective lenses with high numerical apertures immersed in water or oil are necessary. The use of liquid medium restricts its application in semiconductors. Achieving nanoscale features on silicon by laser direct writing in a low refractive index medium has been a challenge. In this work, a microsphere assisted femtosecond laser far-field induced dewetting approach is proposed. A reduction in the full-width at half-maximum of the focused light spot is realized by modulating tightly focused light through microspheres and achieving a minimum feature size of 9 nm on silicon in ambient air with energy smaller than the ablation threshold. Theoretical analysis and numerical simulation of laser processing are performed based on a two-temperature model. Furthermore, we explored the potential of femtosecond laser-induced dewetting in nanolithography and demonstrated its ability to achieve an arbitrary structure on silicon. Our work enables laser-based far-field sub-10-nm feature etching on a large-scale, providing a novel avenue for nanoscale silicon manufacturing.
要在激光直写技术的基础上实现纳米级制造,必须使用浸没在水或油中的高数值孔径物镜。液体介质的使用限制了其在半导体领域的应用。在低折射率介质中通过激光直写技术在硅上实现纳米级特征一直是一个挑战。在这项工作中,提出了一种微球辅助飞秒激光远场诱导露斑方法。通过调制穿过微球的紧聚焦光,实现了聚焦光斑半最大全宽的减小,并在环境空气中以小于烧蚀阈值的能量在硅上实现了 9 纳米的最小特征尺寸。我们基于双温模型对激光加工进行了理论分析和数值模拟。此外,我们还探索了飞秒激光诱导露斑在纳米光刻技术中的潜力,并证明了其在硅上实现任意结构的能力。我们的工作实现了大规模基于激光的远场 10 纳米以下特征刻蚀,为纳米级硅制造提供了一条新途径。
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引用次数: 0
Hot electron effect in high-order harmonic generation from graphene driven by elliptically polarized light 椭圆偏振光驱动石墨烯产生高阶谐波时的热电子效应
IF 5.6 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-03 DOI: 10.1063/5.0212022
Kotaro Nakagawa, Wenwen Mao, Shunsuke A. Sato, Hiroki Ago, Angel Rubio, Yoshihiko Kanemitsu, Hideki Hirori
We studied high-order harmonic generation (HHG) in graphene driven by either linearly or elliptically polarized mid-infrared (MIR) light, and we additionally applied terahertz (THz) pulses to modulate the electron distribution in graphene. The high-harmonic spectrum obtained using linearly polarized MIR light contains only odd-order harmonics. We found that the intensities of the fifth- and seventh-order harmonics are reduced by the modulation with the THz pulses. In addition, we found that the THz-induced reduction of the seventh-order harmonic driven by elliptically polarized MIR light (at ellipticity ε = 0.3) is larger than that of seventh-order harmonic driven by linearly polarized MIR light (ε = 0). The observed behavior can be reproduced by theoretical calculations that consider different electron temperatures (caused by the THz pulses). Furthermore, the observed stronger suppression of HHG driven by elliptically polarized light reveals the following: in the case of elliptically polarized light, the generation of harmonics via interband transitions to conduction-band states that are closer to the Dirac point is more important than in the case of linearly polarized light. In other words, the quantum pathways via interband transitions to low-energy states are the origin of the enhancement of HHG that can be achieved in graphene by using elliptically polarized light.
