Maria Mielnik-Błaszczak, Dorota Krawczyk, Elzbieta Pels, Zbigniew Opałczyński, Wojciech Kisiel
The study covered 106 eight-year-old children attending different schools in Lublin that do not provide dental care. The study evaluated decay frequency, DEF value and its components D, E, F, def value and its components d, e, f as well as treatment index for deciduous and permanent teeth. Additionally, it assessed the needs for orthodontic and prosthetic provisions connected with premature loss of deciduous teeth. The study found low treatment index, especially for deciduous teeth. Premature loss of deciduous teeth is an indication for prosthetic provision in the form of space retainers or partial dentures. Without prompt treatment different acquired facio-occlusal defects may develop.
{"title":"Evaluation of stomatological needs of 8-year-old children connected with premature loss of deciduous teeth.","authors":"Maria Mielnik-Błaszczak, Dorota Krawczyk, Elzbieta Pels, Zbigniew Opałczyński, Wojciech Kisiel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study covered 106 eight-year-old children attending different schools in Lublin that do not provide dental care. The study evaluated decay frequency, DEF value and its components D, E, F, def value and its components d, e, f as well as treatment index for deciduous and permanent teeth. Additionally, it assessed the needs for orthodontic and prosthetic provisions connected with premature loss of deciduous teeth. The study found low treatment index, especially for deciduous teeth. Premature loss of deciduous teeth is an indication for prosthetic provision in the form of space retainers or partial dentures. Without prompt treatment different acquired facio-occlusal defects may develop.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 1","pages":"80-3"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24996459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomasz Saran, Wojciech Sodolski, Katarzyna Sodolska, Wit Cezary Danilkiewicz, Janusz Schabowski
Clinical and experimental studies have shown that renal and cardiovascular effects of most selective COX-2 inhibitors (rofecoxib, celecoxib) are similar to other traditional NSAIDs (dual COX inhibitors). In these study the effect of nimesulide--preferential COX-2 inhibitor, administration on 24-hour blood pressure profile was investigated in 40 adult individuals on antihypertensive therapy with pain states caused by osteoartritis. Nimesulide was administered orally, twice a day at the conventional dose of 0.1 g for five days. In the next (or previous) 5 days the same patients were administered with ketoprofen at the dose of 0.05 g three times a day. On the last day of the NSAID administration period, 24-hour blood pressure monitoring was performed. Our results indicate no difference between nimesulide and ketoprofen effects on mean blood pressure values during antihypertensive therapy.
{"title":"Effect of nimesulide-a preferential COX-2 inhibitor on arterial blood pressure, compared to ketoprofen.","authors":"Tomasz Saran, Wojciech Sodolski, Katarzyna Sodolska, Wit Cezary Danilkiewicz, Janusz Schabowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical and experimental studies have shown that renal and cardiovascular effects of most selective COX-2 inhibitors (rofecoxib, celecoxib) are similar to other traditional NSAIDs (dual COX inhibitors). In these study the effect of nimesulide--preferential COX-2 inhibitor, administration on 24-hour blood pressure profile was investigated in 40 adult individuals on antihypertensive therapy with pain states caused by osteoartritis. Nimesulide was administered orally, twice a day at the conventional dose of 0.1 g for five days. In the next (or previous) 5 days the same patients were administered with ketoprofen at the dose of 0.05 g three times a day. On the last day of the NSAID administration period, 24-hour blood pressure monitoring was performed. Our results indicate no difference between nimesulide and ketoprofen effects on mean blood pressure values during antihypertensive therapy.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 2","pages":"261-7"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24996470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agnieszka Magdalena Grzebalska, Maria Majdan, Ewa Bober, Grazyna Orłowska-Kowalik, Andrzej Ksiazek
Some anthropometric measurements are usually used to estimate the nutritional status of dialysis patients. The aim of our study was the comparison of some anthropometric measurements in patients adequately (from the clinical point of view) treated with peritoneal dialysis (PD) and hemodialysis (HD). The study was performed on 40 chronic dialysis (both: PD and HD), non-diabetic patients, without any inflammatory process. The patients were divided into two groups, 20 patients in each: I peritoneal dialysis patients (PD-pts), II--hemodialysis patients (HD-pts). In each patient body mass index (BMI), total body water (TBW), lean body mass (LBM), fat body mass (FBM), upper limb musculature (ULM), mid arm circumference in tension and in rest MAC-t and MAC-r), triceps skinfold thickness (TSF) and dialysis index (Kt/V) were determined. The obtained values were analyzed statistically and compared between the groups. In peritoneal dialysis the patients' higher values of BMI, FBM, MAC and TSF (p < 0.01), as well as higher LBM and ULM (p < 0.05) than those in hemodialysis patients were observed. TBW was not statistically different in the PD and HD patients (p > 0.05). Mean Kt/V values observed were as follows: 2.16 +/- 0.48 in PD patients vs 1.05 +/- 0.35 in the HD patients; (p < 0.01). We conclude that adequately treated, from the clinical point of view the PD patients had better anthropometric indicators of nutritional status than the adequately treated HD patients.
