Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina最新文献

The purpose of this study was to evaluate maternal serum angiotensin I, angiotensin II and aldosterone level, plasma renin activity, angiotensin converting enzyme activity in pregnancies complicated by preeclampsia with and without intrauterine growth retardation. The study was carried out on 26 patients with singleton pregnancy complicated by preeclampsia (group P) and 12 preeeclamptic patients with preeclampsia complicated by intrauterine growth retardation (group PI). The control group consisted of 18 healthy normotensive patients with singleton uncomplicated pregnancies, without any renal, heart and vascular diseases and normal laboratory tests (group K). Decreased angiotensin I level and decreased plasma renin activity in maternal blood in preeclamptic patients were found to be lower in comparison with the control group. Decreased plasma angiotensin II levels in maternal blood in preeclamptic patients were found to be lower in comparison with the control group. Maternal aldosterone levels were lower in both study groups in comparison with the healthy controls. Elevated serum angiotensin-converting enzyme activity in preeclamptic patients without IUGR was found to be higher in comparison with the healthy controls and with the preeclamptic patients with IUGR. Our results and other reports point out the significant role of RAAS activity in the pregnancy complicated by preeclampsia.

Cardiac arrest is a very important problem, because of its aetiology and consequences. It is defined as a sudden cessation of the pumping action of the heart, leading to death, which can be prevented if proper measures are taken immediately. A very important issue is the quality of life of patients after cardiac arrest and the presence of neurological and mental disorders. The aim of this study is review of the literature relative to this subject.

On the grounds of literature and own clinical experience, pathological changes in epilepitic patients have been described. Dental management procedures in these patients have also been presented. The unquestionable importance of prophylaxis, which may markedly minimize the impact of epilepsy on the incidence of mouth diseases, has been emphasised. It has also been stated that epileptic patients should receive specialised and integrated dental treatment.

The aim of this paper was to establish the frequency and intensity of smoking by the patients and hospital staff and to define the attitudes of the polled persons towards smoking tobacco on the premises of the hospital and their opinions about the limitations in force. The examination in the form of a distributed questionnaire, comprised 101 patients and 127 staff members of Henryk Klimontowicz Specialist Hospital in Gorlice (province of Małopolska /Little Poland/). Both mobile and bed-ridden patients participated in the study. The personnel was represented by physicians, nurses, ward attendants, psychologists, secretaries, Medical University students doing their apprenticeships on the premises of the hospital, employees of technical and administrative departments. The study was carried out by means of a diagnostic sounding with the use of a distributed questionnaire technique in the period from September 2002 to July 2003. The questionnaire contained 38 questions, including closed, open, half-open and multiple-choice questions. In our poll we used the Fagerstrom test, which determined the type of addiction to smoking tobacco (physical or psychological), and which was completed by tobacco-smokers. The statistical analysis was carried out by means of the Chi2 test for independence, assuming the significance level of 0.05. The obtained results were analyzed according to the sex of the polled persons and their functions in the premises of the hospital (patient, staff member). The results of the obtained analysis show that 13.9% of the polled patients of the Specialist Hospital in Gorlice smoked cigarettes every day. The percentage of everyday smokers among the staff of this hospital was significantly higher and equalled 18.1%. Half of the polled persons were exposed to passive smoking on the premises of the hospital, the staff more than the patients. The patients supported the restrictions concerning smoking on the premises of the hospital to a greater extent than the personnel. Most of the smokers claimed that they were trying to cut down on smoking on the premises of the hospital. Despite these declarations, tobacco-smokers smoked cigarettes in the area of the hospital anyway, and one fifth of the smokers smoked also outside the places designed for that purpose.

Galvano-forming is modern technique used to make esthetic permanent prosthetic restorations displacing lost-wax method. The replacement of wax by metal produces marginal tightness of 70 microm. The technology satisfies esthetic demands, ensures beneficial and long-tern effects. Galvanic products are characterized by high biocompatibility, excellent marginal tightness (tightness of ca 18 microm), pulp protection, chance to apply traditional neutral zinc-phosphate cement and high esthetic quality.