我们研究了线性偏振或椭圆偏振中红外光(MIR)驱动石墨烯产生的高次谐波(HHG),并额外应用太赫兹(THz)脉冲调制石墨烯中的电子分布。使用线性偏振中红外光获得的高次谐波频谱只包含奇阶谐波。我们发现,在太赫兹脉冲的调制下,五阶和七阶谐波的强度降低了。此外,我们还发现太赫兹对椭圆偏振 MIR 光(椭圆度 ε = 0.3 时)驱动的七阶谐波的抑制作用大于线性偏振 MIR 光(ε = 0)驱动的七阶谐波。理论计算考虑了不同的电子温度(由太赫兹脉冲引起),可以再现观察到的行为。此外,观察到的椭圆偏振光对 HHG 的更强抑制揭示了以下几点:与线性偏振光相比,在椭圆偏振光情况下,通过带间跃迁到更接近狄拉克点的导带态来产生谐波更为重要。换句话说,通过带间跃迁到低能态的量子途径是使用椭圆偏振光在石墨烯中增强 HHG 的起源。
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引用次数: 0
Broadband color routing with a single element nanoantenna for communication bands 利用单元素纳米天线为通信波段提供宽带彩色路由功能
IF 5.6 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-02 DOI: 10.1063/5.0206274
Xianghua Liu, Ang Li, Chenyang Liu, Nengyang Zhao, Jiahao Peng, Fengyuan Gan, Xinrui Lei, Ruxue Wang, Aimin Wu
Spectral routing techniques have attracted plenty of research attention for the past decades, as they enable light manipulation in both the frequency domain and the spatial domain, which is crucial for applications in on-chip spectroscopy, optical switching, and modern communications. Here, we demonstrate an ultra-compact asymmetric nanoplasmonic router for communication bands that routes O and C bands to opposite positions. The nanorouter consists of two uneven grooves that create bidirectional scattered optical fields, utilizing the interference between different optical modes inside the grooves. A broadband spectrum exceeding 100 nm and a maximum extinction ratio of 31 dB are achieved, providing new opportunities for nanophotonic color routing solutions and extensions to other areas such as imaging sensors and spectral measurements.
过去几十年来,光谱路由技术吸引了大量研究人员的关注,因为它们可以在频域和空间域对光进行操纵,这对于片上光谱学、光开关和现代通信中的应用至关重要。在这里,我们展示了一种用于通信波段的超紧凑非对称纳米光电路由器,它能将 O 波段和 C 波段路由到相反的位置。该纳米路由器由两个凹凸不平的凹槽组成,利用凹槽内不同光学模式之间的干涉,产生双向散射光场。实现了超过 100 nm 的宽带光谱和 31 dB 的最大消光比,为纳米光子色彩路由解决方案提供了新的机遇,并扩展到成像传感器和光谱测量等其他领域。
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引用次数: 0
High-Q magnetic toroidal dipole resonance in all-dielectric metasurfaces 全介质元表面中的高 Q 磁环偶极共振
IF 5.6 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-02 DOI: 10.1063/5.0208936
Ying Zhang, Lulu Wang, Haoxuan He, Hong Duan, Jing Huang, Chenggui Gao, Shaojun You, Lujun Huang, Andrey E. Miroshnichenko, Chaobiao Zhou
High quality (Q) factor toroidal dipole (TD) resonances have played an increasingly important role in enhancing light–matter interactions. Interestingly, TDs share a similar far-field distribution as the conventional electric/magnetic dipoles but have distinct near-field profiles from them. While most reported works focused on the electric TD, magnetic TDs (MTDs), particularly high-Q MTD, have not been fully explored yet. Here, we successfully realized a high-Q MTD by effectively harnessing the ultrahigh Q-factor guided mode resonances supported in an all-dielectric metasurface, that is, changing the interspacing between silicon nanobar dimers. Other salient properties include the stable resonance wavelength but a precisely tailored Q-factor by interspacing distance. A multipole decomposition analysis indicates that this mode is dominated by the MTD, where the electric fields are mainly confined within the dielectric nanostructures, while the induced magnetic dipole loops are connected head-to-tail. Finally, we experimentally demonstrated such high-Q MTD resonance by fabricating a series of silicon metasurfaces and measuring their transmission spectra. The MTD resonance is characterized by a sharp Fano resonance in the transmission spectrum. The maximum measured Q-factor is up to 5079. Our results provide useful guidance for realizing high-Q MTD and may find exciting applications in boosting light–matter interactions.