{"title":"Comparison between some anthropometric measurements in adequately treated peritoneal dialysis and hemodialysis patients.","authors":"Agnieszka Magdalena Grzebalska, Maria Majdan, Ewa Bober, Grazyna Orłowska-Kowalik, Andrzej Ksiazek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Some anthropometric measurements are usually used to estimate the nutritional status of dialysis patients. The aim of our study was the comparison of some anthropometric measurements in patients adequately (from the clinical point of view) treated with peritoneal dialysis (PD) and hemodialysis (HD). The study was performed on 40 chronic dialysis (both: PD and HD), non-diabetic patients, without any inflammatory process. The patients were divided into two groups, 20 patients in each: I peritoneal dialysis patients (PD-pts), II--hemodialysis patients (HD-pts). In each patient body mass index (BMI), total body water (TBW), lean body mass (LBM), fat body mass (FBM), upper limb musculature (ULM), mid arm circumference in tension and in rest MAC-t and MAC-r), triceps skinfold thickness (TSF) and dialysis index (Kt/V) were determined. The obtained values were analyzed statistically and compared between the groups. In peritoneal dialysis the patients' higher values of BMI, FBM, MAC and TSF (p < 0.01), as well as higher LBM and ULM (p < 0.05) than those in hemodialysis patients were observed. TBW was not statistically different in the PD and HD patients (p > 0.05). Mean Kt/V values observed were as follows: 2.16 +/- 0.48 in PD patients vs 1.05 +/- 0.35 in the HD patients; (p < 0.01). We conclude that adequately treated, from the clinical point of view the PD patients had better anthropometric indicators of nutritional status than the adequately treated HD patients.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 1","pages":"20-3"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24995977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the paper was to evaluate the knowledge of rules of healthy nourishment as well as the recommended components of a daily diet among students of junior and senior high schools. The lifestyle of the teenagers was analyzed in two groups--junior high school students and senior high school students. On the basis of the BMI the state of nutrition of the population was evaluated. The subjects were questioned about the most frequent health problems, and the connection between body weight and the development of diseases in the future. The research was carried out by means of an anonymous survey among 200 students of junior high schools and 200 students of senior high schools. The data underwent statistical analysis. The knowledge of healthy eating habits proved insufficient and their realization poor, especially among junior high school students. The factors that influence the lifestyle of the teenagers included the family and the media. In girls the lack of acceptance of their own appearance was recorded, which resulted in the desire to lower body weight and to apply slimming diets.
{"title":"Knowledge of rules of healthy lifestyle and their realization among students of junior and senior high schools.","authors":"Ewa Chemperek, Dorota Zołnierczuk-Kieliszek, Małgorzata Płowaś","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the paper was to evaluate the knowledge of rules of healthy nourishment as well as the recommended components of a daily diet among students of junior and senior high schools. The lifestyle of the teenagers was analyzed in two groups--junior high school students and senior high school students. On the basis of the BMI the state of nutrition of the population was evaluated. The subjects were questioned about the most frequent health problems, and the connection between body weight and the development of diseases in the future. The research was carried out by means of an anonymous survey among 200 students of junior high schools and 200 students of senior high schools. The data underwent statistical analysis. The knowledge of healthy eating habits proved insufficient and their realization poor, especially among junior high school students. The factors that influence the lifestyle of the teenagers included the family and the media. In girls the lack of acceptance of their own appearance was recorded, which resulted in the desire to lower body weight and to apply slimming diets.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 1","pages":"24-31"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24995978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Success in endodontic treatment with application of non-hardening calcium hydroxide preparations to periapical pathosis has been described. The clinical procedures consisted in elaboration of root canals and temporary filling with Biopulp preparation. Control clinical and radiological investigations were carried out after 3 and 6 months. In spite of occurrence of initial periapical pathosis, the method of treatment with calcium hydroxide preparations permitted to achive positive results of healing of periapical pathosis thus eliminating the necessity of surgical operation.