Unlabelled: The purpose of the work was the analysis of the number and structure of new neoplasm and morbidity in children living in rural areas of the Lublin Region of Poland.

Methods: the study included the population of children aged 0-17 in the years 1988-2000. The tumours were divided according to the International Classification of Childhood Cancers. The analysis determined the incidence of all tumours and individual types and the rates of percentage structure and incidence. These parameters were calculated for the whole population according to sex and age.

Results: 430 cases of childhood cancers were reported. Boys were 53.7%. The most frequent was leukemia (24.4%), neoplasm of CNS (19.5%) and lymphomas (16%). The mean morbidity rate was 100,8 per million (among boys--105.6, girls--95.8).

Conclusions: I. The patient's place of residence is one of the factors affecting the structure of cancers. 2. Higher percentage of lymphomas and CNS tumours and lower percentage of leucaemias and tumours of the sympathetic nervous system and bones was observed in the Lublin Region compared to the values determined for the whole country. 3. The population examined showed lower malignant tumour incidence than that in the whole country as well as increased lymphoma incidence.

The purpose of the study was histological evaluation of the liver of a pregnant rat, which 4 weeks before planned pregnancy was administered adriamycin intraperitoneally in a dose of 5 mg/kg of body weight. Focal damage of hepatocytes ("naked nuclei" which were the evidence of cell damage) were observed in histological preparations. Significant steatosis and vessel damage were visible as well. Around the central vein and in portocholangial space numerous ductules spuriae appear.

High resolution computed tomography is a diagnostic modality of choice in imaging of interstitial lung diseases. HRCT enables visualization of the pathological findings invisible on plain radiographs and their evaluation at the level of the pulmonary lobule. The aim of the study was evaluation of typical HRCT findings in patients with bronchiolitis, and assessment of their usefulness in differential diagnosis. Tree in bud is a typical sign seen on HRCT sections in patients with bronchiolitis, resulting from filling the small centrilobular bronchioles with puss, mucus, granulomas or inflammatory cells. Material filling the bronchioles causes their obstruction resulting in the presence of air-trapping, visible on expiratory sections. Thickening of the bronchiolar walls and dilatation of the small bronchioles is also very often seen. Ground glass opacities and small nodules are also seen in some patients with bronchiolitis.

Unlabelled: Dopamine (DA) is biogenic amine that in the central (CNS) and peripheral nervous system plays an important role as a neurotransmitter and neuromediator. Dopamine neurones in CNS are responsible for regulating motor and emotional processes, higher psychological activities and hormone secretion. Acute pancreatitis (AP) is a general disease condition caused by pancreas extrasecretory cell damage which leads to self-digestion. One of its results is encephalopathy in consequence of shock symptoms, intravascular clotting, brain tissue ischaemia etc. The study has aimed at analysis of changes in the level of DA in rats' cerebral cortex in the course of experimental AP. The experiment was carried out on 102 rats. They were divided into three groups: Z - healthy (12), K - control (30), OP - experimental (60). The AP was induced in OP group according to Heinkel and Aho method. In K group the needle was only inserted into the common bile-pancreatic duct to analyse the effects of mechanical damage. The activity of pancreatic enzymes was determined to estimate the intensity of pancreatitis. The dopamine level was measured in rats << brain samples and to do so, the Brodie method modified by Chang was used. The statistical analysis was carried out.

Conclusions: The greatest changes of DA level during experimental AP were noticed during the first 24 hours of experiment and they were in statistically significant way correlated with the level of lipase and amylase in blood serum. Peak DA concentration was detected between 6th and 12th hour of experiment.

The usage of psychoactive substances can be related to a vast percentage of teenage population. Smoking cigarettes, drinking alcohol or taking drugs during the stage of growth and development can lead to detrimental health effect and, frequently, to serious addictions. The aim of this paper was the evaluation of the spreading frequency of mentioned habits among the high school students. The precise analysis of causes of these pathological phenomena, as well as elaboration and actual usage of broad-scale educational and prophylactic programs seem indispensable.