高质量(Q)因子环状偶极子(TD)共振在增强光物质相互作用方面发挥着越来越重要的作用。有趣的是,TD 与传统的电偶极/磁偶极有着相似的远场分布,但却有着不同的近场分布。虽然大多数报道都集中在电TD上,但磁TD(MTD),尤其是高Q MTD,尚未得到充分探索。在这里,我们通过有效利用全介质元表面支持的超高 Q 因子导模共振,即改变硅纳米棒二聚体之间的间隔,成功实现了高 Q 值 MTD。其他突出特性包括共振波长稳定,但Q因子可通过间隔距离精确定制。多极分解分析表明,该模式由 MTD 主导,其中电场主要局限在介电纳米结构内,而诱导磁偶极环则头尾相连。最后,我们通过制作一系列硅元表面并测量其透射光谱,在实验中证明了这种高 Q 值 MTD 共振。MTD 共振的特点是透射光谱中存在尖锐的法诺共振。测得的最大 Q 因子高达 5079。我们的研究结果为实现高 Q 值 MTD 提供了有用的指导,并可能在促进光物质相互作用方面找到令人兴奋的应用。
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引用次数: 0
Quantum states generation and manipulation in a programmable silicon-photonic four-qubit system with high-fidelity and purity 高保真、高纯度可编程硅光子四量子比特系统中量子态的产生与操纵
IF 5.4 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-01 DOI: 10.1063/5.0207714
Jong-Moo Lee, Jiho Park, Jeongho Bang, Young-Ik Sohn, Alessio Baldazzi, M. Sanna, S. Azzini, Lorenzo Pavesi
We present a programmable silicon photonic four-qubit integrated circuit for the generation and manipulation of diverse quantum states. The silicon photonic chip integrates photon-pair sources, pump-reducing filters, wavelength-division-multiplexing filters, Mach–Zehnder interferometer switches, and single-qubit arbitrary gates, enabling versatile state preparation and tomography. We measure Hong–Ou–Mandel interference with an impressive 98% visibility using four-photon coincidence, laying the foundation for high-purity qubits. Our analysis involves estimating the fidelity and purity of distinct quantum states through maximum-likelihood estimation applied to tomographic measurements. In our experimental results, we showcase the following achievements: a heralded single qubit achieving 98.2% fidelity and 98.3% purity, a Bell state reaching 95.2% fidelity and 94.8% purity, and a four-qubit system with two simultaneous Bell states exhibiting 87.4% fidelity and 84.6% purity. Finally, a four-qubit Greenberger–Horne–Zeilinger (GHZ) state demonstrates 85.4% fidelity and 81.7% purity. In addition, we certify the entanglement of the four-photon GHZ state through Bell’s inequality violations and a negative entanglement witness.
我们提出了一种可编程硅光子四量子比特集成电路,用于产生和操纵各种量子态。硅光子芯片集成了光子对源、泵浦还原滤波器、波分复用滤波器、马赫-泽恩德干涉仪开关和单量子比特任意门,实现了多功能状态制备和层析成像。我们利用四光子巧合测量了能见度高达 98% 的洪欧-曼德尔干涉,为高纯度量子比特奠定了基础。我们的分析包括通过应用于层析测量的最大似然估计来估计不同量子态的保真度和纯度。在我们的实验结果中,我们展示了以下成就:一个预示性的单量子比特达到了 98.2% 的保真度和 98.3% 的纯度,一个贝尔态达到了 95.2% 的保真度和 94.8% 的纯度,一个同时具有两个贝尔态的四量子比特系统展示了 87.4% 的保真度和 84.6% 的纯度。最后,一个四量子比特格林伯格-霍恩-蔡林格(GHZ)态显示出 85.4% 的保真度和 81.7% 的纯度。此外,我们还通过违反贝尔不等式和负纠缠见证证明了四光子 GHZ 状态的纠缠性。
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引用次数: 0
Erratum: “Frequency-mode-stable regenerative amplification at terahertz burst rates” [APL Photonics 9, 036116 (2024)] 勘误:"太赫兹猝发率下的频模稳定再生放大"[APL Photonics 9, 036116 (2024)]
IF 5.4 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-01 DOI: 10.1063/5.0225705
V. Stummer, T. Flöry, M. Schneller, E. Kaksis, M. Zeiler, A. Pugžlys, A. Baltuška
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引用次数: 0
Space–time characterization of ultrashort laser pulses: A perspective 超短激光脉冲的时空特征:透视
IF 5.4 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-01 DOI: 10.1063/5.0219447
Benjamín Alonso, A. Döpp, Spencer W. Jolly
The characterization of ultrashort laser pulses has significantly advanced beyond the standard spatial and temporal diagnostics to now include sophisticated spatio-temporal measurement techniques. In this perspective, we provide an overview of the current state of space–time characterization, discussing the theoretical foundations of ultrashort laser pulses, the various measurement techniques and their design trade-offs, and the challenges and opportunities for future development. We explore the extension of these techniques to different wavelength regimes and delve into the unique challenges posed by the characterization of polarization-structured beams. The potential for data-driven analysis to enhance the information extracted from the measurements is highlighted, along with the need for direct measurement of previously inaccessible field components, such as the longitudinal electric field in tightly focused beams. As these diagnostic tools continue to evolve, we anticipate a future where the intricate space–time structure of light can be analyzed on a routine basis, opening up new frontiers in ultrafast science and technology.