{"title":"Selected cases of periapical changes treated with calcium hydroxide preparations.","authors":"Anna Scibak, Ewa Kuczyńska, Teresa Bachanek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Success in endodontic treatment with application of non-hardening calcium hydroxide preparations to periapical pathosis has been described. The clinical procedures consisted in elaboration of root canals and temporary filling with Biopulp preparation. Control clinical and radiological investigations were carried out after 3 and 6 months. In spite of occurrence of initial periapical pathosis, the method of treatment with calcium hydroxide preparations permitted to achive positive results of healing of periapical pathosis thus eliminating the necessity of surgical operation.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 1","pages":"397-401"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24995986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Pilarczyk, Jacek Jaworski, Andrzej Fidor, Marcin Nastaj, Jacek Porebiak, Zbigniew Stelmasiak
We present the patient with pendular nystagmus. The condition is secondary to long-term work as an underground coal miner. The issue is worth describing because of its rare presence in contemporary either neurological or ophthalmological literature.
{"title":"Diagnosis: miner's nystagmus.","authors":"Maria Pilarczyk, Jacek Jaworski, Andrzej Fidor, Marcin Nastaj, Jacek Porebiak, Zbigniew Stelmasiak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present the patient with pendular nystagmus. The condition is secondary to long-term work as an underground coal miner. The issue is worth describing because of its rare presence in contemporary either neurological or ophthalmological literature.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 2","pages":"207-8"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24995989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Janusz Sykut, Paweł Mieszkowski, Magdalena Bakalczuk, Janusz Kleinrok
In this work a description of prosthetic treatment of the edentulous patient with cleft palate was showed. Although positive results of surgical treatment diminish the number of these patients, more than once a dentist has to treat effectively patients in their fifties, sixties and seventies whose cleft palate was not treated with modern methods. Authors describe prosthetic solution which enables removing part of acryl from prosthesis and making air chambers. Diminishing of obturator prosthesis mass increases stabilization and retention and contributes to easier adaptation of prosthetic restoration.
{"title":"Prosthetic rehabilitation of edentulous patients with cleft palate.","authors":"Janusz Sykut, Paweł Mieszkowski, Magdalena Bakalczuk, Janusz Kleinrok","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this work a description of prosthetic treatment of the edentulous patient with cleft palate was showed. Although positive results of surgical treatment diminish the number of these patients, more than once a dentist has to treat effectively patients in their fifties, sixties and seventies whose cleft palate was not treated with modern methods. Authors describe prosthetic solution which enables removing part of acryl from prosthesis and making air chambers. Diminishing of obturator prosthesis mass increases stabilization and retention and contributes to easier adaptation of prosthetic restoration.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 2","pages":"209-12"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24995990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Students in some determined situations, for example before an examination in a new environment are exposed to many somatic and psychic reactions. Stress can be determined (or shown) as a syndrome of somatic and psychic changes which can be the consequences of difficult situations to overcome. Some symptoms of stress are: tachycardia, excessive perspiration, dyspeptic symptoms, sleep and menstruation disorders. Different types of reactions and their frequency due to stress among the students of Medical University of Lublin were examined by means of a questionnaire.
{"title":"The origin of stress, its causes, symptoms and frequency of appearance among the students of Medical University of Lublin.","authors":"Dalia Chrzanowska, Leszek Wdowiak, Iwona Bojar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Students in some determined situations, for example before an examination in a new environment are exposed to many somatic and psychic reactions. Stress can be determined (or shown) as a syndrome of somatic and psychic changes which can be the consequences of difficult situations to overcome. Some symptoms of stress are: tachycardia, excessive perspiration, dyspeptic symptoms, sleep and menstruation disorders. Different types of reactions and their frequency due to stress among the students of Medical University of Lublin were examined by means of a questionnaire.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 1","pages":"438-43"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24996465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the study was analysing of the diagnostic value of different imaging modalities in evaluation patients with bowel obstruction. The material comprises a group of 47 patients with diagnosed acute abdomen. Erect radiography, and radiographs in supine and left lateral patients' positions, US and CT examination were performed in those patients. CT examination was performed in 5 mm--and 10-mm thick axial sections before and after administering the contrast agent. In 6 patients small barium enema was performed. In 5 cases water-soluble contrast was administered orally. In 6 cases on plane radiographs the presence of high small bowel obstruction was found. In 3 cases the level of small bowel obstruction was in the distal ileum. In 12 patients the obstruction of large bowel was seen on plain radiographs. In 3 patients intussusception of sigmoid bowel was found. The mesenteric ischemia was found to be a reason of bowel obstruction in 5 cases. On CT section soft tissue mass with irregular contrast enhancement was found, reflecting ischemic intestinal loops. In 2 patients the gall stone small bowel obstruction was found. In one of them the presence of gas in the biliary tree was seen on CT images. The determining of the level of the obstruction is facilitated on plain radiographs, erect and in supine and left lateral patients' position. In small bowel obstruction, normal or equivocal initial radiographs may result in a delayed diagnosis. As the bowel diameter cannot be assessed the plain radiographic diagnosis is difficult or impossible. If there is persistent diagnostic difficulty, follow-up plain radiographs taken a few hours later will often resolve the problem and, if not, a barium study or CT may be performed. Orally administering of water-soluble contrast agent, diluted barium, barium enema are also helpful in differentiating the character and etiology of obstruction.
{"title":"The diagnostic value of different imaging modalities in evaluation of bowel obstruction.","authors":"Marek Pasławski, Jacek Gwizdak, Janusz Złomaniec","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the study was analysing of the diagnostic value of different imaging modalities in evaluation patients with bowel obstruction. The material comprises a group of 47 patients with diagnosed acute abdomen. Erect radiography, and radiographs in supine and left lateral patients' positions, US and CT examination were performed in those patients. CT examination was performed in 5 mm--and 10-mm thick axial sections before and after administering the contrast agent. In 6 patients small barium enema was performed. In 5 cases water-soluble contrast was administered orally. In 6 cases on plane radiographs the presence of high small bowel obstruction was found. In 3 cases the level of small bowel obstruction was in the distal ileum. In 12 patients the obstruction of large bowel was seen on plain radiographs. In 3 patients intussusception of sigmoid bowel was found. The mesenteric ischemia was found to be a reason of bowel obstruction in 5 cases. On CT section soft tissue mass with irregular contrast enhancement was found, reflecting ischemic intestinal loops. In 2 patients the gall stone small bowel obstruction was found. In one of them the presence of gas in the biliary tree was seen on CT images. The determining of the level of the obstruction is facilitated on plain radiographs, erect and in supine and left lateral patients' position. In small bowel obstruction, normal or equivocal initial radiographs may result in a delayed diagnosis. As the bowel diameter cannot be assessed the plain radiographic diagnosis is difficult or impossible. If there is persistent diagnostic difficulty, follow-up plain radiographs taken a few hours later will often resolve the problem and, if not, a barium study or CT may be performed. Orally administering of water-soluble contrast agent, diluted barium, barium enema are also helpful in differentiating the character and etiology of obstruction.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 2","pages":"268-74"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24996471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Lis-Sochocka, Mirosław Lańcut, Krystyna Czerny
The proximal convoluted tubules of the kidney of white Wistar rats were examined. The animals were given Cladribine (2-CdA) subcutaneously at dosages of 0.07 mg/kg b.m./24 h for 7 days and 0.1 mg/kg b.m./24 h for 6 days in three courses with 5 weeks' break between each. The animals were decapitated 24 hours after the last dose of the drug and 4 weeks after the last dose. The kidney samples were taken for ultrastructural examination. Giving Cladribine at the dose of 0.1 mg/kg b.m./24 h for 7 successive days does not lead to instant changes in the ultrastructure of the proximal convoluted tubules. Changes noticed 4 weeks after Cladribine administration are the following: decrease in amount of mitochondria, the presence of numerous vacuoles, changes in the structure of the brush border, presence of numerous glycogen granules, and the presence of a diluted cytoplasm around the nucleus. Giving 2-CdA at the dose of 0.07 mg/kg b.m./24 h for 6 days in three courses leads to similar changes in proximal convoluted tubules with more extensive damages of the brush border. These were no more intensive after 4 weeks' break in Cladribine administration.
{"title":"Ultrastructure of kidney renal proximal convoluted tubules of experimental animals after Cladribine (2-CdA) administration.","authors":"Marta Lis-Sochocka, Mirosław Lańcut, Krystyna Czerny","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The proximal convoluted tubules of the kidney of white Wistar rats were examined. The animals were given Cladribine (2-CdA) subcutaneously at dosages of 0.07 mg/kg b.m./24 h for 7 days and 0.1 mg/kg b.m./24 h for 6 days in three courses with 5 weeks' break between each. The animals were decapitated 24 hours after the last dose of the drug and 4 weeks after the last dose. The kidney samples were taken for ultrastructural examination. Giving Cladribine at the dose of 0.1 mg/kg b.m./24 h for 7 successive days does not lead to instant changes in the ultrastructure of the proximal convoluted tubules. Changes noticed 4 weeks after Cladribine administration are the following: decrease in amount of mitochondria, the presence of numerous vacuoles, changes in the structure of the brush border, presence of numerous glycogen granules, and the presence of a diluted cytoplasm around the nucleus. Giving 2-CdA at the dose of 0.07 mg/kg b.m./24 h for 6 days in three courses leads to similar changes in proximal convoluted tubules with more extensive damages of the brush border. These were no more intensive after 4 weeks' break in Cladribine administration.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 1","pages":"157-62"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25286412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}