超短激光脉冲的表征技术已经大大超越了标准的空间和时间诊断技术,现在包括了复杂的时空测量技术。在本视角中,我们概述了时空表征的现状,讨论了超短激光脉冲的理论基础、各种测量技术及其设计权衡,以及未来发展的挑战和机遇。我们探讨了如何将这些技术扩展到不同的波长范围,并深入探讨了偏振结构光束表征所带来的独特挑战。我们强调了数据驱动分析的潜力,以增强从测量中提取的信息,以及直接测量以前无法获得的场分量的必要性,例如紧聚焦光束中的纵向电场。随着这些诊断工具的不断发展,我们预计未来可以对光的复杂时空结构进行常规分析,从而开辟超快科学与技术的新领域。
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引用次数: 0
Optically controllable deformation and phase change in VO2/Si3N4/Au hybrid nanostructures with polarization selectivity 具有偏振选择性的 VO2/Si3N4/Au 混合纳米结构中的光可控形变和相变
IF 5.6 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-01 DOI: 10.1063/5.0213410
Xiaochen Zhang, Yuan Li, Weikang Dong, Qinghua Liang, Haozhe Sun, Yang Wang, Xiaowei Li, Lan Jiang, Xinping Zhang, He Ma, Jiafang Li
Optically spatial displacement and material modification hold great potential for the appealing applications in nanofabrication and reconfiguration of functional optical devices. Here, we propose and demonstrate a scheme to achieve simultaneous deformation and phase change in vanadium dioxide (VO2)/Si3N4/Au hybrid nanostructures by laser stimuli. Low triggering threshold and significant deformation characteristics of VO2, based on controllable phase transition, are demonstrated in microscale cantilevers. The plasmonic properties of the nanostructure array are further utilized to achieve a polarization-selective dynamic response. The persistence of deformation and dynamical optical modulation are further demonstrated. Such high-precision fabrication methods and non-contact reconfiguration methods are useful for future applications in dynamic optical manipulation.
光学空间位移和材料改性在纳米制造和功能光学器件的重新配置方面具有巨大的应用潜力。在此,我们提出并演示了一种通过激光刺激实现二氧化钒(VO2)/Si3N4/金混合纳米结构同时变形和相变的方案。在微尺度悬臂中展示了基于可控相变的低触发阈值和二氧化钒的显著变形特性。纳米结构阵列的等离子特性被进一步用于实现极化选择性动态响应。变形的持久性和动态光学调制得到了进一步证实。这种高精度制造方法和非接触式重新配置方法对未来动态光学操纵的应用非常有用。
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引用次数: 0
2 W monolithic fiber laser at 3.8 µm 2 W 单片光纤激光器,波长 3.8 µm
IF 5.6 1区 物理与天体物理 Q1 OPTICS Pub Date : 2024-07-01 DOI: 10.1063/5.0212455
M. Lemieux-Tanguay, T. Boilard, P. Paradis, R. Vallée, M. Bernier
We report a dual-wavelength-pumped all-fiber continuous-wave laser operating at the extended wavelength of 3.79 µm that reaches a record output power of 2.0 W. This represents, to the best of our knowledge, the highest output power reported at the longest spectral range for a fiber laser. The laser cavity, made of a heavily erbium-doped fluoride fiber and bounded by two photo-inscribed fiber Bragg gratings, reaches a slope efficiency of 46.5% with respect to the absorbed 1976 nm pump power. The system exhibits an absorption dependency of the 1976 nm pump on the launched 976 nm pump and a quenching behavior dependency on the output coupler reflectivity. The all-fiber design of the cavity allows significant power scaling of the laser and ensures its long-term stability.
据我们所知,这是目前所报道的光纤激光器在最长光谱范围内的最高输出功率。激光腔由重度掺铒氟化物光纤制成,以两个光刻光纤布拉格光栅为边界,相对于吸收的1976 nm泵浦功率,斜率效率达到46.5%。该系统显示出 1976 纳米泵浦对发射的 976 纳米泵浦的吸收依赖性,以及对输出耦合器反射率的淬火行为依赖性。腔体的全光纤设计使激光器的功率扩展显著,并确保了其长期稳定性。
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引用次数: 0
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APL Photonics
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